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Conserved domains on  [gi|7262426|dbj|BAA90324|]
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dissimilatory sulfite reductase subunit alpha, partial [uncultured sulfate-reducer HMS-66]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dsrA super family cl37041
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-104 1.05e-44

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


The actual alignment was detected with superfamily member TIGR02064:

Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 148.83  E-value: 1.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7262426      1 IGTWKDDIKVDQAKVQEYA--KAGTDVEKELCDMCPSKCISWDG-KTPDIDNGECVKCMHCINVMPKALRPGKEKGATIL 77
Cdd:TIGR02064 220 IGTWKDDIKVDQEAVKAYIagWGKFDIENEVVNRCPTKAISWDGsKELSIDNRECVRCMHCINKMPKALHPGDERGVTIL 299

                          90       100
                  ....*....|....*....|....*..
gi 7262426     78 IGAKAPIIGGALLAAV*VPFL*MEAPF 104
Cdd:TIGR02064 300 IGGKAPILDGAQMGWVVVPFVEAEEPY 326
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-104 1.05e-44

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 148.83  E-value: 1.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7262426      1 IGTWKDDIKVDQAKVQEYA--KAGTDVEKELCDMCPSKCISWDG-KTPDIDNGECVKCMHCINVMPKALRPGKEKGATIL 77
Cdd:TIGR02064 220 IGTWKDDIKVDQEAVKAYIagWGKFDIENEVVNRCPTKAISWDGsKELSIDNRECVRCMHCINKMPKALHPGDERGVTIL 299

                          90       100
                  ....*....|....*....|....*..
gi 7262426     78 IGAKAPIIGGALLAAV*VPFL*MEAPF 104
Cdd:TIGR02064 300 IGGKAPILDGAQMGWVVVPFVEAEEPY 326
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 31-72 5.07e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 48.51  E-value: 5.07e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7262426   31 DMCPSKCISWDGKTPDIDNGECVKCMHCINVMPK-ALRPGKEK 72
Cdd:COG2221  25 AVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTgAIKGEKPK 67
 
Name Accession Description Interval E-value
dsrA TIGR02064
sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes ...
 1-104 1.05e-44

sulfite reductase, dissimilatory-type alpha subunit; Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction. Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster. This model describes the alpha subunit of sulfite reductase. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 273948 [Multi-domain]  Cd Length: 402  Bit Score: 148.83  E-value: 1.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7262426      1 IGTWKDDIKVDQAKVQEYA--KAGTDVEKELCDMCPSKCISWDG-KTPDIDNGECVKCMHCINVMPKALRPGKEKGATIL 77
Cdd:TIGR02064 220 IGTWKDDIKVDQEAVKAYIagWGKFDIENEVVNRCPTKAISWDGsKELSIDNRECVRCMHCINKMPKALHPGDERGVTIL 299

                          90       100
                  ....*....|....*....|....*..
gi 7262426     78 IGAKAPIIGGALLAAV*VPFL*MEAPF 104
Cdd:TIGR02064 300 IGGKAPILDGAQMGWVVVPFVEAEEPY 326
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 31-72 5.07e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 48.51  E-value: 5.07e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 7262426   31 DMCPSKCISWDGKTPDIDNGECVKCMHCINVMPK-ALRPGKEK 72
Cdd:COG2221  25 AVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTgAIKGEKPK 67
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
31-63 2.12e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 33.94  E-value: 2.12e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 7262426   31 DMCPSKCISWDGKTPDIDNGECVKCMHCINVMP 63
Cdd:COG2768  21 KVCPVGAISIEDGKAVIDPEKCIGCGACIEVCP 53
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 31-74 5.11e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 33.09  E-value: 5.11e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 7262426   31 DMCPSKCISWDGKTPDIDNGECVKCMHCINVMP-KALRPGKEKGA 74
Cdd:COG4231  32 KVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPvDAIKLEKRVPE 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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