|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
40-446 |
4.53e-150 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 432.17 E-value: 4.53e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASA-TLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:cd17366 6 LGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAqLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:cd17366 86 CIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRsrleetpvfreleeqaqrreqsaaaaalplgrllvryaRPLLLLGGLVVALNV 278
Cdd:cd17366 166 EAQMLDWGWRIPFLIAAPLGLVGLYLR--------------------------------------RPLLICIGLVLVFNV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGA 358
Cdd:cd17366 208 TNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 359 -FVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGL 437
Cdd:cd17366 288 iFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGL 367
|
....*....
gi 736048739 438 VALSAVIET 446
Cdd:cd17366 368 VAVLFLTET 376
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
40-455 |
1.15e-118 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 355.94 E-value: 1.15e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASATLFA-LGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:PRK10642 23 LGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAaLATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:PRK10642 103 CIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIVG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRE-LEEQAQR-REQSAAAAALPLGRLLVRYARPLLLLGGLVVAL 276
Cdd:PRK10642 183 EANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhVDKLEQGdREGLQDGPKVSFKEIATKHWRSLLTCIGLVIAT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 277 NVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVL 356
Cdd:PRK10642 263 NVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAIPAFILINSNVI 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 357 GA-FVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVSTsLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAV 435
Cdd:PRK10642 343 GLiFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISV-LVAGLTPTLAAWLVESTQNLMMPAYYLMVVAVI 421
|
410 420
....*....|....*....|
gi 736048739 436 GLVALSAVIETRGCSLRGDA 455
Cdd:PRK10642 422 GLITGVTMKETANRPLKGAT 441
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
40-440 |
2.38e-109 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 329.10 E-value: 2.38e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFP--GSTASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGAT 117
Cdd:cd17369 9 VGTAIEWYDFFIYGTAAALVFNKLFFpaVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIAT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 118 LLVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLL 197
Cdd:cd17369 89 FLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 198 GDTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELEEQAQRReqsaaaaALPLGRLLVRYARPLLLLGGLVVALN 277
Cdd:cd17369 169 SDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVV-------RAPLVEVLRRHWRALLLAIGLRLAEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 278 VVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALM--THGV 355
Cdd:cd17369 242 VLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLdtGSTW 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 356 LGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAV 435
Cdd:cd17369 322 LIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVI 401
|
....*
gi 736048739 436 GLVAL 440
Cdd:cd17369 402 SLVAA 406
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
41-437 |
1.59e-108 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 326.54 E-value: 1.59e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 41 GNATEWFDYGIYAYGLAYISAALFP--GSTASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPpsGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFReleeqaqRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNV 278
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFE-------KAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHG---- 354
Cdd:TIGR00883 234 TFYLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSgsft 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 355 -VLGAFVGFAVLGLLYVpqlATISAMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAAC 433
Cdd:TIGR00883 314 lFFFLVLGMALIGGMYT---GPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALA 390
|
....
gi 736048739 434 AVGL 437
Cdd:TIGR00883 391 LIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
40-447 |
2.72e-90 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 280.34 E-value: 2.72e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGS-TASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:cd17367 6 VGNLVEWYDWYVYAAFALYFAPQFFPSGdPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:cd17367 86 VIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFrelEEQAQRREQSAAaaalpLGRLLVRYARPLLLLGGLVVALNV 278
Cdd:cd17367 166 EDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESF---EAIAESNEASAG-----TLRELRRHPRELLLVVGLTAGGTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHG--VL 356
Cdd:cd17367 238 AFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTdsPY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 357 GAFVGFAVlGLLYVPQLATISAMFPA-MFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLiGKTGNTMIPAYYMMAACAV 435
Cdd:cd17367 318 TAFALVLV-GLVFLSGYTSINAVVKAeLFPTHVRALGVGLPYALAVAIFGGTAPYVALWL-KSIGHEWVFFWYVAGLIAI 395
|
410
....*....|..
gi 736048739 436 GLVALSAVIETR 447
Cdd:cd17367 396 SLVVYLRMPETR 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
40-446 |
6.43e-78 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 248.44 E-value: 6.43e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFP-GSTASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:cd17368 6 SGNALEFFDFGVYGFFAVYIGRLFFPsGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:cd17368 86 LIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELEEQAQRREqsaaaaalpLGRLLVRYARPLLLLGGLVVALNV 278
Cdd:cd17368 166 AEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE---------LFALLANNRRIILLGMLLVAGSTV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMT-HGVLG 357
Cdd:cd17368 237 TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTaAPSFG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 358 AF-VGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVG 436
Cdd:cd17368 317 RLlLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLG 396
|
410
....*....|
gi 736048739 437 LVALSAVIET 446
Cdd:cd17368 397 LLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-440 |
3.97e-61 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 202.83 E-value: 3.97e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASATLFalgTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:cd17316 6 LGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGL---LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLGD 199
Cdd:cd17316 83 IGLLPTPIL--------LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 TamhaWGWRLPFLVAAPLGLIGFYLRSRLeetpvfreleeqaqrreqsaaaaalplgrllvryarplLLLGGLVVALNVV 279
Cdd:cd17316 155 D----WGWRILFLIGALPALLALLLRRRT--------------------------------------LLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 280 NYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAF 359
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 360 VGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNdWLIGKTGNTMIPAYYMMAACAVGLVA 439
Cdd:cd17316 273 LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIA-LLLASTGGTGVPALILALLAIVALIV 351
|
.
gi 736048739 440 L 440
Cdd:cd17316 352 A 352
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
41-440 |
3.27e-58 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 197.65 E-value: 3.27e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 41 GNATEWFDYGIYAYGLAYI-SAALFPG-STASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATL 118
Cdd:PRK09952 30 GAVVDWYDFLLYGITAALVfNREFFPQvSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIATA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 119 LVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLG 198
Cdd:PRK09952 110 LIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTT 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 199 DTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFREleeqaQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNV 278
Cdd:PRK09952 190 DEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQ-----QQHEQAAAKKRIPVIEALLRHPGAFLKIIALRLCELL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWI-SLVGLfVAAVPMFALMTHGVLG 357
Cdd:PRK09952 265 TMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITgALIGT-LSAFPFFMALEAQSIF 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 358 AFVGFAVLgllyvpqLATIS---------AMFPAMFPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIG-KTGNTMIPAY 427
Cdd:PRK09952 344 WIVFFSIM-------LANIAhdmvvcvqqPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTyFGGSWHSVAI 416
|
410
....*....|....
gi 736048739 428 YMMAACAVG-LVAL 440
Cdd:PRK09952 417 YLLAGCLISaMTAL 430
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
41-448 |
1.32e-56 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 193.62 E-value: 1.32e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 41 GNATEWFDYGIYAYGLAYISAALFPGSTASATLF-ALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMlTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSF--------LEFATLAGFSLGallml 191
Cdd:PRK15075 103 IAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWqsasqqvaVVFAALLGYLLN----- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 192 gfaLLLGDTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFreleeqAQRREQSAAAAALplgRLLVRYARPLLLLGG 271
Cdd:PRK15075 178 ---QWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF------LARKHRPSMREIF---RSLAANWRIVLAGML 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 272 LVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKT-MWWISLVGLFVA------- 343
Cdd:PRK15075 246 MVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPvLIAFTVLAILTAypalswl 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 344 -AVPMFALMthgvLGAFVGFAVLGLLYvpQLATISAMFPAMfPTHVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNT 422
Cdd:PRK15075 326 vAAPSFARM----LAVELWLSFLYGSY--NGAMVVALTEVM-PAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDK 398
|
410 420
....*....|....*....|....*.
