|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-462 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 713.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 1 MPPAIggPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILV 80
Cdd:TIGR00892 1 MPPAL--PPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 81 NKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLST 160
Cdd:TIGR00892 79 NRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLST 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 161 LAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQgKVEKLKSKESLQEAGKsdantdliggSPKGEKLSVFQ 240
Cdd:TIGR00892 159 LAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQ-RVSKSKSKEGLPPDGS----------TKKLSKKSTAE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 241 TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRP 320
Cdd:TIGR00892 228 KINRFLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRP 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 321 RVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPP 400
Cdd:TIGR00892 308 HVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPP 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981542 401 LLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEE------KKRDGKEDETSTD 462
Cdd:TIGR00892 388 LAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAALeregarDKKDAEGDSRESE 455
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-434 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 660.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPIGPQqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnKFLDLSLFTHRGFLL 258
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK------------------------------------------PFLDLTLFTHRGFLL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHL 338
Cdd:cd17426 199 YLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17426 279 LAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWA 358
|
410
....*....|....*.
gi 6981542 419 CGVILIIAGLYLFIGM 434
Cdd:cd17426 359 CGIVLIISSIYLFIGM 374
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-433 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 528.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPIGPqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP-------------------------------------------------LFKHRGFLI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHL 338
Cdd:cd17427 192 YLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17427 272 LCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFV 351
|
410
....*....|....*
gi 6981542 419 CGVILIIAGLYLFIG 433
Cdd:cd17427 352 CGAIVIVASIWLFIG 366
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
19-433 |
2.71e-126 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 372.52 E-value: 2.71e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfLDLSLFTHRGFLL 258
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP------------------------------------------------LDFSVFRDRGFVI 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHL 338
Cdd:cd17430 193 YTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17430 273 CSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYL 352
|
410
....*....|....*
gi 6981542 419 CGVILIIAGLYLFIG 433
Cdd:cd17430 353 AGSEVVLSALFLALG 367
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-432 |
2.25e-111 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 333.75 E-value: 2.25e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-----------------------------------------------------LLKDPTFVL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIrpRVQYFFAASVVANGVCHL 338
Cdd:cd17352 188 LALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--GRLYLYIFTLLILGLSLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17352 266 AFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
|
410
....*....|....
gi 6981542 419 CGVILIIAGLYLFI 432
Cdd:cd17352 346 CGACLLLSGVLLFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-430 |
1.09e-83 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 262.79 E-value: 1.09e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP----------------------------------------------------FCSNTRYQI 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHL 338
Cdd:cd17425 189 YTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17425 269 ICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYA 348
|
410
....*....|..
gi 6981542 419 CGVILIIAGLYL 430
Cdd:cd17425 349 SSIFVVSAALFM 360
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-430 |
3.75e-67 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 220.73 E-value: 3.75e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQeagksdantdliggspkgeklsvfqtvnkflDLSLFTHRGFLL 258
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAF-------------------------------GLSLLTHRAFLR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPrvQYFFAASVVANGVCHL 338
Cdd:cd17423 210 YALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17423 288 LLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLV 367
|
410
....*....|..
gi 6981542 419 CGVILIIAGLYL 430
Cdd:cd17423 368 AGSFLLLGSLIL 379
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-430 |
9.83e-56 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 189.96 E-value: 9.83e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17422 161 LVVGALQLNIVVCGALLR-----------------------------------------------------VLKEPGFIC 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPrvQYFFAASVVANGVCHL 338
Cdd:cd17422 188 YALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRK--IYIELICVILLCVVLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTY 416
Cdd:cd17422 266 LFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAF 345
|
410
....*....|....
gi 6981542 417 WACGVILIIAGLYL 430
Cdd:cd17422 346 YSCAAGMALGAVFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-431 |
4.58e-48 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 169.61 E-value: 4.58e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkFLDLSlfthrGFLL 258
Cdd:cd17424 161 LILGGFVLNLCVCGALMR------------------------------------------------FLLMP-----DFLV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHL 338
Cdd:cd17424 188 LAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd17424 268 FLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLL 347
|
410
....*....|...
gi 6981542 419 CGVILIIAGLYLF 431
Cdd:cd17424 348 SGFSMIFSSLLLG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
19-386 |
1.57e-33 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 130.33 E-value: 1.57e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLStLAPLNQAFFGIFGWRGSF 178
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPIgpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkflDLSLFTHRGFLL 258
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI------------------------------------------------DFSLLKDPFFCI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPrvQYFFAASVVANGVCHL 338
Cdd:cd17421 192 YTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIKK--YHYHKAYLILCGVTNL 269
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGL 386
Cdd:cd17421 270 LAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGF 317
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
19-432 |
1.24e-29 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 119.94 E-value: 1.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSA-----TTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGG 93
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 94 CLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFG 173
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 174 WRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEagksdantdliggspkgeklSVFQTVNKFLDLSLFTH 253
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHS--------------------RINLFLRKIFNVEIFKR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 254 RGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVqYFFAASVVAN 333
Cdd:cd17420 221 KRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 334 GVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK 413
Cdd:cd17420 300 GLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYT 379
|
410
....*....|....*....
gi 6981542 414 YTYWACGVILIIAGLYLFI 432
Cdd:cd17420 380 VAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-431 |
3.81e-28 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 115.45 E-value: 3.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLA-FNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGS 177
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 178 FLILGGLLLNCCVAGSLMRpigpqqgkvekLKSKESLQEAGKSDANTDLIGGSPKGeklsvfqtvnkfldlsLFTHRGFL 257
Cdd:cd17355 161 LLVLALLALLVLVPVLLLL-----------RRRPADLALRAYDDASPASPGSTLKE----------------ALRSASFW 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 258 LYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVAngvch 337
Cdd:cd17355 214 LLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG----- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 338 LLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFE--TLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYT 415
Cdd:cd17355 289 LALLLLLPFPPLALLLFAALFGLGWGATVPLTaaLAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAA 368
|
410
....*....|....*.
gi 6981542 416 YWACGVILIIAGLYLF 431
Cdd:cd17355 369 WALAVALGLIAALLVL 384
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
19-432 |
8.75e-28 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 114.16 E-value: 8.75e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-----------------------------------------------------LFTNKVFVA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAF-LLSILAFVDMVARPSMGLAANTRWIrpRVQYFFAASVVANGVCH 337
Cdd:cd17429 188 FIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCI 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 338 LLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETlMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYW 417
Cdd:cd17429 266 LILPLMHTYTGLAIVCALIGFSSGYFSLMPVVT-EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFY 344
|
410
....*....|....*
gi 6981542 418 ACGVILIIAGLYLFI 432
Cdd:cd17429 345 VCGLLYMVGIICLLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-432 |
3.47e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.97 E-value: 3.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 100 LIAASFCNTVqELYFCIGVIGGLGLAFNLNPALTMIGKYFYK-KRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:COG2223 84 LLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLnccVAGSLMRPIGPQQGKVEKLKSKESLQEAgksdantdliggspkgeklsvfqtvnkfldLSLFTHRGFLL 258
Cdd:COG2223 163 LILGILLL---VVAVLAWLFLRDPPAGAAAAAKASLRDQ------------------------------LEALRDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSK-HFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVqyFFAASVVANGVCH 337
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRV--LLIVFALMALGLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 338 LLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYW 417
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFL 366
|
410
....*....|....*
gi 6981542 418 ACGVILIIAGLYLFI 432
Cdd:COG2223 367 VFAVLALVALVLTLL 381
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-432 |
1.17e-25 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 107.98 E-value: 1.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLL 258
Cdd:cd17428 161 LIVGALALNLLACGSLMR-----------------------------------------------------LFKNRVFSA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAF-LLSILAFVDMVARPSMGLAANTRWIrpRVQYFFAASVVANGVCH 337
Cdd:cd17428 188 LFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV--NSLYLYVLTLIGMGAAL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 338 LLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETlMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYW 417
Cdd:cd17428 266 LAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFY 344
|
410
....*....|....*
gi 6981542 418 ACGVILIIAGLYLFI 432
Cdd:cd17428 345 FSGFCVLLGGFLLLL 359
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
19-430 |
4.11e-25 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 106.80 E-value: 4.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIF-----SATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGG 93
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 94 CLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFG 173
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 174 WRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKeslqeagksdantdliggspkgeklSVFQTVNKFLDLSLFTH 253
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRK-------------------------FKCPPLKKIFNFNIWKS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 254 RGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVqYFFAASVVAN 333
Cdd:cd17464 216 TGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQVSSFFFI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 334 GVCHLLAPLSTTYVGF---CIYAGVFGfafGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYG 410
Cdd:cd17464 295 GLMSMMIPLCHVFGGLiavCLFMGLFD---GCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLG 371
|
410 420
....*....|....*....|
gi 6981542 411 DYKYTYWACGVILIIAGLYL 430
Cdd:cd17464 372 SYDVAFYLAGVPPIIGGIIL 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-390 |
8.00e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 105.06 E-value: 8.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 13 PPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAG 92
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 93 GCLSGCGLIAASFCNTVQELYFCiGVIGGLGLAFNLNPALTMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGI 171
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 172 FGWRGSFLILGGLllnCCVAGSLMRPIGPQQGKVEKLKSKESLQEagksdantdliggspkgeklsvfqtvnkfldlsLF 251
Cdd:COG2814 161 FGWRWVFLVNAVL---ALLALLLLLRLLPESRPAARARLRGSLRE---------------------------------LL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 252 THRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSK-HFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVqyfFAASV 330
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRL---LLIGL 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 331 VANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIV 390
Cdd:COG2814 281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-390 |
1.01e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 1.01e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 16 GGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCL 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 96 SGCGLIAASFCNTVQELYFCIgVIGGLGLAFNLNPALTMIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFFGIFGW 174
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 175 RGSFLILGGLllncCVAGSLMRpigpqqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfldlslfthr 254
Cdd:COG2271 164 RAAFLILGLP----GLLLALLR---------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 255 gFLLYLSGNVVMFFGLFTPLVFLSNY-GKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVQYFFAASVVAn 333
Cdd:COG2271 182 -FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD-RLGRRRKLVLAIGLLLA- 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 6981542 334 GVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIV 390
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTF 315
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-392 |
7.85e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.41 E-value: 7.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 22 VVVGAFISIGFSYAFPKSITVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLI 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAED---LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 102 AASFCNTVQELYFCiGVIGGLGLAFNLNPALTMIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI 180
Cdd:pfam07690 78 LLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 181 LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLqeagksdantdliggspkgeklsvfqtvnkFLDLSLFTHRGFLLYL 260
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL------------------------------IVAWKALLRDPVLWLL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 261 SGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVQYFFAASVVANGVCHLLA 340
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-RLGRRRRLLLALLLLILAALGLLLL 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 6981542 341 PLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVEC 392
Cdd:pfam07690 286 SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-428 |
2.85e-18 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 86.51 E-value: 2.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFI---SIGFSYAFpksiTVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLS 96
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 97 GCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAG---SPVFLStlaPLNQAFFGIFG 173
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGfglGSLIFS---PLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 174 WRGSFLILG-GLLLNCCVAGSLMRPIGPqqgkveklkskeslqeagksdantdliGGSPKGEKLSVFQTVNKFLDLS--- 249
Cdd:cd17353 156 VPTTFLILGiIFLIIIVIGAFLIRDPPK---------------------------GWVPPGVDPLANNAENSPRDYTpre 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 250 -LFTHRGFLLYLSGNVVMFFGLFTpLVFLSNYGKSKHFSSEKSAFLL-SILAFVDMVARPSMGLAANtRWIRPRVqyFFA 327
Cdd:cd17353 209 mLRTPTFWLLWLMFFLNATAGLML-IGQAKPIGQEFAGLDAGIAALAvSILSIFNGGGRPFWGWLSD-KIGRKNT--LSI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 328 ASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFS-------SAVGLVTIVeccpvllgPP 400
Cdd:cd17353 285 AFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGtnygllyTAKGVGGLI--------GP 356
|
410 420
....*....|....*....|....*...
gi 6981542 401 LLGRLNDMYGDYKYTYWACGVILIIAGL 428
Cdd:cd17353 357 IIAAYVLYTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-427 |
5.64e-18 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 85.54 E-value: 5.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 179 LILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANtdliggspkgeklSVFQTVnkfldlslfthrgFLL 258
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRD-------------KVFWIL-------------FIA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 259 YLSgnvvMFFGLFTPLVFLSNYGKS-KHFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVQYFFAASVVANGVCH 337
Cdd:cd17314 215 IFL----VLIGGFLFIANMASLVRSlQLDAPSFVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 338 LLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYW 417
Cdd:cd17314 290 FLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVY 369
|
410
....*....|
gi 6981542 418 ACGVILIIAG 427
Cdd:cd17314 370 IYAVIVFLAS 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-431 |
1.25e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.40 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 23 VVGAFISIGFSYAfpkSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIA 102
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 103 ASFCNTVQELYFCiGVIGGLGLAFNLNPALTMIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFF--GIFGWRGSFL 179
Cdd:cd06174 78 FAFAPSFWLLLLG-RFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 180 ILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKEslqeagksdantdligGSPKGEKLSVFQTvnkfldlslfthRGFLLY 259
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASS----------------KSVLKLLKRVLKN------------PGLWLL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 260 LSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSA-FLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVvanGVCHL 338
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAgLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM---ALGLA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 418
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLV 365
|
410
....*....|...
gi 6981542 419 CGVILIIAGLYLF 431
Cdd:cd06174 366 LAVLLLLAAILLL 378
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
57-431 |
5.41e-16 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 79.46 E-value: 5.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 57 EVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIG 136
Cdd:cd17465 44 KTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 137 KYFYKKRPLANGLAMAGSPVFlSTLAPLnqaffgifgwrgsflilgglllnccvagsLMRPIGpqqgkvEKLKSKESLQe 216
Cdd:cd17465 124 HYFRRRLGLANGVVTAGSSLF-SMLLPF-----------------------------LLKMVG------DAIGLAHTFQ- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 217 agksdantdliggspkgeKLSVFQTVNKFLDLS--LFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFL 294
Cdd:cd17465 167 ------------------VLSLFMFIQIFLSLTykVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 295 LSILAFVDMVARPSMGLAANTrWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDL 374
Cdd:cd17465 229 LVCIGASSGIGRLMSGKIGDL-IPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFEL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 6981542 375 VGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLF 431
Cdd:cd17465 308 VGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLF 364
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-387 |
9.04e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.07 E-value: 9.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 12 TPPDGGWGWAVVVGAFISIGFSYAFP-KSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMI 90
Cdd:COG2807 8 ARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 91 AGGCLSGCGLIAASFCNTVQELYFCIGVIG-GLGLAFNLNPALtmIGKYFYKKRPLANGLA----MAGSPVFLSTLAPLN 165
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYtaamGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 166 QAffgiFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGkveklkskeslqeagksdantdliGGSPKGEKLsvfqtvnkf 245
Cdd:COG2807 166 AA----LGWRGALAVWALLALLALLLWLPLLRRRPAAA------------------------AAAPAAASL--------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 246 ldLSLFTHRGFLLylsgnVVMFFGL-----FTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRP 320
Cdd:COG2807 209 --RSLWRSPLAWL-----LTLFFGLqsllyYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDR 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981542 321 RVQYFFAASVVANGVCHLL-APLSTTYVgfciYAGVFGFAFGWLSSVLFETLMDLVG-PQRFSSAVGLV 387
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLlAPGSLPWL----WAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMA 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-433 |
5.14e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 5.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 53 ATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFcIGVIGGLGLAFNLNPAL 132
Cdd:cd17325 28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL-ARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 133 TMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPigpqqgkvEKLKSK 211
Cdd:cd17325 107 ALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP--------EPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 212 ESlqeagksdantdliggspkgeKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMF-FGLFTPlvFLSNYGKSK-HFSSE 289
Cdd:cd17325 179 NK---------------------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFaFGALEP--FLPLYAAELgGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 290 KSAFLLSILAFVDMVARPSMGLAANtRWIRPRVqyfFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFE 369
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSD-RIGRKPL---ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981542 370 TLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGdYKYTYWACGVILIIAGLYLFIG 433
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
51-386 |
2.56e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFcIGVIGGLGLAFNLNP 130
Cdd:cd17474 29 LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA-GRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 131 ALTMIGKYF-YKKRP-------LANGLAMAGSPVFLSTLaplnqaffGIFGWRGSFLILGGLLLnccVAGSLMRPIGPQQ 202
Cdd:cd17474 108 ALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLL--------AAISWRYPFFLLAALIP---VAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 203 GKVEKLKSKESLQEAGKsdantdliggspkgeklsvfqtvnkfldlsLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNY-G 281
Cdd:cd17474 177 KEKAKSSSATKLRDLKK------------------------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLlE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 282 KSKHFSSEKSAFLLSILAFVDMVARPSMGlaantRWIRPRV--QYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFA 359
Cdd:cd17474 227 LLYGISPIIIGLLFAGWSVLLALGSLFVG-----RLLKKRFgaRRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301
|
330 340
....*....|....*....|....*..
gi 6981542 360 FGWLSSVLFETLMDLVGPQRFSSAVGL 386
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEERGTASSL 328
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
40-186 |
1.47e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 40 ITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIgVI 119
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR-AL 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981542 120 GGLGLAFNLNPALTMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLL 186
Cdd:COG0477 112 QGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL 179
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-390 |
1.80e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.32 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 21 AVVVGAFISIGFSYAFPKSITVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGL 100
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDA---FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 101 IAASFCNTVQELYFCIGVIgGLGLAF---NLNPALTMIGKYFYKKR-PLA---NGLAMAGSPVFLSTLAPLNQAffgiFG 173
Cdd:COG0738 88 LLFALAPSYPLLLLALFLL-GLGLGLldvAANPYVAALGPETAASRlNLLhafFSLGALLGPLLGGLLILLGLS----LS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 174 WRGSFLILGGLLLNCCVAGSLMRpigpqqgkveklkskesLQEAGKSDANTDLIGGSPKgeklsvfqtvnkfldlSLFTH 253
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSK-----------------LPEIEEEEEEAAGSAASLK----------------SLLKN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 254 RGFLLYLSGNVVMFFGLFTPLVFLSNYGKS-KHFSSEKSAFLLSILAFVDMVARPSMGLAanTRWIRPRVqyFFAASVVA 332
Cdd:COG0738 210 PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFL--LKRFGPVR--LLRLSALL 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 6981542 333 NGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFeTLMDLVGPQRFSSAVGLVTIV 390
Cdd:COG0738 286 AAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF-SLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-184 |
2.22e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.96 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCG 99
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 100 LIAASFCNTVQELYFCIGVIgGLGLAFNLNPALTMIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSF 178
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
....*.
gi 6981542 179 LILGGL 184
Cdd:cd17319 161 IIEGLL 166
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-388 |
3.04e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 73 GPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGgLGLAFNLNPALTMIGKYFY-KKRPLANGLAM 151
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG-IGVAGIMTLATALIGDYFEgEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 152 AGSPvFLSTLAPLNQAFFGIFGWRGSFLI-LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLqeagksdantdliggs 230
Cdd:cd17473 131 AAMS-LGGVVFLLLGGALAEIGWRAPFLVyLLALPVLILVLLFLPEPARKSKSAASPGAATAAA---------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 231 pkgeklsvfqtvnkfldlslFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKH-FSSEKSAFLLSILAFVDMVARPSM 309
Cdd:cd17473 194 --------------------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981542 310 GLAAntRWIRPRVQYFFAASVVANGvcHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVT 388
Cdd:cd17473 254 GRLK--RRLGKRRLLAIGFALMALG--FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-197 |
8.88e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 8.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSR--PVMIAGGCLSG 97
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEV---RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 98 CGLIAASFCNTVQELYFCIGVIGGLGLAFnlNPALTMIGKYFY--KKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWR 175
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGA--FGLLWALAAELFpkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 6981542 176 GSFLILGGLLLNCCVAGSLMRP 197
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-126 |
2.68e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFkeIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCG 99
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100
....*....|....*....|....*...
gi 6981542 100 LIAASFCNTVQ-ELYFCIGVIGGLGLAF 126
Cdd:COG2211 308 LLLLFFLGPGNlWLLLVLAALAGIGLGA 335
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
260-386 |
9.45e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 9.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 260 LSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPrvqyFFAASVVANGVCHLL 339
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKR----LLLIGLLIFALATLL 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 6981542 340 APLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGL 386
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGY 124
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
51-390 |
9.94e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 9.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTvQELYFCIGVIGGLGLAFNLNP 130
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYGSVQPG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 131 ALTMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAgsLMRPIGPQQGKVEKLK 209
Cdd:cd17475 105 GGRAIMRWFpPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL--FWLFYREPPAASAATE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 210 SKESLQEAGKsdantdliggspkgeklsvfqtvnkfldlSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSK-HFSS 288
Cdd:cd17475 183 SASTLLRSLK-----------------------------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 289 EKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANG--VCHLLAPLSTTY---VGFCIYAGVFGFAFGWL 363
Cdd:cd17475 234 VAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAalLVLSLLSPGTPLwllVLLLILLGLFAIGWNGL 313
|
330 340
....*....|....*....|....*...
gi 6981542 364 SSVLfetLMDLVGPQRFSSAVGL-VTIV 390
Cdd:cd17475 314 YLTL---VAESAGPEQAGTALGLaNTIN 338
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
51-390 |
1.86e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFcIGVIGGLGLAFNLNP 130
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII-FRILQGFGGGVLIPL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 131 ALTMIGKYfYKKRPLANGLAMAGSPVflsTLAP-LNQAFFGI----FGWRGSFLIlgglLLNCCVAGSLMRPIgpqqgkv 205
Cdd:cd17503 105 AQTILLRI-YPPEKRGAAMGLVGLVI---LLAPaIGPTLGGWltdnLSWRWIFYI----NLPIGILALLLAPL------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 206 eklkskeslqeagksdantdliggspkgeklsvfqtvnkfLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNY-GKSK 284
Cdd:cd17503 170 ----------------------------------------LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYlQNVL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 285 HFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAgVFGFAFGWLS 364
Cdd:cd17503 210 GYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF-IRGLGMGLVF 288
|
330 340
....*....|....*....|....*.
gi 6981542 365 SVLFETLMDLVGPQRFSSAVGLVTIV 390
Cdd:cd17503 289 MPLNTLALNSLPPEQIGDATALFNTI 314
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-182 |
2.14e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.18 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 73 GPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCiGVIGGLGLAFNLNPALTMIGKYF-YKKRPLANGLAM 151
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYpPEERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|.
gi 6981542 152 AGSPVFLSTLAPLNQAFFGIFGWRGSFLILG 182
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-135 |
2.38e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 17 GWGWAVVVGAFISIGFsYAFPKSITVFFKeieIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLS 96
Cdd:cd17321 169 TFSGAVLAAFLLGAAL-GGLLFLLPLYLQ---GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 6981542 97 GCGLIAASFCNTVQELYFCIG--VIGGLGLAFNLNPALTMI 135
Cdd:cd17321 245 AVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATPLTNAA 285
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
26-186 |
4.71e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.39 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 26 AFISIGFSYAFPKSITVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASF 105
Cdd:cd17333 4 SFFSNGLTDALLGILGPSLEEA---FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 106 CNTVQeLYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLaMAGSPVFLSTLAPLNQAFFG--IFGWRGSFLILGG 183
Cdd:cd17333 81 TPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNV-LHGFFGLGALIGPLIATSLLtsELSWSWAYLIIGL 158
|
...
gi 6981542 184 LLL 186
Cdd:cd17333 159 IYL 161
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
54-195 |
6.52e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 6.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 54 TTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFcIGVIGGLGLAFNLNPALT 133
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981542 134 MIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNC--CVAGSLM 195
Cdd:cd17365 111 LVSEYAPARrRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILlpLLRGTLL 175
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-379 |
2.82e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.92 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFC-IGVIGGLGLAFNLn 129
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLArALAGLAHGGFWAI- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 130 pALTMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLnccVAGSLMRPIGPQQGKVEKL 208
Cdd:cd17324 108 -AAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL---LAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 209 KSKESLQEagksdantdliggspkgeklsvfqtvnkfldLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSK-HFS 287
Cdd:cd17324 184 SLGLLSSL-------------------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 288 SEKSAFLLSILAFVDMVARPSMGLAANTRWIRPrvqyFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVL 367
Cdd:cd17324 233 SSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL 308
|
330
....*....|..
gi 6981542 368 FETLMDLVGPQR 379
Cdd:cd17324 309 QTRVLRLAPEAR 320
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-186 |
3.03e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.03 E-value: 3.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAvMYAGGP-ISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIG---GLGLAfnlnPALTMIGKYFYKK-RPLANGLaMAGSPVFLSTLAPLNQAFF-GIFG 173
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFSKKeRGTVYGI-WSTSHNFGGILAPILAASLaSYYG 155
|
170
....*....|...
gi 6981542 174 WRGSFLILGGLLL 186
Cdd:cd17312 156 WRAAFLVPGIVGL 168
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-196 |
3.58e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.95 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 19 GWAVVVGAFISIGFSYAFPksitVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLP----LYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVQELYFCIGVIgGLGLAFNLNPALTMIGKYFykkRPLANGLAMAGSPVFLS---TLAPLNQAF-FGIFGW 174
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALL-GLGLGLVFPATLALLADIV---PPEGRGTAMGLFNTAFSlgmVLGPLLGGFlYDAFGF 353
|
170 180
....*....|....*....|..
gi 6981542 175 RGSFLILGGLLLNCCVAGSLMR 196
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
65-135 |
4.12e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 4.12e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6981542 65 MLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMI 135
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-196 |
7.51e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 7.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFISIGFSYAFPKSITVFFKEIeiiFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCG 99
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQ---FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 100 LIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYF-YKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFG-WRGS 177
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
|
170
....*....|....*....
gi 6981542 178 FLILGGLLLNCCVAGSLMR 196
Cdd:COG2223 365 FLVFAVLALVALVLTLLLY 383
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
51-182 |
8.92e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 8.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFcIGVIGGLGLAFNLNP 130
Cdd:TIGR00895 47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPN 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 6981542 131 ALTMIGKYFYKK-RPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILG 182
Cdd:TIGR00895 126 LNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGG 178
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-359 |
4.43e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 20 WAVVVGAFI-SIGFSYAFPkSITVFFKEiEIIFSATTseVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGC 98
Cdd:cd17329 2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQ-QLGLSASI--VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 99 GLIAASFCNTVqeLYFCIG-VIGGLGLAFNLNPALTMIG--------KYFYKKRPLANGLAMAgspvflstLAPLNQAFF 169
Cdd:cd17329 78 GFALLGFAHSP--WLFAIAlVLTGFGGGLFEPASEAMIAdvttpenrTRAFSLLYWAINLGVA--------IGPLLGGLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 170 GIFGWRGSFLILGGLLLNCC-VAGSLMRPIGPQQGKVEKLKSKESLQeagksdantdliggspkgeklsvfqtvnkfldl 248
Cdd:cd17329 148 LLYSFRLLFLAAAVLFLLAAlVLLFLLPETRPKRRAAEKTEILRGYK--------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 249 SLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKS-AFLLSILAFVDMVARPSMglaanTRWI-RPRVQYFF 326
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPV-----ARLVeRFRLRKIL 269
|
330 340 350
....*....|....*....|....*....|...
gi 6981542 327 AASVVANGVCHLLAPLSTTYVGFCIYAGVFGFA 359
Cdd:cd17329 270 MIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-361 |
4.85e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.10 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 44 FKEIEIIFSATTSEVSWISSIMLAVMYAG----GPISSilvnKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCiGVI 119
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSD----RFGRRPVLLAGLLLFILASLLCALASSIEQLLIA-RFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 120 GGLGLAFNLNPALTMI-GKYFYKKRPLANGLAMAG---SPVflstLAP-LNQAFFGIFGWRGSFLILGGLLLNCCVAGSL 194
Cdd:cd17320 97 QGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIlaiAPA----LAPlLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 195 MRPigpqqgkvEKLKSKESlqeagksdantdligGSPKGEKLSVFqtvnkfldLSLFTHRGFLLYLSGNVVMFFGLFT-- 272
Cdd:cd17320 173 FLP--------ETLPEEKR---------------KPLLSSLLRAY--------KRVLKNRRFLGYALALGLSFAGLFAyl 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 273 ---PLVFLSNYGkskhFSSEKSAFLLSILAFVDMVARPSMGLAAN---TRWIRPRVQYFFAASVVANGVCHLLAPLSTTY 346
Cdd:cd17320 222 aaaPFIYIEQLG----LSPAQFGLLFALNAIALILGSLLNGRLVRrfgPRRLLRLGLLLLLAAALVLLLAALLGGLSLWP 297
|
330
....*....|....*..
gi 6981542 347 --VGFCIYAGVFGFAFG 361
Cdd:cd17320 298 lvAPLFLIFFGFGLIFP 314
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-386 |
6.73e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 47 IEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCiGVIGGLGLAf 126
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG-RALQGIGGA- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 127 nLNP-ALTMIGKYFYKKR-PLANGL--AMAGSPVFLSTL--APLNQaffgIFGWRGSFLILGGLllncCVAGSLMRPIgp 200
Cdd:cd17504 100 -VFPlAFALVREEFPPERvPVAQGIlsATFGIGAGIGLPlgGWIVQ----HLGWRWIFWTAAPV----AVLLAALVPL-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 201 qqgkveklkskeslqeagksdantdliggspkgeklsvfqtvnkfLDLSLFTHRGFLLYLSGNVVMFFGLFT-----PLV 275
Cdd:cd17504 169 ---------------------------------------------IDLRLLRRRNVLLANITALLAGFGMFMvfqllPQL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 276 FLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTrwIRPRVQYFFAASVVANGVChLLAPLSTTYVGFCIYAGV 355
Cdd:cd17504 204 LQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLL 280
|
330 340 350
....*....|....*....|....*....|.
gi 6981542 356 FGFAFGWLSSVLFETLMDLVGPQRFSSAVGL 386
Cdd:cd17504 281 IGIGLGLAFASLPNIVVESVPPDRTGIATGM 311
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-432 |
6.84e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 6.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 260 LSGNVVMFFGLFTPLVFLSNY-GKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANtRWIRPRVqyfFAASVVANGVCHL 338
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGRRRV---LLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 339 LAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGdYKYTYWA 418
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 6981542 419 CGVILIIAGLYLFI 432
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-388 |
7.05e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 51 FSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELyfcIG--VIGGLGLAFnL 128
Cdd:cd17321 26 LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL---IAarALQGIGAAA-I 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 129 NPALTMIGKYFYKKRPLANGLAMAGSPVFLST-LAPLNQAFFG-IFGWRGSFLILGGLLLnccvagslmrpigpqqgkve 206
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAaLGPLLGGLLLeLFGWRWIFLINVPIGL-------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 207 klkskeslqeagksdantdliggspkgeklsvfqtvnkfldLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKS-KH 285
Cdd:cd17321 162 -----------------------------------------VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981542 286 FSSEKSAFLLSILAFVDMVARPSMGLAAntRWIRPRVQYFFAASVVANGVCHL-LAPLSTTYVGFCIYAGVFGFAFGWLS 364
Cdd:cd17321 201 YSPLQAGLALLPLALAMLVAAPLAGRLA--DRFGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFA 278
|
330 340
....*....|....*....|....
gi 6981542 365 SVLFETLMDLVGPQRFSSAVGLVT 388
Cdd:cd17321 279 TPLTNAALSSVPKEKAGAASGILN 302
|
|
| |
