|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-824 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1616.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 1 MKE-YRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYD 79
Cdd:COG0495 1 MQErYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 80 AFGLPAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCP 159
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 160 KCKTVLANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSD 239
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 240 TKIRVFTTRPDTLWGVTFMALAPESPLVEELVPEEKKEELQEFLERVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERI 319
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 320 PIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRDlDPEKMEEAYEGEGIMVNSGPFDGTPSSEGIE 399
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD-DPDILEEAYTGDGVLINSGEFDGLDSEEAKE 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 400 KVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGIVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKRT 479
Cdd:COG0495 400 AIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTGGSPLARAPEWVNV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 480 KCPICGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYL 559
Cdd:COG0495 480 TCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLV 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 560 NFDEPFTNLFTQGMIY---KDG------AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRF 630
Cdd:COG0495 560 SFDEPFKRLLTQGMVLevgKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRF 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 631 IKRLWNTFYTVLPFVKEENTENlvlkNSTEKELRRKLHSIIKKITEDIEgGFKFNTAISGLMELVNHLSQYLNSVPQeew 710
Cdd:COG0495 640 LNRVWRLVVDEAEALKLDVADL----SEADKELRRALHKTIKKVTEDIE-RLRFNTAIAALMELVNALYKAKDSGEA--- 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 711 NRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQAWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEAL 790
Cdd:COG0495 712 DRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEEL 791
|
810 820 830
....*....|....*....|....*....|....
gi 728866913 791 KRIVLERERVKEYVDGKPIKKFLYVRGRIVNIVV 824
Cdd:COG0495 792 EAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVV 825
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
4-824 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1186.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 4 YRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGL 83
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 84 PAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKT 163
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 164 VLANEQV-KDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWIGKSTGAEIDFPVEGSDTKI 242
Cdd:TIGR00396 161 VLANEQVdSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEKI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 243 RVFTTRPDTLWGVTFMALAPESPLVEELVPEEKKeeLQEFLERVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERIPIY 322
Cdd:TIGR00396 241 TVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPK--VAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 323 VANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRDLdpeKMEEAYEGEGIMVNSGPFDGTPSSEGIEKVI 402
Cdd:TIGR00396 319 VANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDL---SLTAAYTEDGVLVNSGEFNGLNSSEARNAII 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 403 NWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGIVPVPEEDLPVRLPKDVEFLPTGQSPLSFHEGFKRTKCP 482
Cdd:TIGR00396 396 DMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCP 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 483 ICGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLNFD 562
Cdd:TIGR00396 476 SCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTK 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 563 EPFTNLFTQGMI--------------------------------YKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFM 610
Cdd:TIGR00396 556 EPFKKLINQGMVlgfyyppngkvpadvlterdekgkdkaggelvYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFM 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 611 APPEKDAEWSDAGIEGVHRFIKRLWNTFYTVLPfVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISG 690
Cdd:TIGR00396 636 GPIAASLEWNESGLEGARRFLDRVWNLVYEITG-ELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRESFNTAISA 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 691 LMELVNHLSQYLNSvpqeewnrKLLREIVEKLTLALSPFAPHLAEEFWHDLG-NDSLVVQQAWPSYDPKALEVEEVEIAI 769
Cdd:TIGR00396 715 MMELLNKLYKAKKE--------ALMLEYLKGFVTVLSPFAPHLAEELWEKLGsEPFIIDNAKWPVVDETALVEDKTLIVV 786
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 728866913 770 QINGKVRDKVVVPVDISEEALKRIVLERERVKEYVDGKPIKKFLYVRGRIVNIVV 824
Cdd:TIGR00396 787 QVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVI 841
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
8-824 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 997.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 8 EIEKKWQEVWEEKKVFYTPQR--SEKPKYYALVMFPYPSGT-LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP 84
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDDvdTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 85 AENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTV 164
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 165 LANEQVKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTgWPEHVKTMQRNWIGKSTGAEIDFPVEG-----SD 239
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVLDgegkeRD 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 240 TKIRVFTTRPDTLWGVTFMALAPESPLVEELVPEEKKEELQEFLERVKQQDRFRRTSVEAEKEGFFLGRYAINPVTGERI 319
Cdd:PLN02563 323 EKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINPATGEAI 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 320 PIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRDLDPEkmEEAYEGEGIMVNSG----PFDGTPSS 395
Cdd:PLN02563 403 PIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDA--EKAYTGEGVIVNSSssglDINGLSSK 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 396 EGIEKVINWLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIIYCEKCG-IVPVPEEDLPVRLPKDVEFLP--TGQSPLSF 472
Cdd:PLN02563 481 EAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTPtgTGEPPLAK 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 473 HEGFKRTKCPICGGEAQRETDTMDTFVDSSWYFLRYVNPHLEDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKV 552
Cdd:PLN02563 561 AVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKV 640
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 553 LHDLGYLNFDEPFTNLFTQGMI--------YKD----------------------------------------------- 577
Cdd:PLN02563 641 LYDIGVVSTKEPFQCLVNQGMIlgeveytaFKDsdgeyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliar 720
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 578 GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTENLVLKN 657
Cdd:PLN02563 721 AHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVGAPLPDGSFRDGTVVTDE 800
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 658 STEKELRRKLHSIIKKITEDIEgGFKFNTAISGLMELVNHLSQylnsvpqeeWNrKLLREIVEKLTLALSPFAPHLAEEF 737
Cdd:PLN02563 801 EPSLEQLRLLHKCIAKVTEEIE-STRFNTAISAMMEFTNAAYK---------WD-KVPREAIEPFVLLLSPYAPHLAEEL 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 738 WHDLGNDSLVVQQAWPSYDPKALEVEEVEIAIQINGKVRDKVVVPVDISEEALKRIVLERERVKEYVDGKPIKKFLYVRG 817
Cdd:PLN02563 870 WFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPG 949
|
....*..
gi 728866913 818 RIVNIVV 824
Cdd:PLN02563 950 KILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
33-619 |
1.03e-139 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 415.88 E-value: 1.03e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 33 KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQVK 112
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 113 KLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCpkcktvlaneqvkdgkcercgtsvtiRHLEQWFF 192
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 193 KI--TDYAERLLNDLDKLTGWPehvktmqrnwigkstgaeidfpvegsdtkirvfttrpdtlwgvtfmalapesplveel 270
Cdd:cd00812 135 KYseTEWKEKLLKDLEKLDGWP---------------------------------------------------------- 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 271 vpeekkeelqeflERVKQQDRfrrtsveaekegfflgryainpvtgeripiyvanyilmeygtgaimgvpahdqrdfsfa 350
Cdd:cd00812 157 -------------EEVRAMQE----------------------------------------------------------- 164
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 351 kkygipikvvikpadrdldpekmeeayegegimvnsgpfdgtpssegiekviNWLEekgigkrsvqyklrdwlISRQRYW 430
Cdd:cd00812 165 ----------------------------------------------------NWIG-----------------CSRQRYW 175
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 431 GAPIPIiycekcgivpvpeedlpvrlpkdveflptgqsplsfhegfkrtkcpicggeaqreTDTMDTFVDSSWYFLRYVN 510
Cdd:cd00812 176 GTPIPW-------------------------------------------------------TDTMESLSDSTWYYARYTD 200
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 511 PHLEDKP------FEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVLHDLGYLnFDEPFTNLFTQGMIYKDGAKMSKS 584
Cdd:cd00812 201 AHNLEQPyegdleFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEGEKMSKS 279
|
570 580 590
....*....|....*....|....*....|....*
gi 728866913 585 KGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEW 619
Cdd:cd00812 280 KGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
2-776 |
9.70e-118 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 377.09 E-value: 9.70e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81
Cdd:TIGR00422 3 KDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 82 GLPAEnAAIEKGIHPE-----------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYK 144
Cdd:TIGR00422 83 GIATQ-VKVEKKLGAEgktkhdlgreefrekiwEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 145 NGLAYKKKAAVNWCPKCKTVLANEQVkdgkcercgtsvtirhleqwffkitDYAERLLndldKLTGwpehvktmqrnwig 224
Cdd:TIGR00422 162 KGLIYRGEYLVNWDPKLNTAISDIEV-------------------------EYKEVKG----KLYY-------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 225 kstgaeIDFPVE-GSDTKIRVFTTRPDTLWGVTFMALAPESplveelvpeekkeelqeflERVKQqdrfrrtsveaekeg 303
Cdd:TIGR00422 199 ------IRYPLAnGSKDYLVVATTRPETMFGDTAVAVHPED-------------------ERYKH--------------- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 304 fFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVI-------------KPADRDLDP 370
Cdd:TIGR00422 239 -LIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILdedgllnenagkyQGLTRFEAR 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 371 EKMEEAYEGEGIMVNSGPFD---------GTP------------SSEGIEKVINWLEEKGI----GKRSVQY-----KLR 420
Cdd:TIGR00422 318 KKIVEDLKEEGLLVKIEPHThnvgtcwrsGTVvepllskqwfvkVEKLADKALEAAEEGEIkfvpKRMEKRYlnwlrNIK 397
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 421 DWLISRQRYWGAPIPIIYCEKCGIVPVPEEDLPVRLPKDveflpTGQSPlsfhegfkrtkcpicggEAQRETDTMDTFVD 500
Cdd:TIGR00422 398 DWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDKTN-----TGPSV-----------------ELEQDTDVLDTWFS 455
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 501 SSWYFLRYVNPHLEDKPFEpddvNYWlPVDQYIGGveHAVLHLLYSRFVTKVLHDLGYLnfdePFTNLFTQGMIY-KDGA 579
Cdd:TIGR00422 456 SSLWPFSTLGWPDETKDLK----KFY-PTDLLVTG--YDIIFFWVARMIFRSLALTGQV----PFKEVYIHGLVRdEQGR 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 580 KMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVLpfvkeENTENLVLKNST 659
Cdd:TIGR00422 525 KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASRFVL-----MNLSDDLELSGG 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 660 EKELR-------RKLHSIIKKITEDIEgGFKFNTAISGLMELVNHL--SQYLNSVPQEEWN---------RKLLREIVEK 721
Cdd:TIGR00422 600 EEKLSladrwilSKLNRTIKEVRKALD-KYRFAEAAKALYEFIWNDfcDWYIELVKYRLYNgneaekkaaRDTLYYVLDK 678
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 728866913 722 LTLALSPFAPHLAEEFWHDLGNDSL-VVQQAWPSYDPKALEVE---EVEIAIQINGKVR 776
Cdd:TIGR00422 679 ALRLLHPFMPFITEEIWQHFKEGADsIMLQSYPVVDAEFVDEEaekAFELLKEIIVSIR 737
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
220-406 |
3.35e-114 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 344.53 E-value: 3.35e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 220 RNWIGKSTGAEIDFPVEGSDTKIRVFTTRPDTLWGVTFMALAPESPLVEELvpEEKKEELQEFLERVKQQDRFRRTSVEA 299
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKL--AEKNPEVAAFIEECKNTSEIERTSETK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 300 EKEGFFLGRYAINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRDLDPEKMEEAYEG 379
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLDLDIMTEAYTE 158
|
170 180
....*....|....*....|....*..
gi 728866913 380 EGIMVNSGPFDGTPSSEGIEKVINWLE 406
Cdd:pfam13603 159 EGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
2-791 |
5.97e-108 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 349.49 E-value: 5.97e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYyalVMF---PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGY 78
Cdd:PRK13208 8 KKYDPEELEEKWQKIWEEEGTYKFDPDERKPVY---SIDtppPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 79 DAFGLP----AENaaiEKGIHP------------EEWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQL 142
Cdd:PRK13208 85 DDNGLPterkVEK---YYGIRKddisreefielcRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 143 YKNGLAYKKKAAVNWCPKCKTVLANEQVKDGkcERCGTsvtirhleqwffkitdyaerlLNDldkltgwpehvktmqrnw 222
Cdd:PRK13208 162 YKKGLIYRAEAPVLWCPRCETAIAQAEVEYR--EREGK---------------------LNY------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 223 igkstgaeIDFPVEGSDtKIRVFTTRPdtlwgvtfmalapesplveELV---------PEEkkeelqeflERVKQqdrfr 293
Cdd:PRK13208 201 --------IKFPVEDGE-EIEIATTRP-------------------ELLpacvavvvhPDD---------ERYKH----- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 294 rtsveaekegfFLGRYAINPVTGERIPIYVANYILMEYGTGAIM----GvpahDQRDFSFAKKYGIPIKVVIkpaDRDld 369
Cdd:PRK13208 239 -----------LVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMictfG----DKTDVTWWRELNLPTRIII---DED-- 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 370 pEKMEEAYegegimvnsGPFDGTPSSEGIEKVINWLEEKG-IGK-----RSVQ--------------------------- 416
Cdd:PRK13208 299 -GRMTEAA---------GKLAGLTIEEARKKIVEDLKSGGlLGKqepikHNVKfcercdtpleilvtrqwfikvldlkee 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 417 --------------YKLR----------DWLISRQRYWGAPIPIIYCEKCG-IVPVPEEDLPVRlpkdveflPTGQSPLS 471
Cdd:PRK13208 369 llergkeinwypehMRVRlenwieglnwDWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPVD--------PTKDEPPG 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 472 FhegfkrtKCPICG-GEAQRETDTMDTFVDSS--------WyflrYVNPHLEDKPFePDDVN--------YWlpvdqyig 534
Cdd:PRK13208 441 Y-------KCPQCGsPGFEGETDVMDTWATSSitplivtgW----ERDEDLFEKVF-PMDLRpqghdiirTW-------- 500
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 535 gvehavlhlLYSRFVtKVLhdlgYLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILfMAPP 613
Cdd:PRK13208 501 ---------LFYTIL-RAY----LLTGKLPWKNIMISGMVLdPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAA-SARL 565
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 614 EKDAEWSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTENLVLKNSTEKELRRKLHSIIKKITEDIEgGFKFNTAISGLME 693
Cdd:PRK13208 566 GSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPEPDKAEVLEPLDRWILAKLAKVVEKATEALE-NYDFAKALEEIES 644
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 694 LVNHL--SQYLNSVPQEEWNRKL----------LREIVEKLTLALSPFAPHLAEEFWHDLGNDSlVVQQAWPSYDPKALE 761
Cdd:PRK13208 645 FFWHVfcDDYLELVKSRAYGEDEeeeqksarytLYTVLDTLLRLLAPFLPFITEEVWSWLYGGS-VHRASWPEPDEELID 723
|
890 900 910 920
....*....|....*....|....*....|....*....|....*..
gi 728866913 762 ---VEEVEIAIQINGKVR--------------DKVVVPVDISEEALK 791
Cdd:PRK13208 724 eedEELGELAKEILSAVRkykseaglslnaplKKVEVYGPADLELLE 770
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
47-815 |
7.41e-81 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 278.68 E-value: 7.41e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 47 LHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP----AEnaAIEKG----------IH--PEEWTRK-----NI- 104
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARGdpetielyksLYgiPEEELEKfkdpeYIv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 105 ----NTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKcercgt 180
Cdd:PRK12300 79 eyfsEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGE------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 181 SVTIRHLEQWFFKitdyaerllndldkltgwpehvktmqrnwigkstgaeidfpvEGSDTKIRVFTTRPDTLWGVTFMAL 260
Cdd:PRK12300 153 EPEIVEYTLIKFE------------------------------------------ESEDLILPAATLRPETIFGVTNLWV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 261 APESPLVEELVPEEKKEELQEFLERVKQQDRfrrtSVEAEKE---GFFLGRYAINPVTGERIPIYVANYILMEYGTGAIM 337
Cdd:PRK12300 191 NPDATYVKAEVDGEKWIVSKEAAEKLSFQDR----DVEIIEEikgSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVM 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 338 GVPAHDQRDFSFAKKYG--------IPIKVVIK-------PA-------------DRDLDpEKMEEAYEGE---GIM-VN 385
Cdd:PRK12300 267 SVPAHAPYDYVALRDLKknkelldvIEPIPLIEvegygefPAkevveklgiksqeDPELE-EATKEVYRAEfhkGVLkEN 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 386 SGPFDGTPSSEGIEKVINWLEEKGIG-------------------------------------KRSV------------Q 416
Cdd:PRK12300 346 TGEYAGKPVREAREKITKDLIEKGIAdimyefsnrpvycrcgtecvvkvvkdqwfidysdpewKELAhkaldnmeiipeE 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 417 YK---------LRDWLISRQRYWGAPIP-----II-----------------YCEKCGIVPvpeEDLPVRLpKDVEFLPT 465
Cdd:PRK12300 426 YRkefentidwLKDRACARRRGLGTRLPwdeewIIeslsdstiymayytiahKIREYGIKP---EQLTPEF-FDYVFLGK 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 466 GqsplSFHEGFKRTKCPICGGEAQREtdtmdtfvdsswyflryvnphledkpfepdDVNYWLPVDQYIGGVEHAVLHLLY 545
Cdd:PRK12300 502 G----DPEEVSKKTGIPKEILEEMRE------------------------------EFLYWYPVDWRHSGKDLIPNHLTF 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 546 SRFvtkvlHDLGYlnFDEPF------TNlftqGMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEW 619
Cdd:PRK12300 548 FIF-----NHVAI--FPEEKwprgivVN----GFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADW 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 620 SDAGIEGVHRFIKRLWNtFYTVLPFVKEENTENLVlknstEKELRRKLHSIIKKITEDIEgGFKFNTAI-SGLMELVNHL 698
Cdd:PRK12300 617 REKEVESVRRQLERFYE-LAKELIEIGGEEELRFI-----DKWLLSRLNRIIKETTEAME-SFQTRDAVqEAFYELLNDL 689
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 699 SQYLNSVpqEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQQAWPSYDPKALEvEEVEIAiqingkvrdk 778
Cdd:PRK12300 690 RWYLRRV--GEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDESKID-EEAELA---------- 756
|
890 900 910
....*....|....*....|....*....|....*..
gi 728866913 779 vvvpvdisEEALKRIVLERERVKEYVDGKPIKKFLYV 815
Cdd:PRK12300 757 --------EEYVKRLIEDIREILKVAKIKPKKVYIYV 785
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
2-768 |
1.41e-80 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 277.37 E-value: 1.41e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPkyYALVMfPYP--SGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYD 79
Cdd:PRK05729 7 KTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSIVI-PPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 80 AFGLpAENAAIEK-----GIHPE------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQL 142
Cdd:PRK05729 84 HAGI-ATQMVVERqlaaeGKSRHdlgrekflekvwEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 143 YKNGLAYKKKAAVNWCPKCKTVLANEQV----KDGkcercgtsvtirHLeqWFFKitdYaerllndldkltgwpehvktm 218
Cdd:PRK05729 163 YEKGLIYRGKRLVNWDPKLQTALSDLEVeykeVKG------------KL--WHIR---Y--------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 219 qrnwigkstgaeidfPVEGSDTKIRVFTTRPDTLWGVTFMALAPESplveelvpeekkeelqeflERVKQqdrfrrtsve 298
Cdd:PRK05729 205 ---------------PLADGSDYLVVATTRPETMLGDTAVAVNPED-------------------ERYKH---------- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 299 aekegfFLGRYAINPVTGERIPIyVA-NYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIkpadrDLDpekmeeay 377
Cdd:PRK05729 241 ------LIGKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIM-----DED-------- 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 378 egeGIMV-NSGPFDGTPSSEGIEKVINWLEEKGI-------------GKRS--------------------------VQ- 416
Cdd:PRK05729 301 ---GTINeNPGEYQGLDRFEARKAIVADLEELGLlvkiephthsvghSDRSgvviepylsdqwfvkmkplakpaleaVEn 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 417 ------------------YKLRDWLISRQRYWGAPIPIIYCEKCGIVpVPEEDlpvrlPKDveflptgqsplsfhegfkR 478
Cdd:PRK05729 378 geikfvperwektyfhwmENIQDWCISRQLWWGHRIPAWYDEDGEVY-VGREE-----PEA------------------R 433
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 479 TKCPIcggeaQRETDTMDT-FvdSSWYFlryvnphledkPF-------EPDDVNYWLPVDqyiggvehaVLhllysrfVT 550
Cdd:PRK05729 434 EKALL-----TQDEDVLDTwF--SSALW-----------PFstlgwpeKTEDLKRFYPTS---------VL-------VT 479
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 551 kvlhdlGY--------------LNF--DEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPP 613
Cdd:PRK05729 480 ------GFdiiffwvarmimmgLHFtgQVPFKDVYIHGLVRdEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASP 553
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 614 EKDAEWSDAGIEGVHRFIKRLWNTFYTVLpfVKEENTENLVLKNSTEKEL-----RRKLHSIIKKITEDIEgGFKFNTAI 688
Cdd:PRK05729 554 GRDIRFDEERVEGYRNFANKLWNASRFVL--MNLEGADVGELPDPEELSLadrwiLSRLNRTVAEVTEALD-KYRFDEAA 630
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 689 SGLMELVNH--------LS-QYLNSVPQEEwNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGN----DSLVVqQAWPSY 755
Cdd:PRK05729 631 RALYEFIWNefcdwyleLAkPVLQEAAKRA-TRATLAYVLEQILRLLHPFMPFITEELWQKLAPlgieESIML-APWPEA 708
|
890
....*....|...
gi 728866913 756 DPKALEVEEVEIA 768
Cdd:PRK05729 709 DEAIDEAAEAEFE 721
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
2-776 |
6.91e-77 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 266.92 E-value: 6.91e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYalVMFPYP--SGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYD 79
Cdd:COG0525 5 KTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFT--IVIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 80 afglpaeNAAI-----------EKGIHPE------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQ 136
Cdd:COG0525 83 -------HAGIatqavverqlaEEGKSRHdlgrekflervwEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 137 WIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQV----KDGkcercgtsvtirHLeqWFFKitdYaerllndldkltgwp 212
Cdd:COG0525 156 EVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVeheeVKG------------HL--WHIR---Y--------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 213 ehvktmqrnwigkstgaeidfPVEGSDTKIRVFTTRPDTLWGVTFMALAPESPlveelvpeekkeelqeflervkqqdRF 292
Cdd:COG0525 204 ---------------------PLADGSGYIVVATTRPETMLGDTAVAVHPEDE-------------------------RY 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 293 RRtsveaekegfFLGRYAINPVTGERIPIyVA-NYILMEYGTGAimgV---PAHDQRDFSFAKKYGIPIKVVIkpadrDL 368
Cdd:COG0525 238 KH----------LIGKTVILPLVGREIPI-IAdEYVDPEFGTGA---VkitPAHDPNDFEVGKRHNLPMINIL-----DE 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 369 DpekmeeayegeGIMV-NSGPFDGTPSSEGIEKVINWLEEKGI-------------GKRS-------------------- 414
Cdd:COG0525 299 D-----------GTINeNAGKYRGLDRFEARKAIVADLEELGLlvkvephkhsvghSDRSgtviepylsdqwfvkmkpla 367
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 415 ------VQ-------------------YKLRDWLISRQRYWGAPIPIIYCEKcGIVPVPEEDLpvrlpkdveflptgqsp 469
Cdd:COG0525 368 kpaieaVEdgeikfvperwektyfhwmENIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEP----------------- 429
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 470 lsfhegfkrTKCPICGGEA-QRETDTMDT-FvdSSWYFlryvnphledkPF-------EPDDVNYWLPVDqyiggvehaV 540
Cdd:COG0525 430 ---------EACAKAGSVNlTQDEDVLDTwF--SSALW-----------PFstlgwpeKTEDLKYFYPTS---------V 478
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 541 LhllysrfVTkvlhdlGY--------------LNF--DEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTL 603
Cdd:COG0525 479 L-------VT------GFdiiffwvarmimmgLHFtgEVPFKDVYIHGLVRdEQGRKMSKSKGNVIDPLDLIDKYGADAL 545
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 604 RMYILFMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTENLVLKNSTEKELR---RKLHSIIKKITEDIEg 680
Cdd:COG0525 546 RFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGLDPDPEELSLADRwilSRLNKTIAEVTEALE- 624
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 681 GFKFNTAISGLMELV-NHL-SQYL---------NSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLG----NDS 745
Cdd:COG0525 625 KYRFDEAAQALYDFVwNEFcDWYLelakprlygGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPprkeGES 704
|
890 900 910
....*....|....*....|....*....|....
gi 728866913 746 LVVqQAWPSYDPKAL---EVEEVEIAIQINGKVR 776
Cdd:COG0525 705 IML-APWPEADEELIdeeAEAEFEWLKEVISAIR 737
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
12-620 |
2.95e-76 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 259.26 E-value: 2.95e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 12 KWQEVWEEKKVFYT--PQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENA- 88
Cdd:pfam00133 1 QIYEFWDEQGYFKPelEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 89 ----AIEKGIHPEEWTRKNIN------------TIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKK 152
Cdd:pfam00133 81 ekklGIKEKKTRHKYGREEFRekcrewkmeyadEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 153 AAVNWCPKCKTVLANEQV--KDGKcercGTSVTIRhleqwffkitdyaerllndldkltgwpehvktmqrnwigkstgae 230
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVeyKDVK----GPSIHVA--------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 231 idFPV-EGSDTKIRVFTTRPDTLWGVTFMALAPEsplvEELVPEEKKEELQEFLERVKQQDRFRRTSVEAEKEGFFLGRY 309
Cdd:pfam00133 192 --FPLaDDEGASLVIWTTTPWTLPGNTAVAVNPE----FDYVITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKE 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 310 AINPVTGERIPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPikvVIKPADRDldpekmeeayegeGIMVNSGP- 388
Cdd:pfam00133 266 AIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLE---VINPVDDD-------------GTFTEEAPd 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 389 FDGTPSSEGIEKVINWLEEKGI----------------GKRSVQYKL--------------------------------- 419
Cdd:pfam00133 330 FQGVYRFDARKKIVELLTEKGLllkiepfthsypfcwrSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekry 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 420 -------RDWLISRQRYWGAPIPIIYCEKCGIVPVPEEdlpvrLPKDVEFLPTGQSPLSFHEGFKRTKCPICGGEAQRET 492
Cdd:pfam00133 410 fnwlaniQDWCISRQRWWGHPIPAWVSKDTEEVVCRGE-----LFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDE 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 493 DTMDTFVDS-SWYF--LRYVNPHLED-KPFEPDDVnYWLPVDQYIGGVehavlhllySRFVTKVLHdlgyLNFDEPFTNL 568
Cdd:pfam00133 485 DVLDTWFSSgSWPFstLGWPFVNTEEfKKFFPADM-LLEGSDQTRGWF---------YRMIMLSTA----LTGSVPFKNV 550
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 728866913 569 FTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFmAPPEKDAEWS 620
Cdd:pfam00133 551 LVHGLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 602
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-811 |
2.97e-75 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 263.48 E-value: 2.97e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 1 MKeYRPQEIEKKWQEVWEEKKVFytpQRS-----EKPKYYalvmF----PYPSGTLHVGHVKNYVIGDIVARYKRMRGYN 71
Cdd:COG0060 14 MR-ANLPKREPEILKFWEENDIY---EKSrearaGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 72 VLHPFGYDAFGLPAENAAIEK-GIHPEEWTR---------------KNINTIRGQVKKLGISYDWSREIATCDEEYYK-- 133
Cdd:COG0060 86 VPYVPGWDCHGLPIELKVEKElGIKKKDIEKvgiaefrekcreyalKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsi 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 134 WtqWIFLQLYKNGLAYKKKAAVNWCPKCKTVLAN-----EQVKDgkcercgTSVTIRhleqwfFKITDYAERLLNDldkl 208
Cdd:COG0060 166 W--WALKKLYEKGLLYKGLKPVPWCPRCGTALAEaeveyKDVTS-------PSIYVK------FPVKDEKALLLLE---- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 209 tgwpehvktmqrnwigkstgaeidfpvegsDTKIRVFTTRPDTLWGVTFMALAPESP--LVEelVPEEKK----EELqef 282
Cdd:COG0060 227 ------------------------------DAYLVIWTTTPWTLPANLAVAVHPDIDyvLVE--VTGGERlilaEAL--- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 283 LERVKQQDRFRRTSVEAEKEGFFL-GRYAINP----VTGERI-PIYVANYILMEYGTGAimgV---PAHDQRDFSFAKKY 353
Cdd:COG0060 272 VEAVLKELGIEDYEVLATFKGAELeGLRYEHPfyyvVGYDRAhPVILGDYVTTEDGTGI---VhtaPGHGEDDFEVGKKY 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 354 GIPIkvvIKPAD-----------------RDLDP---EKMEEAyegeGIMVNSG------PFD---GTP------SS--- 395
Cdd:COG0060 349 GLPV---LNPVDddgrfteeaplfaglfvKDANPaiiEDLKER----GALLAREkithsyPHCwrcKTPliyratPQwfi 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 396 ----------EGIEKViNWLEEKG---IGK----RsvqyklRDWLISRQRYWGAPIPIIYCEKCGIVPVPEE------DL 452
Cdd:COG0060 422 smdklrdralEAIEKV-NWIPEWGegrFGNmlenR------PDWCISRQRYWGVPIPIWVCEDCGELHRTEEvigsvaEL 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 453 PVRLPKDVEFlptgqsPLSFHEGF--KRTKCPICGGEAQRETDTMDTFVDS--SWYFLryvnphLEDKPfepddvNYWLP 528
Cdd:COG0060 495 LEEEGADAWF------ELDLHRPFldETLKCPKCGGTMRRVPDVLDVWFDSgsMHFAV------LENRE------ELHFP 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 529 VDQYIGGV-EHavlhllysR--FVTkvLHDLGYLNFDE-PFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTL 603
Cdd:COG0060 557 ADFYLEGSdQT--------RgwFYS--SLLTSTALFGRaPYKNVLTHGFVLdEDGRKMSKSLGNVVDPQEVIDKYGADIL 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 604 RMYILfMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVL-------PfvkeenTENLVLKNSTEkELRR----KLHSIIK 672
Cdd:COG0060 627 RLWVA-SSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLanlddfdP------AEDAVPYEDLP-ELDRwilsRLNELIK 698
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 673 KITEDIEgGFKFNTAISGLME-LVNHLSQ-YL------------NSVpqeewnRKL-----LREIVEKLTLALSPFAPHL 733
Cdd:COG0060 699 EVTEAYD-NYDFHRAYRALHNfCVEDLSNwYLdiskdrlyteaaDSL------DRRaaqttLYEVLETLVRLLAPILPFT 771
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 734 AEEFWHDL-GNDSLVVQQA-WPSYDPKALEvEEVEIAIQingKVRdkvvvpvDISEEALKriVLERERVKEYVdGKPIKK 811
Cdd:COG0060 772 AEEIWQNLpGEAEESVHLAdWPEVDEELID-EELEAKWD---LVR-------EVRSAVLK--ALEAARKEKLI-RQPLEA 837
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
4-777 |
4.81e-73 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 256.15 E-value: 4.81e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 4 YRPQEIEKKWQEVWEEKKVFYT--PQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81
Cdd:TIGR00392 6 GNLSKREEKILAFWQENDIFEKvkKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 82 GLPAENAAIEK-GIHPE----------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYK 144
Cdd:TIGR00392 86 GLPIEHKVEKKlGISGKkeissleieefrekcrEFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 145 NGLAYKKKAAVNWCPKCKTVLANEQV--KDGKCERCGTSVTIRhleqwfFKITDyaERLLNDLDKLTgwpehvktmqrnw 222
Cdd:TIGR00392 166 KGLLYRGLKPVYWSPRCRTALAEAEVeyKENYKDVKDPSIYVK------FPVKK--DKKTYLKVKLS------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 223 igkstgaeidfpvegsdtKIRVFTTRPDTLWGVTFMALAPEspLVEELVPEEKKEE----LQEFLERVKQqdrfrRTSVE 298
Cdd:TIGR00392 225 ------------------SLLIWTTTPWTLPSNLAIAVHPD--FEYALVQDNTKVEyfilAKKLVEKLYN-----KAGSD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 299 AEKEGFFLGR-----------YAINPVTGERIPIYV-ANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPI--------- 357
Cdd:TIGR00392 280 YEIIKTFKGSdlegleyehplYDFVSQLKEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlspvdekgv 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 358 -----------------KVVIKPADRDLDPEKMEEAYEGEGIMVNSGPFD---GTP-------------------SSEGI 398
Cdd:TIGR00392 360 ytegvndfqgrfvkdadKDIIKANKIIIEQLKDKGLLLKAEKITHSYPHCwrtKTPviyrateqwfiktkdikdqMLEQI 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 399 EKViNWLEEKGIGK-RSVQYKLRDWLISRQRYWGAPIPIIYCEKCGIVPVPE--EDLPVRLPK---DVEFLPTgqsplsf 472
Cdd:TIGR00392 440 KKV-NWVPEWGEGRfGNWLENRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGsiEELIELIELkgiDAWFEDL------- 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 473 HEGF--KRTKCPICGGEAQRETDTMDTFVDS--SWYflryvnpHLEDKPFEPDDVNYWLPVDQYIGGVEHaVLHLLYSRF 548
Cdd:TIGR00392 512 HRDFldKITLKSGDGGEYRRVPDVLDVWFDSgsMPY-------ASIHYPFENEKFKEVFPADFILEGSDQ-TRGWFYSSL 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 549 VTKVLhdlgyLNFDEPFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYiLFMAPPEKDAEWSDAGIEGV 627
Cdd:TIGR00392 584 AIGTA-----LFGQAPYKNVITHGFTLdEKGRKMSKSLGNVVDPLKVINKYGADILRLY-VASSDPWEDLRFSDEILKQV 657
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 628 HRFIKR-LWNTF-----YTVLPFVKEENTENLVLKNSTE-KELRRKLHSIIKKITEDIEgGFKFNTAISGLME-LVNHLS 699
Cdd:TIGR00392 658 VEKYRKiRWNTYrflltYANLDKFDPLFNSVAVEKFPEEdRWILSRLNSLVEEVNEALE-KYNFHKVLRALQDfIVEELS 736
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 700 Q-YLNSVPQEEW-----NRKL-----LREIVEKLTLALSPFAPHLAEEFWHDL---GNDSLVVQQAWPSYDPKALEvEEV 765
Cdd:TIGR00392 737 NwYIRIIRDRLYceakdNDKRaaqttLYYALLTLVRLLAPFLPHTAEEIYQNLpggEEEESVHLNLWPEVDEEFID-EAL 815
|
890
....*....|..
gi 728866913 766 EIAIQINGKVRD 777
Cdd:TIGR00392 816 EANMAIVREIVE 827
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
41-616 |
6.24e-70 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 235.60 E-value: 6.24e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAEN-----AAIEKGIHPE-----------EWTRKNI 104
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHDlgreeflekcwEWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 105 NTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVkdgkCERCGTSVTI 184
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 185 RHLEQWFFKITDYAERLlndldkltgwpehvktmqrnwigkstgaeidfpvegsdtkirvfttrpdtlwgvtfmalapes 264
Cdd:cd00817 166 LLKPQWFVKVKDLAKKA--------------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 265 plveelvpeekkeelqefLERVKQQDrfrrtsveaekegfflgryainpvtgeripiyvanyilmeygtgaimgvpahdq 344
Cdd:cd00817 183 ------------------LEAVKEGD------------------------------------------------------ 190
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 345 rdfsfakkygipIKVVikpadrdldPEKMEEAYEgegimvnsgpfdgtpssegiekviNWLEekgigkrsvqyKLRDWLI 424
Cdd:cd00817 191 ------------IKFV---------PERMEKRYE------------------------NWLE-----------NIRDWCI 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 425 SRQRYWGAPIPIIYCEKCG-IVPVPEEDLPVRLPKDVEflptgqsplsfhegfkrtKCPICGGEAQRETDTMDTFVDSS- 502
Cdd:cd00817 215 SRQLWWGHRIPAWYCKDGGhWVVAREEDEAIDKAAPEA------------------CVPCGGEELKQDEDVLDTWFSSSl 276
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 503 WYFlryvnpHLEDKPFEPDDVNYWLPVDQYIGGveHAVLHLLYSRFVTKVLHDLGYLnfdePFTNLFTQGMIY-KDGAKM 581
Cdd:cd00817 277 WPF------STLGWPEETKDLKKFYPTSLLVTG--HDIIFFWVARMIMRGLKLTGKL----PFKEVYLHGLVRdEDGRKM 344
|
570 580 590
....*....|....*....|....*....|....*
gi 728866913 582 SKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKD 616
Cdd:cd00817 345 SKSLGNVIDPLDVIDGYGADALRFTLASAATQGRD 379
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-764 |
5.28e-64 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 232.58 E-value: 5.28e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQR-SEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDA 80
Cdd:PRK14900 17 KGYEHREVEARWYPFWQERGYFHGDEHdRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDH 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 81 FGLpAENAAIEKGIHPEE------------------WTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQL 142
Cdd:PRK14900 97 AGI-ATQMIVEKELKKTEkksrhdlgreaflervwaWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 143 YKNGLAYKKKAAVNWCPKCKTVLANEQVkdgkcercgtsvtirhleqwffkitdyaerllndldkltgwpEHVKTMQRN- 221
Cdd:PRK14900 176 HEEGLIYREKKLINWCPDCRTALSDLEV------------------------------------------EHEEAHQGEl 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 222 WigkstgaEIDFPVEGSDTKIRVFTTRPDTLWGVTFMALAPESPLVEELVpeekkeelqeflervkqqdrfrrtsveaek 301
Cdd:PRK14900 214 W-------SFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYMALH------------------------------ 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 302 egfflGRYAINPVTGERIPIyVANYILME--YGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRdldpekMEEAyeg 379
Cdd:PRK14900 257 -----GKKVRHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGR------MTAE--- 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 380 egimvnSGPFDGTPSSEGIEKVINWLEEKGIGKRSVQYKL---------------------------------------- 419
Cdd:PRK14900 322 ------AGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLplgrcqrsatilepllsdqwyvrieplarpaieaveqgrt 395
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 420 ------------------RDWLISRQRYWGAPIPIIYCEKcGIVPVPEEdlpvrlpkdveflptgqSPLSfhegfkrtkC 481
Cdd:PRK14900 396 rfipeqwtntymawmrniHDWCISRQLWWGHQIPAWYCPD-GHVTVARE-----------------TPEA---------C 448
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 482 PICGG-EAQRETDTMDTFVDSS-WYFLRYVNPHledkpfEPDDVNYWLPVDQYIGGveHAVLHLLYSRFVTKVLHDLGyl 559
Cdd:PRK14900 449 STCGKaELRQDEDVLDTWFSSGlWPFSTMGWPE------QTDTLRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMG-- 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 560 nfDEPFTNLFTQGMIYKD-GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEGVHRFIKRLWNTF 638
Cdd:PRK14900 519 --EVPFRTVYLHPMVRDEkGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNAS 596
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 639 YTVLpfvkeENTENLVLKNSTEKELRRK------LHSIIKKITEDIEG--GFKFNTAISGLMELVNH--------LSQ-- 700
Cdd:PRK14900 597 RFAL-----MNLSGYQERGEDPARLARTpadrwiLARLQRAVNETVEAleAFRFNDAANAVYAFVWHelcdwyieLAKea 671
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 728866913 701 -YLNSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLgnDSLVVQQAWP------SYdPKALEVEE 764
Cdd:PRK14900 672 lASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVL--RAQVGASAWAdsvlaaEY-PRKGEADE 739
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-596 |
1.31e-45 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 177.12 E-value: 1.31e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 1 MKE-YRPQEIEKKWQEVWEEKKvFYTPQRSEKP-----KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLH 74
Cdd:PTZ00419 24 MAAsYDPKEVESGWYEWWEKSG-FFKPAEDAKSlnsgkKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 75 PFGYDAFGLpAENAAIEKGIHPEE------------------WTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQ 136
Cdd:PTZ00419 103 VPGTDHAGI-ATQVVVEKKLMKEEnktrhdlgreeflkkvweWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 137 WIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVkdgkcercgtsvtirhleqwffkitDYAErlLNDLDKLTgWPEHVK 216
Cdd:PTZ00419 182 EAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEV-------------------------EFEE--IEKPTKIT-IPGYDK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 217 TMQRNWIgkstgAEIDFPVEGSDT-KIRVFTTRPDTLWGVTFMALAPESplveelvpeekkeelqeflERVKQqdrfrrt 295
Cdd:PTZ00419 234 KVEVGVL-----WHFAYPLEDSGQeEIVVATTRIETMLGDVAVAVHPKD-------------------ERYKK------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 296 sveaekegfFLGRYAINPVTGERIPIYVANYIL--MEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIkpadrDLDpEKM 373
Cdd:PTZ00419 283 ---------LHGKELIHPFIPDRKIPIIADDELvdMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIF-----TLD-GKI 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 374 EEayegegimvNSGPFDGTPSSEGIEKVINWLEEKG------------------------------------IGKRSVQY 417
Cdd:PTZ00419 348 NE---------NGGEFAGMHRFDCRRKIEEELKEMGllrdkvpnpmrlprcsrsgdivepmlipqwyvnckdMAKRAVEA 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 418 ----------------------KLRDWLISRQRYWGAPIPIIYCEKCGIVPVPEEDLPVRLPKDVEflpTGQSplsfhEG 475
Cdd:PTZ00419 419 vrngelkiipsshenvwyhwleNIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEE---EALE-----KA 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 476 FKRTKCPICGGEAQRETDTMDTFVDSS--------WyflryvnphledkPFEPDDVNYWLPVDQYIGGveHAVLHLLYSR 547
Cdd:PTZ00419 491 KKKFGLSEEDFELEQDEDVLDTWFSSGlfpfstlgW-------------PDQTDDLQRFFPTSLLETG--SDILFFWVAR 555
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 728866913 548 FVTKVLHDLGYLnfdePFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIE 596
Cdd:PTZ00419 556 MVMMSLHLTDKL----PFKTVFLHAMVRdSQGEKMSKSKGNVIDPLEVIE 601
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
619-741 |
1.40e-45 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 158.92 E-value: 1.40e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 619 WSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTENLVlkNSTEKELRRKLHSIIKKITEDIEGgFKFNTAISGLMELVNHL 698
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAAEL--SEEDKELRRKLHKTIKKVTEDIER-LRFNTAIAALMELVNAL 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 728866913 699 SQYLNSVPQeewNRKLLREIVEKLTLALSPFAPHLAEEFWHDL 741
Cdd:cd07958 78 YKYKKKDAQ---HAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
17-804 |
2.48e-43 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 169.74 E-value: 2.48e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 17 WEEKKVFYTPQRSEKPKYYALVMfPYP--SGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLpAENAAIEKGI 94
Cdd:PLN02943 72 WWESQGYFKPNFDRGGDPFVIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI-ATQLVVEKML 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 95 HPE-----------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNW 157
Cdd:PLN02943 150 ASEgikrtdlgrdeftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 158 CPKCKTVLANEQVkdgkcercgtsvtirhleqwffkitDYAERllndldklTGWPEHVKtmqrnwigkstgaeidFPVEG 237
Cdd:PLN02943 230 SPNLQTAVSDLEV-------------------------EYSEE--------PGTLYYIK----------------YRVAG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 238 -SDTKIRVFTTRPDTLWGVTFMALAPESplveelvpeekkeelqeflervkqqDRFRRtsveaekegfFLGRYAINPVTG 316
Cdd:PLN02943 261 gSEDFLTIATTRPETLFGDVAIAVNPED-------------------------DRYSK----------YIGKMAIVPMTY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 317 ER-IPIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKpADRDLDP----------EKMEEAYEGEGIMVN 385
Cdd:PLN02943 306 GRhVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMN-KDGTLNEvaglywfearEKLWSDLEETGLAVK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 386 SGPFD-GTPSS----EGIEKVIN--W------LEEKGIgkRSVQYK-------------------LRDWLISRQRYWGAP 433
Cdd:PLN02943 385 KEPHTlRVPRSqrggEVIEPLVSkqWfvtmepLAEKAL--KAVENGeltiiperfekiynhwlsnIKDWCISRQLWWGHR 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 434 IPIIY-----CEKCGIVPVPEED----LPVRLPKDVEFLptgqsplsfhegfkrtkcpicggeaqRETDTMDTFVDSS-W 503
Cdd:PLN02943 463 IPVWYivgkdCEEDYIVARSAEEalekAREKYGKDVEIY--------------------------QDPDVLDTWFSSAlW 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 504 YFLRYVNPHLedkpfEPDDVNYWLPVDQYIGGveHAVLHLLYSRFVTKVLHDLGYLnfdePFTNLFTQGMIY-KDGAKMS 582
Cdd:PLN02943 517 PFSTLGWPDV-----SAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLIRdSQGRKMS 585
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 583 KSKGNVVSPDEMIEKYGADTLRmYILFMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVL------------------PF 644
Cdd:PLN02943 586 KTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLqnlpsqsdtsawehilacKF 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 645 VKEENTENLVLknsTEKELRRKLHSIIKKITEDIEGGFkFNTAISGLMELV--NHLSQYL------------NSVPQEew 710
Cdd:PLN02943 665 DKEESLLSLPL---PECWVVSKLHELIDSVTTSYDKYF-FGDVGREIYDFFwsDFADWYIeasktrlyhsgdNSALSR-- 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 711 NRKLLREIVEKLTLALSPFAPHLAEEFWHDLGN--DSLVVqQAWPSYD-PKALE-VEEVEIAIQINGKVRDkvvVPVDIS 786
Cdd:PLN02943 739 AQAVLLYVFENILKLLHPFMPFVTEELWQALPYrkEALIV-SPWPQTSlPKDLKsIKRFENLQSLTRAIRN---ARAEYS 814
|
890 900
....*....|....*....|.
gi 728866913 787 EEALKRI---VLERERVKEYV 804
Cdd:PLN02943 815 VEPAKRIsasIVASAEVIEYI 835
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
33-619 |
1.10e-41 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 154.88 E-value: 1.10e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 33 KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIH-------------PEEW 99
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRkkktiwieefredPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 100 TRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVnwcpkcktvlaneqvkdgkcercg 179
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV------------------------ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 180 tsvtiRHLEQWFFKITDYaerllndldkltgwpehvktmqrnwigkstgaeidfpvegsdtkirvfttrpdtlwgvtfma 259
Cdd:cd00668 137 -----RITEQWFFDMPKF-------------------------------------------------------------- 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 260 lapesplveelvpeekKEELQEFLERvkqqdrfrrtsveaekegfflgryainpvtgeripiyvanyilmeygtgaimgv 339
Cdd:cd00668 150 ----------------KEKLLKALRR------------------------------------------------------ 159
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 340 pahdqrdfsfakkygIPIKvvikpadrdldPEKMEEAYEgegimvnsgpfdgtpssegiekviNWLEEkgigkrsvqykL 419
Cdd:cd00668 160 ---------------GKIV-----------PEHVKNRME------------------------AWLES-----------L 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 420 RDWLISRQRYWGAPIPiiycekcgivpvpeedlpvrlpkdveflptgqsplsfhegfkrtkcpicggeaqreTDTMDTFV 499
Cdd:cd00668 179 LDWAISRQRYWGTPLP--------------------------------------------------------EDVFDVWF 202
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 500 DSSWYFLRYVnphleDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSRFVTKVlhdlgyLNFDEPFTNLFTQGMIY-KDG 578
Cdd:cd00668 203 DSGIGPLGSL-----GYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVA------LFGEIPPKNLLVHGFVLdEGG 271
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 728866913 579 AKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAEW 619
Cdd:cd00668 272 QKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
32-754 |
8.27e-39 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 152.19 E-value: 8.27e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 32 PKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQV 111
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 112 KKLGISYD-WSReiaTCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVkDGKCERCGTSVTIrhleqw 190
Cdd:COG0143 81 EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYV-EGTCPKCGAEDAY------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 191 ffkiTDYAERLLNDLDKltgwpehvkTMQRNWIGKSTGAEidfpvegsdtkirvfttrpdtlwgvtfmalapesplveel 270
Cdd:COG0143 151 ----GDQCENCGATLEP---------TELINPRSAISGAP---------------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 271 vPEEKKEElqeflervkqqdRFrrtsveaekegFF-LGRYAinpvtgeripiyvanyilmeygtgaimgvpahdqrdfsf 349
Cdd:COG0143 178 -PELREEE------------HY-----------FFrLSKYQ--------------------------------------- 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 350 akkygipikvvikpadrdldpEKMEEAYEGEGimvnsgpfDGTPssEGIEKVINWLEEKgigkrsvqykLRDWLISRQRY 429
Cdd:COG0143 195 ---------------------DRLLEWIEENP--------DIQP--EVRNEVLSWLKEG----------LQDLSISRDFD 233
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 430 WGAPIP-----IIYcekcgivpvpeedlpvrlpkdVEF-LPTGqsPLSFHEGFkrtkcpicggeaqretdtmdtfvdssw 503
Cdd:COG0143 234 WGIPVPgdpgkVFY---------------------VWFdALIG--YISATKGY--------------------------- 263
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 504 yflryvnphlEDKPFEPDDVNYWLPvdqyigGVEHAVLHllysrFVTK------------VLHDLGYlnfdEPFTNLFTQ 571
Cdd:COG0143 264 ----------ADDRGLPEDFEKYWP------APDTELVH-----FIGKdiirfhaiiwpaMLMAAGL----PLPKKVFAH 318
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 572 GMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKDAE--WSD---------AGIEG--VHR---FIKRLw 635
Cdd:COG0143 319 GFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDfsWEDfvarvnsdlANDLGnlASRtlsMIHKY- 397
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 636 ntFYTVLPFVKEENTEnlvlknstEKELRRKLHSIIKKITEDIEgGFKFNTAISGLMELVNHLSQYLNSvpQEEW----- 710
Cdd:COG0143 398 --FDGKVPEPGELTEA--------DEELLAEAEAALEEVAEAME-AFEFRKALEEIMALARAANKYIDE--TAPWklakd 464
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 728866913 711 -NRKLLR-------EIVEKLTLALSPFAPHLAEEFWHDLGNDSlvVQQAWPS 754
Cdd:COG0143 465 eDPERLAtvlytllEALRILAILLKPFLPETAEKILEQLGLEG--DELTWED 514
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
2-595 |
9.53e-38 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 152.36 E-value: 9.53e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTPQRSEKPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAF 81
Cdd:PLN02381 98 KQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHA 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 82 GLpAENAAIEKGIHPE------------------EWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLY 143
Cdd:PLN02381 178 GI-ATQVVVEKKLMRErhltrhdigreefvsevwKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLY 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 144 KNGLAYKKKAAVNWCPKCKTVLANEQVkdgkcercgtsvtirhleqwffkitDYAERLLNDLDKLTGWPEHVKtmqrnwi 223
Cdd:PLN02381 257 KEGLIYRDIRLVNWDCTLRTAISDVEV-------------------------DYIDIKERTLLKVPGYDKPVE------- 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 224 gksTGAEIDF--PVEGSDTKIRVFTTRPDTLWGVTFMALAPESPLVEELvpeekkeelqeflervkqqdrfrrtsveaek 301
Cdd:PLN02381 305 ---FGVLTSFayPLEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHL------------------------------- 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 302 egffLGRYAINPVTGERIPIyVANYILME--YGTGAIMGVPAHDQRDFSFAKKYGIPIKVVIKPADRdldpekmeeayeg 379
Cdd:PLN02381 351 ----HGKFAVHPFNGRKLPI-ICDAILVDpnFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGK------------- 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 380 egIMVNSGP-FDGTPSSEGIEKVINWLEEKG------------------------------------IGKRSV------- 415
Cdd:PLN02381 413 --INSNGGSeFAGMPRFAAREAVIEALQKKGlyrgaknnemrlglcsrtndvvepmikpqwfvncssMAKQALdaaidge 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 416 ---------QY---------KLRDWLISRQRYWGAPIPIIYCekcgivpVPEEDLPVRLPKDVEFLPTGQSP----LSFH 473
Cdd:PLN02381 491 nkklefipkQYlaewkrwleNIRDWCISRQLWWGHRIPAWYV-------TLEDDQLKELGSYNDHWVVARNEsdalLEAS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 474 EGFKRTKCpicggEAQRETDTMDTFVDSSWYFLRYVNphledKPFEPDDVNYWLPVDQYIGGveHAVLHLLYSRFVTkvl 553
Cdd:PLN02381 564 QKFPGKKF-----ELSQDPDVLDTWFSSGLFPLSVLG-----WPDDTDDLKAFYPTSVLETG--HDILFFWVARMVM--- 628
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 728866913 554 hdLGY-LNFDEPFTNLFTQGMIyKD--GAKMSKSKGNVVSPDEMI 595
Cdd:PLN02381 629 --MGMqLGGDVPFRKVYLHPMI-RDahGRKMSKSLGNVIDPLEVI 670
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-779 |
4.80e-37 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 150.31 E-value: 4.80e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 10 EKKWQEVWEEKKVFytPQRSEKPKYYALVMF---PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAE 86
Cdd:PLN02843 9 EPEIQKLWEENQVY--KRVSDRNNGESFTLHdgpPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 87 -------NAAIEKGIHP-------EEWTRKNINTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKK 152
Cdd:PLN02843 87 lkvlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 153 AAVNWCPKCKTVLANEQvkdgkcercgtsvtirhLEqwffkitdyaerllndldkltgWPE-HVKT-----MQRNWIGKS 226
Cdd:PLN02843 167 KPVHWSPSSRTALAEAE-----------------LE----------------------YPEgHVSKsiyvaFPVVSPSET 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 227 TGAEIDFPVEGSdtKIRVFTTRPDTLWGVTFMALAPE----------SPLVEELVPEEKKEELQEFLErvKQQDRF---- 292
Cdd:PLN02843 208 SPEELEEFLPGL--SLAIWTTTPWTMPANAAVAVNDKlqysvvevqsFSEDESTSGGNKKKRPGNVLK--EQQKLFliva 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 293 --------RRTSVEAEKEGFFLG------RYaINPVTGERIPIYVA-NYILMEYGTGAIMGVPAHDQRDFSFAKKYGIPI 357
Cdd:PLN02843 284 tdlvpaleAKWGVKLVVLKTFPGsdlegcRY-IHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 358 kvvIKPADRD--------------------------LDPEK---MEEAYEgegimvNSGPFD---GTP-----------S 394
Cdd:PLN02843 363 ---LSPVDDAgkfteeagqfsglsvlgegnaavveaLDEAGsllMEEAYG------HKYPYDwrtKKPtifrateqwfaS 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 395 SEG--------IEKViNWLEEKGIGK-RSVQYKLRDWLISRQRYWGAPIPIIYCEKCGIVPVPEEDLP-----VRLP--- 457
Cdd:PLN02843 434 VEGfrqaaldaIDKV-KWIPAQGENRiRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMNEETIAhvksiVAQKgsd 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 458 -----KDVEFLPtgqsplsfhEGFkRTKCPicggEAQRETDTMDTFVDS--SWYFLryvnphLEDKpfepDDVNYwlPVD 530
Cdd:PLN02843 513 awwymDVEDLLP---------EKY-RDKAS----DYEKGTDTMDVWFDSgsSWAGV------LGSR----EGLSY--PAD 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 531 QYIGGVEHavlH--LLYSRFVTKVLHdlgylNFDEPFTNLFTQGMIYKD-GAKMSKSKGNVVSPDEMIE---------KY 598
Cdd:PLN02843 567 LYLEGSDQ---HrgWFQSSLLTSVAT-----KGKAPYKSVLTHGFVLDEkGFKMSKSLGNVVDPRLVIEggknqkqepAY 638
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 599 GADTLRMYIL-------FMAPPEKDAEWSDAgiegvhrfIKRLWNTFYTVLPFVKEENTENLVLKN---STEKELRRKLH 668
Cdd:PLN02843 639 GADVLRLWVAsvdytgdVLIGPQILKQMSDI--------YRKLRGTLRYLLGNLHDWKPDNAVPYEdlpSIDKYALFQLE 710
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 669 SIIKKITEDIEgGFKFNTAISGLMELVN-HLSQ-YLNSVP-------QEEWNRK----LLREIVEKLTLALSPFAPHLAE 735
Cdd:PLN02843 711 NVVNEIEESYD-NYQFFKIFQILQRFTIvDLSNfYLDVAKdrlyvggTTSFTRRscqtVLAAHLLSLLRAIAPILPHLAE 789
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 728866913 736 EFWHDL------GNDSLVVQQAWPSYDPKALEVEEVEIAI-QINGKVRDKV 779
Cdd:PLN02843 790 DAWQNLpfqedgSAAESVFEAGWPTPNEEWLSFPAEDVDFwSLLLEVRDEV 840
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
40-223 |
9.57e-37 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 142.81 E-value: 9.57e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 40 FPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYD 119
Cdd:pfam09334 7 LPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISFD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 120 WSreIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDG------------KCERCGTSV----- 182
Cdd:pfam09334 87 DY--GRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTcphcgsedargdQCENCGRHLeptel 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 728866913 183 ------------TIRHLEQWFFKITDYAERLLNDLDK-LTGWPEHVKTMQRNWI 223
Cdd:pfam09334 165 inpkcvicgttpEVKETEHYFFDLSKFQDKLREWIEEnNPEWPENVKNMVLEWL 218
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
41-223 |
1.07e-36 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 140.74 E-value: 1.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYDw 120
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISFD- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 121 sREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLAneqvkdgkcercgtsvTIRHLEQWFFKITDYAER 200
Cdd:cd00814 88 -YFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYFFRLSKFQDR 150
|
170 180
....*....|....*....|....*
gi 728866913 201 LLNDLDK--LTGWPEHVKTMQRNWI 223
Cdd:cd00814 151 LLEWLEKnpDFIWPENARNEVLSWL 175
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
41-745 |
5.08e-35 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 140.40 E-value: 5.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLhpF--GYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISY 118
Cdd:PRK11893 10 YYPNGKPHIGHAYTTLAADVLARFKRLRGYDVF--FltGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEALNISY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 119 D-WSReiaTCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGK--CERCGTSVTIRHLEQWFFKIT 195
Cdd:PRK11893 88 DdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVEEESYFFRLS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 196 DYAERLLndldkltgwpEHVKTMQrnwigkstgaeiDFpvegsdtkirvfttrpdtlwgvtfmalapesplveeLVPEEK 275
Cdd:PRK11893 165 KYQDKLL----------ELYEANP------------DF------------------------------------IQPASR 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 276 KEELQEFlervkqqdrfrrtsveaekegfflgryainpvtgeripiyvanyilmeygtgaimgvpahdqrdfsfakkygi 355
Cdd:PRK11893 187 RNEVISF------------------------------------------------------------------------- 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 356 pikvvikpadrdldpekmeeayegegimVNSGpfdgtpssegiekvinwleekgigkrsvqykLRDWLISRQRY-WGapi 434
Cdd:PRK11893 194 ----------------------------VKSG-------------------------------LKDLSISRTNFdWG--- 211
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 435 piiycekcgiVPVPEEDlpvrlpkdveflptgqsplsfhegfkrtKCpicggeaqretdTMDTFVDsswYFLRYVNPHL- 513
Cdd:PRK11893 212 ----------IPVPGDP----------------------------KH------------VIYVWFD---ALTNYLTALGy 238
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 514 -EDKPFEPDDVNYWLPVDQYIGGVEHAVLHLLYSrfvTKVLHDLGYlnfdEPFTNLFTQGMIYKDGAKMSKSKGNVVSPD 592
Cdd:PRK11893 239 pDDEELLAELFNKYWPADVHLIGKDILRFHAVYW---PAFLMAAGL----PLPKRVFAHGFLTLDGEKMSKSLGNVIDPF 311
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 593 EMIEKYGADTLRMYILFMAPPEKDAEWSDAGIEG-------------VHRFIKRLWNTFYTVLPFVKEENTENlvlknst 659
Cdd:PRK11893 312 DLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINrinadlandlgnlAQRTLSMIAKNFDGKVPEPGALTEAD------- 384
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 660 eKELRRKLHSIIKKITEDIEgGFKFNTAISGLMELVNHLSQYLNSvpQEEWN-RKLLREIVEK-----------LTLALS 727
Cdd:PRK11893 385 -EALLEAAAALLERVRAAMD-NLAFDKALEAILALVRAANKYIDE--QAPWSlAKTDPERLATvlytllevlrgIAVLLQ 460
|
730
....*....|....*...
gi 728866913 728 PFAPHLAEEFWHDLGNDS 745
Cdd:PRK11893 461 PVMPELAAKILDQLGVEE 478
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
41-616 |
1.84e-34 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 134.67 E-value: 1.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAA----------IEKGIHPEEWTRK-------N 103
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVekelgisgkkDIEKMGIAEFNAKcrefalrY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 104 INTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWcPkcktvlaneqvkdgkcercgtsVT 183
Cdd:cd00818 90 VDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------------------LI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 184 IRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKtmqrnwigkstgaeidfpvegsdtkirvfttrpdtlwgvtfmalape 263
Cdd:cd00818 147 YRATPQWFIRVTKIKDRLLEANDKVNWIPEWVK----------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 264 splveelvpeekkeelqeflervkqqDRFRrtsveaekegfflgryainpvtgeripiyvanyilmeygtgaimgvpahd 343
Cdd:cd00818 180 --------------------------NRFG-------------------------------------------------- 183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 344 qrdfsfakkygipikvvikpadrdldpekmeeayegegimvnsgpfdgtpssegiekviNWLEEkgigkrsvqykLRDWL 423
Cdd:cd00818 184 -----------------------------------------------------------NWLEN-----------RRDWC 193
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 424 ISRQRYWGAPIPIIYCEKCGivpvpeeDLPVRlpkdveflptgqsplsfhegfkrtkcpicggeaqRETDTMDTFVDS-- 501
Cdd:cd00818 194 ISRQRYWGTPIPVWYCEDCG-------EVLVR----------------------------------RVPDVLDVWFDSgs 232
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 502 SWYFlryvnphLEDKPFEPDDVNYWLPVDQYIGGVEHavlhllySR--FVTkvLHDLGYLNFDE-PFTNLFTQGMIY-KD 577
Cdd:cd00818 233 MPYA-------QLHYPFENEDFEELFPADFILEGSDQ-------TRgwFYS--LLLLSTALFGKaPYKNVIVHGFVLdED 296
|
570 580 590
....*....|....*....|....*....|....*....
gi 728866913 578 GAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKD 616
Cdd:cd00818 297 GRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAED 335
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
29-202 |
3.57e-26 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 114.51 E-value: 3.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 29 SEKPKYYalVMFP--YPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINT 106
Cdd:PRK12267 1 MMKKTFY--ITTPiyYPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 107 IRGQVKKLGISYDwsREIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQ-VKDGKCERCGTSVTIR 185
Cdd:PRK12267 79 FKELWKKLDISYD--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQlVDGGKCPDCGREVELV 156
|
170
....*....|....*..
gi 728866913 186 HLEQWFFKITDYAERLL 202
Cdd:PRK12267 157 KEESYFFRMSKYQDRLL 173
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
41-223 |
3.87e-24 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 108.32 E-value: 3.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWtrknINTIRGQVKK----LGI 116
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEEL----IARYHAEHKRdfagFGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 117 SYD-WSReiaTCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNW----------------CPKCKTVLAN----EQ------ 169
Cdd:PRK00133 87 SFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYdpekgmflpdrfvkgtCPKCGAEDQYgdncEVcgatys 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 728866913 170 ---VKDGKCERCGTSVTIRHLEQWFFKITDYAERLLNDLDKLTGWPEHVKTMQRNWI 223
Cdd:PRK00133 164 pteLINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
8-743 |
1.32e-23 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 107.36 E-value: 1.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 8 EIEKKWQEVWEEKKVFYTPQRSEKPKYyALVMF---PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLP 84
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKK-AYIFYdgpPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 85 AEnAAIEK-------------GIHPEEWTRKNI-----NTIRGQVKKLGISYDWSREIATCDEEYYKWTQWIFLQLYKNG 146
Cdd:PTZ00427 155 IE-YEIEKenninkkedilkmGIDVYNEKCRGIvlkysNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNN 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 147 LAYKKKAAVNWCPKCKTVLANEQVKDGKCERCGTSVTIRhleqwFFKITDYA----ERLLNDLDKLTGWPEHVKTMQR-- 220
Cdd:PTZ00427 234 YVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIIS-----FVLCSDFPkveeECNIEEDKQLLGEKYSVLYNNKre 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 221 NWI-GKSTGAEIDFPVEgsDTKIRVFTTRPDTL---------WGVTFMAL----APESPLVEELVPEEKKEELQEFLERV 286
Cdd:PTZ00427 309 NSNnGNNNSTNNVCYAQ--HSEILAWTTTPWTLpsnlalcvnEHFTYLRIhhvkSNRVVIVGECRLEWIMKELKWNVEDL 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 287 KQQDRFRRTSVEAEKE----GFFLGRYAINpvtgERI-PIYVANYILMEYGTGAIMGVPAHDQRDFSFAKKYGI------ 355
Cdd:PTZ00427 387 KIVNRFKGKELKGLRYkplfTNFYEKYNFK----ERAyKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpekn 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 356 ----PI--------------KVVIKPADRDLDPE-KMEEAYEGEGIMVNSGPF---DGTP-------------SSEGIEK 400
Cdd:PTZ00427 463 ifidPLdangyftneveevqNLYIKEADNVIKKKlKNENRLLSNNTIVHSYPFcwrSDTPliyraipawfirvSNSTNEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 401 VIN-----WLEEKGIGKRSVQY--KLRDWLISRQRYWGAPIPIIYCEKCGIVpvpeedLPVRLPKDVEFLPTGQSPLSFH 473
Cdd:PTZ00427 543 VKNnettyWIPAHIKEKKFHNWikDAKDWCISRNRYWGTPIPIWADEKMETV------ICVESIKHLEELSGVKNINDLH 616
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 474 EGF---------KRTKCPicggEAQRETDTMDTFVDSSwyFLRYVNPHLedkPF--EPDDVNYWLPVDQYIGGVEHavlh 542
Cdd:PTZ00427 617 RHFidhieiknpKGKTYP----KLKRIPEVFDCWFESG--SMPYAKVHY---PFstEKEDFHKIFPADFIAEGLDQ---- 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 543 llySRFVTKVLHDLGYLNFDE-PFTNLFTQGMIY-KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYIL-FMAPPEKDAEW 619
Cdd:PTZ00427 684 ---TRGWFYTLLVISTLLFDKaPFKNLICNGLVLaSDGKKMSKRLKNYPDPLYILDKYGADSLRLYLInSVAVRAENLKF 760
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 620 SDagiEGVHRFIKRLWNTFYTVLPFVKEENT-------------ENLVLKNST--EKELRRKLHSIIKKITEDIEgGFKF 684
Cdd:PTZ00427 761 QE---KGVNEVVKSFILPFYHSFRFFSQEVTryeclnkkqflfnTDYIYKNDNimDQWIFSSVQSLTKSVHTEMK-AYKL 836
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 685 NTAISGLMELVNHLSQY---LN------SVPQEEWNRKL--LREIVEKLTLALSPFAPHLAEEFWHDLGN 743
Cdd:PTZ00427 837 YNVLPKLLQFIENLTNWyirLNrdrmrgSLGEENCLQSLctTYRTLHLFTVLMAPFTPFITEYIYQQLRR 906
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
660-790 |
1.51e-20 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 88.61 E-value: 1.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 660 EKELRRKLHSIIKKITEDIEGgFKFNTAISGLME-LVNHLSQ-YLNSVPQEEWN-------RKLLREIVEKLTLALSPFA 730
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYEN-YRFNTAAQALYEfFWNDLSDwYLELIKDRLYGeepdsraQTTLYEVLETLLRLLAPFM 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 728866913 731 PHLAEEFWHDLgndsLVVQQAWPSyDPKALEVEEVEI------AIQINGKVRDKVVVPVDISEEAL 790
Cdd:pfam08264 80 PFITEELWQKE----SIHLAPWPE-DAELEEAELEEAfelrqeIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
2-608 |
1.77e-19 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 94.02 E-value: 1.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 2 KEYRPQEIEKKWQEVWEEKKVFYTP-QRSE-KPKYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYD 79
Cdd:PLN02882 6 KDFSFPKQEEKILSLWSEIDAFKTQlKRTEgLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 80 AFGLPAENaAIEKGIhpeewtrkNInTIRGQVKKLGI--------------SYDWSREIA-------------TCDEEYY 132
Cdd:PLN02882 86 CHGLPVEY-EIDKKL--------GI-KRRDDVLKMGIdkyneecrsivtrySKEWEKTVTrtgrwidfendykTMDPKFM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 133 KWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLAN-------EQVKDgkcercgTSVTIRhleqwfFKITDyaerllnDL 205
Cdd:PLN02882 156 ESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNfeaglnyKDVSD-------PAVMVS------FPIVG-------DP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 206 DK--LTGWPEHVKTMQRNwIGKSTGAEIDFPVEGSDTKIRVFT---TRPDTLWGVTFMALAPESPlveelvpeEKKEELQ 280
Cdd:PLN02882 216 DNasFVAWTTTPWTLPSN-LALCVNPNFTYVKVRNKYTGKVYIvaeSRLSALPTAKPKSKKGSKP--------ENAAEGY 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 281 EFLERVKQQ-----------DRFRRTSVEAEKegfflgryainpvtgeripIYVANYILMEYGTGAIMGVPAHDQRDFSF 349
Cdd:PLN02882 287 EVLAKVPGSslvgkkyeplfDYFSEFSDTAFR-------------------VVADDYVTDDSGTGVVHCAPAFGEDDYRV 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 350 AKKYGIPIKV-----------------------VIKPADRDLdpekmEEAYEGEGIMVNSG------PF---DGTP---- 393
Cdd:PLN02882 348 CLANGIIEKGgnlpvpvdddgcftekvtdfsgrYVKDADKDI-----IAAIKAKGRLVKSGsithsyPFcwrSDTPliyr 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 394 -------SSEGI-EKVI-------------------NWLEEKgigkrsvqyklRDWLISRQRYWGAPIPiIYCEKCGivp 446
Cdd:PLN02882 423 avpswfvKVEEIkDRLLennkqtywvpdyvkekrfhNWLENA-----------RDWAVSRSRFWGTPLP-IWISDDG--- 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 447 vpEEDLPVRLPKDVEFLpTGQSPLSFHEGF-KRTKCPICGGEAQ----RETDTMDTFVDSS---WYFLRYV--NPHLEDK 516
Cdd:PLN02882 488 --EEVVVIGSIAELEKL-SGVKVTDLHRHFiDHITIPSSRGPEFgvlrRVDDVFDCWFESGsmpYAYIHYPfeNKELFEK 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 517 PFEPDDVNYWLpvDQYIGgvehavlhLLYSRFVtkvlhdLGYLNFDEP-FTNLFTQGMIY-KDGAKMSKSKGNVVSPDEM 594
Cdd:PLN02882 565 NFPADFVAEGL--DQTRG--------WFYTLMV------LSTALFDKPaFKNLICNGLVLaEDGKKMSKSLKNYPDPNEV 628
|
730
....*....|....
gi 728866913 595 IEKYGADTLRMYIL 608
Cdd:PLN02882 629 IDKYGADALRLYLI 642
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
619-741 |
3.71e-16 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 75.32 E-value: 3.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 619 WSDAGIEGVhrfIKRLwntfYTVLPFVKE--ENTENLVLKNSTEKELRRKLHSIIKKITEDIEGgFKFNTAI-SGLMELV 695
Cdd:cd07959 1 FREEEANSA---ILRL----ERFYELAEEliETEGELEELTFIDRWLLSRLNRLIKETTEAYEN-MQFREALkEGLYELQ 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 728866913 696 NHLSQYLNSVPQEEwNRKLLREIVEKLTLALSPFAPHLAEEFWHDL 741
Cdd:cd07959 73 NDLDWYRERGGAGM-NKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
8-89 |
3.41e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 67.02 E-value: 3.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 8 EIEKKWQEVWEEKKVFYT--PQRSEKP--KYYALVMFPYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGL 83
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeaGDEPPKPgeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*.
gi 728866913 84 PAENAA 89
Cdd:PLN02959 97 PIKASA 102
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
572-720 |
8.20e-11 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 65.12 E-value: 8.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 572 GMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILfMAPPEKDAEWSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTE 651
Cdd:COG0215 257 GFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLL-SAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAADSS 335
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 728866913 652 NLVLKNSTEKelrrklhsIIKKITEDieggfkFNT--AISGLMELVNHLSQYLNSVPQEEWNRKLLREIVE 720
Cdd:COG0215 336 AEEIEELREE--------FIAAMDDD------FNTpeALAVLFELVREINKALDEGEDKAALAALAALLRA 392
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
568-742 |
9.59e-11 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 65.51 E-value: 9.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 568 LFTQGMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILfmappeKDAEWSDAGIEGVHRFIK--------RLWNTFY 639
Cdd:PLN02224 354 VFGHGFLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFL------REVEFGNDGDYSEDRFIKivnahlanTIGNLLN 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 640 TVLPFVKEENTENLVLKNSTEKE---LRRKLHSIIKKITEDIEgGFKFNTAISGLMELVNHLSQYLNS-----------V 705
Cdd:PLN02224 428 RTLGLLKKNCESTLVEDSTVAAEgvpLKDTVEKLVEKAQTNYE-NLSLSSACEAVLEIGNAGNTYMDQrapwflfkqggV 506
|
170 180 190
....*....|....*....|....*....|....*....
gi 728866913 706 PQEEWNRKL--LREIVEKLTLALSPFAPHLAEEFWHDLG 742
Cdd:PLN02224 507 SAEEAAKDLviILEVMRVIAVALSPIAPCLSLRIYSQLG 545
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
41-179 |
6.77e-10 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 62.88 E-value: 6.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVI-GDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKnINTIRGQVKK-LGISY 118
Cdd:PLN02610 26 PYVNNVPHLGNIIGCVLsADVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDK-YHAIHKEVYDwFDISF 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 728866913 119 D-WSReiaTCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVkDGKCERCG 179
Cdd:PLN02610 105 DkFGR---TSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLV-EGTCPTEG 162
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
577-729 |
1.67e-09 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 61.20 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 577 DGAKMSKSKGNVVSPDEMIEKYGADTLRMyiLFMAPPEKDA-EWSDAGIEGVHRFIKRLWNTFYTVLPFVKEENTENLVL 655
Cdd:PTZ00399 312 KGLKMSKSLKNFITIRQALSKYTARQIRL--LFLLHKWDKPmNYSDESMDEAIEKDKVFFNFFANVKIKLRESELTSPQK 389
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 728866913 656 KNSTEKELRRKLHSIIKKITEDIEGGFKFNTAISGLMELVNHLSQYLNSvpQEEWNRKLLREIVEKLTLALSPF 729
Cdd:PTZ00399 390 WTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNS--GEQPSAPLLRSVAQYVTKILSIF 461
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
620-771 |
2.47e-08 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 54.48 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 620 SDAGIEGVHR-FIKRLWNTFYTVLPFVK--EENTENLVLKNSTEKELRR----KLHSIIKKITEDIEGgFKFNTAISGLM 692
Cdd:cd07961 2 SEKGVREVVRkVLLPLWNAYRFFVTYANldGFDPGKDDDAVASLNVLDRwilsRLNSLIKEVTEEMEA-YDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 693 ELVNHLSqylNsvpqeeW----NRKLLR----------------EIVEKLTLALSPFAPHLAEEFWHDLGNDSLVVQ--- 749
Cdd:cd07961 81 EFIDELT---N------WyirrNRKRFWgeegdddklaayatlyEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPesv 151
|
170 180
....*....|....*....|....*...
gi 728866913 750 --QAWPSYDP----KALEvEEVEIAIQI 771
Cdd:cd07961 152 hlLDWPEVDEslidEELE-EAMELVREI 178
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
627-738 |
1.27e-06 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 48.25 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 627 VHRFIKRLWNTFYTVLPFVKEENTEnlvlknstEKELRRKLHSIIKKITEDIEGgFKFNTAISGLMELVNHLSQYLNSvp 706
Cdd:cd07957 13 VNRTLNMASKYFGGVVPEFGGLTEE--------DEELLEEAEELLEEVAEAMEE-LEFRKALEEIMELARAANKYIDE-- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 728866913 707 QEEW------NRKLLR-------EIVEKLTLALSPFAPHLAEEFW 738
Cdd:cd07957 82 TAPWklakeeDPERLAtvlyvllELLRILAILLSPFMPETAEKIL 126
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
623-730 |
1.61e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 47.50 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 623 GIEGVHRFIKRLWNTfytVLPFVKEENTENLVLKNST----EKELRRKLHSIIKKITEDIEGgFKFNTAISGLMELVNHL 698
Cdd:cd07375 3 RLKQARAFLNRLYRL---LSFFRKALGGTQPKWDNELleeaDRELLARLQEFIKRTTNALEA-LDPTTAVQELFKFTNEL 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 728866913 699 SQYLNSVPQEEWN-------RKLLREIVEKLTLALSPFA 730
Cdd:cd07375 79 NWYLDELKPALQTeelreavLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
624-741 |
3.62e-06 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 47.17 E-value: 3.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 624 IEGVHRFIKRLWNTFYTVLPFVKEENTENLVLKNST--EKELRRKLHSIIKKITEDIEGgFKFNTAISGLMELVNHL--S 699
Cdd:cd07962 6 VEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPESLSlaDRWILSRLNKTVEEVTEALEN-YRFSEAATALYEFFWNDfcD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 728866913 700 QYL---------NSVPQEEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDL 741
Cdd:cd07962 85 WYLelvkprlygEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
561-608 |
4.78e-06 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 48.34 E-value: 4.78e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 728866913 561 FDEPFTNLFTQ-GMIYKDGAKMSKSKGNVVSPDEMIEKYGADTLRMYIL 608
Cdd:cd00672 154 TGKPFARYWLHtGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
41-111 |
2.18e-05 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 45.16 E-value: 2.18e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQV 111
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDV 76
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
42-201 |
2.84e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.79 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 42 YPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKGIHPEEWTRKNINTIRGQVKKLGISYDws 121
Cdd:PLN02224 79 YVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYRTLWKDLDIAYD-- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 122 REIATCDEEYYKWTQWIFLQLYKNGLAYKKKAAVNWCPKCKTVLANEQVKDGKCerCGT---SVTIRHLEQWFFKITDYA 198
Cdd:PLN02224 157 KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CPVhqmPCVARKEDNYFFALSKYQ 234
|
...
gi 728866913 199 ERL 201
Cdd:PLN02224 235 KPL 237
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
41-155 |
4.65e-05 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 45.25 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 41 PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGlpaeNAAIEKGIHPEEWTRKNINTIRGQ---VKKLGIS 117
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVTREYYINDWG----RQIGLLILSLEKWRKLVEESIKADletYGRLDVR 84
|
90 100 110
....*....|....*....|....*....|....*....
gi 728866913 118 YD-WSREiatcdEEYYKWTQWIFLQLYKNGLAYKKKAAV 155
Cdd:cd00671 85 FDvWFGE-----SSYLGLMGKVVELLEELGLLYEEDGAL 118
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
6-95 |
5.53e-05 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 46.57 E-value: 5.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 6 PQEIEKKWQEVWEEKKVFYTPQRSEKPKyyALVMF--PYPSGTLHVGHVKNYVIGDIVARYKRMRGYNV----------- 72
Cdd:TIGR00456 86 PQKLLERLIQKILTQKEKYGSKKLKNKK--IIIEFssANPAGPLHVGHLRNAIIGDSLARILEFLGYDVireyyvndwgr 163
|
90 100
....*....|....*....|....*.
gi 728866913 73 ---LHPFGYDAFGLPAENAAIEKGIH 95
Cdd:TIGR00456 164 qfgLLALGVEKFGNEALNIAVKKPDH 189
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
572-607 |
1.05e-04 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 45.57 E-value: 1.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 728866913 572 GMIY-----KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYI 607
Cdd:PRK00750 267 PFVYelfldKKGEKISKSKGNVITIEDWLEYAPPESLRLFM 307
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
666-779 |
3.00e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 42.51 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728866913 666 KLHSIIKKITEDIEGgFKFNTAISGLMELVNHL--SQYLNSV-------PQEEWNRK----LLREIVEKLTLALSPFAPH 732
Cdd:cd07960 52 RLNELIKEVREAYEN-YEFHKVYQALNNFCTVDlsAFYLDIIkdrlycdAKDSLERRsaqtVLYHILDALLKLLAPILPF 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 728866913 733 LAEEFW----HDLGNDSlVVQQAWPSYDPKALEVEEVEiAIQINGKVRDKV 779
Cdd:cd07960 131 TAEEVWehlpGEKKEES-VFLEDWPELPEEWKDEELEE-KWEKLLALRDEV 179
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
576-615 |
5.99e-04 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 43.02 E-value: 5.99e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 728866913 576 KDGAKMSKSKGNVVSPDEMIEKYGADTLRmYILFMAPPEK 615
Cdd:pfam01921 275 KGGGKMSSSKGNVITPEDWLEYAPPESLR-FLMFRTKPKK 313
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
572-608 |
7.88e-04 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 42.87 E-value: 7.88e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 728866913 572 GMIY-----KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYIL 608
Cdd:COG1384 274 GFVYelfldENGEKISKSKGNGLTVEEWLEYAEPESLRYFMF 315
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
48-116 |
9.65e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 42.40 E-value: 9.65e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 728866913 48 HVGHVKNYVIGDIVARYKRMRGYNVLHpfgydafglpAEN----------AAIEKGIHPEEWTRKNINTIRGQVKKLGI 116
Cdd:COG0215 37 HIGHARTFVVFDVLRRYLRYLGYKVTY----------VRNitdvddkiikRAAEEGESIWELAERYIAAFHEDMDALGV 105
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
576-616 |
3.67e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 40.39 E-value: 3.67e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 728866913 576 KDGAKMSKSKGNVVSPDEMIEKYGADTLRMYILFMAPPEKD 616
Cdd:cd00674 271 KGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPEKH 311
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
43-72 |
5.23e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 40.14 E-value: 5.23e-03
10 20 30
....*....|....*....|....*....|
gi 728866913 43 PSGTLHVGHVKNYVIGDIVARYKRMRGYNV 72
Cdd:PRK01611 122 PTGPLHVGHLRSAVIGDALARILEFAGYDV 151
|
|
| |
