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Conserved domains on  [gi|728872487|gb|AIY83148|]
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glycosyl transferases group 1 family protein [Clostridium baratii str. Sullivan]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-378 2.93e-39

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 143.45  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   2 KIMHICSYYP-----SSKLYENLLDKLNNENVDNTVYIPCKPSSVEKIKRSSKNSKFIISPIFLEGKN-LLEKFKNCSER 75
Cdd:cd03801    1 KILLLSPELPppvggAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARrLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  76 ALFykhneilyyDLidkinvinyecVHAHSLFSnGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHLKKV---GIEIMK 152
Cdd:cd03801   81 RKF---------DV-----------VHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLlarAEALLR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 153 NAKKIIFISKSYKEYVlnnilnEKNRELLNEKMIVIPNGIDDYWLYNSYNSKSKNIGKKINMIQVGRLNKNKNILTSIKV 232
Cdd:cd03801  140 RADAVIAVSEALRDEL------RALGGIPPEKIVVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEA 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 233 CDNLKAKGMNINLKIIG-EGPIKTKLEKKIINKNYI-KIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLP 310
Cdd:cd03801  214 LAKLLRRGPDVRLVIVGgDGPLRAELEELELGLGDRvRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLP 293

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728872487 311 VIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEK-SRDFDWSKIAKIYKEIY 378
Cdd:cd03801  294 VVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADpelRARLGRAARERvAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-378 2.93e-39

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 143.45  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   2 KIMHICSYYP-----SSKLYENLLDKLNNENVDNTVYIPCKPSSVEKIKRSSKNSKFIISPIFLEGKN-LLEKFKNCSER 75
Cdd:cd03801    1 KILLLSPELPppvggAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARrLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  76 ALFykhneilyyDLidkinvinyecVHAHSLFSnGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHLKKV---GIEIMK 152
Cdd:cd03801   81 RKF---------DV-----------VHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLlarAEALLR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 153 NAKKIIFISKSYKEYVlnnilnEKNRELLNEKMIVIPNGIDDYWLYNSYNSKSKNIGKKINMIQVGRLNKNKNILTSIKV 232
Cdd:cd03801  140 RADAVIAVSEALRDEL------RALGGIPPEKIVVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEA 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 233 CDNLKAKGMNINLKIIG-EGPIKTKLEKKIINKNYI-KIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLP 310
Cdd:cd03801  214 LAKLLRRGPDVRLVIVGgDGPLRAELEELELGLGDRvRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLP 293

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728872487 311 VIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEK-SRDFDWSKIAKIYKEIY 378
Cdd:cd03801  294 VVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADpelRARLGRAARERvAERFSWERVAERLLDLY 365
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 210-365 5.80e-21

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 88.49  E-value: 5.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  210 KKINMIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKNYIKI---IGNLSKEKLKDEYDGSH 286
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNvifLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 728872487  287 IFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDNySEMSKNAIEKSRDF 365
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLED-EELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 271-378 9.89e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 81.19  E-value: 9.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 271 GNLSKEK-----LKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNIL 345
Cdd:COG0438    2 GRLVPRKgldllLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 728872487 346 MIIDNYS---EMSKNAIEKSRD-FDWSKIAKIYKEIY 378
Cdd:COG0438   82 RLLEDPElrrRLGEAARERAEErFSWEAIAERLLALY 118
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 214-367 3.37e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 67.43  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 214 MIQVGRLNKNKNILTSIKVCDNLKakgmNINLKIIGEGPIKTKLEKKIINKNYIKIiGNLSKEKLKDEYDGSHIFIMPSK 293
Cdd:PLN02871 266 IVYVGRLGAEKNLDFLKRVMERLP----GARLAFVGDGPYREELEKMFAGTPTVFT-GMLQGDELSQAYASGDVFVMPSE 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 294 KETFGLVYPEAMSRGLPVIYTRNQGFDKFF---EEGYIGF---SAKYNDELEIEKNILMIIDNYSEMSKNAIEKSRDFDW 367
Cdd:PLN02871 341 SETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTGFlytPGDVDDCVEKLETLLADPELRERMGAAAREEVEKWDW 420
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 282-317 3.27e-03

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 39.30  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 728872487  282 YDGSHIFIMPSKKETFGLVYPEAMSRGLPVIyTRNQ 317
Cdd:TIGR04047 274 YRCADAFAFPSLKEGFGLVVLEALASGIPVV-ASDI 308
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-378 2.93e-39

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 143.45  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   2 KIMHICSYYP-----SSKLYENLLDKLNNENVDNTVYIPCKPSSVEKIKRSSKNSKFIISPIFLEGKN-LLEKFKNCSER 75
Cdd:cd03801    1 KILLLSPELPppvggAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARrLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  76 ALFykhneilyyDLidkinvinyecVHAHSLFSnGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHLKKV---GIEIMK 152
Cdd:cd03801   81 RKF---------DV-----------VHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLlarAEALLR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 153 NAKKIIFISKSYKEYVlnnilnEKNRELLNEKMIVIPNGIDDYWLYNSYNSKSKNIGKKINMIQVGRLNKNKNILTSIKV 232
Cdd:cd03801  140 RADAVIAVSEALRDEL------RALGGIPPEKIVVIPNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEA 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 233 CDNLKAKGMNINLKIIG-EGPIKTKLEKKIINKNYI-KIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLP 310
Cdd:cd03801  214 LAKLLRRGPDVRLVIVGgDGPLRAELEELELGLGDRvRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLP 293

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728872487 311 VIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEK-SRDFDWSKIAKIYKEIY 378
Cdd:cd03801  294 VVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADpelRARLGRAARERvAERFSWERVAERLLDLY 365
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 87-377 2.12e-28

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 113.91  E-value: 2.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  87 YDLIDKINVINYECVHAHSLFSNGYLAYKLRKNYGLEyIVAVRNTDINYFFKYMKHLKKVGIeimknaKKIIFISKSYKE 166
Cdd:cd03817   74 KAVIDRIKELGPDIIHTHTPFSLGKLGLRIARKLKIP-IVHTYHTMYEDYLHYIPKGKLLVK------AVVRKLVRRFYN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 167 YVLNNI-LNEKNRELLNE-----KMIVIPNGIDDYWLYNSYNSKSKNIGKKIN----MIQVGRLNKNKNILTSIKVCDNL 236
Cdd:cd03817  147 HTDAVIaPSEKIKDTLREygvkgPIEVIPNGIDLDKFEKPLNTEERRKLGLPPdepiLLYVGRLAKEKNIDFLLRAFAEL 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 237 KAKgMNINLKIIGEGPIKTKLEKKIINKNYIKI---IGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIY 313
Cdd:cd03817  227 KKE-PNIKLVIVGDGPEREELKELARELGLADKvifTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVA 305

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 728872487 314 TRNQGFDKFFEEGYIGF-SAKYNDELEIE-KNILMIIDNYSEMSKNAIEKSRDFDWSK-IAKIYKEI 377
Cdd:cd03817  306 AKDPAASELVEDGENGFlFEPNDETLAEKlLHLRENLELLRKLSKNAEISAREFAFAKsVEKLYEEV 372
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 3-378 5.69e-27

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 110.16  E-value: 5.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   3 IMHICSYYPSSKLYE------NLLDKLNNENVDNTV--YIPCKPSSVEKIKRSSKNSKFIISPIFLEGKNL---LEKFKN 71
Cdd:cd03798    1 VLILTNIYPNANSPGrgifvrRQVRALSRRGVDVEVlaPAPWGPAAARLLRKLLGEAVPPRDGRRLLPLKPrlrLLAPLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  72 CSERALFYKHNEILYYDLIdkinvinyecvHAHSLFSNGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHlKKVGIEIM 151
Cdd:cd03798   81 APSLAKLLKRRRRGPPDLI-----------HAHFAYPAGFAAALLARLYGVPYVVTEHGSDINVFPPRSLL-RKLLRWAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 152 KNAKKIIFISKSYKEyVLNNILNEKNREllnekmIVIPNGID-------DYWLynSYNSKSKNIGkkinmiQVGRLNKNK 224
Cdd:cd03798  149 RRAARVIAVSKALAE-ELVALGVPRDRV------DVIPNGVDparfqpeDRGL--GLPLDAFVIL------FVGRLIPRK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 225 NILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKNY---IKIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVY 301
Cdd:cd03798  214 GIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLgdrVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVL 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 302 PEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKnILM--IIDNYSEMSKNAIEK--SRDFDWSKIAKIYKEI 377
Cdd:cd03798  294 LEAMACGLPVVATDVGGIPEVVGDPETGLLVPPGDADALAA-ALRraLAEPYLRELGEAARArvAERFSWVKAADRIAAA 372


                 .
gi 728872487 378 Y 378
Cdd:cd03798  373 Y 373
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 78-376 4.00e-22

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 96.15  E-value: 4.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  78 FYKHNEILYYDLIDKINVINyecvhahsLFSNGYLAYKLRKNYgLEYIVAVR------NTDI--------NYFFKYMKH- 142
Cdd:cd03820   38 LDSAEKPPFYELDDNIKIKN--------LGDRKYSHFKLLLKY-FKKVRRLRkylknnKPDVvisfrtslLTFLALIGLk 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 143 LKKVGIE------IMKNAKKIIFISKSYKEY----VLNNILNEKNRELLNEKMIVIPNGIDDYWLYNSYNSKSKNIgkki 212
Cdd:cd03820  109 SKLIVWEhnnyeaYNKGLRRLLLRRLLYKRAdkivVLTEADKLKKYKQPNSNVVVIPNPLSFPSEEPSTNLKSKRI---- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 213 nmIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINknyikiiGNLSK--------EKLKDEYDG 284
Cdd:cd03820  185 --LAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDK-------LGLEDrvkllgptKNIAEEYAN 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 285 SHIFIMPSKKETFGLVYPEAMSRGLPVI-YTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIE 360
Cdd:cd03820  256 SSIFVLSSRYEGFPMVLLEAMAYGLPIIsFDCPTGPSEIIEDGENGLLVPNGDVDALAEALLRLMEDeelRKKMGKNARK 335

                        330
                 ....*....|....*.
gi 728872487 361 KSRDFDWSKIAKIYKE 376
Cdd:cd03820  336 NAERFSIEKIIKQWEE 351
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 92-376 9.98e-22

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 95.51  E-value: 9.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  92 KINVINYECVHAHSLFS-NGYLAYKLRKNYGLEYIVAVRnTDINYFFKYMKHLKK--VGIEIMK----NAKKIIFISKSY 164
Cdd:cd03821   85 RRNLREYDVVHIHGVWTyTSLAACKLARRRGIPYVVSPH-GMLDPWALQQKHWKKriALHLIERrnlnNAALVHFTSEQE 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 165 KEYVLnnilneknRELLNEKMIVIPNGID-DYWLYNSYNSKSKNIGKKINMIQ-VGRLNKNKNILTSIKVCDNLKAKGMN 242
Cdd:cd03821  164 ADELR--------RFGLEPPIAVIPNGVDiPEFDPGLRDRRKHNGLEDRRIILfLGRIHPKKGLDLLIRAARKLAEQGRD 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 243 INLKIIGEG----PIKTKLEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQG 318
Cdd:cd03821  236 WHLVIAGPDdgayPAFLQLQSSLGLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCG 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 728872487 319 FDKFFEEGyIGFSAKYNDElEIEKNILMIIDNYS------EMSKNAIEKSRDFDWSKIAKIYKE 376
Cdd:cd03821  316 LSELVEAG-CGVVVDPNVS-SLAEALAEALRDPAdrkrlgEMARRARQVEENFSWEAVAGQLGE 377
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 210-365 5.80e-21

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 88.49  E-value: 5.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  210 KKINMIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKNYIKI---IGNLSKEKLKDEYDGSH 286
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNvifLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 728872487  287 IFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDNySEMSKNAIEKSRDF 365
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLED-EELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 271-378 9.89e-19

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 81.19  E-value: 9.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 271 GNLSKEK-----LKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNIL 345
Cdd:COG0438    2 GRLVPRKgldllLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 728872487 346 MIIDNYS---EMSKNAIEKSRD-FDWSKIAKIYKEIY 378
Cdd:COG0438   82 RLLEDPElrrRLGEAARERAEErFSWEAIAERLLALY 118
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 135-374 2.31e-18

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 85.49  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 135 YFFKYMKHLKKvgiEIMKNAKKIIFISksykEYVLNNILNEKNreLLNEKMIVIPNGIDDYWLYNSYNSKSKNIGKKIN- 213
Cdd:cd03809  123 RFRLYYRLLLP---ISLRRADAIITVS----EATRDDIIKFYG--VPPEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEp 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 214 -MIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKT----KLEKKIINKNYIKIIGNLSKEKLKDEYDGSHIF 288
Cdd:cd03809  194 yFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGGKGWEDeellDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAF 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 289 IMPSKKETFGLVYPEAMSRGLPVIYTRnqgFDKFFEEGyiGFSAKY---NDELEIEKNILMIIDNYS---EMSKNAIEKS 362
Cdd:cd03809  274 VFPSLYEGFGLPVLEAMACGTPVIASN---ISVLPEVA--GDAALYfdpLDPESIADAILRLLEDPSlreELIRKGLERA 348

                        250
                 ....*....|..
gi 728872487 363 RDFDWSKIAKIY 374
Cdd:cd03809  349 KKFSWEKTAEKT 360
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 98-375 2.75e-18

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 85.47  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  98 YECVHAHSL-FSNGYLAYKLRKNYGLEYIVAVRntDI-------------NYFFKYMKHLKKVgieIMKNAKKIIFISKS 163
Cdd:cd03794   99 PDVIIAYSPpITLGLAALLLKKLRGAPFILDVR--DLwpeslialgvlkkGSLLKLLKKLERK---LYRLADAIIVLSPG 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 164 YKEYVLNnilneknRELLNEKMIVIPNGIDD---YWLYNSYNSKSKNIGKKINMIQVGRLNKNKNILTSIKVCDNLKAKg 240
Cdd:cd03794  174 LKEYLLR-------KGVPKEKIIVIPNWADLeefKPPPKDELRKKLGLDDKFVVVYAGNIGKAQGLETLLEAAERLKRR- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 241 MNINLKIIGEGPIKTKLEKKIINKNY--IKIIGNLSKEKLKDEYDGSHIFIMP-SKKETFGLVYP----EAMSRGLPVIY 313
Cdd:cd03794  246 PDIRFLFVGDGDEKERLKELAKARGLdnVTFLGRVPKEEVPELLSAADVGLVPlKDNPANRGSSPsklfEYMAAGKPILA 325

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 728872487 314 TRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIE-KSRDFDWSKIAKIYK 375
Cdd:cd03794  326 SDDGGSDLAVEINGCGLVVEPGDPEALADAILELLDDpelRRAMGENGRElAEEKFSREKLADRLL 391
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 2-375 3.32e-18

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 84.95  E-value: 3.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   2 KIMHIC-SYYPSSKLYENLLDKLNNENvdNTVYIPCKPSSVEKIKRSSKNSKFIISPIflegknllekfkncSERALFYK 80
Cdd:cd03808    1 KILFIVnVDGGFQSFRLPLIKALVKKG--YEVHVIAPDGDKLSDELKELGVKVIDIPI--------------LRRGINPL 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  81 HNEILYYDLIDKINVINYECVHAHSLFSN--GYLAYKLRKNYGLEYIVA------VRNTDINYFFKYMKHLkkvgieIMK 152
Cdd:cd03808   65 KDLKALFKLYKLLKKEKPDIVHCHTPKPGilGRLAARLAGVPKVIYTVHglgfvfTEGKLLRLLYLLLEKL------ALL 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 153 NAKKIIFISKSYKEYVLNNILNEKNrellnEKMIVIPNGID-DYWLYNSYNSKSKNIgkKINMiqVGRLNKNKNILTSIK 231
Cdd:cd03808  139 FTDKVIFVNEDDRDLAIKKGIIKKK-----KTVLIPGSGVDlDRFQYSPESLPSEKV--VFLF--VARLLKDKGIDELIE 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 232 VCDNLKAKGMNINLKIIGEGPiktKLEKKIINKNYIKIIGNL----SKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSR 307
Cdd:cd03808  210 AAKILKKKGPNVRFLLVGDGE---LENPSEILIEKLGLEGRIeflgFRSDVPELLAESDVFVLPSYREGLPRSLLEAMAA 286

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728872487 308 GLPVIYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDNYS---EMSKNAIEK-SRDFDWSKIAKIYK 375
Cdd:cd03808  287 GRPVITTDVPGCRELVIDGVNGFLVPPGDVEALADAIEKLIEDPElrkEMGEAARKRvEEKFDEEKVVNKLL 358
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 50-363 4.78e-18

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 84.33  E-value: 4.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  50 NSKFIISPIFLEGKNLLEKFKNCSERALFYKHNEILYYDLIDK---------INVINYECVHAHSLFSNGYLAYKlrKNY 120
Cdd:cd03811   27 KRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLkailklkriLKRAKPDVVISFLGFATYIVAKL--AAA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 121 GLEYIVAVRNT-DINYFFKYMKHLKKVGIeimKNAKKIIFISKSYKEyvlnniLNEKNRELLNEKMIVIPNGIDDywlyN 199
Cdd:cd03811  105 RSKVIAWIHSSlSKLYYLKKKLLLKLKLY---KKADKIVCVSKGIKE------DLIRLGPSPPEKIEVIYNPIDI----D 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 200 SYNSKSK-----NIGKKINMIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEkkiinknyikiigNLS 274
Cdd:cd03811  172 RIRALAKepilnEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELE-------------KLA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 275 KE-KLKD-------------EYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYNDEL-- 338
Cdd:cd03811  239 KElGLAErviflgfqsnpypYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAal 318

                        330       340
                 ....*....|....*....|....*.
gi 728872487 339 -EIEKNILMIIDNYSEMSKNAIEKSR 363
Cdd:cd03811  319 aGILAALLQKKLDAALRERLAKAQEA 344
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 77-378 5.01e-16

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 78.52  E-value: 5.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  77 LFYKHNEILYYDLIDKINVINYECVHAHSLFSNGYLAYKLRKNYGLEYIVAVRNtdinYFFKYMKHlkkvgiEIMKNAKK 156
Cdd:cd03823   76 LFETYNPGLRRLLARLLEDFRPDVVHTHNLSGLGASLLDAARDLGIPVVHTLHD----YWLLCPRQ------FLFKKGGD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 157 IiFISKSykEYVLNNILneknRELLNEKMI-VIPNGI--DDYWLYNSYNSkskniGKKINMIQVGRLNKNKNILTSIKVC 233
Cdd:cd03823  146 A-VLAPS--RFTANLHE----ANGLFSARIsVIPNAVepDLAPPPRRRPG-----TERLRFGYIGRLTEEKGIDLLVEAF 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 234 DNLKAKgmNINLKIIGEGPIKTklEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMPSK-KETFGLVYPEAMSRGLPVI 312
Cdd:cd03823  214 KRLPRE--DIELVIAGHGPLSD--ERQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVI 289

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 728872487 313 YTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIID--NYSEMSKNAIEKSRDFDWSKIAkiYKEIY 378
Cdd:cd03823  290 ASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRRLLTdpALLERLRAGAEPPRSTESQAEE--YLKLY 355
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
217-350 8.66e-15

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 70.62  E-value: 8.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  217 VGRLNKN-KNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKNYIKIIGNLskEKLKDEYDGSHIFIMPSKKE 295
Cdd:pfam13692   7 VGRLHPNvKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAGLEDRVIFTGFV--EDLAELLAAADVFVLPSLYE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 728872487  296 TFGLVYPEAMSRGLPVIYTRNQGFdKFFEEGYIGFSAKYNDELEIEKNILMIIDN 350
Cdd:pfam13692  85 GFGLKLLEAMAAGLPVVATDVGGI-PELVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 89-378 1.14e-14

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 74.70  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  89 LIDKINVINYECVHAHSLFSNGYLAYKLRK--NYGLEYIVAVRNTDINY--FFKYMKHLKKVGIEimknakkiifisKSY 164
Cdd:cd04962   76 IVEVAKEHKLDVLHAHYAIPHASCAYLAREilGEKIPIVTTLHGTDITLvgYDPSLQPAVRFSIN------------KSD 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 165 KEYVLNNILNEKNRELL--NEKMIVIPNGID-DYW--LYNSYNSKSKNI--GKKInMIQVGRLNKNKNILTSIKVCDNLk 237
Cdd:cd04962  144 RVTAVSSSLRQETYELFdvDKDIEVIHNFIDeDVFkrKPAGALKRRLLAppDEKV-VIHVSNFRPVKRIDDVVRVFARV- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 238 AKGMNINLKIIGEGPIKTKLEKKIINKNYIKIIGNLSK-EKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRN 316
Cdd:cd04962  222 RRKIPAKLLLVGDGPERVPAEELARELGVEDRVLFLGKqDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNA 301

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 728872487 317 QGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEKSR-DFDWSKIAKIYKEIY 378
Cdd:cd04962  302 GGIPEVVKHGETGFLSDVGDVDAMAKSALSILEDdelYNRMGRAARKRAAeRFDPERIVPQYEAYY 367
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 85-361 1.55e-14

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 74.02  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  85 LYYDLIDKINVINYECVHAHsLFSNGYLAYKLRKNYGLE--YIVAVRNTDINYFFKymKHLKKVGIEIMKNAKKIIFISK 162
Cdd:cd03799   58 LLYAIVGLNKKGAYDIIHCQ-FGPLGALGALLRRLKVLKgkLVTSFRGYDISMYVI--LEGNKVYPQLFAQGDLFLPNCE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 163 SYKEYVLNNILNEKnrellneKMIVIPNGIDDywlyNSYNSKSKNI--GKKINMIQVGRLNKNKNILTSIKVCDNLKAKG 240
Cdd:cd03799  135 LFKHRLIALGCDEK-------KIIVHRSGIDC----NKFRFKPRYLplDGKIRILTVGRLTEKKGLEYAIEAVAKLAQKY 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 241 MNINLKIIGEGPIKTKLEKKIINKNYIKII---GNLSKEKLKDEYDGSHIFIMPS------KKETFGLVYPEAMSRGLPV 311
Cdd:cd03799  204 PNIEYQIIGDGDLKEQLQQLIQELNIGDCVkllGWKPQEEIIEILDEADIFIAPSvtaadgDQDGPPNTLKEAMAMGLPV 283

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 728872487 312 IYTRNQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEK 361
Cdd:cd03799  284 ISTEHGGIPELVEDGVSGFLVPERDAEAIAEKLTYLIEHpaiWPEMGKAGRAR 336
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 178-330 7.28e-14

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 70.51  E-value: 7.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 178 RELLNEKMIVIPNGIDDYWL---YNSYNSKSKNIGKKINMIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIK 254
Cdd:cd01635   74 ARLLGIPIVVTVHGPDSLEStrsELLALARLLVSLPLADKVSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGER 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 255 TKLEKKIINKNYI---KIIGNLSKEKLKDEY-DGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGF 330
Cdd:cd01635  154 EEEEALAAALGLLervVIIGGLVDDEVLELLlAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGL 233
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 89-378 3.42e-13

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 70.04  E-value: 3.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  89 LIDKINVINYECVH---AHSLFSnGYLAYKLRKnyGLEYIVAVRNTDINYFFKymKHLKKVGIEIMKNAKKIIFISKSYK 165
Cdd:cd03807   71 LAKLIRKRNPDVVHtwmYHADLI-GGLAAKLAG--GVKVIWSVRSSNIPQRLT--RLVRKLCLLLSKFSPATVANSSAVA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 166 EYVLNNILNeknrellNEKMIVIPNGIDDYWLYNSYNSKSKNI------GKKINMIQVGRLNKNKNILTSIKVCDNLKAK 239
Cdd:cd03807  146 EFHQEQGYA-------KNKIVVIYNGIDLFKLSPDDASRARARrrlglaEDRRVIGIVGRLHPVKDHSDLLRAAALLVET 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 240 GMNINLKIIGEGPIKTKLEKkiinknyikiignLSKEKLKDE--------------YDGSHIFIMPSKKETFGLVYPEAM 305
Cdd:cd03807  219 HPDLRLLLVGRGPERPNLER-------------LLLELGLEDrvhllgersdvpalLPAMDIFVLSSRTEGFPNALLEAM 285

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 728872487 306 SRGLPVIYTRNQGFDKFFEEG-YIGFSAKynDELEIEKNILMII---DNYSEMSKNAIEKSRD-FDWSKIAKIYKEIY 378
Cdd:cd03807  286 ACGLPVVATDVGGAAELVDDGtGFLVPAG--DPQALADAIRALLedpEKRARLGRAARERIANeFSIDAMVRRYETLY 361
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 80-312 2.19e-12

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 67.70  E-value: 2.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  80 KHNEILYY-DLIDKINVINYECVHAHSLFSNGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHLKKVGIEIMKNAKKII 158
Cdd:cd03812   62 KKNIIKYFiKLLKLIKKEKYDIVHVHGSSSNGIILLLAAKAGVPVRIAHSHNTKDSSIKLRKIRKNVLKKLIERLSTKYL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 159 FISKSYKEYVLNnilneknrELLNEKMIVIPNGID-DYWLYNSYNS----KSKNIGKKINMIQVGRLNKNKNILTSIKVC 233
Cdd:cd03812  142 ACSEDAGEWLFG--------EVENGKFKVIPNGIDiEKYKFNKEKRrkrrKLLILEDKLVLGHVGRFNEQKNHSFLIDIF 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 234 DNLKAKGMNINLKIIGEGPIKTKLEKKIINKNYIKIIGNL-SKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVI 312
Cdd:cd03812  214 EELKKKNPNVKLVLVGEGELKEKIKEKVKELGLEDKVIFLgFRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCL 293
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 151-358 2.73e-12

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 67.30  E-value: 2.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 151 MKNAKKIIFISKSYKEyvlnnilNEKNRELLNEKMIVIPNGIDDywlyNSYNS--------KSKNIGKKInMIQVGRLNK 222
Cdd:cd03795  135 LRRADRIIATSPNYVE-------TSPTLREFKNKVRVIPLGIDK----NVYNIprvdfeniKREKKGKKI-FLFIGRLVY 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 223 NKNILTSIKVcdnlkAKGMNINLKIIGEGPIKTKLEKKIINKNYIKII--GNLSKEKLKDEYDGSHIFIMPS--KKETFG 298
Cdd:cd03795  203 YKGLDYLIEA-----AQYLNYPIVIGGEGPLKPDLEAQIELNLLDNVKflGRVDDEEKVIYLHLCDVFVFPSvlRSEAFG 277

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 728872487 299 LVYPEAMSRGLPVIYTR-NQGFDKFFEEGYIGFSAKYNDELEIEKNILMIIDN---YSEMSKNA 358
Cdd:cd03795  278 IVLLEAMMCGKPVISTNiGTGVPYVNNNGETGLVVPPKDPDALAEAIDKLLSDeelRESYGENA 341
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 214-367 3.37e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 67.43  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 214 MIQVGRLNKNKNILTSIKVCDNLKakgmNINLKIIGEGPIKTKLEKKIINKNYIKIiGNLSKEKLKDEYDGSHIFIMPSK 293
Cdd:PLN02871 266 IVYVGRLGAEKNLDFLKRVMERLP----GARLAFVGDGPYREELEKMFAGTPTVFT-GMLQGDELSQAYASGDVFVMPSE 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 294 KETFGLVYPEAMSRGLPVIYTRNQGFDKFF---EEGYIGF---SAKYNDELEIEKNILMIIDNYSEMSKNAIEKSRDFDW 367
Cdd:PLN02871 341 SETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTGFlytPGDVDDCVEKLETLLADPELRERMGAAAREEVEKWDW 420
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 76-312 6.15e-12

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 66.22  E-value: 6.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487  76 ALFYKHNEILYYdLIDKINVinyECVHAHSLFSN--GYLAYKLrknYGLEYIVAVRNTDINYFfkymkHLKKVGIEIMKN 153
Cdd:cd03819   59 LRALLGNVRLAR-LIRRERI---DLIHAHSRAPAwlGWLASRL---TGVPLVTTVHGSYLATY-----HPKDFALAVRAR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 154 AKKIIFISKSYKEYVLNNIlneknrELLNEKMIVIPNGIDD-------YWLYNSYNSKSKNIgKKINMiqVGRLNKNKNI 226
Cdd:cd03819  127 GDRVIAVSELVRDHLIEAL------GVDPERIRVIPNGVDTdrfppeaEAEERAQLGLPEGK-PVVGY--VGRLSPEKGW 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 227 LTSIKVCDNLKaKGMNINLKIIGEGPIKTKLEKKIINKNYI---KIIGNlsKEKLKDEYDGSHIFIMPSKKETFGLVYPE 303
Cdd:cd03819  198 LLLVDAAAELK-DEPDFRLLVAGDGPERDEIRRLVERLGLRdrvTFTGF--REDVPAALAASDVVVLPSLHEEFGRVALE 274


                 ....*....
gi 728872487 304 AMSRGLPVI 312
Cdd:cd03819  275 AMACGTPVV 283
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 217-378 6.25e-10

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 60.00  E-value: 6.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 217 VGRLNKNKNILTSIKVCDNLKAKgMNINLKIIGEGPIKTKLEKKIINKNYIkiiGNLSKEKLKDEYDGSHIFIMPSKKET 296
Cdd:cd03814  204 VGRLAPEKNLEALLDADLPLAAS-PPVRLVVVGDGPARAELEARGPDVIFT---GFLTGEELARAYASADVFVFPSRTET 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 297 FGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYND-ELEIEKNILMIID--NYSEMSKNAIEKSRDFDWSKIAKI 373
Cdd:cd03814  280 FGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDaAAFAAALRALLEDpeLRRRMAARARAEAERYSWEAFLDN 359


                 ....*
gi 728872487 374 YKEIY 378
Cdd:cd03814  360 LLDYY 364
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 184-378 1.06e-09

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 59.27  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 184 KMIVIPNGID-DYW--LYNSYNSKSKNIGKKINMIQVGRL---NKNKNILTSIKVCDNLkAKGMNINLKIIGEGPiktkl 257
Cdd:cd03825  162 PVVVIPNGIDtEIFapVDKAKARKRLGIPQDKKVILFGAEsvtKPRKGFDELIEALKLL-ATKDDLLLVVFGKND----- 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 258 EKKIINKNYIKIIGNLS-KEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYND 336
Cdd:cd03825  236 PQIVILPFDIISLGYIDdDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGD 315

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 728872487 337 ELEIEKNILMIIDNYSEM---SKNAIEK-SRDFDWSKIAKIYKEIY 378
Cdd:cd03825  316 VQALAEAIEWLLANPKEReslGERARALaENHFDQRVQAQRYLELY 361
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 217-336 1.82e-09

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 58.62  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 217 VGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMPS---- 292
Cdd:cd05844  195 VGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAALGRVRFLGALPHAEVQDWMRRAEIFCLPSvtaa 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 728872487 293 --KKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFSAKYND 336
Cdd:cd05844  275 sgDSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGD 320
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 184-371 2.26e-09

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 58.41  E-value: 2.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 184 KMIVIPNGIDDYwLYNSYNSKSKNIG-------KKInMIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGeGPI--- 253
Cdd:cd03800  188 RINVVPPGVDLE-RFFPVDRAEARRArlllppdKPV-VLALGRLDPRKGIDTLVRAFAQLPELRELANLVLVG-GPSddp 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 254 -------KTKLEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEG 326
Cdd:cd03800  265 lsmdreeLAELAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDG 344

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 728872487 327 YIGFSAKYNDELEIEKNILMIIDN---YSEMSKNAIEKSRD-FDWSKIA 371
Cdd:cd03800  345 RTGLLVDPHDPEALAAALRRLLDDpalWQRLSRAGLERARAhYTWESVA 393
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 184-314 9.33e-09

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 56.30  E-value: 9.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 184 KMIVIPNGIDDYwLYNSYNSKSKNIGKKINMIQ-------VGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTK 256
Cdd:cd04951  155 KSVPVYNGIDLN-KFKKDINVRLKIRNKLNLKNdefvilnVGRLTEAKDYPNLLLAISELILSKNDFKLLIAGDGPLRNE 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 728872487 257 LEKKIINKNYIKIIGNL-SKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYT 314
Cdd:cd04951  234 LERLICNLNLVDRVILLgQISNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVAT 292
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 159-366 4.74e-07

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 51.13  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 159 FISKSYkeyvlnnilNEKNRELLNEKMIVIPNGID--DYWLYNSynsksknigKKINMIQVGRLNKNKNILTSIKVcdnl 236
Cdd:cd03802  133 YVSISD---------AQRAATPPIDYLTVVHNGLDpaDYRFQPD---------PEDYLAFLGRIAPEKGLEDAIRV---- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 237 kAKGMNINLKIIG--EGPIKTKLEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMPSK-KETFGLVYPEAMSRGLPVIY 313
Cdd:cd03802  191 -ARRAGLPLKIAGkvRDEDYFYYLQEPLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIA 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 728872487 314 TRNQGFDKFFEEGYIGFsakyndeleieknilmIIDNYSEMSKnAIEKSRDFD 366
Cdd:cd03802  270 YRRGGLPEVIQHGETGF----------------LVDSVEEMAE-AIANIDRID 305
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 282-380 5.65e-07

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 51.41  E-value: 5.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 282 YDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTRNQG-------FDKFFEEGYiGFSAKYNDELEIEKNILMII------ 348
Cdd:cd03791  366 YAGADFFLMPSRFEPCGLVQMYAMRYGTLPIVRRTGGladtvfdYDPETGEGT-GFVFEDYDAEALLAALRRALalyrnp 444

                         90       100       110
                 ....*....|....*....|....*....|..
gi 728872487 349 DNYSEMSKNAieKSRDFDWSKIAKIYKEIYIN 380
Cdd:cd03791  445 ELWRKLQKNA--MKQDFSWDKSAKEYLELYRS 474
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
89-193 1.01e-06

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 48.30  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487   89 LIDKINVINYECVHAHSLFSNGYLAYKLRKNYGLEYIVAVRNTDINYFFKYMKHLKKVGIE------IMKNAKKIIFISK 162
Cdd:pfam13439  63 LRRLLRRERPDVVHAHSPFPLGLAALAARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLrrlerrLLRRADRVIAVSE 142

                          90       100       110
                  ....*....|....*....|....*....|.
gi 728872487  163 SYKEYVlnnilnEKNRELLNEKMIVIPNGID 193
Cdd:pfam13439 143 AVADEL------RRLYGVPPEKIRVIPNGVD 167
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
152-369 1.14e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 50.17  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 152 KNAKKII---FISKSYKEYvlnnilneknreLLNEKMIVIPNGIDdywLYNSYNSKSKNIGKKIN-------MIQVGRLN 221
Cdd:PRK15484 139 KNAKIIVpsqFLKKFYEER------------LPNADISIVPNGFC---LETYQSNPQPNLRQQLNispdetvLLYAGRIS 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 222 KNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTK----------LEKKIINKNYIKIIGNLSKEKLKDEYDGSHIFIMP 291
Cdd:PRK15484 204 PDKGILLLMQAFEKLATAHSNLKLVVVGDPTASSKgekaayqkkvLEAAKRIGDRCIMLGGQPPEKMHNYYPLADLVVVP 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 292 SK-KETFGLVYPEAMSRGLPVIYTRNQGFDKFFEEGYIGFS-AKYNDELEIEKNILMIIDNySEMSKNAiEKSRDFDWSK 369
Cdd:PRK15484 284 SQvEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHlAEPMTSDSIISDINRTLAD-PELTQIA-EQAKDFVFSK 361
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 129-365 1.82e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 49.22  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 129 RNTDINYFFKYMKHLKKVGIEI----MKNAKKIIFI-SKSYKEYVLNN--------ILNEKNRELLNE------KMIVIP 189
Cdd:cd04949   63 RPTLTGQVILNTKGPAKKGAVLhnehVKNNDDPEHSlIKNFYKYVFENlnkydaiiVSTEQQKQDLSErfnkypPIFTIP 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 190 NGIDDYWLYNSYNSKSKNigKKInmIQVGRLNKNKNILTSIKVCDNLKAKGMNINLKIIGEGPIKTKLEKKIINKnyiki 269
Cdd:cd04949  143 VGYVDQLDTAESNHERKS--NKI--ITISRLAPEKQLDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEEL----- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 270 igNLSK--------EKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVI-YTRNQGFDKFFEEGYIGFSAKYNDELEI 340
Cdd:cd04949  214 --HLEDnvflkgyhSNLDQEYQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVsYDVKYGPSELIEDGENGYLIEKNNIDAL 291

                        250       260
                 ....*....|....*....|....*...
gi 728872487 341 EKNILMIIDNYS---EMSKNAIEKSRDF 365
Cdd:cd04949  292 ADKIIELLNDPEklqQFSEESYKIAEKY 319
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 183-315 1.22e-04

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 43.77  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 183 EKMIVIPNGIDDYWLYNSYNSKSKNigkKINMIQVGRLNKNKNI--LTSI--KVCDNLKakgmNINLKIIGEGPIKTKLE 258
Cdd:cd03796  168 RIVSVIPNAVDSSDFTPDPSKPDPN---KITIVVISRLVYRKGIdlLVGIipRICKKHP----NVRFIIGGDGPKRIELE 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 259 KKIINKNYI---KIIGNLSKEKLKDEYDGSHIFIMPSKKETFGLVYPEAMSRGLPVIYTR 315
Cdd:cd03796  241 EMREKYQLQdrvELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCIAIVEAASCGLLVVSTR 300
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 282-317 3.27e-03

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 39.30  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 728872487  282 YDGSHIFIMPSKKETFGLVYPEAMSRGLPVIyTRNQ 317
Cdd:TIGR04047 274 YRCADAFAFPSLKEGFGLVVLEALASGIPVV-ASDI 308
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
288-378 5.18e-03

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 38.54  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728872487 288 FIMPSKKETFGLVYPEAMSRGLPVIYTRNQ-GFDKFFEEGYIGFSAKYNDELEIEKNILMIIDNYSEMSKNAIEKSrdfd 366
Cdd:PRK09922 261 LLLTSKFEGFPMTLLEAMSYGIPCISSDCMsGPRDIIKPGLNGELYTPGNIDEFVGKLNKVISGEVKYQHDAIPNS---- 336

                         90
                 ....*....|..
gi 728872487 367 wskIAKIYKEIY 378
Cdd:PRK09922 337 ---IERFYEVLY 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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