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Conserved domains on  [gi|712041735|gb|AIW63753|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Microcebus tanosi]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-349 3.69e-151

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 428.88  E-value: 3.69e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIdsNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318
                        330       340
                 ....*....|....*....|....*....
gi 712041735 321 LKKRSLLLSPLIILSTLSLPLSPVFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-349 3.69e-151

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 428.88  E-value: 3.69e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIdsNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318
                        330       340
                 ....*....|....*....|....*....
gi 712041735 321 LKKRSLLLSPLIILSTLSLPLSPVFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
8-299 2.45e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 94.63  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735    8 IIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILA-KNPKPRSTEAATKYFLTQATASMLLMF----------TIVF 76
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFgisliygftgSLNF 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   77 NAMHSGQWTITNIDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSI----- 151
Cdd:TIGR01770 186 EDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfs 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  152 --NLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTT 229
Cdd:TIGR01770 266 eaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  230 LT----------LSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:TIGR01770 346 SYkdewieyisdFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
23-213 4.76e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 91.61  E-value: 4.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   23 SSHWLLIWIGLEINMLSIIPILAKNPK-PRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNID---------SN 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKsPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSkaltgglnsSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   93 NMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLL-TWQKLAPISIMIQMFPSIN-----LNILMLIALLSVLT 166
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPsspfiQQILLILAIISMLL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 712041735  167 GGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLML 213
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLT 207
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
4-300 5.19e-21

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 93.64  E-value: 5.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   4 PILMIIMTTifmGTMLTMISSHWLLIWIGLEINMLSIIpILA--KNPKPRSTEAATKYFLTQATASMLLMF--------- 72
Cdd:COG1007  105 YALLLFATL---GMMLMASANDLLTLFLGLELLSLSLY-VLVafRRDDRRSSEAALKYFLLGALSSGFLLYgisllygat 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  73 -TIVFNAMhsGQWTITNIDSNNMLISST--MIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPIS----IMI 145
Cdd:COG1007  181 gSLNLAGI--AAALAAGGANSPLLLLGLvlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLV 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 146 QMFPSINLNILMLIALLSVLT---GGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSM----TMLNLFIYLMLTITMF 218
Cdd:COG1007  259 EAFPGLAADWQLLLAVLAVLSmtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAF 338
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 219 TMLNMNTNTTTLTLS-----SLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLY 293
Cdd:COG1007  339 AVILLLSRKGGEAEEiedlaGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAY 418

                 ....*..
gi 712041735 294 FYMRLIY 300
Cdd:COG1007  419 YYLRVVK 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-349 3.69e-151

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 428.88  E-value: 3.69e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIdsNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00105  81 SGQWTITKL--TNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00105 159 ILSILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00105 239 LMTSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFE 318
                        330       340
                 ....*....|....*....|....*....
gi 712041735 321 LKKRSLLLSPLIILSTLSLPLSPVFSTLN 349
Cdd:MTH00105 319 NTKPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
1-348 1.11e-111

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 328.69  E-value: 1.11e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIdsNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSiNLNILMLIA 160
Cdd:MTH00135  81 TGQWDIQQM--SHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00135 158 LTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAP 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00135 238 ALTALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLP 317
                        330       340
                 ....*....|....*....|....*...
gi 712041735 321 LKKRSLLLSPLIILSTLSLPLSPVFSTL 348
Cdd:MTH00135 318 STQLTLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
1-343 8.94e-106

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 313.78  E-value: 8.94e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIDSNNMLISSTMivALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTI--ALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00070 159 LLSTLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00070 239 TLTSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK 318
                        330       340
                 ....*....|....*....|...
gi 712041735 321 LKKrSLLLSPLIILSTLSLPLSP 343
Cdd:MTH00070 319 NKT-NNLLSLTIILSLMLLPITP 340
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
1-348 3.66e-104

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 309.45  E-value: 3.66e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNIdsNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00112  81 TGQWDITQL--TNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00112 159 ILSTLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00112 239 TLNTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTK 318
                        330       340
                 ....*....|....*....|....*...
gi 712041735 321 LKKRSLLLSPLIILSTLsLPLSPVFSTL 348
Cdd:MTH00112 319 PKKNTLTATLTTLSTLL-LPLSPMILTI 345
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
1-348 5.31e-75

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 235.25  E-value: 5.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITniDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00200  81 SGQWGIS--EMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00200 159 LLSVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQ 320
Cdd:MTH00200 239 ILSMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTK 318
                        330       340
                 ....*....|....*....|....*...
gi 712041735 321 LKKrSLLLSPLIILSTLSLPLSPVFSTL 348
Cdd:MTH00200 319 SNS-NLLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
1-309 4.84e-74

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 232.51  E-value: 4.84e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTItnIDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00041  81 SGSWSI--NGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00041 159 ILSVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNP 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPT 309
Cdd:MTH00041 239 ISAFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQ 307
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
1-345 1.13e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 161.14  E-value: 1.13e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMh 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 sgqwtitNIDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFpsiNLNILMLIA 160
Cdd:MTH00160  81 -------NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLI---NNNFIIIII 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00160 151 ILSAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFptpNNIKMKWQFQ 320
Cdd:MTH00160 231 KIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNY---NKNKWNLKKK 307
                        330       340
                 ....*....|....*....|....*
gi 712041735 321 LKKRSLLLSPLIILSTLSLPLSPVF 345
Cdd:MTH00160 308 KNKFSLILNFLSFISLFGLILSSLL 332
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
1-317 2.89e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 154.66  E-value: 2.89e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00144   1 MSSPSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWtitnidsnnmLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINL-NILMLI 159
Cdd:MTH00144  81 SFSW----------FSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVI 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 160 ALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLwSKS 239
Cdd:MTH00144 151 SVLSALVGSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPS 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 712041735 240 PTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKW 317
Cdd:MTH00144 230 YKTGLSIISLLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
1-301 9.23e-44

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 153.78  E-value: 9.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   1 MKPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:MTH00011   3 STFPTMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNidsnnmliSSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIA 160
Cdd:MTH00011  83 PSLLKNIT--------ALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSP 240
Cdd:MTH00011 155 AMSALAGGLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQ 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 712041735 241 TITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYS 301
Cdd:MTH00011 235 TTSMSLFIMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
7-302 3.06e-34

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 128.25  E-value: 3.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   7 MIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFtivfnamhsGQWTI 86
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLM---------GGSLS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  87 TNIDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPIsiMIQMFPSINLNILMLIALLSVLT 166
Cdd:MTH00197  72 FSNLYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPL--LILAFNSSSFMGLLICSVLSSLI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 167 GGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTLSSLWSKSPTITTMI 246
Cdd:MTH00197 150 GGIGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 712041735 247 LVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYST 302
Cdd:MTH00197 230 GLSFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
4-324 5.26e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 105.10  E-value: 5.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   4 PILMIIMTtifMGTMLTMISSHWLLIWIGLEINMLSIIPILA-KNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSG 82
Cdd:MTH00199 100 PILILIVA---LGSLLLVSSINWLSIYLAIELQTLTLFILVAlKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTG 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  83 QwtiTNIDSNNMLISST-----MIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINlnILM 157
Cdd:MTH00199 177 E---TSIQGINSILTGDvgkilITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTN--VVL 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 158 LIALLSVLTGGWGGLNQTQLRKILAYSSIAHMG---WMMTILMFCP-SMTMLNLFIYLMLTITMFTMLNMNTNTTTLT-- 231
Cdd:MTH00199 252 ICAVLSIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESiQASLIYMIIYVIMSICSFSIILSLKLTKGLIve 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 232 LSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIystSLTLFPTPN 311
Cdd:MTH00199 332 VSGLSRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRVV---QIIYFQADY 408
                        330
                 ....*....|...
gi 712041735 312 NIkMKWQFQLKKR 324
Cdd:MTH00199 409 SI-LIWQKVLKKE 420
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
13-299 1.90e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 96.64  E-value: 1.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  13 IFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKP-RSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNID- 90
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSgYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLSYINl 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  91 --SNNMLISSTM--------IVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPsiNLNILMLIA 160
Cdd:MTH00196  82 vlNSGQSFSSVSvpigylliIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 161 LLSVLTGGWGGLNQTQLRKILAYSSIAHMG---WMMTILMF-CPSMTMLNLFIYLMLTITMFTMLNMNTNTTTLTL--SS 234
Cdd:MTH00196 160 LFSLFVGAIGALNQTKIKRLLAYSGIGHMGfvlWGIEIGSFeSIQASLVYLFIYIIMSICVFSIILALNVYKNLIIefSG 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 712041735 235 LWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:MTH00196 240 LSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
8-299 2.45e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 94.63  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735    8 IIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILA-KNPKPRSTEAATKYFLTQATASMLLMF----------TIVF 76
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFgisliygftgSLNF 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   77 NAMHSGQWTITNIDSNNMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSI----- 151
Cdd:TIGR01770 186 EDLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfs 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  152 --NLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMLNMNTNTTT 229
Cdd:TIGR01770 266 eaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  230 LT----------LSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLI 299
Cdd:TIGR01770 346 SYkdewieyisdFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
23-213 4.76e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 91.61  E-value: 4.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   23 SSHWLLIWIGLEINMLSIIPILAKNPK-PRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNID---------SN 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKsPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSkaltgglnsSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   93 NMLISSTMIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLL-TWQKLAPISIMIQMFPSIN-----LNILMLIALLSVLT 166
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPsspfiQQILLILAIISMLL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 712041735  167 GGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYLML 213
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLT 207
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
4-300 5.19e-21

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 93.64  E-value: 5.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   4 PILMIIMTTifmGTMLTMISSHWLLIWIGLEINMLSIIpILA--KNPKPRSTEAATKYFLTQATASMLLMF--------- 72
Cdd:COG1007  105 YALLLFATL---GMMLMASANDLLTLFLGLELLSLSLY-VLVafRRDDRRSSEAALKYFLLGALSSGFLLYgisllygat 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  73 -TIVFNAMhsGQWTITNIDSNNMLISST--MIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPIS----IMI 145
Cdd:COG1007  181 gSLNLAGI--AAALAAGGANSPLLLLGLvlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLV 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 146 QMFPSINLNILMLIALLSVLT---GGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSM----TMLNLFIYLMLTITMF 218
Cdd:COG1007  259 EAFPGLAADWQLLLAVLAVLSmtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAF 338
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 219 TMLNMNTNTTTLTLS-----SLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLY 293
Cdd:COG1007  339 AVILLLSRKGGEAEEiedlaGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAY 418

                 ....*..
gi 712041735 294 FYMRLIY 300
Cdd:COG1007  419 YYLRVVK 425
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
4-299 1.12e-16

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 80.64  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   4 PILMIIMTtifmGTMLTMISS-HWLLIWIGLEINMLS--IIPILAKNpKPRSTEAATKYFLTQATASMLLMFTIVFNAMH 80
Cdd:PRK05777 106 YLLVLFAL----LGMMVMVSAnDLLTLFLGLELLSLPlyALAALRRD-RRRSLEAAIKYFVLGALASGFLLYGMSLLYGA 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  81 SGQWTITNI--------DSNNMLISST--MIVALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMF-- 148
Cdd:PRK05777 181 TGSLSFAGIakaladgsGNSLLLLFGLvfLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLLvv 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 149 -----PSINLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSM----TMLNLFIYLMLTITMFT 219
Cdd:PRK05777 261 afgglSEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLGAFG 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 220 MLNMNTNTTTLT-----LSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYF 294
Cdd:PRK05777 341 VISLLRRKGGEAesisdFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFY 420

