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Conserved domains on  [gi|700341658|ref|XP_009914645|]
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PREDICTED: IQ domain-containing protein H, partial [Haliaeetus albicilla]

Protein Classification

IQ calmodulin-binding motif-containing protein( domain architecture ID 10635649)

IQ calmodulin-binding motif-containing protein

Gene Ontology:  GO:0005516
PubMed:  9141499

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 222-241 1.08e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|
gi 700341658   222 EMAATKIQATWRCYQARKTY 241
Cdd:smart00015   3 TRAAIIIQAAWRGYLARKRY 22
 
Name Accession Description Interval E-value
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 222-241 1.08e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|
gi 700341658   222 EMAATKIQATWRCYQARKTY 241
Cdd:smart00015   3 TRAAIIIQAAWRGYLARKRY 22
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 222-241 2.16e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 36.14  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|
gi 700341658  222 EMAATKIQATWRCYQARKTY 241
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRY 20
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 224-239 2.54e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 36.37  E-value: 2.54e-03
                         10
                 ....*....|....*.
gi 700341658 224 AATKIQATWRCYQARK 239
Cdd:cd23767   11 AATLIQALWRGYKVRK 26
 
Name Accession Description Interval E-value
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 222-241 1.08e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|
gi 700341658   222 EMAATKIQATWRCYQARKTY 241
Cdd:smart00015   3 TRAAIIIQAAWRGYLARKRY 22
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 222-241 2.16e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 36.14  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|
gi 700341658  222 EMAATKIQATWRCYQARKTY 241
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRY 20
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 224-239 2.54e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 36.37  E-value: 2.54e-03
                         10
                 ....*....|....*.
gi 700341658 224 AATKIQATWRCYQARK 239
Cdd:cd23767   11 AATLIQALWRGYKVRK 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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