gi 736048739 423 MIPAYYMMAACAVGLVALSAVIETRG 448
Cdd:PRK15075 399 AAPGYWLSFAAVCGLIATLVLYRRRG 424
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
41-411 |
5.83e-53 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 183.86 E-value: 5.83e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 41 GNATEWFDYGIYAYGLAYISAALFP-GSTASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:PRK10406 30 GNLVEWFDFYVYSFCSLYFAHIFFPsGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLGD 199
Cdd:PRK10406 110 IACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTLED 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 TAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETpvfreleEQAQRREQSAAAAAlplgRLLVRYARPLLLLGGLVVALNVV 279
Cdd:PRK10406 190 AELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSL----KGLWRNRRAFIMVLGFTAAGSLC 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 280 NYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKT--MWWISLVGLFvaAVPMFALMTH--GV 355
Cdd:PRK10406 259 FYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTsmLCFGSLAALF--TVPILSALQNvsSP 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736048739 356 LGAFvGFAVLGLLYVPQLATISAMFPA-MFPTHVRYAGMAIAYNVSTSLFGGTAPIV 411
Cdd:PRK10406 337 YAAF-GLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANALFGGSAEYV 392
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
79-447 |
4.30e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 123.45 E-value: 4.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 79 FAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATF 158
Cdd:COG2223 46 FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 159 IAEYAPDARRGLCGSFlefaTLAGFSLGALLMLGFALLlgdtAMHAWGWRLPFLVAAPLGLI-GFYLRSRLEETPVFREL 237
Cdd:COG2223 118 VSKWFPPDRRGLALGL----AAGGGNLGAAVAAFLAPL----LIAAFGWRNAFLILGILLLVvAVLAWLFLRDPPAGAAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 238 EEQAQRREQSAAAAALPLGRLLVRYArpllllgglvvALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLL 317
Cdd:COG2223 190 AAKASLRDQLEALRDPRFWLLSLLYF-----------GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 318 PFAGWLSDRVGRKTMWWISLVGLFVAAVpMFALMTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAY 397
Cdd:COG2223 259 PLGGWLSDRIGGRRVLLIVFALMALGLL-LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 736048739 398 NVStSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVALSAVIETR 447
Cdd:COG2223 338 AAG-GLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
40-451 |
8.55e-31 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 123.54 E-value: 8.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPG------STASATLFALGTFAISFLIRPLGGLFWGPLGDRLGRKRVLAltvltM 113
Cdd:pfam00083 7 LGGFLFGYDTGVIGAFLTLIDFFKNFGlsksvsSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL-----I 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 114 SGATLLVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGallmlGF 193
Cdd:pfam00083 82 ANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA-----YI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 194 ALLLGDTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVF------------------------RELEEQAQRREQSAA 249
Cdd:pfam00083 157 FGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdRELDEIKDSLEAGQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 250 AAALPLGRLLVR--YARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSEnlSLLIPLLGMLAMMVLLPFAGWLSDRV 327
Cdd:pfam00083 237 AEKASWKELFSTktRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 328 GRKTMWWISLVGLFVAAVPM---FALMTHGVLGAFVGFAVLGLLYV----PQLATISAMFPA-MFPTHVRYAGMAIAYNV 399
Cdd:pfam00083 315 GRRPLLLLGAAGMAICFVILgivALLGVSKSDWAGIVAIVFIALFIaffaMGWGPVPWVIVSeLFPLSVRSKAMALATAA 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 736048739 400 STsLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVALSAVIETRGCSL 451
Cdd:pfam00083 395 NW-LANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTL 445
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
40-399 |
6.32e-29 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 117.40 E-value: 6.32e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISA--ALFPGSTASATLFALGTFAIsflirplGGLFWGPLGDRLGRKRVLALTVLTMSGAT 117
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAefGLDEAEAGLLGTVTLAGGAI-------GGILGGILADRFGRVRVLVITILLFAVFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 118 LLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEfatlAGFSLGALLMLGFALLL 197
Cdd:cd17371 79 LLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAALL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 198 GDTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFreleEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALN 277
Cdd:cd17371 147 FPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQW----QAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 278 VVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLG 357
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLI 302
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 736048739 358 AFVGFAvLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNV 399
Cdd:cd17371 303 LILGFP-LGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNV 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
31-399 |
1.38e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 1.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 31 PRVAIAAAALGNATEWFDYGIYAYGLAYISAALfpGSTASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTV 110
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGLVVTAYLLGAAL---GAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 111 LTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLM 190
Cdd:COG2814 83 LLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 191 LGfalllgdtAMHAWGWRLPFLVAAPLGLIGFYLRSRLeetpvFRELEEQAQRREQSAAAAALPLGRLLVRYArpllllg 270
Cdd:COG2814 155 GL--------LADLFGWRWVFLVNAVLALLALLLLLRL-----LPESRPAARARLRGSLRELLRRPRLLLLLL------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 271 gLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFal 350
Cdd:COG2814 215 -LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA-- 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 736048739 351 MTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNV 399
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-444 |
5.66e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.12 E-value: 5.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASATLFALGtfaisFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAF-----FLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGfalllgd 199
Cdd:COG2271 92 FGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 tAMHAWGWRLPFLVAAPLGLIGFYLRSRLeetpvfreleeqaqrreqsaaaaalplgrllvryarplllLGGLVVALNVV 279
Cdd:COG2271 157 -LLAAFGWRAAFLILGLPGLLLALLRFWL----------------------------------------LALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 280 NYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAF 359
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAI 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 360 VGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAyNVSTSLFGGTAPIVNDWLIGKTGntMIPAYYMMAACAVGLVA 439
Cdd:COG2271 276 ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATG--YQAAFLLLAALALLAAL 352
|
....*
gi 736048739 440 LSAVI 444
Cdd:COG2271 353 LALLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
40-324 |
9.16e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 103.74 E-value: 9.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASATLFALGTFAisfliRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:COG0477 21 LGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLG-----RAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTyasagwlaPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGfalllgd 199
Cdd:COG0477 96 CGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 tAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELEEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVV 279
Cdd:COG0477 161 -LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 736048739 280 NYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLS 324
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
79-444 |
7.75e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.49 E-value: 7.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 79 FAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATF 158
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 159 IAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFAlllgdtamHAWGWRLPFLVAAPLGLIGFYLRSRLEEtpvfrelE 238
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA--------DALGYRAPFLVCAALALLALVLALLLLP-------E 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 239 EQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLP 318
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 319 FAGWLSDRVGRKtmwWISLVGLFVAAVPMFAL-MTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIaY 397
Cdd:cd17325 254 PAGKLSDRIGRK---PLILIGLLLSAVALLLLpLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-F 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 736048739 398 NVSTSLFGGTAPIVNDWLIGKTGntmipaYYMMAACAVGLVALSAVI 444
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFG------FATPFLAAAALLLLAAVL 370
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
40-411 |
8.59e-21 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 94.76 E-value: 8.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALFPGSTASATLFAlgtfaISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:PRK03893 27 LGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLIS-----AAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLefatLAGFSLGALLMLGFALLLGD 199
Cdd:PRK03893 102 CGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVAAQVYSLVVP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 tamhAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELEE-------------QAQRREQSAAAAALPLGRLLVRYARPL 266
Cdd:PRK03893 170 ----VWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAgkapvrtmvdilyRGEHRIINILLTLAAAAALWFCFAGNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 267 LLLGGLVVALNVVNYVLLAYM--------------------------------PTYMHKELGVSENLSLLIPLLGMLAMM 314
Cdd:PRK03893 246 QNAAIVAVLGLLCAAIFISFMvqssgkrwptgvmlmvvvlfaflyswpiqallPTYLKTDLGYDPHTVANVLFFSGFGAA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 315 VLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMthgvlGAFVGFaVLGLLYVPQLAT--ISAMFPAM----FPTHV 388
Cdd:PRK03893 326 VGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIG-----GANVWV-LGLLLFFQQMLGqgISGLLPKLiggyFDTEQ 399
|
410 420
....*....|....*....|...
gi 736048739 389 RYAGMAIAYNVStSLFGGTAPIV 411
Cdd:PRK03893 400 RAAGLGFTYNVG-ALGGALAPIL 421
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
79-409 |
4.01e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 4.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 79 FAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATF 158
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 159 IAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFalllgdtaMHAWGWRLPFLVAAPLGLIGFYLRsrleetpVFRELE 238
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--------ASLFGWRAAFLILAILSLLAAVLL-------LLPRPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 239 EQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMhKELGVSENLSLLIPLLGMLAMMVLLP 318
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 319 FAGWLSDRVGRKTMWWISLVGLFVAAVP-MFALMTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIaY 397
Cdd:pfam07690 254 LLGRLSDRLGRRRRLLLALLLLILAALGlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-Y 332
|
330
....*....|..
