|
Name |
Accession |
Description |
Interval |
E-value |
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-452 |
0e+00 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 941.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSK 80
Cdd:PRK11273 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:PRK11273 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 161 WNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELT 240
Cdd:PRK11273 161 WNCAHNVGGGLPPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQELT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN 320
Cdd:PRK11273 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 321 RGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:PRK11273 321 RGATGVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 729897337 401 SAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRRHEQLLQERNGG 452
Cdd:PRK11273 401 SAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKRNGG 452
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
3-440 |
0e+00 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 816.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 3 SIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFI 82
Cdd:TIGR00712 1 SIFKPAPHIARLPAAKIDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSKGELGFALSAISIAYGFSKFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 83 MGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN 162
Cdd:TIGR00712 81 MGSVSDRSNPRVFLPAGLILSAAVMLLMGFVPWATSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 163 CAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAK 242
Cdd:TIGR00712 161 CAHNIGGGIPPLLVLLGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEYRNDYPDDYNEKAEQELTAK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 243 QIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRG 322
Cdd:TIGR00712 241 EIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 323 ATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 402
Cdd:TIGR00712 321 ATGVFFMTLVTIAVIVYWMNPAGNPLVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 729897337 403 IVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 440
Cdd:TIGR00712 401 IVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 438
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-435 |
0e+00 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 623.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQyGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND 185
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 --WHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYN-EKAEQELTAKQIFMQYVLPNKLLWYIAIAN 262
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADgEEEEQELSAWEIFVKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMN 342
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 343 PagNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIG 422
Cdd:cd17345 321 P--NVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLLA 398
|
410
....*....|...
gi 729897337 423 GSILAVILLIVVM 435
Cdd:cd17345 399 SCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-417 |
0e+00 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 515.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 35 FFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV 113
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEiGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 114 PwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMP 193
Cdd:TIGR00881 81 T----SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 194 AFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 274 DWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMIC 353
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729897337 354 MIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSvAASAIVGYTVDFFGWDGGF 417
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGI-LAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-435 |
1.15e-129 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 379.31 E-value: 1.15e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEiGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:cd17312 81 ANIFMGF----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY-G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFAFAMMRDTPqscglppieeykndypddynekaeqeltakqifmqyvlpnKLLWYIAIANVFV 265
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSP----------------------------------------PYVWVLSLAYAFV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPaG 345
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFP-H 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 346 NPTVDMICMIVIGFLIYGPVMLIGLHALE-LAPKKAAGTAAGFTGLFGYLGGSVAASaIVGYTVDFFGWDGGFMVMIGGS 424
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGL-PLGYIIDHYGWSTVFYFLISAA 353
|
410
....*....|.
gi 729897337 425 ILAVILLIVVM 435
Cdd:cd17312 354 LLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
7-431 |
2.91e-103 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 314.34 E-value: 2.91e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 7 PAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMP-YLVEQGFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:PRK11663 1 PADAPLITDKHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPeMLADLGLSRSDIGLLATLFYITYGVSKFVSGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 86 VSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAH 165
Cdd:PRK11663 81 VSDRSNARYFMGIGLIATGIINILFGF----SSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 166 NVGGGIPPLLflLGMAWFN-DWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQI 244
Cdd:PRK11663 157 NVGGALIPLV--VGAIALHyGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 245 FMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGAT 324
Cdd:PRK11663 235 LTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 325 GVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIv 404
Cdd:PRK11663 315 NLIFAAGILLSVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPL- 393
|
410 420
....*....|....*....|....*...
gi 729897337 405 GYTVDFFGWDGGFMVM-IGGSILAVILL 431
Cdd:PRK11663 394 AKVLEIWHWTGFFVVIsIAAGISALLLL 421
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
13-448 |
2.45e-87 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 274.23 E-value: 2.45e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 13 RLPAAEIDPTYRRLRW-----QIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSV 86
Cdd:PRK09556 8 RKPTLDLPLEVQRKMWfkpfmQSYLVVFIGYLTMYLIRKNFKAAQNDMISTyGLSTTELGMIGLGFSITYGVGKTLVGYY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 87 SDRSNPRVFLPAGLILAAAVMLFMGFVPWATS-SIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAH 165
Cdd:PRK09556 88 ADGKNTKQFLPFLLILSAICMLGFGASLGSGSvSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISH 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 166 NVGGGIPPLLFLLGMAWFNDWHAA--LYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQ-ELTAK 242
Cdd:PRK09556 168 NLGGAGAGGVALWGANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETEStDMTKW 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 243 QIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfRGNRG 322
Cdd:PRK09556 248 QIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 323 ATGVFFMTLVTIATIVYwmNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 402
Cdd:PRK09556 327 LVACIALALIIFTLGVY--QHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFAKV 404
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 403 IVGYTVD------------FFGWDGGFMVMIGGSILAVILLIVVMIGEKR--RHEQLLQE 448
Cdd:PRK09556 405 GLGMIADptkngtpifgytLTGWAGTFAALDIAAIGCICLMAIVAVMEERkiRREKKIQQ 464
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
27-432 |
1.54e-85 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 266.19 E-value: 1.54e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMP-YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPaMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17488 81 INILFGF----SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFAFAMMRDTPQscglppieeykndypddynekaeqeltakqifmqyvlpnkLLWYIAIANVFV 265
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRPP----------------------------------------YIWLLAFCYVLV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAG 345
Cdd:cd17488 196 YVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVH 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 346 NPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGGSI 425
Cdd:cd17488 276 SYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAAL-AGYPLAKVIESWGWSGFFIVISIAAA 354
|
....*..
gi 729897337 426 LAVILLI 432
Cdd:cd17488 355 ISGLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-440 |
2.19e-70 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 227.06 E-value: 2.19e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 20 DPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPA 98
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 99 GLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLL 178
Cdd:COG2271 81 GLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 179 GMAWFnDWHAALYMPAFCAILVALFAFammrdtpqscglppieeykndypddynekaeqeltakqifmqyvlpnkllWYI 258
Cdd:COG2271 157 LLAAF-GWRAAFLILGLPGLLLALLRF--------------------------------------------------WLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 259 AIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRgATGVFFMTLVTIATIV 338
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-LVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 339 YWMnpAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFM 418
Cdd:COG2271 265 LAL--LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDATGYQAAFL 341
|
410 420
....*....|....*....|..
gi 729897337 419 VMIGGSILAVILLIVVMIGEKR 440
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
27-431 |
1.15e-54 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 187.54 E-value: 1.15e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMnELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLgMAWFND 185
Cdd:cd17343 81 TTVAFS----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATL-LALSYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNdyPDDYNEKAEQELTAKQifmqyVLPNKLLWYIAIANVFV 265
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEES--KGKKKKSPRGESTLKE-----LLLSPFLWLLSLGYLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDK-------VFRGN-RGATGVFFMTLVTIA-- 335
Cdd:cd17343 229 FGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWavakhgsSSRGNpRMPLALVFMAGLTVSlh 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 336 TIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFGWDG 415
Cdd:cd17343 309 LFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGG-VLAGLPFSYIAKHYDWRT 387
|
410
....*....|....*.
gi 729897337 416 GFMVMIGGSILAVILL 431
Cdd:cd17343 388 AFLLLEILCAITVVIL 403
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-432 |
1.18e-41 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 151.81 E-value: 1.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 34 IFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGF 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSfGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 113 VPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWF-NDWHAALY 191
Cdd:cd06174 81 AP----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 192 MPAFCAILVALFAFAMMRDTPQSCGLPpieeykndypddyneKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYG 271
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAK---------------NEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 272 ILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKvfrgNRGATGVFFMTLVTIATIVYWMNPAGNPTVDM 351
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----LIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 352 ICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILL 431
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 729897337 432 I 432
Cdd:cd06174 378 L 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-434 |
4.19e-35 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 133.46 E-value: 4.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDlGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFVpwatSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17319 81 FTALTGFA----TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFAFAMMRdtpqscglppieeykndypddynekaeqeltakqifmqyvlpnkLLWYIAIANVFV 265
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYLR--------------------------------------------QVWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIAtiVYWMNPAG 345
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVG--LLLAYLTT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 346 NPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFG-WDGGFMVMIGGS 424
Cdd:cd17319 270 SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV-APLLIGYLVDATGsYTAAFLFLAAVA 348
|
410
....*....|
gi 729897337 425 ILAVILLIVV 434
Cdd:cd17319 349 LLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-443 |
2.26e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 115.75 E-value: 2.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:COG2223 83 GLLLLALAV----SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFAFAMMRDTPqscglppieeykndyPDDYNEKAEQELTAKQIFMqyvlpNKLLWYIAIANVFV 265
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP---------------AGAAAAAKASLRDQLEALR-----DPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgnRGATGVFFMTLVTIATIVYWMNPAG 345
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 346 NPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFG-WDGGFMVMIGGS 424
Cdd:COG2223 294 SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLLFGALLDATGsYTAAFLVFAVLA 372
|
410
....*....|....*....
gi 729897337 425 ILAVILLIVVMIGEKRRHE 443
Cdd:COG2223 373 LVALVLTLLLYRRPRRAAA 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-400 |
6.66e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.28 E-value: 6.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 34 IFFGYAAYYLVRKNFALAMPYLV--EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMG 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 112 FvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALY 191
Cdd:pfam07690 81 F----ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 192 MPAFCAILVALFAFammrdtpqscglppieeYKNDYPDDYNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYG 271
Cdd:pfam07690 156 ILAILSLLAAVLLL-----------------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 272 ILDWSPTYLkEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIAtiVYWMNPAGNPTVDM 351
Cdd:pfam07690 219 LLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG--LLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 729897337 352 ICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-436 |
7.23e-28 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 113.87 E-value: 7.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 35 FFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV 113
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDlHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 114 pwatSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLfLLGMAWFNDWHAALYMP 193
Cdd:cd17475 82 ----GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL-LPPLALHYGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 194 AFCAILVALFAFAMMRDTPQSCGLPPieeykndypddyneKAEQELTAKQIfmqyVLPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:cd17475 157 GLVSILAAVLFWLFYREPPAASAATE--------------SASTLLRSLKE----VLRNRDVWLIAIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 274 DWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPT-VDMI 352
Cdd:cd17475 219 TFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLwLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 353 CMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFmvmiggSILAVILL 431
Cdd:cd17475 299 LLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDAtHSYAPAW------LALALLLV 371
|
....*
gi 729897337 432 IVVMI 436
Cdd:cd17475 372 LAALL 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-399 |
1.21e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.06 E-value: 1.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 21 PTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAG 99
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 100 LILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLg 179
Cdd:COG2814 82 LLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 180 MAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNdypddynekaeqeltakqifmqyVLPNKLLWYIA 259
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-----------------------LLRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 260 IANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIAtivy 339
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL---- 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 340 wMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVA 399
Cdd:COG2814 290 -LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-444 |
3.33e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 3.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLIL 102
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAfGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 103 AAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGrTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL--FLLGM 180
Cdd:COG0738 83 MALGLLLFALAP----SYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 181 AWFNDWHAALYMPAFCAILVALFAFAMmrdtpqscGLPPIEEykndypddynekAEQELTAKQIFMQYVLPNKLLWYIAI 260
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRS--------KLPEIEE------------EEEEAAGSAASLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 261 ANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTLVTIATIVYW 340
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLAL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 341 MnpAGNPTVDMICMIVIGFLIyGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVM 420
Cdd:COG0738 295 L--APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAI-GPPLIGFLADAFGLRAAFLVP 370
|
410 420
....*....|....*....|....
gi 729897337 421 IggsILAVILLIVVMIGEKRRHEQ 444
Cdd:COG0738 371 L---VCYLLILLLALALKRKRRKK 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
57-430 |
1.17e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 78.38 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGM 136
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 137 GwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFCAILVALFAFAMMRDTPQScg 216
Cdd:COG2807 123 G-NVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-GWRGALAVWALLALLALLLWLPLLRRRPAA-- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 217 lppieeykndypddyNEKAEQELTAKQifmqyVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYF 296
Cdd:COG2807 199 ---------------AAAAPAAASLRS-----LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 297 LYEYAGIPGTLLCGWMSDKVfrGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICM-IVIGFLIYGPVMLIGLHAlel 375
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFPLALTLIGLRA--- 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 729897337 376 APKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFG-WDGGFMVMIGGSILAVIL 430
Cdd:COG2807 333 RTPAEAAALSGMAQSVGYLLAALGP-LLVGALHDATGsWTAALLLLAALAVLMLVA 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-432 |
1.58e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.60 E-value: 1.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 52 MPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLC 130
Cdd:cd17478 19 LPLLIAKlGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP----NYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 131 GWFQGMGWPPcGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDwHAALYMPAFCAILVALFAFAMMRD 210
Cdd:cd17478 95 GIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG-LGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 211 TPQScglppieeykndyPDDYNEKAEQELTAKQIFmqyvlpnKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDK 290
Cdd:cd17478 173 KKPE-------------AKKAAAKSSARSTLKGVW-------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 291 SSWAYFLYEYAGIPGTLLCGWMSDkvfRGNRGATGVFFMTLVTIATIVYWMNPagnPTVDMICMIVIGFLIYGPVMLIGL 370
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSD---RFGRRRVIIASLLLAAPFLLLFLLTP---GIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 729897337 371 HALELAPKKaAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSILAVILLI 432
Cdd:cd17478 306 LAQELLPGN-VGLASGLMMGLSFGLGGIGA-PVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-433 |
2.99e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 30 IFLGIFFGYAAYYLVRKNFALampYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL---YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 110 MGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLgMAWFNDWHAA 189
Cdd:cd17325 78 FAFAT----SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 190 LYMPAFCAILVALFAFAMMRDTPQScglppieeykndypddyNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLR 269
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPP-----------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 270 YGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgnrGATGVFFMTLVTIATIVYWMNPAGNPTV 349
Cdd:cd17325 216 GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----GRKPLILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 350 DMICMIVIGFL--IYGPVMLigLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILA 427
Cdd:cd17325 291 LLLLLALLGLGlgLVFPATL--ALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367
|
....*.
gi 729897337 428 VILLIV 433
Cdd:cd17325 368 AVLFLL 373
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
27-438 |
3.23e-15 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 76.97 E-value: 3.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVRK-----------NFALAMPYLVEQGFSRGDLGFA----------LSGIS----IAYGFSKF 81
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKpisivksvlhpNCSALIPPPNIVLNNTTWCGWApfdgkngtelLGALDsaflFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 82 IMGSVSDRSNPRVFLPAGLILAAAVMLFMGF-VPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLgYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 161 WNcAHNVGGGIppLLFLLGMAWFN-DWHAALYMPAFCAILVALFAFAMMRDTPqscglPPIEEYkndypddynekaeqel 239
Cdd:cd17344 161 WN-SHTSVGNI--LGSLIAGIFVSsAWGLSFIVPGIIIAAMGVLVFLFLVEHP-----PGVIEF---------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 240 takqifmqyvlpnkllwyiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrG 319
Cdd:cd17344 217 -------------------SLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYT--G 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 320 NRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLI--------GLHALELAPKKAAGTAAGF---T 388
Cdd:cd17344 276 GRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALIttavsadlGTHKSLKGNARALATVTAIidgT 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 729897337 389 GLFGYLGGSVAASAIVGYtvdffGWDGGFMVMIGGSILAVILLIVVMIGE 438
Cdd:cd17344 356 GSIGAALGPLLAGLISSR-----GWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-432 |
3.51e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 76.96 E-value: 3.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIaEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 110 MGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAA 189
Cdd:cd17371 81 CGFAQ----NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 190 LYMPAFcAILVALFAFAMMRDTPQscglPPIeeykndypddYNEKAEQELTAKQIFMQYVLPNK------LLWyiAIANV 263
Cdd:cd17371 157 RVLFLL-GALPALLVLFIRRFVKE----PPQ----------WQAARAARRHFADRPSLRELFSPpllrttLLA--SLLAT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 264 FVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrGNRGATGVFFMtlVTIATIVYWMNP 343
Cdd:cd17371 220 GALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI--GRRNNFALFAL--GSAISILLYFFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 344 AGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGG 423
Cdd:cd17371 296 PLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGAL-FPFLVGFLATSGSLGTAIAVFAAV 374
|
....*....
gi 729897337 424 SILAVILLI 432
Cdd:cd17371 375 YYIAGLVLA 383
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
75-432 |
4.59e-15 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 76.58 E-value: 4.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMF--VLLFLCGWFQGMGWPPCGRTMVHWWSQK 152
Cdd:cd17342 75 SYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLycILWVLNGLLQSTGWPCVVAIMGNWFGKS 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 153 ERGGIVSVWNCAHNVGGGIPPLLflLGMAWFNDWHAALYMPAFCAILVALFAFammrdtpqsCGLPPIeeykndypddyn 232
Cdd:cd17342 155 SRGFVLGLWSACASVGNIIGALL--ASSVLDYGYEYAFLVTSSLLFAGAIVVF---------FGLLSS------------ 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 233 ekaeqeltakqifmqyvlPNKLLWYiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWM 312
Cdd:cd17342 212 ------------------PPGVIPY-SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 313 SDKVfrGNRGATGVFFMTLVTIATIVYWMNPaGNPTVDMICMIVIGFLIYGPVMLI--------GLHALELAPKKAAGTA 384
Cdd:cd17342 273 SDRM--GSRSPVVVVMLLLAIPSLFVYSHSP-SDKVLNAFVMTITGFFIGGPANLIssaisadlGRQPQLRGSSEALATV 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 729897337 385 AGFTGLFGYLGGSVaASAIVGYTVDFFGWDG---GFMVMIGGSILAVILLI 432
Cdd:cd17342 350 TGIIDGTGSIGAAI-GQVLVPLIQNRLGWMWvfyFFIIMTILTIVCILPLL 399
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-432 |
1.57e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.56 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAYYLVRKNFALAMPYLVE---QGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 108 LFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd17316 81 LLIGLLP----TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 188 AALYMPAFCAILvALFAFAMMRDTpqscglppieeykndypddynekaeqeltakqifmqyvlpnkllWYIAIANVFVYL 267
Cdd:cd17316 157 GWRILFLIGALP-ALLALLLRRRT--------------------------------------------LLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 268 LRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTLVTIATIVYWMNPAGNP 347
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 348 TVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILA 427
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
....*
gi 729897337 428 VILLI 432
Cdd:cd17316 349 LIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
31-448 |
2.17e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.94 E-value: 2.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAYYlvrknfALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-----VFLPAGLILAA 104
Cdd:COG2211 19 DLGLNLAFGLLS------AYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 105 AVMLFMGFVPWA--TSSIAVMFVLLFLCGWFQGMGWPPcgrtmvhWWS--------QKERGGIVSVWNCAHNVGGGIPPL 174
Cdd:COG2211 93 LSFVLLFTAPDLspTGKLIYALVTYLLLGLAYTLVNIP-------YSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 175 LFLLGMAWFND-----WHAALYMPAFCAILVALFAFAMMRDTPQscglppieeykndypddyneKAEQELTAKQIFmQYV 249
Cdd:COG2211 166 LPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFGTKERPV--------------------PEEEKVSLKESL-KAL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 250 LPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrGNRGATgVFFM 329
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAF-IIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 330 TLVTIATIVYWMNPAGNPTVDMICMIVIGFLiYGPVMLIGL--------HALELAPKKAAGTAAGFTGLFGYLGGSVAAs 401
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIG-LGAILVLPWamladvvdYDEWKTGRRREGLYFGIFTFAIKLGQALAG- 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 729897337 402 AIVGYTVDFFGWDGG-----------FMVMIGGSILAVILLIVVMIG---EKRRHEQLLQE 448
Cdd:COG2211 380 ALAGLLLALFGYVAGaaqspsaltgiRLLFFLLPAVLLLLAALLLLFyplTRERHAEIRAE 440
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
52-434 |
1.33e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.76 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 52 MPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLcg 131
Cdd:cd17355 27 IPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGG-- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 132 wFQGMGWPPCGRTMVHWWSQKERG---GIVSvwncahnVGGGIPPLLFLLGMAWFND---WHAALYMPAFCAILVALFAF 205
Cdd:cd17355 105 -GAGTLAAVAFATVAAWWFERRRGlalGILT-------AGGGLGSLVFLPLGAALIEafgWRTALLVLALLALLVLVPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 206 AMMRDTPQSCGLPpieeykndyPDDYNEKAEQELTAKQIFMqyvlpNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKH 285
Cdd:cd17355 177 LLLRRRPADLALR---------AYDDASPASPGSTLKEALR-----SASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 286 FALDKSSWAYFLYEYAGIPGTLLCGWMSDkvfRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMiVIGFLIYGPV 365
Cdd:cd17355 242 ISPAAAAVALALIGLFNIVGRLLSGWLGD---RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA-LFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 729897337 366 MLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAiVGYTVDFFGWDGGFMVMIGGSILAVILLIVV 434
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL-GGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
27-435 |
2.05e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 65.33 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMV---WPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGFVpwatSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL-FLLGMAWFN 184
Cdd:cd17329 78 GFALLGFA----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 185 D--WHAALYMPAFCAILVALFAFAMMRDTPQScGLPPIEEYKNdypddynekaeqeLTAKQIFMQYVLPNkLLWYIAIAN 262
Cdd:cd17329 154 LlfLAAAVLFLLAALVLLFLLPETRPKRRAAE-KTEILRGYKI-------------VLRDRAFLLFLLAS-FLISLIYFQ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 263 VFVYLlrygildwsPTYLKEVKHFALDKSSWayfLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMn 342
Cdd:cd17329 219 LESTL---------PVYVVEILGLGESLLGL---LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 343 pAGNPTVDMICMIV--IGFLIYGPVmlIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFGWDGGFMVM 420
Cdd:cd17329 286 -ANTLAVLILAMIVltLGEMLVFPA--VQTLVAALAPPDKRGSYMGFYALAWGLGR-AIGPLVGGLLLDLLGPGLPWLIL 361
|
410
....*....|....*
gi 729897337 421 IGGSILAVILLIVVM 435
Cdd:cd17329 362 AALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
66-433 |
3.48e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.41 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTM 145
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 146 vhwwSQKERGGIVSVWNCAhNVGGGI--PPLLFLLGMAWfnDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPpieey 223
Cdd:cd17324 117 ----PPEKRGRAIGLVFSG-LTLGLVlgRPLGGLLGQLL--GWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS----- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 224 kndypddYNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLlrygildwsPTYLKEVKHFALDKSSWAYFLYEYAGI 303
Cdd:cd17324 185 -------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYL---------APFLTDVPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 304 PGTLLCGWMSDKVFRGnrgaTGVFFMTLVTIATIVYWMNPAGNPTVDMIcMIVIGFLIYGPVMLIGLHALELAPkKAAGT 383
Cdd:cd17324 249 VGSPLAGRLADRGGRR----ALLIALLLLAAALLLLTLLGPSPLLLLVG-LVLWGLGFFAAHSALQTRVLRLAP-EARGL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 729897337 384 AAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGgfMVMIGGSILAVILLIV 433
Cdd:cd17324 323 ASSLYLAAYNLGGALGA-ALGGLVLDHGGWAG--VGWVGAALLLLALLLA 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-207 |
1.21e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.89 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 6 KPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGF--SRGDLGFALSGISIAYGFSKFIM 83
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYgiSPIIIGLLFAGWSVLLALGSLFV 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 84 GSVSD-RSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN 162
Cdd:cd17474 255 GRLLKkRFGARRILVIGLLLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 729897337 163 CAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFCAILVALFAFAM 207
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-209 |
1.31e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 1 MLSIFKPAPHKARLPAAEIDPTYRRLR-----WQIFLGIFFGYAAYYLVRKNFALAMPYLVeqGFSRGDLGFALSGISIA 75
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLrdrrlLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAQIGLLFGAQGLA 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 76 YGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERG 155
Cdd:cd17325 248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 729897337 156 GIVSVWNCAHNVGGGIPPLlfLLGMAWFNDWHAALYMPAFCAILVALFAFAMMR 209
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPL--LGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-419 |
6.74e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 57.65 E-value: 6.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGfvpWATSSIAVMFVLLFLCGwFQGMGW 138
Cdd:cd17341 30 GLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA---LAVSSYWGLLVLGFLLG-FAGANF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 139 PPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND------WHAALYMPAFCAILVALFAFAMMRDTP 212
Cdd:cd17341 106 ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFdggfvgWRNAFFVPGILLAIAAVLVLLFGDDLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 213 QScglppieeykndypddyneKAEQELTAKQIFmqYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSS 292
Cdd:cd17341 186 TG-------------------KASALEFLKVQL--AVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 293 WAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGF---LIYGPVMliG 369
Cdd:cd17341 245 ILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLgagAGNGSVF--R 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 729897337 370 LHALELapKKAAGTAAGFTGLFGYLGGSV------AASAIVGYTVDFFGWDGGFMV 419
Cdd:cd17341 323 MVPFIF--RRELGAVTGLVGAIGGLGGFFlpllfgSSALMTGSGVGAFSLFGVLAV 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-172 |
9.25e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 9.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 7 PAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 86 VSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAH 165
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
....*..
gi 729897337 166 NVGGGIP 172
Cdd:COG2814 342 FLGGPLA 348
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
59-406 |
1.17e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.60 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwATSSIAVMfVLLFLCGWFQGMGW 138
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL---ATNVTQLL-ILRFLAGLGLGGLM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 139 PPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFCAILVALFafaMMRDTPQSC--- 215
Cdd:TIGR00895 124 PNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-GWRSLFYVGGIAPLLLLLL---LMRFLPESIdfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 216 ---GLPPIEEYKNDYPDDYNEKAEQEL--------TAKQIFM-----QYVLPNKLLWYIAIANVFVYllrYGILDWSPTY 279
Cdd:TIGR00895 200 vskRPETVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKalfqgKTARITVLLWLLYFMLLVGV---YFLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 280 LKEVKhFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTLVTIATIVYWMnpAGNPTVDMICMIVIGF 359
Cdd:TIGR00895 277 MVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALLLLLGAVFAVLVGST--LFSPTLLLLLGAIAGF 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 729897337 360 LIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGY 406
Cdd:TIGR00895 351 FVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP-ILAGY 396
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-211 |
3.23e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 55.26 E-value: 3.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 6 KPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2807 196 PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAV---VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 86 VSDRSNPRvflpAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGmGWPPCGRTMV--HWWSQKERGGIVSVWNC 163
Cdd:COG2807 273 LADRLGDR----RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLIglRARTPAEAAALSGMAQS 347
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 729897337 164 AHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDT 211
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
98-433 |
2.67e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.32 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 98 AGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFL 177
Cdd:cd17333 62 RTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 178 LGMAWFNDWHAALYMPAFCAILVALFAFammrdtpqsCGLPPIEEYKNDYPddynekaeQELTAKQIFMQYVLPNKLLWY 257
Cdd:cd17333 141 SLLTSELSWSWAYLIIGLIYLLLAILIL---------LTLFPELPSARNPQ--------QSVGAFSASASRLLRNPSIIL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 258 IAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgnRGATGVFFMTLVTIA-T 336
Cdd:cd17333 204 GALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI----KPHTLLVLSGSGALLgL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 337 IVYWMNPagNPTVDMICMIVIGFLIyGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGG 416
Cdd:cd17333 280 LILLLAP--TLVVGLVATALLGLFM-AALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAI-IPFIMGFIAEAVGIQTA 355
|
330
....*....|....*..
gi 729897337 417 FMVMIGGSILAVILLIV 433
Cdd:cd17333 356 MLLITILYAIIFVLALL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-435 |
2.50e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 30 IFLGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17489 1 ILLANFFFFLSFYLL---LPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 110 MGFVPwatsSIAVMFVLLFLcgwfQGMGW---PPCGRTMVHWWSQKERGGIVSVWN-CAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17489 78 YLLAT----SVALLLVLRLI----HGIGWgafTTAAATLVADIIPPSRRGEGIGYYgLATTLAMALGPALGLFLYQHLG- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 wHAALYMPAFCAILVALFAFAMMRDTPQScglppieeykndypddyneKAEQELTAKQIFMQYVlpNKLLWYIAIANVFV 265
Cdd:cd17489 149 -FAVLFIVAAVLALLALLLVFLVKDPPPV-------------------AAEEAEAGTRAFRRLV--EKKVLPPALILFLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVKHfaldkSSWAYFLYEYAGipGTLLCGWMSDKVF-RGNRGATGVFFMTLVTIATIVYWMnpA 344
Cdd:cd17489 207 SIAYGAISTFLPLYAAERGI-----SNAGLFFTVYAI--ALLLSRPFSGKLSdRKGPKTVIIPGLLLLALGLLLLSF--A 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 345 GNPTVDMICMIVIGfLIYGPVML-IGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFmvmIGG 423
Cdd:cd17489 278 GSPWMLLLAAVLYG-LGFGLLFPaLQALAVDLVPPHRRGAANGTFFIFFDLGIGL-GGLLLGLVAELFGYRAMF---LLA 352
|
410
....*....|..
gi 729897337 424 SILAVILLIVVM 435
Cdd:cd17489 353 AVVVLLALVLYI 364
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
27-434 |
2.56e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.53 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 27 RWQIFLGiFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGlilaaA 105
Cdd:cd17353 2 RWLVLLG-AVLMHLILGYQYAWSVFNPPLSSAlGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIG-----G 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 106 VMLFMGfvpWATSSIAVMFVLLFLCGWF-----QGMGWPPCGRTMVHWWSQKeRGGIVSVWNCAHNVGGGIPPLLFLLGM 180
Cdd:cd17353 76 ILFGLG---FILSAFAISLPLLFLGYGVlggigAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 181 AWFNDWHAALYMPAFCAILVALFAFaMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMqyvlpnkLLWYIAI 260
Cdd:cd17353 152 NTVGVPTTFLILGIIFLIIIVIGAF-LIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFW-------LLWLMFF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 261 ANVFVYLLRYGIldwSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgNRGATGVFFMTLVTIATIVYW 340
Cdd:cd17353 224 LNATAGLMLIGQ---AKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGR-KNTLSIAFLIQGVAMFLLPFI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 341 mnpAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTgLFGYLGGSVAASAIVGYTVDFFGWDGGFMVM 420
Cdd:cd17353 300 ---GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA 375
|
410
....*....|....
gi 729897337 421 IGGSILAVILLIVV 434
Cdd:cd17353 376 AALSLVALALALLL 389
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
57-435 |
3.36e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.74 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGM 136
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF----AQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 137 GWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFCAILVALFAFAMMrdtpqscg 216
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFLLGGVPPLILLPLLRGTL-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 217 lppieeykndypddynekaeqeltakqifmqyvlpnkLLWYIAIANVFVYllrYGILDWSPTYLKEVKhFALDKSSWAYF 296
Cdd:cd17365 175 -------------------------------------LLWVTFFMGLLLV---YLLNSWLPKLMVEAG-YSLSQALTITL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 297 LYEYAGIPGTLLCGWMSDKvFRGNRGATGVFFMTLVTIATIVYWMNPagnPTVDMICMIVIGFLIYGPVMLIGLHALELA 376
Cdd:cd17365 214 LLNIGGVIGSLLLGWLADR-FGPKRVLALFFALGAVSLALLGVSPAS---LVLLYVLVFLAGACVNGAQVGLYALAARFY 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 377 PKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFMVMIGGSILAVILLIVVM 435
Cdd:cd17365 290 PTEVRATGVGWALGVGRL-GAILGPLLGGLLLAAgLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-314 |
3.96e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAyylvRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLF 109
Cdd:cd17380 5 FLATCICYAD----RVNMPIAIVPMAkEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 110 MGFVPWatSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVG----GGIPPLLfllgMAWFNd 185
Cdd:cd17380 81 TPLLAY--SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGtllgGLIGPLL----LEYYG- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 186 WHAALYMPAFCAILVALFafammrdtpqscglppieeykndypddynekaeqeltakqiFMQYVLPnklLWYIAIANVFV 265
Cdd:cd17380 154 WPSVFYFFGLLGLLWALV-----------------------------------------WLIYLPP---VWAIIVAHFCM 189
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 729897337 266 YLLRYGILDWSPTYLKEVkhFALDKSSWAYFLYEY-AGIPGTLLCGWMSD 314
Cdd:cd17380 190 NWGFYILLSWLPTYFHEV--LVPLAKGWVFNVVPWlVMFPSSNVAGWLAD 237
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
59-212 |
7.08e-06 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 48.38 E-value: 7.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 59 GFSRGDLGFAlsGISIAYG--FSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFlcgwfqgm 136
Cdd:PLN00028 67 NLTKSDIGNA--GIASVSGsiFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGF-------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 137 gwppCGRTMV---HWWSQKERGGIVSVWN-CAH---NVGGG----IPPLLFLLGMAWFND----WHAALYMPAFCAILVA 201
Cdd:PLN00028 137 ----SLATFVscqYWMSTMFNGKIVGTANgIAAgwgNLGGGvtqlLMPLVFPLIKDAGAPsftaWRIAFFVPGLLHIIMG 212
|
170
....*....|.
gi 729897337 202 LFAFAMMRDTP 212
Cdd:PLN00028 213 ILVLTLGQDLP 223
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-205 |
1.02e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 28 WQIFLGIFFGYAAYYLVrkNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDR-SNPRVFLPAGLILAAAV 106
Cdd:cd06174 206 WLLLLAIFLVNLAYYSF--STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 107 MLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMvhwwSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDW 186
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
170
....*....|....*....
gi 729897337 187 HAALYMPAFCAILVALFAF 205
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-207 |
1.27e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 1 MLSIFKPAPHK---ARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVrknfALAMPYLVE--QGFSRGDLGFALSGISIA 75
Cdd:cd17473 170 LLFLPEPARKSksaASPGAATAAALPWKRVLPIYFLAFLAMLLFYVI----PIQLPFLLQerGGGSAALIGLALAIASLA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 76 YGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPpcgrTMVHWWSQ---- 151
Cdd:cd17473 246 GAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL----ASGLWVVLLGAILAGLGFGLLLP----TLNSWAMSlvpp 317
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 729897337 152 KERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAM 207
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
4-203 |
1.30e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.14 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 4 IFKPAPHKARLPAAEIDPTYRRLRWQIFLGIF--FGYAAYYLVRKNFALAmpYLVEQ-GFSRGDLGFALSGISIAYGFSK 80
Cdd:cd17369 204 VFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGlrLAENVLFYLFTTFALS--YATQTlGVDRSTVLLAVLIASVVAAITI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:cd17369 282 PLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASL 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 729897337 161 -WNCAHNVGGGIPPLLFLLGMAWFNDWHA-ALYMPAFCAI-LVALF 203
Cdd:cd17369 362 gYQLGAILGGGFAPLIATALVAATGSWWPvALYLAALAVIsLVAAL 407
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-207 |
2.05e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 30 IFLGIFFGYAAYYLVrknfalAMPYLVEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:cd06173 215 LALALFALLGGALTV------LLPLLAKEvlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 108 LFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNcahNVGGGIPPLLFLLG--MAWFND 185
Cdd:cd06173 289 LVLGLSP----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN---ALNSGAMPLGALLAglLADALG 361
|
170 180
....*....|....*....|..
gi 729897337 186 WHAALYMPAFCAILVALFAFAM 207
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
7-206 |
2.11e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.50 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 7 PAPHKARLPAAEIDPTY-------RRLRWQIFLGIFFGYAAYYLVRKNFalaMPYLVEQGFSRGDLGFALSGISIAYGFS 79
Cdd:cd17355 185 DLALRAYDDASPASPGStlkealrSASFWLLALAFFLCGFAVVGLIVHL---VPYLADRGISPAAAAVALALIGLFNIVG 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 80 KFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWaTSSIAVMFVLLFLCGWFQGMgwPPCGRTMVHWWSQKERGGIVS 159
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPF-PPLALLLFAALFGLGWGATV--PLTAALAARYFGARSYGTLFG 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 729897337 160 VWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFA 206
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-207 |
2.28e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 17 AEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVF 95
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADlGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 96 LPAGLILAAAVMLFMGFVPwatsSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL 175
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190
....*....|....*....|....*....|..
gi 729897337 176 FLLGMAWFnDWHAALYMPAFCAILVALFAFAM 207
Cdd:COG0477 158 GGLLVAAL-GWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-171 |
2.41e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 32 LGIFFGYAAYYLVrkNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMG 111
Cdd:cd17321 175 LAAFLLGAALGGL--LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLA 252
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 112 FVPwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI 171
Cdd:cd17321 253 LLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-207 |
3.30e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 28 WQIFLGIFFGYAAYYLVrknFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAV 106
Cdd:cd17324 201 RLAYLITFLLFGGFFAL---YTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 107 MLFMGFVPWatssIAVMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFllGMAWfnDW 186
Cdd:cd17324 278 LLLTLLGPS----PLLLLVGLVLWGLGFFAA-HSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALG--GLVL--DH 348
|
170 180
....*....|....*....|.
gi 729897337 187 HAALYMPAFCAILVALFAFAM 207
Cdd:cd17324 349 GGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
258-434 |
5.60e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 5.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 258 IAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgnrGATGVFFMTLVTIATI 337
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 338 VYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGF 417
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAF 154
|
170
....*....|....*..
gi 729897337 418 MVMIGGSILAVILLIVV 434
Cdd:pfam07690 155 LILAILSLLAAVLLLLP 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
251-435 |
6.01e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 251 PNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVkHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMT 330
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 331 LVTIATIVYWMnpAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDF 410
Cdd:COG2814 84 LFALGSLLCAL--APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP-LLGGLLADL 160
|
170 180
....*....|....*....|....*
gi 729897337 411 FGWDGGFMVMIGGSILAVILLIVVM 435
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-205 |
9.55e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 9.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 24 RRLRWQIFLGIFFGYAAYYLvrknFALAMPYLVEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYG----LTTFLPTYLQTvlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 102 LAAAVMLFMGFvpWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERG-GIVSVWNCAHNVGGGIPPLLFLLgM 180
Cdd:cd17316 252 LSGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAtGVGLSYNLGRLGGGGAPPLIALL-L 328
|
170 180
....*....|....*....|....*
gi 729897337 181 AWFNDWHAALYMPAFCAILVALFAF 205
Cdd:cd17316 329 ASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-433 |
1.23e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 28 WQIFLGIFFGYAAYYLVRknFALAMpYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-VFLPAGLILAAAV 106
Cdd:cd06173 2 RLLWLAQLLSALGDWIFT--VALPW-LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrLLILADLLRALLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 107 MLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdW 186
Cdd:cd06173 79 AVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-P 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 187 HAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEykndypddynekaeqeLTAKQIFMQYVLPNKLLWYIAIANVFVY 266
Cdd:cd06173 158 GGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL----------------LRDLREGLRYLRRSPLLRLLLLALALFA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 267 LLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTLVTIATIVYWMNPagN 346
Cdd:cd06173 222 LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLLGLALLVLGLSP--S 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 347 PTVDMICMIVIGFLIygPVMLIGLHAL--ELAPKKAAGTAAGFTGLFGYlGGSVAASAIVGYTVDFFGWDGGFMVMIGGS 424
Cdd:cd06173 297 LWLLLAALFLLGLAG--GLFNVPLNTLlqLRVPDELRGRVFSVYNALNS-GAMPLGALLAGLLADALGLSAVFLLAGALL 373
|
....*....
gi 729897337 425 ILAVILLIV 433
Cdd:cd06173 374 LLAALLLLL 382
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
31-396 |
1.52e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.83 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAYYLvrknFALAMPYLVEQGF--SRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVML 108
Cdd:TIGR00886 7 WFGFFLSFLVWFA----FSPLAVFLIKDDLglSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 109 FMGFvpwATSSIAVMFVLLFLCGwFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI-----PPL----LFLLG 179
Cdd:TIGR00886 83 WAGL---AVQSYSVLLLIRLFIG-IAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVaqfvmPPIigslIFGGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 180 MAWFNDWHAALYM-PAFCAILVALFAFAMMRDTPqscglppieeykndyPDDYNEKAEQELTAKQIFMQYVLPNKLLWYI 258
Cdd:TIGR00886 159 QPAHLAWGWAFVIvPAGILLLPALLIFFVGADTP---------------PGKPATGKLSFKEALKVFGNRHTWILALLYS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 259 AIANVFVyllryGILDWSPTYLKEVkhFALDKSSWAY--FLYEYAGIPGTLLCGWMSDKVfrGNRGATGVFFMTLVTIAT 336
Cdd:TIGR00886 224 VTFGSFL-----GVSSIFAMLFKDQ--FGLSKVQAGAyaSLGGFLGSLARPAGGAISDRL--GGARKLLMNFLGVAMGAF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 337 IVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGG 396
Cdd:TIGR00886 295 LVVLGLVSDGSLAAFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-430 |
2.42e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.99 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAavmLFMGFVPWATS-SIAVMFVLLFLCGWFQGMGWPPCGRT 144
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITA---LLTLLTPLAARgGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 145 MVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFCAILVALFafammrdtpqscglppieeyk 224
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG-WPSIFYIFGGLGLLWCLL--------------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 225 ndypddynekaeqeltakqiFMQYVLPnklLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDK----SSWAYFlyey 300
Cdd:cd17318 194 --------------------WFFLVLP---VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSngflSSLPYL---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 301 AGIPGTLLCGWMSDK-VFRGNRGATGV--FFMTLVTIativywmnpagnptVDMICMIVIGFLIYGPVMLI-------GL 370
Cdd:cd17318 247 AMWICSIVGGYLADWlRSRGILSTTTVrkLFTSIGFL--------------GPGVFLIALGYLGSNATLAVvfltlsvGL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729897337 371 HA----------LELAPKkAAGTAAGFTGLFGYLGGSVaASAIVGYTV----DFFGWDGGFMVMIGGSILAVIL 430
Cdd:cd17318 313 SGacysgflvnhLDLAPN-YAGTLMGITNTAATIAGII-SPLIVGAIVkndqTIGQWRIVFFISAAIYILGAIF 384
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
65-288 |
7.92e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 41.65 E-value: 7.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAavmLFMGFVPWATssiAVMFVLLFLCGWFQGMGWPPCGRT 144
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSS---VISIVIPWAA---GGGIALVVFCRVIQGLAQGSVSPA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 145 MVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND----WHAALYMPAFCAILVALFAFAMMRDTPQS--CGLP 218
Cdd:TIGR00894 152 THKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEswggWPMIFYVFGIVGCAWSLLWFVFPADDPSIhpCISK 231
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 729897337 219 PIEEYKNDYPDDYNEKAEQELTAKQIfmqyvlPNKLLWYIAIANVFVYLLRYGIL-DWSPTYLKEVKHFAL 288
Cdd:TIGR00894 232 FEKKYINSSLQGQKGSTRQSLPIKAI------PKSLPVWAIWFAIFGHFWLYTILpTYLPTFISWVLRVSG 296
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
49-405 |
1.05e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 49 ALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPwatsSIAVMFVLL 127
Cdd:cd17321 16 NVALPTIARDlGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP----SLAFLIAAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 128 FLcgwfQGMG---WPPCG-RTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL--FLLgmaWFNDWHAALYMPAFCAILVA 201
Cdd:cd17321 92 AL----QGIGaaaIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLggLLL---ELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 202 LFAfammrdtpqscglppieeykndypddynekaeqeltakqifmqyvlpnKLLWYIAIANVFVYLLRYGILDWSPTYLK 281
Cdd:cd17321 165 LLA------------------------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 282 EVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrGNRGATGV-FFMTLVTIATIVYWMNPAGNPTVdMICMIVIGF- 359
Cdd:cd17321 197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF--GPRLVLVAgLLLTAVGLLLLALLGADSSVWLL-LPGLVLLGLg 273
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 729897337 360 --LIYGPVMLIglhALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVG 405
Cdd:cd17321 274 lgLFATPLTNA---ALSSVPKEKAGAASGILNTARQLGGALGV-ALLG 317
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-436 |
1.40e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.64 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 51 AMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAvmlfMGFVPWATSSIAVMFVLLFL 129
Cdd:cd17320 21 ALPAIARDlGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFIL----ASLLCALASSIEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 130 cgwfQGMGWPPC---GRTMVH-WWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFCAILVALFAF 205
Cdd:cd17320 97 ----QGLGAAAGsvvARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWRAIFVFLALLGLLLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 206 AMMRDTPQScglppieeykndypddynEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKH 285
Cdd:cd17320 172 LFLPETLPE------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 286 FALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN--RGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYG 363
Cdd:cd17320 234 LSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIF 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729897337 364 PVMLIGlhALELAPKkAAGTAAGFTGLFGYLGGSVAASAIVgytvdfFGWDGGFMVMIGGSILAVILLIVVMI 436
Cdd:cd17320 314 PNATSL--ALEPFPH-VAGTASALLGFLQFLIGALAGALVG------LLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
30-205 |
1.74e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 30 IFLGIFFGYAAYYLVrknFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVF-LPAGLILAAAVML 108
Cdd:cd17352 188 LALGVSFAMLGFFVP---FVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLyLYIFTLLILGLSL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 109 FMGFVPWATSSIAVMFVLLFLC-GWFQGMgWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGgiPPLLFLLgMAWFNDWH 187
Cdd:cd17352 265 LAFPLATTYVGLIVFSVLFGFCsGSYSSL-TPVILADLVGLEKLSNAYGLVLLFQGLAALVG--PPIAGLL-RDYTGDYD 340
|
170
....*....|....*...
gi 729897337 188 AALYMPAFCAILVALFAF 205
Cdd:cd17352 341 AAFYFCGACLLLSGVLLF 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
252-432 |
2.75e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 252 NKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRgatgVFFMTL 331
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARR----ILVIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 332 VTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIvGYTVDFF 411
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLF-GLLLEIF 351
|
170 180
....*....|....*....|.
gi 729897337 412 GWDGGFMVMIGGSILAVILLI 432
Cdd:cd17474 352 GLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-203 |
2.86e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 31 FLGIFFGYAAYYLVRKNFALAMP-----YLVEQGFSRGDLGFALSGISIAYGFSKFIMGS-VSDRSNPR-----VFLPAG 99
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPtfflrAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGiLADRLRRKtpradPLVCAV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 100 LILAAAVMLFMGFVpWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN-CAHNVGGGIPPLLFLL 178
Cdd:cd17328 289 GLLAAAPFLFLALV-LALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIlLSHLLGDAGSPYLIGL 367
|
170 180 190
....*....|....*....|....*....|....*.
gi 729897337 179 -----------GMAWFNDWHAALYMPAFCAILVALF 203
Cdd:cd17328 368 isdllrqnkdsPLAEAASLQYALLLCSFVLVLGGFF 403
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-183 |
3.11e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 28 WQIFLGIFFGYAAYYLvrknfalampylveqGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVM 107
Cdd:COG2211 244 LALVAALLLYYFKYVL---------------GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 108 LFMGFVPWatSSIAVMFVLLFLCGWFQGMGWpPCGRTMV-------HWWSQKERGGIV-SVWNCAHNVGGGIPPLLFLLG 179
Cdd:COG2211 309 LLLFFLGP--GNLWLLLVLAALAGIGLGAIL-VLPWAMLadvvdydEWKTGRRREGLYfGIFTFAIKLGQALAGALAGLL 385
|
....
gi 729897337 180 MAWF 183
Cdd:COG2211 386 LALF 389
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
32-430 |
3.20e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 32 LGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFM 110
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRlGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 111 GFVPWAtssiAVMFVLLFLCGWFQGMgwppCGRTMVHWWSQKERGGIVSVWNCAH---NVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd17393 82 GLAPSV----PALALALFLFGAANGA----LDVAMNAQGVAVERAYGRPIMSSLHamwSLGGLAGALLGAAAIGAGVSPG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 188 AALYMPAFCAILVALFAF-AMMRDTPQSCGlppieeykndypddynekAEQELTAKQIFmqyVLPNKLLWYIAIANVFVY 266
Cdd:cd17393 154 VHLLAAAVLLLLAALVAIrALLPGTGEAAE------------------DRPDGAGKPGF---LLPNRLLLLLGLLALAAA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 267 LLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTLVTIATIVYWMnpAGN 346
Cdd:cd17393 213 LAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRF---GDVAVLRAGALLAALGLLLALL--APS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 347 PTVDMICMIVIGFLIYGPVMLIgLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSIL 426
Cdd:cd17393 288 VWVALAGFALMGLGLSVVVPLA-FSAAGALPGLAAGIAVARVATLGYL-GFLVGPPLIGFLADATGLRTAFLVVALLALL 365
|
....
gi 729897337 427 AVIL 430
Cdd:cd17393 366 VALL 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
5-204 |
3.53e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 5 FKPAPHKARLPAAEIDPtyRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMG 84
Cdd:cd17477 167 LTRRAAPEIEEAESISL--RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 85 SVSDRSNPRVFLpagLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCA 164
Cdd:cd17477 245 WLADRFDRRRVL---LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLL 321
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 729897337 165 HNVGGGIPPLLFLLGMAWFNDwHAALYMPAFCAILVALFA 204
Cdd:cd17477 322 YGLGSVIGPLLAGALMDAFGP-HGLFLFLAAVALLFLLFL 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
84-205 |
3.57e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.54 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 84 GSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLC-GWFQGMGwppCGRT--MVHWWSQKERGGIVSV 160
Cdd:cd17341 262 GWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVAlGLGAGAG---NGSVfrMVPFIFRRELGAVTGL 338
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 729897337 161 WNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAF 205
Cdd:cd17341 339 VGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
93-431 |
5.72e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 93 RVFLPAGLILAAAVMLFMgfvpwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIP 172
Cdd:cd17477 62 RAFAAGAAITAVSVLLLA-----LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 173 PLLfllgMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPqscglPPIEEykndypddynekaEQELTAKQIFMQYVLpn 252
Cdd:cd17477 137 PLL----LALVGTAGALPFLIAAVLLLLALVPLLLTRRAA-----PEIEE-------------AESISLRRLLRIAPL-- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 253 kllwyiAIANVFVY-LLRYGILDWSPTYLKEVkHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfrgNRGATGVFFMTL 331
Cdd:cd17477 193 ------ALLGAFVAgFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRF---DRRRVLLGCALL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 332 VTIATIVYWMnPAGNPTVDMICMIVIGFLIYG--PVMLIglHALELAPKKAAGTAAGFTGLFgYLGGSVAASAIVGYTVD 409
Cdd:cd17477 263 GALAALLLPL-VPGLPLALLVLLFLWGGAAGPlyTLALA--LAGDRLPGDELVAANAALLLL-YGLGSVIGPLLAGALMD 338
|
330 340
....*....|....*....|..
gi 729897337 410 FFGWDGGFMVMIGGSILAVILL 431
Cdd:cd17477 339 AFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
255-435 |
6.53e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 255 LWYIAIANVFVYLLRYGILdwspTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTI 334
Cdd:cd06174 1 LLLGFFLTGLARGLISPLL----PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 335 ATIVywmnpAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA-SAIVGYTVDFFGW 413
Cdd:cd06174 77 LFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPlLGGILASSLGFGW 151
|
170 180
....*....|....*....|..
gi 729897337 414 DGGFMVMIGGSILAVILLIVVM 435
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVV 173
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
152-412 |
7.27e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 7.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 152 KERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQScglpPIEEYKNDYPDDY 231
Cdd:cd17328 119 EKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRG----AAEGGVMAKSTAT 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 232 NEKAEqeltakqifMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLK---EVKHFALDKSSWAYFLYE-YAGIPGTL 307
Cdd:cd17328 195 SFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLrafGVGDLSSADVGLIFGAITcIAGVLGVL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 308 LCGWMSDKVFRGNRGA---TGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTA 384
Cdd:cd17328 266 LGGILADRLRRKTPRAdplVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTA 345
|
250 260
....*....|....*....|....*...
gi 729897337 385 AGFTGLFGYLGGSVAASAIVGYTVDFFG 412
Cdd:cd17328 346 SAIQILLSHLLGDAGSPYLIGLISDLLR 373
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-171 |
7.65e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 7.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729897337 32 LGIFFGYAAYYLVrknFALAMPYLVE-QGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFM 110
Cdd:cd17503 185 LLSFLLGLGLFGA---MFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLL 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 729897337 111 GFVPwATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI 171
Cdd:cd17503 262 AFLT-PDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSI 321
|
|
| |
