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Conserved domains on  [gi|731417558|ref|XP_010660345|]
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uncharacterized protein LOC104881553 [Vitis vinifera]

Protein Classification

heavy metal-associated domain-containing protein( domain architecture ID 10086127)

heavy metal-associated domain-containing protein such as heavy metal-associated isoprenylated plant proteins and Saccharomyces cerevisiae copper transport protein ATX1, which shuttles copper to the transport ATPase CCC2 and protects against oxygen toxicity

Gene Ontology:  GO:0046872
PubMed:  12594858|10404590|8091505|9437429

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 15-74 1.46e-12

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


:

Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 59.93  E-value: 1.46e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731417558  15 VLKVHV-NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGN--VDAATLINKLVRRGKHAE 74
Cdd:cd00371    1 ELSVEGmTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 15-74 1.46e-12

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 59.93  E-value: 1.46e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731417558  15 VLKVHV-NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGN--VDAATLINKLVRRGKHAE 74
Cdd:cd00371    1 ELSVEGmTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
HMA pfam00403
Heavy-metal-associated domain;
15-68 1.90e-11

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 56.86  E-value: 1.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 731417558   15 VLKVH-VNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDaATLINKLVR 68
Cdd:pfam00403   1 TFRVSgMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAE-STKLEKLVE 54
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
21-74 9.32e-10

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 52.98  E-value: 9.32e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 731417558  21 NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGN---VDAATLINKLVRRGKHAE 74
Cdd:COG2608   12 TCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAGYEVE 68
PLN02957 PLN02957
copper, zinc superoxide dismutase
 18-75 7.70e-05

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 42.05  E-value: 7.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 731417558  18 VHVNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDAATLINKLVRRGKHAEL 75
Cdd:PLN02957  12 VDMKCEGCVAAVKNKLETLEGVKAVEVDLSNQVVRVLGSSPVKAMTAALEQTGRKARL 69
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 20-61 1.41e-03

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 35.98  E-value: 1.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 731417558   20 VNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDAAT 61
Cdd:TIGR00003   9 MSCNHCVDKIEKFVGEIEGVSKVKVQLEKEKVVVEFDAPNVS 50
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 15-74 1.46e-12

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 59.93  E-value: 1.46e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731417558  15 VLKVHV-NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGN--VDAATLINKLVRRGKHAE 74
Cdd:cd00371    1 ELSVEGmTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIEDAGYKAR 63
HMA pfam00403
Heavy-metal-associated domain;
15-68 1.90e-11

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 56.86  E-value: 1.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 731417558   15 VLKVH-VNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDaATLINKLVR 68
Cdd:pfam00403   1 TFRVSgMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAE-STKLEKLVE 54
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
21-74 9.32e-10

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 52.98  E-value: 9.32e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 731417558  21 NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGN---VDAATLINKLVRRGKHAE 74
Cdd:COG2608   12 TCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEEAGYEVE 68
PLN02957 PLN02957
copper, zinc superoxide dismutase
 18-75 7.70e-05

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 42.05  E-value: 7.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 731417558  18 VHVNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDAATLINKLVRRGKHAEL 75
Cdd:PLN02957  12 VDMKCEGCVAAVKNKLETLEGVKAVEVDLSNQVVRVLGSSPVKAMTAALEQTGRKARL 69
TIGR00003 TIGR00003
copper ion binding protein; This model describes an apparently copper-specific subfamily of ...
 20-61 1.41e-03

copper ion binding protein; This model describes an apparently copper-specific subfamily of the metal-binding domain HMA (pfam00403). Closely related sequences outside this model include mercury resistance proteins and repeated domains of eukaryotic eukaryotic copper transport proteins. Members of this family are strictly prokaryotic. The model identifies both small proteins consisting of just this domain and N-terminal regions of cation (probably copper) transporting ATPases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 188014 [Multi-domain]  Cd Length: 66  Bit Score: 35.98  E-value: 1.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 731417558   20 VNCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDAAT 61
Cdd:TIGR00003   9 MSCNHCVDKIEKFVGEIEGVSKVKVQLEKEKVVVEFDAPNVS 50
copA PRK10671
copper-exporting P-type ATPase CopA;
12-78 2.20e-03

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 38.18  E-value: 2.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 731417558  12 QTCVLKVH-VNCNGCKQKVKKLLSRIEGVysvsidaEQQKVT-----VTGNVDAATLINKLVRRGKHAELWPP 78
Cdd:PRK10671   3 QTIDLTLDgLSCGHCVKRVKESLEQRPDV-------EQADVSiteahVTGTASAEALIETIKQAGYDASVSHP 68
copA PRK10671
copper-exporting P-type ATPase CopA;
21-89 7.56e-03

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 36.64  E-value: 7.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 731417558  21 NCNGCKQKVKKLLSRIEGVYSVSIDAEQQKVTVTGNVDAATLINKLVRRGKHAELWPPSNHQNQNQQHS 89
Cdd:PRK10671 109 SCASCVSRVQNALQSVPGVTQARVNLAERTALVMGSASPQDLVQAVEKAGYGAEAIEDDAKRRERQQET 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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