NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|699062791|gb|KGM46306|]
View 

hypothetical protein NP83_00965 [Neobacillus niacini]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-243 5.80e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.80e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   9 NSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQR 88
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  89 LTSFSEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEFdET 168
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL-ET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791 169 TSLYETLKSK-GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQYRVTL 243
Cdd:COG2188  160 GSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-243 5.80e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.80e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   9 NSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQR 88
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  89 LTSFSEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEFdET 168
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL-ET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791 169 TSLYETLKSK-GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQYRVTL 243
Cdd:COG2188  160 GSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
PRK09764 PRK09764
GntR family transcriptional regulator;
13-239 1.53e-29

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 111.07  E-value: 1.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  13 PLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQRLTSF 92
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  93 SEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKS--SDFSLDRTEfdetTS 170
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLAlfPDLTWQVME----NS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791 171 LYETLKS-KGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQY 239
Cdd:PRK09764 161 KYHFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 99-238 4.71e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 104.30  E-value: 4.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791    99 LGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIkkSSDFSLDRTEFDETTSLYETL--- 175
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYL--PAALFPGLLEEDLSGSLYEYLeer 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 699062791   176 -KSKGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQ 238
Cdd:smart00866  80 lGLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 99-238 5.36e-28

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 104.22  E-value: 5.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   99 LGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEFdETTSLYETLKSK 178
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDL-EEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791  179 -GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQ 238
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 17-240 1.23e-26

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 103.21  E-value: 1.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   17 QIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQ-KYDLQRLTSFSED 95
Cdd:TIGR02404   4 QIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQiEFPISGITSFKEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   96 VKKLGEISSSIIRDF-KVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEfdETTSLYET 174
Cdd:TIGR02404  84 NETLGLDSKTEVVELdKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEI--AEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 699062791  175 L-KSKGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQYR 240
Cdd:TIGR02404 162 LeNELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFV 228
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-78 2.62e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 92.13  E-value: 2.62e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791  13 PLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVC 78
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-243 5.80e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.80e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   9 NSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQR 88
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  89 LTSFSEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEFdET 168
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDL-ET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791 169 TSLYETLKSK-GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQYRVTL 243
Cdd:COG2188  160 GSLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
PRK09764 PRK09764
GntR family transcriptional regulator;
13-239 1.53e-29

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 111.07  E-value: 1.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  13 PLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQRLTSF 92
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  93 SEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKS--SDFSLDRTEfdetTS 170
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLAlfPDLTWQVME----NS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791 171 LYETLKS-KGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQY 239
Cdd:PRK09764 161 KYHFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 99-238 4.71e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 104.30  E-value: 4.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791    99 LGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIkkSSDFSLDRTEFDETTSLYETL--- 175
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYL--PAALFPGLLEEDLSGSLYEYLeer 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 699062791   176 -KSKGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQ 238
Cdd:smart00866  80 lGLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 99-238 5.36e-28

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 104.22  E-value: 5.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   99 LGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEFdETTSLYETLKSK 178
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDL-EEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791  179 -GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQ 238
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 17-240 1.23e-26

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 103.21  E-value: 1.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   17 QIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQ-KYDLQRLTSFSED 95
Cdd:TIGR02404   4 QIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQiEFPISGITSFKEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   96 VKKLGEISSSIIRDF-KVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDRTEfdETTSLYET 174
Cdd:TIGR02404  84 NETLGLDSKTEVVELdKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEI--AEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 699062791  175 L-KSKGIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQYR 240
Cdd:TIGR02404 162 LeNELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFV 228
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 6-241 3.67e-25

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 99.47  E-value: 3.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791    6 IDKNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYD 85
Cdd:TIGR02325   1 IERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   86 LQRLTSFSEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYikkssdFSLDR--- 162
Cdd:TIGR02325  81 LSARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTW------FPAARfpg 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  163 --TEFDETTSLYETLKSKGIK-LKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDIYQY 239
Cdd:TIGR02325 155 igQAYAASGSITDALREQGVAdYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEF 234


                  ..
gi 699062791  240 RV 241
Cdd:TIGR02325 235 TM 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-78 2.62e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 92.13  E-value: 2.62e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791  13 PLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVC 78
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
5-249 4.21e-24

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 96.83  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   5 KIDKNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKY 84
Cdd:PRK11402   1 ATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  85 DLQRLTSFSEDVKKLGEISSSIIRDFKVIKADSkTAKSLGIAEGDDVYYLERSRLSGDKIVGLHKAYIKKSSDFSLDrTE 164
Cdd:PRK11402  81 ALLTVSGFTDFGVSQGKATKEKVIEQERVSAAP-FCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD-EI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791 165 FDETTSLYETLKSK-GIKLKHANEILEAQIPDKEIQKSLGISDNIPIFFKERVTFNTAGLPIEFVKMYYRSDiyqyRVTL 243
Cdd:PRK11402 159 YVEGSSTYQLFQERfDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRAN----RVTL 234


                 ....*.
gi 699062791 244 DVSDEN 249
Cdd:PRK11402 235 TIDNKR 240
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
5-99 1.42e-20

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 83.69  E-value: 1.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   5 KIDKNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCA-NKQK 83
Cdd:COG1725    2 RIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdAREL 81

                         90
                 ....*....|....*.
gi 699062791  84 YDLQRLTSFSEDVKKL 99
Cdd:COG1725   82 LEERREEFLEEALREL 97
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
10-80 1.51e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 78.82  E-value: 1.51e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791  10 SKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCAN 80
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREP 74
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 5-80 2.17e-15

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 74.87  E-value: 2.17e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 699062791   5 KIDKNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCAN 80
Cdd:COG1167    4 RLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-77 3.04e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 67.99  E-value: 3.04e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791    18 IYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-77 8.07e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 8.07e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791   17 QIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:pfam00392   4 QVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 10-138 1.29e-14

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 70.96  E-value: 1.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  10 SKVPLHYQ-IYEDIKGEIESKVLQA---GDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYD 85
Cdd:PRK10079   4 SRHPTSYPtRYQEIAAKLEQELRQHyrcGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYP 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 699062791  86 LQRLTSFSEDVKKLGEISSSiIRDFKVIK-ADSKTAKSLGIAEGDDVYYLERSR 138
Cdd:PRK10079  84 LNAQARFSQNLLDQGSHPTS-EKLLSVLRpASGHVADALGITEGENVIHLRTLR 136
PRK14999 PRK14999
histidine utilization repressor; Provisional
 8-133 3.24e-11

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 61.49  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791   8 KNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKYDLQ 87
Cdd:PRK14999   7 RSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 699062791  88 RLTSFSEDVKKLGEISSSIIRDFKVIKADSKTAKSLGIAEGDDVYY 133
Cdd:PRK14999  87 EVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFH 132
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-77 4.12e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 60.71  E-value: 4.12e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 699062791   1 MKQSKIDKnsKVPLHYQIYEDIKGEIESKVLQAGDMLpSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:COG1802    1 MTSPSPLR--RESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK11523 PRK11523
transcriptional regulator ExuR;
14-84 3.91e-09

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 55.62  E-value: 3.91e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791  14 LHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCANKQKY 84
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRH 79
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
22-80 9.21e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 54.64  E-value: 9.21e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 699062791  22 IKGEIESKV----LQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIVCAN 80
Cdd:PRK09464  15 IEQQLEFLIlegtLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 14-72 3.63e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 52.72  E-value: 3.63e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 699062791  14 LHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQG 72
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 17-77 1.43e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 48.22  E-value: 1.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791  17 QIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 7-77 7.60e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 39.75  E-value: 7.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 699062791   7 DKNSKVPLHYQIYEDIKGEIESKVLQAGDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:PRK09990   1 MKDERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK10225 PRK10225
Uxu operon transcriptional regulator;
19-77 1.75e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 38.85  E-value: 1.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 699062791  19 YEDIKGEIESKVLQA----GDMLPSESDLQNLYDVSRITVRRAIQDLENDGFVKKSQGKGTIV 77
Cdd:PRK10225  11 YQEVGAMIRDLIIKTpynpGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
39-72 3.91e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 34.51  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 699062791    39 SESDLQNLYDVSRITVRRAIQDLENDGFVKKSQG 72
Cdd:smart00420  16 SVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 25-78 8.18e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.50  E-value: 8.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 699062791  25 EIESKVLQA-----GDMLpsESDLQNLYDVSRITVRRAIQDLENDGFVKK-SQGKGTIVC 78
Cdd:COG2512   15 EDERRVLELlrengGRMT--QSEIVKETGWSKSKVSRLLSRLEERGLIEKeRVGRENVVE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH