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Conserved domains on  [gi|712041777|gb|AIW63792|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Microcebus myoxinus]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-349 3.47e-150

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 426.57  E-value: 3.47e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318

                        330       340
                 ....*....|....*....|....*....
gi 712041777 321 LKKRPLLLSPLIILSTLSLPLSPMFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-349 3.47e-150

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 426.57  E-value: 3.47e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318

                        330       340
                 ....*....|....*....|....*....
gi 712041777 321 LKKRPLLLSPLIILSTLSLPLSPMFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-299 9.74e-22

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 95.79  E-value: 9.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777    8 IIMMTIFTGTMLTMISSHWLLIWIGLEINMLS--VIPILAKNPKpRSTEAATKYFLTQATASMLLMF----------TIV 75
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCfyVLAGLKRKSR-FSTEAGLKYFILGAFSSGLLLFgisliygftgSLN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   76 FNAMHSGQWTITNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLI---- 151
Cdd:TIGR01770 185 FEDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  152 ---NLNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMfMVLNMNTNTT 228
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALM-SLGAFGVLSL 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  229 TLTLSNLWSKS-----------PTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMR 297
Cdd:TIGR01770 344 LRSYKDEWIEYisdfaglfktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLR 423


                  ..
gi 712041777  298 LI 299
Cdd:TIGR01770 424 VV 425
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-213 2.87e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 91.99  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   23 SSHWLLIWIGLEINMLSVIPILAKNPK-PRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNMD---------PN 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKsPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSkaltgglnsSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   93 NMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLL-TWQKLAPISIMVQMFPLIN-----LNTLMLIALLSVLA 166
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPsspfiQQILLILAIISMLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 712041777  167 GGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLML 213
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLT 207
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-300 4.46e-21

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 93.64  E-value: 4.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   8 IIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIpILA--KNPKPRSTEAATKYFLTQATASMLLMF----------TIV 75
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLY-VLVafRRDDRRSSEAALKYFLLGALSSGFLLYgisllygatgSLN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  76 FNAMHSGQWTITNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPIS----IMVQMFPLI 151
Cdd:COG1007  185 LAGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPGL 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 152 N---LNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSM----TMLNLFIYLMLTITMFMVLNMN 224
Cdd:COG1007  265 AadwQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLL 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 225 TNTTTLTLSN-----LWSKSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:COG1007  345 SRKGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVV 424


                 .
gi 712041777 300 Y 300
Cdd:COG1007  425 K 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-349 3.47e-150

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 426.57  E-value: 3.47e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318

                        330       340
                 ....*....|....*....|....*....
gi 712041777 321 LKKRPLLLSPLIILSTLSLPLSPMFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-348 8.56e-113

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 331.38  E-value: 8.56e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLiNLNTLMLIA 160
Cdd:MTH00135  81 TGQWDIQQM--SHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00135 158 LTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00135 238 ALTALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLP 317

                        330       340
                 ....*....|....*....|....*...
gi 712041777 321 LKKRPLLLSPLIILSTLSLPLSPMFSTL 348
Cdd:MTH00135 318 STQLTLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-343 2.95e-106

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 314.94  E-value: 2.95e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00070  81 TGEWTIMNM--QTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00070 159 LLSTLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00070 239 TLTSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK 318

                        330       340
                 ....*....|....*....|...
gi 712041777 321 LKKrPLLLSPLIILSTLSLPLSP 343
Cdd:MTH00070 319 NKT-NNLLSLTIILSLMLLPITP 340
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-348 3.92e-106

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 314.45  E-value: 3.92e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00112  81 TGQWDITQL--TNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00112 159 ILSTLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00112 239 TLNTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTK 318

                        330       340
                 ....*....|....*....|....*...
gi 712041777 321 LKKRPLLLSPLIILSTLsLPLSPMFSTL 348
Cdd:MTH00112 319 PKKNTLTATLTTLSTLL-LPLSPMILTI 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-309 5.01e-77

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 240.22  E-value: 5.01e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTItnMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00041  81 SGSWSI--NGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00041 159 ILSVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNP 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPT 309
Cdd:MTH00041 239 ISAFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQ 307
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-348 1.03e-75

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 236.79  E-value: 1.03e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITNMdpNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00200  81 SGQWGISEM--LGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00200 159 LLSVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00200 239 ILSMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTK 318

                        330       340
                 ....*....|....*....|....*...
gi 712041777 321 LKKrPLLLSPLIILSTLSLPLSPMFSTL 348
Cdd:MTH00200 319 SNS-NLLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-345 6.17e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 161.91  E-value: 6.17e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMh 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 sgqwtitNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFpliNLNTLMLIA 160
Cdd:MTH00160  81 -------NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLI---NNNFIIIII 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00160 151 ILSAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSK 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFptpNNIKMKWQFQ 320
Cdd:MTH00160 231 KIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNY---NKNKWNLKKK 307

                        330       340
                 ....*....|....*....|....*
gi 712041777 321 LKKRPLLLSPLIILSTLSLPLSPMF 345
Cdd:MTH00160 308 KNKFSLILNFLSFISLFGLILSSLL 332
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-317 3.49e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 154.66  E-value: 3.49e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00144   1 MSSPSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWtitnmdpnnmLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINL-NTLMLI 159
Cdd:MTH00144  81 SFSW----------FSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 160 ALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMvlNMNTNTTTLTLSNLWSKS 239
Cdd:MTH00144 151 SVLSALVGSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFF--SLWSGDSGSMKDLGSLKP 228

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 712041777 240 PTITTMTLISLLSLGG-LPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKW 317
Cdd:MTH00144 229 SYKTGLSIISLLLSLGgLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-301 1.92e-42

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 150.32  E-value: 1.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   1 MKPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00011   3 STFPTMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  81 SGQWTITnmdpnnmlTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIA 160
Cdd:MTH00011  83 PSLLKNI--------TALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 161 LLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSP 240
Cdd:MTH00011 155 AMSALAGGLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQ 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 712041777 241 TITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYS 301
Cdd:MTH00011 235 TTSMSLFIMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 7-302 7.70e-34

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 127.10  E-value: 7.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   7 MIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFtivfnamhsGQWTI 86
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLM---------GGSLS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  87 TNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMvqMFPLINLNTLMLIALLSVLA 166
Cdd:MTH00197  72 FSNLYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLIL--AFNSSSFMGLLICSVLSSLI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 167 GGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSNLWSKSPTITTMT 246
Cdd:MTH00197 150 GGIGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFL 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 712041777 247 LISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYST 302
Cdd:MTH00197 230 GLSFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 4-324 1.30e-24

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 103.94  E-value: 1.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   4 PILMIImmtIFTGTMLTMISSHWLLIWIGLEINMLSVIPILA-KNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSG 82
Cdd:MTH00199 100 PILILI---VALGSLLLVSSINWLSIYLAIELQTLTLFILVAlKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  83 QwtiTNMDPNNMLTS-----FTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLntLM 157
Cdd:MTH00199 177 E---TSIQGINSILTgdvgkILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNV--VL 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 158 LIALLSVLAGGWGGLNQTQLRKILAYSSIAHMG---WMMAILMFCP-SMTMLNLFIYLMLTITMFMVLNMNTNTTTLT-- 231
Cdd:MTH00199 252 ICAVLSIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESiQASLIYMIIYVIMSICSFSIILSLKLTKGLIve 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 232 LSNLWSKSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIystSLTLFPTPN 311
Cdd:MTH00199 332 VSGLSRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRVV---QIIYFQADY 408

                        330
                 ....*....|...
gi 712041777 312 NIkMKWQFQLKKR 324
Cdd:MTH00199 409 SI-LIWQKVLKKE 420
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-299 3.88e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 95.87  E-value: 3.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  16 GTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKP-RSTEAATKYFLTQATASMLLMF--TIVFNAMHSGQWTITNMDPN 92
Cdd:MTH00196   5 GILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSgYSAEAGLKYFVLGALSSGLFLFgcALLCGTTGGLHLSYINLVLN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  93 NMLT---------SFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPliNLNTLMLIALLS 163
Cdd:MTH00196  85 SGQSfssvsvpigYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGGLFS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 164 VLAGGWGGLNQTQLRKILAYSSIAHMG---WMMAILMF-CPSMTMLNLFIYLMLTITMFMVLNMNTNTTTLTLSN--LWS 237
Cdd:MTH00196 163 LFVGAIGALNQTKIKRLLAYSGIGHMGfvlWGIEIGSFeSIQASLVYLFIYIIMSICVFSIILALNVYKNLIIEFsgLSR 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712041777 238 KSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:MTH00196 243 RLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-299 9.74e-22

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 95.79  E-value: 9.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777    8 IIMMTIFTGTMLTMISSHWLLIWIGLEINMLS--VIPILAKNPKpRSTEAATKYFLTQATASMLLMF----------TIV 75
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCfyVLAGLKRKSR-FSTEAGLKYFILGAFSSGLLLFgisliygftgSLN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   76 FNAMHSGQWTITNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLI---- 151
Cdd:TIGR01770 185 FEDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  152 ---NLNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLMLTITMfMVLNMNTNTT 228
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALM-SLGAFGVLSL 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  229 TLTLSNLWSKS-----------PTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMR 297
Cdd:TIGR01770 344 LRSYKDEWIEYisdfaglfktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLR 423


                  ..
gi 712041777  298 LI 299
Cdd:TIGR01770 424 VV 425
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-213 2.87e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 91.99  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   23 SSHWLLIWIGLEINMLSVIPILAKNPK-PRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNMD---------PN 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKsPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSkaltgglnsSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   93 NMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLL-TWQKLAPISIMVQMFPLIN-----LNTLMLIALLSVLA 166
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPsspfiQQILLILAIISMLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 712041777  167 GGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYLML 213
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLT 207
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-300 4.46e-21

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 93.64  E-value: 4.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   8 IIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIpILA--KNPKPRSTEAATKYFLTQATASMLLMF----------TIV 75
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLY-VLVafRRDDRRSSEAALKYFLLGALSSGFLLYgisllygatgSLN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  76 FNAMHSGQWTITNMDPNNMLTSFTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPIS----IMVQMFPLI 151
Cdd:COG1007  185 LAGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPGL 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 152 N---LNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSM----TMLNLFIYLMLTITMFMVLNMN 224
Cdd:COG1007  265 AadwQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLL 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 225 TNTTTLTLSN-----LWSKSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:COG1007  345 SRKGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVV 424


                 .
gi 712041777 300 Y 300
Cdd:COG1007  425 K 425
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
4-299 6.44e-16

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 78.32  E-value: 6.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   4 PILMIIMmtifTGTMLTMISS-HWLLIWIGLEINMLS--VIPILAKNpKPRSTEAATKYFLTQATASMLLMF-------- 72
Cdd:PRK05777 106 YLLVLFA----LLGMMVMVSAnDLLTLFLGLELLSLPlyALAALRRD-RRRSLEAAIKYFVLGALASGFLLYgmsllyga 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  73 --TIVFNAMHSgqwTITNMDPNNMLTSFT---MIIALTMKLGMAPFHFWVPEVTQG-----VSLMTG-------MLLLTW 135
Cdd:PRK05777 181 tgSLSFAGIAK---ALADGSGNSLLLLFGlvfLLVGLAFKLSAVPFHMWTPDVYEGaptpvTAFLATapkiaafAVLLRL 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 136 QKLAPISIMVQMFPLinlntLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMM-AILMFCPSM---TMLNLFIYL 211
Cdd:PRK05777 258 LVVAFGGLSEDWQQV-----LAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLvGLAAGTAEGysaVLFYLLAYL 332

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 212 MLTITMF-MVLNMNTNTTTLTLSNLWS----KSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAI 286
Cdd:PRK05777 333 FMTLGAFgVISLLRRKGGEAESISDFAglskRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVL 412

                        330
                 ....*....|...
gi 712041777 287 MALLNLYFYMRLI 299
Cdd:PRK05777 413 NSAIGAFYYLRVI 425
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 15-303 4.24e-13

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 69.79  E-value: 4.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  15 TGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNM----- 89
Cdd:COG0651  118 AGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLaarla 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  90 --DPNNMLTSFTMI-IALTMKLGMAPFHFWVPEV----TQGVS-LMTGMLLltwqKLAPISIM---VQMFPLINLNT--- 155
Cdd:COG0651  198 elDPGLLLAAFALLlVGFGIKAALFPLHFWLPDAypaaPSPVSaLLSGLLT----KVGVYAILrvlTLLFGADPALFlgt 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 156 -LMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMAILMFCPSMTMLNLFIYL----MLTITMFM----VLNMNTN 226
Cdd:COG0651  274 lLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhaLAKALLFLaagaIERATGT 353

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 712041777 227 TTTLTLSNLWSKSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTS 303
Cdd:COG0651  354 RDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFGRAQ 430
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 16-193 1.08e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 66.04  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  16 GTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRST---------EAATKYFLTQATASMLLMFTIVF---------- 76
Cdd:MTH00198 200 GGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALyfgftgnegm 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  77 -NAMHSGQWTITNMDPNNMLTSFTMI-IALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMfpLINLN 154
Cdd:MTH00198 280 lGTILSATLETTNIELRQGSLGYLFItVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSL--VITSK 357

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 712041777 155 TLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:MTH00198 358 LLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 2-193 2.45e-09

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 58.50  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   2 KPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHS 81
Cdd:PRK12561  85 KPRLFYFLMLVLYSAQIGVFLAQDLLLFFLMWELELVPVYLLISIWGGQKRLYAATKFILYTALASIFILVAGLALALSG 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  82 GQWT--ITNMDPNNMLTSFTM------IIALTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMFP 149
Cdd:PRK12561 165 DTFTfdLAELGAKSYPLALELllyagfLIAFGVKLPIFPLHTWLPdahgEASAPVSMILAGVLLKMGGYALIRFNVQMLP 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 712041777 150 LINLNTLMLIALLSVLAGGWGGLN---QTQLRKILAYSSIAHMGWMM 193
Cdd:PRK12561 245 DAHVYFAPALAILGVVNIIYGALNafaQDNVKRRLAYSSVSHMGFVL 291
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 55-194 4.03e-09

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 57.78  E-value: 4.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  55 AATKYFLTQATASMLLMFTIVFNAMHSGQWTI-------TNMDPN-NMLTSFTMIIALTMKLGMAPFHFWVPEV-----T 121
Cdd:COG1008  162 AAIKFFLYTLAGSLLMLVAILALYFLAGALTFdiaelaaAPLPLTaQLLLFLAFFIAFAVKVPMFPFHTWLPDAhveapT 241

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 712041777 122 QGVSLMTGMLLltwqKLAP---ISIMVQMFP---LINLNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMA 194
Cdd:COG1008  242 AGSVLLAGVLL----KMGGyglLRFALPLFPeasAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLL 316
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 6-193 7.55e-09

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 56.87  E-value: 7.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777    6 LMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNA-MHSGQW 84
Cdd:TIGR01972 108 FYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGVWGGPNRIYAAMKFFLYTLAGSLLMLLAILGLYfLGGGTF 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   85 TITNMDPNNMLTSFTMI------IALTMKLGMAPFHFWVPEV-----TQGVSLMTGMLLltwqKLAPISIMV---QMFP- 149
Cdd:TIGR01972 188 DLLELLNLPLPFGVQTWlflaffIAFAVKVPLFPLHTWLPDAhveapTAGSVILAGVLL----KMGTYGFLRfnlPLFPd 263

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 712041777  150 --LINLNTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:TIGR01972 264 asLYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVL 309
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 55-193 1.60e-07

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 52.90  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  55 AATKYFL-TQAT-----ASMLLMFTIVFNAMHS---GQWTITNMDPN-NMLTSFTMIIALTMKLGMAPFHFWVPEV---- 120
Cdd:PRK05846 162 AATKFFLyTLLGsllmlVAIIYLVVVYYNATGTfdiADLLNLPLPPGvQYWLFLAFFIAFAVKMPMFPLHTWLPDAhvqa 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 121 -TQGVSLMTGMLLltwqKLAP---ISIMVQMFPLINLNTLMLIALLSVLA---GGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK05846 242 pTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEFAPIIITLGVIAiiyGALVALAQTDIKKLIAYSSISHMGFVT 317
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 33-193 7.92e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 50.65  E-value: 7.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  33 LEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQwtiTNM---------DPNNMLTSFTMIIA 103
Cdd:PRK08375 135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGT---LNMadlagalaeNPTVVTAFGFVLLA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 104 LTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMFP------LINLNTLMLIALLSVLAGGWGGLN 173
Cdd:PRK08375 212 LALKAAVFPLHTWLPraypAAPPVVTALLSGLVTKVAVYALIRIYFTVFGgdfrfaLGLGWLLAVLALLSMLVGSLAALG 291

                        170       180
                 ....*....|....*....|
gi 712041777 174 QTQLRKILAYSSIAHMGWMM 193
Cdd:PRK08375 292 QDDVKRVLAYSTVSQMGYIL 311
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
7-265 9.02e-07

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 50.43  E-value: 9.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   7 MIIMMTIFTGTMLTMISSHWLLIWIGLEinMLSVIPILAK---NPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQ 83
Cdd:PRK02504 113 AAILLTATLGGMFLSGATELVMIFISLE--TLSIASYLLTgymKRDPRSNEAALKYLLIGAASSAIFLYGSSLLYGLSGG 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  84 WTITNMDPNNMLTSFTMIIALTM---------KLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLA----PISIMVQMFPL 150
Cdd:PRK02504 191 STQLSAIALALITSPSLGLALALvfviagiafKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPS 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 151 INLN---TLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMMaILMFCP-----SMTMLNLFIYLMLTITMFMVLN 222
Cdd:PRK02504 271 FDEQwklLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVM-IGLVAGteagyASMVFYLLAYLFMNLGAFACVI 349

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 712041777 223 MNTNTTTLTLSNLWS----KSPTITTMTLISLLSLGGLPPLTGFLPK 265
Cdd:PRK02504 350 LFSLRTGTDQISDYAglyqKDPLLTLGLSLCLLSLGGIPPLAGFFGK 396
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 33-193 2.04e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 49.33  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  33 LEINMLSVIPILA-KNPKPRSTEAATKYFLTQATASMLLMFTIvfnAMHSGQWTITNMDPNNMLTSFTM----------- 100
Cdd:PRK08376 150 LEIMSIASYALVAfRNDTWEAIEAGIKYMFVGSLASSMVLLGI---ALLYGQYGTLNMAYLAVKMSENPtvvakialalf 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 101 IIALTMKLGMAPFHFWVPEV-TQGVSLMTGMLLLTWQK--LAPISIMVQMF-PLINLNTL----MLIALLSVLAGGWGGL 172
Cdd:PRK08376 227 IAGLAMKSGAVPVHMWLPDAyPAAPSSISAMLLVIKQAglYALARVLFSIYgPAINLATVgwviIILGCLTMFVGVAMAV 306

                        170       180
                 ....*....|....*....|.
gi 712041777 173 NQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK08376 307 VQKDVKRLLAYHSVSQIGYML 327
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 293-343 4.23e-06

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 43.40  E-value: 4.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 712041777  293 YFYMRLIYSTSLTLFPTPNNIKMKWQFQLKKRPLLLSPLIILSTLSLPLSP 343
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 98-319 8.14e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 43.71  E-value: 8.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  98 FTMIIALTMKLGMAPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMVQMFPLINLNTLMLIALLSVLAggwgGLNQTQL 177
Cdd:MTH00091  61 YFQFLILMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICFFQ----MFLLKSY 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 178 RKILAYSSIAHMGWMMAILMFCPSMTMlnlFIYLMLTITMFMVlnmntntttltlSNLWSKSPTITTMTLISLLSLGGLP 257
Cdd:MTH00091 137 KNLLILSSTESFNWLILSFFFSFFNVF---FLFFYYFLLMLFL------------IPKFNNVNKLNFVSWETLLVFMNLP 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712041777 258 PLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQF 319
Cdd:MTH00091 202 FSVTFFVKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFF 263
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
100-193 1.09e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 43.92  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 100 MIIALTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMFP---LINLNTLMLIALLSVLAGGWGGL 172
Cdd:PRK06473 211 ILVGFGIKIPLVPFHTWLPdahvEASTPVSVLLAGVLLKLGTYGLLRFGVGLFPeawVYLAPWLATWAVVSVLYGASCAI 290

                         90       100
                 ....*....|....*....|.
gi 712041777 173 NQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK06473 291 AQKDMKKMVAYSSIGHMGYIL 311
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 10-192 1.29e-04

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 43.77  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  10 MMTIFTGTM-LTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFL------TQATASMLLMFTIVFNAMHSG 82
Cdd:PRK06458 113 MYQLFLFTMlLALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVMGDG 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  83 Q----WTITN-----MDPNNMLTSFTMI-IALTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMF 148
Cdd:PRK06458 193 EmailWTELLkhaslLDPTLMKLAFVFLlIGFGTKVGLFPMHAWLPdahsEAPSPVSALLSGVLLNVALYAVLRYYILID 272

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 712041777 149 PLIN---LNTLMLI-ALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWM 192
Cdd:PRK06458 273 AAIGsdfPGRLLLIfGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLI 320
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 17-193 4.09e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 42.05  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  17 TMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATA------SMLLMFTIVFNAMHSG--QWT--- 85
Cdd:PRK08676 115 ITFAFFSDNLALFWIFAELTTVFSAMLIAILSARENIDAALKYIFIASTAmifafiGLIFLFSLTRQALGTGtlNWTela 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  86 --ITNMDPNNMLTSFT-MIIALTMKLGMAPFHFWVPEV-TQGVSLMTGMLLLTWQKLAPISImVQMFPLIN--------L 153
Cdd:PRK08676 195 ahASLLSPSVLGASFLfIFIGFLAKSGLVPFHTWLPAAyAKAPSVVSALLSGTVLNIGIYGI-LRLSALLRqsgaaeqfS 273

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 712041777 154 NTLMLIALLSVLAGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK08676 274 NVLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLML 313
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 102-213 4.78e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 41.96  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 102 IALTMKLGMAPFHFWVPEV-----TQGVSLMTGMLLltwqKLAPISIMVQMFPLINLNTLM---LIALLSVLAGGWGGLN 173
Cdd:MTH00217 214 LSLAIKIPKIPFHIWLPQAhveapVAGSVILAGVLL----KLGGYGFIRFSWPLLPEASEYfspLIQTLSLLAIIYGSLT 289

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 712041777 174 ---QTQLRKILAYSSIAHMGwMMAILMFCPSMTMLNLFIYLML 213
Cdd:MTH00217 290 tcrQVDLKRIIAYSSVAHMG-LVTLGIFSHTIQGLVAAIFLML 331
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 2-193 8.36e-04

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 41.23  E-value: 8.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777   2 KPPILMIIMMTIFTGTMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHS 81
Cdd:PRK02546 113 KPKLFYFLMLAMYGGQIAVFAVQDMLLFFLAWELELIPVYLLLAIWGGKKRQYAATKFILYTAGSSLFILLAALAMAFYG 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  82 GQWT--ITNMDPNNMLTSFTM------IIALTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMFP 149
Cdd:PRK02546 193 DTPTfdMTALAAKDFGLGFQLlcyaglLIAYGVKLPIVPLHTWLPdahgEATAPVHMLLAGILLKMGGYALLRMNAGMLP 272

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 712041777 150 LINLNTLMLIALLSVLAGGWGGLN---QTQLRKILAYSSIAHMGWMM 193
Cdd:PRK02546 273 DAHAQFAPLLIVLGVVNIIYAALTsfaQRNLKRKIAYSSISHMGFVL 319
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
100-193 9.67e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 40.85  E-value: 9.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 100 MIIALTMKLGMAPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMVQMFP---LINLNTLMLIALLSVLAGGWGGL 172
Cdd:PRK07363 211 LLLGFGIKIPLVPLHTWLPdaytEASPAVAILLGGVLAKLGTYGLLRFGLQLFPqtwSLVAPGLAIIGTISVIYGALSAI 290

                         90       100
                 ....*....|....*....|.
gi 712041777 173 NQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK07363 291 AQKDIKRMVAYSSIGHMGYIL 311
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 102-213 1.09e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 40.82  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 102 IALTMKLGMAPFHFWVPEV-----TQGVSLMTGMLLltwqKLAPISIMVQMFPLINLNTLM---LIALLSVLAGGWGGL- 172
Cdd:MTH00204 217 LSLAVKIPQIPFHIWLPQAhveapVAGSVILAGILL----KLGGYGFLRFSWPLFPAASEYfapLIVMLSVIAVIYGSLt 292

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 712041777 173 --NQTQLRKILAYSSIAHMGwMMAILMFCPSMTMLNLFIYLML 213
Cdd:MTH00204 293 tcRQVDFKRLIAYSSVAHMG-LVPLGLFTHTIEGLVAAVFLML 334
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 17-301 2.11e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 39.80  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  17 TMLTMISSHWLLIWIGLEINMLSVIPILAKNPKPRSTEAATKYFLTQATASMLLMFT---IVFNAMHSGQWTITNM-DPN 92
Cdd:PRK06589 129 GVLIALSSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLPaviLIYTKTGNLDFVSGGLfSKN 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  93 NMLTSFTMIIALTMKLGMAPFHFWVPEV----TQGVSLMTGMLLLTWQKLAPISIMVQMFPLINL-------NTLMLIAL 161
Cdd:PRK06589 209 QSIILLLMFIYGIAKTAIFPVHSWLPAAmvahYPVSALLHAVIVVKTGLFCIYKILLYIFGLSYLqrifaefNWLIFIPI 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 162 LSVLAGGWGGLNQTQLRKILAYSSIAHMGWMM--AILMFCPSM--TMLNLFIYLMLTITMFMVLNMNTNTT----TLTLS 233
Cdd:PRK06589 289 VSIFYSSLKALKTDNIKKILAYSTISQLSLALlsAFILTPKALgaAILHLVSHSFAKICLFYSMGSIYSLKkedqVDKLH 368

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712041777 234 NLWSKSPTITTMTLISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIM----ALLNLYFYMRLIYS 301
Cdd:PRK06589 369 GTSKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMLVviasSILSALYLLKILSS 440
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 100-213 2.99e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 39.52  E-value: 2.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 100 MIIALTMKLGMAPFHFWVPEV-----TQGVSLMTGMLLltwqKLAPISIMVQMFPLINLNT------LMLIALLSVLAGG 168
Cdd:MTH00226 236 IFLAMAVKIPIFPFHIWLPKAhveapVAGSVLLAGILL----KLGGYGLVRLSWPILPLGAqnlapaVIAMGIVGIVYGS 311

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 712041777 169 WGGLNQTQLRKILAYSSIAHMGwMMAILMFCPSMTMLNLFIYLML 213
Cdd:MTH00226 312 FATCRQIDVKRLVAYSSVAHMG-LVSITLVTHDIIGLTGSIFIML 355
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 49-301 5.51e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 38.41  E-value: 5.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777  49 KPRSTEAATKYFLTQATASMLLMFTIVF--------------NAMHSGQWTITNMDPNNMLTSFTMIIAL-----TMKLG 109
Cdd:PRK12667 159 RGDAVEAAIKYALIGAVGTTLYFLALAFlyatfgtlnmadlsAKIRGLSFPLTGGLAGNPPLALGVALALalwafTIKAA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 110 MAPFHFWVPEV----TQGVSLMTGMLLLTWQKLAPISIMVQMF-------PLIN--LNTLMLIALLSVLAGGWGGLNQTQ 176
Cdd:PRK12667 239 IFPNHFWLPDAhpaaPSPVSAMLSGLVVNVGAYAIIRFLYTIFgispsliDFRAalSPILIILGAVSAIIGALMMVVQKD 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041777 177 LRKILAYSSIAHMGW-MMAILMfcPSMTMLNLFIYL---------MLTITMFMVLNMNTNTTTLTLSNLWSKSPTITTMT 246
Cdd:PRK12667 319 VKRLLAYSTISHMGYiFMGIGI--GTQLGLAAALFHiinhaiaksLLFLASGVFIHAAGTRDIDELAGLGRKMPIASFAF 396

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 712041777 247 LISLLSLGGLPPLTGFLPKWLIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYS 301
Cdd:PRK12667 397 LIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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