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Conserved domains on  [gi|727526898|ref|XP_010438882|]
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PREDICTED: zinc finger CCCH domain-containing protein 48 [Camelina sativa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-429 2.99e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVLN-LCGEVGCM-IS-EGPWLLVG-MPNLVK 213
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVaFSpDGKTLASGsADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 214 AWNIQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTscfdPAASLKGHTLAVVSLYVGAN--RLYS 288
Cdd:COG2319  146 LWDLATGKLLrTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 289 GAMDNVIKVWSLDNLQCIQTLTEHTSVVMSlICW---DQFLLSCSLDNTVKIWAAtEGGNLEVTYTHkEEYGVLALCGVH 365
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRS-VAFspdGRLLASGSADGTVRLWDL-ATGELLRTLTG-HSGGVNSVAFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727526898 366 DAEakpVLLCSCNDNSLHLYDLPSFTERGKILAKQE-IRSIQIGP-GGIFFTGDGSGQVKVWKWST 429
Cdd:COG2319  299 DGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPdGKTLASGSDDGTVRLWDLAT 361
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 114-132 3.53e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


:

Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.17  E-value: 3.53e-06
                          10
                  ....*....|....*....
gi 727526898  114 CKFWVDGNCPYGDKCRYLH 132
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-429 2.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVLN-LCGEVGCM-IS-EGPWLLVG-MPNLVK 213
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVaFSpDGKTLASGsADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 214 AWNIQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTscfdPAASLKGHTLAVVSLYVGAN--RLYS 288
Cdd:COG2319  146 LWDLATGKLLrTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 289 GAMDNVIKVWSLDNLQCIQTLTEHTSVVMSlICW---DQFLLSCSLDNTVKIWAAtEGGNLEVTYTHkEEYGVLALCGVH 365
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRS-VAFspdGRLLASGSADGTVRLWDL-ATGELLRTLTG-HSGGVNSVAFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727526898 366 DAEakpVLLCSCNDNSLHLYDLPSFTERGKILAKQE-IRSIQIGP-GGIFFTGDGSGQVKVWKWST 429
Cdd:COG2319  299 DGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPdGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-426 3.75e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 3.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 142 LLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCtgVLNLCGEVGCM-----ISEGPWLL-VGMPNLVKAW 215
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVrdvaaSADGTYLAsGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 216 NIQNNADLS-LTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTSCFdpaaSLKGHTLAVVSL-YVGANR-LYSGA 290
Cdd:cd00200   79 DLETGECVRtLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLT----TLRGHTDWVNSVaFSPDGTfVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 291 MDNVIKVWSLDNLQCIQTLTEHTSVVMSlICWD---QFLLSCSLDNTVKIWAATEGGNLEVTYTHkeEYGVLALCgVHDa 367
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNS-VAFSpdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVA-FSP- 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727526898 368 eaKPVLLCSCN-DNSLHLYDLPSFTERGKILAKQE-IRSIQIGP-GGIFFTGDGSGQVKVWK 426
Cdd:cd00200  230 --DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 242-337 2.44e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 242 LFAGTQDGSILVWKYNS---TTSCFDPAASLKGHT--LAVVSLYVGA-NRLYSGAMDNVIKVWSLDNLQCIQTLTEHTSV 315
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHTkkVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 727526898 316 VMSLIcWD---QFLLSCSLDNTVKI 337
Cdd:PTZ00421 171 ITSLE-WNldgSLLCTTSKDKKLNI 194
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 114-132 3.53e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.17  E-value: 3.53e-06
                          10
                  ....*....|....*....
gi 727526898  114 CKFWVDGNCPYGDKCRYLH 132
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
111-133 8.37e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 42.23  E-value: 8.37e-06
                           10        20
                   ....*....|....*....|...
gi 727526898   111 EKLCKFWVDGNCPYGDKCRYLHC 133
Cdd:smart00356   4 TELCKFFKRGYCPRGDRCKFAHP 26
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-178 6.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.11e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 727526898   139 SFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWD 178
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-178 6.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 727526898  140 FSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWD 178
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-429 2.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVLN-LCGEVGCM-IS-EGPWLLVG-MPNLVK 213
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVaFSpDGKTLASGsADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 214 AWNIQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTscfdPAASLKGHTLAVVSLYVGAN--RLYS 288
Cdd:COG2319  146 LWDLATGKLLrTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPDgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 289 GAMDNVIKVWSLDNLQCIQTLTEHTSVVMSlICW---DQFLLSCSLDNTVKIWAAtEGGNLEVTYTHkEEYGVLALCGVH 365
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRS-VAFspdGRLLASGSADGTVRLWDL-ATGELLRTLTG-HSGGVNSVAFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727526898 366 DAEakpVLLCSCNDNSLHLYDLPSFTERGKILAKQE-IRSIQIGP-GGIFFTGDGSGQVKVWKWST 429
Cdd:COG2319  299 DGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPdGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-426 3.75e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 3.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 142 LLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCtgVLNLCGEVGCM-----ISEGPWLL-VGMPNLVKAW 215
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVrdvaaSADGTYLAsGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 216 NIQNNADLS-LTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTSCFdpaaSLKGHTLAVVSL-YVGANR-LYSGA 290
Cdd:cd00200   79 DLETGECVRtLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLT----TLRGHTDWVNSVaFSPDGTfVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 291 MDNVIKVWSLDNLQCIQTLTEHTSVVMSlICWD---QFLLSCSLDNTVKIWAATEGGNLEVTYTHkeEYGVLALCgVHDa 367
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNS-VAFSpdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVA-FSP- 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727526898 368 eaKPVLLCSCN-DNSLHLYDLPSFTERGKILAKQE-IRSIQIGP-GGIFFTGDGSGQVKVWK 426
Cdd:cd00200  230 --DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNsVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
142-429 7.04e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 7.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 142 LLTQLDGHQKVVTGIAL-PSGSdKLYTASKDETVRIWDCASGQCTGVLNlcGEVGCMIS-----EGPWLLVGMP-NLVKA 214
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFsPDGK-TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSvafspDGKLLASGSDdGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 215 WNIQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTscfdPAASLKGHTLAVVSLYVGAN--RLYSG 289
Cdd:COG2319  189 WDLATGKLLrTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGK----LLRTLTGHSGSVRSVAFSPDgrLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 290 AMDNVIKVWSLDNLQCIQTLTEHTSVVMSlICW---DQFLLSCSLDNTVKIWAATEGgnlEVTYTHK-EEYGVLALCGVH 365
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNS-VAFspdGKLLASGSDDGTVRLWDLATG---KLLRTLTgHTGAVRSVAFSP 340

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727526898 366 DAEakpVLLCSCNDNSLHLYDLPSFTERGKILA-KQEIRSIQIGP-GGIFFTGDGSGQVKVWKWST 429
Cdd:COG2319  341 DGK---TLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
138-338 1.04e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 1.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVLNL-CGEVGCM-IS-EGPWLLVGMP-NLVK 213
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVaFSpDGRLLASGSAdGTVR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 214 AWNIQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTscfdPAASLKGHTLAVVSLYVGAN--RLYS 288
Cdd:COG2319  272 LWDLATGELLrTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPDgkTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727526898 289 GAMDNVIKVWSLDNLQCIQTLTEHTSVVMSlICW---DQFLLSCSLDNTVKIW 338
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTGHTGAVTS-VAFspdGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-338 9.95e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 9.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 141 SLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVLNL-CGEVGCM--ISEGPWLLVGMPNL-VKAWN 216
Cdd:cd00200   42 ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKtIKVWD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 217 IQNNADL-SLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSTTSCfdpaASLKGHTLAVVSLYV--GANRLYSGAM 291
Cdd:cd00200  122 VETGKCLtTLRGHTDWVNSVAFSPDgtFVASSSQDGTIKLWDLRTGKCV----ATLTGHTGEVNSVAFspDGEKLLSSSS 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 727526898 292 DNVIKVWSLDNLQCIQTLTEHTSVVMSLiCWDQ---FLLSCSLDNTVKIW 338
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGHENGVNSV-AFSPdgyLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-339 7.84e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 7.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVlnlcgevgcmisegpwllvgmpnlvkawni 217
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT------------------------------ 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 218 qnnadlsLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKynstTSCFDPAASLKGHTLAVVSLYVGANRLY--SGAMDN 293
Cdd:cd00200  173 -------LTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWD----LSTGKCLGTLRGHENGVNSVAFSPDGYLlaSGSEDG 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 727526898 294 VIKVWSLDNLQCIQTLTEHTSVVMSLiCWD---QFLLSCSLDNTVKIWA 339
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSL-AWSpdgKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-299 4.50e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 4.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 137 GDSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCASGQCTGVlnlcgevgcmisegpwllvgmpnlvkawn 216
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT----------------------------- 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 217 iqnnadlsLTGPVGQVYSLVVGTD--LLFAGTQDGSILVWKYNSttscFDPAASLKGHTLAVVSLYV--GANRLYSGAMD 292
Cdd:cd00200  215 --------LRGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRT----GECVQTLSGHTNSVTSLAWspDGKRLASGSAD 282


                 ....*..
gi 727526898 293 NVIKVWS 299
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
214-433 4.76e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 4.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 214 AWNIQNNADLSLTGPVGQVYSLVVGTDLLFAGTQDGSILVWKYNSTTScfDPAASLKGHTLAVVSLYV--GANRLYSGAM 291
Cdd:COG2319   21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFspDGRLLASASA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 292 DNVIKVWSLDNLQCIQTLTEHTSVVMSlICWD---QFLLSCSLDNTVKIWAATEGGNLEVTYTHKEeyGVLALCGVHDAE 368
Cdd:COG2319   99 DGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSpdgKTLASGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGK 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727526898 369 akpVLLCSCNDNSLHLYDLPSFTERGKILA-KQEIRSIQIGPGG-IFFTGDGSGQVKVWKWSTEPTV 433
Cdd:COG2319  176 ---LLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLL 239
PTZ00421 PTZ00421
coronin; Provisional
 242-337 2.44e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727526898 242 LFAGTQDGSILVWKYNS---TTSCFDPAASLKGHT--LAVVSLYVGA-NRLYSGAMDNVIKVWSLDNLQCIQTLTEHTSV 315
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeglTQNISDPIVHLQGHTkkVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100
                 ....*....|....*....|....*
gi 727526898 316 VMSLIcWD---QFLLSCSLDNTVKI 337
Cdd:PTZ00421 171 ITSLE-WNldgSLLCTTSKDKKLNI 194
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 114-132 3.53e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.17  E-value: 3.53e-06
                          10
                  ....*....|....*....
gi 727526898  114 CKFWVDGNCPYGDKCRYLH 132
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
111-133 8.37e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 42.23  E-value: 8.37e-06
                           10        20
                   ....*....|....*....|...
gi 727526898   111 EKLCKFWVDGNCPYGDKCRYLHC 133
Cdd:smart00356   4 TELCKFFKRGYCPRGDRCKFAHP 26
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-178 6.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.11e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 727526898   139 SFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWD 178
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-178 6.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 727526898  140 FSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWD 178
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-338 7.23e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.23e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 727526898   302 NLQCIQTLTEHTSVVMSlICWD---QFLLSCSLDNTVKIW 338
Cdd:smart00320   1 SGELLKTLKGHTGPVTS-VAFSpdgKYLASGSDDGTIKLW 39
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 112-132 1.34e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 38.72  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|.
gi 727526898  112 KLCKFWVDGNCPYGDKCRYLH 132
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
WD40 pfam00400
WD domain, G-beta repeat;
304-338 1.74e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 727526898  304 QCIQTLTEHTSVVMSLiCWD---QFLLSCSLDNTVKIW 338
Cdd:pfam00400   2 KLLKTLEGHTGSVTSL-AFSpdgKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
138-181 3.83e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.83e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 727526898 138 DSFSLLTQLDGHQKVVTGIALPSGSDKLYTASKDETVRIWDCAS 181
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
109-132 2.09e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.25  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 727526898  109 KTEkLCKFW-VDGNCPYGDKCRYLH 132
Cdd:pfam00642   2 KTE-LCRFFlRTGYCKYGDRCKFAH 25
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
 113-132 4.53e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 34.41  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|
gi 727526898  113 LCKFWvdGNCPYGDKCRYLH 132
Cdd:pfam14608   1 PCRFG--GNCTFGPKCPFSH 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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