NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|725878863|gb|AIY42609|]
View 

L-arabinolactonase [Collimonas arenae]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 12093833)

SMP-30/gluconolactonase/LRE family protein similar to vertebrate senescence marker protein 30 (SMP-30) and to Pseudomonas putida 6-deoxy-6-sulfogluconolactonase, which catalyzes the hydrolysis of 6-deoxy-6-sulfo-D-glucono-1,5-lactone to form 6-deoxy-6-sulfo-D-gluconate

EC:  3.1.1.99
Gene Ontology:  GO:0046872|GO:0016787
SCOP:  4003251

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 18-263 2.44e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


:

Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.15  E-value: 2.44e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   18 LGEGVLWCQRTQCLLWTDIIGATLWRHHPATSVTQSWPMPERLATFALTnDDDRLLLGLASQLAWFNFSSNVVTPICAVE 97
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPR-DDGGLIVALKDGVALLDLATGELTPLADPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   98 A-ELPHTRVNDGRCDRAGRFVFGTKN-DAADMAACAGFYRLNQDLTLERLaLPPVAISNSICFSPDGRVMYYCDSLSKKI 175
Cdd:pfam08450  80 DdDWPLNRFNDGKVDPDGRFWFGTMGdDEAPGGDPGALYRLDPDGKLTRV-LDGLTISNGLAWSPDGRTLYFADSPARKI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  176 HCCDYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMVDVPVAQPSCVAFGGDNLD 255
Cdd:pfam08450 159 WAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLR 238


                  ....*...
gi 725878863  256 ILYVTSAR 263
Cdd:pfam08450 239 TLYVTSAR 246
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 18-263 2.44e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.15  E-value: 2.44e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   18 LGEGVLWCQRTQCLLWTDIIGATLWRHHPATSVTQSWPMPERLATFALTnDDDRLLLGLASQLAWFNFSSNVVTPICAVE 97
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPR-DDGGLIVALKDGVALLDLATGELTPLADPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   98 A-ELPHTRVNDGRCDRAGRFVFGTKN-DAADMAACAGFYRLNQDLTLERLaLPPVAISNSICFSPDGRVMYYCDSLSKKI 175
Cdd:pfam08450  80 DdDWPLNRFNDGKVDPDGRFWFGTMGdDEAPGGDPGALYRLDPDGKLTRV-LDGLTISNGLAWSPDGRTLYFADSPARKI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  176 HCCDYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMVDVPVAQPSCVAFGGDNLD 255
Cdd:pfam08450 159 WAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLR 238


                  ....*...
gi 725878863  256 ILYVTSAR 263
Cdd:pfam08450 239 TLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 10-291 3.47e-84

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 254.05  E-value: 3.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  10 LVFDGKHQLGEGVLWCQRtQCLLWTDIIGATLWRHHPATSVTQSWPMPERLATFALTNDDDRLLLG-LASQLAWFNFSSN 88
Cdd:COG3386    1 KLADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVAdHGRGLVRFDPADG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  89 VVTPICAvEAELPHTRVNDGRCDRAGRFVFGtknDAADMAACAGFYRLNQDLTLERLAlPPVAISNSICFSPDGRVMYYC 168
Cdd:COG3386   80 EVTVLAD-EYGKPLNRPNDGVVDPDGRLYFT---DMGEYLPTGALYRVDPDGSLRVLA-DGLTFPNGIAFSPDGRTLYVA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 169 DSLSKKIHCCDYDsAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMVDVPVAQPSCVA 248
Cdd:COG3386  155 DTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTNVA 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 725878863 249 FGGDNLDILYVTSAREsmsaaallaEPAAGGVFRHQLaDVRGL 291
Cdd:COG3386  234 FGGPDLRTLYVTTARS---------LPLAGALFRVRV-DVPGL 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 156-260 1.42e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 156 ICFSPDGRVmYYCDSLSKKIHCcdYDSAAGAVskpRLFADLSAQPG---EPDGSAIDSDGYLWNAQWGGHRVVRFAPDGS 232
Cdd:cd05819  107 IAVDSSGNI-YVADTGNHRIQK--FDPDGEFL---TTFGSGGSGPGqfnGPTGVAVDSDGNIYVADTGNHRIQVFDPDGN 180

                         90       100       110
                 ....*....|....*....|....*....|....
gi 725878863 233 I------ERMVDVPVAQPSCVAFGGDNLdiLYVT 260
Cdd:cd05819  181 FlttfgsTGTGPGQFNYPTGIAVDSDGN--IYVA 212
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 18-263 2.44e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.15  E-value: 2.44e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   18 LGEGVLWCQRTQCLLWTDIIGATLWRHHPATSVTQSWPMPERLATFALTnDDDRLLLGLASQLAWFNFSSNVVTPICAVE 97
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPR-DDGGLIVALKDGVALLDLATGELTPLADPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863   98 A-ELPHTRVNDGRCDRAGRFVFGTKN-DAADMAACAGFYRLNQDLTLERLaLPPVAISNSICFSPDGRVMYYCDSLSKKI 175
Cdd:pfam08450  80 DdDWPLNRFNDGKVDPDGRFWFGTMGdDEAPGGDPGALYRLDPDGKLTRV-LDGLTISNGLAWSPDGRTLYFADSPARKI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  176 HCCDYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMVDVPVAQPSCVAFGGDNLD 255
Cdd:pfam08450 159 WAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLR 238


                  ....*...
gi 725878863  256 ILYVTSAR 263
Cdd:pfam08450 239 TLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 10-291 3.47e-84

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 254.05  E-value: 3.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  10 LVFDGKHQLGEGVLWCQRtQCLLWTDIIGATLWRHHPATSVTQSWPMPERLATFALTNDDDRLLLG-LASQLAWFNFSSN 88
Cdd:COG3386    1 KLADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVAdHGRGLVRFDPADG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  89 VVTPICAvEAELPHTRVNDGRCDRAGRFVFGtknDAADMAACAGFYRLNQDLTLERLAlPPVAISNSICFSPDGRVMYYC 168
Cdd:COG3386   80 EVTVLAD-EYGKPLNRPNDGVVDPDGRLYFT---DMGEYLPTGALYRVDPDGSLRVLA-DGLTFPNGIAFSPDGRTLYVA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 169 DSLSKKIHCCDYDsAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMVDVPVAQPSCVA 248
Cdd:COG3386  155 DTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTNVA 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 725878863 249 FGGDNLDILYVTSAREsmsaaallaEPAAGGVFRHQLaDVRGL 291
Cdd:COG3386  234 FGGPDLRTLYVTTARS---------LPLAGALFRVRV-DVPGL 266
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
32-240 1.42e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.64  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863  32 LW-TDIIGATLWRHHPATSVTQSWPMPERLAT-FALTNDDDRLL---LGLASQLAWFNFSSNVVTpicAVEAELPHTRVN 106
Cdd:COG4257   72 LWfTDNGNNRIGRIDPKTGEITTFALPGGGSNpHGIAFDPDGNLwftDQGGNRIGRLDPATGEVT---EFPLPTGGAGPY 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 107 DGRCDRAGRFVFgtkndaADMAAcAGFYRLN-QDLTLERLALP-PVAISNSICFSPDGRVmYYCDSLSKKIHccDYDSAA 184
Cdd:COG4257  149 GIAVDPDGNLWV------TDFGA-NAIGRIDpDTGTLTEYALPtPGAGPRGLAVDPDGNL-WVADTGSGRIG--RFDPKT 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 725878863 185 GAVSKprlFAdLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIeRMVDVP 240
Cdd:COG4257  219 GTVTE---YP-LPGGGARPYGVAVDGDGRVWFAESGANRIVRFDPDTEL-TEYVLP 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
160-263 2.44e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.09  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 160 PDGRVmYYCDSLSKKIHccDYDSAAGAVSKPRLFADlsaqpGEPDGSAIDSDGYLWNAQWGGHRVVRF-APDGSIERmVD 238
Cdd:COG4257   26 PDGAV-WFTDQGGGRIG--RLDPATGEFTEYPLGGG-----SGPHGIAVDPDGNLWFTDNGNNRIGRIdPKTGEITT-FA 96

                         90       100
                 ....*....|....*....|....*..
gi 725878863 239 VP--VAQPSCVAFGGDnlDILYVTSAR 263
Cdd:COG4257   97 LPggGSNPHGIAFDPD--GNLWFTDQG 121
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 156-260 1.42e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 156 ICFSPDGRVmYYCDSLSKKIHCcdYDSAAGAVskpRLFADLSAQPG---EPDGSAIDSDGYLWNAQWGGHRVVRFAPDGS 232
Cdd:cd05819  107 IAVDSSGNI-YVADTGNHRIQK--FDPDGEFL---TTFGSGGSGPGqfnGPTGVAVDSDGNIYVADTGNHRIQVFDPDGN 180

                         90       100       110
                 ....*....|....*....|....*....|....
gi 725878863 233 I------ERMVDVPVAQPSCVAFGGDNLdiLYVT 260
Cdd:cd05819  181 FlttfgsTGTGPGQFNYPTGIAVDSDGN--IYVA 212
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 156-233 2.22e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 156 ICFSPDGRVmYYCDSLSKKIHCCDYDSAAgavskPRLFADLSAQPGE---PDGSAIDSDGYLWNAQWGGHRVVRFAPDGS 232
Cdd:cd14956   65 LAVDKDGWL-YVADYWGDRIQVFTLTGEL-----QTIGGSSGSGPGQfnaPRGVAVDADGNLYVADFGNQRIQKFDPDGS 138


                 .
gi 725878863 233 I 233
Cdd:cd14956  139 F 139
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
156-261 6.90e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.47  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 156 ICFSPDGRVmYYCDSLSKKIHCcdYDSAAGAVSKPRLFADLSAqpgePDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIER 235
Cdd:COG4257   64 IAVDPDGNL-WFTDNGNNRIGR--IDPKTGEITTFALPGGGSN----PHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVT 136

                         90       100
                 ....*....|....*....|....*...
gi 725878863 236 MVDVPV--AQPSCVAFGGDNldILYVTS 261
Cdd:COG4257  137 EFPLPTggAGPYGIAVDPDG--NLWVTD 162
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 155-260 1.05e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 155 SICFSPDGRVmYYCDSLSKKIHCcdYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIE 234
Cdd:cd05819  153 GVAVDSDGNI-YVADTGNHRIQV--FDPDGNFLTTFGSTGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGF 229

                         90       100       110
                 ....*....|....*....|....*....|..
gi 725878863 235 ------RMVDVPVAQPSCVAFGGDNLdiLYVT 260
Cdd:cd05819  230 ggngnfLGSDGQFNRPSGLAVDSDGN--LYVA 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 195-260 6.38e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 6.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 725878863 195 DLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIERMV------DVPVAQPSCVAFGGDNLdiLYVT 260
Cdd:cd05819    2 TGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFgsfgsgDGQFNEPAGVAVDSDGN--LYVA 71
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 155-260 1.01e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 155 SICFSPDGRVmYYCDSLSKKIhcCDYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIE 234
Cdd:cd05819   12 GIAVDSSGNI-YVADTGNNRI--QVFDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGNFL 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 725878863 235 RMV------DVPVAQPSCVAFggDNLDILYVT 260
Cdd:cd05819   89 ASFggsgdgDGEFNGPRGIAV--DSSGNIYVA 118
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 158-260 1.16e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.61  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 725878863 158 FSPDGRVmYYCDSLSKKIHccDYDSAAGAVSKPRLFADLSAQPGEPDGSAIDSDGYLWNAQWGGHRVVRFAPDGSIER-- 235
Cdd:cd05819   62 VDSDGNL-YVADTGNHRIQ--KFDPDGNFLASFGGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFLTtf 138

                         90       100
                 ....*....|....*....|....*....
gi 725878863 236 ----MVDVPVAQPSCVAFGGDNLdiLYVT 260
Cdd:cd05819  139 gsggSGPGQFNGPTGVAVDSDGN--IYVA 165
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
201-260 2.63e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 38.85  E-value: 2.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 725878863 201 GEPDGSAIDSDGYLWNAQWGGHRVVRFAP-DGSIERMVDVPVAQPSCVAFGGDNldILYVT 260
Cdd:COG4257   17 SGPRDVAVDPDGAVWFTDQGGGRIGRLDPaTGEFTEYPLGGGSGPHGIAVDPDG--NLWFT 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH