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Conserved domains on  [gi|696228051|ref|WP_032808259|]
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50S ribosomal protein L16 [Oenococcus oeni]

Protein Classification

50S ribosomal protein L16( domain architecture ID 10785085)

50S ribosomal protein L16 binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
1-136 9.55e-80

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


:

Pssm-ID: 439967  Cd Length: 136  Bit Score: 231.46  E-value: 9.55e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051   1 MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVG 80
Cdd:COG0197    1 MLMPKRVKYRKQQRGRIKGVAKRGNKFAFGNYGLKALEPGQITSRQIEAARIAITRYLKRGGKVWIRIFPDKPLTKKPAE 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 696228051  81 VRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSKAE 136
Cdd:COG0197   81 TRMGAGKGKPEGWVAVVKPGRILFEIAGVSEEVAKEALRLAAHKLPIKTRIVVREE 136
 
Name Accession Description Interval E-value
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
1-136 9.55e-80

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 231.46  E-value: 9.55e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051   1 MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVG 80
Cdd:COG0197    1 MLMPKRVKYRKQQRGRIKGVAKRGNKFAFGNYGLKALEPGQITSRQIEAARIAITRYLKRGGKVWIRIFPDKPLTKKPAE 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 696228051  81 VRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSKAE 136
Cdd:COG0197   81 TRMGAGKGKPEGWVAVVKPGRILFEIAGVSEEVAKEALRLAAHKLPIKTRIVVREE 136
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
4-127 1.02e-65

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 195.67  E-value: 1.02e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051    4 PKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVGVRM 83
Cdd:TIGR01164   2 PKRTKYRKQQRGRVKGKAKRGNTVAFGEYGLQALEPGWITARQIEAARVAMTRYVKRGGKLWIRIFPDKPYTKKPLETRM 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 696228051   84 GNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPV 127
Cdd:TIGR01164  82 GKGKGNPEYWVAVVKPGKILFEIAGVPEEVAREAFRLAASKLPI 125
rpl16 CHL00044
ribosomal protein L16
1-134 4.40e-65

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 194.34  E-value: 4.40e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051   1 MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVG 80
Cdd:CHL00044   1 MLSPKRTKFRKQHRGRMKGISYRGNRICFGRYALQALEPAWITSRQIEAGRRAITRYARRGGKIWIRIFPDKPVTMRPAE 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 696228051  81 VRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSK 134
Cdd:CHL00044  81 TRMGSGKGSPEYWVAVVKPGRILYEMGGVSETIARAAIKIAAYKMPIKTQFIIS 134
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
4-132 2.03e-64

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 192.64  E-value: 2.03e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051    4 PKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMK--RGGKVWIKIFPQKSYTSKGVGV 81
Cdd:pfam00252   1 PKRTKYRKSRKRYIRGVPTKGTTLDFGDYGLVALEGGQITARQLEAARIAINRYLKktRGGKLWIRVFPDKPVTKKPGED 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 696228051   82 RMGNGKGAPEGWVAPTKRGTIMFEV-GGVSEAVAKEALRLAMHKLPVKAKIV 132
Cdd:pfam00252  81 RMGKGKGKPEGWVARVKPGRILFEIkGGVHEEVAKEALRLAAHKLPGKTKIV 132
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
24-132 2.53e-47

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 148.41  E-value: 2.53e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051  24 GRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKR-GGKVWIKIFPQKSYTSKGVGVRMGNGKGAPEGWVAPTKRGTI 102
Cdd:cd01433    2 GNKLFFGEYGLVALEPGRITAEQLEAARIAINRYLKKkGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPGQI 81
                         90       100       110
                 ....*....|....*....|....*....|.
gi 696228051 103 MFEVGGVS-EAVAKEALRLAMHKLPVKAKIV 132
Cdd:cd01433   82 LFEVRGVPeEEVAKEALRRAAKKLPIKTKIV 112
 
Name Accession Description Interval E-value
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
1-136 9.55e-80

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 231.46  E-value: 9.55e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051   1 MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVG 80
Cdd:COG0197    1 MLMPKRVKYRKQQRGRIKGVAKRGNKFAFGNYGLKALEPGQITSRQIEAARIAITRYLKRGGKVWIRIFPDKPLTKKPAE 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 696228051  81 VRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSKAE 136
Cdd:COG0197   81 TRMGAGKGKPEGWVAVVKPGRILFEIAGVSEEVAKEALRLAAHKLPIKTRIVVREE 136
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
4-127 1.02e-65

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 195.67  E-value: 1.02e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051    4 PKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVGVRM 83
Cdd:TIGR01164   2 PKRTKYRKQQRGRVKGKAKRGNTVAFGEYGLQALEPGWITARQIEAARVAMTRYVKRGGKLWIRIFPDKPYTKKPLETRM 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 696228051   84 GNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPV 127
Cdd:TIGR01164  82 GKGKGNPEYWVAVVKPGKILFEIAGVPEEVAREAFRLAASKLPI 125
rpl16 CHL00044
ribosomal protein L16
1-134 4.40e-65

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 194.34  E-value: 4.40e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051   1 MLVPKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKRGGKVWIKIFPQKSYTSKGVG 80
Cdd:CHL00044   1 MLSPKRTKFRKQHRGRMKGISYRGNRICFGRYALQALEPAWITSRQIEAGRRAITRYARRGGKIWIRIFPDKPVTMRPAE 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 696228051  81 VRMGNGKGAPEGWVAPTKRGTIMFEVGGVSEAVAKEALRLAMHKLPVKAKIVSK 134
Cdd:CHL00044  81 TRMGSGKGSPEYWVAVVKPGRILYEMGGVSETIARAAIKIAAYKMPIKTQFIIS 134
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
4-132 2.03e-64

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 192.64  E-value: 2.03e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051    4 PKRVKYRRVHRGHMRGEAKGGRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMK--RGGKVWIKIFPQKSYTSKGVGV 81
Cdd:pfam00252   1 PKRTKYRKSRKRYIRGVPTKGTTLDFGDYGLVALEGGQITARQLEAARIAINRYLKktRGGKLWIRVFPDKPVTKKPGED 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 696228051   82 RMGNGKGAPEGWVAPTKRGTIMFEV-GGVSEAVAKEALRLAMHKLPVKAKIV 132
Cdd:pfam00252  81 RMGKGKGKPEGWVARVKPGRILFEIkGGVHEEVAKEALRLAAHKLPGKTKIV 132
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
24-132 2.53e-47

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 148.41  E-value: 2.53e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051  24 GRTVAFGDYGLQSLENNWITNRQIEAARIAITRYMKR-GGKVWIKIFPQKSYTSKGVGVRMGNGKGAPEGWVAPTKRGTI 102
Cdd:cd01433    2 GNKLFFGEYGLVALEPGRITAEQLEAARIAINRYLKKkGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPGQI 81
                         90       100       110
                 ....*....|....*....|....*....|.
gi 696228051 103 MFEVGGVS-EAVAKEALRLAMHKLPVKAKIV 132
Cdd:cd01433   82 LFEVRGVPeEEVAKEALRRAAKKLPIKTKIV 112
PTZ00173 PTZ00173
60S ribosomal protein L10; Provisional
36-132 1.85e-05

60S ribosomal protein L10; Provisional


Pssm-ID: 185498  Cd Length: 213  Bit Score: 42.71  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051  36 SLENNWITNRQIEAARIAITRYM-KRGGK----VWIKIFP------QKSYTSKG-----VGVRMGNGKgaPEGWVAPTKR 99
Cdd:PTZ00173  54 SDEYEQISSEALEAARISANKYMvKRAGKdgfhLRIRVHPfhvlriNKMLSCAGadrlqTGMRGAFGK--PNGTCARVRI 131
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 696228051 100 GTIMFEVGGVSEAV--AKEALRLAMHKLPVKAKIV 132
Cdd:PTZ00173 132 GQILLSIRTKEAYVpqAIEALRRAKYKFPGRQKIV 166
rpl10e PRK04199
50S ribosomal protein L16;
47-132 9.70e-05

50S ribosomal protein L16;


Pssm-ID: 235252  Cd Length: 172  Bit Score: 40.21  E-value: 9.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696228051  47 IEAARIAITRYMKR-----GGKVWIKIFPQ------KSYTSKGV-----GVRMGNGKgaPEGWVAPTKRGTIMFEVGGVS 110
Cdd:PRK04199  62 LEAARIAANKYLTKtvgrsNYHLKIRVYPHhvlrenKMATGAGAdrvsdGMRLAFGK--PVGTAARVEKGQKIFTVRVNP 139
                         90       100
                 ....*....|....*....|....
gi 696228051 111 E--AVAKEALRLAMHKLPVKAKIV 132
Cdd:PRK04199 140 EhlEAAKEALRRAAMKLPTPCRIV 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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