NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|73402281|gb|AAZ75694|]
View 

TSGA2 epididymal isoform [Mus musculus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 2.26e-32

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.68  E-value: 2.26e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  18 GGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAEtGS 97
Cdd:COG4642 139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 73402281  98 KYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIF 138
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 2.26e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.68  E-value: 2.26e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  18 GGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAEtGS 97
Cdd:COG4642 139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 73402281  98 KYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIF 138
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-148 1.46e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.11  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281   19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAeTGSK 98
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYP-NGDV 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 73402281   99 YVGTWVHGRQEgaaelihlnhryqgkfinknpvGPGKYIFDVGCEQHGEY 148
Cdd:PLN03185 103 FEGSWIQGLQE----------------------GPGKYTWANGNVYLGDM 130
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
50-71 2.32e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 40.40  E-value: 2.32e-05
                           10        20
                   ....*....|....*....|..
gi 73402281     50 SRYEGEWANDQRHGQGVYYYVN 71
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 52-74 1.23e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|...
gi 73402281    52 YEGEWANDQRHGQGVYYYVNNDT 74
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 2.26e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.68  E-value: 2.26e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  18 GGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAEtGS 97
Cdd:COG4642 139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 73402281  98 KYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIF 138
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-127 4.21e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 110.82  E-value: 4.21e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAEtGSK 98
Cdd:COG4642 163 GTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYAD-GDR 241

                        90       100       110
                ....*....|....*....|....*....|
gi 73402281  99 YVGTWVHGRQEGAAELIHLN-HRYQGKFIN 127
Cdd:COG4642 242 YEGEFKNGKRHGQGTMTYADgSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-148 2.09e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 101.19  E-value: 2.09e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  18 GGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAeTGS 97
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYA-NGD 194

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 73402281  98 KYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIFDVGCEQHGEY 148
Cdd:COG4642 195 VYEGEFKNGQRHGQGTYTYADgDRYEGEFKNGKRHGQGTLTYADGDRYEGEF 246
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-148 1.21e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 80.00  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  18 GGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAEtGS 97
Cdd:COG4642  93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD-GD 171

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 73402281  98 KYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIFDVGCEQHGEY 148
Cdd:COG4642 172 RYEGEFKNGKRHGQGTLTYANgDVYEGEFKNGQRHGQGTYTYADGDRYEGEF 223
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-148 1.46e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.11  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281   19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAeTGSK 98
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYP-NGDV 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 73402281   99 YVGTWVHGRQEgaaelihlnhryqgkfinknpvGPGKYIFDVGCEQHGEY 148
Cdd:PLN03185 103 FEGSWIQGLQE----------------------GPGKYTWANGNVYLGDM 130
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-110 8.94e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 73.71  E-value: 8.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281   19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEW-------------ANDQRH----------GQGVYYYVNNDTY 75
Cdd:PLN03185  70 GTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWiqglqegpgkytwANGNVYlgdmkggkmsGKGTLTWVSGDSY 149

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 73402281   76 TGEWFNHQRHGQGTYLYAEtGSKYVGTWVHGRQEG 110
Cdd:PLN03185 150 EGQWLDGMMHGFGVYTWSD-GGCYVGTWTRGLKDG 183
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-90 1.37e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 58.31  E-value: 1.37e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73402281   19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTY 90
Cdd:PLN03185 116 GKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
15-148 2.33e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 56.50  E-value: 2.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  15 NDLGGTYKFKNGARYIGDYVK--NKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLY 92
Cdd:COG4642  65 GGGGEGGVTAAGGGGGGGGGKgdGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTF 144

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 73402281  93 AEtGSKYVGTWVHGRQEGAAELIHLN-HRYQGKFINKNPVGPGKYIFDVGCEQHGEY 148
Cdd:COG4642 145 PN-GDVYEGEFKNGKPHGQGTLTYADgDRYEGEFKNGKRHGQGTLTYANGDVYEGEF 200
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
50-71 2.32e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 40.40  E-value: 2.32e-05
                           10        20
                   ....*....|....*....|..
gi 73402281     50 SRYEGEWANDQRHGQGVYYYVN 71
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
20-108 3.57e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 43.13  E-value: 3.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281  20 TYKFKNGA-RYIGDYVKNKKHGQGTFIYPDGS-RYEGEWANDQRHGQGVYYYVNND-TYTGEWFNHQRHGQGTYLYAETG 96
Cdd:COG2849  71 KTYYPNGQlKSEGTYKNGKLEGEWKEYYENGKlKSEGNYKNGKLHGEWKEYYENGKlKEEGNYKNGKKDGVWKYYDENGK 150

                        90
                ....*....|..
gi 73402281  97 SKYVGTWVHGRQ 108
Cdd:COG2849 151 LVKEEEYKNGKK 162
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-68 9.32e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 43.28  E-value: 9.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 73402281   19 GTYKFKNGARYIGDYVKNKKHGQGTFIYPDGSRYEGEWANDQRHGQGVYY 68
Cdd:PLN03185 139 GTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFY 188
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 52-74 1.23e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|...
gi 73402281    52 YEGEWANDQRHGQGVYYYVNNDT 74
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
73-93 2.58e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 2.58e-04
                           10        20
                   ....*....|....*....|.
gi 73402281     73 DTYTGEWFNHQRHGQGTYLYA 93
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
3-110 2.89e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 40.44  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73402281   3 YLGSGELEEEGENDLGGTYKFKNGARYIGDYVKNKKHGQGTFIYPDGS-RYEGEWANDQRHGQGVYYYVN-NDTYTGEWF 80
Cdd:COG2849  31 GYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQlKSEGTYKNGKLEGEWKEYYENgKLKSEGNYK 110

                        90       100       110
                ....*....|....*....|....*....|
gi 73402281  81 NHQRHGQGTYLYAETGSKYVGTWVHGRQEG 110
Cdd:COG2849 111 NGKLHGEWKEYYENGKLKEEGNYKNGKKDG 140
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 29-51 1.04e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.46  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|...
gi 73402281    29 YIGDYVKNKKHGQGTFIYPDGSR 51
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
27-48 1.95e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 1.95e-03
                           10        20
                   ....*....|....*....|..
gi 73402281     27 ARYIGDYVKNKKHGQGTFIYPD 48
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH