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Conserved domains on  [gi|731865|sp|P40474|]
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RecName: Full=Quinidine resistance protein 2

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 64-530 2.31e-107

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 325.68  E-value: 2.31e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    64 IAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIG 143
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   144 LACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLA 223
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   224 IGSGICFLASFLILPetkrnisgngsvtpksylnrapilvlptvrkslhldnpdyetlelptqlnllapfkilkayEICI 303
Cdd:cd17323 161 IISGFCLILIFLFLP-------------------------------------------------------------IVLL 179

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   304 LMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKyyqnwlgkkrsklle 383
Cdd:cd17323 180 LGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK--------------- 244

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   384 ehdndlnlvqriiendPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLI 463
Cdd:cd17323 245 ----------------KNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYL 308

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731865   464 VDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTSSSSILLFILLRKGKEL 530
Cdd:cd17323 309 VDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 64-530 2.31e-107

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 325.68  E-value: 2.31e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    64 IAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIG 143
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   144 LACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLA 223
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   224 IGSGICFLASFLILPetkrnisgngsvtpksylnrapilvlptvrkslhldnpdyetlelptqlnllapfkilkayEICI 303
Cdd:cd17323 161 IISGFCLILIFLFLP-------------------------------------------------------------IVLL 179

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   304 LMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKyyqnwlgkkrsklle 383
Cdd:cd17323 180 LGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK--------------- 244

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   384 ehdndlnlvqriiendPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLI 463
Cdd:cd17323 245 ----------------KNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYL 308

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731865   464 VDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTSSSSILLFILLRKGKEL 530
Cdd:cd17323 309 VDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-367 6.64e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.86  E-value: 6.64e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    56 SRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIV 135
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   136 IYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGW 215
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   216 RAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILvlptvrkslhldnpdyetlelptqlnllapfki 295
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLL--------------------------------- 210

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731865   296 lkayeicILMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRL 367
Cdd:COG2814 211 -------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-240 1.16e-22

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 93.87  E-value: 1.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:TIGR00880  17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 731865     196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPET 240
Cdd:TIGR00880  97 ALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
68-242 4.17e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.79  E-value: 4.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865      68 AFTGFFSTIAGAIYYPVLS-VIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLAC 146
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     147 AQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGS 226
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170
                  ....*....|....*.
gi 731865     227 GICFLASFLILPETKR 242
Cdd:pfam07690 162 LLAAVLLLLPRPPPES 177
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
81-240 4.29e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 70.71  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     81 YYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQ 160
Cdd:PRK11102  10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    161 A-AGISPVIAINSgIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPE 239
Cdd:PRK11102  90 GlAAAAASVVINA-LMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168


                 .
gi 731865    240 T 240
Cdd:PRK11102 169 T 169
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 64-530 2.31e-107

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 325.68  E-value: 2.31e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    64 IAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIG 143
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   144 LACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLA 223
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   224 IGSGICFLASFLILPetkrnisgngsvtpksylnrapilvlptvrkslhldnpdyetlelptqlnllapfkilkayEICI 303
Cdd:cd17323 161 IISGFCLILIFLFLP-------------------------------------------------------------IVLL 179

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   304 LMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKyyqnwlgkkrsklle 383
Cdd:cd17323 180 LGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKK--------------- 244

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   384 ehdndlnlvqriiendPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLI 463
Cdd:cd17323 245 ----------------KNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYL 308

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731865   464 VDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTSSSSILLFILLRKGKEL 530
Cdd:cd17323 309 VDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-367 6.64e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 125.86  E-value: 6.64e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    56 SRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIV 135
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   136 IYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGW 215
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   216 RAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILvlptvrkslhldnpdyetlelptqlnllapfki 295
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLL--------------------------------- 210

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731865   296 lkayeicILMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRL 367
Cdd:COG2814 211 -------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-240 1.16e-22

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 93.87  E-value: 1.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:TIGR00880  17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 731865     196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPET 240
Cdd:TIGR00880  97 ALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 48-242 6.81e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 96.03  E-value: 6.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    48 TAPPHSRFSRSFKTVLIAqcAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRR 127
Cdd:COG0477   2 SSTDAAPTRRRRRALLAL--ALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   128 PVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGA 207
Cdd:COG0477  80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 731865   208 GLSSRWGWRAIFWFLAIGSGICFLASFLiLPETKR 242
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLLALVLRLR-LPESRG 193
MFS_1 pfam07690
Major Facilitator Superfamily;
68-242 4.17e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.79  E-value: 4.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865      68 AFTGFFSTIAGAIYYPVLS-VIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLAC 146
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     147 AQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGS 226
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170
                  ....*....|....*.
gi 731865     227 GICFLASFLILPETKR 242
Cdd:pfam07690 162 LLAAVLLLLPRPPPES 177
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 68-366 1.36e-20

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 93.40  E-value: 1.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    68 AFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACA 147
Cdd:cd17474   5 FFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   148 QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSrWGWRAIFWFLAIGSG 227
Cdd:cd17474  85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   228 ICFLASFLILPETKrnisgngsvtpksylnrapilvlptvrkslhldnpdyETLELPTQLNLLAPFKILKAYEICILMLV 307
Cdd:cd17474 164 VAFLAILFLLPEPK-------------------------------------EKAKSSSATKLRDLKKALRGRGLLTFLVS 206

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 731865   308 AGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRR 366
Cdd:cd17474 207 AFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGAR 265
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 67-358 6.24e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.48  E-value: 6.24e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    67 CAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLAC 146
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   147 AQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGS 226
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   227 GICFLASFLILPETKRNIsgngsvtpksylnrapilvlptvrkslhldnpdyETLELPTQLNLLAPFKILKAYEICILML 306
Cdd:cd17325 161 LLALVLALLLLPEPRPPP----------------------------------NKRAVSAARLRSGLRLLLRDRRLLALFL 206

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 731865   307 VAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRY 358
Cdd:cd17325 207 AIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 72-241 8.92e-20

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 91.10  E-value: 8.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    72 FFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYA 151
Cdd:cd17320   9 ALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   152 QIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFL 231
Cdd:cd17320  89 QLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLL 168

                       170
                ....*....|
gi 731865   232 ASFLILPETK 241
Cdd:cd17320 169 LVLLFLPETL 178
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 68-370 1.13e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 90.95  E-value: 1.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    68 AFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACA 147
Cdd:cd06174   2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   148 QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSR--WGWRAIFWFLAIG 225
Cdd:cd06174  82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   226 SGICFLASFLILPETKRNIsgngSVTPKSYLNRAPILVLPTVRKSLHLdnpdyetlelptqlnllapfkilkayeiCILM 305
Cdd:cd06174 162 ALLAAILLLLVVPDPPESA----RAKNEEASSKSVLKLLKRVLKNPGL----------------------------WLLL 209

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 731865   306 LVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKYY 370
Cdd:cd06174 210 LAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 116-367 8.74e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 84.91  E-value: 8.74e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17324  53 LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGL 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNisgngsvTPKSYLNRAPILvlptvrksLHLDN 275
Cdd:cd17324 133 TLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK-------KPGSLGLLSSLL--------LLLRN 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   276 PdyetlelptqlnllapfKILKAYeiCILMLVAGLQFAMYTThltaLSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIA 355
Cdd:cd17324 198 P-----------------RLRLAY--LITFLLFGGFFALYTY----LAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLA 254

                       250
                ....*....|..
gi 731865   356 GRYLNWNYRRRL 367
Cdd:cd17324 255 GRLADRGGRRAL 266
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
116-529 9.20e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 84.92  E-value: 9.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:COG2271  64 PAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLilpetkrnisgngsvtpksylnrapilvlptvrkslhldn 275
Cdd:COG2271 144 PLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFW---------------------------------------- 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   276 pdyetlelptqlnllapfkilkayeicILMLVAGLQFAMYTTHLTALSTALSKQYHLTVAKVGLCYLPSGICTLCSIVIA 355
Cdd:COG2271 184 ---------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   356 GrylnwnyrrrlkyyqnWLGKKrsklleehdndlnlvqriiendpkytfnIFKARLQPAFVTLLLSSSGFCAYGWcitVK 435
Cdd:COG2271 237 G----------------WLSDR----------------------------LGRRRKLVLAIGLLLAALALLLLAL---LP 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   436 APLAAVLCMSgFASLFSNCILTFSTTLIVDLFPTK-TSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTS 514
Cdd:COG2271 270 SPALAIALLF-LAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348

                       410
                ....*....|....*
gi 731865   515 SSSILLFILLRKGKE 529
Cdd:COG2271 349 LAALLALLLLRETRK 363
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 80-241 1.05e-16

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 82.05  E-value: 1.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865      80 IYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCL 159
Cdd:TIGR00710  23 MYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     160 QAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPE 239
Cdd:TIGR00710 103 QAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPE 182


                  ..
gi 731865     240 TK 241
Cdd:TIGR00710 183 TL 184
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 118-237 2.82e-14

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 74.14  E-value: 2.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:cd17502  51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGI 130

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 731865   198 GSAFGALIGAGLSSRWGWRAIFWF--------LAIGSGICFLASFLIL 237
Cdd:cd17502 131 ASVAGPLIGGAFTDHLSWRWCFYInlpigglaLALLRTILLSSIFGFL 178
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 116-233 3.26e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 74.13  E-value: 3.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17321  50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVV 129

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLAS 233
Cdd:cd17321 130 GIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 68-236 1.69e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 72.23  E-value: 1.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    68 AFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACA 147
Cdd:cd17504   2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   148 QTYAQIIVLRCLQAAGIsPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSG 227
Cdd:cd17504  82 PNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160


                ....*....
gi 731865   228 ICFLASFLI 236
Cdd:cd17504 161 LLAALVPLI 169
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
81-240 4.29e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 70.71  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     81 YYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQ 160
Cdd:PRK11102  10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    161 A-AGISPVIAINSgIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPE 239
Cdd:PRK11102  90 GlAAAAASVVINA-LMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168


                 .
gi 731865    240 T 240
Cdd:PRK11102 169 T 169
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 116-231 8.50e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 69.55  E-value: 8.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17316  55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGW 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 731865   196 VLGSAFGALIGAGLSSR----WGWRAIFWFLAIGSGICFL 231
Cdd:cd17316 135 ALGALLAALVASLLIPLlsgdWGWRILFLIGALPALLALL 174
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 69-264 4.71e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 67.60  E-value: 4.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    69 FTGFFSTIAGAIYYPVLSVIERKF-DIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACA 147
Cdd:cd17473   6 LASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   148 QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSrWGWRAIFWFLAIgSG 227
Cdd:cd17473  86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLL-AL 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 731865   228 ICFLASFLILPETKRN---ISGNGSVTPKSYLNR--APILVL 264
Cdd:cd17473 164 PVLILVLLFLPEPARKsksAASPGAATAAALPWKrvLPIYFL 205
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
116-339 5.71e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.60  E-value: 5.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:COG2223  59 PLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGG 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLilpetkrnisgngsvtpksYLNRAPILVLPTVRKSLHldn 275
Cdd:COG2223 139 NLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL-------------------FLRDPPAGAAAAAKASLR--- 196

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 731865   276 pdyetlelptqlNLLAPFKILKAYEICILMLVAGLQFAMYTTHltaLSTALSKQYHLTVAKVGL 339
Cdd:COG2223 197 ------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSW---LPPYLVDQFGLSAATAGL 245
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 33-237 1.09e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.45  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    33 LALTRTESVKPEPEITAPPHSRFSRSFKTVL----IAQCAFTGFFSTIAGAIYYPVLSV-IERKFDIDEELVNVTVVVYF 107
Cdd:cd17325 166 LALLLLPEPRPPPNKRAVSAARLRSGLRLLLrdrrLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQG 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   108 VFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGY 187
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   188 VGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIgsgICFLASFLIL 237
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA---LLLLAAVLFL 372
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 116-239 3.31e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.07  E-value: 3.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:TIGR00895  71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGY 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 731865     196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGIcfLASFLI--LPE 239
Cdd:TIGR00895 151 PIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLMrfLPE 194
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 75-248 5.61e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 64.56  E-value: 5.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    75 TIAGaiyypVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQII 154
Cdd:cd17328  17 TIAG-----VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   155 VLRCLQAAGISPVIAINSGIMGDVTTRAER---------GGYVGYVAGFqVLGSAFGALIGaglssrwGWRAIFWFLAIG 225
Cdd:cd17328  92 LFRALVGIGEASYSPIAPTIIADLFPKEKRtralgvfyfAIPLGSGLGY-VVGGLVAQATG-------GWRWAFRVTGVL 163

                       170       180
                ....*....|....*....|...
gi 731865   226 SGICFLASFLILPETKRNISGNG 248
Cdd:cd17328 164 GVLLAILLLLFVREPPRGAAEGG 186
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 116-267 3.01e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.84  E-value: 3.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17489  50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLAT 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILVLPTV 267
Cdd:cd17489 130 TLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPAL 201
emrD PRK11652
multidrug transporter EmrD;
80-240 3.46e-09

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 58.77  E-value: 3.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     80 IYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCL 159
Cdd:PRK11652  26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    160 QAAGISPVIAINSGIMGDVTTRAERGGYVGYVAgFQVLGSAFGA-LIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILP 238
Cdd:PRK11652 106 QGLGTGVGGVMARTLPRDLYEGTQLRHANSLLN-MGILVSPLLApLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184


                 ..
gi 731865    239 ET 240
Cdd:PRK11652 185 ET 186
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 116-232 5.84e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.98  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17365  53 LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 731865   196 VLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLA 232
Cdd:cd17365 133 PLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
118-240 8.59e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 57.64  E-value: 8.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:PRK15402  69 GPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALL 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 731865    198 GSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPET 240
Cdd:PRK15402 149 APLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET 191
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 117-242 2.01e-08

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 56.49  E-value: 2.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   117 MGGFADSLGRRPVVLVAIviyFGACIG---LACAQTYAQIIVLRCLqaAGIS-PVIAINSGIMGDVTTRAERGGYVGYVA 192
Cdd:cd17388  58 LGALSDRFGRRPVLLLSL---AGAALDyllMAFAPTLWWLYLGRII--AGITgATGAVAAAYIADVTPPEQRARNFGLLG 132

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   193 GFQVLGSAFGALIGaGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKR 242
Cdd:cd17388 133 AAFGLGFIAGPALG-GLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLP 181
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 109-242 2.36e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 56.05  E-value: 2.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   109 FQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSgIMGDVTTRAERGGYV 188
Cdd:cd17330  46 GQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQA-YIADITDEEERAKAF 124

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 731865   189 GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKR 242
Cdd:cd17330 125 GIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRR 178
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
111-258 4.38e-08

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 55.41  E-value: 4.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    111 GLAPT--FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYV 188
Cdd:PRK10473  50 GMAAAmlFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVL 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 731865    189 GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPK----SYLNR 258
Cdd:PRK10473 130 SLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRPARAPAASSKPRenseSLLNR 203
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 116-271 1.85e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.46  E-value: 1.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:cd17371  53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGW 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   196 VLGSAFGALIGAGL----SSRWGWRAIFWFLAIGSGIC-FLASFLILPET---KRNISGNGSVTPKSYLNRAPILVLPTV 267
Cdd:cd17371 133 AVGWLLATLLAALLfpllPPEIAWRVLFLLGALPALLVlFIRRFVKEPPQwqaARAARRHFADRPSLRELFSPPLLRTTL 212


                ....
gi 731865   268 RKSL 271
Cdd:cd17371 213 LASL 216
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
43-200 2.15e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.05  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    43 PEPEITAPPHSRFSRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVI-ERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFA 121
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYlQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 731865   122 DSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSA 200
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 118-238 3.92e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 52.19  E-value: 3.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:cd17319  59 GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPL 138

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 731865   198 GSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILP 238
Cdd:cd17319 139 GAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 117-243 4.45e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 52.22  E-value: 4.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   117 MGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGispviAINSGIM---GDVT---TRAERGGYVGY 190
Cdd:cd17472  52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-----AISSVVMallADLTreeNRTKAMALIGA 126

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 731865   191 VAGFQVlgsAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRN 243
Cdd:cd17472 127 SIGIAF---AISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKI 176
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 130-238 9.56e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 51.10  E-value: 9.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   130 VLVAIVIYFGACIGLACA-QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAG 208
Cdd:cd17327  73 WLSVFIVLWGLLTLLTAAvKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYG 152

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 731865   209 LSSR------WGWRAIFWFLAIGSGICFLASFLILP 238
Cdd:cd17327 153 VFKIlgvgglAGWRWLFIIEGLITIIIGLVIFFWLP 188
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 120-235 1.01e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 51.04  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   120 FADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGS 199
Cdd:cd17503  54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 731865   200 AFGALIGAGLSSRWGWRAIFWF-LAIGSGICFLASFL 235
Cdd:cd17503 134 AIGPTLGGWLTDNLSWRWIFYInLPIGILALLLAPLL 170
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 110-235 1.87e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 50.70  E-value: 1.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   110 QGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQ--AAGISPVIAInsgIMGDVTTRAERGGY 187
Cdd:cd06179  45 QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIgiGAGTQGLGAA---VASELVPNKYRGLV 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   188 VGYVAGFQVLGSAFGALIGAGL--SSRWGWRAIFWFLAIGSGICFLASFL 235
Cdd:cd06179 122 QGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFF 171
Sugar_tr pfam00083
Sugar (and other) transporter;
116-242 4.65e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.19  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACA---QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYva 192
Cdd:pfam00083  65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL-- 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 731865     193 gFQvLGSAFGALIGAGL-------SSRWGWRAIFWFLAIGSGICFLASFLiLPETKR 242
Cdd:pfam00083 143 -YQ-LAITFGILLAYIFglglnktSNSDGWRIPLGLQLVPALLLIIGLLF-LPESPR 196
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 36-232 6.87e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 6.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    36 TRTESVKPEPEITAPPHSRFSRSFKTVLIAQCAFT-GFFStiagaiyYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAP 114
Cdd:cd17370 179 EYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFAlGNFS-------FAFLILRAQELGLSAALIPLLYALFNLVYALAA 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGF 194
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTV 331

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 731865   195 QVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLA 232
Cdd:cd17370 332 VGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 118-241 9.10e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.99  E-value: 9.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:cd17329  56 GRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINL 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 731865   198 GSAFGALIGaGLSSRWGWRAIFWFLAIGSGICFLASFLILPETK 241
Cdd:cd17329 136 GVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETR 178
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 111-237 1.03e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.03  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   111 GLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQ--AAGISPviaiNSGIMGDVTTRAERGGYV 188
Cdd:cd17391  50 AIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQgvFSGYVP----NATALIASQTPKEKSGWA 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   189 -GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWflaIGSGICFLASFLIL 237
Cdd:cd17391 126 lGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFF---ITGGLLFLAFLLTL 172
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 61-237 1.42e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 47.26  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    61 TVLIAQcaftgFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGA 140
Cdd:cd17476   2 TISGAQ-----LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIW 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   141 CIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYV-GYVAGFQVLGSAFGALIGAGLSSRWGWRAIF 219
Cdd:cd17476  77 SLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156

                       170
                ....*....|....*...
gi 731865   220 WFLAIGSGICFLASFLIL 237
Cdd:cd17476 157 WFLAILAAIVAVAAIFWT 174
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 112-237 1.53e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.26  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   112 LAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQA---AGISPviAINSGIMgDVTTRAERGGYV 188
Cdd:cd17391 255 LSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGlatGGLLP--AINSLLA-KITPKEVAGRIF 331

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 731865   189 GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFwflaIGSGICFLASFLIL 237
Cdd:cd17391 332 GYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF----VVTALLVLLNAIWS 376
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 116-242 1.94e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 47.18  E-value: 1.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGY----- 190
Cdd:cd17359  55 FAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmi 134

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 731865   191 VAGfQVLGSAFGALIGAGLSSRW----GWRAIFWFLAIGSgICFLASFLILPETKR 242
Cdd:cd17359 135 VFG-QLLAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPA-ILFLLGMLFIPESPR 188
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 115-242 2.49e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 46.86  E-value: 2.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGF-----ADSLGRRPVVLVAIVIY-FGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYV 188
Cdd:cd17356  58 SFFGALissflSDRIGRKKSIQIGCVIYiIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLV 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 731865   189 GYVAGFQVLGSAFGALIGAGLSSRWG---WRaIFWFLAIGSGICFLASFLILPETKR 242
Cdd:cd17356 138 SLYQLAITIGILVAYCINYGTHKLDGsaqWR-IPLGLQIVWGLLLLIGMFFLPESPR 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
57-242 3.52e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.03  E-value: 3.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    57 RSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIErkFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVI 136
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ--FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   137 YFGACIGLA-CAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSSRWG- 214
Cdd:COG2223 281 MALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGs 360

                       170       180
                ....*....|....*....|....*...
gi 731865   215 WRAIFWFLAIGSGICFLASFLILPETKR 242
Cdd:COG2223 361 YTAAFLVFAVLALVALVLTLLLYRRPRR 388
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
109-245 4.48e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    109 FQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAgISPVIAINSGIMGDVTTRAERGGYV 188
Cdd:PRK09874  66 FSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWAL 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 731865    189 GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNIS 245
Cdd:PRK09874 145 GTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVS 201
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
111-242 4.54e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.02  E-value: 4.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   111 GLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISpviAINSGIMGDVTTR--AERGGYV 188
Cdd:COG2807  67 GLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA---VGNVLLPGLIKRWfpDRVGLMT 143

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 731865   189 G-YVAGFQvLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKR 242
Cdd:COG2807 144 GlYTAAMG-LGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA 197
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 116-242 8.11e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.87  E-value: 8.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQ--AAGISPVIAinsGIMGDVTTRAERGGYVGYVAG 193
Cdd:cd17315  53 FGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLglGVGLASVLV---PLYISEIAPAKIRGALGTLNQ 129

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 731865   194 FQVLGSAFGALI---GAGLSSRWGWRAIFWFLAIGSGICFLASFlILPETKR 242
Cdd:cd17315 130 LMITFGILLAYLlglALSLSPPGWWRLMFALAAVPALLQLLLMF-FLPESRA 180
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 110-240 1.28e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 44.57  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   110 QGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLqaAGISP-VIAINSGIMGDVTTRAERGGYV 188
Cdd:cd17389  77 QFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIV--GGISKgNVSLSTAIVADVTSPKKRSKGM 154

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 731865   189 GYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFL--AIGSGICFLASFLI----LPET 240
Cdd:cd17389 155 ALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSmpALFALVLALADLLFifffLPET 212
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 117-242 1.61e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 44.29  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   117 MGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQI--------IVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYV 188
Cdd:cd17368  60 LGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731865   189 GYVAGFQVLGSAFGALIGAGLS--------SRWGWRAIFWF-LAIGSGICFLASFLILPETKR 242
Cdd:cd17368 140 SWQSASQQVAIVAGALVGYLLSltltaealAEWGWRIPFFIgLLIIPLGLWLRRSLEETEAFL 202
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
116-257 2.22e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 43.73  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    116 FMGGFA----------DSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDV--TTRAE 183
Cdd:PRK11043  50 FLAGFAlgqllwgplsDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRypAQKAN 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 731865    184 R--GGYVGYVAgfqvLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLN 257
Cdd:PRK11043 130 RvfATIMPLVA----LSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQDALTFKQLLK 201
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 116-215 2.31e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.20  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQ 195
Cdd:TIGR01299 221 FWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFW 300

                          90       100
                  ....*....|....*....|
gi 731865     196 VLGSAFGALIGAGLSSRWGW 215
Cdd:TIGR01299 301 MIGGIYAAAMAWAIIPHYGW 320
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 178-256 2.94e-04

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 43.37  E-value: 2.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   178 VTTRAERGGYVGYVAGFQVLGSAFGALIGAG----LSSRWGWRAIFWFLAIGSGICFLASFL---ILPETKRNISGNGSV 250
Cdd:cd17485 116 LAVELLTPEERGLGNAAQVVGYKLGSLLGGGgllwLYDLIGWQSLLLSLAALYLLLLLPVLFlreLELPQQPPASERGAA 195


                ....*.
gi 731865   251 TPKSYL 256
Cdd:cd17485 196 LKASLR 201
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 116-239 2.95e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.38  E-value: 2.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPViaiNSGimgdvTTRA--------ERGGY 187
Cdd:cd17475  50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV---QPG-----GGRAimrwfpprERGLA 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 731865   188 VGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPE 239
Cdd:cd17475 122 MGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 62-237 3.11e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.03  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    62 VLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGAC 141
Cdd:cd17355   3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   142 IGLACAQTYAQIIVLRCLQAAGISPVIAInsGIMGDVTTRA---ERGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAI 218
Cdd:cd17355  83 VLLALATSLWQLYLLWGLLGGGGAGTLAA--VAFATVAAWWferRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160

                       170
                ....*....|....*....
gi 731865   219 FWFLAIGSGICFLASFLIL 237
Cdd:cd17355 161 LLVLALLALLVLVPVLLLL 179
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 62-237 3.17e-04

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 43.38  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    62 VLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSlGRRPVVLVAIVIYFGac 141
Cdd:cd17336   3 VFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGR-GHRPRWIGIGSILMG-- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   142 IG-LACAQTYAqIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAGLSS--------- 211
Cdd:cd17336  80 LGcFLLALPHF-LFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRiyvdfsrvp 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 731865   212 --------RWGWraiFWFLA--IGSGICFLASFLIL 237
Cdd:cd17336 159 lgitpddpRWIG---AWWLGflILGILLLIVSIPLF 191
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
117-219 3.42e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.99  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    117 MGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQV 196
Cdd:PRK09874 278 LGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRD 357

                         90       100
                 ....*....|....*....|...
gi 731865    197 LGSAFGALIGAGLSSRWGWRAIF 219
Cdd:PRK09874 358 IGNVTGPLMGAAISANYGFRAVF 380
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
116-243 3.57e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPV-IAINSgiMGDVTTRAERGGYVGYVAGF 194
Cdd:COG0738  62 PAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANP--YVAALGPETAASRLNLLHAF 139

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 731865   195 QVLGSAFGALIGAGLSSR---WGWRAIFWFLAIGS-GICFLASFLILPETKRN 243
Cdd:COG0738 140 FSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLlLLALLFLRSKLPEIEEE 192
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 49-235 3.92e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.90  E-value: 3.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    49 APPHSRFSRSFKTVLIA---QCAFTGFFSTIAgaIYypVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLG 125
Cdd:cd17369 217 APLVEVLRRHWRALLLAiglRLAENVLFYLFT--TF--ALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVG 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   126 RRPVVLV----AIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMG---DVTTRaerggYVGYVAGFQ--- 195
Cdd:cd17369 293 RRPVYLAgallAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAelfPTRVR-----YTGASLGYQlga 367

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 731865   196 VLGSAFGALIGAGLSSRWG-WRAIFWFLAIGSGICFLASFL 235
Cdd:cd17369 368 ILGGGFAPLIATALVAATGsWWPVALYLAALAVISLVAALF 408
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 118-242 6.32e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 42.34  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:cd17362  60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVL 139

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 731865   198 GSAFGALIGAGL-SSRWGWRaifWFLAIGSGICFLASF--LILPETKR 242
Cdd:cd17362 140 GILLGYVSGYAFaDVVGGWR---YMYGLAAPPALLLGIgmWFLPPSPR 184
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 116-242 7.25e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.87  E-value: 7.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGF-ADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGF 194
Cdd:cd17360  53 AIGGWlNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLF 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 731865   195 QVLGSAFGALIGAGLSS-RWGWRAIFWFLAIGSgICFLASFLILPETKR 242
Cdd:cd17360 133 ITGGQFVAYVINGAFSYlPGGWRWMLGLAAVPA-VLQFIGLLFLPESPR 180
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 115-354 9.31e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 9.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGFADSLG-RRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLqaagispVIAINSGIMG----------DVTTRAE 183
Cdd:cd17471  50 QWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVV-------LLSLGAAAFPqlfalareyaDRSSGRD 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   184 RGGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILV 263
Cdd:cd17471 123 ATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLL 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   264 LPTVrkslhldnpdyetlelptqlnllapfkilkayeICILMLVAGlqfAMYtthLTALSTALSKQYHLTVAKVGLCYlp 343
Cdd:cd17471 203 LLFA---------------------------------AFTLLFAAN---SMY---IIAMPLYVTNELGGSESWVGLLF-- 241

                       250
                ....*....|.
gi 731865   344 sGICTLCSIVI 354
Cdd:cd17471 242 -GLAAALEIPI 251
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 116-238 1.25e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.03  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTtraeRGGYVGYVAGFQ 195
Cdd:cd17317  44 LFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV----GPKYRSFVGILF 119

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 731865   196 VLGSAFGALIGAGLSSRWG-WRAIFWFLAIgSGICFLASFLILP 238
Cdd:cd17317 120 GLFWALGYMLLALLAYLIRdWRWLQLAISL-PGLLFLLLLWWLP 162
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
117-242 1.28e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 41.35  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    117 MGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQV 196
Cdd:PRK15403  71 LGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVL 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 731865    197 LGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKR 242
Cdd:PRK15403 151 VAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 124-234 1.51e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   124 LGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGA 203
Cdd:cd06174 267 IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGP 346

                        90       100       110
                ....*....|....*....|....*....|..
gi 731865   204 LIGAGLSSR-WGWRAIFWFLAIGSGICFLASF 234
Cdd:cd06174 347 LLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 116-240 1.57e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 41.13  E-value: 1.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQI--------IVLRCLQAAGISPVIAINSGIMGDVTTRAERGGY 187
Cdd:cd17367  59 LFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFY 138

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 731865   188 vgyvAGFQVLGSAFGALIGAGLS------------SRWGWRAIFwflAIGSGICFLASFL--ILPET 240
Cdd:cd17367 139 ----SSFQYVTLIGGQLLALGVLlvlqhtlgedqmAAWGWRIPF---LLGGVLAVVVLWLrrGLEET 198
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 116-242 1.58e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.02  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAG---ISPVIAInsgIMGDVTTRAERGGYVGYVA 192
Cdd:cd17358  60 LSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGggaASVVVPV---YIAEIAPKNVRGALGSLNQ 136

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   193 GFQVLGSAFGALIGAGLSsrwgWRAIFWFLAIGSGIcFLASFLILPETKR 242
Cdd:cd17358 137 LLVNIGILLGYVLGSFLP----WRTLALIGAIPPVV-FLILLFFIPESPR 181
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 116-215 1.59e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 40.94  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYfGACIGLAC-AQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGF 194
Cdd:cd17363  53 VWGGLADKLGRKQCLLIALSVN-GVFAFLSSfVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMF 131

                        90       100
                ....*....|....*....|.
gi 731865   195 QVLGSAFGALIGAGLSSRWGW 215
Cdd:cd17363 132 WMIGGLYASAMAWAIIPHYGW 152
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 111-254 2.11e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    111 GLAP-TFMGG-FADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISP----VIAINSGIMGDvttrAER 184
Cdd:PRK11551  62 GLLPgALLGGrLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGalpnLIALTSEAVGP----RLR 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    185 GGYVGYVAGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKS 254
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA 207
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 118-248 2.12e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 40.78  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   118 GGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVL 197
Cdd:cd17439  55 GGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMI 134

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731865   198 GSAFGALIGAGLSSRWGWR------------AIFWFLAIGSGICFLASFLILPETKRNISGNG 248
Cdd:cd17439 135 GGIYASAMAWAIIPHYGWSfqmgsayqfhswRVFVLVCAFPSVFAIGALTTMPESPRFFLENG 197
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 115-240 2.82e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.21  E-value: 2.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGIS--PVIAInsgIMGDVTTRAERGGYVGYVA 192
Cdd:cd17372  52 YLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGggPQLAS---WYLEFLPAKSRGTWMVLFS 128

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 731865   193 GFQVLGSAFGALIGAGLSSRWGWRaifWFLAIGS--GICFLASFLILPET 240
Cdd:cd17372 129 VFWTVGTIFEASLAWLVMPRLGWR---WLLAFSSvpSSLLLVFYRWTPKT 175
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 116-339 2.89e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.28  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPvvlvAIVIYFGACIG----LACAQTYAQIIVLR-------CLQAAgispviainSGIMGDVTTRAER 184
Cdd:cd17331  54 LFGRFGDLFGPRA----ALVLSFLSSALsyllLAFASSVPMLFLSRlpsvfmhAMQAA---------QMVVTDLTDPGER 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   185 GGYVGYVA-----GFqVLGSAFGALigagLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISG---NGSVTPKSYL 256
Cdd:cd17331 121 AAALGRLGlsygiGM-VVGSFLGGL----LTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREkeaKESASPPSVF 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   257 NRAPILVLptvrkslhldnpdyetlelptqlnllapFKILKAYEICILMLVAGLQFAMYTTHLTALSTalsKQYHLTVAK 336
Cdd:cd17331 196 NLKEILRL----------------------------LRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAM---DFFGLTPEE 244


                ...
gi 731865   337 VGL 339
Cdd:cd17331 245 NGY 247
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
116-236 3.24e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.86  E-value: 3.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLG-RRPVVLVAIVIYFGACIGLACAQTYAQIIVLrCLQAAGISPVIAINSGIMGDVT-TRAERGGYVGYVAG 193
Cdd:COG2807 269 LVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQS 347

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 731865   194 FQVLGSAFGALIGAGLSSRWG-WRAIFWFLAIGSGICFLASFLI 236
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 117-215 3.51e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.91  E-value: 3.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   117 MGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQV 196
Cdd:cd17438  54 WGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWM 133

                        90
                ....*....|....*....
gi 731865   197 LGSAFGALIGAGLSSRWGW 215
Cdd:cd17438 134 IGGLYASAMAWSIIPHYGW 152
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 115-364 3.64e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.00  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     115 TFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISpviainSGIMGDVTTRAERGGyVGYVAGF 194
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIG------GIWVQAVVLNTEFLP-KKQRAIV 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     195 QVLGS---AFGALIGAGLSsrW---GWRAIFWFLAIGSGICFLASFlILPETKRNISGNGSVT-PKSYLNRA---PILVL 264
Cdd:TIGR00898 218 GTLIQvffSLGLVLLPLVA--YfipDWRWLQLAVSLPTFLFFLLSW-FVPESPRWLISQGRIEeALKILQRIakiNGKKL 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     265 PTVRKSLHLDNPDYETLELPTQLNLLAPFKILKAYeICILMLVAGLQFAMYTthLTALSTALSKQYHLTVAKVGLCYLPS 344
Cdd:TIGR00898 295 PAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTT-LCLMMLWFTTAFSYYG--LVLDLGNLGGNIYLDLFISGLVELPA 371

                         250       260
                  ....*....|....*....|
gi 731865     345 GICTLCSIviagRYLNWNYR 364
Cdd:TIGR00898 372 KLITLLLI----DRLGRRYT 387
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 116-237 3.71e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 3.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTraergGYVGYVAGF- 194
Cdd:cd17471 254 LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-----GQPGLATTLy 328

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 731865   195 ---QVLGSAFGALIGAGLSSRWGWRAIFWFLAIgsgICFLASFLIL 237
Cdd:cd17471 329 snaSRIGSLLGGLLAGVIAQYFGYRAVFLVCAV---LALLALVLLL 371
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 116-244 4.91e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 4.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAeRGGYVGYvagFQ 195
Cdd:cd17478  50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSI---FS 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 731865   196 V---LGSAFGALIGAGLSSRWGWRAIFWFLAIGsGICFLASFLILPETKRNI 244
Cdd:cd17478 126 VggnLGFALGPLIAAALVALFGGLGLLILLIIP-GLAVALLLLRLRPLKKPE 176
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 115-237 5.57e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.13  E-value: 5.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLqaAGI-SPVIAINSGIMGDVTTRAERGGYVGYVAG 193
Cdd:cd17390  49 PLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP--LGIfKHTQSLCKAYLSDLVSEQERSRVLGRFNA 126

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 731865   194 FQVLGSAFGALIGAGLSsrwGWRAIFWFLAIGSGICFLASFLIL 237
Cdd:cd17390 127 ASSLGFILGPVVGGHLA---ETDGGFYYVALLCSAIFILNAGLV 167
MFS_1 pfam07690
Major Facilitator Superfamily;
36-203 5.79e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865      36 TRTESVKPEPEITAPPHSRFsRSFKTVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPT 115
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAW-KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865     116 FMGGFADSLGRRPVVLVAIVIYFGACIGLACA---QTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVA 192
Cdd:pfam07690 254 LLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN 333

                         170
                  ....*....|.
gi 731865     193 GFQVLGSAFGA 203
Cdd:pfam07690 334 TAGSLGGALGP 344
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 112-236 6.08e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 6.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   112 LAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYV 191
Cdd:cd06173 259 LGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVY 338

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 731865   192 AGFQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLI 236
Cdd:cd06173 339 NALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 39-237 8.85e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 8.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    39 ESVKPEPEITAPPHSRFSRSFKTVLIAQCAFTGFFSTIagaIYYPVLS----VIERKFDIDEELVNVTVVVYFVFQGLAP 114
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFF---LYFAFLTylpfLLELLYGISPIIIGLLFAGWSVLLALGS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   115 TFMGGF-ADSLGRRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAG 193
Cdd:cd17474 252 LFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNF 331

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 731865   194 FQVLGSAFGALIGAGLSSRWGWRAIFWflaIGSGICFLASFLIL 237
Cdd:cd17474 332 VRFLGQAVGPLLFGLLLEIFGLSAPFL---VGAAIALAAAVLLA 372
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 61-234 9.29e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 9.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865    61 TVLIAQCAFTGFFSTIAGAIYYPVLSVIERKFDIDEelVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGA 140
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPAT--SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 731865   141 CIGLACAQTY--AQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIGAG-LSSRWGWRA 217
Cdd:cd17316 257 ALPLFYLLSGspTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALlLASTGGTGV 336

                       170
                ....*....|....*..
gi 731865   218 IFWFLAIGSGICFLASF 234
Cdd:cd17316 337 PALILALLAIVALIVAL 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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