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Conserved domains on  [gi|728055225]
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Chain A, Lectin

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_Ricin_MytiLec-like cd23417
ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin ...
 6-139 6.98e-45

ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin (MytiLec) and similar proteins; MytiLec is a D-galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types. It has hemagglutinating activity towards rabbit erythrocytes. It induces glycan-mediated cytotoxicity of human globotriaosylceramide-expressing lymphoma cells. The family also includes lectin from the mussel Mytilus californianus (MCL) and lectin from the sea mussel Crenomytilus grayanus (CGL). MCL is specific for binding D-galactose and N-Acetyl-d-galactosamine that contained carbohydrate moieties that were also inhibited by melibiose and raffinose. It can agglutinate all types of human erythrocytes, as well as rabbit red blood cells. CGL is specific for binding GalNAc/Gal-containing carbohydrate moieties. It displays antibacterial, antifungal, and antiviral activities. It also possesses anti-cancer activity through recognizing globotriose Gb3. Members of this family contain a ricin B-type lectin domain with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


:

Pssm-ID: 467296  Cd Length: 132  Bit Score: 143.63  E-value: 6.98e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728055225   6 TFLIKHKASGKFLHPKGGSSNPANDTNLVLHSDIHE-RMYFQFDVvderWGYIKHAASGKIVHPLGGKADppNETKLVLH 84
Cdd:cd23417    2 PGSIRHKASGKCIHPKGGSCNPPDGTKLVLYSDCSEdRMEFQLDS----DGYLKHVCSGKCVCPKGGSAD--NGTKLVLH 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 728055225  85 QDRH-DRALFAMDfFNDNIIHKA-GKYVHPKGGSTNPPNETLTVMHGD-KHGAMEFIF 139
Cdd:cd23417   76 SNCGdDRAKFRRT-SKGSLQHKSsGKCVHPKGGSPNPSNGTKLVLWSGcDEDRLKFIF 132
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_MytiLec-like cd23417
ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin ...
 6-139 6.98e-45

ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin (MytiLec) and similar proteins; MytiLec is a D-galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types. It has hemagglutinating activity towards rabbit erythrocytes. It induces glycan-mediated cytotoxicity of human globotriaosylceramide-expressing lymphoma cells. The family also includes lectin from the mussel Mytilus californianus (MCL) and lectin from the sea mussel Crenomytilus grayanus (CGL). MCL is specific for binding D-galactose and N-Acetyl-d-galactosamine that contained carbohydrate moieties that were also inhibited by melibiose and raffinose. It can agglutinate all types of human erythrocytes, as well as rabbit red blood cells. CGL is specific for binding GalNAc/Gal-containing carbohydrate moieties. It displays antibacterial, antifungal, and antiviral activities. It also possesses anti-cancer activity through recognizing globotriose Gb3. Members of this family contain a ricin B-type lectin domain with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467296  Cd Length: 132  Bit Score: 143.63  E-value: 6.98e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728055225   6 TFLIKHKASGKFLHPKGGSSNPANDTNLVLHSDIHE-RMYFQFDVvderWGYIKHAASGKIVHPLGGKADppNETKLVLH 84
Cdd:cd23417    2 PGSIRHKASGKCIHPKGGSCNPPDGTKLVLYSDCSEdRMEFQLDS----DGYLKHVCSGKCVCPKGGSAD--NGTKLVLH 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 728055225  85 QDRH-DRALFAMDfFNDNIIHKA-GKYVHPKGGSTNPPNETLTVMHGD-KHGAMEFIF 139
Cdd:cd23417   76 SNCGdDRAKFRRT-SKGSLQHKSsGKCVHPKGGSPNPSNGTKLVLWSGcDEDRLKFIF 132
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_MytiLec-like cd23417
ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin ...
 6-139 6.98e-45

ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin (MytiLec) and similar proteins; MytiLec is a D-galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types. It has hemagglutinating activity towards rabbit erythrocytes. It induces glycan-mediated cytotoxicity of human globotriaosylceramide-expressing lymphoma cells. The family also includes lectin from the mussel Mytilus californianus (MCL) and lectin from the sea mussel Crenomytilus grayanus (CGL). MCL is specific for binding D-galactose and N-Acetyl-d-galactosamine that contained carbohydrate moieties that were also inhibited by melibiose and raffinose. It can agglutinate all types of human erythrocytes, as well as rabbit red blood cells. CGL is specific for binding GalNAc/Gal-containing carbohydrate moieties. It displays antibacterial, antifungal, and antiviral activities. It also possesses anti-cancer activity through recognizing globotriose Gb3. Members of this family contain a ricin B-type lectin domain with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467296  Cd Length: 132  Bit Score: 143.63  E-value: 6.98e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728055225   6 TFLIKHKASGKFLHPKGGSSNPANDTNLVLHSDIHE-RMYFQFDVvderWGYIKHAASGKIVHPLGGKADppNETKLVLH 84
Cdd:cd23417    2 PGSIRHKASGKCIHPKGGSCNPPDGTKLVLYSDCSEdRMEFQLDS----DGYLKHVCSGKCVCPKGGSAD--NGTKLVLH 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 728055225  85 QDRH-DRALFAMDfFNDNIIHKA-GKYVHPKGGSTNPPNETLTVMHGD-KHGAMEFIF 139
Cdd:cd23417   76 SNCGdDRAKFRRT-SKGSLQHKSsGKCVHPKGGSPNPSNGTKLVLWSGcDEDRLKFIF 132
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 5-121 6.40e-06

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 43.13  E-value: 6.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728055225   5 ATFLIKHKASGKFLHPKGGSSnpANDTNLVLHS-DIHERMYFQFDVVDERWGYIKHAASGKIVHPLGGKADppNETKLVL 83
Cdd:cd00161    1 GTYRIVNAASGKCLDVAGGST--ANGAPVQQWTcNGGANQQWTLTPVGDGYYTIRNVASGKCLDVAGGSTA--NGANVQQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 728055225  84 HQDRHDRA-LFAMDFFNDN---IIHKA-GKYVHPKGGSTNPPN 121
Cdd:cd00161   77 WTCNGGDNqQWRLEPVGDGyyrIVNKHsGKCLDVSGGSTANGA 119
beta-trefoil_Ricin_MytiLec-like cd23417
ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin ...
 102-141 1.21e-05

ricin B-type lectin domain, beta-trefoil fold, found in Mytilus galloprovincialis lectin (MytiLec) and similar proteins; MytiLec is a D-galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types. It has hemagglutinating activity towards rabbit erythrocytes. It induces glycan-mediated cytotoxicity of human globotriaosylceramide-expressing lymphoma cells. The family also includes lectin from the mussel Mytilus californianus (MCL) and lectin from the sea mussel Crenomytilus grayanus (CGL). MCL is specific for binding D-galactose and N-Acetyl-d-galactosamine that contained carbohydrate moieties that were also inhibited by melibiose and raffinose. It can agglutinate all types of human erythrocytes, as well as rabbit red blood cells. CGL is specific for binding GalNAc/Gal-containing carbohydrate moieties. It displays antibacterial, antifungal, and antiviral activities. It also possesses anti-cancer activity through recognizing globotriose Gb3. Members of this family contain a ricin B-type lectin domain with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467296  Cd Length: 132  Bit Score: 42.33  E-value: 1.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 728055225 102 IIHKA-GKYVHPKGGSTNPPNETLTVMHGD-KHGAMEFIFVS 141
Cdd:cd23417    5 IRHKAsGKCIHPKGGSCNPPDGTKLVLYSDcSEDRMEFQLDS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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