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Conserved domains on  [gi|70778726|ref|NP_067474|]
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WD repeat-containing protein WRAP73 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-436 5.30e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  15 RFSPDGKYLASCVQYRLVIRDVTTLQILQLYTCLDQIQHIEWSADSLFILCAMYRRGLVQVWSLEQPEWHCKIDEGSAGL 94
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  95 VASC-WSPDGRHILnTTEFHLRITVWSLCTKSVSYIKYPKACQ-QGLTFTRDGRYLALAerrdCRDY-VSIFVCSDWQLL 171
Cdd:COG2319  81 VLSVaFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAvRSVAFSPDGKTLASG----SADGtVRLWDLATGKLL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 172 RHFDTDTQDLTGIEWAPNGCVLAAWDTclEYKVLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLL 250
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLW 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 251 NHVTWKMITEF-GHPATINnpkTVVYkeaekSPllgLGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVAD 325
Cdd:COG2319 232 DLATGKLLRTLtGHSGSVR---SVAF-----SP---DGRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 326 RANPrmgvgmLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAG 404
Cdd:COG2319 290 GVNS------VAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       410       420       430
                ....*....|....*....|....*....|..
gi 70778726 405 CVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 436
Cdd:COG2319 362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-436 5.30e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  15 RFSPDGKYLASCVQYRLVIRDVTTLQILQLYTCLDQIQHIEWSADSLFILCAMYRRGLVQVWSLEQPEWHCKIDEGSAGL 94
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  95 VASC-WSPDGRHILnTTEFHLRITVWSLCTKSVSYIKYPKACQ-QGLTFTRDGRYLALAerrdCRDY-VSIFVCSDWQLL 171
Cdd:COG2319  81 VLSVaFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAvRSVAFSPDGKTLASG----SADGtVRLWDLATGKLL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 172 RHFDTDTQDLTGIEWAPNGCVLAAWDTclEYKVLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLL 250
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLW 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 251 NHVTWKMITEF-GHPATINnpkTVVYkeaekSPllgLGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVAD 325
Cdd:COG2319 232 DLATGKLLRTLtGHSGSVR---SVAF-----SP---DGRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 326 RANPrmgvgmLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAG 404
Cdd:COG2319 290 GVNS------VAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       410       420       430
                ....*....|....*....|....*....|..
gi 70778726 405 CVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 436
Cdd:COG2319 362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-401 7.62e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 7.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  89 EGSAGLVAS-CWSPDGRHIL----NTTefhlrITVWSLCTKSVSY-IKYPKACQQGLTFTRDGRYLALAerrdCRDY-VS 161
Cdd:cd00200   6 KGHTGGVTCvAFSPDGKLLAtgsgDGT-----IKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG----SSDKtIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 162 IFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAA---------WDtcLEYKVLLYSLDGRllsaycayewSLGIKSVAWS 232
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSssrdktikvWD--VETGKCLTTLRGH----------TDWVNSVAFS 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 233 PSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRA--MAGALSTSESKYE 309
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWDLRTGKCVATLtGHTGEVN-------------------SVAFSPDGEklLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 310 IASGpVSLQTLKPvadranPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLK-LFVVLEHMSPVRSFQWDPQQPRL 388
Cdd:cd00200 206 LSTG-KCLGTLRG------HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGEcVQTLSGHTNSVTSLAWSPDGKRL 276

                       330
                ....*....|...
gi 70778726 389 AICTGGSKVYLWS 401
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-249 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*
gi 70778726    225 GIKSVAWSPSSQFLAIGSYDGKVRL 249
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKL 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 203-258 2.40e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70778726   203 KVLLYSLDGRLLSAYCAYEWSLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMI 258
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-436 5.30e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 5.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  15 RFSPDGKYLASCVQYRLVIRDVTTLQILQLYTCLDQIQHIEWSADSLFILCAMYRRGLVQVWSLEQPEWHCKIDEGSAGL 94
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  95 VASC-WSPDGRHILnTTEFHLRITVWSLCTKSVSYIKYPKACQ-QGLTFTRDGRYLALAerrdCRDY-VSIFVCSDWQLL 171
Cdd:COG2319  81 VLSVaFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAvRSVAFSPDGKTLASG----SADGtVRLWDLATGKLL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 172 RHFDTDTQDLTGIEWAPNGCVLAAWDTclEYKVLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLL 250
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLW 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 251 NHVTWKMITEF-GHPATINnpkTVVYkeaekSPllgLGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVAD 325
Cdd:COG2319 232 DLATGKLLRTLtGHSGSVR---SVAF-----SP---DGRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSG 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 326 RANPrmgvgmLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAG 404
Cdd:COG2319 290 GVNS------VAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       410       420       430
                ....*....|....*....|....*....|..
gi 70778726 405 CVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 436
Cdd:COG2319 362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
12-404 7.09e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 7.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  12 LLCRFSPDGKYLASCVQYRLVIR--DVTTLQILQLYTCLDQIQHIEWSADSLFILCAMyRRGLVQVWSLEQPEWHCKIDE 89
Cdd:COG2319  40 ASLAASPDGARLAAGAGDLTLLLldAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-ADGTVRLWDLATGLLLRTLTG 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  90 GSAGLVASCWSPDGRHILNTTEFHlRITVWSLCT-KSVSYIKYPKACQQGLTFTRDGRYLALAerrdCRDY-VSIFVCSD 167
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADG-TVRLWDLATgKLLRTLTGHSGAVTSVAFSPDGKLLASG----SDDGtVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 168 WQLLRHFDTDTQDLTGIEWAPNGCVLAA--WDTcleyKVLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYD 244
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASgsADG----TVRLWDLAtGKLLRTLTGHSGS--VRSVAFSPDGRLLASGSAD 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 245 GKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPpramagalstsESKYeIASG-------PVS 316
Cdd:COG2319 268 GTVRLWDLATGELLRTLtGHSGGVN-------------------SVAFSP-----------DGKL-LASGsddgtvrLWD 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 317 LQTLKPVADRANPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGS 395
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSADG 394


                ....*....
gi 70778726 396 KVYLWSPAG 404
Cdd:COG2319 395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
69-437 1.00e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.00e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  69 RRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWSLCTKSVSYIKYPKACQQGLTFTRDGRYL 148
Cdd:COG2319  14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 149 ALAERRDcrdYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAA--WDtcleYKVLLYSL-DGRLLSAYCAYEWslG 225
Cdd:COG2319  94 ASASADG---TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASgsAD----GTVRLWDLaTGKLLRTLTGHSG--A 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 226 IKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPpramagalsts 304
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVR-------------------SVAFSP----------- 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 305 ESKYeIASGPV-------SLQTLKPVADRANPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPV 376
Cdd:COG2319 215 DGKL-LASGSAdgtvrlwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTgHSGGV 291

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 70778726 377 RSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDH 437
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-401 7.62e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 7.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  89 EGSAGLVAS-CWSPDGRHIL----NTTefhlrITVWSLCTKSVSY-IKYPKACQQGLTFTRDGRYLALAerrdCRDY-VS 161
Cdd:cd00200   6 KGHTGGVTCvAFSPDGKLLAtgsgDGT-----IKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASG----SSDKtIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 162 IFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAA---------WDtcLEYKVLLYSLDGRllsaycayewSLGIKSVAWS 232
Cdd:cd00200  77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSssrdktikvWD--VETGKCLTTLRGH----------TDWVNSVAFS 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 233 PSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRA--MAGALSTSESKYE 309
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWDLRTGKCVATLtGHTGEVN-------------------SVAFSPDGEklLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 310 IASGpVSLQTLKPvadranPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLK-LFVVLEHMSPVRSFQWDPQQPRL 388
Cdd:cd00200 206 LSTG-KCLGTLRG------HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGEcVQTLSGHTNSVTSLAWSPDGKRL 276

                       330
                ....*....|...
gi 70778726 389 AICTGGSKVYLWS 401
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-268 1.61e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 1.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  14 CRFSPDGKYLASCVQYRLV-IRDVTTLQIL-QLYTCLDQIQHIEWSADSLFILCAmYRRGLVQVWSLEQPEWHCKIdEGS 91
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIkVWDLETGELLrTLKGHTGPVRDVAASADGTYLASG-SSDKTIRLWDLETGECVRTL-TGH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  92 AGLVASC-WSPDGrHILNTTEFHLRITVWSL----CTKSVSYIKYPKACqqgLTFTRDGRYLALAerrdCRD-YVSIFVC 165
Cdd:cd00200  93 TSYVSSVaFSPDG-RILSSSSRDKTIKVWDVetgkCLTTLRGHTDWVNS---VAFSPDGTFVASS----SQDgTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 166 SDWQLLRHFDTDTQDLTGIEWAPNGCVLAAwdTCLEYKVLLYSLDGRLLSAYCAYEWSlGIKSVAWSPSSQFLAIGSYDG 245
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHEN-GVNSVAFSPDGYLLASGSEDG 241

                       250       260
                ....*....|....*....|....
gi 70778726 246 KVRLLNHVTWKMITEF-GHPATIN 268
Cdd:cd00200 242 TIRVWDLRTGECVQTLsGHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-436 1.79e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 223 SLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRAMAgaL 301
Cdd:cd00200  51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVS-------------------SVAFSPDGRIL--S 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 302 STSESK----YEIASGpVSLQTLKPVADRANprmgvgMLAFSSDSYFLA-SRNDNvpnAVWIWDIQKLKLFVVLE-HMSP 375
Cdd:cd00200 110 SSSRDKtikvWDVETG-KCLTTLRGHTDWVN------SVAFSPDGTFVAsSSQDG---TIKLWDLRTGKCVATLTgHTGE 179

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 70778726 376 VRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 436
Cdd:cd00200 180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 225-436 3.39e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 3.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 225 GIKSVAWSPSSQFLAIGSYDGKVRLlnhvtWKMITEfghpatinnpktvvykeaekSPLLGL-GHLSFpppraMAGALST 303
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKV-----WDLETG--------------------ELLRTLkGHTGP-----VRDVAAS 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 304 SESKYEIASGP------VSLQTLKPVADRANPRMGVGMLAFSSD-SYFLASRNDNVpnaVWIWDIQKLKLFVVLE-HMSP 375
Cdd:cd00200  61 ADGTYLASGSSdktirlWDLETGECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKT---IKVWDVETGKCLTTLRgHTDW 137

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70778726 376 VRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQV-PGEGDfPVLGLCWHLSGDSLALLSKD 436
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTG-EVNSVAFSPDGEKLLSSSSD 198
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 15-121 2.43e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 2.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726  15 RFSPDGKYLA----SCVQYRLVIRDVTTLQILQLYTCLDQIQHIEWSADSLFILCAMYRRGLVQVWSLeqpewhcKIDEG 90
Cdd:COG0823  37 AWSPDGRRIAftsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRSDGRFDIYVL-------DLDGG 109

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 70778726  91 -----SAGLVASCWSPDGRHILNTTEFHLRITVWSL 121
Cdd:COG0823 110 aprrlTDGPGSPSWSPDGRRIVFSSDRGGRPDLYVV 145
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-249 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.44e-03
                           10        20
                   ....*....|....*....|....*
gi 70778726    225 GIKSVAWSPSSQFLAIGSYDGKVRL 249
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKL 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 203-258 2.40e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70778726   203 KVLLYSLDGRLLSAYCAYEWSLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMI 258
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
WD40 pfam00400
WD domain, G-beta repeat;
225-249 4.90e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.90e-03
                          10        20
                  ....*....|....*....|....*
gi 70778726   225 GIKSVAWSPSSQFLAIGSYDGKVRL 249
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 366-451 6.98e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 6.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778726 366 LFVVLEHMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDHFCLCF-LE 444
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdLE 81


                ....*..
gi 70778726 445 TKERVGT 451
Cdd:cd00200  82 TGECVRT 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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