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Conserved domains on  [gi|71061623|gb|AAZ20811|]
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iroquois homeobox protein 5 [Rattus norvegicus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10531334)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 3.20e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 74.86  E-value: 3.20e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71061623   131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 223-411 7.26e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   223 KAAAGCERLQGPLSPAGKETEGSLSDSDfKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAP-GPHP 301
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPaGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   302 SAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRA 377
Cdd:PHA03247 2751 PGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 71061623   378 SPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 3.20e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 74.86  E-value: 3.20e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71061623   131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 116-174 2.12e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 2.12e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 71061623 116 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKEN 174
Cdd:cd00086   4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 115-171 2.29e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.80  E-value: 2.29e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 71061623    115 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLK 171
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 223-411 7.26e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   223 KAAAGCERLQGPLSPAGKETEGSLSDSDfKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAP-GPHP 301
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPaGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   302 SAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRA 377
Cdd:PHA03247 2751 PGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 71061623   378 SPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
112-175 1.83e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.73  E-value: 1.83e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71061623 112 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKENK 175
Cdd:COG5576  51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
328-345 3.78e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.78e-03
                           10
                   ....*....|....*...
gi 71061623    328 AVLAKPKLWSLAEIATSS 345
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 3.20e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 74.86  E-value: 3.20e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71061623   131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 116-174 2.12e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 2.12e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 71061623 116 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKEN 174
Cdd:cd00086   4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 115-171 2.29e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.80  E-value: 2.29e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 71061623    115 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLK 171
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
116-172 2.59e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 44.41  E-value: 2.59e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 71061623   116 RKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKK 172
Cdd:pfam00046   4 RTTFTPEQLEELEK---EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 223-411 7.26e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   223 KAAAGCERLQGPLSPAGKETEGSLSDSDfKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAP-GPHP 301
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPaGPAT 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   302 SAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRA 377
Cdd:PHA03247 2751 PGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 71061623   378 SPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
112-175 1.83e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.73  E-value: 1.83e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71061623 112 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKENK 175
Cdd:COG5576  51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
328-345 3.78e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.78e-03
                           10
                   ....*....|....*...
gi 71061623    328 AVLAKPKLWSLAEIATSS 345
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 265-314 4.16e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.72  E-value: 4.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 71061623  265 RPPRAGEPSPAGPATARLAEDAGPHYPAGAPAPGP-HPSAGELPPGSGGSS 314
Cdd:PRK14965 399 APPPAAAPPVPPAAPARPAAARPAPAPAPPAAAAPpARSADPAAAASAGDR 449
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 244-405 7.25e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 38.71  E-value: 7.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623  244 GSLSDSDFKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAG-PHypagaPAPGPHPSAGELPPGSGGsSVIHSPPPP 322
Cdd:PHA03325 255 GQLTSSAFMLNSSLPTSAPKRRSRRAGAMRAAAGETADLADDDGsEH-----SDPEPLPASLPPPPVRRP-RVKHPEAGK 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623  323 PPPPPAVLAKPKLWSLAEIATSSDKVKDGG----GGSEGSPCPPCPGPIGGQTLGGSRASPAPAPARSPSAQCPFPGGTV 398
Cdd:PHA03325 329 EEPDGARNAEAKEPAQPATSTSSKGSSSAQnkdsGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMPSPSVTSAPEP 408


                 ....*..
gi 71061623  399 LSRPLYY 405
Cdd:PHA03325 409 PSIPLTY 415
PHA03247 PHA03247
large tegument protein UL36; Provisional
 199-400 7.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 7.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   199 DEDEPQKPEDKGDLEGPEAGGTEqkAAAGCERLQGPLSPAGKETegslsdSDFKESPSEGRHDDLPRPPRAGEPSPAGPA 278
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHP--PPTVPPPERPRDDPAPGRV------SRPRRARRLGRAAQASSPPQRPRRRAARPT 2691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71061623   279 TARLAEDAGPHYPAGAPAPGPHP--SAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPklwslaeiatssdkVKDGGggse 356
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHAlvSATPLPPGPAAARQASPALPAAPAPPAVPAGP--------------ATPGG---- 2753

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 71061623   357 gspcpPCPGPIGGQTLGGSRASPAPAPARSPSAQCPFPGGTVLS 400
Cdd:PHA03247 2754 -----PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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