NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|699607312|ref|XP_009872268|]
View 

PREDICTED: protein phosphatase 1 regulatory subunit 42 [Apaloderma vittatum]

Protein Classification

protein phosphatase 1 regulatory subunit 42( domain architecture ID 15347297)

protein phosphatase 1 regulatory subunit 42 (PPP1R42) regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 3.09e-118

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


:

Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 339.07  E-value: 3.09e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  27 LQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNCISCIENLSSLKNLEKLYLGGNCI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 107 TVLEGLDKIDQIRELHIESQHLPLGEKLIFDPRSLRSLAKSLSVLNISNNNIDDLEELAVLENLSYLRAVDNQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 187 EVVLNKWTKLRRMDLAGNPICRKPKYRDGIIVQSQTLESLDGKEIKEVERRFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 3.09e-118

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 339.07  E-value: 3.09e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  27 LQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNCISCIENLSSLKNLEKLYLGGNCI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 107 TVLEGLDKIDQIRELHIESQHLPLGEKLIFDPRSLRSLAKSLSVLNISNNNIDDLEELAVLENLSYLRAVDNQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 187 EVVLNKWTKLRRMDLAGNPICRKPKYRDGIIVQSQTLESLDGKEIKEVERRFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-206 1.83e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 1.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  25 QYLQKITHLNLSDKNIDTIGD-FSMCKNLKVLYLYDNQISQIQN-LDFASNITHLYLQNNCISCI-ENLSSLKNLEKLYL 101
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 102 GGNCITVL-EGLDKIDQIRELHIESQHLplgEKLifdPRSLRSLaKSLSVLNISNNNIDDLEELAVLENLSYLRAVDNQL 180
Cdd:COG4886  190 SNNQITDLpEPLGNLTNLEELDLSGNQL---TDL---PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262

                        170       180
                 ....*....|....*....|....*.
gi 699607312 181 QHMKDLEvvlnKWTKLRRMDLAGNPI 206
Cdd:COG4886  263 TDLPPLA----NLTNLKTLDLSNNQL 284
LRR_9 pfam14580
Leucine-rich repeat;
1-107 7.16e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.52  E-value: 7.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312    1 MVRLTMDLIVKSISHKN---RNE-----------EDFGQYLQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQI- 65
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNpvrEREldlrgykipiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIg 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 699607312   66 QNLD-FASNITHLYLQNNCI---SCIENLSSLKNLEKLYLGGNCIT 107
Cdd:pfam14580  81 EGLGeALPNLTELILTNNNLqelGDLDPLASLKKLTFLSLLRNPVT 126
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-246 3.09e-118

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 339.07  E-value: 3.09e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  27 LQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNCISCIENLSSLKNLEKLYLGGNCI 106
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 107 TVLEGLDKIDQIRELHIESQHLPLGEKLIFDPRSLRSLAKSLSVLNISNNNIDDLEELAVLENLSYLRAVDNQLQHMKDL 186
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 187 EVVLNKWTKLRRMDLAGNPICRKPKYRDGIIVQSQTLESLDGKEIKEVERRFLMNWKASK 246
Cdd:cd21340  161 LDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-206 1.83e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 1.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  25 QYLQKITHLNLSDKNIDTIGD-FSMCKNLKVLYLYDNQISQIQN-LDFASNITHLYLQNNCISCI-ENLSSLKNLEKLYL 101
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 102 GGNCITVL-EGLDKIDQIRELHIESQHLplgEKLifdPRSLRSLaKSLSVLNISNNNIDDLEELAVLENLSYLRAVDNQL 180
Cdd:COG4886  190 SNNQITDLpEPLGNLTNLEELDLSGNQL---TDL---PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262

                        170       180
                 ....*....|....*....|....*.
gi 699607312 181 QHMKDLEvvlnKWTKLRRMDLAGNPI 206
Cdd:COG4886  263 TDLPPLA----NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
25-211 1.29e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  25 QYLQKITHLNLSDKNidtigDFSMCKNLKVLYLYDNQISQI-QNLDFASNITHLYLQNNCISCI-ENLSSLKNLEKLYLG 102
Cdd:COG4886   93 GDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 103 GNCITVL-EGLDKIDQIRELHIESQHLplgEKLifdPRSLRSLaKSLSVLNISNNNIDDL-EELAVLENLSYLRAVDNQL 180
Cdd:COG4886  168 NNQLTDLpEELGNLTNLKELDLSNNQI---TDL---PEPLGNL-TNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 699607312 181 QHMKDLEvvlnKWTKLRRMDLAGNPICRKPK 211
Cdd:COG4886  241 TDLPELG----NLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-170 9.13e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 9.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  27 LQKITHLNLSDKNIDTIGD-FSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNCISCIENLSSLKNLEKLYLGGNC 105
Cdd:COG4886  204 LTNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 699607312 106 ITVLEgLDKIDQIRELHIESQHLPLGEKLIFDPRSLRSLAKSLSVLNISNNNIDDLEELAVLENL 170
Cdd:COG4886  284 LTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-206 3.91e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 3.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312   1 MVRLTMDLIVKSISHKNRNEEDFGQYLQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQ 80
Cdd:COG4886   25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  81 NNcisciENLSSLKNLEKLYLGGNCITVL-EGLDKIDQIRELHIESQhlplgeKLIFDPRSLRSLaKSLSVLNISNNNID 159
Cdd:COG4886  105 GN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNN------QLTDLPEPLGNL-TNLKSLDLSNNQLT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 699607312 160 DL-EELAVLENLSYLRAVDNQLQhmkDLEVVLNKWTKLRRMDLAGNPI 206
Cdd:COG4886  173 DLpEELGNLTNLKELDLSNNQIT---DLPEPLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-206 5.42e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312   4 LTMDLIVKSISHKNRNEEDFGQYLQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNC 83
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  84 ISCIENLSSLKNLEKLYLGGNcitvlEGLDKIDQIRELHIESQHLplgEKLifdPRSLRSLaKSLSVLNISNNNIDDL-E 162
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQL---TDL---PEELANL-TNLKELDLSNNQLTDLpE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 699607312 163 ELAVLENLSYLRAVDNQLqhmKDLEVVLNKWTKLRRMDLAGNPI 206
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQL---TDLPEELGNLTNLKELDLSNNQI 194
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 31-227 8.61e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 8.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  31 THLNLSDKNIDTIGDFsmcknLKVLylydnqisqIQNLDFASNITHLYLQNNCISC-----IENLSSLKNLEKLYLGGNC 105
Cdd:cd00116   54 KELCLSLNETGRIPRG-----LQSL---------LQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 106 ITVLEGLDKIDQIRELHIESQHLPLGEKLIFDpRSLRSLAK------SLSVLNISNNNIDD------LEELAVLENLSYL 173
Cdd:cd00116  120 LGDRGLRLLAKGLKDLPPALEKLVLGRNRLEG-ASCEALAKalranrDLKELNLANNGIGDagiralAEGLKANCNLEVL 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 699607312 174 RAVDNQLQH--MKDLEVVLNKWTKLRRMDLAGNPICRKP--KYRDGIIVQSQTLESLD 227
Cdd:cd00116  199 DLNNNGLTDegASALAETLASLKSLEVLNLGDNNLTDAGaaALASALLSPNISLLTLS 256
LRR_9 pfam14580
Leucine-rich repeat;
1-107 7.16e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.52  E-value: 7.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312    1 MVRLTMDLIVKSISHKN---RNE-----------EDFGQYLQKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDNQISQI- 65
Cdd:pfam14580   1 MVKLTAELIEQSAQYTNpvrEREldlrgykipiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIg 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 699607312   66 QNLD-FASNITHLYLQNNCI---SCIENLSSLKNLEKLYLGGNCIT 107
Cdd:pfam14580  81 EGLGeALPNLTELILTNNNLqelGDLDPLASLKKLTFLSLLRNPVT 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 73-104 5.33e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 5.33e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 699607312   73 NITHLYLQNNCISCIENLSSLKNLEKLYLGGN 104
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-206 7.23e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  34 NLSDKNIDTIGDFSMCKNLKVLYLYDNQISQIQNLDFASNITHLYLQNNCISCIENLSSLKNLEKLYLGGNCITVLEGLD 113
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 114 KIDQIRELHIESQHLPLGEKLIFDPRSLRSLAKSLSVLNISNNNIDDL-EELAVLENLSYLRAVDNQLqhmKDLEVVLNK 192
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQL---TDLPEPLGN 157

                        170
                 ....*....|....
gi 699607312 193 WTKLRRMDLAGNPI 206
Cdd:COG4886  158 LTNLKSLDLSNNQL 171
LRR_9 pfam14580
Leucine-rich repeat;
144-259 8.76e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  144 LAKSLSVLNISNNNI----DDLEElaVLENLSYLRAVDNQLQHMKDLEVvLNKWTKLRRMDLAGNPICRKPKYRDGIIVQ 219
Cdd:pfam14580  62 LLRRLKTLLLNNNRIcrigEGLGE--ALPNLTELILTNNNLQELGDLDP-LASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 699607312  220 SQTLESLDGKEIKEVERRflmnwKASKAARKKNKERMTNE 259
Cdd:pfam14580 139 VPQLRLLDFRKVKQKERQ-----AAEKMFRSKQGKQLAKE 173
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 47-206 3.84e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  47 SMCKNLKVLYLYDNQISQ------IQNLDFASNITHLYLQNNCISC------IENLSSLKNLEKLYLGGNcitvlegldk 114
Cdd:COG5238  233 KGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVN---------- 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 115 idqirelhiesqhlPLGEklifdpRSLRSLAKSL------SVLNISNNNIDDLEELAVLENLSYLRAV------DNQL-- 180
Cdd:COG5238  303 --------------RIGD------EGAIALAEGLqgnktlHTLNLAYNGIGAQGAIALAKALQENTTLhsldlsDNQIgd 362

                        170       180
                 ....*....|....*....|....*.
gi 699607312 181 QHMKDLEVVLNKWTKLRRMDLAGNPI 206
Cdd:COG5238  363 EGAIALAKYLEGNTTLRELNLGKNNI 388
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 50-92 6.55e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 6.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 699607312   50 KNLKVLYLYDNQISQIQNLDFASNITHLYL-QNNCISCIENLSS 92
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 28-69 1.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 699607312   28 QKITHLNLSDKNIDTIGDFSMCKNLKVLYLYDN-QISQIQNLD 69
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-204 2.02e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312  40 IDTIGDFSMCKNLKVLYLYDNQISQ--IQNL--DFASN--ITHLYLQNNCISCI------ENLSSLKNLEKLYLGGNCIT 107
Cdd:cd00116  155 EALAKALRANRDLKELNLANNGIGDagIRALaeGLKANcnLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLT 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699607312 108 vLEGldkidqIRELHiesqhlplgeklifdpRSLRSLAKSLSVLNISNNNIDDLEELAVLEnlsylravdnqlqhmkdle 187
Cdd:cd00116  235 -DAG------AAALA----------------SALLSPNISLLTLSLSCNDITDDGAKDLAE------------------- 272

                        170
                 ....*....|....*..
gi 699607312 188 vVLNKWTKLRRMDLAGN 204
Cdd:cd00116  273 -VLAEKESLLELDLRGN 288
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 29-94 3.40e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 3.40e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 699607312   29 KITHLNLSDkNIDTIGD--FSMCKNLKVLYLYDNqISQIQNLDFA-SNITHLYLQNNCIS----CIENLSSLK 94
Cdd:pfam13306  57 SLTSITIPS-SLTSIGEyaFSNCSNLKSITLPSN-LTSIGSYAFSnCSLKSITIPSSVTTigsyAFSNCSNLK 127
LRR_8 pfam13855
Leucine rich repeat;
28-82 4.80e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 4.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 699607312   28 QKITHLNLSDKNIDTIGD--FSMCKNLKVLYLYDNQISQIQNLDFA--SNITHLYLQNN 82
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH