NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|697634637|emb|CEA17114|]
View 

glycerol-3-phosphate dehydrogenase [Fermentimonas caenicola]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11415519)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

CATH:  1.10.1040.10|3.40.50.720
EC:  1.1.1.-
Gene Ontology:  GO:0051287|GO:0047952|GO:0009331|GO:0046167|GO:0006072
SCOP:  4000111

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-327 2.64e-132

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 379.77  E-value: 2.64e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKiPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELP-GALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHY 245
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 246 LGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ..
gi 697634637 326 NL 327
Cdd:COG0240  320 AL 321
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-327 2.64e-132

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 379.77  E-value: 2.64e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKiPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELP-GALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHY 245
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 246 LGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ..
gi 697634637 326 NL 327
Cdd:COG0240  320 AL 321
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-327 4.06e-85

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 259.62  E-value: 4.06e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLP-DNLRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKiPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELP-DLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMS-------------LFLnT 232
Cdd:PRK00094 161 ERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITrlgvalganpetfLGL-A 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 233 VvpiernitdqhyLGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYK 312
Cdd:PRK00094 240 G------------LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYA 307

                        330
                 ....*....|....*
gi 697634637 313 ILYERLEPKSAIKNL 327
Cdd:PRK00094 308 VLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 184-325 1.25e-55

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 177.58  E-value: 1.25e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  184 DVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHYLGDMLVTSYSQFSRNRTL 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 697634637  264 GTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-321 1.70e-36

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 134.01  E-value: 1.70e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637    6 KICILGGGTWGTALAKMVLMN-QKHINWFIRR------DDQIEG------FYKLGHNPSYLTNVKFNlAQITFYSNLERA 72
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaRALPELFEESvrmwvfEEEIEGrnlteiINTTHENVKYLPGIKLP-ANLVAVPDLVEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   73 IKDSDTVIIAIPSPYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMV--MSEYLADNFKIPtenIGVLSGPCHAEEVALE 150
Cdd:TIGR03376  80 AKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVklLSDIIEEELGIP---CGVLSGANLANEVAKE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  151 RLSFLTAASKDIEKANLLSESIssRILKTRTS------NDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAK 224
Cdd:TIGR03376 157 KFSETTVGYRDPADFDVDARVL--KALFHRPYfrvnvvDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  225 EMSLFLNTVVP-IERNITDQHY-LGDMLVTSYSqfSRNRTLGTMIGKgySVKTAQ-LEMEMI----AEGYYGAKCIHEM- 296
Cdd:TIGR03376 235 EMIKFARMFFPtGEVTFTFESCgVADLITTCLG--GRNFKVGRAFAK--TGKSLEeLEKELLngqsLQGVATAKEVHELl 310

                         330       340
                  ....*....|....*....|....*.
gi 697634637  297 -NNRFKVNIPIVETVYKILYERLEPK 321
Cdd:TIGR03376 311 kNKNKDDEFPLFEAVYQILYEGLPPK 336
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-327 2.64e-132

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 379.77  E-value: 2.64e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLP-ENLRATSDLEEALAGADLVLLAVPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKiPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELP-GALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHY 245
Cdd:COG0240  160 ERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 246 LGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319


                 ..
gi 697634637 326 NL 327
Cdd:COG0240  320 AL 321
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-327 4.06e-85

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 259.62  E-value: 4.06e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLP-DNLRATTDLAEALADADLILVAVPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKiPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELP-DLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMS-------------LFLnT 232
Cdd:PRK00094 161 ERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITrlgvalganpetfLGL-A 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 233 VvpiernitdqhyLGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYK 312
Cdd:PRK00094 240 G------------LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYA 307

                        330
                 ....*....|....*
gi 697634637 313 ILYERLEPKSAIKNL 327
Cdd:PRK00094 308 VLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 184-325 1.25e-55

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 177.58  E-value: 1.25e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  184 DVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHYLGDMLVTSYSQFSRNRTL 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 697634637  264 GTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-328 2.43e-50

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 170.05  E-value: 2.43e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   1 MDSIGKICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVI 80
Cdd:PRK14618   1 MHHGMRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVALP-AELYPTADPEEALAGADFAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  81 IAIPSPYVkqyfRRIWNSTFRGKFMVSALKGIIPNDNMVmSEYLADNFKIPTENIGVLSGPCHAEEVALERLSFLTAASK 160
Cdd:PRK14618  80 VAVPSKAL----RETLAGLPRALGYVSCAKGLAPDGGRL-SELARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 161 DIEKANLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNI 240
Cdd:PRK14618 155 EPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEEATF 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 241 TDQHYLGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQlEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEP 320
Cdd:PRK14618 235 YGLSGLGDLIATATSPHSRNRAAGEAIVRGVDREHLE-AGGKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARGGWDP 313


                 ....*...
gi 697634637 321 KSAIKNLI 328
Cdd:PRK14618 314 LAGLRSLM 321
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-328 1.16e-45

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 158.41  E-value: 1.16e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWfIRRDDQIEGFYKLGHNPSYLTNVKFNLAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:PRK12439   9 KVVVLGGGSWGTTVASICARRGPTLQW-VRSAETADDINDNHRNSRYLGNDVVLSDTLRATTDFAEAANCADVVVMGVPS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADnfKIPTENIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:PRK12439  88 HGFRGVLTELAKELRPWVPVVSLVKGLEQGTNMRMSQIIEE--VLPGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 166 NLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMSLFLNTVVPIERNITDQHY 245
Cdd:PRK12439 166 TRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPETFAGLAG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 246 LGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPKSAIK 325
Cdd:PRK12439 246 MGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIAREVDAVINHGSTVEQAYR 325


                 ...
gi 697634637 326 NLI 328
Cdd:PRK12439 326 GLI 328
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-321 1.70e-36

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 134.01  E-value: 1.70e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637    6 KICILGGGTWGTALAKMVLMN-QKHINWFIRR------DDQIEG------FYKLGHNPSYLTNVKFNlAQITFYSNLERA 72
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaRALPELFEESvrmwvfEEEIEGrnlteiINTTHENVKYLPGIKLP-ANLVAVPDLVEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   73 IKDSDTVIIAIPSPYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMV--MSEYLADNFKIPtenIGVLSGPCHAEEVALE 150
Cdd:TIGR03376  80 AKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVklLSDIIEEELGIP---CGVLSGANLANEVAKE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  151 RLSFLTAASKDIEKANLLSESIssRILKTRTS------NDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAK 224
Cdd:TIGR03376 157 KFSETTVGYRDPADFDVDARVL--KALFHRPYfrvnvvDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  225 EMSLFLNTVVP-IERNITDQHY-LGDMLVTSYSqfSRNRTLGTMIGKgySVKTAQ-LEMEMI----AEGYYGAKCIHEM- 296
Cdd:TIGR03376 235 EMIKFARMFFPtGEVTFTFESCgVADLITTCLG--GRNFKVGRAFAK--TGKSLEeLEKELLngqsLQGVATAKEVHELl 310

                         330       340
                  ....*....|....*....|....*.
gi 697634637  297 -NNRFKVNIPIVETVYKILYERLEPK 321
Cdd:TIGR03376 311 kNKNKDDEFPLFEAVYQILYEGLPPK 336
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 6-165 7.22e-34

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 121.92  E-value: 7.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637    6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVIIAIPS 85
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLP-ENLKATTDLAEALKGADIIVIVVPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   86 PYVKQYFRRIWNSTFRGKFMVSALKGIIPNDNMVMSEYLADNFKIPTEnIGVLSGPCHAEEVALERLSFLTAASKDIEKA 165
Cdd:pfam01210  80 QALREVLKQLKGLLKPDAILVSLSKGIEPGTLKLLSEVIEEELGIQPP-IAVLSGPSHAEEVAQGLPTATVIASKDEEAA 158
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-329 7.44e-34

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 126.26  E-value: 7.44e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   1 MDSIGKICILGGGTWGTALAKMVLMNQKHINWFIRRDDQiegfyklghnpsyltnvkfnlaqitfysNLERAIKDSDTVI 80
Cdd:PRK14619   1 TTQPKTIAILGAGAWGSTLAGLASANGHRVRVWSRRSGL----------------------------SLAAVLADADVIV 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  81 IAIPSPYVKQYFRRIWNSTFR-GKFMVSALKGIIPNDNMVMSEYLADNFkiPTENIGVLSGPCHAEEVALERLSFLTAAS 159
Cdd:PRK14619  53 SAVSMKGVRPVAEQVQALNLPpETIIVTATKGLDPETTRTPSQIWQAAF--PNHPVVVLSGPNLSKEIQQGLPAATVVAS 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 160 KDIEKANLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMslflntvvpiern 239
Cdd:PRK14619 131 RDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEM------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 240 ITDQHY-------------LGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPI 306
Cdd:PRK14619 198 IRVGTHlgaqtetfyglsgLGDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGVNTANVLVQLAQQQNIAVPI 277

                        330       340
                 ....*....|....*....|...
gi 697634637 307 VETVYKILYERLEPKSAIKNLID 329
Cdd:PRK14619 278 TEQVYRLLQGEITPQQALEELME 300
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 6-327 8.45e-33

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 124.75  E-value: 8.45e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWF---IR---RDDQIEGFY------KLGHNPSYLTNVKF--NlaqITFYSNLER 71
Cdd:PTZ00345  13 KVSVIGSGNWGSAISKVVGENTQRNYIFhneVRmwvLEEIVEGEKlsdiinTKHENVKYLPGIKLpdN---IVAVSDLKE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  72 AIKDSDTVIIAIPSPYVKQYFRRI--WNSTFRGKFMVSALKGIIPNDN--MVMSEYLADNFKIPtenIGVLSGPCHAEEV 147
Cdd:PTZ00345  90 AVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGkpVLCSDVIEEELGIP---CCALSGANVANDV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 148 ALERLSFLTAASKDIEKANLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEMS 227
Cdd:PTZ00345 167 AREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMK 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 228 LFLNTVVPierNITDQHY-----LGDMLVTSYSqfSRNRTLGTMIGKGYSVKT-AQLEMEMIA----EGYYGAKCIHEM- 296
Cdd:PTZ00345 247 LFGKIFFP---NVMDETFfescgLADLITTCLG--GRNVRCAAEFAKRNGKKSwEEIEAELLNgqklQGTVTLKEVYEVl 321

                        330       340       350
                 ....*....|....*....|....*....|..
gi 697634637 297 -NNRFKVNIPIVETVYKILYERLEPKSAIKNL 327
Cdd:PTZ00345 322 eSHDLKKEFPLFTVTYKIAFEGADPSSLIDVL 353
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-328 1.98e-32

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 123.02  E-value: 1.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637   6 KICILGGGTWGTALAKMVLMNQKHINWFIRRDDQIEGFYKLGHNPSYLTNVKFNlAQITFYSNLERAIKDSDTVII-AIP 84
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHLP-DNISVKSAIDEVLSDNATCIIlAVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637  85 SPYVKQYFRRIWN-STFRGKFMVSALKGIIPNDNMVMSEYLadNFKIPTENIGVLSGPCHAEEVALERLSFLTAASKDIE 163
Cdd:PRK14620  81 TQQLRTICQQLQDcHLKKNTPILICSKGIEKSSLKFPSEIV--NEILPNNPIAILSGPSFAKEIAEKLPCSIVLAGQNET 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 164 KANLLSESISSRILKTRTSNDVVGIELAAVLKNIYAIASGICQGLLYGDNFQAVLMSNCAKEM-SLFLNTVVPIERN-IT 241
Cdd:PRK14620 159 LGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIkTLYSAKNGSIDLNtLI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697634637 242 DQHYLGDMLVTSYSQFSRNRTLGTMIGKGYSVKTAQLEMEMIAEGYYGAKCIHEMNNRFKVNIPIVETVYKILYERLEPK 321
Cdd:PRK14620 239 GPSCLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLLYENISLE 318


                 ....*..
gi 697634637 322 SAIKNLI 328
Cdd:PRK14620 319 KTISVIL 325
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 245-310 1.01e-20

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 84.09  E-value: 1.01e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697634637  245 YLGDMLVTSYSQFSRNRTLGTMIGKGYSVktAQLEMEMIAEGYYGAKCI-HEMNNRFKVNIPIVETV 310
Cdd:pfam20618   2 GLGDLVLTCTSDLSRNRTFGLLLGKGMTL--AEAGNGQVAEGVRTAKAVaAILARAHNVEMPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH