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Conserved domains on  [gi|701323264|ref|XP_009990698|]
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PREDICTED: ciliary neurotrophic factor receptor subunit alpha, partial [Tauraco erythrolophus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 90-186 1.00e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  90 PDPPESVVAKPVpnNPRRLEVSWQNPsswPDPESFPLKFFLRYRPLILDQWQHVE--LSDGTSHTITDAYAGKEYIIQVA 167
Cdd:cd00063    1 PSPPTNLRVTDV--TSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 701323264 168 AKdNDIGtWSDWSVAVHAT 186
Cdd:cd00063   76 AV-NGGG-ESPPSESVTVT 92
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 90-186 1.00e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  90 PDPPESVVAKPVpnNPRRLEVSWQNPsswPDPESFPLKFFLRYRPLILDQWQHVE--LSDGTSHTITDAYAGKEYIIQVA 167
Cdd:cd00063    1 PSPPTNLRVTDV--TSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 701323264 168 AKdNDIGtWSDWSVAVHAT 186
Cdd:cd00063   76 AV-NGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 90-174 2.78e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 2.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264    90 PDPPESVVAKPVpnNPRRLEVSWQNPSSwPDPESFPLKFFLRYRPLILDQWQHVELSDGTSHTITDAYAGKEYIIQVAAK 169
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPD-DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 701323264   170 dNDIG 174
Cdd:smart00060  78 -NGAG 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
62-192 6.09e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 6.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  62 KYKVTLTVTNALGKSSTTLTFD-EFAIVKPDPPESVVAKPVpnNPRRLEVSWQnPSSWPDPESFPLKfflrYRPLILDQW 140
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLTATAD--TPGSVTLSWD-PVTESDATGYRVY----RSNSGDGPF 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 701323264 141 QHVELSDGTSHTITDAYAGKEYIIQVAAKDNDiGTWSDWSVAVHATPWTEEP 192
Cdd:COG3401  277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA-GNESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
91-180 1.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.40  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264   91 DPPESVVAKPVpnNPRRLEVSWQNPSSWPDPesfPLKFFLRYRPLI-LDQWQHVELSDGT-SHTITDAYAGKEYIIQVAA 168
Cdd:pfam00041   1 SAPSNLTVTDV--TSTSLTVSWTPPPDGNGP---ITGYEVEYRPKNsGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|..
gi 701323264  169 KDNdiGTWSDWS 180
Cdd:pfam00041  76 VNG--GGEGPPS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 90-186 1.00e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  90 PDPPESVVAKPVpnNPRRLEVSWQNPsswPDPESFPLKFFLRYRPLILDQWQHVE--LSDGTSHTITDAYAGKEYIIQVA 167
Cdd:cd00063    1 PSPPTNLRVTDV--TSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 701323264 168 AKdNDIGtWSDWSVAVHAT 186
Cdd:cd00063   76 AV-NGGG-ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 90-174 2.78e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 2.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264    90 PDPPESVVAKPVpnNPRRLEVSWQNPSSwPDPESFPLKFFLRYRPLILDQWQHVELSDGTSHTITDAYAGKEYIIQVAAK 169
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPD-DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 701323264   170 dNDIG 174
Cdd:smart00060  78 -NGAG 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
62-192 6.09e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 6.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  62 KYKVTLTVTNALGKSSTTLTFD-EFAIVKPDPPESVVAKPVpnNPRRLEVSWQnPSSWPDPESFPLKfflrYRPLILDQW 140
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLTATAD--TPGSVTLSWD-PVTESDATGYRVY----RSNSGDGPF 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 701323264 141 QHVELSDGTSHTITDAYAGKEYIIQVAAKDNDiGTWSDWSVAVHATPWTEEP 192
Cdd:COG3401  277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA-GNESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
91-180 1.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.40  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264   91 DPPESVVAKPVpnNPRRLEVSWQNPSSWPDPesfPLKFFLRYRPLI-LDQWQHVELSDGT-SHTITDAYAGKEYIIQVAA 168
Cdd:pfam00041   1 SAPSNLTVTDV--TSTSLTVSWTPPPDGNGP---ITGYEVEYRPKNsGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|..
gi 701323264  169 KDNdiGTWSDWS 180
Cdd:pfam00041  76 VNG--GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
87-189 1.40e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  87 IVKPDPPESVVAkpVPNNPRRLEVSWQNPSSwpdpesFPLKFFLRYR-PLILDQWQHV-ELSDGTSHTITDAYAGKEYII 164
Cdd:COG3401  324 LTPPAAPSGLTA--TAVGSSSITLSWTASSD------ADVTGYNVYRsTSGGGTYTKIaETVTTTSYTDTGLTPGTTYYY 395

                         90       100
                 ....*....|....*....|....*
gi 701323264 165 QVAAKDNDiGTWSDWSVAVHATPWT 189
Cdd:COG3401  396 KVTAVDAA-GNESAPSEEVSATTAS 419
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
63-204 9.89e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 36.46  E-value: 9.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701323264  63 YKVTLTVTNALGKSS-------TTLTFDefaIVKPDPPESVVAKPvpnNPRRLEVSWQNPsswPDPESfpLKFFLRYRPl 135
Cdd:COG4733  599 YEVRVRAINALGVSSawaasseTTVTGK---TAPPPAPTGLTATG---GLGGITLSWSFP---VDADT--LRTEIRYST- 666

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 701323264 136 iLDQWQHVELSD----GTSHTITDAYAGKEYIIQVAAKDnDIGTWSDWSVAVHATPWTEEPKHLTTEAQVTGK 204
Cdd:COG4733  667 -TGDWASATVAQalypGNTYTLAGLKAGQTYYYRARAVD-RSGNVSAWWVSGQASADAAGILDAITGQILETE 737
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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