NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|705675009|ref|XP_010116507|]
View 

PREDICTED: kelch-like protein 11, partial [Chlamydotis macqueenii]

Protein Classification

kelch-like protein( domain architecture ID 13335465)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases; similar to kelch-like protein 11, a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation

Gene Ontology:  GO:0005515
PubMed:  10603472

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 18-105 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


:

Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.94  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 705675009  98 ERERYFED 105
Cdd:cd18451   81 ERERYFEE 88
PHA03098 super family cl33709
kelch-like protein; Provisional
 6-375 9.77e-29

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 119.87  E-value: 9.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009   6 LKEFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILF 85
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVL 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  86 ETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVSSNEACLKLVSEAVESHaLRSENLQSGN----- 158
Cdd:PHA03098 173 EIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI-IYSKKYNLNKilprs 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 159 LQHSACPVALLPRFGQNM------------------------------DVIMVIGGVSEGGDYLSECVGYFIDEDRWVNL 208
Cdd:PHA03098 247 STFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKV 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 209 PHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSIGGHGNFSPGFK 287
Cdd:PHA03098 327 PELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLK 406

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 288 DVAIYNPEQDKWLNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQWQDVESLplidNYCSF 367
Cdd:PHA03098 407 TVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNKWTELSSL----NFPRI 479


                 ....*...
gi 705675009 368 QMSVANTN 375
Cdd:PHA03098 480 NASLCIFN 487
Kelch smart00612
Kelch domain;
429-475 2.81e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.81e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 705675009   429 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 475
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 18-105 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.94  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 705675009  98 ERERYFED 105
Cdd:cd18451   81 ERERYFEE 88
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 23-125 1.54e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 117.26  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009   23 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 102
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 705675009  103 FEDLFKLLRLSQMKPTYLTRHVK 125
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
PHA03098 PHA03098
kelch-like protein; Provisional
 6-375 9.77e-29

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 119.87  E-value: 9.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009   6 LKEFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILF 85
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVL 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  86 ETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVSSNEACLKLVSEAVESHaLRSENLQSGN----- 158
Cdd:PHA03098 173 EIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI-IYSKKYNLNKilprs 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 159 LQHSACPVALLPRFGQNM------------------------------DVIMVIGGVSEGGDYLSECVGYFIDEDRWVNL 208
Cdd:PHA03098 247 STFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKV 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 209 PHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSIGGHGNFSPGFK 287
Cdd:PHA03098 327 PELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLK 406

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 288 DVAIYNPEQDKWLNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQWQDVESLplidNYCSF 367
Cdd:PHA03098 407 TVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNKWTELSSL----NFPRI 479


                 ....*...
gi 705675009 368 QMSVANTN 375
Cdd:PHA03098 480 NASLCIFN 487
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 23-123 3.51e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 3.51e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009    23 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 102
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 705675009   103 FEDLFKLLRLSQMKPTYLTRH 123
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
205-475 2.84e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 96.76  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 205 WVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNL-ITRKHSFGLTEVKGNLYSIGGHGNF 282
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 283 SPG---FKDVAIYNPEQDKWLNLESAPKILRDVKAVSVEDRfVYVAArtpvdSDSEDGLRAVIIRYDAETRQWQDVESLP 359
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGK-IYVVG-----GWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 360 lidnycsfqmsvaNTNFYHTASCCPKSypidneeakvKI------SGRASDEILESLPPEVLSIEGAAICYYKDDVFIIG 433
Cdd:COG3055  157 -------------TPRDHLAAAVLPDG----------KIlviggrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 705675009 434 GwknsddiDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 475
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-23 5.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 54.86  E-value: 5.08e-09
                         10        20
                 ....*....|....*....|...
gi 705675009   1 FLLTRLKEFCGEFLKKKLNLSNC 23
Cdd:cd18241  113 FLLIRLKEFCGEFLKKKLNLSNC 135
Kelch smart00612
Kelch domain;
429-475 2.81e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.81e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 705675009   429 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 475
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch smart00612
Kelch domain;
227-271 2.15e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 705675009   227 VYVAGSMEPG-FAKTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 271
Cdd:smart00612   2 IYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 217-257 2.64e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 705675009  217 GHAVAVTESYVYVA-GSMEPGFAKTVERYNPNRNIWEQVSNL 257
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSM 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 419-466 8.73e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 8.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 705675009  419 GAAICYYKDDVFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMP 466
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGN-----QSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 18-105 2.63e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 190.94  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 705675009  98 ERERYFED 105
Cdd:cd18451   81 ERERYFEE 88
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 23-125 1.54e-31

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 117.26  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009   23 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 102
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 705675009  103 FEDLFKLLRLSQMKPTYLTRHVK 125
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
PHA03098 PHA03098
kelch-like protein; Provisional
 6-375 9.77e-29

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 119.87  E-value: 9.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009   6 LKEFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILF 85
Cdd:PHA03098  93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVL 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  86 ETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVSSNEACLKLVSEAVESHaLRSENLQSGN----- 158
Cdd:PHA03098 173 EIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI-IYSKKYNLNKilprs 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 159 LQHSACPVALLPRFGQNM------------------------------DVIMVIGGVSEGGDYLSECVGYFIDEDRWVNL 208
Cdd:PHA03098 247 STFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKV 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 209 PHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSIGGHGNFSPGFK 287
Cdd:PHA03098 327 PELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLK 406

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 288 DVAIYNPEQDKWLNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQWQDVESLplidNYCSF 367
Cdd:PHA03098 407 TVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNKWTELSSL----NFPRI 479


                 ....*...
gi 705675009 368 QMSVANTN 375
Cdd:PHA03098 480 NASLCIFN 487
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 23-123 3.51e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 3.51e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009    23 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 102
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 705675009   103 FEDLFKLLRLSQMKPTYLTRH 123
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 18-152 1.43e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 93.62  E-value: 1.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVSSNEACLKLVSEAVESHaLRSE 152
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH-LRPE 134
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
205-475 2.84e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 96.76  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 205 WVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNL-ITRKHSFGLTEVKGNLYSIGGHGNF 282
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 283 SPG---FKDVAIYNPEQDKWLNLESAPKILRDVKAVSVEDRfVYVAArtpvdSDSEDGLRAVIIRYDAETRQWQDVESLP 359
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGK-IYVVG-----GWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 360 lidnycsfqmsvaNTNFYHTASCCPKSypidneeakvKI------SGRASDEILESLPPEVLSIEGAAICYYKDDVFIIG 433
Cdd:COG3055  157 -------------TPRDHLAAAVLPDG----------KIlviggrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 705675009 434 GwknsddiDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 475
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 18-147 1.00e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 82.39  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVSSNEACLKLVSEAVESH 147
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 21-131 2.14e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 78.04  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18445    4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 705675009 101 RYFEDLFKLLRLSQMKPTYLTRHVKSERLVS 131
Cdd:cd18445   84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 18-124 6.76e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 76.19  E-value: 6.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYLTRHV 124
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 18-117 9.47e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 75.55  E-value: 9.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEItVDSEEILFETVLKWVQKNPE 97
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 705675009  98 ERERYFEDLFKLLRLSQMKP 117
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 18-147 1.02e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 76.64  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVSSNEACLKLVSEAVESH 147
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 21-112 2.40e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 74.26  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPF-HLIRdWLSDSEITVDSEEILFETVLKWVQKNPEER 99
Cdd:cd18448    5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAqHLEK-LISSSDLNVESESQVYEAVMKWVKHDPQHR 83

                         90
                 ....*....|...
gi 705675009 100 ERYFEDLFKLLRL 112
Cdd:cd18448   84 KRHLDDLLSQVRL 96
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 17-120 1.93e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 71.98  E-value: 1.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....
gi 705675009  97 EERERYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFL 104
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 18-115 7.07e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 70.17  E-value: 7.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTL-PFHLIRDWLSDSeITVDSEEILFETVLKWVQKNP 96
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLsPDELIAIISSDS-LNVEKEEDVFEAVMKWVGKDQ 79

                         90
                 ....*....|....*....
gi 705675009  97 EERERYFEDLFKLLRLSQM 115
Cdd:cd18516   80 EERTKALPVLLESIRFRLM 98
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 21-95 1.42e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 68.59  E-value: 1.42e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKN 95
Cdd:cd18508    3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 18-125 1.95e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 69.42  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYLTRHVK 125
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 21-120 2.08e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 68.98  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18468    3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                         90       100
                 ....*....|....*....|
gi 705675009 101 RYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18468   83 QHIAELLAVVRLPFIHPSYL 102
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 18-115 4.32e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 68.26  E-value: 4.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*...
gi 705675009  98 ERERYFEDLFKLLRLSQM 115
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLM 98
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 18-99 2.08e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 65.42  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 705675009  98 ER 99
Cdd:cd18480   81 AR 82
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 18-112 2.23e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 65.98  E-value: 2.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18460   81 HRQHFWPELLQHVRL 95
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 18-106 3.31e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 65.39  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTL-PFHLIrDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLsPCQLV-ALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|
gi 705675009  97 EERERYFEDL 106
Cdd:cd18458   81 ENRRQYLEAL 90
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
177-359 3.41e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.80  E-value: 3.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 177 DVIMVIGGVSeGGDYLSECVGYFIDEDRWVNLPHIHNHLDGHAVAVT-ESYVYVAG-----SMEPGFAKTVERYNPNRNI 250
Cdd:COG3055   23 GKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGgftgaNPSSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 251 WEQVSNLITRKHSFGLTEVKGNLYSIGGHGNfSPGFKDVAIYNPEQDKWLNLESAPKILRDVKAVSVEDRFVYVA--ART 328
Cdd:COG3055  102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVIggRNG 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 705675009 329 PVDSDS----------------------------EDGLRAVIIRYDAETRQWQDVESLP 359
Cdd:COG3055  181 SGFSNTwttlaplptaraghaaavlggkilvfggESGFSDEVEAYDPATNTWTALGELP 239
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 17-94 3.96e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 64.72  E-value: 3.96e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQK 94
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 19-106 7.94e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 64.26  E-value: 7.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  19 NLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEE 98
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80


                 ....*...
gi 705675009  99 RERYFEDL 106
Cdd:cd18455   81 RKVHLKDL 88
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 18-96 9.01e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 63.78  E-value: 9.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQD-EEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 18-115 1.45e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 63.71  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*...
gi 705675009  98 ERERYFEDLFKLLRLSQM 115
Cdd:cd18477   81 NRQKALPTVFESIRFRLL 98
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 18-112 3.98e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 62.66  E-value: 3.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18467   81 ERQKYLAQLLHCVRL 95
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 18-112 5.39e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 62.00  E-value: 5.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 21-96 8.71e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 60.98  E-value: 8.71e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18474    4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
177-293 1.31e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.18  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 177 DVIMVIGGVSEGGDYlsecvgyfideDRWVNLPHIHNHLDGHAVAVTESYVYVAGSmEPGFAKTVERYNPNRNIWEQVSN 256
Cdd:COG3055  170 GKILVIGGRNGSGFS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAYDPATNTWTALGE 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 705675009 257 LITRKHSFGLTEVKGNLYSIGGH---GNFSPGFKDVAIYN 293
Cdd:COG3055  238 LPTPRHGHAAVLTDGKVYVIGGEtkpGVRTPLVTSAEVYD 277
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 19-73 1.57e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 59.21  E-value: 1.57e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 705675009  19 NLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSD 73
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 17-120 3.25e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 60.08  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 705675009  97 EERERYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 18-112 3.32e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 59.87  E-value: 3.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFytlpFHLIRDWL----SDSEITVDSEEILFETVLKWVQ 93
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEF----LHLTKDQLisilNSDDLNVEKEEHVYESIIHWFE 76

                         90       100
                 ....*....|....*....|
gi 705675009  94 KNPEERERYFEDLF-KLLRL 112
Cdd:cd18483   77 HEQSKREMHLPEIFaKCIRM 96
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 16-119 1.35e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 58.23  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  16 KKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKN 95
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|....
gi 705675009  96 PEERERYFEDLFKLLRLSQMKPTY 119
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 17-120 3.10e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 57.23  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 705675009  97 EERERYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 17-112 3.36e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 57.05  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*.
gi 705675009  97 EERERYFEDLFKLLRL 112
Cdd:cd18459   81 QERRPHLPQVLQHVRL 96
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 18-112 1.17e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 55.65  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNpE 97
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18470   80 KRVKYAADLLSNIRF 94
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 18-113 1.77e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 54.85  E-value: 1.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*.
gi 705675009  98 ERERYFEDLFKLLRLS 113
Cdd:cd18514   81 KRKDYLPELLRNVRLA 96
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 18-95 3.10e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 53.51  E-value: 3.10e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKN 95
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 18-120 4.98e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 53.87  E-value: 4.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 705675009  98 ERERYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-23 5.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 54.86  E-value: 5.08e-09
                         10        20
                 ....*....|....*....|...
gi 705675009   1 FLLTRLKEFCGEFLKKKLNLSNC 23
Cdd:cd18241  113 FLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 21-117 5.98e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 53.58  E-value: 5.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18485    4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                         90
                 ....*....|....*..
gi 705675009 101 RYFEDLFKLLRLSQMKP 117
Cdd:cd18485   84 QHLVELLKQVRLELVSP 100
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 18-112 6.83e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 53.47  E-value: 6.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18456   81 GRRQHVPRLMKCVRL 95
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 18-92 6.99e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 52.39  E-value: 6.99e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWV 92
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
179-326 8.52e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.70  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 179 IMVIGGVSEGGDYLSECVgYFIDEDRWV---NLPHIHNHLdgHAVAVTESYVYVAGsmepGFAKTVerynpNRNIWEQVS 255
Cdd:COG3055  124 IYVVGGWDDGGNVAWVEV-YDPATGTWTqlaPLPTPRDHL--AAAVLPDGKILVIG----GRNGSG-----FSNTWTTLA 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 705675009 256 NLITRKHSFGLTEVKGNLYSIGGHGNFspgFKDVAIYNPEQDKWLNLESAPKILRDVKAVSVEDRfVYVAA 326
Cdd:COG3055  192 PLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGK-VYVIG 258
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 18-112 4.83e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 50.89  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90
                 ....*....|....*
gi 705675009  98 ERERYFEDLFKLLRL 112
Cdd:cd18462   81 KRIECAYDLLSSIKL 95
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 21-113 6.40e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 50.36  E-value: 6.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|...
gi 705675009 101 RYFEDLFKLLRLS 113
Cdd:cd18515   83 CYLSELLQTVRLA 95
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 30-92 8.65e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 49.50  E-value: 8.65e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 705675009  30 AHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWV 92
Cdd:cd18493   12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 17-112 1.11e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 50.05  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  17 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*.
gi 705675009  97 EERERYFEDLFKLLRL 112
Cdd:cd18447   81 PNRQPYMVDILAKVRF 96
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 21-113 1.53e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 49.42  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|...
gi 705675009 101 RYFEDLFKLLRLS 113
Cdd:cd18464   83 EVLPELLRSVRLA 95
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 18-106 1.10e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 44.15  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAhmYSLNQLALKAQ--DMIRRNFHKVIQDEEFYTLPF---HLIRDwlSDSEITVDSEEILFETVLKWV 92
Cdd:cd18502    1 LTPENCIGIRSFA--GRMNDSELLQKvdSYIQENIEEVAESKEFLKLPRlqiEVILE--SNQELESINERKLCQLVLEWV 76

                         90
                 ....*....|....
gi 705675009  93 QKNPEERERYFEDL 106
Cdd:cd18502   77 QRSIEEGGLDLDDL 90
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 18-111 1.17e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 44.03  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHK-VIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 705675009  97 EERERYFEDLFKLLR 111
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 18-96 1.66e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 43.57  E-value: 1.66e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNP 96
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79
Kelch smart00612
Kelch domain;
429-475 2.81e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.81e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 705675009   429 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 475
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
PHA02713 PHA02713
hypothetical protein; Provisional
 10-366 3.35e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.54  E-value: 3.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  10 CGEFLKKKLNLSNCVAV-HSLAHMYSLnQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSE-ITVDSEEILFET 87
Cdd:PHA02713 115 CESYIKDYTNHDTCIYMyHRLYEMSHI-PIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIISTNDnVYLYREGYKVTI 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  88 VLKWVQKNpeererYFEDLFKLLRLSQMKPTYLTRhvKSERLVSSNEAcLKLVSEAVEshaLRSENLQSGNL-QHSACPV 166
Cdd:PHA02713 194 LLKWLEYN------YITEEQLLCILSCIDIQNLDK--KSRLLLYSNKT-INMYPSCIQ---FLLDNKQNRNIiPRQLCLV 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 167 ALLPRFGQNMDVIMViggvseggdylsecvgYFIDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSM---EPGFAKtVER 243
Cdd:PHA02713 262 CHDTKYNVCNPCILV----------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYnfnNPSLNK-VYK 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 244 YNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSIGGHgNFSPGFKDVAIYNPEQDKWLNLESAPKILRDVkAVSVEDRFVY 323
Cdd:PHA02713 325 INIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-NGTNVERTIECYTMGDDKWKMLPDMPIALSSY-GMCVLDQYIY 402

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 705675009 324 -------------VAARTPVDSDSEDGLRAVIIRYDAETRQWqdvESLPlidNYCS 366
Cdd:PHA02713 403 iiggrtehidytsVHHMNSIDMEEDTHSSNKVIRYDTVNNIW---ETLP---NFWT 452
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 18-115 4.35e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 42.58  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQD--EEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKN 95
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90       100
                 ....*....|....*....|
gi 705675009  96 PeeRERYFEDLFKLLRLSQM 115
Cdd:cd18471   81 C--RYQYMDELLQYVRFGLM 98
Kelch smart00612
Kelch domain;
227-271 2.15e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 705675009   227 VYVAGSMEPG-FAKTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 271
Cdd:smart00612   2 IYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 217-257 2.64e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 705675009  217 GHAVAVTESYVYVA-GSMEPGFAKTVERYNPNRNIWEQVSNL 257
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 22-101 3.46e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 40.13  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  22 NCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWvQKNPEERER 101
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 22-106 3.61e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 39.49  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  22 NCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSeitVDSEEILFETVLKWVQKNPEEREr 101
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEERE- 80


                 ....*
gi 705675009 102 YFEDL 106
Cdd:cd18481   81 GFSET 85
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 18-115 3.86e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 39.90  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLS-DS----EITVdseeilFETVLKWV 92
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSrDSfcapEVDI------FNAVRRWC 74

                         90       100
                 ....*....|....*....|...
gi 705675009  93 QKNPEERERyFEDLFKLLRLSQM 115
Cdd:cd14822   75 EHNPDSKED-AKEILEAVRLPLM 96
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 21-120 5.19e-04

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 39.38  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  21 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 100
Cdd:cd18466    4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                         90       100
                 ....*....|....*....|
gi 705675009 101 RYFEDLFKLLRLSQMKPTYL 120
Cdd:cd18466   84 KHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 18-101 1.53e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 37.97  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009  18 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLIRDWLSDSEITVDSEEILFETVLKWVQKNPE 97
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                 ....
gi 705675009  98 ERER 101
Cdd:cd18465   81 RRAS 84
PLN02193 PLN02193
nitrile-specifier protein
 218-358 2.79e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 40.32  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705675009 218 HAVAVTESYVYVAGSMEP-GFAKTVERYNPNRNIWEQVSN---LITRKHSFGLTEVKGNLYSIGGHGNFSpgFKDVAIYN 293
Cdd:PLN02193 272 HSMAADEENVYVFGGVSAtARLKTLDSYNIVDKKWFHCSTpgdSFSIRGGAGLEVVQGKVWVVYGFNGCE--VDDVHYYD 349

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 705675009 294 PEQDKWLNLES---APKILRDVKAVSVEDRFVYVAARTPVDSDSEDG---LRAVIIRYDAETRQWQDVESL 358
Cdd:PLN02193 350 PVQDKWTQVETfgvRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGpgqLTDGTFALDTETLQWERLDKF 420
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 260-299 4.88e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 4.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 705675009  260 RKHSFGLTEVKGNLYSIGGHgNFSPGFKDVAIYNPEQDKW 299
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTW 39
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 419-466 8.73e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 8.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 705675009  419 GAAICYYKDDVFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMP 466
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGN-----QSLNSVEVYDPETNTWSKLPSMP 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH