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Conserved domains on  [gi|712041857|gb|AIW63867|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Microcebus sambiranensis]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.10e-79

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 233.93  E-value: 1.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGHSVTREDSLGVSALYSYASLLMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712041857 161 FVSVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.10e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 233.93  E-value: 1.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGHSVTREDSLGVSALYSYASLLMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712041857 161 FVSVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 6.47e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.74  E-value: 6.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   21 SKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSSIVIWGALLSGVLME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 712041857  100 LLLMVWLLEHDGVEMVVGfnsledwimfmdkGHSVTREDSLGVsALYSYASLLMVAAGWALFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAA-------------APDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.10e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 233.93  E-value: 1.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGHSVTREDSLGVSALYSYASLLMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712041857 161 FVSVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 1.81e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 111.48  E-value: 1.81e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSsiviWGALLSGVLMELLLMVWLLehdgveMVVGFNSLEDWIMFMDKGHSVTREDSLGVSALYSYASLLMVAAGWAL 160
Cdd:MTH00065  81 AWGS----WSVLVYVLFYLLLLIVGYI------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 712041857 161 FVSVLIVIEIIRG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 2.11e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 108.69  E-value: 2.11e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGALLSGVLmeLLLMVWLLEHDGVEMvvgfnsleDWIMFMD-KGHSVTREDSLGVSALYSYASLLMVAAGWA 159
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVG--VVLAAGLFWGGWYEG--------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 712041857 160 LFVSVLIVIEIIRG 173
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 5.28e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 97.51  E-value: 5.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGALlsGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFmdkghsVTREDSLGVSALYSYASLLMVAAGWAL 160
Cdd:MTH00115  81 AWGDWGVVGYVV--GFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 712041857 161 FVSVLIVIEIIRG 173
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 1.12e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.71  E-value: 1.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 TWGSSIVIWGAL--LSGVLMELLLMVWLLEHDGVEMVVGFNSLEdwimfmdkghsvtredSLGVSALYSYASLLMVAAGW 158
Cdd:MTH00214  81 SWGGWSVLLFFLfyLLGLGFVGFYFYGGWEMLSWMGVDEANNLD----------------LSGVSDLYSRGFFLLLLGGV 144

                        170
                 ....*....|....*
gi 712041857 159 ALFVSVLIVIEIIRG 173
Cdd:MTH00214 145 VLFLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-173 3.40e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 55.68  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   1 MAYTIFLLSTIFVLGFMSFSSkpSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857  81 twgssivIWGALLSGVLMELLLMVWllehdgvemvvGFNSLEDWIMFMDKGHS-VTREDSLGVSALYSYASLLMVAAGWA 159
Cdd:MTH00045  78 -------SVSNLGEVLVLSLLLSLW-----------VFISFDNFLELSNNNWSlVSLSDLVGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|....
gi 712041857 160 LFVSVLIVIEIIRG 173
Cdd:MTH00045 140 LLVALVVALVISFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 6.47e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.74  E-value: 6.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041857   21 SKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSSIVIWGALLSGVLME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 712041857  100 LLLMVWLLEHDGVEMVVGfnsledwimfmdkGHSVTREDSLGVsALYSYASLLMVAAGWALFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAA-------------APDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 1.23e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 40.37  E-value: 1.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712041857   7 LLSTIFVLGFMSFSSKPSPIYGGVALIVSGAVGCSIVMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   5 LLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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