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Conserved domains on  [gi|72534652|ref|NP_001026850|]
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runt-related transcription factor 3 isoform 1 [Homo sapiens]

Protein Classification

Runt and RunxI domain-containing protein( domain architecture ID 10467269)

Runt and RunxI domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
69-197 2.69e-98

Runt domain;


:

Pssm-ID: 459963  Cd Length: 129  Bit Score: 289.68  E-value: 2.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652    69 MVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 148
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 72534652   149 FNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRH 197
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
330-429 1.23e-46

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


:

Pssm-ID: 430037  Cd Length: 98  Bit Score: 155.88  E-value: 1.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   330 PQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSS-SGGDRSPTRMLASCTSSAAsvaAGNLMNPSLGGQSDGVEADGSH 408
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVGGSStSGGDRSPSRMLASCTNAST---GSNLLNPNLGNQSDSVDADGSH 77
                          90       100
                  ....*....|....*....|.
gi 72534652   409 SNSPTALSTPGRMDEAVWRPY 429
Cdd:pfam08504  78 SNSPTAMGTSGRMDEAVWRPY 98
PHA03247 super family cl33720
large tegument protein UL36; Provisional
191-325 1.35e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   191 PREPRRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLP 270
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72534652   271 T-----LTESRFPDPRMHYPG-AMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYLPPP 325
Cdd:PHA03247 2961 QpwlgaLVPGRVAVPRFRVPQpAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
69-197 2.69e-98

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 289.68  E-value: 2.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652    69 MVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 148
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 72534652   149 FNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRH 197
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
330-429 1.23e-46

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 155.88  E-value: 1.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   330 PQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSS-SGGDRSPTRMLASCTSSAAsvaAGNLMNPSLGGQSDGVEADGSH 408
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVGGSStSGGDRSPSRMLASCTNAST---GSNLLNPNLGNQSDSVDADGSH 77
                          90       100
                  ....*....|....*....|.
gi 72534652   409 SNSPTALSTPGRMDEAVWRPY 429
Cdd:pfam08504  78 SNSPTAMGTSGRMDEAVWRPY 98
PHA03247 PHA03247
large tegument protein UL36; Provisional
191-325 1.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   191 PREPRRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLP 270
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72534652   271 T-----LTESRFPDPRMHYPG-AMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYLPPP 325
Cdd:PHA03247 2961 QpwlgaLVPGRVAVPRFRVPQpAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
 
Name Accession Description Interval E-value
Runt pfam00853
Runt domain;
69-197 2.69e-98

Runt domain;


Pssm-ID: 459963  Cd Length: 129  Bit Score: 289.68  E-value: 2.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652    69 MVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVAR 148
Cdd:pfam00853   1 LVEVLADHPGELVRTGSPNFLCSVLPTHWRSNKSLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAVMKNQVAR 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 72534652   149 FNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRH 197
Cdd:pfam00853  81 FNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRSK 129
RunxI pfam08504
Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription ...
330-429 1.23e-46

Runx inhibition domain; This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2). Its function might be to interact with functional cofactors.


Pssm-ID: 430037  Cd Length: 98  Bit Score: 155.88  E-value: 1.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   330 PQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSS-SGGDRSPTRMLASCTSSAAsvaAGNLMNPSLGGQSDGVEADGSH 408
Cdd:pfam08504   1 PQNQSGPFQTNSPPYHLYYGTSSGSYQFSMVGGSStSGGDRSPSRMLASCTNAST---GSNLLNPNLGNQSDSVDADGSH 77
                          90       100
                  ....*....|....*....|.
gi 72534652   409 SNSPTALSTPGRMDEAVWRPY 429
Cdd:pfam08504  78 SNSPTAMGTSGRMDEAVWRPY 98
PHA03247 PHA03247
large tegument protein UL36; Provisional
191-325 1.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534652   191 PREPRRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLP 270
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72534652   271 T-----LTESRFPDPRMHYPG-AMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYLPPP 325
Cdd:PHA03247 2961 QpwlgaLVPGRVAVPRFRVPQpAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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