|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-390 |
0e+00 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 513.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 11 CWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVV 90
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLT 170
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 171 GGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVAL 250
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 251 IAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKK 330
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 331 ITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGV 390
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
4-397 |
2.48e-119 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 353.46 E-value: 2.48e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 4 WKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRAS 83
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 84 LGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:PRK09874 92 LGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 164 KFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAG 243
Cdd:PRK09874 172 RPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 244 SLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPS 323
Cdd:PRK09874 252 NVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPA 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736016517 324 INTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGVYKKLKDH 397
Cdd:PRK09874 332 VQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQ 405
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-390 |
1.52e-67 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 218.98 E-value: 1.52e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 11 CWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVsaisqISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVV 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVA-----QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFL 169
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFTTLFFVKEDFVPSEKKKVESAK--ELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLagsLNH 247
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARlrSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL---GGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 248 VALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTL 327
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736016517 328 LKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGV 390
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-351 |
2.43e-50 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 173.24 E-value: 2.43e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL 84
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA-----GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 164 KFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLpnsnIIVTLFVSSFILQFAYYSVEPIITIYIGQLAG 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRP----RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 244 slnHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPS 323
Cdd:COG2814 240 ---LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*...
gi 736016517 324 INTLLKKITPEKFTGRIFGFNISAYYMG 351
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-388 |
1.14e-36 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 136.94 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKQlgIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGL 95
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVRE--FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 96 AQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLML 175
Cdd:cd17330 84 SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 176 IAFFTTLFFVKedfvpsekkkvesakelwkqlpnsnIIVTLFVSSFILQFAYYSVEPIITIYigqLAGSLNHVALIAGMA 255
Cdd:cd17330 164 LNLVLVLFFLP-------------------------PLRRLLLVYFLIALAFAGLESVFSLF---LKDRFGFSPSQIGLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 256 FSASGLANIIA-APRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPE 334
Cdd:cd17330 216 LALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 736016517 335 KFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYR 388
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-386 |
1.39e-34 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 131.56 E-value: 1.39e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 11 CWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVV 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA-----GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFL 169
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGaFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFttLFFvkedFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITiYIGQLAGSLNHVA 249
Cdd:cd17489 156 AAVLALLALL--LVF----LVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIST-FLPLYAAERGISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 250 liAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLK 329
Cdd:cd17489 229 --AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 330 KITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWV 386
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-386 |
5.47e-34 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.99 E-value: 5.47e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 2 KIWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLR 81
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 82 ASLGMAVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEF 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 161 LGLKFTFFLTGGLMLIAFFTTlffvkedfvpsekkkvesakelwkqlpnsniIVTLFVSSFILQFAYYSvepIITIYIGQ 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLR-------------------------------FWLLALAYFLVYFALYG---FLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 241 LAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQK--VVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATA 318
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 319 GLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWV 386
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
8-390 |
6.45e-33 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 127.34 E-value: 6.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYI-KQLGIhnvsAISQIsGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGM 86
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLhQQLGL----SASIV-GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 87 AVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFlGLKF 165
Cdd:cd17329 76 ALGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 166 TFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSl 245
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 246 nhVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSIN 325
Cdd:cd17329 234 --GESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQ 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736016517 326 TLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGV 390
Cdd:cd17329 312 TLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-356 |
6.99e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 126.76 E-value: 6.99e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQlgihNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVG 91
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAE----DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLT 170
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 171 GGLMLIAFFTTLFFVKE---DFVPSEKKKVESAKELWKQLPNSNIIVtLFVSSFILQFAYYSVEPIITIYIGQLAGSlnh 247
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPpesKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLS--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 248 vALIAGMAFSASGLANIIAAPRLGKLSDRIGPQK---VVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSI 324
Cdd:pfam07690 234 -ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 736016517 325 NTLLKKITPEKFTGRIFGFNISAYYMGTFTGS 356
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-388 |
8.97e-33 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 126.96 E-value: 8.97e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVG 91
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLV-----GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLA-----QNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKF 165
Cdd:cd06173 80 VLALLallgsLSLWLLLVLAFLLGIASAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 166 TFFLTGGLMLIAFFTTLFFVKEDFVPSEKKK---VESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLa 242
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSsllLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 243 gsLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSP 322
Cdd:cd06173 239 --LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 323 SINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYR 388
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-387 |
1.16e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 124.22 E-value: 1.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 2 KIWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNvsaiSQIsGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLR 81
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSA----AQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 82 ASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQ-TEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEF 160
Cdd:COG2223 76 GLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKwFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 161 LGLKFTFFLTGGLMLIAFFTTLFFVK---EDFVPSEKKKVESAKELWKQlPNSNIIVTLFVSSFILQFAYYSVEPiiTIY 237
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRdppAGAAAAAKASLRDQLEALRD-PRFWLLSLLYFGTFGSFIGFSSWLP--PYL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 238 IGQLAGSLNHVALIAGMAfsasGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFV-KNPWQLMALRFGLGIA 316
Cdd:COG2223 233 VDQFGLSAATAGLLAALF----ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 317 TAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLG-IKYVFFITSSLLFFNAIWVY 387
Cdd:COG2223 309 LGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-388 |
4.76e-31 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 122.29 E-value: 4.76e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 13 FGTFVTLIGMSQIAPIMPLYIKQLGIhnvsAISQIsGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLrASLGMAVVVGS 92
Cdd:cd17474 6 FATLLAVLGVSIVDPILPAIAEALGA----SPAQV-GLLITAFTLPAAVLMPVAGVLADRFGRKKVLL-PGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 93 M-GLAQNVYQLIGLRILQGV--ITGYSTACTTLVATQTEKKHAGwALGVLSTAFVSGSLLGPLVGGYLDEFlGLKFTFFL 169
Cdd:cd17474 80 LcGLSDSFALLLAGRALQGIgaAGLGPLALTLIGDLFEGGERAK-AMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFTTLFFVKEDfVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLnhvA 249
Cdd:cd17474 158 LAALIPVAFLAILFLLPEP-KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS---P 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 250 LIAGMAFSASGLANIIAAPRLGKLSD-RIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLL 328
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 329 KKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYR 388
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-386 |
1.28e-29 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 118.04 E-value: 1.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGGLMLIAFFTTLFFVKEdfVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLN 246
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLPS--LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 247 HVAliaGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINT 326
Cdd:cd17324 234 SAI---IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 327 LLKKITPEKfTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWV 386
Cdd:cd17324 311 RVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-387 |
1.95e-27 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 112.28 E-value: 1.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPlyikQLGIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALP----AIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEfLGLKFT 166
Cdd:cd17473 77 IGGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGgLMLIAFFTTLFFVKEDfVPSEKKKVESAKELWKQLPNSNIIVtLFVSSFILQFAYYsvepIITIYIGQLAGSLN 246
Cdd:cd17473 156 FLVYL-LALPVLILVLLFLPEP-ARKSKSAASPGAATAAALPWKRVLP-IYFLAFLAMLLFY----VIPIQLPFLLQERG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 247 HV-ALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSIN 325
Cdd:cd17473 229 GGsAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLN 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736016517 326 TLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQI-AAHLGIKYVFFITSSLLFFNAIWVY 387
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-384 |
1.15e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 107.13 E-value: 1.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVG 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQL-----GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKF-TFFL 169
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWrAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFTTLFFVKEDFVPSEKKKVESAK-----ELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGS 244
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASsksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 245 lnhVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGA-LILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPS 323
Cdd:cd06174 237 ---SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 324 INTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQI-AAHLGIKYVFFITSSLLFFNAI 384
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
8-185 |
7.61e-25 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 105.04 E-value: 7.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGiHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLM-GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGVITGYSTAC-TTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLATGGLLPAiNSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAV 361
|
170
....*....|....*....
gi 736016517 167 FFLTGGLMLIAFFTTLFFV 185
Cdd:cd17391 362 FVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-185 |
3.13e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 3.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAIsqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL 84
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170 180
....*....|....*....|..
gi 736016517 164 KFTFFLTGGLMLIAFFTTLFFV 185
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-403 |
1.83e-23 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 101.90 E-value: 1.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 19 LIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFG-----RKPMLLRASLGMAVVVGSM 93
Cdd:COG2211 24 LAFGLLSAYLLYFYTDVLGLSAALV-----GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 94 -------GLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKH-----AGWALGVLSTAFVSGSLLGPLVGGYL--DE 159
Cdd:COG2211 99 ftapdlsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEertrlSSWRFAFAGLGGLLASVLPPPLVAAFggDA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 160 FLGLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKveSAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIG 239
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV--SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 240 QLagsLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVK--NPWQLMALRFGLGIAT 317
Cdd:COG2211 257 YV---LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 318 AGLSPSINTLLKKITPE---KFTGRIFGFNISAYYMGTFTGSVIGGQIA------------------AHLGIKYVFFITS 376
Cdd:COG2211 334 GAILVLPWAMLADVVDYdewKTGRRREGLYFGIFTFAIKLGQALAGALAglllalfgyvagaaqspsALTGIRLLFFLLP 413
|
410 420
....*....|....*....|....*..
gi 736016517 377 SLLFFNAIWVYRGVYKKLKDHDKISEA 403
Cdd:COG2211 414 AVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-366 |
1.90e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 100.71 E-value: 1.90e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 13 FGTFVTLIGMSQIAPIMPLYIKQLGIhnvsAISQISgIAFGATFVVSAIFSPIWGYVADRFGRKPMLLrasLGMAV-VVG 91
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGA----SPSQLQ-WVVNAYLLAFAALLLLAGRLGDRFGRKRVFL---IGLALfGLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 S--MGLAQNVYQLIGLRILQGVITGYSTACTT-LVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFF 168
Cdd:cd17321 75 SllCALAPSLAFLIAARALQGIGAAAIMPASLaLIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 169 LTGGLMLIAFFTTLFFvkedfvpsekkkvesakelwkqlpnsniiVTLFVSSFILQFAYYSVEPIITIYigqLAGSLNHV 248
Cdd:cd17321 155 INVPIGLVALLLARTF-----------------------------SGAVLAAFLLGAALGGLLFLLPLY---LQGVLGYS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 249 ALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGL----SPSI 324
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLglfaTPLT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 736016517 325 NTLLKKITPEKfTGRIFGFNISAYYMGTFTGSVIGGQIAAHL 366
Cdd:cd17321 283 NAALSSVPKEK-AGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
19-378 |
2.09e-23 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 100.75 E-value: 2.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 19 LIGMSQIAPIMPLYIKQLGihnvSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLrasLGMAV-VVGSM--GL 95
Cdd:cd17472 9 MLGMFLVLPVLSVYAKSLP----GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVIL---FGLLLfIAGSLlaAY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 96 AQNVYQLIGLRILQGvITGYSTACTTLVATQTEKKHAGWALGVLST----AFVSGSLLGPLVGGyldeFLGLKFTFFLTG 171
Cdd:cd17472 82 ATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALIGAsigiAFAISMVLGPLLAA----HLGVSGLFLITA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 172 GLMLIAFFTTLFFVKEDfvPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALI 251
Cdd:cd17472 157 ILSLVSLLILLFFVPDP--PKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAAprlgKLSDRIGPQKVVLGALIL----AGIVFIpqAFVKNPWQLMALRFGLGIATAGLSPSINTL 327
Cdd:cd17472 235 YLPAILIGFILMVPFV----IYAEKKGKMKQVFVSSILliavGFLLLL--FAATSLWLLIIGLIIFFIGFNLLEALLPSL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 736016517 328 LKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSL 378
Cdd:cd17472 309 VSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILIL 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-386 |
6.91e-22 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 96.07 E-value: 6.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQLGIhNVSAIsqisGIAFGATFVVSAIFSPIWGYVADRFG-RKPMLLRASLGMAVVVGSMGLAQNVYQLI 103
Cdd:cd17370 18 ARSILPLFLVVLGA-SAAAV----GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 104 GLRILQGVITGYSTACT-TLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKF-TFFLTGGLMLIAFFTT 181
Cdd:cd17370 93 LLRILERLGKGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYrTIFLLAAIPALLALLI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 182 LFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVssFILQFAYYSVePIITIYIGQLAGSlnhvALIAGMAFSASGL 261
Cdd:cd17370 173 LLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAV--ALFALGNFSF-AFLILRAQELGLS----AALIPLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 262 ANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIF 341
Cdd:cd17370 246 VYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAY 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 736016517 342 GFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWV 386
Cdd:cd17370 326 GLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
217-395 |
2.97e-21 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 94.64 E-value: 2.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 217 FVSSFILQFAYYSVEPIITIYIGQLaGSLNH--VALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVF 294
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQL-GVTSGglVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 295 IPQAFVKNPWQLMALRFGLGIATaGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFS-GYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
170 180
....*....|....*....|.
gi 736016517 375 TSSLLFFNAIWVYRGVYKKLK 395
Cdd:cd17391 160 TGGLLFLAFLLTLFFVKEDFK 180
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-364 |
3.53e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 94.18 E-value: 3.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 13 FGTFVTLIGMSQIAPIMPLYIKQLGIhNVSAISQIsgiaFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGS 92
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGT-SAAAVSWV----LTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 93 MGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGG 172
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 173 LMLIAFFTTLFFVKEDFvpsekkkvesakelwkqlpNSNIIVTLFVSSFILQFAYYSVePIITIYIGQLAGSL--NHVAL 250
Cdd:cd17504 158 VAVLLAALVPLIDLRLL-------------------RRRNVLLANITALLAGFGMFMV-FQLLPQLLQLPTPTgfGLGIT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 251 IAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFV-KNPWQLMALRFGLGIATAGLSPSINTLLK 329
Cdd:cd17504 218 EAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNIVV 297
|
330 340 350
....*....|....*....|....*....|....*
gi 736016517 330 KITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAA 364
Cdd:cd17504 298 ESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-292 |
9.48e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.80 E-value: 9.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHnvsaiSQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL 84
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGAS-----SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 164 KFTFFLTGGLMLIAFFTTLfFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAG 243
Cdd:COG0477 168 RWIFLINAPLGLLALVLRL-RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 736016517 244 SLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGI 292
Cdd:COG0477 247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
25-386 |
3.32e-20 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 91.49 E-value: 3.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQLGIhNVSAIsqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGL--AQNVYQL 102
Cdd:cd17335 16 LLPFLSVYLKQLGL-SPTQI----GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFfvAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 103 IGLRILQGVItgySTACTTLV-----ATQTEKKH----------AGWALGVLstafvsgsLLGPLVgGYLDEFLGLKFTF 167
Cdd:cd17335 91 LLLVILGAFF---SAPVVPLVdsitlQYLGEERErygkqrlwgsIGFGIAAL--------LVGILI-DRSSTYKNYTIAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 168 FLTGGLMLIAFFTTLFFvkeDFVPSEKKKVESAKELWKQLPNSNIIVTLFVsSFILQFAYYSVEPIITIYIGQLAGSlnh 247
Cdd:cd17335 159 YVFAVLMLLALLLALKF---PFRPKHPEPNENTGGLLALLRNPRVLAFLLV-AFLMGFGHGLIYSFLFWHLQDLGGS--- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 248 vALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTL 327
Cdd:cd17335 232 -KTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSY 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 328 LKKITPEKFTGRIFGFNISAYY-MGTFTGSVIGGQIAAHLGIKYVFFITS--SLLFFNAIWV 386
Cdd:cd17335 311 ASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAiaALAGLLAFFL 372
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
27-388 |
4.68e-20 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 91.13 E-value: 4.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 27 PIMPLYIKQLGIhNVSAISQISGiAFGATFVVSAIfsPIwGYVADRFGRKPMLLRASLgMAVVVGS--MGLAQNVYQLIG 104
Cdd:cd17490 17 PFLSPYAESLGA-SLSMIGIILG-AYGISQMLLRI--PL-GILSDRIGKRKLFIIIGL-LFTVLASliMILFPSPWGLLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 105 LRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:cd17490 91 ARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 185 VKEDfvPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANI 264
Cdd:cd17490 171 KEER--REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 265 IAAPrlgKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFN 344
Cdd:cd17490 249 LSGT---LFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFF 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 736016517 345 ISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYR 388
Cdd:cd17490 326 QAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
16-346 |
6.39e-20 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 90.77 E-value: 6.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTL----IGMSQIAPIMPLYIKQLGIHnVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVG 91
Cdd:cd17388 5 LVTVlldaMGIGLIMPVLPTLLREFVGD-SADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLAQNVYQLIGLRILQGvITGYS--TACTTLVATQTEKKHAGWaLGVLSTAFVSGSLLGPLVGGYLDEFlGLKFTFFL 169
Cdd:cd17388 84 LMAFAPTLWWLYLGRIIAG-ITGATgaVAAAYIADVTPPEQRARN-FGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFTTLFFVKEDfVPSEKKKVESAKEL-----WKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQ-LAG 243
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPES-LPPERRRAFRWRRAnpfgsLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDrFDW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 244 SLNHValiaGMAFSASGLANIIA-APRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWqlMALRFGLGIATAGLS- 321
Cdd:cd17388 240 SPTMV----GLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGW--MVFPILILLALGGIAg 313
|
330 340
....*....|....*....|....*
gi 736016517 322 PSINTLLKKITPEKFTGRIFGFNIS 346
Cdd:cd17388 314 PALQGLLSRQVPENEQGELQGVLTS 338
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-390 |
8.18e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.03 E-value: 8.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 212 IIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAG 291
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGAS----PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 292 IVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYV 371
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170
....*....|....*....
gi 736016517 372 FFITSSLLFFNAIWVYRGV 390
Cdd:COG2814 167 FLVNAVLALLALLLLLRLL 185
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-384 |
1.92e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 89.15 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 13 FGTFVTLIGMSQIAPIMPLYIKQLGIhnvsaISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGS 92
Cdd:cd17478 3 LGHFLNDFYQGFLPALLPLLIAKLGL-----SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 93 MGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL-DEFLGLKFTFFLTG 171
Cdd:cd17478 78 LGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALvALFGGLGLLILLII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 172 GLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQlpNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALI 251
Cdd:cd17478 158 PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKG--VWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAaprlGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWqLMALRFGLGIATAGLSPSINTLLKKI 331
Cdd:cd17478 236 LSLFLFAGAIGTLIG----GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW-SYILLVLAGFLLFASFPVTVVLAQEL 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 332 TPEKF---TGRIFGFNISayyMGTFTGSVIGGqIAAHLGIKYVFFITSSLLFFNAI 384
Cdd:cd17478 311 LPGNVglaSGLMMGLSFG---LGGIGAPVLGA-LADAFGLESVLLILALLPLLGAL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-388 |
2.30e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 2.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL 84
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA-----GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATqTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL---DEF 160
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLgLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLillGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 161 LGLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSniivtLFVSSFILQFAYYSVEPIITIYIGQ 240
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNP-----RLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 241 LAGSLNHV-ALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAG 319
Cdd:COG0738 236 YLKDVLGLsEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 320 LSPSINTLLKKITPeKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITS---SLLFFNAIWVYR 388
Cdd:COG0738 316 MFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLvcyLLILLLALALKR 386
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-386 |
2.12e-18 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 86.07 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 13 FGTFVTLIGMSQIAPIMPLyikQLGIHNVSAisQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGS 92
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSL---RLEREGVST--ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 93 MGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLglkFTFFLTG 171
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG---ALPFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 172 GLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNsnIIVTLFVSSFILQfAYYSVEPIITIyigqlagSLNHVALI 251
Cdd:cd17477 155 AVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPL--ALLGAFVAGFLEG-AFYSLLPLYGL-------RLGLSVAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKN-PWQLMALRFGLGIATAGLSPSINTLLKK 330
Cdd:cd17477 225 AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGlPLALLVLLFLWGGAAGPLYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 331 ITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWV 386
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-327 |
4.44e-18 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 85.32 E-value: 4.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 20 IGMSQIAPIMPLYIKQLGIHnvSAISQISgiaFGATFVVSAIFSPIWGYVADRFGRKPMLLrasLGMAV-VVGSMG--LA 96
Cdd:cd17320 13 LAIDMYLPALPAIARDLGAS--ASAVQLT---LSAYLLGFALGQLLYGPLSDRFGRRPVLL---AGLLLfILASLLcaLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 97 QNVYQLIGLRILQGVitgysTACTTLVATQT------EKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLT 170
Cdd:cd17320 85 SSIEQLLIARFLQGL-----GAAAGSVVARAivrdlySGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 171 GGLMLIAFFTTLFFVKE-----DFVPSEKKKVESAKELWKQLP-NSNIIVTLFVSSFIlqFAYYSVEPIitIYIGQLAGS 244
Cdd:cd17320 160 ALLGLLLLLLVLLFLPEtlpeeKRKPLLSSLLRAYKRVLKNRRfLGYALALGLSFAGL--FAYLAAAPF--IYIEQLGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 245 LNHVALIAGMAFSASGLANIIAaprlGKLSDRIGPQKVV---LGALILAGIVFIPQAFVK--NPWQLMALRFGLGIATAG 319
Cdd:cd17320 236 PAQFGLLFALNAIALILGSLLN----GRLVRRFGPRRLLrlgLLLLLAAALVLLLAALLGglSLWPLVAPLFLIFFGFGL 311
|
....*...
gi 736016517 320 LSPSINTL 327
Cdd:cd17320 312 IFPNATSL 319
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
57-327 |
9.70e-18 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 84.16 E-value: 9.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 57 VVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYST-ACTTLVATQTEKKHAGWA 135
Cdd:cd17503 42 LALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 136 LGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFvkeDFvpsekkkvesakelwKQLPNSNIIVT 215
Cdd:cd17503 122 MGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL---DL---------------RLFKDRNFTLG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LfVSSFILQFAYYSVEPIITIYIGQLAGslnHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17503 184 L-LLSFLLGLGLFGAMFLLPLYLQNVLG---YSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
250 260 270
....*....|....*....|....*....|....*
gi 736016517 296 PQAFV---KNPWQLMALRFGLGIATAGLSPSINTL 327
Cdd:cd17503 260 LLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-381 |
1.10e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 83.81 E-value: 1.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPlYIKQLGIHNVSAIsqISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAP-VLAAEFSLGLSLL--QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL----DEFLG 162
Cdd:cd17316 78 LATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 163 LKFTFFLTGGLMLIAFFttlffvkedfvpsekkkvesakeLWKqlpnsnIIVTLFVSSFILQFAYYsvePIITIYIGQLA 242
Cdd:cd17316 158 WRILFLIGALPALLALL-----------------------LRR------RTLLLILLWFFISFGYY---GLTTFLPTYLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 243 GSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIP--QAFVKNPWQLMALRFGLGIATAGL 320
Cdd:cd17316 206 TVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGV 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736016517 321 SPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFF 381
Cdd:cd17316 286 WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
26-367 |
1.39e-17 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 83.81 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 26 APIMPLYIKQLGIHNVSaisqisgiaFGA---TF-VVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQ 101
Cdd:cd17331 20 QPVLPYLTKKLGVDSVV---------FGYlqtTFsVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 102 LIGLRILQGVITGYSTAcTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTT 181
Cdd:cd17331 91 LFLSRLPSVFMHAMQAA-QMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 182 LFF------VKEDFVPSEKKKVESAKELWK-----QLPN-SNIIVTLFVSSFILQFaYYSVEPIITIYIGQLAGSLNhva 249
Cdd:cd17331 170 ILLipsntkSKREKEAKESASPPSVFNLKEilrllRLPGvAFLLLVKLLSGLPIGM-FQSMFSLVAMDFFGLTPEEN--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 250 liaGMAFSASGLANIIA-APRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLL 328
Cdd:cd17331 246 ---GYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLL 322
|
330 340 350
....*....|....*....|....*....|....*....
gi 736016517 329 KKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLG 367
Cdd:cd17331 323 TKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG 361
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
44-367 |
1.74e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 83.47 E-value: 1.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 44 ISQISGiAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIglrILQGVITGYSTACTTLV 123
Cdd:cd17355 37 RAVISL-AFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY---LLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 124 ATQT-----EKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF-----VKEDFVPSE 193
Cdd:cd17355 113 AFATvaawwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLlrrrpADLALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 194 KKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKL 273
Cdd:cd17355 193 DASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGIS----PAAAAVALALIGLFNIVGRLLSGWL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 274 SDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMAL-RFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGT 352
Cdd:cd17355 269 GDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGS 348
|
330
....*....|....*
gi 736016517 353 FTGSVIGGQIAAHLG 367
Cdd:cd17355 349 ALGPWLGGLLYDRTG 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
216-403 |
4.59e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.70 E-value: 4.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQlagSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAE---DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFIT 375
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180
....*....|....*....|....*...
gi 736016517 376 SSLLFFNAIWVYRGVYKKLKDHDKISEA 403
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEE 185
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-343 |
5.65e-17 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 82.12 E-value: 5.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 28 IMPLYIKQL-----GIHNVSAISQISGIAFgatfVVSAIFSPIWGYVADRFG-RKPMLLRASLGMAVVVGSMGLAQNVYQ 101
Cdd:COG2270 33 VFPPYFTSVaalgdPAAATALWGYALAIAG----LLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAALFFVAPGGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 102 LIGLRILQGVITGYSTACT----TLVATQTEKKH-----AGWALG----VLSTAFVSGSLLGPLVGGYLDEFLGLKFTFF 168
Cdd:COG2270 109 WLGLLLFVLANIGFEGSLVfynaFLPDIATPEEIgrvsgLGWALGylggVLLLLINLALFLKPEAFGLPDAGEAVRISFL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 169 LTGGLMLIAFFTTLFFVKEDFVPSEKKK----VESAKELW---KQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQL 241
Cdd:COG2270 189 LTALWWLLFALPLFLFLPERPRPGPAPPrgavRAGFRELRrtlRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 242 AG-SLNHVaLIAGMafsasgLANIIAAPR---LGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIAT 317
Cdd:COG2270 269 LGfSTTEL-IVFGL------LVQIVAALGallFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVM 341
|
330 340
....*....|....*....|....*.
gi 736016517 318 AGLSPSINTLLKKITPEKFTGRIFGF 343
Cdd:COG2270 342 GGIQALSRSLLARLIPPGREAEFFGL 367
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-360 |
1.58e-16 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 80.86 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 4 WKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGAtfVVSAIFSpiwGYVADRFGRKPMLLRAS 83
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGM--AFGALFF---GPLADRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 84 LGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLG 162
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 163 LKFTFFLTGGLMLIAFFTTLFFVKE------------------DFVPSEKKKVESAKELWKQLPN--------------S 210
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpetvrrivnAIAPQMQAEAQSALPEQKSTQGtkrsvfkalfqgktA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 211 NIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNhVALIAGMAFSASGLANIIAAprlGKLSDRIGPQKVVLGALILA 290
Cdd:TIGR00895 250 RITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLS-LAATGGALFNFGGVIGSIIF---GWLADRLGPRVTALLLLLGA 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 291 GIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGG 360
Cdd:TIGR00895 326 VFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
216-391 |
1.92e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 80.30 E-value: 1.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFIT 375
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170
....*....|....*.
gi 736016517 376 SSLLFFNAIWVYRGVY 391
Cdd:COG2271 171 GLPGLLLALLRFWLLA 186
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-187 |
2.50e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 75.38 E-value: 2.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 57 VVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYS-TACTTLVATQTEKKHAGWA 135
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFAlVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 736016517 136 LGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKE 187
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
53-316 |
1.27e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 78.05 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 53 GATFVVS-AIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKK 130
Cdd:cd17328 40 QTVFIISyMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 131 HAGWALGVLSTAFVSGSLLGPLVGGYL-DEFLGLKFTFFLTGGLMLIAFFTTLFFVKE------DFVPSEKKKVESAKEL 203
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVREpprgaaEGGVMAKSTATSFLAD 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 204 WKQLPNSNIIVTLFVSSFILQFAYYS----VEPIITIYIGQLAGSLNHVALIAGMAFSASGLANI----IAAPRLGKLSD 275
Cdd:cd17328 200 LKALAKNPSFILSTLGFTAVSFVTGAlafwAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVllggILADRLRRKTP 279
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 736016517 276 RIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIA 316
Cdd:cd17328 280 RADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEF 320
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
16-362 |
3.24e-15 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 76.50 E-value: 3.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKQLGIHNVsaISQISGIAFGATFVVSaifSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGL 95
Cdd:cd17390 6 FLDLFGVSMILPLLSTHIRSLGASPT--VIGLIGSVYGALQLFS---SPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 96 AQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEflglkftffLTGGLML 175
Cdd:cd17390 81 STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAE---------TDGGFYY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 176 IAFFTTLFFVKedfvpsekkkveSAKELWKQLPNSNIivtLFVSSFILQFA---YYSVEPIITIYIGQLAgslnhvALIA 252
Cdd:cd17390 152 VALLCSAIFIL------------NAGLVWFLLSKLWD---LLLVRFLMGFSvllFRSNFSLYLEERFDLS------PKTI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 253 GMAFSASGLANIIAAPRLGKLSDRIG--PQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKK 330
Cdd:cd17390 211 GYLISYSGVLGALSGFLVGRILKLYKnnEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLS 290
|
330 340 350
....*....|....*....|....*....|..
gi 736016517 331 ITPEKFTGRIFGFNISAYYMGTFTGSVIGGQI 362
Cdd:cd17390 291 RGKSKERGTLLGVGQSVTSLARILAPLLSGLL 322
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
25-367 |
1.04e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIG 104
Cdd:COG2807 37 VGPLLPEIRADLGLSATQA-----GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 105 LRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 185 VKEDfvPSEKKKVESAKELWKQLPNSNI-IVTLFvssFILQ-FAYYSVepiiTIYIGQLAGSLNHVALIAGMAFSASGLA 262
Cdd:COG2807 192 LRRR--PAAAAAAPAAASLRSLWRSPLAwLLTLF---FGLQsLLYYAV----VAWLPPILRDAGLSAATAGLLLSLFQLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 263 NIIAAPRLGKLSDRIGPQK---VVLGALILAGIVFIPQAFVKNPWQLMALrfgLGIATAGLSPSINTLLKKITP-EKFTG 338
Cdd:COG2807 263 GIPGSLLVPLLADRLGDRRpllLLLGLLGLAGLLGLLLAPGSLPWLWAVL---LGLGQGGLFPLALTLIGLRARtPAEAA 339
|
330 340
....*....|....*....|....*....
gi 736016517 339 RIFGFNISAYYMGTFTGSVIGGQIAAHLG 367
Cdd:COG2807 340 ALSGMAQSVGYLLAALGPLLVGALHDATG 368
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-374 |
1.19e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 74.89 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 15 TFVTLIGMSQIAPIMPLY-IKQLGIhnvsaisqiSGIAFGATFVVSAIF----SPIWGYVADR-FGRKPMLLRASLGMAV 88
Cdd:cd17471 5 TLLTGLAGAFVLPYLSLFlTEELGA---------SPLQIGIFMTLSALSgivvSQWLGRLSDRgGDRKPLILLALLAGAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 89 VVGSMGLAQNVYQLIGLRIlqgVITGYSTACTTL-------VATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFL 161
Cdd:cd17471 76 GYLLFAFLRNYWVLLLVGV---VLLSLGAAAFPQlfalareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 162 GLKFTFFLTGGLMLIAFFTTLFFVKEdfVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFIL--QFAYYSVEPIitiYIG 239
Cdd:cd17471 153 GFTGLFLLAALLYLVVALLVLFLLPS--VKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFaaNSMYIIAMPL---YVT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 240 Q-LAGSLNHVALIAGMAfsasGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRF--GLGIA 316
Cdd:cd17471 228 NeLGGSESWVGLLFGLA----AALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLlnAIFIG 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736016517 317 -TAGLSPSIntlLKKITPEKfTGRifgfnISAYYM-----GTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17471 304 iTAGLGISY---FQDLMPGQ-PGL-----ATTLYSnasriGSLLGGLLAGVIAQYFGYRAVFLV 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-379 |
1.65e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.14 E-value: 1.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 49 GIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVI-TGYSTACTTLVATQT 127
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 128 EKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEdfvpsekkkvesakelwkql 207
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ-------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 208 pnsniIVTLFVSSFILQFAYYSVEPIITIYIGQLAG-SLNHVALIAGMAFSASGLANIIAaprlGKLSDRIGPQ---KVV 283
Cdd:cd17319 181 -----VWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILG----GRLSDRLLRGarrLVI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 284 LGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIA 363
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
330
....*....|....*.
gi 736016517 364 AHLGIKYVFFITSSLL 379
Cdd:cd17319 332 DATGSYTAAFLFLAAV 347
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-384 |
1.90e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.57 E-value: 1.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 48 SGIAFGATFVVSAIFSPIWGYVADRFG-RKPMLLraslGMAVVVGSMGLAQNVYQLIGLRILQGVITG------YSTACT 120
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGpRKAILI----GGILFGLGFILSAFAISLPLLFLGYGVLGGigagigYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 121 TLVATQTEKKhaGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVK---EDFVPSEKKKV 197
Cdd:cd17353 116 TAVKWFPDKR--GLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRdppKGWVPPGVDPL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 198 ESAKEL------WKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhVALIAGMAFSASGLANIIAAPRLG 271
Cdd:cd17353 194 ANNAENsprdytPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGL---DAGIAALAVSILSIFNGGGRPFWG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 272 KLSDRIGPQKVVLGALILAGIVFIPQAFV-KNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYM 350
Cdd:cd17353 271 WLSDKIGRKNTLSIAFLIQGVAMFLLPFIgSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGV 350
|
330 340 350
....*....|....*....|....*....|....
gi 736016517 351 GTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAI 384
Cdd:cd17353 351 GGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALA 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
212-388 |
4.46e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.15 E-value: 4.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 212 IIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIagmaFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAG 291
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWI----VSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 292 IVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYV 371
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170
....*....|....*..
gi 736016517 372 FFITSSLLFFNAIWVYR 388
Cdd:COG0477 171 FLINAPLGLLALVLRLR 187
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
42-391 |
9.51e-14 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 72.17 E-value: 9.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 42 SAISQISGIA-FGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNvYQLIG---------LRILQGV 111
Cdd:cd17369 39 PAAGTLAAFAtFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPT-YAQIGilapillvlLRLLQGL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 112 ITG--YSTAcTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLV----GGYLDE--FL--GLKFTFFLTGGLMLIAFF-- 179
Cdd:cd17369 118 ALGgeWGGA-VLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVflllSALLSDeaFLswGWRIPFLLSAVLVAVGLYir 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 180 -----TTLFfvkEDFVPSEKKKVESAKELWKQLPNSNIIVTLfvssfiLQFAYYSVEPIITIY-IGQLAGSLNH---VAL 250
Cdd:cd17369 197 lrleeTPVF---RRAKEAGQVVRAPLVEVLRRHWRALLLAIG------LRLAENVLFYLFTTFaLSYATQTLGVdrsTVL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 251 IAGMAFSASGLANIIAAprlGKLSDRIGPQKVVLGALILAGIVFIPQAFV----KNPWQLMALRFGLGIATAGLSPSINT 326
Cdd:cd17369 268 LAVLIASVVAAITIPLF---GWLSDRVGRRPVYLAGALLAALFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQAA 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736016517 327 LLkkitPEKFTGRIfgfnisayymgTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGVY 391
Cdd:cd17369 345 FL----AELFPTRV-----------RYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALY 394
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
216-388 |
1.28e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.86 E-value: 1.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFsasgLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFT----LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFIT 375
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170
....*....|...
gi 736016517 376 SSLLFFNAIWVYR 388
Cdd:cd17489 157 AVLALLALLLVFL 169
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
15-381 |
4.88e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 70.13 E-value: 4.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 15 TFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISgIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMG 94
Cdd:cd17314 8 SFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIA-TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 95 LAQNVYQL-IGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGL 173
Cdd:cd17314 87 YVFNSFPLsYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 174 ML--IAFFTTLFFVKEDFVPSE----KKKVESAKELWKQlPNSNIIVTLFVSSFILQFayysvepIITIYIGQLAGSLN- 246
Cdd:cd17314 167 AAivLSVVSLLGFKEPPDNQARlhvqKKKTQTMGEIFRD-KVFWILFIAIFLVLIGGF-------LFIANMASLVRSLQl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 247 -HVALIAGMaFSASGLANIIAAPRLGKLSDRIGPQ---KVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSP 322
Cdd:cd17314 239 dAPSFVTKL-MSIYGLFNAFGRLLWGIVADFFGGRlstLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 323 SINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHL-GIKYVFFITSSLLFF 381
Cdd:cd17314 318 VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYISAVYIYAVIVFL 377
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
8-374 |
5.50e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 69.54 E-value: 5.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQL-----GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGVITGYSTAC-TTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd17365 76 LFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNaITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGGLMLIAF---FTTLffvkedfvpsekkkvesakelwkqlpnsniivTLFVSSFILQFAYYSVEPIITIYIGQLAG 243
Cdd:cd17365 156 FLLGGVPPLILLpllRGTL--------------------------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 244 SLNHvALIAGMAFSASGLANIIAaprLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLM-ALRFGLGIATAGLSP 322
Cdd:cd17365 204 SLSQ-ALTITLLLNIGGVIGSLL---LGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLyVLVFLAGACVNGAQV 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 736016517 323 SINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQ-IAAHLGIKYVFFI 374
Cdd:cd17365 280 GLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAGLGPESVFLA 332
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
8-190 |
5.85e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 69.91 E-value: 5.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHnvsaiSQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVS-----EEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGVI--TGYSTACTTlVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKF 165
Cdd:cd17323 76 IFQIGCALAPNIAMLIILRFLQGFFgsSPLAIGAGT-IADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRW 154
|
170 180
....*....|....*....|....*
gi 736016517 166 TFFLTGGLMLIAFFTTLFFVKEDFV 190
Cdd:cd17323 155 IFWFLAIISGFCLILIFLFLPIVLL 179
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
253-390 |
1.18e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 68.75 E-value: 1.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 253 GMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKIT 332
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 333 PEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGV 390
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL 178
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
12-384 |
1.44e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 68.36 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQLGihnvsAISQISGIaFGATFVVSAIFSPIWGYVADRFGRKPMLLrasLGMAV-VV 90
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFG-----GLSLVSWV-GTAYLLTSTAFQPIYGKLSDLFGRKWVLL---IAIVIfEL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSM--GLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTF 167
Cdd:cd17502 73 GSLlcGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 168 FL---TGGLMLIaffttlffvkedFVPSekkkvesakelwkqlPNSNIIVTLFVSSFILQFAYYsvepiITIYigqLAGS 244
Cdd:cd17502 153 YInlpIGGLALA------------LLRT---------------ILLSSIFGFLFGGALFGLIYY-----LPLY---FQLV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 245 LNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQK--VVLGALI--LAGIVFIPQAFVKNPWQLMALRFGLGIATAGL 320
Cdd:cd17502 198 LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILmsVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIG 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736016517 321 SPSINTLLKKITPEKFTGRIFGFNisayYMGTFTGSVIGgqiaahLGIKYVFFITSSLLFFNAI 384
Cdd:cd17502 278 FQQPLVAVQNAVPPADVGVATATN----TFFRSLGGTLG------VAITDVFLVALALAALAFL 331
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-374 |
2.65e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 67.73 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 11 CWFGTFVTLIGMSQIAPIMPLYIKQLGIhNVSAISQISgIAFGATFVVSAIFSpiwGYVADRFGRKPMLLRASLGMAVVV 90
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNL-NVADVSVIF-SSQNAGYLIGSLLA---GFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL-DEFLGLKFTFFL 169
Cdd:cd17333 76 ALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIAFFTTLFFVKEDFVPS-EKKKVESAKELWKQLPNSNIIVTLFVssfILQFAYYSVEPIITIYIGQLAGSLNHV 248
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSArNPQQSVGAFSASASRLLRNPSIILGA---LALFLYVGAETAFSSWVPSYLVEKKHV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 249 ALIAgMAFSASGLANIIAAPRL--GKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINT 326
Cdd:cd17333 233 SDGL-AGYLLSGFWVGITIGRLlgGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 736016517 327 LLKKITPEKfTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17333 312 LGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
221-390 |
8.50e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 66.30 E-value: 8.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 221 FILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFV 300
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 301 KNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGI--KYVFFITSSL 378
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAAL 161
|
170
....*....|..
gi 736016517 379 LFFNAIWVYRGV 390
Cdd:cd06174 162 ALLAAILLLLVV 173
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
8-337 |
8.98e-12 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 66.63 E-value: 8.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGihnvSAISQISGIAFGaTFVVSAIFSPIWGYVADRFGRKPMLLRASLGMA 87
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLG----SSLSQVQWVITS-YMLANAISIPLTGWLAKRFGTRRLFLISTFAFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGVITGYSTACT-TLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:TIGR00711 79 LGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSfSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGGLMLIAFFTTLFFVKEDfVPSEKKKV--------------------ESAKELWKqlpNSNIIVTL---------- 216
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPRD-KPAASENFdflgllllsvglgsllyglsEGPERGWF---DSNEILILsitglvaiia 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 217 --------------------------FVSSFILQFAYYSVEPIITIYIGQLAGslnHVALIAGMAFSASGLANIIAAPRL 270
Cdd:TIGR00711 235 fvvweltddnplvdlrlfkyrnftigCVYMSLLGLGLYGSFYLLPLYLQQVLG---YTALQAGLHILPVGLAPMLSSPIA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 271 GKLSDRIGPQKVVLGALILAGIVFIPQAFVKNP----WQLMALRFGLGIATAGLSPSINTL-LKKITPEKFT 337
Cdd:TIGR00711 312 GRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTPdtpfLAIALPQFIRGFGMGCFFMPLTTIaLSGLPPHKIA 383
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
25-380 |
9.04e-12 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 66.06 E-value: 9.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQlgihNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFG-RKPMLLrASLGMAVVVGSMGLAQNVYQLI 103
Cdd:cd17384 19 VVPIIPDYLNE----NVRV-----GLLFASKALVQLITNPIVGPLTNRIGySLPMFV-GFVIMFISTLLFAFGESYGVLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 104 GLRILQGVitgySTACTT-----LVATQ-TEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIA 177
Cdd:cd17384 89 LARALQGV----GSACSSvagmgMLASLyPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 178 FFTTLFFVKedfvPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYigqLAGSLNHVALIAGMAFS 257
Cdd:cd17384 165 GALQLFILQ----PSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIW---MMETMCPPKWQLGTAFL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 258 ASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGI--VFIPQAfvKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEK 335
Cdd:cd17384 238 PDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGIslILIPLA--KNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLR 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 736016517 336 FT---GRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLF 380
Cdd:cd17384 316 HSsvyGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINI 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
213-390 |
9.06e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.03 E-value: 9.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 213 IVTLFVSSFILQFAYYSVEPIITiyigQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGI 292
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLP----DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 293 VFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVF 372
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
|
170
....*....|....*...
gi 736016517 373 FITSSLLFFNAIWVYRGV 390
Cdd:cd17324 157 LAIAVLALLAALLLWRLL 174
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-187 |
2.30e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 2.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 7 NLIVCWFGTFVTLIGMSQIAPIMPLYIKQlgIHNVSAISqiSGIAFGATFVVSAIFSPIWGYVADRFGR--KPMLLRASL 84
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVE--VRGLSLAQ--AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....
gi 736016517 164 KFTFFLTGGLMLIAFFTTLFFVKE 187
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRE 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
214-390 |
3.07e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.52 E-value: 3.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 214 VTLFVSSFILQFAYYSVePIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIV 293
Cdd:COG2223 5 RVLLLATLAFFLAFGVW-YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 294 FIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFF 373
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170
....*....|....*..
gi 736016517 374 ITSSLLFFNAIWVYRGV 390
Cdd:COG2223 164 ILGILLLVVAVLAWLFL 180
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
4-182 |
7.94e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 63.34 E-value: 7.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 4 WKRNLIVCWFGTFVTLIGMSQIAPI--MPLYI-KQLGIHnvsaiSQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLL 80
Cdd:cd17471 195 APVNRRLLLLFAAFTLLFAANSMYIiaMPLYVtNELGGS-----ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 81 RASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEF 160
Cdd:cd17471 270 AGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQY 349
|
170 180
....*....|....*....|..
gi 736016517 161 LGLKFTFFLTGGLMLIAFFTTL 182
Cdd:cd17471 350 FGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
216-390 |
1.01e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.60 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIgQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYV-REFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPsINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFIT 375
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170
....*....|....*
gi 736016517 376 SSLLFFNAIWVYRGV 390
Cdd:cd17330 159 AALALLNLVLVLFFL 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
12-178 |
1.80e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.18 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLY-IKQLGIHNVSAIsqisgIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVV 90
Cdd:cd17370 204 LYLLAVALFALGNFSFAFLILrAQELGLSAALIP-----LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITGYS-TACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFL 169
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
....*....
gi 736016517 170 TGGLMLIAF 178
Cdd:cd17370 359 SAVLALIAL 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
2-184 |
1.81e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.21 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 2 KIWKRNLIVCwFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVSAIFspiwGYVADRFGRKPMLLR 81
Cdd:cd17473 194 LPWKRVLPIY-FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLF----GRLKRRLGKRRLLAI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 82 ASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACT-TLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLD-E 159
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLnSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnL 348
|
170 180
....*....|....*....|....*
gi 736016517 160 FLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
49-368 |
1.88e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.93 E-value: 1.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 49 GIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQT 127
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 128 EKKHAGWALGVLSTAFVSG----SLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLfFVKEDFVPSEKKKVESAKE- 202
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRR-FVKEPPQWQAARAARRHFAd 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 203 -------LWKQLPNSNIIVTLFVSSfiLQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAprlGKLSD 275
Cdd:cd17371 196 rpslrelFSPPLLRTTLLASLLATG--ALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAG---GFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 276 RIGPQK-VVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFT 354
Cdd:cd17371 271 RIGRRNnFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGAL 350
|
330
....*....|....
gi 736016517 355 GSVIGGQIAAHLGI 368
Cdd:cd17371 351 FPFLVGFLATSGSL 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
216-407 |
2.11e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.81 E-value: 2.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIyigqLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSL----RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLgikYVFFIT 375
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG---ALPFLI 153
|
170 180 190
....*....|....*....|....*....|....*
gi 736016517 376 SSLLFFNAIWV---YRGVYKKLKDHDKISEADIAM 407
Cdd:cd17477 154 AAVLLLLALVPlllTRRAAPEIEEAESISLRRLLR 188
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
51-354 |
3.16e-10 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 61.62 E-value: 3.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 51 AFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNvYQLIGL---------RILQGVITG--YSTAC 119
Cdd:cd17368 45 TFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPT-YATIGIaapllvllaRLLQGFAAGgeVGGVT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 120 TTLVATQTEKK---HAGWALGVLSTAFVSGSLLGPLVGGYLDEFL----GLKFTFFLtgGLMLIAFFTTL-FFVKEDFVP 191
Cdd:cd17368 124 AYLVEAAPPGRrgfYTSWQSASQQVAIVAGALVGYLLSLTLTAEAlaewGWRIPFFI--GLLIIPLGLWLrRSLEETEAF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 192 SEKKKVESAKELWKQLPNSNIIVTLfvsSFILQFAYYSVEPIITIYIGQLAGSLNHVAL-IAGMAFSASGLANIIAAPRL 270
Cdd:cd17368 202 LERKARPTRRELFALLANNRRIILL---GMLLVAGSTVTFYFTTVYTPTYAKTVLGLSArDSFLVTLLAGVANFIWAPLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 271 GKLSDRIGPQKVVLGALILAGIVFIP--QAFVKNP--WQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFG--FN 344
Cdd:cd17368 279 GALSDRIGRRPVLLVITLAALVTLYPvfAWLTAAPsfGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSlvYA 358
|
330
....*....|
gi 736016517 345 ISAYYMGTFT 354
Cdd:cd17368 359 LAVAIFGGFA 368
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
63-187 |
3.25e-10 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 61.52 E-value: 3.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 63 SPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTA 142
Cdd:cd17389 81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 736016517 143 FVSGSLLGPLVGGYLDEF-LGLKFTFFLT-----GGLMLIAFFTTLFFVKE 187
Cdd:cd17389 161 FSLGFIIGPMIGAYFASFtRSLGEVFFSMpalfaLVLALADLLFIFFFLPE 211
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
16-384 |
3.61e-10 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 61.08 E-value: 3.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKQLGihnvsAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL---GMAVVVGS 92
Cdd:cd17385 9 FSSMICYSILAPFFPREAEKKG-----VSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFvsgGCTILFGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 93 MGLAQNVYQLIGL----RILQGV-ITGYSTACTTLVAtQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTF 167
Cdd:cd17385 84 LDRVPDGTVFIALcflvRIVEAVgFAAFITASFAIIA-KEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 168 FLTGGLMLIAFFTTLF-FVKEDFVPSEKKkvesaKELWKQLPNSNIIVTLFvSSFILQFAYYSVEPIITIYIGQlagsLN 246
Cdd:cd17385 163 LVLGCLLLLTVPLNMFiLPRYDDDPSPKS-----GSMLKLLKIPSVLLLCL-SIVSGSVSLGFLDPTLSPHLRQ----FK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 247 HVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVL---GALILAGIVFI-PQAFVKNPWQLMALRFGLGIATAGLSP 322
Cdd:cd17385 233 LSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMvigSIITGVGFLLLgPAPLLPIKSELWMVIIGLVLLGLSLGA 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 323 S--------INTLLKKITPEKFT--GRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAI 384
Cdd:cd17385 313 AlvptfpelLNCAREYGFPDNLStyGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGI 384
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
252-374 |
4.61e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 60.83 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKI 331
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 736016517 332 TPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
21-372 |
7.67e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 59.95 E-value: 7.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 21 GMSQIAPIMPLYIKQLGIhNVSAISQISGIAFgatfVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVY 100
Cdd:pfam12832 14 ALGCLLPYWGLYLRSIGL-NPSEIGLITAILP----LTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFIPIS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 101 QLIGLRILQGVITGYSTACT-------TLVATQTEKKHAG----W-ALGVLSTAFVSGSLLGPLVGGYLDEFLglkftFF 168
Cdd:pfam12832 89 LTFWWLALLVVLFSFFWNAIlpqfevaTLQHLGEKRKDYGrqrlWgSVGFALSVFGLGALFDHYSVGLLPSVL-----FY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 169 LTGGLMLIAFfttlFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVtLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhv 248
Cdd:pfam12832 164 LFAALMLLSL----LLPLAPPEMEYESKGGSKAVFWNLLKQPEVII-FFLAAFLLGFSHGPFYTFLFLYLENLGAS---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 249 ALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVF-IPQAFVKNPWQLMALRFGLGIATAGLSPSINTL 327
Cdd:pfam12832 235 NTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWlLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEY 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 736016517 328 LKKITPEKFTGRIFGFNISAYY-MGTFTGSVIGGQIAAHLGIKYVF 372
Cdd:pfam12832 315 VRRIFPGSLQGTGQALYSGLYFgLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-185 |
7.68e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 7.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 3 IWKRNLIVCwFGTFVTLIGMSQIAPIMPLYIKQLGIHNVsaisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRA 82
Cdd:cd17489 192 VEKKVLPPA-LILFLASIAYGAISTFLPLYAAERGISNA-------GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 83 SLGMAVVVGSMGLAQNVYQLIGLRILQGVitGYST---ACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDE 159
Cdd:cd17489 264 LLLLALGLLLLSFAGSPWMLLLAAVLYGL--GFGLlfpALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
170 180
....*....|....*....|....*.
gi 736016517 160 FLGLKFTFFLTGGLMLIAFFTTLFFV 185
Cdd:cd17489 342 LFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
255-374 |
1.25e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 255 AFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPE 334
Cdd:cd17321 36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPG 115
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 736016517 335 KFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17321 116 ERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
8-395 |
2.21e-09 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 58.76 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLgihNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFG--RKPMLlrASLG 85
Cdd:cd17326 1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKI---DPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLI--VSIL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 86 MAVV------VGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL-- 157
Cdd:cd17326 76 IAIVgnilyaLAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFtp 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 158 ------DEFLGLKFTFFLTGGLM-----LIAFFTTLFFVKEdfvpsekkkvesakelwkqlpnsniiVTLFVSSFILQFA 226
Cdd:cd17326 156 igypgyVIGIKLRFNMYTAPAWLmailgIINIILILFFFKE--------------------------VVCIFLFFVVLFI 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 227 YYSVEPIITIYIGQLAGSLNHVA-LIAGMAFSASGLANI-----IAAPRLGKLSDRigpqKVVLGALILAGIVFIpqafV 300
Cdd:cd17326 210 FANLETIGTPLTMDMYGWTREEAvLYNGIILAVSGVLSVlvfllFKFLSLGLIDER----KILLGGLILFFLGFV----V 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 301 KNPWQL-MALRFGLGIATAGLspSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLL 379
Cdd:cd17326 282 TLPWGItGVILFGLGYPIGNV--MLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLL 359
|
410
....*....|....*.
gi 736016517 380 FFNAIWVYrGVYKKLK 395
Cdd:cd17326 360 LLAIILLI-VFYKRLV 374
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
67-413 |
4.19e-09 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 58.22 E-value: 4.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 67 GYVADRFGRKPMLLRASLGMAVVvgSMGLA-------QNVYQLIGLRILQGVITGYST-ACTTLVATQTEKKHAGWALGV 138
Cdd:pfam05977 66 GALADNFDRRKIMLAGQLLLALV--STLLTllaglglLSPWLLLGLTFLGGIGTALMDpAWQASVPELVPRRDLPAAVAL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 139 LSTAFVSGSLLGPLVGGYLDEFLGLKFTFfltgGLMLIAFFTTLFF-------VKEDFVPSEKKkVESAKELWKQLPNSN 211
Cdd:pfam05977 144 NSVGYNIARSVGPALGGVLLAAFGPAFTF----ALNALSYFAVIAAlwrwkraAPASPLPRERI-FGAVRAGLRFTAMSR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 212 IIVTLFVSSFILQFAYYSVEPIITIYI-GQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILA 290
Cdd:pfam05977 219 ELRSVLVRAFAFGLSASAVWALLPLVArDLLDGD----AIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVT 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 291 GIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKY 370
Cdd:pfam05977 295 ALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTG 374
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 736016517 371 VFFITSSLLFFNAIWVYRGVYKKLKDHDKIS-----EADIAMDVDTDR 413
Cdd:pfam05977 375 ALLGAAAALLAGAAAGLRFRLPEGEAADLIPsnhwpEPLVALAVKPRR 422
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
216-387 |
6.72e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 57.24 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGAS----PTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRFGLGIATAGLSPSiNTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAA-HLGIKYVFFI 374
Cdd:cd17390 77 LLGFSTSLALLFLSRIPLGIFKHTQSLC-KAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALL 155
|
170
....*....|...
gi 736016517 375 TSSLLFFNAIWVY 387
Cdd:cd17390 156 CSAIFILNAGLVW 168
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
5-385 |
6.88e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 57.25 E-value: 6.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAiSQISGIAFGATFVVSAIFspiwGYVADRFGRKPMLLRASL 84
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEG-AFLATAAFIGRPFGGALF----GLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHagwaLGVLSTAF-VSGSLLGPLVGGYL----DE 159
Cdd:PRK12307 92 AYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKH----LKSKASAFlVSGFGIGNIIAAYFmpsfAE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 160 FLGLKFTFF--LTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIV------TLFVSSFILQFAYYSVE 231
Cdd:PRK12307 168 AYGWRAAFFvgLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLfnraqfPLTLCVFIVLFSIFGAN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 232 -PIITIYIGQLAGSLNHVALIAGMaFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAF--VKNPWQLMA 308
Cdd:PRK12307 248 wPIFGLLPTYLAGEGFDTGVVSNL-MTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRipQDNYLLLGA 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 309 LRFGLGIATAGlspsINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYvfFITSSLLFFNAIW 385
Cdd:PRK12307 327 CLFGLMATNVG----VGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITM--GLGAALTFIVAFW 397
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
16-341 |
7.00e-09 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 57.29 E-value: 7.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKqlgIHNVSAISQISGiafgatFVVSAIFSPIWGYVADRFGRKPMLLRASLG------MAVV 89
Cdd:cd17386 9 FLYMFASVLSGPVTQNFVY---AANFYLYMNLMG------SIPPLFSSLFLGSWSDRYGRKPPLLMSLVGlllsslILVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 90 VGSMGLAQNVYQLIGLRILQGVITGYST---ACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd17386 80 IVYFTTVPSVWWFYLSAIPLALFGGFTAflsASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGGLMLIAFFTTLFFVKedfvpsekkkvesakelwkqlpnsniIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLN 246
Cdd:cd17386 160 FSISAALLLIALLYILFFLT--------------------------LLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWN 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 247 HVALIAGMAFSAsgLANIIAAPRLGKLSDRIGPQKVVLgaLILAGIVFIP-----QAFVKNPWqLMALRFGLGIATAGLS 321
Cdd:cd17386 214 VKDFSYFSTLGS--LIYLTGMLGGVLLLRCLLKMSDST--LAMLGLASHIlssllFAFATNTW-MMYLAAVVGMFNGIVG 288
|
330 340
....*....|....*....|
gi 736016517 322 PSINTLLKKITPEKFTGRIF 341
Cdd:cd17386 289 PMIRSILSKLVPKSEQGKIF 308
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
65-295 |
7.54e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 57.01 E-value: 7.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 65 IWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVitgysTACTTLVATQT------EKKHAGWALGV 138
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF-----GASAGSVISQAlvrdiyPGEELSRIYSI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 139 LSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEK----KKVESAKELWKQLpnsNIIV 214
Cdd:TIGR00710 134 LMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARiqisTYFETFLLLLKSK---MFWG 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 215 TLFVSSFILQ--FAYYSVEPIitIYIGQlagslNHVA-LIAGMAFSASGLANIIAAPRLGKLSDRIG-PQKVVLGALILA 290
Cdd:TIGR00710 211 YALIYGASFGgfFAFFSGAPF--VYIDI-----MGVSpSVFGLLFALNIIAMIFGGFLNGRFIKKWGaKSLLRMGLILFA 283
|
....*
gi 736016517 291 GIVFI 295
Cdd:TIGR00710 284 VSAVL 288
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
271-387 |
9.06e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 9.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 271 GKLSDRIGPQKVVLGALILAGI--VFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAY 348
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLatLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110
....*....|....*....|....*....|....*....
gi 736016517 349 YMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFfnaIWVY 387
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL---LWAL 170
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
232-387 |
1.02e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 56.88 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 232 PIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRF 311
Cdd:cd17388 20 PVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRI 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 312 GLGIaTAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGqIAAHLGIKYVFFITSSLLFFNAIWVY 387
Cdd:cd17388 100 IAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEISPRAPFLVAAGLNGLNFLLGL 173
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-184 |
1.18e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 47 ISGIAFGATFVVSAIFSPIWGY-VADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTAC-TTLVA 124
Cdd:cd17474 235 IIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLlTTLVT 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 125 TQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
252-406 |
1.31e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.40 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKI 331
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 332 TPEKFTGRIFGFNiSAYYMGTFTGSVIGGQIAAH---LGIKYVFFITSSLLFFNAIWVYRGVYKKLKDHDKISEADIA 406
Cdd:COG0738 125 GPETAASRLNLLH-AFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA 201
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
39-381 |
1.33e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.41 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 39 HNVSAISQISGIAFGatfvVSAIFSPIWGYVADRFGRKPMLLrasLGMAVVVGSMGL---AQNVYQLIglrILQGVITGY 115
Cdd:cd17352 35 ESTSDIAWIGSLLLG----VSLFSGPLSSALVNRFGCRPVAI---AGGLLAALGLLLssfATSLWQLY---LTYGVLGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 116 STACTTLVA----TQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVkedfvp 191
Cdd:cd17352 105 GLGLIYSPAivivGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 192 sekkkvesakeLWKQLpnsnIIVTLFVSSFILQFAYYsvepIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLG 271
Cdd:cd17352 179 -----------LLKDP----TFVLLALGVSFAMLGFF----VPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 272 KLSDR--IGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITP-EKFTGRiFGFNISAY 348
Cdd:cd17352 240 LLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGlEKLSNA-YGLVLLFQ 318
|
330 340 350
....*....|....*....|....*....|...
gi 736016517 349 YMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFF 381
Cdd:cd17352 319 GLAALVGPPIAGLLRDYTGDYDAAFYFCGACLL 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-147 |
1.47e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 3 IWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQlgIHNVSAisQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRA 82
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE--VLGLSA--SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 83 SLGMAVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGS 147
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
216-373 |
1.71e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.08 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGmafsASGLANIIAAPRLGKLSDRIGPQKVVLGA-LILAGIVF 294
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILG----AYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLAS 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 295 IPQAFVKNPWQLMALRFGLGIAtAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFF 373
Cdd:cd17490 77 LIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL 154
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-184 |
2.36e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 6 RNLIVCWFGTFVTLIGMSQIAPIMPLYIKqlgiHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLG 85
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFK----YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 86 MAVVVGSMGLAQ--NVYQLIGLRILQGVITG-YSTACTTLVA-------TQTEKKHAGWALGVLSTAFVSGSLLGPLVGG 155
Cdd:COG2211 304 AALGLLLLFFLGpgNLWLLLVLAALAGIGLGaILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAG 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 736016517 156 YLDEFLG--------------LKFTFFLTGG-LMLIAFFTTLFF 184
Cdd:COG2211 384 LLLALFGyvagaaqspsaltgIRLLFFLLPAvLLLLAALLLLFY 427
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
51-367 |
2.57e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.46 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 51 AFGATFVVSAIFSpiwGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGY-STACTTLVATQTEK 129
Cdd:TIGR00881 38 SFSIAYGISKFVM---GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 130 KHAGWALGVLSTA-FVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDFV----------PSEKKKVE 198
Cdd:TIGR00881 115 SERGTWVSFWNCShNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQscglppaeemPNEEPDGD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 199 SAKE----------LWKQLPNSNIIVTLFVssfilQFAYYSVEPIIT----IYIGQlagSLNHVALIAGMAFSASGLANI 264
Cdd:TIGR00881 195 AEKKeeeltkkqifLQYVLLNKVLWYISLG-----YVFVYVVRTGILdwspLYLTQ---EKGFSKEKASWAFTLYELGGL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 265 IAAPRLGKLSDRI-----GPQKVVLGALILAG-IVFIPQAFVKNPWQLMALrFGLGIATAGLSPSINTLLKKITPEKFTG 338
Cdd:TIGR00881 267 VGTLLAGWLSDKLfngrrGPLAVFFMALIIVSlLVYWLNPAANPLMDLICL-FALGFLVYGPQMLIGVIASELAPKKAAG 345
|
330 340
....*....|....*....|....*....
gi 736016517 339 RIFGFNISAYYMGTFTGSVIGGQIAAHLG 367
Cdd:TIGR00881 346 TAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-367 |
4.06e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.94 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 49 GIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGviTGYST---ACTTLVAT 125
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG--AGYGSvqpGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 126 QTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGL-MLIAFFTTLFFVKEDFVPSEKKKVESAKELW 204
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVsILAAVLFWLFYREPPAASAATESASTLLRSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 205 KQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGsLNHVAliAGMAFSASGLANIIAAPRLGKLSDRIGPQ---K 281
Cdd:cd17475 192 KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLG-LSVVA--AGALLAVAQLGGALGRIGLGRVSDRVFGGrrrP 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 282 VVLGALILAGIVFIPQAFVK---NPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVI 358
Cdd:cd17475 269 VLVITAAIAAAALLVLSLLSpgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPL 348
|
....*....
gi 736016517 359 GGQIAAHLG 367
Cdd:cd17475 349 FGLLVDATH 357
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
216-387 |
6.82e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.14 E-value: 6.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 216 LFVSSFILQFAYYSVEPIITIYIGQLAGSlnhVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFI 295
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGA---TPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNPWQLMALRF--GLG-IATAGLSpsintLLKKITPEKFTGRIFGFnISAYYMGTFTGSVIGGQ-IAAHLGIKYV 371
Cdd:cd17472 78 LAAYATSIYGLILGRAlqGSGaISSVVMA-----LLADLTREENRTKAMAL-IGASIGIAFAISMVLGPlLAAHLGVSGL 151
|
170
....*....|....*.
gi 736016517 372 FFITSSLLFFNAIWVY 387
Cdd:cd17472 152 FLITAILSLVSLLILL 167
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
6-182 |
7.24e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.09 E-value: 7.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 6 RNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISqisgIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLG 85
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII----GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 86 MAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKF 165
Cdd:cd17324 274 AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
170
....*....|....*..
gi 736016517 166 TFFLTGGLMLIAFFTTL 182
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
212-367 |
9.86e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 9.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 212 IIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAG 291
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLS----ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 292 IVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKfTGRIFGFNISAYYMGTFTGSVIGGQIAAHLG 367
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-182 |
1.57e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQIsGIAFGATFVVSAIFSPIWGYVADR-FGRKPMLLRASLGMAVVV 90
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 91 GSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL-DEFLGLKFTFF 168
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGgLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFL 364
|
170
....*....|....
gi 736016517 169 LTGGLMLIAFFTTL 182
Cdd:cd06174 365 VLAVLLLLAAILLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
244-390 |
1.69e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.60 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 244 SLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPS 323
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 324 INTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKY---VFFITSSLLFFNAIWVYRGV 390
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwrILFLIGALPALLALLLRRRT 179
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
49-322 |
1.69e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.99 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 49 GIAFGATFVVSAIFSPIWGYVADR-----FGRKPMLLRASLGMAVVV-------GSMGLAQNVYQLIGLRILQGVITGYS 116
Cdd:cd17332 38 GTIFLVARIIDAINDPLMGYLIDRtrsrwGRFRPWLLWGAIPLALLFvllfttpDGSGTGKLIYALITYILLDLLYTLVN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 117 TACTTLVATQTEKKH------AGWALGVLSTAFVSGSLLGPLVG--GYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKED 188
Cdd:cd17332 118 IPYTALIPELTDDPEertsltSWRMFFATIGGLLVTVLPPPLVAyfGGGNASRGYFLTALIIGIIGIILLLICFFGTRER 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 189 FVPSEKKKVESA-KELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSlnhvALIAGMAFSASGLANIIAA 267
Cdd:cd17332 198 VVPPEEEKSKLPlLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGG----RAELVLLLLLILSGALLAL 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 268 PRLGKLSDRIGPQKVVLGALILAGIVFIPQAFV--KNPWQLMALRFGLGIATAGLSP 322
Cdd:cd17332 274 LPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLppGNLVLILVLAVLAGIGYGGANL 330
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
29-320 |
2.18e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 52.63 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 29 MPLYIKQLGIHNvsaisQISGIAFGATFVVSAIFSPIWGYVADR----FG-RKPMLLRASLGMAVVVGSMGLAQNV-YQL 102
Cdd:cd17313 22 VPPILQTLGLSH-----ALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIgLAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 103 IGLRILQGVITGYSTACTTLVATQT---------------EKKHAGWALGVLSTAFvsGSLLGPLVGGYL--------DE 159
Cdd:cd17313 97 GDGPRTWALVLFVLGIVLLDFAMNVcqgpvrallpdlvppEQRSKANGIINFMGGL--GGVLGYLLGAILwdhnwfgfAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 160 FLGLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVT--------LFVSSFILQFAYYSVE 231
Cdd:cd17313 175 GGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKimprsllrLLLVIFFWWIAFFPFE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 232 PIITIYIGQL---AGSLNHVALIAGMAFSASGL-----ANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNP 303
Cdd:cd17313 255 LFFTDYMGEEvyhGTSAASSHYGAGVRMGAWGLlifslAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNV 334
|
330
....*....|....*..
gi 736016517 304 WQLMALRFGLGIATAGL 320
Cdd:cd17313 335 TVALVLFALGGIGWATI 351
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
5-185 |
2.43e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.22 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNvSAISQISGIAFGATFVVSAIFSPIWgyvADRFGRKPMLLRASL 84
Cdd:cd17490 194 KKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASS-FQLGLLSIIYLLPNALASLLSGTLF---YKKLGERNTIIIGFL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLAQNVYQLIGLRILQGVITGY-STACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGL 163
Cdd:cd17490 270 LLGAYCFLIPFAPNLTLLYLLQALNGFGTGIlFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGL 349
|
170 180
....*....|....*....|..
gi 736016517 164 KFTFFLTGGLMLIAFFTTLFFV 185
Cdd:cd17490 350 QTGFFVIGVIALLAAILSLAYY 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-179 |
2.98e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 52.33 E-value: 2.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 63 SPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWAlGVLST 141
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFLPKKQRAIV-GTLIQ 222
|
90 100 110
....*....|....*....|....*....|....*....
gi 736016517 142 AFVS-GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFF 179
Cdd:TIGR00898 223 VFFSlGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSW 261
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
9-184 |
4.09e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 51.86 E-value: 4.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 9 IVCWFGTFVTLIGMSQIAPIMPLYIKQLGIhnvsaiSQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLgmAV 88
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGP------SSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNL--LG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 89 VVGSM--GLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL--DEFLGLK 164
Cdd:cd06179 73 VVGSIvaGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWR 152
|
170 180
....*....|....*....|
gi 736016517 165 FTFFLTGGLMLIAFFTTLFF 184
Cdd:cd06179 153 WIFYINAIFNALALILLFFF 172
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
52-309 |
5.84e-07 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 51.14 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 52 FGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAvvVGSMGLA-QNVYQLIGL---------RILQGVITG--YSTAC 119
Cdd:cd17367 46 FAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMA--AGSLVIAvTPTYATIGIwapiilllaRLLQGLSVGgeYGTSA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 120 TTLVATQTeKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFL--------GLKFTFFLTGGLMLIAFF------TTLFFV 185
Cdd:cd17367 124 TYLSEVAP-PGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVVVLWlrrgleETESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 186 KEDfvPSEKKKVESAKELWKQlPNSNIIVTLFVSSFILqfAYYSVEPIITIYIGQLAGSLNHVALIAGMafsASGLANII 265
Cdd:cd17367 203 AIA--ESNEASAGTLRELRRH-PRELLLVVGLTAGGTL--AFYTWTTYLQKFLVNTAGFSKGDATWITT---AALLVFML 274
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 736016517 266 AAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAF----VKNPWQLMAL 309
Cdd:cd17367 275 LQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSaldhTDSPYTAFAL 322
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
12-381 |
6.50e-07 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 51.19 E-value: 6.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 12 WFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVsaifsPIWGYVADRFGRKPMLLRASLGMAVVVG 91
Cdd:cd17396 6 YFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTI-----LFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWAlGVLSTAFVS-GSLLGPLVGGYL-DEFLGLKFTFFL 169
Cdd:cd17396 81 GILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSA-NILVKAFVSfGQFLLPFIIAFLaANNLWYGWSFIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 170 TGGLMLIaffTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVA 249
Cdd:cd17396 160 PAAVLVL---NALLLLKLSFPPQTVTAANTKQKEIPVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 250 LIAGMA----FSASGLANIIAAPRLGKlsDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSIN 325
Cdd:cd17396 237 EAESLKlisyYSMGSLVCVFITAVLLK--RYVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLG 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 326 -TLLKKITPEKfTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFF 381
Cdd:cd17396 315 lTLMAEFFPKG-KGKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-184 |
9.76e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.69 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMsqiapIMPLYIKQLGIHNVSAISQISGiAFGATFVVSAIFSPIWGyvaDRFGRKPMLLRASLGMA 87
Cdd:cd06173 215 LALALFALLGGALTV-----LLPLLAKEVLGGGAAGYGLLLA-AFGVGALLGALLLGRLS---KRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 88 VVVGSMGLAQNVYQLIGLRILQGVITGYS-TACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 736016517 167 FFLTGGLMLIAFFTTLFF 184
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
3-182 |
1.18e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 3 IWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIafgaTFVVSAIFSPIWGYVADRFGRKPMLLRA 82
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL----ISLGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 83 SLGMAVVVGSMGLAQN---VYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGV-LSTAFVSGSLLGPLVGGYLD 158
Cdd:cd17316 250 LILSGILALPLFYLLSgspTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLA 329
|
170 180
....*....|....*....|....
gi 736016517 159 EFLGLKFTFFLTGGLMLIAFFTTL 182
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-187 |
1.31e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 50.30 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 27 PIMPLYIKQLGihnVSAIS-QISGIAFGATFvvsAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGL 105
Cdd:PRK11102 12 PALPVIAADFG---VSAGSvQMTLSAYILGF---AIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 106 RILQG-------VITGystactTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAF 178
Cdd:PRK11102 86 RFLHGlaaaaasVVIN------ALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAA 159
|
....*....
gi 736016517 179 FTTLFFVKE 187
Cdd:PRK11102 160 ALVFFFIPE 168
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-151 |
1.87e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 3 IWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRA 82
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA-----GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736016517 83 SLGMAVVVGSMGLA----QNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGP 151
Cdd:pfam07690 272 LLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
31-183 |
4.26e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.78 E-value: 4.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 31 LYIKQLGIHNVSAISQISGI-----AFGATF--VVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLI 103
Cdd:cd17313 259 DYMGEEVYHGTSAASSHYGAgvrmgAWGLLIfsLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVAL 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 104 GLRILQGVitGYSTACT---TLVA--TQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAF 178
Cdd:cd17313 339 VLFALGGI--GWATINInpyPLVSdyHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSL 416
|
....*
gi 736016517 179 FTTLF 183
Cdd:cd17313 417 VGALF 421
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
265-367 |
5.51e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.39 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 265 IAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFN 344
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVF 128
|
90 100
....*....|....*....|...
gi 736016517 345 ISAYYMGTFTGSVIGGQIAAHLG 367
Cdd:cd17328 129 YFAIPLGSGLGYVVGGLVAQATG 151
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-183 |
5.77e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.95 E-value: 5.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 29 MPLYIKQLGIHNVSAISQISGIAFgatfVVSAIFSPIWGYVADRF---GRKPMLLRASLGMAVVVGSMGLAQNVY-QLIG 104
Cdd:cd17319 202 LPTYLKQARGFSLKQVGLLAAIPF----LAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVvAVIL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 105 LRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL-DEFLGLKFTFFLTGGLMLIAFFTTLF 183
Cdd:cd17319 278 LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLvDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
1-182 |
5.93e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 5.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 1 MKIWKRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLL 80
Cdd:cd17478 190 LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA-----GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVII 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 81 RASLGMAVVVGSMGLAQNVYQLIGLrILQGVITGYSTACTTLVATQTEKKHAGWALG-VLSTAFVSGSLLGPLVGGYLDE 159
Cdd:cd17478 265 ASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGNVGLASGlMMGLSFGLGGIGAPVLGALADA 343
|
170 180
....*....|....*....|...
gi 736016517 160 FlGLKFTFFLTGGLMLIAFFTTL 182
Cdd:cd17478 344 F-GLESVLLILALLPLLGALLAF 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
253-389 |
6.75e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.76 E-value: 6.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 253 GMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKIT 332
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 333 PEKFTGRIFGF-NISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSL-LFFNAIWVYRG 389
Cdd:TIGR00881 113 SRSERGTWVSFwNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIaIIVSLICFLLL 171
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
8-317 |
6.93e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 6.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 8 LIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIhnvsAISQISgiAFGATFVVSAIFSPI-WGYVADRFG-RKPMLLRASLG 85
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGL----STSQIG--LLVAIPVLAGALLRLpYGFLCDRFGgRRVFIASLLLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 86 MAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGS----LLGPLV---GGYLD 158
Cdd:cd17341 75 LIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVavsqLLAPLIagaIVFDG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 159 EFLGLKFTFFLTGGLMLIAFFTTLFFVKeDFVPSEKKKVESAKELWKQLPNSNiivtlfvsSFILQFAY---YSVEPIIT 235
Cdd:cd17341 155 GFVGWRNAFFVPGILLAIAAVLVLLFGD-DLPTGKASALEFLKVQLAVLKNYR--------TWILSLLYgvtFGSFVGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 236 IYIGQLAGSLNHVALIAGMAFSAS-GLANIIAAPRLGKLSDRIGPQKVVLGALILAGI-----VFIPQAFVKNPWQLMAL 309
Cdd:cd17341 226 NVLPTYFKTRFGLPLVTAGILAALfPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIgaallSLSLPTSGTNLVLFLAL 305
|
....*...
gi 736016517 310 RFGLGIAT 317
Cdd:cd17341 306 FVALGLGA 313
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
232-387 |
1.04e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 232 PIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPrlgkLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRF 311
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 312 --GLGIATAgLSPSINTLLkKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVY 387
Cdd:cd17323 96 lqGFFGSSP-LAIGAGTIA-DLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIF 171
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
215-400 |
1.11e-05 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 47.18 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 215 TLFVSSFILQFAYYSVEPIITIYIGQLAG---SLNHVALIAGmAFSASG-LANIIAaprlGKLSDRI-GPQK-VVLGALI 288
Cdd:cd17346 6 TLFFTEMWERFSYYGMRAILILYLTAQLGdgfSEADAASIYG-AYTALVyLTPIIG----GWLADKVlGARRtVFIGGIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 289 LAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNIsaYYM----GTFTGSVIGGQIAA 364
Cdd:cd17346 81 MALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSI--FYMginlGAFLAPLLCGTLGD 158
|
170 180 190
....*....|....*....|....*....|....*.
gi 736016517 365 HLGIKYVFFITSSLLFFNAIWvYRGVYKKLKDHDKI 400
Cdd:cd17346 159 NYGYHYGFGLAAVGMLLGLLI-FLLGRKKLLERKKM 193
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
32-384 |
1.20e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 47.11 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 32 YIKQLGihnvSAISQISGI--AFGATFVVSAIFSpiwGYVADRFG-RKPMLLRASLGMAVVVG--SMGLAQNVYQLI--- 103
Cdd:cd17337 23 YLVDLG----FSEAQAALLftVYGLTVAIASWLS---GVLAELFGpRRVMLIGLIIWLVFEVLflAFGLPSHNYPLMllt 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 104 -GLRILqgvitGY---STACTTLVATQTEKKHAGWALGVLSTAFVSG-SLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAF 178
Cdd:cd17337 96 yGLRGF-----GYplfAYSFLVWITYRTPAERLGSAVGWFWFAFTGGlPVLGSYLASFTIPVIGEIGTLWLSLVFVALGG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 179 FTTLFFVKEDfvPSEKKKVESAKELWKQLP--------NSNIIVTLFVSSF--ILQFAYYSVEPIItiYIGQLAGSLNHV 248
Cdd:cd17337 171 LIALFLVRDR--TGEQPLANPSEEPLKELLsgitilfrNPKIAIGGIVRIIntLSQFGFPVFMPLY--FTDTGGFSTSQW 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 249 ALIAGMAFsasgLANIIAAPRLGKLSDRIGPQKV------VLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSP 322
Cdd:cd17337 247 LQIWGIIF----LVNIFFNLIFGILGDKIGWRRTvrwfggVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAGFVP 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 323 sINTLLKKITPEKftgriFGFNISAYYMG----TFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAI 384
Cdd:cd17337 323 -LSALMPSLAPEH-----KGAAMSILNLGaglsNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAV 382
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-184 |
1.29e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.22 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 32 YIKQLGIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILqGV 111
Cdd:cd17353 235 QAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVA-LI 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736016517 112 ITGYSTACTTLVATQTEK---KHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:cd17353 314 GFCYGGGFALFPALTADFfgtKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
56-327 |
1.36e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.80 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 56 FVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGW 134
Cdd:cd17317 35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVtSAGIFTVGFVLGMEIVGPKYRSF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 135 ALGVLSTAFVSGSLLGPLVGGYLDEFLGLkftffltggLMLIAFFTTLFFVkedfvpsekkkvesakeLWKQLPNSNIIV 214
Cdd:cd17317 115 VGILFGLFWALGYMLLALLAYLIRDWRWL---------QLAISLPGLLFLL-----------------LLWWLPRRTIIV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 215 TL--FVSSFIlqfaYYSvepiITIYIGQLAGSLNhvaliagMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGI 292
Cdd:cd17317 169 GLiwFVTSLV----YYG----LSLNSSNLGGNLY-------LNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGL 233
|
250 260 270
....*....|....*....|....*....|....*
gi 736016517 293 VFIPQAFVKNPWQLMALRFGLgIATAGLSPSINTL 327
Cdd:cd17317 234 ACLVTALLPDDENTLALTLAL-VGKFAISAAFSVI 267
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
261-387 |
1.67e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.86 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 261 LANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKItpekFTGRI 340
Cdd:cd17327 52 VGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW----YKREE 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 341 FGFNISAYYMGTFTGSVIGGQIAAHL----------GIKYVFFITSSLLFFNAIWVY 387
Cdd:cd17327 128 QAKRIAFFYAAAGLGSIFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIF 184
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
271-387 |
1.81e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.46 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 271 GKLSDRIGPQKVVLGALILAGI--VFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAY 348
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALltLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGS 156
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 736016517 349 YMGTFTGSVIGGQIAAHLGIKYVFFITSSL-LFFNAIWVY 387
Cdd:cd17318 157 QFGTVIAMPLSGFLCESLGWPSIFYIFGGLgLLWCLLWFF 196
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
65-234 |
1.86e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 46.42 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 65 IWGYVADRFGRKPMLLrasLGMAV-VVGSMGLA--QNVYQLIGLRILQGVitGYSTACTTLVATQTEKKHAGWALGVLST 141
Cdd:PRK11043 60 LWGPLSDRYGRKPVLL---AGLSLfALGSLGMLwvESAAQLLVLRFVQAV--GVCSAAVIWQALVIDRYPAQKANRVFAT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 142 --AFVSGS-LLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEdfvpSEKKKVESAKELWKQLPNSNII---VT 215
Cdd:PRK11043 135 imPLVALSpALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPS----KKARKQSQDALTFKQLLKSKTYlgnVL 210
|
170
....*....|....*....
gi 736016517 216 LFVSSFILQFAYYSVEPII 234
Cdd:PRK11043 211 IFAACSAAFFAWLTGSPFI 229
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
65-377 |
2.35e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 65 IWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTA-CTTLVATQTEKKHAGWALGVLSTAF 143
Cdd:cd17312 57 ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPpCVKLLGNWFSKKERGTVYGIWSTSH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 144 VSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDfvpsekkkvesakelwkqlpNSNIIVTLFVSSFIl 223
Cdd:cd17312 137 NFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS--------------------PPYVWVLSLAYAFV- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 224 QFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAprlGKLSDRIGPQKVVLGALI--------LAGIVFI 295
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILA---GLLSDKLFGGRRAPIAVIymllmtlsLALFWFF 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 296 PQAFVKNpwqlMALRFGLGIATAGLSPSINTL-LKKITPEKFTGRIFGF-NISAYYMGTFTGSVIGGqIAAHLGIKYVFF 373
Cdd:cd17312 273 PHNKLLS----IVLLFLIGFFVGGPINLIGGAaAQDIGRKEAAGTATGFvGLFGYLGASLAGLPLGY-IIDHYGWSTVFY 347
|
....
gi 736016517 374 ITSS 377
Cdd:cd17312 348 FLIS 351
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
67-176 |
2.35e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 46.19 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 67 GYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVIT-GYSTACTTLVATQTEKKHAGWALGVLSTAFVS 145
Cdd:cd17379 54 GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGkGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTL 133
|
90 100 110
....*....|....*....|....*....|.
gi 736016517 146 GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLI 176
Cdd:cd17379 134 GLLILPGIAYFIPHWRWLQLAVTLPNFLFLL 164
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
60-386 |
2.67e-05 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 45.95 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 60 AIFSPIWGYVADRFGRkpMLLRAS----LGMAVVVGSMGLA-QNVYQLIGLRILQGVI----------TGYSTACTT--- 121
Cdd:cd06176 49 APLRVWIGHRSDTHPL--RGYRRTpyiwLGMLLLALGLALApFAALLLAGAAFWLGLAlavlafllygIGVGAAGTAfla 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 122 LVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGG-YLDEFLGLKFtFFLTGGLMLIAFFTTLFFV-------KEDFVPSE 193
Cdd:cd06176 127 LLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGrLLDPYSPERL-IQVFQIVALVALLLALLALwgverrrSRAALAAE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 194 KKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAG-------SLNhvALIAGMAFSASGLANIIA 266
Cdd:cd06176 206 EAPPETFREALRLLWASPQARRFFIFLFLSTLALFMQDVILEPFGGEVFGmsvgettRLT--AIWGGGTLLGMLLAGFLL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 267 APRLGK-LSDRIGpqkVVLGALILAGIVFipQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNI 345
Cdd:cd06176 284 SRRLGKkRTAALG---CLLSALGFLLLAL--AGLLGNPWLFRPGVFLLGLGNGLFTVGALTLMMDLTGEGTAGLFMGLWG 358
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 736016517 346 SAYYMGTFTGSVIGGQI---------AAHLGIKYVFFItSSLLFFNAIWV 386
Cdd:cd06176 359 AAQALARGLGTLLGGALrdllralfgSPALAYGLVFLL-EAVLLLVALLL 407
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
43-403 |
2.86e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.11 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 43 AISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLA---QNVYQLIGLRILQGVITGYSTAC 119
Cdd:pfam00083 43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 120 TTLVATQTEKKHAGWALGVLSTAFVS-GSLLGPLVG---GYLDEFLGLKFTFFLTGGLMLIAFFTTLFF----------- 184
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITfGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIGLLFLpesprwlvekg 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 185 -----------------VKEDFVP-------SEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQ 240
Cdd:pfam00083 203 rleearevlaklrgvpdVDRELDEikdsleaGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 241 LAGSLNHVALIAGMAFSASgLANIIAAPrlgkLSDRIGPQKVVL----GALILAGIVFIPQAFVKNPWQLMALRFGLGIA 316
Cdd:pfam00083 283 NLGLSDSFLVTIIVGVVNF-VFTFIAIF----LVDRFGRRPLLLlgaaGMAICFVILGIVALLGVSKSDWAGIVAIVFIA 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 317 --TAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGG----QIAAHLGIKYVFFITSSLLFFNAIWVYRGV 390
Cdd:pfam00083 358 lfIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGflfpIITDAIGLGYTFFIFAGLLVLFIIFVFFFV 437
|
410
....*....|....
gi 736016517 391 YK-KLKDHDKISEA 403
Cdd:pfam00083 438 PEtKGRTLEEIDEL 451
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
253-374 |
4.42e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 45.34 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 253 GMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKIT 332
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAV 132
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 736016517 333 PEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
14-187 |
6.14e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.87 E-value: 6.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 14 GTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIA----FGAtfVVSAIFSpiwGYVADRFGRKPMLLRASLGMAVV 89
Cdd:cd17358 10 GSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGslltLGA--LIGALLS---GKLADRIGRKRTLLISAIPCILG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 90 VGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGwALGVLSTAFV-SGSLLGPLVGGYLDeflglKFTF 167
Cdd:cd17358 85 WLLIAFAKDVWMLYLGRFLAGFGGGaASVVVPVYIAEIAPKNVRG-ALGSLNQLLVnIGILLGYVLGSFLP-----WRTL 158
|
170 180
....*....|....*....|
gi 736016517 168 FLTGGLMLIAFFTTLFFVKE 187
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPE 178
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
25-156 |
6.49e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.87 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVSAIFSpiwGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIG 104
Cdd:cd17315 16 INGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFG---GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIV 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 736016517 105 LRILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGY 156
Cdd:cd17315 93 GRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGL 144
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
270-376 |
7.30e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 44.68 E-value: 7.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 270 LGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYY 349
Cdd:TIGR00710 60 WGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLA 139
|
90 100
....*....|....*....|....*..
gi 736016517 350 MGTFTGSVIGGQIAAHLGIKYVFFITS 376
Cdd:TIGR00710 140 LAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
16-385 |
8.10e-05 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 44.61 E-value: 8.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKQLGIhnvsAISQIsGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMgl 95
Cdd:cd17479 6 FFHSAGKACLLPFLTLYFRQLGL----TAPQV-GIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 96 aqnVYQLIGLRILQGVITGYSTACTTLVA-------------TQTEKKHAGWALgvlsTAFVSGSLLGPLVGGYLDEFLG 162
Cdd:cd17479 79 ---YHQIFLLVLLVIIIWELLSAPLEKVAddslyeyldfvdaTERYGKLKVWSA----LGAAFGPCGITLLVDNLDCFLP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 163 LK-----FTFFLTGGLMLIAFFTTLFFvkEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIY 237
Cdd:cd17479 152 PKisrilLHFYTYGGFMILTFLLSFFY--PIPVPKKEEHSSKVVKGLRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 238 IGQLAGSlnhvALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIAT 317
Cdd:cd17479 230 MQDKGGS----ELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSN 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 318 AGLSPSINTLLKKI-TPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLffnAIW 385
Cdd:cd17479 306 GALWWAVNSQVEFLaSPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVL---GLW 371
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-185 |
9.72e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.15 E-value: 9.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 45 SQISGIAFGATF---VVSAIFSpiwGYVADRFGRKPMLLRASLGMAVVVGSMGLAQN--VYQLIGLRILQGVITGYS-TA 118
Cdd:cd17318 55 EKTQGIILSSFFygyILTQIPG---GYLAEKYGAKRVLGYSILITALLTLLTPLAARggYGALIVLRILQGLAQGVTfPA 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736016517 119 CTTLVATqtekkhagWA----LGVLSTAFVSGSLLGPLV----GGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFV 185
Cdd:cd17318 132 MHALWAK--------WAppleRSRLTSIAYSGSQFGTVIamplSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
28-179 |
1.22e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.14 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 28 IMPLYIKQLGIhNVSAISQISGIaFGAtfVVSAIFSPIWGYVADRFGRKPMLLR------ASLGMAVVVGSMGLAQNVYQ 101
Cdd:cd17485 229 MLPPFLVDRGF-SLSQIGLLSGV-GGS--LVSIAGSLLGGYLLKRRGRRRLLLLggllrlLLLGLYTLLALGGSGLNWVL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 102 LIGLRILQGVITGYSTACT-TLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFF 179
Cdd:cd17485 305 LLASLALLHLVGGMITTALfTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVL 383
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
67-187 |
1.33e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 44.05 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 67 GYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVS 145
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTsICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 736016517 146 GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKE 187
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPE 193
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
16-184 |
1.84e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 43.36 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 16 FVTLIGMSQIAPIMPLYIKQLGIHNVSAisqisGIAFGATFVVSAIFSPIWGYVADRFG-RKPMLLRASLGMAV---VVG 91
Cdd:cd17385 211 VSGSVSLGFLDPTLSPHLRQFKLSPGQV-----GLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVgflLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 92 SMGLAQNVYQL----IGLrILQGVITGYSTACTTLVATQTEKKHA--------GWALGVLSTAFVSGSLLGPLVGGYLDE 159
Cdd:cd17385 286 PAPLLPIKSELwmviIGL-VLLGLSLGAALVPTFPELLNCAREYGfpdnlstyGLVSGLFNAAFSLGAFIGPTLGGFLLE 364
|
170 180
....*....|....*....|....*.
gi 736016517 160 FLGLKFTFFLTGGL-MLIAFFTTLFF 184
Cdd:cd17385 365 RLGFEWAATIQAGLaFVVGILMSIYY 390
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
146-384 |
1.95e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 43.33 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 146 GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFvkedfvpseKKKVESAKELWkqlpnsnIIVTLFVSSFILQF 225
Cdd:cd17346 145 GAFLAPLLCGTLGDNYGYHYGFGLAAVGMLLGLLIFLLG---------RKKLLERKKML-------AIIILFLFAVVFWA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 226 AYYSVEPIITIYIGQLAGSLNHVALIAGMAF-SASGLANIIAAPRLG----KLSDRIG----PQKVVLGALILA------ 290
Cdd:cd17346 209 IYEQAGTSLALFADENVDRLLGGFTIPPSWFqSLNPLFIILLAPILAalwtKLGKRGKdpsiPTKFALGLLLLGlsfllm 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 291 --GIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFnisaYYMGTFTGSVIGGQIAAHLGI 368
Cdd:cd17346 289 vlAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGL----WFLASALGNILAGYLAGFYAQ 364
|
250
....*....|....*...
gi 736016517 369 KYV--FFITSSLLFFNAI 384
Cdd:cd17346 365 PKDplASALVYTDYFGLI 382
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
65-196 |
1.96e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 43.36 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 65 IWGYVADRFGRKPMLLrasLGMAV-VVGSMG--LAQNVYQLIGLRILQGVITGYSTActtLVATQTEKKHAGWAL----G 137
Cdd:PRK11652 62 FYGPLSDRVGRRPVIL---VGMSIfILGTLValFAHSLTVLIAASAIQGLGTGVGGV---MARTLPRDLYEGTQLrhanS 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 138 VLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDfVPSEKKK 196
Cdd:PRK11652 136 LLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET-RPADARR 193
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
44-188 |
2.03e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.22 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 44 ISQISGIAFG-ATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQG-VITGYSTACTT 121
Cdd:COG2270 271 FSTTELIVFGlLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGlVMGGIQALSRS 350
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 122 LVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKED 188
Cdd:COG2270 351 LLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVP 417
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
45-184 |
2.10e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 43.44 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 45 SQISGIAFGATFVVsAIFSPIWGYVADRFGRKPMLLRASLG----MAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACT 120
Cdd:cd17367 259 GDATWITTAALLVF-MLLQPLGGRLSDRIGRRPLLLFFGIGgtlaTVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSIN 337
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736016517 121 TLVATQTEKKHAGwALGV-----LSTAFVSGSllGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFF 184
Cdd:cd17367 338 AVVKAELFPTHVR-ALGVglpyaLAVAIFGGT--APYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRM 403
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
251-353 |
2.13e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 251 IAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKK 330
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100
....*....|....*....|...
gi 736016517 331 ITPEKFTGRIFGFNISAYYMGTF 353
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYM 128
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
53-197 |
2.41e-04 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 43.26 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 53 GATFVVSAIFSPIWGYVADRFGRKPMLLRASLGM----AVVVGSMGLAQNV-YQLIGlRILQGVITGYST---ACTTLVA 124
Cdd:cd17449 72 LGGFLVGLFSVTLLGPWSDSVGRRPVLILPSLGLalqaAVYLLVMYLQLHVaYFLIG-RILSGLLGDFNGilaGCFAYVA 150
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736016517 125 TQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKV 197
Cdd:cd17449 151 DVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARL 223
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
9-306 |
2.56e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.02 E-value: 2.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 9 IVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNvsaiSQISGIAfGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAV 88
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSP----NQLSWLA-ASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 89 VVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEK-KHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFT 166
Cdd:cd17476 76 WSLIAGFSPNFIFFIICRALQGLgPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 167 FFLTGGLMLIAFFTTLFFVKEDFVPSEkkkvesakelwkqlpnsnIIVTLFVSSFIlqfayysvepIITIYIGQLAGSLN 246
Cdd:cd17476 156 FWFLAILAAIVAVAAIFWTSPSFIAVL------------------LAVFLGWASFG----------IWVFYATQYFQNVR 207
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736016517 247 HV-ALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALI--LAGIVFIPQAFVKNP-WQL 306
Cdd:cd17476 208 GYsPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVafLVGPILFATMPVHQTyWAQ 271
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
251-402 |
4.38e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 42.42 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 251 IAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIV--FIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLL 328
Cdd:TIGR00894 77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVIsiVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 329 KKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFfnAIW---VYRGVYKKLKDHDKISE 402
Cdd:TIGR00894 157 VKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVG--CAWsllWFVFPADDPSIHPCISK 231
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
5-320 |
4.55e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 42.00 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGAtfVVSAifsPIWGYVADRFGRKPMLLraSL 84
Cdd:PRK10091 2 KKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGV--VVGA---PIIALFSSRYSLKHILL--FL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSM--GLAQNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAG-WALGVLSTAFVSGSLLGPLVGGYLDEFL 161
Cdd:PRK10091 75 VALCVIGNAmfTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVtAAVAGMVSGMTVANLLGIPLGTYLSQEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 162 GLKFTFFLTGGLMLIAFFTTLFFVKEDFVPSEKKKVESAKELWKQLPNSNIIVTLFVSSFIlqFAYYS-VEPIITIYIGQ 240
Cdd:PRK10091 155 SWRYTFLLIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGV--FAWFSyIKPYMMFISGF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 241 LAGSLNHVALIAGMAFSasgLANIIAaprlGKLSDRIGPQKVVLGA-LILAGIVFIPQAFVKNPWQLMALRFglgIATAG 319
Cdd:PRK10091 233 SETSMTFIMMLVGLGMV---LGNLLS----GRLSGRYSPLRIAAVTdFIIVLALLMLFFFGGMKTASLIFAF---ICCAG 302
|
.
gi 736016517 320 L 320
Cdd:PRK10091 303 L 303
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
31-146 |
5.34e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.87 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 31 LYIK-QLGIHNVSAISQ--ISGIAFGATFVvSAIFSpiwGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRI 107
Cdd:cd17360 21 LYIKdDLGEVVLSTGWQelIVSSTVAGAAV-GAAIG---GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRV 96
|
90 100 110
....*....|....*....|....*....|....*....
gi 736016517 108 LQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSG 146
Cdd:cd17360 97 LVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITG 135
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
233-390 |
6.57e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 233 IITIYIGQLA--GSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIP-QAFVK-NPWQLMA 308
Cdd:COG2270 33 VFPPYFTSVAalGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAaLFFVApGGLWLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 309 LRFGLGIATAGLS-PSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIG----------GQIAAHLGIKYVFFITSS 377
Cdd:COG2270 113 LLFVLANIGFEGSlVFYNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINlalflkpeafGLPDAGEAVRISFLLTAL 192
|
170
....*....|...
gi 736016517 378 LLFFNAIWVYRGV 390
Cdd:COG2270 193 WWLLFALPLFLFL 205
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
261-381 |
7.33e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 41.44 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 261 LANIIAAP---RLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFT 337
Cdd:cd17482 232 LTQFVAFPgalLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLVQGGIQALSRSLFGRLIPKGKS 311
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 736016517 338 GRIFGF-NISAYYMGTFTGSVIGgqIAAHLGIKYVFFITSSLLFF 381
Cdd:cd17482 312 AEFFGFyNISGKFAAIIGPLLFG--LITQLTGSSRYGILSLIVLF 354
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
233-374 |
7.40e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.41 E-value: 7.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 233 IITIYIGQLAGSLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFG 312
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRIL 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736016517 313 LGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17503 94 QGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
63-149 |
7.44e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 41.51 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 63 SPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLST 141
Cdd:cd17374 52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFaVSGISINTLILGTEWTTPRHRALAITLTSC 131
|
....*...
gi 736016517 142 AFVSGSLL 149
Cdd:cd17374 132 FFSIGQML 139
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
6-309 |
8.89e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.13 E-value: 8.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 6 RNLIVCWFGTFVTLIGMSQIAPIMPLYIKQ-LGIHNvSAISQISGIAFGATFVVSAIfspiWGYVADRFGRKPMLLRASL 84
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFLIKDdLGLST-AQLGNLVAVPVLAGAVLRII----LGFLVDIFGPRYTTALSLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAVVVGSMGLA-QNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHAGWAL---------GVLSTAFVSGSLLGPLVG 154
Cdd:TIGR00886 76 LLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALglaagwgnmGGGVAQFVMPPIIGSLIF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 155 GYLDEFL---GLKFTFFLTGGLMLIAFFTtlFFVKEDFVPSEKK-KVESAKELWKQLPNSN--IIVTLFVSSFILQFAYY 228
Cdd:TIGR00886 156 GGGQPAHlawGWAFVIVPAGILLLPALLI--FFVGADTPPGKPAtGKLSFKEALKVFGNRHtwILALLYSVTFGSFLGVS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 229 SVEPII--TIYigqlagSLNHVAliAGMAFSASGLANIIAAPRLGKLSDRIGPQKV--VLGALILAGIVFIPQAFVKNPW 304
Cdd:TIGR00886 234 SIFAMLfkDQF------GLSKVQ--AGAYASLGGFLGSLARPAGGAISDRLGGARKllMNFLGVAMGAFLVVLGLVSDGS 305
|
....*
gi 736016517 305 QLMAL 309
Cdd:TIGR00886 306 LAAFI 310
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
28-183 |
9.74e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.95 E-value: 9.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 28 IMPLYIKQLGIHNVSAISQISGIafgaTFVVSAIFSPIWGYVADRFG-RKPMLLRASLGMAVVVGSMGLaqnVYQLIG-- 104
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGI----IFLVNIFFNLIFGILGDKIGwRRTVRWFGGVGCAISTLLFYY---VPQLFGhn 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 105 --LRILQGVITGYSTAC----TTLVATQTEkKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAF 178
Cdd:cd17337 303 ywAALIAAILFGIGLAGfvplSALMPSLAP-EHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSA 381
|
....*
gi 736016517 179 FTTLF 183
Cdd:cd17337 382 VLTLF 386
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
252-374 |
9.90e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.02 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 252 AGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRF--GLGIATAGLSPSIntlLK 329
Cdd:cd17504 33 VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAlqGIGGAVFPLAFAL---VR 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 736016517 330 KITPEKFTGRIFGFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFI 374
Cdd:cd17504 110 EEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
56-202 |
1.07e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.09 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 56 FVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLA---QNVYQLIGLRILQGVITGYSTACTTLVATQTEKKHA 132
Cdd:cd17357 59 FIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736016517 133 GWALGVLS-TAFVSGSLLGPLVGgyLDEFLG----LKFTFFLTGGLMLIAFFtTLFFVKED--FVPSEKKKVESAKE 202
Cdd:cd17357 139 RGALGSLTqIGVTLGILLGQVFG--LPSVLGtetlWPYLLFFPGIPALLQLA-ALPFFPESpkFLLISKGDEEEAEK 212
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
2-179 |
1.10e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 41.08 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 2 KIWKRNLIVCWFGT---FVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFvvsaiFSPIWGYVADRFGRKPM 78
Cdd:PRK15402 6 RLGRQALLFPLCLVlfeFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMF-----LQWLLGPLSDRIGRRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 79 LLRASLGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTActtlVATQTEKKHAGWALGVLSTAFVS-----GSLLGPLV 153
Cdd:PRK15402 81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGA----VGYAAIQESFEEADAIKITALMAnvallAPLLGPLV 156
|
170 180
....*....|....*....|....*.
gi 736016517 154 GGYLDEFLGLKFTFFLTGGLMLIAFF 179
Cdd:PRK15402 157 GAALIHVLPWRGMFVLFAALAALSFF 182
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
25-186 |
1.52e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 40.37 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 25 IAPIMPLYIKQlgihnvsaISQIsGIAFGATFVVSAIFSPIWGYVADRFG-RKPMLLraslGMAVVVGSMGL---AQNVY 100
Cdd:cd17383 18 IVPIIPDYLNE--------DIAI-GVLFASKAIVQLLVNPFSGTLIDRVGyDIPMMI----GLTVMFLSTAVfafGESYA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 101 QLIGLRILQGVITGYS-TACTTLVATQ-TEKKHAGWALGVlSTAFVS-GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIA 177
Cdd:cd17383 85 VLFFARSLQGVGSAFAdTAGLAMIADRfTEEAERSKALGI-ALAFISfGCLVAPPFGGILYEFAGKEVPFLILAFVCLLD 163
|
....*....
gi 736016517 178 FFTTLFFVK 186
Cdd:cd17383 164 GLLLLLVMK 172
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
140-366 |
1.78e-03 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 40.54 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 140 STAFVS-GSLLGPLVGGYLDEFLGLKFTFF------LTGGLMLIAFFTTLFFVKEDfVPSEKKKvESAKELWKQLPnsni 212
Cdd:PRK09848 156 SLTFVClAFLIGPSIKNSSPEEMVSVYHFWtivlaiAGMVLYFICFKSTRENVVRI-VAQPSLK-ISLQTLKRNRP---- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 213 IVTLFVSSFILQFAYYSVEPIITIYIGQLagsLNHVALIAGMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGI 292
Cdd:PRK09848 230 LFMLCIGALCVLISTFAVSASSLFYVRYV---LNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTC 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 293 VFIpQAFVKNPWQLMALRFGLGIATAGLSPSINTL--LKKITPEK---FTG-RIFGFNISAYYMGTFTGSVIGGQIAAHL 366
Cdd:PRK09848 307 GYL-LFFWVSVWSLPVALVALAIASIGQGVTMTVMwaLEADTVEYgeyLTGvRIEGLTYSLFSFTRKCGQAIGGSIPAFI 385
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
67-186 |
1.85e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 67 GYVADRFGRKPMLLRASL--GMAVVVGSMGLAQNVYQLIGLRILQGVITG-YSTACTTLVATQTEKKHAGWALGVLSTAF 143
Cdd:cd17380 55 GYLADRFGGKKVLLLAVAlwSLATLLTPLLAYSSLPLLILSRILLGLGEGvHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 736016517 144 VSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVK 186
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
61-253 |
1.90e-03 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 40.29 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 61 IFSPIWGYVADR---FG--RKPMLLRAslGMAVVVGSMGLAQNVYQLIGLRILQGVITGYSTACTT-----LVATQTEKK 130
Cdd:cd17484 47 AIKPLYGLLSDSvpiFGyrRKPYLILA--GALGALSWLALALVSNSSLALALLLLLLASLGVAFSDvvidaLVVEASRGA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 131 HAGWALGVLSTAFVS---GSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFtTLFFVKEDFVPSE---KKKVESAKELW 204
Cdd:cd17484 125 PQSLAGDLQSLCWGSsaiGGIVGSYFSGYLLELLGPRTVFAVTSFFPLLLLI-VAFFVKEERVPPHrtkENFDEQLKALW 203
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 205 KQLPNSNIIV-TLFV------SSFILQFAYYSVEPII--TIYIGqLAGSLNHVALIAG 253
Cdd:cd17484 204 ETVKQPSIWLpALFIflyqatPSSGSAMFYFMTNELGfsPEFLG-RLRVIGSIASLLG 260
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
270-320 |
1.94e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 40.14 E-value: 1.94e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 736016517 270 LGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGL 320
Cdd:cd17445 56 LGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGV 106
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
213-401 |
2.24e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 213 IVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMAFSASGLANIIAaprlGKLSDRIGPQK--VVLGALILA 290
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFS----GYLSDRTGKRKplVILGYGLSA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 291 GIVFIPqAFVKNPWQLMAL----RFGLGIATaglsPSINTLLKKITPEKFTGRIFGFNISayyMGTFtGSVIGGQIAA-- 364
Cdd:cd17370 77 LAKPLL-ALAGSWQLVLLLrileRLGKGIRT----PPRDALLADATPPSGRGKAFGLHRA---LDTL-GAVLGPLLAAll 147
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 736016517 365 ----HLGIKYVFFITS--SLLFFNAIWVYRGVYKKLKDHDKIS 401
Cdd:cd17370 148 lyllGGNYRTIFLLAAipALLALLILLFVVKEYPRPPKLRKKS 190
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
5-183 |
2.30e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.87 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 5 KRNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAISQISGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASL 84
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 85 GMAV-VVGSMGLAQNVYQLIGLRILQGVITGYSTAC-TTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYL----- 157
Cdd:cd17504 256 ISAVgLLLLALLHSSLWALVVALLLIGIGLGLAFASlPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttyt 335
|
170 180 190
....*....|....*....|....*....|....
gi 736016517 158 --------DEFLGLKFTFFLTGGLMLIAFFTTLF 183
Cdd:cd17504 336 vsitsggvPTEGAYVLAFLIGAALALAALLLSLL 369
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
53-388 |
2.73e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.29 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 53 GATFVVSAI--FSPIwGYVADRFGrKPMLLRASLGMAVVVGSMGLA----QNVYQLIGLRILQGVITG-YSTACTTLVAT 125
Cdd:PRK08633 53 NALFLLPFLllSSPA-GFLADKFS-KNRVIRIVKLFEVGLTLLIVLayylGWFWLAFAVTFLLGAQSAiYSPAKYGIIPE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 126 QTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKEDFV-------------PS 192
Cdd:PRK08633 131 LVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGLIFayrlpkvpaaapeVF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 193 EKKKVESAKELWKQL----PNSNIIVT-------LFVSSFILQfayysvepIITIYIGQLAGSLNhvALIAGMAFSASGL 261
Cdd:PRK08633 211 DKKKYLFPKLLWRNLkllrSDRVLWLAiiglsyfWFISQLAQA--------NFPAYAKEVLGLDN--TFQVQYLLAASAI 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 262 ANIIAAPRLGKLS-DRIGPQKVVLGALILA-GIVFIPqaFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGR 339
Cdd:PRK08633 281 GIGIGSLLAGRLSgRHIELGLVPLGALGLAlSLFLLP--TAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGK 358
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 736016517 340 IFGFNISAYYMGTFTGSVIGGqIAAHLGI--KYVFFITSSLLFFNAIWVYR 388
Cdd:PRK08633 359 VLAANNFLQNVGMLLFLALTT-LFSGLGLspAGLFYLIALVTLIGTLYTLL 408
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
253-388 |
3.52e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.16 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 253 GMAFSASGLANIIAAPRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKIt 332
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAV- 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 736016517 333 pEKFTGR-IFGFNISAYYMGTFTGSVIGGqIAAHLGIK-YVFFITSSLLFFNAIWVYR 388
Cdd:cd17393 116 -ERAYGRpIMSSLHAMWSLGGLAGALLGA-AAIGAGVSpGVHLLAAAVLLLLAALVAI 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
6-185 |
4.45e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 6 RNLIVCWFGTFVTLIGMSQIAPIMPLYIKQLGIHNVSAIsqisGIAFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLG 85
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLL----GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 86 MAVVVGSMGLAQNVYQLIGLRILQGV-ITGYSTACTTLVATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLK 164
Cdd:cd17329 276 FAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPG 355
|
170 180
....*....|....*....|.
gi 736016517 165 FTFFLTGGLMLIAFFTTLFFV 185
Cdd:cd17329 356 LPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
47-391 |
4.98e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 47 ISGIAFGAtfVVSAIFSpiwGYVADRFGRKPMLLRASLgmAVVVGSMG--LAQNVYQLIGLRILQGV-ITGYSTACTTLV 123
Cdd:cd17359 42 VSSALLGA--AIGALFA---GRLADRFGRRKTLLISAV--LFFISALGsaFSPNFTIFIIARIIGGLaVGGASALVPMYI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 124 ATQTEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLML-------IAFFTTLFFVKedfvpsekkk 196
Cdd:cd17359 115 AEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLgleaipaILFLLGMLFIP---------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 197 vESAKELWKQlpNSNIIVTLFVSSFILQFA------YYSVEpiitiyIGQLAGSLNHVALIAGMAFsasGLANIIAAPRL 270
Cdd:cd17359 185 -ESPRWLVSK--GKPILIIGIGLAIFQQFVginvifYYGPE------IFQNAGFSENAALLQTIGI---GVVNVIFTIIA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 271 GKLSDRIGPQKVVL-------GALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLS--PSINTLLKKITPEKFTGRIF 341
Cdd:cd17359 253 ILLVDKVGRKPLLLigsigmaISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSwgPVTWVLLSEIFPNRIRGLAM 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 736016517 342 GFNISAYYMGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYRGVY 391
Cdd:cd17359 333 GIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVP 382
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
51-346 |
6.90e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.49 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 51 AFGATFVVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNvYQLIG---------LRILQGVITG--YSTAC 119
Cdd:cd17366 45 TFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPT-YATIGvwapillllARMVQGFSTGgeYGGAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 120 TTLVATQTEKKHagwalGVLSTAFVSGSLLGPLVGGYLDEFL------------GLKFTFFLTGGLMLIAFFttlffvke 187
Cdd:cd17366 124 TFVAEYAPDRKR-----GFLGSWLEFGTLAGFILGAGLVTLLtlllteaqmldwGWRIPFLIAAPLGLVGLY-------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 188 dfvpsekkkvesakeLWKQLPNSNIIVTLFVSSFILQFAYYSVEPIITIYIGQLAGSLNHVALIAGMafsasglanIIAA 267
Cdd:cd17366 191 ---------------LRRPLLICIGLVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTM---------LVLQ 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 268 PRLGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKI-----TPEKFTGRIFG 342
Cdd:cd17366 247 PFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLpalfpTHVRYSALAIA 326
|
....
gi 736016517 343 FNIS 346
Cdd:cd17366 327 FNIS 330
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
270-388 |
6.99e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.33 E-value: 6.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 270 LGKLSDRIGPQKVVLGALILAGIVFIPQAFVKNPWQLMALRFGLGIATAGLSPSINTLLKKITPEKFTGRIFGFNISAYY 349
Cdd:cd17320 54 YGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILA 133
|
90 100 110
....*....|....*....|....*....|....*....
gi 736016517 350 MGTFTGSVIGGQIAAHLGIKYVFFITSSLLFFNAIWVYR 388
Cdd:cd17320 134 IAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
65-154 |
7.25e-03 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 38.19 E-value: 7.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 65 IWGYVADRFGRKPMLLRASLGMAVVVGSMGLAQNVYQLIGLR-ILQGVITGYSTACTTLVATQTEKKHAGWALGVLSTAF 143
Cdd:cd17375 54 IFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRfLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFF 133
|
90
....*....|.
gi 736016517 144 VSGSLLGPLVG 154
Cdd:cd17375 134 AVGIMVVALVG 144
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
57-187 |
7.59e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736016517 57 VVSAIFSPIWGYVADRFGRKPMLLRASLGMAVVVGSMGLA---QNVYQLIGLRILQGVI-------TGYSTACTTLVATQ 126
Cdd:cd17359 243 VVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAfyfAPGSQASGIVALVLILlfvaffaMSWGPVTWVLLSEI 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736016517 127 TEKKHAGWALGVLSTAFVSGSLLGPLVGGYLDEFLGLKFTFFLTGGLMLIAFFTTLFFVKE 187
Cdd:cd17359 323 FPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| |
