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Conserved domains on  [gi|728048795|sp|E9QYP0|]
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RecName: Full=L-ornithine N(5)-monooxygenase; Short=OMO; AltName: Full=L-ornithine N(5)-oxygenase; AltName: Full=Siderophore biosynthesis protein A

Protein Classification

lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein( domain architecture ID 12141762)

lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein similar to L-ornithine N(5)-monooxygenase that catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores such as ornibactin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
38-409 3.55e-143

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


:

Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 414.29  E-value: 3.55e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795   38 ELHDLLCVGFGPASLAIAIALHDaldprlnksasniHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRS 117
Cdd:pfam13434   1 QIHDLIGIGIGPFNLSLAALLEE-------------IPELDALFFERQPEFAWHPGMLLPGATMQTSFLKDLVTLRDPTS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  118 SFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSssvvDFFTVRSRNvETGE 197
Cdd:pfam13434  68 PFSFLNYLHEHGRLYSFYNLETFFPSRREFNDYLQWAASHLPNRLRFGQEVESVEPDAERGE----PLLRVRVRD-ADGE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  198 ISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSkpynIAVLGSGQSAAEIFHDLQKRYPNSRTTLI 277
Cdd:pfam13434 143 ETTFLARNLVLGTGGEPYIPECARGGERVFHSSEYLERIDRLAAKKR----IAVVGSGQSAAEIFRDLLRRGPAYELTWV 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  278 MRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNpdetQWQHRIL 357
Cdd:pfam13434 219 TRSPNFFPLDDSPFVNEIFSPEYVDYFYSLPEDTRRALLREQKGTNYDGIDPSLIEEIYRLLYEQRVDG----DPRHRLL 294
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 728048795  358 PERKITRVEHHGPQsrmRIHLKSSKPESEGAandvkETLEVDALMVATGYNR 409
Cdd:pfam13434 295 PNREVQSAERVGDG---GVELTLRDGEQGRE-----ETLETDVVVLATGYRR 338
 
Name Accession Description Interval E-value
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
38-409 3.55e-143

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 414.29  E-value: 3.55e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795   38 ELHDLLCVGFGPASLAIAIALHDaldprlnksasniHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRS 117
Cdd:pfam13434   1 QIHDLIGIGIGPFNLSLAALLEE-------------IPELDALFFERQPEFAWHPGMLLPGATMQTSFLKDLVTLRDPTS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  118 SFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSssvvDFFTVRSRNvETGE 197
Cdd:pfam13434  68 PFSFLNYLHEHGRLYSFYNLETFFPSRREFNDYLQWAASHLPNRLRFGQEVESVEPDAERGE----PLLRVRVRD-ADGE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  198 ISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSkpynIAVLGSGQSAAEIFHDLQKRYPNSRTTLI 277
Cdd:pfam13434 143 ETTFLARNLVLGTGGEPYIPECARGGERVFHSSEYLERIDRLAAKKR----IAVVGSGQSAAEIFRDLLRRGPAYELTWV 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  278 MRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNpdetQWQHRIL 357
Cdd:pfam13434 219 TRSPNFFPLDDSPFVNEIFSPEYVDYFYSLPEDTRRALLREQKGTNYDGIDPSLIEEIYRLLYEQRVDG----DPRHRLL 294
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 728048795  358 PERKITRVEHHGPQsrmRIHLKSSKPESEGAandvkETLEVDALMVATGYNR 409
Cdd:pfam13434 295 PNREVQSAERVGDG---GVELTLRDGEQGRE-----ETLETDVVVLATGYRR 338
IucD COG3486
Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport and catabolism] ...
35-485 4.05e-129

Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442709 [Multi-domain]  Cd Length: 440  Bit Score: 382.59  E-value: 4.05e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  35 PQDELHDLLCVGFGPASLAIAIALHDAldPRLNKsasnihaqpkiCFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRD 114
Cdd:COG3486    2 DDTKVYDLIGIGIGPFNLGLAALLDEL--PDLDA-----------LFLERKPEFDWHPGMLLEGATLQVPFLKDLVTLAD 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 115 PRSSFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDvVAYGEEVVEVIPGKSDpsssvvDFFTVRSRNvE 194
Cdd:COG3486   69 PTSPFSFLNYLKEHGRLYDFYNRENFFPLRREYNDYCRWAAEQLDN-VRFGTEVEAVEYDDDA------GAFRVTVRD-G 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 195 TGEISARRTRKVVIAIGGTAKMPSGLP--QDPRIIHSSKYCTTLPALLKDKSkpynIAVLGSGQSAAEIFHDLQKRYPNS 272
Cdd:COG3486  141 TGERETYRARNLVLGTGTRPYLPECFRglPGERVFHSSEYLHRKEDLQAAKR----VTVVGSGQSAAEIFLDLLRRQDGP 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 273 RTTL--IMRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRsLLADKATNYSVVRLELIEEIYNDMYLQRVKNPDEt 350
Cdd:COG3486  217 GAELtwVTRSPGFFPLDYSKFTNEIFSPEYVDYFYALPEEVRDR-LLAEQKLLYKGISPDLINEIYDLLYERSVGGDPP- 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 351 qwQHRILPERKITRVEHHGpqSRMRIHLKSSkpesegaANDVKETLEVDALMVATGYnRNAHERLLSKVQH-LRPTGQDQ 429
Cdd:COG3486  295 --RVRLLPNSEVTAVERAG--GGYRLTLRHL-------ETGERFELETDAVVLATGY-RPRLPAFLEPLADrIRRDEDGR 362
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 728048795 430 WKPHRDYRVEMDPSKvssEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGE 485
Cdd:COG3486  363 LRVDRDYRVDWDGPR---TGRIFVQNAEEHTHGIAAPDLSLGAWRNAVIINSLLGR 415
 
Name Accession Description Interval E-value
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
38-409 3.55e-143

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 414.29  E-value: 3.55e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795   38 ELHDLLCVGFGPASLAIAIALHDaldprlnksasniHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRS 117
Cdd:pfam13434   1 QIHDLIGIGIGPFNLSLAALLEE-------------IPELDALFFERQPEFAWHPGMLLPGATMQTSFLKDLVTLRDPTS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  118 SFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSssvvDFFTVRSRNvETGE 197
Cdd:pfam13434  68 PFSFLNYLHEHGRLYSFYNLETFFPSRREFNDYLQWAASHLPNRLRFGQEVESVEPDAERGE----PLLRVRVRD-ADGE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  198 ISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSkpynIAVLGSGQSAAEIFHDLQKRYPNSRTTLI 277
Cdd:pfam13434 143 ETTFLARNLVLGTGGEPYIPECARGGERVFHSSEYLERIDRLAAKKR----IAVVGSGQSAAEIFRDLLRRGPAYELTWV 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  278 MRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNpdetQWQHRIL 357
Cdd:pfam13434 219 TRSPNFFPLDDSPFVNEIFSPEYVDYFYSLPEDTRRALLREQKGTNYDGIDPSLIEEIYRLLYEQRVDG----DPRHRLL 294
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 728048795  358 PERKITRVEHHGPQsrmRIHLKSSKPESEGAandvkETLEVDALMVATGYNR 409
Cdd:pfam13434 295 PNREVQSAERVGDG---GVELTLRDGEQGRE-----ETLETDVVVLATGYRR 338
IucD COG3486
Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport and catabolism] ...
35-485 4.05e-129

Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442709 [Multi-domain]  Cd Length: 440  Bit Score: 382.59  E-value: 4.05e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  35 PQDELHDLLCVGFGPASLAIAIALHDAldPRLNKsasnihaqpkiCFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRD 114
Cdd:COG3486    2 DDTKVYDLIGIGIGPFNLGLAALLDEL--PDLDA-----------LFLERKPEFDWHPGMLLEGATLQVPFLKDLVTLAD 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 115 PRSSFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDvVAYGEEVVEVIPGKSDpsssvvDFFTVRSRNvE 194
Cdd:COG3486   69 PTSPFSFLNYLKEHGRLYDFYNRENFFPLRREYNDYCRWAAEQLDN-VRFGTEVEAVEYDDDA------GAFRVTVRD-G 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 195 TGEISARRTRKVVIAIGGTAKMPSGLP--QDPRIIHSSKYCTTLPALLKDKSkpynIAVLGSGQSAAEIFHDLQKRYPNS 272
Cdd:COG3486  141 TGERETYRARNLVLGTGTRPYLPECFRglPGERVFHSSEYLHRKEDLQAAKR----VTVVGSGQSAAEIFLDLLRRQDGP 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 273 RTTL--IMRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRsLLADKATNYSVVRLELIEEIYNDMYLQRVKNPDEt 350
Cdd:COG3486  217 GAELtwVTRSPGFFPLDYSKFTNEIFSPEYVDYFYALPEEVRDR-LLAEQKLLYKGISPDLINEIYDLLYERSVGGDPP- 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 351 qwQHRILPERKITRVEHHGpqSRMRIHLKSSkpesegaANDVKETLEVDALMVATGYnRNAHERLLSKVQH-LRPTGQDQ 429
Cdd:COG3486  295 --RVRLLPNSEVTAVERAG--GGYRLTLRHL-------ETGERFELETDAVVLATGY-RPRLPAFLEPLADrIRRDEDGR 362
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 728048795 430 WKPHRDYRVEMDPSKvssEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGE 485
Cdd:COG3486  363 LRVDRDYRVDWDGPR---TGRIFVQNAEEHTHGIAAPDLSLGAWRNAVIINSLLGR 415
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
142-408 5.97e-07

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 51.79  E-value: 5.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 142 PARLEFEDYMRWCAQQFsDV---VAYGEEVVEVIPGKSDPSssvvdfFTVRsrnVETGEisARRTRKVVIAIGG--TAKM 216
Cdd:COG2072   77 PTGDEILAYLEAYADKF-GLrrpIRFGTEVTSARWDEADGR------WTVT---TDDGE--TLTARFVVVATGPlsRPKI 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 217 PSGLPQDP---RIIHSSKYCTtlPALLKDKskpyNIAVLGSGQSAAEIFHDLQKRypNSRTTLIMRdsamRPSDDSPFVN 293
Cdd:COG2072  145 PDIPGLEDfagEQLHSADWRN--PVDLAGK----RVLVVGTGASAVQIAPELARV--AAHVTVFQR----TPPWVLPRPN 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795 294 eiFNPERVdkfysqSAAERQRSLLADKATNYSVVRL--ELIEEIYNDMYLQRVKnPDETQWQHRILPERK---------- 361
Cdd:COG2072  213 --YDPERG------RPANYLGLEAPPALNRRDARAWlrRLLRAQVKDPELGLLT-PDYPPGCKRPLLSTDyyealrrgnv 283
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 728048795 362 ------ITRVEHHGpqsrmrIHLKSskpeseGaandvkETLEVDALMVATGYN 408
Cdd:COG2072  284 elvtggIERITEDG------VVFAD------G------TEHEVDVIVWATGFR 318
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
134-302 8.75e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 41.53  E-value: 8.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  134 FTNLSTFLPARLEFEDYMRWCAQQFSDVVA-----YGEEVVEVIPGKSdpsssvvdffTVRSRNVETGEISARRTRKVVI 208
Cdd:pfam07992  46 LLGAAEAPEIASLWADLYKRKEEVVKKLNNgievlLGTEVVSIDPGAK----------KVVLEELVDGDGETITYDRLVI 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728048795  209 AIGGTAKMPsGLPQDPR-IIHSSKYCTTLPALlKDKSKPYNIAVLGSGQSA---AEIFHDLQKrypnsRTTLI-MRDSAM 283
Cdd:pfam07992 116 ATGARPRLP-PIPGVELnVGFLVRTLDSAEAL-RLKLLPKRVVVVGGGYIGvelAAALAKLGK-----EVTLIeALDRLL 188
                         170       180
                  ....*....|....*....|.
gi 728048795  284 RPSDD--SPFVNEIFNPERVD 302
Cdd:pfam07992 189 RAFDEeiSAALEKALEKNGVE 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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