gi 736048739 398 NVSTSLFGGTAP 409
Cdd:pfam07690 333 NTAGSLGGALGP 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-416 |
4.22e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.79 E-value: 4.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 47 FDYGIYAYGLAYISAALfpgSTASATLFALGTFAISFLIrpLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTY 126
Cdd:TIGR00895 31 YDLAAMGFAAPAISAEW---GLDPVQLGFLFSAGLIGMA--FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 127 ASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLefatLAGFSLGALLMLGFALLlgdtAMHAWG 206
Cdd:TIGR00895 106 TQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVGGFLAGW----LIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 207 WRLPFLVA--APLGLIGF----------YLRSRLEETPVFR--ELEEQAQRREQSAAA---AALPLGRLLV------RYA 263
Cdd:TIGR00895 170 WRSLFYVGgiAPLLLLLLlmrflpesidFLVSKRPETVRRIvnAIAPQMQAEAQSALPeqkSTQGTKRSVFkalfqgKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 264 RPLLLLGGLVVALNVVNYVLLAYMPTYMhKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLV-GLFV 342
Cdd:TIGR00895 250 RITVLLWLLYFMLLVGVYFLTNWLPKLM-VELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLgAVFA 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 343 AAVPMFALMTHGVL--GAFVGFAVLGLLYVpqLATISAMFpamFPTHVRYAGMAIAYNVStSLFGGTAPIVNDWLI 416
Cdd:TIGR00895 329 VLVGSTLFSPTLLLllGAIAGFFVNGGQSG--LYALMALF---YPTAIRATGVGWAIGIG-RLGAIIGPILAGYLL 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
47-440 |
1.89e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.85 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 47 FDYGIYAYGLAYISAALFPGSTASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTY 126
Cdd:cd06174 8 TGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYAL---LQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 127 ASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFalllgdTAMHAWG 206
Cdd:cd06174 85 WL--------LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL------ASSLGFG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 207 WRLPFLVAAPLGLIGFYLRSRleetpVFRELEEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAY 286
Cdd:cd06174 151 WRAVFLIAAALALLAAILLLL-----VVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 287 MPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRV-GRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAVL 365
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 366 GLLyvpqLATISAMFPAMFPTHVRYAGMAIA-YNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVAL 440
Cdd:cd06174 306 GLG----GLLPLSFALIAELFPPEIRGTAFGlLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
68-440 |
3.30e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.84 E-value: 3.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 68 TASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFS 147
Cdd:cd17319 36 SPTQYGLIASAFFLGYAL---FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 148 TGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGfalllgdtAMHAWGWRLPFLVAAPLGLIgfylrsr 227
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW--------LLLLFGWRWAFIIEGLLGLL------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 228 leetpvfreleeqaqrreqsaaaaalpLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPL 307
Cdd:cd17319 170 ---------------------------LAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 308 LGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPM-FALMTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPT 386
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLlLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 736048739 387 HVRYAGMAIaYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVAL 440
Cdd:cd17319 303 EAAATAGGL-INSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
88-369 |
1.23e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasagwlapAALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 R----GLCGSFLEFATLAGFSLGALLMLgfalllgdtamhAWGWRLPFLVAAPLGLIGFY-LRSRLEETPVFRELEEQAQ 242
Cdd:cd17324 121 RgraiGLVFSGLTLGLVLGRPLGGLLGQ------------LLGWRAAFLAIAVLALLAALlLWRLLPSLPPKKPGSLGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 243 RREqsaaAAALPLGRLLVRYArpllllggLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGW 322
Cdd:cd17324 189 SSL----LLLLRNPRLRLAYL--------ITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 736048739 323 LSDRVGRKTMwwISLVGLFVAAVPMFALMTHGVLGAFVGFAVLGLLY 369
Cdd:cd17324 257 LADRGGRRAL--LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF 301
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-420 |
2.14e-12 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 68.80 E-value: 2.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 40 LGNATEWFDYGIYAYGLAYISAALfpGSTASATLFaLGTFAisFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLL 119
Cdd:PRK12307 25 LGYVFDGFDFMLIFYIMYLIKADL--GLTDMEGAF-LATAA--FIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 120 VGVlptyASAGWLapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLefatLAGFSLGALLMLGFALLLGD 199
Cdd:PRK12307 100 SGL----ASGVIM----LTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNIIAAYFMPSFAE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 200 tamhAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELEEQAQRREQSAAAAALPLGRLLVrYARPLLLLGGLVVALNV- 278
Cdd:PRK12307 168 ----AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGL-FNRAQFPLTLCVFIVLFs 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 ---VNYVLLAYMPTYMHKE---LGVSENLsLLIPLLGMLAMMVllpFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMT 352
Cdd:PRK12307 243 ifgANWPIFGLLPTYLAGEgfdTGVVSNL-MTAAAFGTVLGNI---VWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQ 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736048739 353 HGVLgaFVGFAVLGLLYVPqlATISAMFPAM----FPTHVRYAGMAIAYNVSTSlfGGT-APIVNDWLIGKTG 420
Cdd:PRK12307 319 DNYL--LLGACLFGLMATN--VGVGGLVPKFlydyFPLEVRGLGTGLIYNLAAT--SGTfNSMAATWLGITMG 385
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
88-394 |
2.16e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 64.91 E-value: 2.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTyasagwlaPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGSFlefaTLAGFSLGALLMLGFALLLGDTamhaWGWRLPFLVAAPLGLIGF-YLRSRLeetpvfreleeqaqrreq 246
Cdd:cd17365 121 RSLAVTL----MFCGYPLGAALGGFLAAALIPA----FGWRSVFLLGGVPPLILLpLLRGTL------------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 247 sAAAAALPLGRLLVryarpllllgglvvalnvvnYVLLAYMPTYMhKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDR 326
Cdd:cd17365 175 -LLWVTFFMGLLLV--------------------YLLNSWLPKLM-VEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 327 VGRK--TMWWISLVGLFVAAvpmFALMTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMA 394
Cdd:cd17365 233 FGPKrvLALFFALGAVSLAL---LGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVG 299
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
88-396 |
3.10e-11 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 64.90 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI--------FIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGSFLEFATLAGFSLGALLMLGFALLLGDTAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPvfreleeqaqrreqs 247
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESP--------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 248 aaaaalplgRLLVRYARPLLLLGGLVVAL------NVVNYvllaYMPTyMHKELGVSENLSLLIPLLGMLAMMVLLPFAG 321
Cdd:cd17359 188 ---------RWLVSKGKPILIIGIGLAIFqqfvgiNVIFY----YGPE-IFQNAGFSENAALLQTIGIGVVNVIFTIIAI 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 322 WLSDRVGRKTMWWISLVG----LFVAAVPMFALMTHGVLGAFVGFAVLGLLYVPQL---ATISAMFPAMFPTHVRYAGMA 394
Cdd:cd17359 254 LLVDKVGRKPLLLIGSIGmaisLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMswgPVTWVLLSEIFPNRIRGLAMG 333
|
..
gi 736048739 395 IA 396
Cdd:cd17359 334 IA 335
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
51-420 |
3.53e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.92 E-value: 3.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 51 IYAYGLAYISAALFPGSTASATLFALGTFaISFLIRPLGGLFWGPLGDRLGRKR-VLALTVLTMSGATLLVGVLPTYASA 129
Cdd:COG2211 29 LSAYLLYFYTDVLGLSAALVGLILLVARL-WDAITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 130 G--WLAPAALIVLRMVQGFSTGGeyggAATFIAEYAPDAR-RGLCGSFLEFATLAGFSLGALLMLGFALLLGDTAmhAWG 206
Cdd:COG2211 108 GklIYALVTYLLLGLAYTLVNIP----YSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 207 WRLPFLVAAPLGLIGFYLrsrleetpVFRELEEQAQRREQsaaaaALPLGRLL--VRYARPLLLLGGLVVALNVVNYVLL 284
Cdd:COG2211 182 YRLTALIFAVLGLLAFLL--------TFFGTKERPVPEEE-----KVSLKESLkaLLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 285 AYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAV 364
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAAL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736048739 365 LGLLYVPQLATISAMFPAMFP-----THVRYAGMAIA-YNVSTSLFGGTAPIVNDWLIGKTG 420
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVDydewkTGRRREGLYFGiFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-444 |
9.41e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.00 E-value: 9.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 74 FALGTFAI-SFLIRPLGGLfwgpLGDRLGRKRVLALTVLTMSGATLLVGVLPTyasagwlaPAALIVLRMVQGFSTGGEY 152
Cdd:cd17489 35 LVVGLFTLaALLARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 153 GGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFalllgdtaMHAWGWRLPFLVAAPLGLIGFYLRSRLEETP 232
Cdd:cd17489 103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL--------YQHLGFAVLFIVAAVLALLALLLVFLVKDPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 233 vfreleeqaQRREQSAAAAALPLGRLLVRYARPLLLLGGLVValnVVNYVLLAYMPTYMhKELGVSeNLSLLIPLLGmLA 312
Cdd:cd17489 175 ---------PVAAEEAEAGTRAFRRLVEKKVLPPALILFLAS---IAYGAISTFLPLYA-AERGIS-NAGLFFTVYA-IA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 313 MMVLLPFAGWLSDRVGRKTMwwiSLVGLFVAAVPMFAL-MTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYA 391
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTV---IIPGLLLLALGLLLLsFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 736048739 392 GMAIaYNVSTSLFGGTAPIVNDWLIGKTGntmipaYYMMAACAVGLVALSAVI 444
Cdd:cd17489 317 ANGT-FFIFFDLGIGLGGLLLGLVAELFG------YRAMFLLAAVVVLLALVL 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
91-444 |
1.34e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 62.58 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 91 LFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTyasagwlaPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARR-- 168
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 169 --GLCGSFLEFATLAGFSLGALLmlgfalllgdtaMHAWGWRLPFLVAAPLGLIGFYLrsrleetpvfreleeqaqrreq 246
Cdd:cd17321 121 alGLWGAVVGIGAALGPLLGGLL------------LELFGWRWIFLINVPIGLVALLL---------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 247 saaaaalplgrllvryARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDR 326
Cdd:cd17321 167 ----------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 327 VGRKTmwwISLVGLFVAAVPMFALMTHGVLGAFVGFAV--------LGLLYVPQLATISAMFP--------AMFPThVRY 390
Cdd:cd17321 231 FGPRL---VLVAGLLLTAVGLLLLALLGADSSVWLLLPglvllglgLGLFATPLTNAALSSVPkekagaasGILNT-ARQ 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 736048739 391 AGMAIAYNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMA-----ACAVGLVALSAVI 444
Cdd:cd17321 307 LGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGfhlafLVAAALALLAALL 365
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
80-246 |
2.79e-10 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 62.05 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 80 AISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASAGWLapAALIVLRMVQGFSTGGEYGGAATFI 159
Cdd:TIGR00887 63 GSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVM--ATLCFWRFWLGVGIGGDYPLSAIIT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 160 AEYAPDARRG--------------LCGSFLEFATLAGFSLGALLMLGFALLLGDTAMHA-WGWRLPFLVAAPLGLIGFYL 224
Cdd:TIGR00887 141 SEFATKKWRGammaavfamqgfgiLAGAIVALIVLAGFKHSLEAAADEASCTGSCVPAVdYMWRILIGFGAVPALLALYF 220
|
170 180
....*....|....*....|....*..
gi 736048739 225 RSRLEETP-----VFRELEEQAQRREQ 246
Cdd:TIGR00887 221 RLTIPETPrytadVAKDVEQAASDMSA 247
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
88-396 |
6.98e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 60.28 E-value: 6.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasagwlapAALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNV--------WVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGS----FLEFATLAGFSLGALLMLgfalllgdtaMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFreleeqaqr 243
Cdd:cd17315 121 RGALGTlnqlMITFGILLAYLLGLALSL----------SPPGWWRLMFALAAVPALLQLLLMFFLPESRAL--------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 244 reqsAAAAALPLGRLLVryarpllllgglvvALNVVNYvllaYMPTYMhKELGvSENLSLLIPLLGMLAMMVLLPFAGWL 323
Cdd:cd17315 182 ----LVGVGLQLLQQLT--------------GINAVMY----YAPTIF-KSAG-GGTASILASIIVGVVNLLATLVAIRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 324 SDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGF-AVLG-LLYV--------PQLATISamfPAMFPTHVRYAGM 393
Cdd:cd17315 238 VDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWlALLGiLLYIaafamgagPVPWLLL---SEIFPLRIRGKGM 314
|
...
gi 736048739 394 AIA 396
Cdd:cd17315 315 AIA 317
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
88-440 |
7.52e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 7.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSgatlLVGVLPTYASAGWlapaALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYG----IGGVAGLFLDSLY----ALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 R----GLCGSFLEFATLAGFSLGAllmlgfalllgdtAMHAWGWRLPFLV-AAPLGLIGFYLRSrLEETPVfrelEEQAQ 242
Cdd:cd17473 122 RakmlGLQSAAMSLGGVVFLLLGG-------------ALAEIGWRAPFLVyLLALPVLILVLLF-LPEPAR----KSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 243 RREQSAAAAALPLGRLLVRYArpllllggLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGW 322
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYF--------LAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 323 LSDRVGRKTMWWISLVgLFVAAVPMFALmTHGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIaynVSTS 402
Cdd:cd17473 256 LKRRLGKRRLLAIGFA-LMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI---VTSA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 736048739 403 LFGG--TAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVAL 440
Cdd:cd17473 331 FFLGqfLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
65-228 |
1.22e-09 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 59.98 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 65 PGSTASATLFALGtfAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASAGwlAPAALIVLRMVQ 144
Cdd:cd17364 33 KGSLPSGVSGLVN--AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLG--VMGWLIFFRFLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 145 GFSTGGEYGGAATFIAEYAPDARRG----LCGSFLEFATLAGFSLGALLMLGFALLLGDTAMHA--WGWRLPFLVAAPLG 218
Cdd:cd17364 109 GIGIGGDYPLSATIMSEYANKKRRGaliaAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHHadLVWRIVLGLGAIPA 188
|
170
....*....|
gi 736048739 219 LIGFYLRSRL 228
Cdd:cd17364 189 LSVLYFRKHL 198
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
89-400 |
1.61e-09 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 59.66 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 89 GGLFWGPLGDRLGRKRVLAltvltMSGATLLVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARR 168
Cdd:TIGR00879 87 GALFAGWLSDRFGRKKSLL-----IIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALR 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 169 GLCGSFLEFATLAGFSLGALLMLGFALLLGDTamhawGWRLPFLVAAPLGLIGFYLRSRLEETPVF---RELEEQAQR-- 243
Cdd:TIGR00879 162 GALTSLYQLAITFGILVAYGFGSGKVSLNNTL-----GWRIPLGLQLIPAGLLFLGLFFLPESPRWlvgKGRVEEARKsl 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 244 ---REQSAAAAALPLGRLLVRYARPLLLLGGLVVALNV------VNYVLLA-----------------YMPTYMHKELGV 297
Cdd:TIGR00879 237 arlRGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSLfsstrrIRRRLFLgvvlqwfqqftginaimYYSPTIFENAGV 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 298 SENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVG----LFVAAVPMFALMTHGVLGAFVGFAVLGLLYV--- 370
Cdd:TIGR00879 317 STDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGmaicLFVLGILGASFVTGSSKSSGNVAIVFILLFIaff 396
|
330 340 350
....*....|....*....|....*....|..
gi 736048739 371 -PQLATISAMFPA-MFPTHVRYAGMAIAYNVS 400
Cdd:TIGR00879 397 aMGWGPVPWVIVSeIFPLSLRPKGISIAVAAN 428
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-440 |
1.82e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.13 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 51 IYAYGLAYISAALfpGSTASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasag 130
Cdd:cd17320 17 MYLPALPAIARDL--GASASAVQLTLSAYLLGFAL---GQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI---- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 131 wlapAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFalllgdtaMHAWGWRLP 210
Cdd:cd17320 88 ----EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL--------LLFFGWRAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 211 FLVAAPLGLIGFYLrsrleetpVFRELEEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTY 290
Cdd:cd17320 156 FVFLALLGLLLLLL--------VLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 291 MHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVpMFALMTHGVLGAFVGFAVLGLLYV 370
Cdd:cd17320 228 YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAAL-VLLLAALLGGLSLWPLVAPLFLIF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736048739 371 PQLATI--SAMFPAMFP-THVRYAGMAIAYNVSTSLFGGTAPIVNDWLIGktgnTMIPAYYMMAACAVGLVAL 440
Cdd:cd17320 307 FGFGLIfpNATSLALEPfPHVAGTASALLGFLQFLIGALAGALVGLLPNG----TALPMGLLILVLGLLALLL 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
68-444 |
2.69e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 68 TASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasagwlapAALIVLRMVQGFS 147
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLL---ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 148 TGGEYGGAATFIAEYAPDARR---GLCGSFLEFATLAGFSLGALLMLGFALLlgdtamhawGWRLPFLVAA--PLGLIGF 222
Cdd:COG0738 110 LGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLILLGLSL---------SWHLPYLILAvlLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 223 YLRSRLEETpvfrELEEQAQRREQSAAAAALPLGRLLVryarplllLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLS 302
Cdd:COG0738 181 FLRSKLPEI----EEEEEEAAGSAASLKSLLKNPRLLL--------GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 303 LLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVpmFALMTHGVLGAFVGFAVLGLLyvpqlatISAMFPA 382
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL--LALLAPGPWLALIGLALVGLG-------LSLMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736048739 383 MFP----THVRYAGMAIAYNVSTSLFGGT-APIVNDWLIGKTGntMIPAYYMMAACAVGLVALSAVI 444
Cdd:COG0738 320 IFSlaldGLGKRTAAAVSAVLIMGIVGGAiGPPLIGFLADAFG--LRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
78-351 |
3.51e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.40 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 78 TFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAAT 157
Cdd:cd17328 42 VFIISYMV---LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 158 FIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFalllgdtAMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPvfREL 237
Cdd:cd17328 111 IIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV-------AQATGGWRWAFRVTGVLGVLLAILLLLFVREP--PRG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 238 EEQAQRREQSAAAAALPLGRLLVRyARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGV----SENLSLLIPLLGMLAM 313
Cdd:cd17328 182 AAEGGVMAKSTATSFLADLKALAK-NPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVgdlsSADVGLIFGAITCIAG 260
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 736048739 314 MVLLPFAGWLSDRVGRKTMWW---ISLVGLFVAAVPMFALM 351
Cdd:cd17328 261 VLGVLLGGILADRLRRKTPRAdplVCAVGLLAAAPFLFLAL 301
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
88-223 |
6.55e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 58.10 E-value: 6.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTV--------FLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 736048739 168 RGLCGSFLEFAtlagFSLGALLMLGFALLLGDtamhawgWR-LPFLVAAPLGLIGFY 223
Cdd:TIGR00898 214 RAIVGTLIQVF----FSLGLVLLPLVAYFIPD-------WRwLQLAVSLPTFLFFLL 259
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-440 |
4.08e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 4.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 50 GIYAYGLAYISAALFPGSTASATLFALGTFAISFLIrplggLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasa 129
Cdd:cd17474 16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLM-----PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 130 gwlapAALIVLRMVQGFSTGGEYGGAATFIAEYAPDARR----GLCGSFLEFATLAGFSLGAllmlgfalllgdtAMHAW 205
Cdd:cd17474 88 -----ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGG-------------LLAAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 206 GWRLPFLVAAPLGLIGFYLRSRLEETPvfreleeqaQRREQSAAAAALPLGRLLVRYaRPLLLLGGLVVALNVVNYVLLA 285
Cdd:cd17474 150 SWRYPFFLLAALIPVAFLAILFLLPEP---------KEKAKSSSATKLRDLKKALRG-RGLLTFLVSAFLYFFLYFAFLT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 286 YMPTYMHKELGVSE-NLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAV 364
Cdd:cd17474 220 YLPFLLELLYGISPiIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736048739 365 LGL-LYVPQLATISAMFpamFPTHVRYAGMAiAYNVSTSLFGGTAPIVNDWLIGKTGNTMIpaYYMMAACAVGLVAL 440
Cdd:cd17474 300 LGLgLNLPLLTTLVTEL---APEEERGTASS-LYNFVRFLGQAVGPLLFGLLLEIFGLSAP--FLVGAAIALAAAVL 370
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
50-452 |
4.96e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 54.67 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 50 GIYAYGLAYISAALFPGSTASA---TLFALGTFAISFLIRP------LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLV 120
Cdd:cd17362 7 LLFGYDIGATSGALLSITSPALsgtDWYNLSSLQSGLVVSGsllgalLGSLVAGALIDRLGRRKELILAALLYLVGSLVT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 121 GVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLgdt 200
Cdd:cd17362 87 GLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVV--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 201 amhaWGWRLPFLVAAPLGLIGFYLRSRLEETPvfreleeqaqrREQSAAAAALPLGRLLVRYARpllllggLVVALNVvn 280
Cdd:cd17362 156 ----GGWRYMYGLAAPPALLLGIGMWFLPPSP-----------RWQGNYRKPLIIGLGLVLFQQ-------ITGQPSV-- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 281 yvlLAYMPTYMhKELGVS--ENLSLLIPLLGMLAMMVLLPfAGWLSDRVGRKTMWWISLVGLFVAAVPM--FALMTHGVL 356
Cdd:cd17362 212 ---LYYAATIF-KSAGFSaaSDATLVSVGLGVFKLLMTIV-AVLLVDKLGRRPLLLGGVSGMVVSLFLLaaYNLFVQMGP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 357 GAFVGFAVLGLL-----YVPQLATIS-AMFPAMFPTHVRYAGMAIAYNV---STSLFGGTAPIVNDwLIGKTGNTMIpaY 427
Cdd:cd17362 287 AGLAWLSLVALLlyvgaYQISFGPISwLMVSEIFPLRVRGRAIALAVLVnfgSNALVSLAFLPLQE-LIGLPGTFLG--F 363
|
410 420
....*....|....*....|....*
gi 736048739 428 YMMAACAVGLVALSaVIETRGCSLR 452
Cdd:cd17362 364 GVIGVLALLFIYFT-VPETKGLSLE 387
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
68-440 |
1.92e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 68 TASATLFALgTFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLptyASAGWLAPAALIVLRMVQGFS 147
Cdd:cd06173 30 TGSALLVGL-VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALL---ALLGSLSLWLLLVLAFLLGIA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 148 TGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGfalllgdtAMHAWGWRLPFLVAAPLGLIGFYLRSR 227
Cdd:cd06173 106 SAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGL--------LVALLGPGGAFAINALSFLLSALLLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 228 LeetpvfRELEEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLI-- 305
Cdd:cd06173 178 I------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLla 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 306 -PLLGMLAMMVLLpfaGWLSDRVGRKtmwWISLVGLFVAAVPMFAL-MTHGVLGAFVGFAVLGLLYVPQLATISAMFPAM 383
Cdd:cd06173 252 aFGVGALLGALLL---GRLSKRRRRG---RLLLIGALLLGLALLVLgLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736048739 384 FPTHVRYAGMAIAYNVSTSLFGGTAPIVndWLIGKTGNTMIPAYYMMAACAVGLVAL 440
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLA--GLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
88-441 |
2.58e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.63 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasagwlapAALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY--------PVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGSFLEFATLAGFSLGALLMLGfalllgdTAMHAwGWRLPFLVAAPLGLIGFYLrsrleetpVFRELEEQAQRREQS 247
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPP-------LALHY-GWRAAFVVAGLVSILAAVL--------FWLFYREPPAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 248 AAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRV 327
Cdd:cd17475 182 ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 328 G----RKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAVLGLL----YVPQLATISAMFPAmfpthvRYAGMAIAYNV 399
Cdd:cd17475 262 FggrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFaigwNGLYLTLVAESAGP------EQAGTALGLAN 335
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 736048739 400 STSLFG-GTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVALS 441
Cdd:cd17475 336 TINFIGiAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
88-369 |
7.62e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 7.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVlptyasagWLAPAALIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL--------TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGSFLEFATLAGFSLGALLMLGFALLLGdtamhawgwrLPFLVAAPLGLIGFylrsrleeTPVFRELEEQAQRREQS 247
Cdd:cd17477 118 RGRVLGLYSTVLGLGFALGPLLLALVGTAGA----------LPFLIAAVLLLLAL--------VPLLLTRRAAPEIEEAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 248 AAAaalplgrlLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHkELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRV 327
Cdd:cd17477 180 SIS--------LRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 736048739 328 GR-KTMWWISLVGLFVAAVPMFALMTHGVLGAFVGF--AVLGLLY 369
Cdd:cd17477 251 DRrRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPLY 295
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
88-439 |
7.97e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 7.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFSTGGEYGGAATFIAEYAPDaR 167
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGNVLLPGLIKRWFPD-R 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 168 RGLCGSFLEFATLAGFSLGALLMLGfalllgdtAMHAWGWRLPFLVAAPLGLIGFYLRsrleeTPVFREleeqaQRREQS 247
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVP--------LAAALGWRGALAVWALLALLALLLW-----LPLLRR-----RPAAAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 248 AAAAALPLGRLLVRyaRPLLLLGGLVVALNVVNYVLLAYMPTYMHkELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRV 327
Cdd:COG2807 201 AAPAAASLRSLWRS--PLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 328 GRKTMWWISLVGLFVAAVPMFALMTHGvlGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYA---GMAIAynvSTSLF 404
Cdd:COG2807 278 GDRRPLLLLLGLLGLAGLLGLLLAPGS--LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAalsGMAQS---VGYLL 352
|
330 340 350
....*....|....*....|....*....|....*
gi 736048739 405 GGTAPIVNDWLIGKTGNTMIPAYYMMAACAVGLVA 439
Cdd:COG2807 353 AALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
61-368 |
9.09e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 9.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 61 AALFPGSTASATLFALGTFAISFLIRPLGGLFwgplGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVL 140
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYL----ADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 141 RMVQGFSTGGEYGGAATFIAEYAPdARRGLCGSFLEFATLAGFSLGALLMLGfalllgdtAMHAWGWRLPFLVAAPLGLI 220
Cdd:cd17478 91 VALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAA--------LVALFGGLGLLILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 221 GFYLRSRLEETPvfreleeqaqRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSEN 300
Cdd:cd17478 162 VALLLLRLRPLK----------KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736048739 301 LSLLIPLLgMLAMMVLLPFAGWLSDRVGRKTMWWISLVGlfvAAVPMFALMTHGVLGAFVGFAVLGLL 368
Cdd:cd17478 232 AGLLLSLF-LFAGAIGTLIGGPLSDRFGRRRVIIASLLL---AAPFLLLFLLTPGIWSYILLVLAGFL 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
280-420 |
1.24e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 280 NYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVpmFALMTHGVLGAF 359
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL--LLLFASSLWLLL 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736048739 360 VGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIaYNVSTSLFGGTAPIVNDWLIGKTG 420
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
56-326 |
3.98e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 56 LAYISAALFPGSTASATLFALGTFAISFLIRPLGGlfwGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapA 135
Cdd:cd17380 20 IAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLG---GYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSL------P 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 136 ALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLefatLAGFSLGALLMLGFALLLgdtaMHAWGWRLPFLVAA 215
Cdd:cd17380 91 LLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIV----TAGSYLGTLLGGLIGPLL----LEYYGWPSVFYFFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 216 PLGLIGFYlrsrleetpvfreleeqaqrreqsaaaaalplgrLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKEL 295
Cdd:cd17380 163 LLGLLWAL----------------------------------VWLIYLPPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL 208
|
250 260 270
....*....|....*....|....*....|.
gi 736048739 296 gVSENLSLLIPLLGMLAMMVLLPFAGWLSDR 326
Cdd:cd17380 209 -VPLAKGWVFNVVPWLVMFPSSNVAGWLADH 238
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
74-362 |
4.08e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 48.79 E-value: 4.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 74 FALGTFAisflirplGGLFWGPLGDRLGRKR-VLALTVLTMSGATLLVGVLPtyasaGWlapAALIVLRMVQGFSTGGEY 152
Cdd:cd17356 54 VNLGSFF--------GALISSFLSDRIGRKKsIQIGCVIYIIGAIIQVAAIG-----KW---YQLIVGRIIAGLGVGFAS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 153 GGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGallmlgfalLLGDTAMHAWG----WRLPF---LVAAPLGLIGFYLr 225
Cdd:cd17356 118 VLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVA---------YCINYGTHKLDgsaqWRIPLglqIVWGLLLLIGMFF- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 226 srLEETPvfreleeqaqrreqsaaaaalplgrllvRYARPLLLLGGLVVALNV--VNYVLlaYMPTYMHKELGVSENLSL 303
Cdd:cd17356 188 --LPESP----------------------------RWLYRTILGIMLQLFQQLtgINYFF--YYGTTIFQSTGLTGSSPL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 304 LIPLLGMLAMMVLLPFAGWLSDRVGRKTmwwislvGLFVAAVPMFALM-THGVLGAFVGF 362
Cdd:cd17356 236 LTSIILYIVNFVSTIPGLFFVDKFGRRT-------CLLIGAAGMSICLfIYAAVGVRYLI 288
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
74-351 |
5.30e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 48.41 E-value: 5.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 74 FALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALtvltmSGATLLVGVLPTYASAGWLAPAALIVLRMVQGFSTGGEYG 153
Cdd:cd17357 53 LIVSIFFIGGAI---GSFISAFLANRFGRKNGLLI-----SNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 154 GAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLGDTamhawgWRLPFLVAAPLGLI------------G 221
Cdd:cd17357 125 FVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETL------WPYLLFFPGIPALLqlaalpffpespK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 222 FYLRSRLEET--------------PVFRELEEQAQRREQSAAAAALPLGRLL--VRYARPLLLLGGLVVALNVVNYVLLA 285
Cdd:cd17357 199 FLLISKGDEEeaekslkflrgiedDVDQELEEIKKESEQMGDQKQVSLMQLLrdPSLRLPLLLVLVVSASQQFSGINAIF 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 286 YMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALM 351
Cdd:cd17357 279 FYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFL 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
96-365 |
6.29e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 6.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 96 LGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDARRG----LC 171
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGaamgLV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 172 GSFLEFATLAGFSLGALLMLgfalllgdtamhAWGWRLPFLVAAPLGLIGFY----LRSRLEETPVFReleeqaqrreqs 247
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTD------------NLSWRWIFYINLPIGILALLlaplLDLRLFKDRNFT------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 248 AAAAALPLGRLLVryarpllllgglvvalnvvnYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRV 327
Cdd:cd17503 182 LGLLLSFLLGLGL--------------------FGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF 241
|
250 260 270
....*....|....*....|....*....|....*...
gi 736048739 328 GRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAVL 365
Cdd:cd17503 242 GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFI 279
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
88-411 |
2.88e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWG------P---LGDRLGRKRVLALTVLTMSGATLLVgvlPTYASAGWlapAALIVLRMVQGFSTGGEYGGAATF 158
Cdd:cd17318 62 LSSFFYGyiltqiPggyLAEKYGAKRVLGYSILITALLTLLT---PLAARGGY---GALIVLRILQGLAQGVTFPAMHAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 159 IAEYAPDARRGLCGSFlefaTLAGFSLGALLMLGFALLLGDTamhaWGWRLPFLVAAPLGLIGFYlrsrleetpvfrele 238
Cdd:cd17318 136 WAKWAPPLERSRLTSI----AYSGSQFGTVIAMPLSGFLCES----LGWPSIFYIFGGLGLLWCL--------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 239 eqaqrreqsaaaaalplgrLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLP 318
Cdd:cd17318 193 -------------------LWFFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSI 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 319 FAGWLSDRVGRKtmWWISL---------VGLFVAAVPMFALMTHGV-LGAFVGFAVLGllyvpqLATISAMFPAMFPTHV 388
Cdd:cd17318 254 VGGYLADWLRSR--GILSTttvrklftsIGFLGPGVFLIALGYLGSnATLAVVFLTLS------VGLSGACYSGFLVNHL 325
|
330 340
....*....|....*....|....*....
gi 736048739 389 ----RYAG--MAIaynvsTSLFGGTAPIV 411
Cdd:cd17318 326 dlapNYAGtlMGI-----TNTAATIAGII 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
78-406 |
6.73e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 6.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 78 TFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPtyaSAGWlapaaLIVLRMVQGFSTgGEYGGAAT 157
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVT---NVWQ-----LLILRLLQGVFS-GYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 158 FIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLgdtamhawGWRLPFLVAAPLGLIGFYLRS---RLEETPVF 234
Cdd:cd17391 112 LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF--------GIRNVFFITGGLLFLAFLLTLffvKEDFKPVE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 235 RELEEQAQRREQSAAAAALPLGRLLVRYarpllllgGLVVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGmLAMM 314
Cdd:cd17391 184 KKKMVSTKEVWNSVPNPSLLISLFVTTF--------IIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATG-VSSL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 315 VLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAF---VGFAVLGLlyvpqLATISAMFPAMFPThvRYA 391
Cdd:cd17391 255 LSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILrflLGLATGGL-----LPAINSLLAKITPK--EVA 327
|
330
....*....|....*
gi 736048739 392 GMAIAYNVSTSLFGG 406
Cdd:cd17391 328 GRIFGYNQSFQYLGN 342
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
54-451 |
7.18e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 44.79 E-value: 7.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 54 YGLAYISAALFPGSTASATL-----FALGTFAISFLIRPLGGlfwGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAs 128
Cdd:cd17435 15 YELGIISGALLQLRTLLALScheqeMVVSSLLIGALLASLTG---GVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYT- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 129 agwlapaALIVLRMVQGFSTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALLLGdtamhawGWR 208
Cdd:cd17435 91 -------VLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 209 LPFLVAAPLGLIGFYLRSRLEETPVFRELEEQAQRReqsaaaaaLPLGRLLVRYARPLLLLGglvvalnvvnyvLLAYMP 288
Cdd:cd17435 157 YMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRAR--------LLIGLTLVFFVQITGQPN------------ILFYAS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 289 TYMhKELGVSEN--LSLLIPLLGMLAMMVLLPfAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLGAFVGFAVLG 366
Cdd:cd17435 217 TVL-KSVGFQSNeaASLASTGVGVVKVVSTIP-AIFLVDKVGSKTFLCIGSSVMAVSLVTMGLWLSLASLLVYVAAFSIG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 367 LLYVPQLatisaMFPAMFPTHVRYAGMAI--AYNVSTSLFGGTAPIVNDWLIGKTgnTMIPAYYMMAACAVGLVALsAVI 444
Cdd:cd17435 295 LGPMPWL-----VLSEIFPGGIRGRAMALtsSMNWGINLLISLTFLTVTELIGLP--WVCFIYTAMSLASLVFVIM-FVP 366
|
....*..
gi 736048739 445 ETRGCSL 451
Cdd:cd17435 367 ETKGCSL 373
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
88-186 |
9.10e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 9.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 88 LGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATFIAEYAPDAR 167
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL--------FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90
....*....|....*....
gi 736048739 168 RGLCGSFLEFAtlagFSLG 186
Cdd:cd17317 112 RSFVGILFGLF----WALG 126
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
281-395 |
1.03e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.41 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 281 YVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVG-RKTMWWISLVGLFVAAVPMF---ALMTHGVL 356
Cdd:cd17337 225 FGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGwRRTVRWFGGVGCAISTLLFYyvpQLFGHNYW 304
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 736048739 357 GAFVGFAVLGLL---YVPqlatISAMFPAMFPTHvRYAGMAI 395
Cdd:cd17337 305 AALIAAILFGIGlagFVP----LSALMPSLAPEH-KGAAMSI 341
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
91-444 |
2.86e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.95 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 91 LFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYAsagwlapaALIVLRMVQGFStGGEYGGAATFIAEYAPDARRGL 170
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGRALQGIG-GAVFPLAFALVREEFPPERVPV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 171 CGSFLefatLAGFSLGALLMLGFALLLGDTamhaWGWRLPFLVAAPLGLIGFYLrsrleeTPVFReLEEQAQRREQSAAA 250
Cdd:cd17504 120 AQGIL----SATFGIGAGIGLPLGGWIVQH----LGWRWIFWTAAPVAVLLAAL------VPLID-LRLLRRRNVLLANI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 251 AALPLGrllvryarpllllgglvVALNVVNYVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGrk 330
Cdd:cd17504 185 TALLAG-----------------FGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG-- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 331 tMWWISLVGLFVAAVPMFALMTHG------VLGAFVGFAVLGLLYVPQLATISAMFPAMFP-------THVRYAGMAIAY 397
Cdd:cd17504 246 -PRRVLLIGLVISAVGLLLLALLHsslwalVVALLLIGIGLGLAFASLPNIVVESVPPDRTgiatgmnTVLRTIGSAIGP 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 736048739 398 NVSTSLFGGTAPIVNDWLIGKTGNTMIpAYYMMAACAVGLVALSAVI 444
Cdd:cd17504 325 AIAGAILTTYTVSITSGGVPTEGAYVL-AFLIGAALALAALLLSLLI 370
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
289-440 |
3.08e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.00 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 289 TYMHKELGVSENlSLLIPLLGMLAMMVLLPFAGWLSDRVGRKtmwWISLVGLFVAAVPMFALMT-HGVLGAFVGFAVLGL 367
Cdd:cd06179 22 PFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRR---WFFIGGNLLGVVGSIVAGTaKSVNMLIGGQALIGI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736048739 368 LYVPQLATISAMfPAMFPTHVRYAGMAIAyNVSTSLFGGTAPIVNDWLIGKTGNTMIPAYYMMAA-CAVGLVAL 440
Cdd:cd06179 98 GAGTQGLGAAVA-SELVPNKYRGLVQGVV-NLVASPGSALGPLIAGALVEANAAGWRWIFYINAIfNALALILL 169
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
72-147 |
4.32e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 42.21 E-value: 4.32e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 72 TLFALGtFAIsflirplGGLFWGPLGDRLGRKRVLALTVltmsgatlLVGVLPTYASAGWLAPAALIVLRMVQGFS 147
Cdd:PRK11102 33 SAYILG-FAI-------GQLFYGPMADSFGRKPVILGGT--------LVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
64-383 |
4.51e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 42.42 E-value: 4.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 64 FPGSTASATLFALGTFAISFLIRPLGGLFwgplGDRLGRKRVLALTVLTMSgatLLVGVLPTYASAGWlapAALIVLRMV 143
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYL----AGKYVFKWSIGIGMFLSS---VISIVIPWAAGGGI---ALVVFCRVI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 144 QGFSTGGEYGGAATFIAEYAPDARRGLCGSflefATLAGFSLGALLMLGFALLLGDTAMhawGWRLPF----LVAAPLGL 219
Cdd:TIGR00894 141 QGLAQGSVSPATHKIIVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCESWG---GWPMIFyvfgIVGCAWSL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 220 IGFYL----------RSRLEETPVFRELEEQAQRREQSAAAAALPLgrllvryARPLLLLGGLVVALNVVNYVLLAYMPT 289
Cdd:TIGR00894 214 LWFVFpaddpsihpcISKFEKKYINSSLQGQKGSTRQSLPIKAIPK-------SLPVWAIWFAIFGHFWLYTILPTYLPT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 290 YMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSD----------RVGRKTMWWIS--LVGLFVAAVP---------MF 348
Cdd:TIGR00894 287 FISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADflkssktlslTAARKIFNGIGglGPGIFAYALPylsaafyltII 366
|
330 340 350
....*....|....*....|....*....|....*..
gi 736048739 349 ALMTHGVLGAFV--GFAVLGLLYVPQLATISAMFPAM 383
Cdd:TIGR00894 367 ILTLANAVSSGPlaGVLINSLDLAPRFLGFIKGITGL 403
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
87-186 |
5.17e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.18 E-value: 5.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 87 PLGGLFWGPLGDRLGRKRvlaltvltmsgaTLLVGVLPtyASAGWLAPAA------LIVLRMVQGFSTGGEYGGAATFIA 160
Cdd:cd17358 55 LIGALLSGKLADRIGRKR------------TLLISAIP--CILGWLLIAFakdvwmLYLGRFLAGFGGGAASVVVPVYIA 120
|
90 100 110
....*....|....*....|....*....|
gi 736048739 161 EYAPDARRGLCGSFLE----FATLAGFSLG 186
Cdd:cd17358 121 EIAPKNVRGALGSLNQllvnIGILLGYVLG 150
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
51-146 |
6.69e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 6.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 51 IYAYGLAYISAALfpGSTASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALtvltmsgaTLLVGVLPTYASAG 130
Cdd:TIGR00710 23 MYLPAFPEIAADL--STPASIVQMTLTLYLLGFAA---GQLLWGPLSDRYGRRPVLLL--------GLFIFALSSLGLAL 89
|
90
....*....|....*.
gi 736048739 131 WLAPAALIVLRMVQGF 146
Cdd:TIGR00710 90 SNNIETLLVLRFVQAF 105
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
280-442 |
8.49e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 8.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 280 NYVLLAYMPTYMHkELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVPMFALMTHGVLgaF 359
Cdd:COG2814 26 IGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL--L 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 360 VGFAVLGLLYVPQLATISAMFPAMFPTHVRyaGMAIAYNVSTSLFGGT-APIVNDWLIGKTGNTMIpaYYMMAACAVGLV 438
Cdd:COG2814 103 AARFLQGLGAGALFPAALALIADLVPPERR--GRALGLLGAGLGLGPAlGPLLGGLLADLFGWRWV--FLVNAVLALLAL 178
|
....
gi 736048739 439 ALSA 442
Cdd:COG2814 179 LLLL 182
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
79-228 |
1.04e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 39.17 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 79 FAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYASagwlapaaLIVLRMVQGFSTGGEYGGAATF 158
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAGAAL 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 159 IAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALllgdtamhAWGWRLPFLVAAPLGLIGFYLRSRL 228
Cdd:TIGR00880 76 IADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQ--------FLGWRAPFLFLAILALAAFILLAFL 137
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
279-444 |
1.40e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 279 VNYVLLAYMPTYMHkELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKtmwWISLVGLFVAAVPMFA-LMTHGVLG 357
Cdd:cd17489 11 SFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRK---RLLLIGLLIFALATLLyLLATSVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 358 AFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIaYNVSTSLFGGTAPIVNDWLIGKTGntmipaYYMMAACAVGL 437
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGY-YGLATTLAMALGPALGLFLYQHLG------FAVLFIVAAVL 159
|
....*..
gi 736048739 438 VALSAVI 444
Cdd:cd17489 160 ALLALLL 166
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
281-415 |
2.46e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 281 YVLLAYMPTYMHKELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLVGLFVAAVpmFALMTHGVLGAFV 360
Cdd:cd17333 216 TAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLL--ILLLAPTLVVGLV 293
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 361 GFAVLGLLYVPQLATISAMFPAMFPT-HVRYAGMAIAynvSTSLFGGTAPIVNDWL 415
Cdd:cd17333 294 ATALLGLFMAALFPTILSLGISNLPYaKGKGTSVLLA---AGSIGGAIIPFIMGFI 346
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
80-404 |
2.85e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 39.93 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 80 AISFLIRPLGGLFWGPLGDRLGRKRVLALtvltmSGATLLVGVLptyASAGWLAPAALIVLRMVQGFSTGGEYGGAATFI 159
Cdd:cd17361 58 SSLYLAGLVASLLASYVTRKWGRKPSMLI-----GGVLFLVGAA---LNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 160 AEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFALllgdtaMHAWGWRLPFLVAAPLGLIGFYLRSRLEETPVFRELee 239
Cdd:cd17361 130 SEMAPAKLRGALNIGFQLAITIGILIANLINYGTSK------IKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQL-- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 240 qaqrreqsAAAAALPLGRLLVRyarpllllgglvvalnvvNYVLLAYMPTYMhKELGVSENLSLLIPLLGMLAMMVLLPF 319
Cdd:cd17361 202 --------VIAILIPFFQQLTG------------------INVIMFYAPVLF-QTLGFGSDASLISAVITGAVNVVSTLV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 320 AGWLSDRVGRKTMWWISLVGLF-----VAAVPMFALMTHGVLGAFVGFAVLGLLYVPQLA------TISAMFPA-MFPTH 387
Cdd:cd17361 255 SIYLVDRFGRRFLLLEGGVQMLasqvaIGILLAVKFGDGGELPKAYAIAVVVLICLYVAAfawswgPLGWLVPSeIFPLE 334
|
330
....*....|....*..
gi 736048739 388 VRYAGMAIAynVSTSLF 404
Cdd:cd17361 335 TRSAGQSLT--VAVNFL 349
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
92-222 |
3.89e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 39.41 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 92 FWGPLGDRLGRKRVLALTVLTmsgaTLLVGVLPTYA-SAGWlapaaLIVLRMVQGFSTGGeYGGAATFIAEYAPDARRGL 170
Cdd:cd17441 53 LWGNISDQYGRKTGLKISVLW----TLYYGILSAFApIYSW-----ILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAK 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 736048739 171 CGSFLEfatlAGFSLGALLMLGFALLlgdtAMHAWGWR-LPFLVAAPLGLIGF 222
Cdd:cd17441 123 CILLIE----VFWALGTVFEVLLAVF----VMPTLGWRwLLILSALPLLIFAV 167
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
79-224 |
4.04e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.52 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 79 FAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVlptyASAGWlapaALIVLRMVQGFsTGGEYGGAATF 158
Cdd:PRK09874 60 FSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL----AQNIW----QFLILRALLGL-LGGFVPNANAL 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736048739 159 IAEYAPDARRGLCGSFLEFATLAGFSLGALLMLGFAlllgdtamHAWGWRLPFLVAAPLGLIGFYL 224
Cdd:PRK09874 131 IATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLA--------DSYGLRPVFFITASVLFLCFLV 188
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
281-441 |
5.32e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 281 YVLLAYMPTYMhKELGVSENL-SLLIPLLGmLAMMVLLPFAGWLSDRVGRKTMW----WISLVGLFVAAVPMfalmthgv 355
Cdd:cd17352 200 FVPFVYLPSYA-KSLGIDESDaAFLLSIIG-ISDIVGRILLGLLADKPRIGRLYlyifTLLILGLSLLAFPL-------- 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 356 LGAFVGFAVLGLLYVPQLATISAMFPAMFPTHVRYAGMAIAYNVST---SLFGGTAPIVNDWLIGKTGNTMIPAYYMMAA 432
Cdd:cd17352 270 ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLlfqGLAALVGPPIAGLLRDYTGDYDAAFYFCGAC 349
|
....*....
gi 736048739 433 CAVGLVALS 441
Cdd:cd17352 350 LLLSGVLLF 358
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
319-440 |
6.66e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 319 FAGWLSDRVGRKTMWWISLVGLFVAAVPMFalMTHGVLGAFVGFAVLGLLYvpqlATIS----AMFPAMFPTHVRYAGMA 394
Cdd:cd17313 300 PIGKLGKKIGRKKVYLIGLVLFAVGMALMA--LVHNVTVALVLFALGGIGW----ATINinpyPLVSDYHSESGRGQGTD 373
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 736048739 395 IA-YNVSTSLFGGTAPIVNDWLIGKTGNTMIPAyYMMAACAVGLVAL 440
Cdd:cd17313 374 TGlLNLAISLAQILVSLLAGPIIDVKGYGTVFP-VAAVASFLSLVGA 419
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
293-405 |
8.00e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 8.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 293 KELGVSENLSLLIPLLGMLAMMVLLPFAGWLSDRVGRKTMWWISLvgLFVAAVPMFALMTHGVLGAFVGFAVLGLLYVPQ 372
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY--LSLALAYLGFALGSSLWLLLLGFILWGLYMGAQ 304
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 736048739 373 LATISAMFPAMFPTHVR-------YAGMAIAYNVSTSLFG 405
Cdd:cd17370 305 ESIERAAVADLVPAELRgtayglfNTVVGIGWLLASLIAG 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
58-222 |
8.51e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 8.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 58 YISAALFPGSTASATLFALGTFAISFLIrplGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTYasagwlapAAL 137
Cdd:cd17330 22 YVREFNKLGASGYYVGLLQSSYSLGQFL---ASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL--------WLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 138 IVLRMVQGFsTGGEYGGAATFIAEYAPDARRGLCGSFLEFATLAGFSLGALLMLgfalllgdTAMHAWGWRLPFLVAAPL 217
Cdd:cd17330 91 FLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGG--------FLSTPYGYALPFLVAAAL 161
|
....*
gi 736048739 218 GLIGF 222
Cdd:cd17330 162 ALLNL 166
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
70-444 |
8.55e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 8.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 70 SATLFALGtFAISFLIRPLGGLFWGPLGDRLGRKRVLALTVLTMSGATLLVGVLPTyaSAGWLAPAALIVlrmvqGFSTG 149
Cdd:cd17355 36 SRAVISLA-FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS--LWQLYLLWGLLG-----GGGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 150 GEYGGAATFIAEYAPDARRGLCGSFLefatLAGFSLGALLMLGFALLLGDtamhAWGWRLPFLVAAPLGLIGFYLRSRLe 229
Cdd:cd17355 108 TLAAVAFATVAAWWFERRRGLALGIL----TAGGGLGSLVFLPLGAALIE----AFGWRTALLVLALLALLVLVPVLLL- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 230 etpVFRELEEQAQRREQSAAAAALPLGRLLVRYARPLLLLGGLVVALNVVNYVLLAYMPTYMhKELGVSENLSLLIPLLG 309
Cdd:cd17355 179 ---LRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736048739 310 MLAMMVLLPFAGWLSDRVGRktmWWISLVGLFVAAVPMFALM--THGVLGAFVGFAVLGLLYVPQLATISAMFPAMFPTh 387
Cdd:cd17355 255 GLFNIVGRLLSGWLGDRYSP---RRLLAASYALRALGLALLLllPFPPLALLLFAALFGLGWGATVPLTAALAARYFGA- 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 736048739 388 vRYAGMAIAYNVSTSLFGG-TAPIVNDWLIGKTGNtmipaYYMMAACAVGLVALSAVI 444
Cdd:cd17355 331 -RSYGTLFGLVFAPHQLGSaLGPWLGGLLYDRTGS-----YTAAWALAVALGLIAALL 382
|
|
| |