                 ....*
gi 712041735 295 YMRLI 299
Cdd:PRK05777 421 YLRVI 425
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
15-303 1.71e-12

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 67.86  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  15 MGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNIDSNNM 94
Cdd:COG0651  118 AGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLAARLA 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  95 LISST--------MIVALTMKLGMTPFHFWVPEV----TQGVS-LMTGMLLltwqKLAPISIM---IQMFPSINLN---- 154
Cdd:COG0651  198 ELDPGlllaafalLLVGFGIKAALFPLHFWLPDAypaaPSPVSaLLSGLLT----KVGVYAILrvlTLLFGADPALflgt 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 155 ILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYL----MLTITMF----TMLNMNTN 226
Cdd:COG0651  274 LLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhaLAKALLFlaagAIERATGT 353
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 712041735 227 TTTLTLSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTS 303
Cdd:COG0651  354 RDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFGRAQ 430
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
15-193 7.58e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 66.42  E-value: 7.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  15 MGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRST---------EAATKYFLTQATASMLLMFTIVF--------- 76
Cdd:MTH00198 199 LGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALyfgftgneg 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  77 --NAMHSGQWTITNIDSNNMLISSTMI-VALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFpsINL 153
Cdd:MTH00198 279 mlGTILSATLETTNIELRQGSLGYLFItVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLV--ITS 356
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 712041735 154 NILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:MTH00198 357 KLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
55-193 1.52e-09

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 58.94  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  55 AATKYFLTQATASMLLMFTIVFNAMHSGQWTITNIDSNNMLISSTM--------IVALTMKLGMTPFHFWVPEV-----T 121
Cdd:COG1008  162 AAIKFFLYTLAGSLLMLVAILALYFLAGALTFDIAELAAAPLPLTAqlllflafFIAFAVKVPMFPFHTWLPDAhveapT 241
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 712041735 122 QGVSLMTGMLLltwqKLAP---ISIMIQMFP---SINLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:COG1008  242 AGSVLLAGVLL----KMGGyglLRFALPLFPeasAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVL 315
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
2-193 4.19e-09

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 57.73  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   2 KPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHS 81
Cdd:PRK12561  85 KPRLFYFLMLVLYSAQIGVFLAQDLLLFFLMWELELVPVYLLISIWGGQKRLYAATKFILYTALASIFILVAGLALALSG 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  82 GQWT--ITNIDSNN------MLISSTMIVALTMKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMFP 149
Cdd:PRK12561 165 DTFTfdLAELGAKSyplaleLLLYAGFLIAFGVKLPIFPLHTWLPdahgEASAPVSMILAGVLLKMGGYALIRFNVQMLP 244
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 712041735 150 SINLNILMLIALLSVLTGGWGGLN---QTQLRKILAYSSIAHMGWMM 193
Cdd:PRK12561 245 DAHVYFAPALAILGVVNIIYGALNafaQDNVKRRLAYSSVSHMGFVL 291
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
7-265 2.16e-08

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 55.44  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   7 MIIMTTIFMGTMLTMISSHWLLIWIGLEinMLSIIPILAK---NPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQ 83
Cdd:PRK02504 113 AAILLTATLGGMFLSGATELVMIFISLE--TLSIASYLLTgymKRDPRSNEAALKYLLIGAASSAIFLYGSSLLYGLSGG 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  84 WTITNIDSNNMLISSTMIVALTM---------KLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLA----PISIMIQMFPS 150
Cdd:PRK02504 191 STQLSAIALALITSPSLGLALALvfviagiafKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPS 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 151 INLN---ILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMtILMFCP-----SMTMLNLFIYLMLTITMFTMLN 222
Cdd:PRK02504 271 FDEQwklLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVM-IGLVAGteagyASMVFYLLAYLFMNLGAFACVI 349
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 712041735 223 MNTNTT----TLTLSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPK 265
Cdd:PRK02504 350 LFSLRTgtdqISDYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGK 396
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
33-193 8.43e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 53.73  E-value: 8.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  33 LEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGqwTITNIDSNNMLISST--------MIVAL 104
Cdd:PRK08375 135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTG--TLNMADLAGALAENPtvvtafgfVLLAL 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 105 TMKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMFP------SINLNILMLIALLSVLTGGWGGLNQ 174
Cdd:PRK08375 213 ALKAAVFPLHTWLPraypAAPPVVTALLSGLVTKVAVYALIRIYFTVFGgdfrfaLGLGWLLAVLALLSMLVGSLAALGQ 292
                        170
                 ....*....|....*....
gi 712041735 175 TQLRKILAYSSIAHMGWMM 193
Cdd:PRK08375 293 DDVKRVLAYSTVSQMGYIL 311
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
6-193 9.68e-08

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 53.40  E-value: 9.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735    6 LMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNA-MHSGQW 84
Cdd:TIGR01972 108 FYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGVWGGPNRIYAAMKFFLYTLAGSLLMLLAILGLYfLGGGTF 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   85 TITNIDSNNMLISSTMI------VALTMKLGMTPFHFWVPEV-----TQGVSLMTGMLLltwqKLAPISIM---IQMFPS 150
Cdd:TIGR01972 188 DLLELLNLPLPFGVQTWlflaffIAFAVKVPLFPLHTWLPDAhveapTAGSVILAGVLL----KMGTYGFLrfnLPLFPD 263
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 712041735  151 ---INLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:TIGR01972 264 aslYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVL 309
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
55-193 1.11e-06

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 50.20  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  55 AATKYFL-TQAT-----ASMLLMFTIVFNAMHS---GQWTITNIDSN-NMLISSTMIVALTMKLGMTPFHFWVPEV---- 120
Cdd:PRK05846 162 AATKFFLyTLLGsllmlVAIIYLVVVYYNATGTfdiADLLNLPLPPGvQYWLFLAFFIAFAVKMPMFPLHTWLPDAhvqa 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 121 -TQGVSLMTGMLLltwqKLAP---ISIMIQMFPSINLN---ILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK05846 242 pTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEfapIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVT 317
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
33-193 3.15e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 48.55  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  33 LEINMLSIIPILA-KNPKPRSTEAATKYFLTQATASMLLMFTIvfnAMHSGQWTITNIDSNNMLISSTM----------- 100
Cdd:PRK08376 150 LEIMSIASYALVAfRNDTWEAIEAGIKYMFVGSLASSMVLLGI---ALLYGQYGTLNMAYLAVKMSENPtvvakialalf 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 101 IVALTMKLGMTPFHFWVPEV-TQGVSLMTGMLLLTWQ----KLAPISIMIqMFPSINLN----ILMLIALLSVLTGGWGG 171
Cdd:PRK08376 227 IAGLAMKSGAVPVHMWLPDAyPAAPSSISAMLLVIKQaglyALARVLFSI-YGPAINLAtvgwVIIILGCLTMFVGVAMA 305
                        170       180
                 ....*....|....*....|..
gi 712041735 172 LNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK08376 306 VVQKDVKRLLAYHSVSQIGYML 327
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
293-343 3.69e-06

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 43.40  E-value: 3.69e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 712041735  293 YFYMRLIYSTSLTLFPTPNNIKMKWQFQLKKRSLLLSPLIILSTLSLPLSP 343
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
12-193 1.97e-05

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 46.30  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  12 TIFMGTMLTM-ISSHWLLIWIGLEI-NMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTITNI 89
Cdd:COG1009  118 LLFMAAMLGLvLSDNLLLLFVFWELvGLCSYLLIGFWYEKPSARRAARKAFLVTRVGDLGLLLGILLLGAIAGTLNFSEL 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  90 DSN-NMLISSTMIVALTM--------KLGMTPFHFWVPE-----------------VTQGVSLMTgmllltwqKLAPISI 143
Cdd:COG1009  198 LAAaPTILSSPLLTLILLllllgafgKSAQFPLHFWLPDamegptpvsallhaatmVKAGVYLLA--------RLSPLFA 269
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 712041735 144 MIQMFpsinLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:COG1009  270 LSPVW----LTVVAIIGAITALFAALIALAQTDIKRVLAYSTVSQLGYMF 315
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
91-193 3.12e-05

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 45.46  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  91 SNNMLISSTMIVALTMKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNI---LMLIALLS 163
Cdd:PRK06473 202 STQLLLLAPILVGFGIKIPLVPFHTWLPdahvEASTPVSVLLAGVLLKLGTYGLLRFGVGLFPEAWVYLapwLATWAVVS 281
                         90       100       110
                 ....*....|....*....|....*....|
gi 712041735 164 VLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK06473 282 VLYGASCAIAQKDMKKMVAYSSIGHMGYIL 311
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
85-193 3.20e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 42.39  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  85 TITNIDSNNMLISSTMI-VALTMKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMFP---SINLNIL 156
Cdd:PRK07363 195 STQNLSLNTQLILLTGLlLGFGIKIPLVPLHTWLPdaytEASPAVAILLGGVLAKLGTYGLLRFGLQLFPqtwSLVAPGL 274
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 712041735 157 MLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMM 193
Cdd:PRK07363 275 AIIGTISVIYGALSAIAQKDIKRMVAYSSIGHMGYIL 311
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
10-192 4.20e-04

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 41.84  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  10 MTTIFMGTML-TMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFL------TQATASMLLMFTIVFNAMHSG 82
Cdd:PRK06458 113 MYQLFLFTMLlALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIicsvgvAFALFGTILVYANAATVMGDG 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  83 QWTI--TNIDS-----NNMLISSTMIVALT---MKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMF 148
Cdd:PRK06458 193 EMAIlwTELLKhasllDPTLMKLAFVFLLIgfgTKVGLFPMHAWLPdahsEAPSPVSALLSGVLLNVALYAVLRYYILID 272
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 712041735 149 PSINL----NILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWM 192
Cdd:PRK06458 273 AAIGSdfpgRLLLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLI 320
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
102-213 4.22e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 41.96  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 102 VALTMKLGMTPFHFWVPEV-----TQGVSLMTGMLLltwqKLAP---ISIMIQMFPSINLNILMLIALLSVLTGGWGGLN 173
Cdd:MTH00217 214 LSLAIKIPKIPFHIWLPQAhveapVAGSVILAGVLL----KLGGygfIRFSWPLLPEASEYFSPLIQTLSLLAIIYGSLT 289
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 712041735 174 ---QTQLRKILAYSSIAHMGwMMTILMFCPSMTMLNLFIYLML 213
Cdd:MTH00217 290 tcrQVDLKRIIAYSSVAHMG-LVTLGIFSHTIQGLVAAIFLML 331
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
104-319 8.34e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 40.62  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 104 LTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSINLNILMLIALLSVLTggwgGLNQTQLRKILAY 183
Cdd:MTH00091  67 LMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICFFQ----MFLLKSYKNLLIL 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 184 SSIAHMGWMMTILMFCPSMTMLNLFIYLMLTITMFTMlnmntntttltlsslWSKSPTITTMILVSLLSLGGLPPLTGFL 263
Cdd:MTH00091 143 SSTESFNWLILSFFFSFFNVFFLFFYYFLLMLFLIPK---------------FNNVNKLNFVSWETLLVFMNLPFSVTFF 207
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 712041735 264 PKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQF 319
Cdd:MTH00091 208 VKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFF 263
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
17-194 8.87e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 40.89  E-value: 8.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  17 TMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATA------SMLLMFTIVFNAMHSGQWTITNID 90
Cdd:PRK08676 115 ITFAFFSDNLALFWIFAELTTVFSAMLIAILSARENIDAALKYIFIASTAmifafiGLIFLFSLTRQALGTGTLNWTELA 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  91 SNNMLISSTMIVA--------LTMKLGMTPFHFWVPEV-TQGVSLMTGMLLLTWQKLAPISImIQMFP--------SINL 153
Cdd:PRK08676 195 AHASLLSPSVLGAsflfifigFLAKSGLVPFHTWLPAAyAKAPSVVSALLSGTVLNIGIYGI-LRLSAllrqsgaaEQFS 273
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 712041735 154 NILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMT 194
Cdd:PRK08676 274 NVLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLL 314
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
49-301 9.55e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 41.11  E-value: 9.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  49 KPRSTEAATKYFLTQATASMLLMFTIVF--------------NAMHSGQWTITNIDSNNMLISSTMIVAL-----TMKLG 109
Cdd:PRK12667 159 RGDAVEAAIKYALIGAVGTTLYFLALAFlyatfgtlnmadlsAKIRGLSFPLTGGLAGNPPLALGVALALalwafTIKAA 238
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 110 MTPFHFWVPEV----TQGVSLMTGMLLLTWQKLAPISIMIQMFP---------SINLNILMLIALLSVLTGGWGGLNQTQ 176
Cdd:PRK12667 239 IFPNHFWLPDAhpaaPSPVSAMLSGLVVNVGAYAIIRFLYTIFGispslidfrAALSPILIILGAVSAIIGALMMVVQKD 318
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 177 LRKILAYSSIAHMGWMMTILMFCPSMTMLNLFIYL--------MLTITMFTMLNMNTNTTTLTLSSLWSKSPTITTMILV 248
Cdd:PRK12667 319 VKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIinhaiaksLLFLASGVFIHAAGTRDIDELAGLGRKMPIASFAFLI 398
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 712041735 249 SLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIMALLNLYFYMRLIYS 301
Cdd:PRK12667 399 GALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
102-213 1.76e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 40.05  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 102 VALTMKLGMTPFHFWVPEV-----TQGVSLMTGMLLltwqKLAP---ISIMIQMFPSINLNILMLIALLSVLTGGWGGL- 172
Cdd:MTH00204 217 LSLAVKIPQIPFHIWLPQAhveapVAGSVILAGILL----KLGGygfLRFSWPLFPAASEYFAPLIVMLSVIAVIYGSLt 292
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 712041735 173 --NQTQLRKILAYSSIAHMGwMMTILMFCPSMTMLNLFIYLML 213
Cdd:MTH00204 293 tcRQVDFKRLIAYSSVAHMG-LVPLGLFTHTIEGLVAAVFLML 334
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
2-193 2.27e-03

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 39.69  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735   2 KPPILMIIMTTIFMGTMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMFTIVFNAMHS 81
Cdd:PRK02546 113 KPKLFYFLMLAMYGGQIAVFAVQDMLLFFLAWELELIPVYLLLAIWGGKKRQYAATKFILYTAGSSLFILLAALAMAFYG 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  82 GQWT--ITNIDSNN------MLISSTMIVALTMKLGMTPFHFWVP----EVTQGVSLMTGMLLLTWQKLAPISIMIQMFP 149
Cdd:PRK02546 193 DTPTfdMTALAAKDfglgfqLLCYAGLLIAYGVKLPIVPLHTWLPdahgEATAPVHMLLAGILLKMGGYALLRMNAGMLP 272
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 712041735 150 SINLNILMLIALLSVLTGGWGGLN---QTQLRKILAYSSIAHMGWMM 193
Cdd:PRK02546 273 DAHAQFAPLLIVLGVVNIIYAALTsfaQRNLKRKIAYSSISHMGFVL 319
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
17-301 5.48e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 38.64  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  17 TMLTMISSHWLLIWIGLEINMLSIIPILAKNPKPRSTEAATKYFLTQATASMLLMF---TIVFNAMHSGQWTITNIDSNN 93
Cdd:PRK06589 129 GVLIALSSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLpavILIYTKTGNLDFVSGGLFSKN 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  94 M-LISSTMIVALTMKLGMTPFHFWVPE-----------------VTQGVSLMTGMLLLTWqKLAPISIMIQMFpsinlNI 155
Cdd:PRK06589 209 QsIILLLMFIYGIAKTAIFPVHSWLPAamvahypvsallhavivVKTGLFCIYKILLYIF-GLSYLQRIFAEF-----NW 282
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 156 LMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGW-MMTILMFCP---SMTMLNLFIYLMLTITMFTMLNMNTNTT--- 228
Cdd:PRK06589 283 LIFIPIVSIFYSSLKALKTDNIKKILAYSTISQLSLaLLSAFILTPkalGAAILHLVSHSFAKICLFYSMGSIYSLKked 362
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 712041735 229 -TLTLSSLWSKSPTITTMILVSLLSLGGLPPLTGFLPKWVIIQELTKNNNIIVATMMAIM----ALLNLYFYMRLIYS 301
Cdd:PRK06589 363 qVDKLHGTSKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMLVviasSILSALYLLKILSS 440
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
100-213 7.13e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 37.98  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 100 MIVALTMKLGMTPFHFWVPEV-----TQGVSLMTGMLL-LTWQKLAPISIMIQMFPSINLN-ILMLIALLSVLTGGWGGL 172
Cdd:MTH00226 236 IFLAMAVKIPIFPFHIWLPKAhveapVAGSVLLAGILLkLGGYGLVRLSWPILPLGAQNLApAVIAMGIVGIVYGSFATC 315
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 712041735 173 NQTQLRKILAYSSIAHMGwMMTILMFCPSMTMLNLFIYLML 213
Cdd:MTH00226 316 RQIDVKRLVAYSSVAHMG-LVSITLVTHDIIGLTGSIFIML 355
ND5 MTH00032
NADH dehydrogenase subunit 5; Provisional
113-196 9.44e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 214407 [Multi-domain]  Cd Length: 669  Bit Score: 38.02  E-value: 9.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735 113 FHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFP-----SINLNILMLIALLSVLTGGWGGLNQTQLRKILAYSSIA 187
Cdd:MTH00032 244 LHTWLPDAMEGPTPVSALIHAATMVTAGVFLMIRSFPlfekaPLTLLIITIFGALTAFFAATVGLVQNDLKKVIAYSTCS 323

                 ....*....
gi 712041735 188 HMGWMMTIL 196
Cdd:MTH00032 324 QLGYMVLII 332
ND5 MTH00207
NADH dehydrogenase subunit 5; Provisional
82-218 9.75e-03

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 164753 [Multi-domain]  Cd Length: 572  Bit Score: 37.82  E-value: 9.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712041735  82 GQWTITNI---DSNNMLISSTMIVALTmKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMIQMFPSIN-----L 153
Cdd:MTH00207 165 GHWSITNMwqtDMNNYIALSIMIAAMT-KSAQMPFSSWLPAAMAAPTPVSALVHSSTLVTAGVFLLIRFYPFLSstywfN 243
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 712041735 154 NILMLIALLSVLTGGWGGLNQTQLRKILAYSSIAHMGWMMTILmfcpSMTMLNLFIYLMLTITMF 218
Cdd:MTH00207 244 PALLLTASLTMLMAGLSAMTECDMKKIIALSTLSQLGVMMASL----GLGMPKLALFHLITHALF 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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