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Conserved domains on  [gi|71653346|ref|XP_815312|]
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proteasome regulatory ATPase subunit 2, putative [Trypanosoma cruzi]

Protein Classification

26S proteasome regulatory subunit 4( domain architecture ID 11488438)

26S proteasome regulatory subunit 4 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 2-437 0e+00

26 proteosome regulatory subunit 4-like protein; Provisional


:

Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 789.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346    2 GQQLPTDTKRQQQKWQPPVASDIGKKKKRHGPDTAAKLPKIYPVKACLLKQLRLERCKDYLLLEEELLKTIGAQREAQEN 81
Cdd:PTZ00361  10 NQKDKNKKKEKKKKESPPPPHEIKRKKKRKGPDAASKLPKVTPNTKCRLRLLKLERIKDYLLLEEEFITNQEAQKPAQEK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   82 LEEgamshyeaELSRVDALRGMPLEVGTLEEVIDDTHAIVSTA-GSEYYVPMLSFVDKEKLELGCSVLLHDRQHSVVGVL 160
Cdd:PTZ00361  90 NEA--------ELKKVDDLRGSPLSVGTLEEIIDENHAIVSSSvGPEYYVNILSFVDKEQLEPGCSVLLHNKTHSVVGIL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  161 QNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQT 240
Cdd:PTZ00361 162 LDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANET 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  241 SATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSN 320
Cdd:PTZ00361 242 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQLDGFDSRG 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  321 DVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAG 400
Cdd:PTZ00361 322 DVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAG 401

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 71653346  401 LLALRDRRMKVCQADFVKGKENVQYRKDKSSFSKFYL 437
Cdd:PTZ00361 402 LLALRERRMKVTQADFRKAKEKVLYRKKGNIPEGLYL 438
 
Name Accession Description Interval E-value
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 2-437 0e+00

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 789.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346    2 GQQLPTDTKRQQQKWQPPVASDIGKKKKRHGPDTAAKLPKIYPVKACLLKQLRLERCKDYLLLEEELLKTIGAQREAQEN 81
Cdd:PTZ00361  10 NQKDKNKKKEKKKKESPPPPHEIKRKKKRKGPDAASKLPKVTPNTKCRLRLLKLERIKDYLLLEEEFITNQEAQKPAQEK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   82 LEEgamshyeaELSRVDALRGMPLEVGTLEEVIDDTHAIVSTA-GSEYYVPMLSFVDKEKLELGCSVLLHDRQHSVVGVL 160
Cdd:PTZ00361  90 NEA--------ELKKVDDLRGSPLSVGTLEEIIDENHAIVSSSvGPEYYVNILSFVDKEQLEPGCSVLLHNKTHSVVGIL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  161 QNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQT 240
Cdd:PTZ00361 162 LDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANET 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  241 SATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSN 320
Cdd:PTZ00361 242 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQLDGFDSRG 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  321 DVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAG 400
Cdd:PTZ00361 322 DVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAG 401

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 71653346  401 LLALRDRRMKVCQADFVKGKENVQYRKDKSSFSKFYL 437
Cdd:PTZ00361 402 LLALRERRMKVTQADFRKAKEKVLYRKKGNIPEGLYL 438
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 161-430 1.22e-129

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 377.04  E-value: 1.22e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 161 QNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQT 240
Cdd:COG1222  57 QKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGEL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 241 SATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGakEVQRTMLELLTQLDGFDSSN 320
Cdd:COG1222 137 GAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSG--EVQRTVNQLLAELDGFESRG 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 321 DVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAG 400
Cdd:COG1222 215 DVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAG 294

                       250       260       270
                ....*....|....*....|....*....|
gi 71653346 401 LLALRDRRMKVCQADFVKGKENVQYRKDKS 430
Cdd:COG1222 295 MFAIREGRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 180-350 1.63e-111

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 325.06  E-value: 1.63e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 180 TYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGD 259
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 260 GPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALI 339
Cdd:cd19502  81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160

                       170
                ....*....|.
gi 71653346 340 RPGRIDRKIEF 350
Cdd:cd19502 161 RPGRFDRKIEF 171
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 174-431 2.73e-78

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 251.05  E-value: 2.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   174 EKAPQETYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELI 253
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   254 QKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIET 333
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFGTNTGVIVIAATNRPDV 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   334 LDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRDRRMKVCQ 413
Cdd:TIGR01241 206 LDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKNKTEITM 285

                         250
                  ....*....|....*...
gi 71653346   414 ADFVKGKENVQYRKDKSS 431
Cdd:TIGR01241 286 NDIEEAIDRVIAGPEKKS 303
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 219-351 3.15e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.62  E-value: 3.15e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   219 VILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydtDSSG 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSR---GSGG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 71653346   299 AKEVQRTMLELLTQLDGFDSSND-VKVIMATNRIETLDPALIrpGRIDRKIEFP 351
Cdd:pfam00004  78 DSESRRVVNQLLTELDGFTSSNSkVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 215-354 4.48e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 83.58  E-value: 4.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346    215 PPKGVILYGVPGTGKTLLAKAVANQTSATFLRVV-----------------GSELIQKYSGDGPKLVRELFRVAEENSPS 277
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346    278 IVFIDEIDAIGTKRYdtdssgakEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPgRIDRKIEFPFPD 354
Cdd:smart00382  81 VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 2-437 0e+00

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 789.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346    2 GQQLPTDTKRQQQKWQPPVASDIGKKKKRHGPDTAAKLPKIYPVKACLLKQLRLERCKDYLLLEEELLKTIGAQREAQEN 81
Cdd:PTZ00361  10 NQKDKNKKKEKKKKESPPPPHEIKRKKKRKGPDAASKLPKVTPNTKCRLRLLKLERIKDYLLLEEEFITNQEAQKPAQEK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   82 LEEgamshyeaELSRVDALRGMPLEVGTLEEVIDDTHAIVSTA-GSEYYVPMLSFVDKEKLELGCSVLLHDRQHSVVGVL 160
Cdd:PTZ00361  90 NEA--------ELKKVDDLRGSPLSVGTLEEIIDENHAIVSSSvGPEYYVNILSFVDKEQLEPGCSVLLHNKTHSVVGIL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  161 QNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQT 240
Cdd:PTZ00361 162 LDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANET 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  241 SATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSN 320
Cdd:PTZ00361 242 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQLDGFDSRG 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  321 DVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAG 400
Cdd:PTZ00361 322 DVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAG 401

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 71653346  401 LLALRDRRMKVCQADFVKGKENVQYRKDKSSFSKFYL 437
Cdd:PTZ00361 402 LLALRERRMKVTQADFRKAKEKVLYRKKGNIPEGLYL 438
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 90-434 2.01e-167

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 475.48  E-value: 2.01e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   90 YEAELSR----VDALRGMPLEVGTLEEVIDDTHAIV-STAGSEYYVPMLSFVDKEKLELGCSVLLHDRQHSVVGVLQNSI 164
Cdd:PRK03992  34 LERELERlkseLEKLKSPPLIVATVLEVLDDGRVVVkSSGGPQFLVNVSPFIDREKLKPGARVALNQQSLAIVEVLPSEK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  165 DPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATF 244
Cdd:PRK03992 114 DPRVQAMEVIESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATF 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  245 LRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKV 324
Cdd:PRK03992 194 IRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDREVQRTLMQLLAEMDGFDPRGNVKI 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  325 IMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLAL 404
Cdd:PRK03992 274 IAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAI 353

                        330       340       350
                 ....*....|....*....|....*....|
gi 71653346  405 RDRRMKVCQADFVKGKENVQYRKDKSSFSK 434
Cdd:PRK03992 354 RDDRTEVTMEDFLKAIEKVMGKEEKDSMEE 383
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 76-429 1.54e-153

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 440.74  E-value: 1.54e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   76 REAQENLEEgAMSHYEAELSRVDALrgmPLEVGTLEEVIDDTHAIV-STAGSEYYVPMLSFVDKEKLELGCSVLLHDRQH 154
Cdd:PTZ00454  42 KEEQKNLKR-ELIRAKEEVKRIQSV---PLVIGQFLEMIDSNYGIVsSTSGSNYYVRILSTLNRELLKPNASVALHRHSH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  155 SVVGVLQNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAK 234
Cdd:PTZ00454 118 AVVDILPPEADSSIQLLQMSEKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  235 AVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLD 314
Cdd:PTZ00454 198 AVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMD 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  315 GFDSSNDVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKA 394
Cdd:PTZ00454 278 GFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAA 357

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 71653346  395 ICTEAGLLALRDRRMKVCQADFVKGKENVQYRKDK 429
Cdd:PTZ00454 358 ICQEAGMQAVRKNRYVILPKDFEKGYKTVVRKTDR 392
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 161-430 1.22e-129

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 377.04  E-value: 1.22e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 161 QNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQT 240
Cdd:COG1222  57 QKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGEL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 241 SATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGakEVQRTMLELLTQLDGFDSSN 320
Cdd:COG1222 137 GAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSG--EVQRTVNQLLAELDGFESRG 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 321 DVKVIMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAG 400
Cdd:COG1222 215 DVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAG 294

                       250       260       270
                ....*....|....*....|....*....|
gi 71653346 401 LLALRDRRMKVCQADFVKGKENVQYRKDKS 430
Cdd:COG1222 295 MFAIREGRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 180-350 1.63e-111

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 325.06  E-value: 1.63e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 180 TYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGD 259
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 260 GPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALI 339
Cdd:cd19502  81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160

                       170
                ....*....|.
gi 71653346 340 RPGRIDRKIEF 350
Cdd:cd19502 161 RPGRFDRKIEF 171
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 75-426 8.97e-81

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.84  E-value: 8.97e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  75 QREAQENLEEGAMSHYEAELSRVDALRGMPLEVGTLEEVIDDTHAIVSTAGSEYYVPMLSFVDKEKLELGCSVLLHDRQH 154
Cdd:COG0464  50 ALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEAL 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 155 SVVGVLQNSIDPHVSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAK 234
Cdd:COG0464 130 ALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLAR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 235 AVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTmleLLTQLD 314
Cdd:COG0464 210 ALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNT---LLTEME 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 315 GFDSsnDVKVIMATNRIETLDPALIRpgRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKA 394
Cdd:COG0464 287 ELRS--DVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRN 362

                       330       340       350
                ....*....|....*....|....*....|..
gi 71653346 395 ICTEAGLLALRDRRMKVCQADFVKGKENVQYR 426
Cdd:COG0464 363 VVRRAALQALRLGREPVTTEDLLEALEREDIF 394
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 174-431 2.73e-78

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 251.05  E-value: 2.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   174 EKAPQETYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELI 253
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   254 QKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIET 333
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFGTNTGVIVIAATNRPDV 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   334 LDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRDRRMKVCQ 413
Cdd:TIGR01241 206 LDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKNKTEITM 285

                         250
                  ....*....|....*...
gi 71653346   414 ADFVKGKENVQYRKDKSS 431
Cdd:TIGR01241 286 NDIEEAIDRVIAGPEKKS 303
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 177-406 2.00e-77

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 254.83  E-value: 2.00e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   177 PQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKY 256
Cdd:TIGR01243 448 PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKW 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   257 SGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDP 336
Cdd:TIGR01243 528 VGESEKAIREIFRKARQAAPAIIFFDEIDAIAPAR--GARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDP 605

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   337 ALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRD 406
Cdd:TIGR01243 606 ALLRPGRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRE 675
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 168-405 2.82e-74

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 246.74  E-value: 2.82e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   168 VSIMKVEKAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRV 247
Cdd:TIGR01243 164 VREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISI 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   248 VGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydTDSSGAKEvQRTMLELLTQLDGFDSSNDVKVIMA 327
Cdd:TIGR01243 244 NGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKR--EEVTGEVE-KRVVAQLLTLMDGLKGRGRVIVIGA 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71653346   328 TNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALR 405
Cdd:TIGR01243 321 TNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALR 398
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 183-350 5.74e-69

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 216.00  E-value: 5.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPK 262
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 263 LVRELFRVAEENSPSIVFIDEIDAIGTKRyDTDSSGAKevQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPG 342
Cdd:cd19503  81 NLREIFEEARSHAPSIIFIDEIDALAPKR-EEDQREVE--RRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPG 157


                ....*...
gi 71653346 343 RIDRKIEF 350
Cdd:cd19503 158 RFDREVEI 165
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 180-348 1.10e-68

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 215.56  E-value: 1.10e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 180 TYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGD 259
Cdd:cd19501   2 TFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 260 GPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALI 339
Cdd:cd19501  81 GASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPALL 160


                ....*....
gi 71653346 340 RPGRIDRKI 348
Cdd:cd19501 161 RPGRFDRQV 169
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
171-424 1.86e-68

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 227.61  E-value: 1.86e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 171 MKVEKAPQETYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGS 250
Cdd:COG0465 131 LYDEDKPKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGS 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 251 ELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydtdssGAK------EVQRTMLELLTQLDGFDSSNDVKV 324
Cdd:COG0465 210 DFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQR------GAGlggghdEREQTLNQLLVEMDGFEGNEGVIV 283

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 325 IMATNRIETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDIsEFIhAKEE--MSGADIKAICTEAGLL 402
Cdd:COG0465 284 IAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDL-EVI-ARRTpgFSGADLANLVNEAALL 361

                       250       260
                ....*....|....*....|..
gi 71653346 403 ALRDRRMKVCQADFVKGKENVQ 424
Cdd:COG0465 362 AARRNKKAVTMEDFEEAIDRVI 383
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 183-351 8.94e-66

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 208.06  E-value: 8.94e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPK 262
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 263 LVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSsgakEVQRTML-ELLTQLDGFDSSNDVKVIMATNRIETLDPALIRP 341
Cdd:cd19519  81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHG----EVERRIVsQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF 156

                       170
                ....*....|
gi 71653346 342 GRIDRKIEFP 351
Cdd:cd19519 157 GRFDREIDIG 166
ftsH CHL00176
cell division protein; Validated
 180-411 3.28e-64

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 217.61  E-value: 3.28e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  180 TYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGD 259
Cdd:CHL00176 181 TFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGV 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  260 GPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALI 339
Cdd:CHL00176 260 GAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALL 339

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71653346  340 RPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRDRRMKV 411
Cdd:CHL00176 340 RPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAAILTARRKKATI 411
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 192-348 2.51e-62

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 198.66  E-value: 2.51e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 192 QEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVA 271
Cdd:cd19511   3 RELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346 272 EENSPSIVFIDEIDAIGTKRYDTDSSGAKEvqRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKI 348
Cdd:cd19511  83 RQAAPCIIFFDEIDSLAPRRGQSDSSGVTD--RVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 192-348 9.25e-61

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 194.64  E-value: 9.25e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 192 QEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVA 271
Cdd:cd19529   3 QELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKA 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346 272 EENSPSIVFIDEIDAIGTKRYDTDSSGAKEvqRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKI 348
Cdd:cd19529  83 RQVAPCVIFFDEIDSIAPRRGTTGDSGVTE--RVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLI 157
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
171-431 4.58e-60

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 206.81  E-value: 4.58e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  171 MKVEKAPQETYADIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGS 250
Cdd:PRK10733 141 MLTEDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGS 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  251 ELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNR 330
Cdd:PRK10733 220 DFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNR 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  331 IETLDPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRDRRMK 410
Cdd:PRK10733 300 PDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRV 379

                        250       260
                 ....*....|....*....|.
gi 71653346  411 VCQADFVKGKENVQYRKDKSS 431
Cdd:PRK10733 380 VSMVEFEKAKDKIMMGAERRS 400
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 190-350 3.77e-59

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 190.57  E-value: 3.77e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 190 QIQEIKEAVEFPLSHPELyDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFR 269
Cdd:cd19481   1 LKASLREAVEAPRRGSRL-RRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 270 VAEENSPSIVFIDEIDAIGTKRydTDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKIE 349
Cdd:cd19481  80 RARRLAPCILFIDEIDAIGRKR--DSSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIE 157


                .
gi 71653346 350 F 350
Cdd:cd19481 158 F 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 219-351 3.15e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.62  E-value: 3.15e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   219 VILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydtDSSG 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSR---GSGG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 71653346   299 AKEVQRTMLELLTQLDGFDSSND-VKVIMATNRIETLDPALIrpGRIDRKIEFP 351
Cdd:pfam00004  78 DSESRRVVNQLLTELDGFTSSNSkVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 192-348 1.54e-50

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 168.46  E-value: 1.54e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 192 QEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVA 271
Cdd:cd19528   3 RELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKA 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71653346 272 EENSPSIVFIDEIDAIGTKRYDT--DSSGAKEvqRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKI 348
Cdd:cd19528  83 RAAAPCVLFFDELDSIAKARGGNigDAGGAAD--RVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLI 159
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 183-348 3.01e-49

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 165.27  E-value: 3.01e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPK 262
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 263 LVRELFRVAEENSPSIVFIDEIDAIGTKRydtdSSGAKEVQRTML-ELLTQLDGF----DSSNDVKVIMATNRIETLDPA 337
Cdd:cd19518  81 KIRELFDQAISNAPCIVFIDEIDAITPKR----ESAQREMERRIVsQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPA 156

                       170
                ....*....|.
gi 71653346 338 LIRPGRIDRKI 348
Cdd:cd19518 157 LRRAGRFDREI 167
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 184-348 5.68e-48

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 161.75  E-value: 5.68e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 184 IGGLEEQIQEIKEAVEFPLSHPELYdEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKL 263
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 264 VRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVqRTmlELLTQLDGF--DSSNDVKVIMATNRIETLDPALIRp 341
Cdd:cd19509  80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRV-KT--EFLVQMDGVlnKPEDRVLVLGATNRPWELDEAFLR- 155


                ....*..
gi 71653346 342 gRIDRKI 348
Cdd:cd19509 156 -RFEKRI 161
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
183-399 8.90e-48

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 163.90  E-value: 8.90e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFpLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPK 262
Cdd:COG1223   3 DVVGQEEAKKKLKLIIKE-LRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETAR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 263 LVRELFRVAEENsPSIVFIDEIDAIGTKRYDTDSSGakEVQRTMLELLTQLDGFDSsnDVKVIMATNRIETLDPALIRpg 342
Cdd:COG1223  82 NLRKLFDFARRA-PCVIFFDEFDAIAKDRGDQNDVG--EVKRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR-- 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346 343 RIDRKIEFPFPDEKTKKMIFEIHTSRMSLAEDVDISEFIHAKEEMSGADIKAICTEA 399
Cdd:COG1223 155 RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTA 211
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 187-346 3.30e-45

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 154.57  E-value: 3.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 187 LEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRE 266
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 267 LFRVAEENSPSIVFIDEIDAIGTKRydtDSSGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDR 346
Cdd:cd19530  81 VFQRARASAPCVIFFDEVDALVPKR---GDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDK 157
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 183-350 4.77e-45

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 154.20  E-value: 4.77e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSA-----TFLRVVGSELIQKYS 257
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 258 GDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRydtdSSGAKEVQRTMLE-LLTQLDGFDSSNDVKVIMATNRIETLDP 336
Cdd:cd19517  81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVR----SSKQEQIHASIVStLLALMDGLDNRGQVVVIGATNRPDALDP 156

                       170
                ....*....|....
gi 71653346 337 ALIRPGRIDRKIEF 350
Cdd:cd19517 157 ALRRPGRFDREFYF 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 183-340 2.39e-43

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 149.50  E-value: 2.39e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVGI-KPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGP 261
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 262 KLVRELFRVAEENSPSIVFIDEIDAIGTKRydtdSSGAKEVQRTM-LELLTQLDGFDSSNDVKVIM--ATNRIETLDPAL 338
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR----SSTDHEATAMMkAEFMSLWDGLSTDGNCRVIVmgATNRPQDLDEAI 156


                ..
gi 71653346 339 IR 340
Cdd:cd19520 157 LR 158
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 193-346 9.03e-42

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 145.35  E-value: 9.03e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 193 EIKEAVEFPLSHPELYDEvGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAE 272
Cdd:cd19527   4 EILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKAR 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71653346 273 ENSPSIVFIDEIDAIGTKRYDTDSSGAKeVQRTMLELLTQLDGF-DSSNDVKVIMATNRIETLDPALIRPGRIDR 346
Cdd:cd19527  83 DAKPCVIFFDELDSLAPSRGNSGDSGGV-MDRVVSQLLAELDGMsSSGQDVFVIGATNRPDLLDPALLRPGRFDK 156
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 194-349 1.57e-41

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 144.49  E-value: 1.57e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 194 IKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVRELFRVAEE 273
Cdd:cd19526   5 LEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQS 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346 274 NSPSIVFIDEIDAIGTKRyDTDSSGAKEvqRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKIE 349
Cdd:cd19526  85 AKPCILFFDEFDSIAPKR-GHDSTGVTD--RVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 177-348 2.15e-40

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 141.92  E-value: 2.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 177 PQETYADIGGLEEQIQEIKEAVEFPLSHPELYDEvGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKY 256
Cdd:cd19521   2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTG-NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 257 SGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKevqRTMLELLTQLDGFDSSND-VKVIMATNRIETLD 335
Cdd:cd19521  81 MGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASR---RIKTELLVQMNGVGNDSQgVLVLGATNIPWQLD 157

                       170
                ....*....|...
gi 71653346 336 PALIRpgRIDRKI 348
Cdd:cd19521 158 SAIRR--RFEKRI 168
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 170-340 1.96e-39

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 140.12  E-value: 1.96e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 170 IMKVekAPQETYADIGGLEEQIQEIKEAVEFPLSHPELYdeVGIK-PPKGVILYGVPGTGKTLLAKAVANQTSATFLRVV 248
Cdd:cd19525  12 IMDH--GPPINWADIAGLEFAKKTIKEIVVWPMLRPDIF--TGLRgPPKGILLFGPPGTGKTLIGKCIASQSGATFFSIS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 249 GSELIQKYSGDGPKLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKevqRTMLELLTQLDGFDSSNDVKVIM-- 326
Cdd:cd19525  88 ASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSR---RIKTEFLVQLDGATTSSEDRILVvg 164

                       170
                ....*....|....
gi 71653346 327 ATNRIETLDPALIR 340
Cdd:cd19525 165 ATNRPQEIDEAARR 178
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 183-340 2.37e-38

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 136.52  E-value: 2.37e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYdeVGIK-PPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGP 261
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELF--TGLRaPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 262 KLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKevqRTMLELLTQLDGFDSSND--VKVIMATNRIETLDPALI 339
Cdd:cd19524  79 KLVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASR---RLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVL 155


                .
gi 71653346 340 R 340
Cdd:cd19524 156 R 156
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 183-348 4.09e-37

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 133.57  E-value: 4.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDevGIKPP-KGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGP 261
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 262 KLVRELFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKevQRTMLELLTQLDGF-------DSSNDVKVIMATNRIETL 334
Cdd:cd19522  79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEAS--RRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDI 156

                       170
                ....*....|....
gi 71653346 335 DPALIRpgRIDRKI 348
Cdd:cd19522 157 DEALRR--RLEKRI 168
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 184-349 2.97e-30

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 115.28  E-value: 2.97e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 184 IGGLEEQIQEI-KEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVV-GSELIQKYSGDGP 261
Cdd:cd19504   2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVnGPEILNKYVGESE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 262 KLVRELFRVAEE--------NSPSIVFIDEIDAIGTKRYDT-DSSGakeVQRTML-ELLTQLDGFDSSNDVKVIMATNRI 331
Cdd:cd19504  82 ANIRKLFADAEEeqrrlganSGLHIIIFDEIDAICKQRGSMaGSTG---VHDTVVnQLLSKIDGVEQLNNILVIGMTNRK 158

                       170
                ....*....|....*...
gi 71653346 332 ETLDPALIRPGRIDRKIE 349
Cdd:cd19504 159 DLIDEALLRPGRLEVQME 176
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 183-340 3.01e-29

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 111.90  E-value: 3.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEQIQEIKEAVEFPLSHPELYDEVgIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPK 262
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 263 LVRELFRVAEENSPSIVFIDEIDAIGTKRYDtdssGAKEVQRTMLELLTQLDGFDSS--NDVKVIMATNRIETLDPALIR 340
Cdd:cd19523  80 ILQASFLAARCRQPSVLFISDLDALLSSQDD----EASPVGRLQVELLAQLDGVLGSgeDGVLVVCTTSKPEEIDESLRR 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 185-351 7.79e-26

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 102.22  E-value: 7.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 185 GGLEEQIQEIKEAVEFPlshpelydevgikPPKGVILYGVPGTGKTLLAKAVANQT---SATFLRVVGSELIQKYSG--- 258
Cdd:cd00009   1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVael 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 259 DGPKLVRELFRVAEENSPSIVFIDEIDAIGtkrydtdssgaKEVQRTMLELL-TQLDGFDSSNDVKVIMATNRIETLDPA 337
Cdd:cd00009  68 FGHFLVRLLFELAEKAKPGVLFIDEIDSLS-----------RGAQNALLRVLeTLNDLRIDRENVRVIGATNRPLLGDLD 136

                       170
                ....*....|....
gi 71653346 338 LIRPGRIDRKIEFP 351
Cdd:cd00009 137 RALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 183-346 1.56e-24

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 98.98  E-value: 1.56e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 183 DIGGLEEqiqeIKEAVEF--PLSHPElYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDG 260
Cdd:cd19507   1 DVGGLDN----LKDWLKKrkAAFSKQ-ASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGES 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 261 PKLVRELFRVAEENSPSIVFIDEID-AIGTKRYDTDSSGAKEVQRTMLELLTQldgfdSSNDVKVIMATNRIETLDPALI 339
Cdd:cd19507  76 ESRLRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSSRVLGTFLTWLQE-----KKKPVFVVATANNVQSLPPELL 150


                ....*..
gi 71653346 340 RPGRIDR 346
Cdd:cd19507 151 RKGRFDE 157
ycf46 CHL00195
Ycf46; Provisional
 176-408 3.43e-24

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 104.72  E-value: 3.43e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  176 APQETYADIGGLEEQIQEIKEAVEfplSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQK 255
Cdd:CHL00195 222 SVNEKISDIGGLDNLKDWLKKRST---SFSKQASNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGG 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  256 YSGDGPKLVRELFRVAEENSPSIVFIDEID-AIGTKRYDTDSSGAKEVQRTMLELLTQldgfdSSNDVKVIMATNRIETL 334
Cdd:CHL00195 299 IVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWLSE-----KKSPVFVVATANNIDLL 373

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346  335 DPALIRPGRIDRKIEFPFPDEKTKKMIFEIHTS--RMSLAEDVDISEFIHAKEEMSGADIKAICTEAGLLALRDRR 408
Cdd:CHL00195 374 PLEILRKGRFDEIFFLDLPSLEEREKIFKIHLQkfRPKSWKKYDIKKLSKLSNKFSGAEIEQSIIEAMYIAFYEKR 449
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 194-350 5.90e-23

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 94.34  E-value: 5.90e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 194 IKEAVEFPLSHPELYDEVGIKPPKGVILYGVPGTGKTLLAKAVANqtsatFLR--VVGSELIQKYSGDgpKLVRELFRVA 271
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAG-----ELDydICDLNLSEVVLTD--DRLNHLLNTA 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 272 EENSpsIVFIDEIDAIGTKRYDTDSSGAK---EVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPGRIDRKI 348
Cdd:cd19510  74 PKQS--IILLEDIDAAFESREHNKKNPSAyggLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKI 151


                ..
gi 71653346 349 EF 350
Cdd:cd19510 152 YM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 215-354 4.48e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 83.58  E-value: 4.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346    215 PPKGVILYGVPGTGKTLLAKAVANQTSATFLRVV-----------------GSELIQKYSGDGPKLVRELFRVAEENSPS 277
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346    278 IVFIDEIDAIGTKRYdtdssgakEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALIRPgRIDRKIEFPFPD 354
Cdd:smart00382  81 VLILDEITSLLDAEQ--------EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 187-350 3.29e-13

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 66.78  E-value: 3.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 187 LEEQIQEIKEAVEFPLSHPELYdevgikppKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSElIQKYSGDGPKLVRE 266
Cdd:cd19512   1 LEARVRDIAIATRNTKKNKGLY--------RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 267 LFRVAEENSPS-IVFIDEIDAIGTKRydtDSSGAKEVQRTMLELLTQLDGfDSSNDVKVIMATNRIETLDPALirPGRID 345
Cdd:cd19512  72 VFDWANTSRRGlLLFVDEADAFLRKR---STEKISEDLRAALNAFLYRTG-EQSNKFMLVLASNQPEQFDWAI--NDRID 145


                ....*
gi 71653346 346 RKIEF 350
Cdd:cd19512 146 EMVEF 150
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 219-339 5.35e-11

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 61.69  E-value: 5.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 219 VILYGVPGTGKTLLAKAVANQTS---------ATFLRVVGSELIQKYSGDGPKLVRELFR-----VAEENSPSIVFIDEI 284
Cdd:cd19508  55 VLLHGPPGTGKTSLCKALAQKLSirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFQkiqelIDDKDALVFVLIDEV 134

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346 285 DAIGTKRYDTDS-SGAKEVQRTMLELLTQLDGFDSSNDVKVIMATNRIETLDPALI 339
Cdd:cd19508 135 ESLAAARSASSSgTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAFV 190
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 374-418 1.57e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 53.31  E-value: 1.57e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 71653346   374 DVDISEFIHAKEEMSGADIKAICTEAGLLALRDRRMKVCQADFVK 418
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLEE 45
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 210-350 5.67e-09

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 55.07  E-value: 5.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 210 EVGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDGPKLVR--------------ELFRVAEENS 275
Cdd:cd19505   6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPDFGNDDWIdgmlilkeslhrlnLQFELAKAMS 85

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71653346 276 PSIVFIDEIDAIGTKRYDTDSsgaKEVQRTMLELLTQLDGFDSSNDVK----VIMATNRIETLDPALIRPGRIDRKIEF 350
Cdd:cd19505  86 PCIIWIPNIHELNVNRSTQNL---EEDPKLLLGLLLNYLSRDFEKSSTrnilVIASTHIPQKVDPALIAPNRLDTCINI 161
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 219-284 4.57e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 55.06  E-value: 4.57e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71653346 219 VILYGVPGTGKTLLAKAVANQTSATFLRV--VGSeliqkysgdGPKLVRELFRVAEENS----PSIVFIDEI 284
Cdd:COG2256  52 MILWGPPGTGKTTLARLIANATDAEFVALsaVTS---------GVKDIREVIEEARERRaygrRTILFVDEI 114
Prot_ATP_ID_OB pfam16450
Proteasomal ATPase OB C-terminal domain; This is the interdomain (ID) or oligonucleotide ...
 107-160 2.03e-07

Proteasomal ATPase OB C-terminal domain; This is the interdomain (ID) or oligonucleotide binding (OB) domain of proteasomal ATPase


Pssm-ID: 465118 [Multi-domain]  Cd Length: 56  Bit Score: 47.50  E-value: 2.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71653346   107 VGTLEEVIDDTHAIV-STAGSEYYVPMLSFVDKEKLELGCSVLLHDRQHSVVGVL 160
Cdd:pfam16450   1 VATVVEVLDDGRALVkSSGGEERVVRLAGSLDEEKLRPGDRVLLDPRSGYALEVL 55
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 219-284 2.42e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 52.78  E-value: 2.42e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  219 VILYGVPGTGKTLLAKAVANQTSATFLRVVGSEliqkysgDGPKLVRELFRVAEENSPS----IVFIDEI 284
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAVT-------SGVKDLREVIEEARQRRSAgrrtILFIDEI 101
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 216-363 5.91e-07

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 49.12  E-value: 5.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   216 PKGVILY-GVPGTGKTLLAKAVANQ---TSATFLRVVGSELIQKYS-----GDGPKLVR-----ELFRVAEENSPSIVFI 281
Cdd:pfam07724   2 PIGSFLFlGPTGVGKTELAKALAELlfgDERALIRIDMSEYMEEHSvsrliGAPPGYVGyeeggQLTEAVRRKPYSIVLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   282 DEIDAIgtkrydtdssgAKEVQRTMLELL--TQL-DGFDSSNDVK---VIMATNR--IETLDPALIRPGRIDRKIEFPFP 353
Cdd:pfam07724  82 DEIEKA-----------HPGVQNDLLQILegGTLtDKQGRTVDFKntlFIMTGNFgsEKISDASRLGDSPDYELLKEEVM 150

                         170
                  ....*....|
gi 71653346   354 DEKTKKMIFE 363
Cdd:pfam07724 151 DLLKKGFIPE 160
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 219-285 6.56e-07

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 50.55  E-value: 6.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 219 VILYGVPGTGKTLLAKAVANQTSATFLRV-----------VGSELIQKYSGD-----GPklvreLFRvaeenspSIVFID 282
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFIRIqftpdllpsdiLGTYIYDQQTGEfefrpGP-----LFA-------NVLLAD 101


                ...
gi 71653346 283 EID 285
Cdd:COG0714 102 EIN 104
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
188-351 3.46e-06

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 49.08  E-value: 3.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 188 EEQIQEIKEAVEfplshPELYDEvgikPPKGVILYGVPGTGKTLLAKAVANQ-----------------------TSATF 244
Cdd:COG1474  32 EEEIEELASALR-----PALRGE----RPSNVLIYGPTGTGKTAVAKYVLEEleeeaeergvdvrvvyvncrqasTRYRV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 245 LRVVGSELIQK-------YSGDgpKLVRELFRVAEENSPSIVFI-DEIDAIGTKRYDTDssgakevqrtmLELLTQLDGF 316
Cdd:COG1474 103 LSRILEELGSGedipstgLSTD--ELFDRLYEALDERDGVLVVVlDEIDYLVDDEGDDL-----------LYQLLRANEE 169

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 71653346 317 DSSNDVKVIMATNRI---ETLDPALIRPGRiDRKIEFP 351
Cdd:COG1474 170 LEGARVGVIGISNDLeflENLDPRVKSSLG-EEEIVFP 206
44 PHA02544
clamp loader, small subunit; Provisional
 220-361 4.51e-06

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 48.45  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  220 ILY-GVPGTGKTLLAKAVANQTSATFLRVVGSEliqkysgDGPKLVR-ELFRVAEENS----PSIVFIDEIDAIGTkryd 293
Cdd:PHA02544  46 LLHsPSPGTGKTTVAKALCNEVGAEVLFVNGSD-------CRIDFVRnRLTRFASTVSltggGKVIIIDEFDRLGL---- 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71653346  294 tdssgaKEVQRTMLELLTQLdgfdsSNDVKVIMATNRIETLDPALIrpGRIdRKIEF--PFPDEKT---KKMI 361
Cdd:PHA02544 115 ------ADAQRHLRSFMEAY-----SKNCSFIITANNKNGIIEPLR--SRC-RVIDFgvPTKEEQIemmKQMI 173
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 205-310 7.36e-06

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 46.22  E-value: 7.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 205 PELYDEVgikPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQ-KYSG-DGPKLVRELFRvaeenspSIVFID 282
Cdd:cd19498  38 EELRDEV---TPKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVGrDVESIIRDLVE-------GIVFID 107

                        90       100       110
                ....*....|....*....|....*....|..
gi 71653346 283 EIDAIGTKrydTDSSGA----KEVQRTMLELL 310
Cdd:cd19498 108 EIDKIAKR---GGSSGPdvsrEGVQRDLLPIV 136
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 218-340 1.32e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.59  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   218 GVILYGVPGTGKTLLAKAVANQTS-ATFLRVVGS------ELIQKYS--GDGPKLV-RELFRVAEEnsPSIVFIDEIDAI 287
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSnRPVFYVQLTrdtteeDLFGRRNidPGGASWVdGPLVRAARE--GEIAVLDEINRA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346   288 GtkrydtdssgaKEVQRTMLELL-----TQLDGF----DSSNDVKVIMATNRIET----LDPALIR 340
Cdd:pfam07728  79 N-----------PDVLNSLLSLLderrlLLPDGGelvkAAPDGFRLIATMNPLDRglneLSPALRS 133
DUF815 pfam05673
Protein of unknown function (DUF815); This family consists of several bacterial proteins of ...
 182-282 1.51e-05

Protein of unknown function (DUF815); This family consists of several bacterial proteins of unknown function.


Pssm-ID: 428578 [Multi-domain]  Cd Length: 250  Bit Score: 46.37  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   182 ADIGGLEEQIQEIKEAVEFPLSHpelydevgiKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVgsELIQKYSGDGP 261
Cdd:pfam05673  28 DDLVGIERQKEALIRNTRRFLAG---------LPANNVLLWGARGTGKSSLVKALLNEYADQGLRLI--EVDKEDLGDLP 96

                          90       100
                  ....*....|....*....|.
gi 71653346   262 KLVRELfrvAEENSPSIVFID 282
Cdd:pfam05673  97 DLVDLL---RDRPYRFILFCD 114
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 217-338 1.80e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 45.24  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 217 KGVIL--YGVPGTGKTLLAKAVANQTSATFLRV-VG-----SELI---QKYSGDGPKLVRELFRVAEENSPSIVfIDEID 285
Cdd:cd19500  36 KGPILclVGPPGVGKTSLGKSIARALGRKFVRIsLGgvrdeAEIRghrRTYVGAMPGRIIQALKKAGTNNPVFL-LDEID 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71653346 286 AIGTKrYDTDSSGAkevqrtMLELL------TQLDG-----FDSSNdVKVIMATNRIETLDPAL 338
Cdd:cd19500 115 KIGSS-FRGDPASA------LLEVLdpeqnsTFSDHyldvpFDLSK-VLFIATANSLDTIPGPL 170
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 112-284 2.72e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 46.30  E-value: 2.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 112 EVIDDTHAIVSTAGSEYYVPMLSFVDKEKLELGcSVLLHDRQHSVVGVLQNSIDPHVSimkVEKAPQETYADIGGLEEQI 191
Cdd:COG1401 108 EADSEIEAVGLLLELAERSDALEALERARLLLE-LADLEERAALETEVLEALEAELEE---LLAAPEDLSADALAAELSA 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 192 QEIKEAVEFPLSHPELYDEVG-------------IKPPKGVILYGVPGTGKTLLAKAVANQTSAT----FLRVV------ 248
Cdd:COG1401 184 AEELYSEDLESEDDYLKDLLRekfeetleaflaaLKTKKNVILAGPPGTGKTYLARRLAEALGGEdngrIEFVQfhpsws 263

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 71653346 249 GSELIQKY---SGDG-----PKLVRELFRVAEENS--PSIVFIDEI 284
Cdd:COG1401 264 YEDFLLGYrpsLDEGkyeptPGIFLRFCLKAEKNPdkPYVLIIDEI 309
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 184-287 2.82e-05

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 46.09  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   184 IGGLEEQIQEIKEAvefplshpeLYDEVGIKPPKGVILYGVPGTGKTLLAKAVANQ----TSATFLRV------------ 247
Cdd:TIGR02928  17 IVHRDEQIEELAKA---------LRPILRGSRPSNVFIYGKTGTGKTAVTKYVMKEleeaAEDRDVRVvtvyvncqildt 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 71653346   248 ---VGSELIQKYSGDGP----------KLVRELFRVAEENSPSIVFI-DEIDAI 287
Cdd:TIGR02928  88 lyqVLVELANQLRGSGEevpttglstsEVFRRLYKELNERGDSLIIVlDEIDYL 141
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 184-350 4.27e-05

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 44.09  E-value: 4.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 184 IGGLEEQIQEIKEAVEfpLSHPELYDEVgiKPPKGVILYGVPGTGKTLLAKAVA---NQTSATFLRVVGSELIQKYS--- 257
Cdd:cd19499  13 VVGQDEAVKAVSDAIR--RARAGLSDPN--RPIGSFLFLGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKHSvsr 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 258 --GDGPKLV--RELFRVAEE---NSPSIVFIDEIDaigtkrydtdsSGAKEVQRTMLELLTqlDGF--DSSN---DVK-- 323
Cdd:cd19499  89 liGAPPGYVgyTEGGQLTEAvrrKPYSVVLLDEIE-----------KAHPDVQNLLLQVLD--DGRltDSHGrtvDFKnt 155

                       170       180
                ....*....|....*....|....*...
gi 71653346 324 -VIMATNrieTLDPALIrpGRIDRKIEF 350
Cdd:cd19499 156 iIIMTSN---HFRPEFL--NRIDEIVVF 178
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 186-374 5.76e-05

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 45.22  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   186 GLEE---QIQEIKEAVEFPLSHPELydevGIKPP---KGVILYGVPGTGKTLLAKAVANQTSA-TFLR------VVGSEL 252
Cdd:TIGR03922 280 GLERvkrQVAALKSSTAMALARAER----GLPVAqtsNHMLFAGPPGTGKTTIARVVAKIYCGlGVLRkplvreVSRADL 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   253 IQKYSGDGPKLVRELFrvaEENSPSIVFIDEIDAIGTKRYDT-DSSGAKEVQRTMLELLTQLD-----GFDSSNDVKVIM 326
Cdd:TIGR03922 356 IGQYIGESEAKTNEII---DSALGGVLFLDEAYTLVETGYGQkDPFGLEAIDTLLARMENDRDrlvviGAGYRKDLDKFL 432

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 71653346   327 ATNrietldPALirPGRIDRKIEFP--FPDEktkkmIFEIhTSRMSLAED 374
Cdd:TIGR03922 433 EVN------EGL--RSRFTRVIEFPsySPDE-----LVEI-ARRMATERD 468
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
219-284 1.55e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 43.58  E-value: 1.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346  219 VILYGVPGTGKTLLAKAVANQTSATfLRVVGSELIQKySGDgpkLVReLFRVAEENspSIVFIDEI 284
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVN-IRITSGPALEK-PGD---LAA-ILTNLEEG--DVLFIDEI 111
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 219-247 1.87e-04

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 41.00  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*....
gi 71653346   219 VILYGVPGTGKTLLAKAVANQTSATFLRV 247
Cdd:pfam07726   2 VLLEGVPGLAKTLLVRTLARSLGLDFRRI 30
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 202-310 2.24e-04

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 42.59  E-value: 2.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 202 LSHPELYDEVGIKPPKG-VILYGVPGTGKTLLAK----------AVANQTSATFLRVVG-------SELIQKYSGDGPKl 263
Cdd:cd19497  35 IRNNLKQKDDDVELEKSnILLIGPTGSGKTLLAQtlakildvpfAIADATTLTEAGYVGedvenilLKLLQAADYDVER- 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 71653346 264 vrelfrvAEEnspSIVFIDEIDAIGTKRYDT----DSSGaKEVQRTMLELL 310
Cdd:cd19497 114 -------AQR---GIVYIDEIDKIARKSENPsitrDVSG-EGVQQALLKIL 153
PRK04195 PRK04195
replication factor C large subunit; Provisional
 173-238 2.65e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.99  E-value: 2.65e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346  173 VEKAPQETYADIGGLEEQIQEIKEAVEFPLSHpelydevgiKPPKGVILYGVPGTGKTLLAKAVAN 238
Cdd:PRK04195   5 VEKYRPKTLSDVVGNEKAKEQLREWIESWLKG---------KPKKALLLYGPPGVGKTSLAHALAN 61
PRK13341 PRK13341
AAA family ATPase;
220-284 5.27e-04

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 42.35  E-value: 5.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  220 ILYGVPGTGKTLLAKAVANQTSATFLrVVGSELiqkysgDGPKLVRELFRVAEE-----NSPSIVFIDEI 284
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHTRAHFS-SLNAVL------AGVKDLRAEVDRAKErlerhGKRTILFIDEV 118
COG2842 COG2842
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ...
 219-383 6.01e-04

Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];


Pssm-ID: 442090 [Multi-domain]  Cd Length: 254  Bit Score: 41.48  E-value: 6.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 219 VILYGVPGTGKTLLAKAVANQ-------------TSATFLRVVGSELiqKYSgDGPKLVRELFRVAEE---NSPSIVFID 282
Cdd:COG2842  53 GVVYGESGVGKTTAAREYANRnpnviyvtaspswTSKELLEELAEEL--GIP-APPGTIADLRDRILErlaGTGRLLIID 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 283 EIDAIGTKrydtdssgakevqrtMLELLTQLdgFDSSNdVKVIMA-TNRIETL---DPALIRpgRIDRKIEF-PFPDEKT 357
Cdd:COG2842 130 EADHLKPK---------------ALEELRDI--HDETG-VGVVLIgMERLPAKlkrYEQLYS--RIGFWVEFkPLSLEDV 189

                       170       180
                ....*....|....*....|....*.
gi 71653346 358 KKMIfeihtSRMSLAEDVDISEFIHA 383
Cdd:COG2842 190 RALA-----EAWGELTDPDLLELLHR 210
AAA_22 pfam13401
AAA domain;
219-327 6.80e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.63  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   219 VILYGVPGTGKTLLAKAVANQ-----------------TSATFLRVVGSEL-IQKYSGDGPKLVRELFR--VAEENSPSI 278
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQlpevrdsvvfvdlpsgtSPKDLLRALLRALgLPLSGRLSKEELLAALQqlLLALAVAVV 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71653346   279 VFIDEIDAIgtkrydtdssgakevQRTMLELLTQLDGFdSSNDVKVIMA 327
Cdd:pfam13401  88 LIIDEAQHL---------------SLEALEELRDLLNL-SSKLLQLILV 120
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 210-283 8.88e-04

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 40.93  E-value: 8.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 210 EVGIKPPKGVI-LYGVPGTGKTLLAKAVANQ---------------TSATFLRVVGSELIQKYSGDGPK-----LVRELF 268
Cdd:COG3267  36 EYALAQGGGFVvLTGEVGTGKTTLLRRLLERlpddvkvayipnpqlSPAELLRAIADELGLEPKGASKAdllrqLQEFLL 115

                        90
                ....*....|....*
gi 71653346 269 RVAEENSPSIVFIDE 283
Cdd:COG3267 116 ELAAAGRRVVLIIDE 130
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
219-274 1.47e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 1.47e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71653346 219 VILYGVPGTGKTLLAKAVANQTSATFLR--VVGSEL-------IQKYSGDGPKLVRELFRVAEEN 274
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLGAVRLRsdVVRKRLfgaglapLERSPEATARTYARLLALAREL 66
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 219-284 2.19e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.64  E-value: 2.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346   219 VILYGVPGTGKTLLAKAVANQTSATFlRVVGSELIQKySGDGPKLVRELfrvaEENspSIVFIDEI 284
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNI-RITSGPAIER-PGDLAAILTNL----EPG--DVLFIDEI 93
PRK12337 PRK12337
2-phosphoglycerate kinase; Provisional
 169-278 2.50e-03

2-phosphoglycerate kinase; Provisional


Pssm-ID: 183452 [Multi-domain]  Cd Length: 475  Bit Score: 40.14  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  169 SIMKVEKAP-------QETYADIGGLEEQI---QEIKEAVefplsHPELYDEVG-------------IKPPKGVILY--G 223
Cdd:PRK12337 188 SLMAAGLAPdvarrlaRETERDLRRSGDRVvrrDQLRRKV-----EALLLEEAGeevarryrllrsiRRPPRPLHVLigG 262

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 71653346  224 VPGTGKTLLAKAVANQTSATflRVVGSEliqkysgdgpkLVRELFR--VAEENSPSI 278
Cdd:PRK12337 263 VSGVGKSVLASALAYRLGIT--RIVSTD-----------AVREVLRamVSKDLLPTL 306
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
213-284 2.95e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 38.99  E-value: 2.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 213 IKPPKGVILYGVPGTGKTLLAKAVANQ-----TSATFLRVvgSELIQKYS---GDGpKLVRELFRVAeenSPSIVFIDEI 284
Cdd:COG1484  96 IERGENLILLGPPGTGKTHLAIALGHEacragYRVRFTTA--PDLVNELKearADG-RLERLLKRLA---KVDLLILDEL 169
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 219-330 3.46e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 37.48  E-value: 3.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346 219 VILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQkysgdgpKLVRELFRVAEENSPSIVFIDEIDAIGTkRYDTDSSG 298
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAEQALLSDEPVIFISFLD-------TILEAIEDLIEEKKLDIIIIDSLSSLAR-ASQGDRSS 72

                        90       100       110
                ....*....|....*....|....*....|..
gi 71653346 299 AkevqrtMLELLTQLDGFDSSNDVKVIMATNR 330
Cdd:cd01120  73 E------LLEDLAKLLRAARNTGITVIATIHS 98
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 186-337 5.03e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 37.87  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346   186 GLEEQIQEIKEAVEFPLSHPelydevgikpPKGVILYGVPGTGKTLLAKAVANQ---TSATFLRVVGSELIQkYSGDGPK 262
Cdd:pfam13191   4 GREEELEQLLDALDRVRSGR----------PPSVLLTGEAGTGKTTLLRELLRAlerDGGYFLRGKCDENLP-YSPLLEA 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71653346   263 LVRE-LFRVAEENSPSIVFIDEIDAIGTKRYDTDSSGAKEVQRtMLELLTQLDGFDSSNDVKVIMATNRIETLDPA 337
Cdd:pfam13191  73 LTREgLLRQLLDELESSLLEAWRAALLEALAPVPELPGDLAER-LLDLLLRLLDLLARGERPLVLVLDDLQWADEA 147
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 217-283 5.25e-03

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 37.51  E-value: 5.25e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71653346 217 KGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYSGDG--PKLVRELFRVAEENSPSIVFIDE 283
Cdd:cd19506  27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGD 95
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
219-310 6.88e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 38.60  E-value: 6.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71653346  219 VILYGVPGTGKTLLAkavanQTSATFLRV---------------VG-------SELIQKYSGDGPKlvrelfrvAEEnsp 276
Cdd:PRK05342 111 ILLIGPTGSGKTLLA-----QTLARILDVpfaiadattlteagyVGedvenilLKLLQAADYDVEK--------AQR--- 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 71653346  277 SIVFIDEIDAIGTK-------RydtDSSGakE-VQRTMLELL 310
Cdd:PRK05342 175 GIVYIDEIDKIARKsenpsitR---DVSG--EgVQQALLKIL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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