NCBI Conserved Domain Search

Conserved domains on [gi|695721597]

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Chain A, Transketolase

Protein Classification

transketolase family protein( domain architecture ID 11414320)

transketolase family protein such as transketolase, which catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate

CATH: 3.40.50.970|3.40.50.920

EC: 2.2.1.-

Gene Ontology: GO:0016744

PubMed: 9924800

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

TktA

COG0021

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...

21-680

0e+00

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway

Pssm-ID: 439792 [Multi-domain] Cd Length: 661 Bit Score: 1203.29 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  21 DQVDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAG 100
Cdd:COG0021    1 MPLDQLAANAIRALAMDAVQKANSGHPGLPMGMAPIAYVLWTKFLKHNPA-NPKWPNRDRFVLSAGHGSMLLYSLLHLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 101 YDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLM 180
Cdd:COG0021   80 YDLSLDDLKNFRQLGSKTPGHPEYGHTPGVETTTGPLGQGIANAVGMAIAERHLAARFNRPGHDIVDHYTYVIAGDGDLM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 181 EGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPT 260
Cdd:COG0021  160 EGISHEAASLAGHLKLGKLIVLYDDNGISIDGDTDLAFSEDVAKRFEAYGWHVIRVEDGHDLEAIDAAIEAAKAETDKPT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 261 IIEIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLqDKGVKAENKWNEMFEAYKKE 339
Cdd:COG0021  240 LIICKTIIGYGSPNkQGTAKAHGAPLGAEEIAATKEALGWPPEPFEVPDEVYAHWRAAG-ERGAAAEAEWNERFAAYAAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 340 YSDLAQKFSDGFSNKVPNTLGDILPQYGEDD-SIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESY 418
Cdd:COG0021  319 YPELAAELERRLAGELPEDWDAALPAFEADAkGVATRKASGKVLNALAPVLPELIGGSADLAGSNKTTIKGAGSFSPEDP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 419 EGRNIWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLA 498
Cdd:COG0021  399 SGRNIHFGVREHAMGAIMNGIALHGGLRPYGGTFLVFSDYMRPAIRLAALMKLPVIYVFTHDSIGLGEDGPTHQPVEQLA 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 499 SLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVfDGVEKGGYVVQGAENEADGILIATGS 578
Cdd:COG0021  479 SLRAIPNLDVIRPADANETAAAWKLALERKDGPTALILSRQNLPTLDRTAAAA-EGVAKGAYVLADAEGTPDVILIATGS 557

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 579 EVGLALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSA 658
Cdd:COG0021  558 EVSLAVEAAELLAAEGIKVRVVSMPSWELFEAQDAAYRESVLPPAVRARVAVEAGVTDGWYKYVGLDGAVIGIDTFGASA 637

                        650       660
                 ....*....|....*....|..
gi 695721597 659 PSDIVLRELGMSVENIVDKYLE 680
Cdd:COG0021  638 PAKVLFEEFGFTVENVVAAAKE 659

Name

Accession

Description

Interval

E-value

TktA

COG0021

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...

21-680

0e+00

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway

Pssm-ID: 439792 [Multi-domain] Cd Length: 661 Bit Score: 1203.29 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  21 DQVDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAG 100
Cdd:COG0021    1 MPLDQLAANAIRALAMDAVQKANSGHPGLPMGMAPIAYVLWTKFLKHNPA-NPKWPNRDRFVLSAGHGSMLLYSLLHLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 101 YDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLM 180
Cdd:COG0021   80 YDLSLDDLKNFRQLGSKTPGHPEYGHTPGVETTTGPLGQGIANAVGMAIAERHLAARFNRPGHDIVDHYTYVIAGDGDLM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 181 EGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPT 260
Cdd:COG0021  160 EGISHEAASLAGHLKLGKLIVLYDDNGISIDGDTDLAFSEDVAKRFEAYGWHVIRVEDGHDLEAIDAAIEAAKAETDKPT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 261 IIEIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLqDKGVKAENKWNEMFEAYKKE 339
Cdd:COG0021  240 LIICKTIIGYGSPNkQGTAKAHGAPLGAEEIAATKEALGWPPEPFEVPDEVYAHWRAAG-ERGAAAEAEWNERFAAYAAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 340 YSDLAQKFSDGFSNKVPNTLGDILPQYGEDD-SIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESY 418
Cdd:COG0021  319 YPELAAELERRLAGELPEDWDAALPAFEADAkGVATRKASGKVLNALAPVLPELIGGSADLAGSNKTTIKGAGSFSPEDP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 419 EGRNIWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLA 498
Cdd:COG0021  399 SGRNIHFGVREHAMGAIMNGIALHGGLRPYGGTFLVFSDYMRPAIRLAALMKLPVIYVFTHDSIGLGEDGPTHQPVEQLA 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 499 SLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVfDGVEKGGYVVQGAENEADGILIATGS 578
Cdd:COG0021  479 SLRAIPNLDVIRPADANETAAAWKLALERKDGPTALILSRQNLPTLDRTAAAA-EGVAKGAYVLADAEGTPDVILIATGS 557

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 579 EVGLALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSA 658
Cdd:COG0021  558 EVSLAVEAAELLAAEGIKVRVVSMPSWELFEAQDAAYRESVLPPAVRARVAVEAGVTDGWYKYVGLDGAVIGIDTFGASA 637

                        650       660
                 ....*....|....*....|..
gi 695721597 659 PSDIVLRELGMSVENIVDKYLE 680
Cdd:COG0021  638 PAKVLFEEFGFTVENVVAAAKE 659

tktlase_bact

TIGR00232

transketolase, bacterial and yeast; This model is designed to capture orthologs of bacterial ...

28-677

0e+00

transketolase, bacterial and yeast; This model is designed to capture orthologs of bacterial transketolases. The group includes two from the yeast Saccharomyces cerevisiae but excludes dihydroxyactetone synthases (formaldehyde transketolases) from various yeasts and the even more distant mammalian transketolases. Among the family of thiamine diphosphate-dependent enzymes that includes transketolases, dihydroxyacetone synthases, pyruvate dehydrogenase E1-beta subunits, and deoxyxylulose-5-phosphate synthases, mammalian and bacterial transketolases seem not to be orthologous. [Energy metabolism, Pentose phosphate pathway]

Pssm-ID: 272974 [Multi-domain] Cd Length: 653 Bit Score: 933.36 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   28 VNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPkTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDVSMDD 107
Cdd:TIGR00232   4 ANAIRHLSMDAIQKAKSGHPGAPMGAAPIAEVLWTKFLKFNP-TNPKWINRDRFVLSNGHGSMLLYSLLHLTGYDLSIED 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  108 LKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEA 187
Cdd:TIGR00232  83 LKQFRQLHSKTPGHPEYGHTAGVEATTGPLGQGIANAVGMAIAEKTLAATFNKPGFEIVDHYTYVFVGDGCLQEGISYEV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  188 ASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTIIEIKTT 267
Cdd:TIGR00232 163 ASLAGHLKLGKLIVLYDSNRISIDGAVDGSFTEDVAKRFEAYGWEVLEVEDGHDLAAIDAAIEEAKASTDKPTLIEVKTT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  268 IGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLQDKGVKAENKWNEMFEAYKKEYSDLAQK 346
Cdd:TIGR00232 243 IGFGSPNkAGTHGVHGAPLGDEEVALTKKNLGWNYNPFEIPQEVYDHFKKTVKERGAKAEQEWNELFAAYKKKYPELAAE 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  347 FSDGFSNKVPNTLGDILPQY-GEDDSIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFqPESYEGRNIWF 425
Cdd:TIGR00232 323 FTRRLSGELPADWDKQLPEFkVKLQALATRKYSQNVLNAIANVLPELLGGSADLAPSNLTKWKGSGDL-HENPLGNYIHY 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  426 GVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPN 505
Cdd:TIGR00232 402 GVREFAMGAIMNGIALHGGFKPYGGTFLMFVDYARPAIRLAALMKLPVIYVYTHDSIGVGEDGPTHQPIEQLASLRAIPN 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  506 VQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPiskEKVFDGVEKGGYVVQGAENeADGILIATGSEVGLALK 585
Cdd:TIGR00232 482 LSVWRPCDGNETAAAWKYALESQDGPTALILSRQNLPQLE---ESSLEKVLKGGYVLKDSKG-PDLILIATGSEVQLAVE 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  586 AKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELkKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVLR 665
Cdd:TIGR00232 558 AAKKLAAENIKVRVVSMPSFDLFDKQDEEYRESVLPANV-TRLAIEAGAADEWYKYAGLVGAILGMDSFGESAPGDKLFE 636

                         650
                  ....*....|..
gi 695721597  666 ELGMSVENIVDK 677
Cdd:TIGR00232 637 EFGFTVENVVAK 648

PLN02790

transketolase

32-677

0e+00

transketolase

Pssm-ID: 215424 [Multi-domain] Cd Length: 654 Bit Score: 925.19 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  32 RTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKTHmNWVNRDRFVLSAGHGSALLYSLAHLAGYD-VSMDDLKN 110
Cdd:PLN02790   2 RFLAIDAVNKANSGHPGLPMGCAPMGHVLYDEVMKYNPKNP-YWFNRDRFVLSAGHGCMLQYALLHLAGYDsVQMEDLKQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 111 FREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEAASL 190
Cdd:PLN02790  81 FRQWGSRTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDHKIVDHYTYCILGDGCQMEGISNEAASL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 191 AGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFN-LEEIDKAIVQAKAESDKPTIIEIKTTIG 269
Cdd:PLN02790 161 AGHWGLGKLIVLYDDNHISIDGDTEIAFTEDVDKRYEALGWHTIWVKNGNTdYDEIRAAIKEAKAVTDKPTLIKVTTTIG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 270 YGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKEClQDKGVKAENKWNEMFEAYKKEYSDLAQKFS 348
Cdd:PLN02790 241 YGSPNkANSYSVHGAALGEKEVDATRKNLGWPYEPFHVPEDVKSHWSKH-TKEGAALEAEWNAKFAEYKKKYPEEAAELK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 349 DGFSNKVPNTLGDILPQYGEDDSI-ATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESYEGRNIWFGV 427
Cdd:PLN02790 320 SLISGELPSGWEKALPTFTPEDPAdATRNLSQKCLNALAKVLPGLIGGSADLASSNMTLLKDFGDFQKDTPEERNVRFGV 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 428 REFGMACAMNGIMLHG-GTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNV 506
Cdd:PLN02790 400 REHGMGAICNGIALHSsGLIPYCATFFVFTDYMRAAMRLSALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLASLRAMPNI 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 507 QVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKekvFDGVEKGGYVVQG--AENEADGILIATGSEVGLAL 584
Cdd:PLN02790 480 LMLRPADGNETAGAYKVAVTNRKRPTVLALSRQKVPNLPGTS---IEGVEKGGYVISDnsSGNKPDLILIGTGSELEIAA 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 585 KAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVL 664
Cdd:PLN02790 557 KAAKELRKEGKKVRVVSMVCWELFEEQSDEYKESVLPSSVTARVSVEAGSTFGWEKYVGSKGKVIGVDRFGASAPAGILY 636

                        650
                 ....*....|...
gi 695721597 665 RELGMSVENIVDK 677
Cdd:PLN02790 637 KEFGFTVENVVAA 649

Transketolase_N

pfam00456

Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...

23-356

5.21e-177

Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.

Pssm-ID: 395366 [Multi-domain] Cd Length: 334 Bit Score: 507.31 E-value: 5.21e-177

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   23 VDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPkTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYD 102
Cdd:pfam00456   1 IDKRAVNAIRALAMDAVEKANSGHPGAPMGMAPIAEVLFKRFLKHNP-NDPKWINRDRFVLSNGHGSMLLYSLLHLTGYD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  103 VSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEG 182
Cdd:pfam00456  80 LSMEDLKSFRQLGSKTPGHPEFGHTAGVEVTTGPLGQGIANAVGMAIAERNLAATYNRPGFDIVDHYTYVFLGDGCLMEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  183 VASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTII 262
Cdd:pfam00456 160 VSSEASSLAGHLGLGNLIVFYDDNQISIDGETKISFTEDTAARFEAYGWHVIEVEDGHDVEAIAAAIEEAKAEKDKPTLI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  263 EIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWN-YPPFTVPEEVSQRFKECLQDkGVKAENKWNEMFEAYKKEY 340
Cdd:pfam00456 240 KCRTVIGYGSPNkQGTHDVHGAPLGADEVAALKQKLGWDpYKPFEIPAEVYDAWKEKVAE-GAKAEAEWNELFAAYKKAY 318

                         330
                  ....*....|....*.
gi 695721597  341 SDLAQKFSDGFSNKVP 356
Cdd:pfam00456 319 PELAAEFARRLSGELP 334

TPP_TK

cd02012

Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...

29-294

3.11e-137

Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.

Pssm-ID: 238970 [Multi-domain] Cd Length: 255 Bit Score: 402.27 E-value: 3.11e-137

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  29 NTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDvSMDDL 108
Cdd:cd02012    1 NRIRRLSIDMVQKAGSGHPGGSLSAADILAVLYFKVLKYDPA-DPKWPNRDRFVLSKGHASPALYAVLALAGYL-PEEDL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 109 KNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKkfnregypvmDHYTYALIGDGDLMEGVASEAA 188
Cdd:cd02012   79 KTFRQLGSRLPGHPEYGLTPGVEVTTGSLGQGLSVAVGMALAEKLLGF----------DYRVYVLLGDGELQEGSVWEAA 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 189 SLAGHLKLGKLIALYDSNGISLDGKTSA-SFTENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKAESDKPTIIEIKTT 267
Cdd:cd02012  149 SFAGHYKLDNLIAIVDSNRIQIDGPTDDiLFTEDLAKKFEAFGWNVIEV-DGHDVEEILAALEEAKKSKGKPTLIIAKTI 227

                        250       260
                 ....*....|....*....|....*...
gi 695721597 268 IGYGSEN-QGTHKVHGSPLGEEGVAHAK 294
Cdd:cd02012  228 KGKGVPFmENTAKWHGKPLGEEEVELAK 255

Transket_pyr

smart00861

Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...

423-541

6.81e-34

Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.

Pssm-ID: 214865 [Multi-domain] Cd Length: 136 Bit Score: 126.06 E-value: 6.81e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   423 IWFGVREFGMACAMNGIMLHGGtRIFGSTFFVFSDYLKAAIRLSAIQKLpVIYVLTHDS-VAVGKDGPTHEPIEQLASLR 501
Cdd:smart00861  18 IDTGIAEQAMVGFAAGLALHGL-RPVVEIFFTFFDRAKDQIRSAGASGN-VPVVFRHDGgGGVGEDGPTHHSIEDEALLR 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 695721597   502 TIPNVQVFRPADGNETSAAWKVALEtLDKPTILVLSRQNL 541
Cdd:smart00861  96 AIPGLKVVAPSDPAEAKGLLRAAIR-DDGPVVIRLERKSL 134

Name

Accession

Description

Interval

E-value

TktA

COG0021

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...

21-680

0e+00

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway

Pssm-ID: 439792 [Multi-domain] Cd Length: 661 Bit Score: 1203.29 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  21 DQVDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAG 100
Cdd:COG0021    1 MPLDQLAANAIRALAMDAVQKANSGHPGLPMGMAPIAYVLWTKFLKHNPA-NPKWPNRDRFVLSAGHGSMLLYSLLHLTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 101 YDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLM 180
Cdd:COG0021   80 YDLSLDDLKNFRQLGSKTPGHPEYGHTPGVETTTGPLGQGIANAVGMAIAERHLAARFNRPGHDIVDHYTYVIAGDGDLM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 181 EGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPT 260
Cdd:COG0021  160 EGISHEAASLAGHLKLGKLIVLYDDNGISIDGDTDLAFSEDVAKRFEAYGWHVIRVEDGHDLEAIDAAIEAAKAETDKPT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 261 IIEIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLqDKGVKAENKWNEMFEAYKKE 339
Cdd:COG0021  240 LIICKTIIGYGSPNkQGTAKAHGAPLGAEEIAATKEALGWPPEPFEVPDEVYAHWRAAG-ERGAAAEAEWNERFAAYAAA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 340 YSDLAQKFSDGFSNKVPNTLGDILPQYGEDD-SIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESY 418
Cdd:COG0021  319 YPELAAELERRLAGELPEDWDAALPAFEADAkGVATRKASGKVLNALAPVLPELIGGSADLAGSNKTTIKGAGSFSPEDP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 419 EGRNIWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLA 498
Cdd:COG0021  399 SGRNIHFGVREHAMGAIMNGIALHGGLRPYGGTFLVFSDYMRPAIRLAALMKLPVIYVFTHDSIGLGEDGPTHQPVEQLA 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 499 SLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVfDGVEKGGYVVQGAENEADGILIATGS 578
Cdd:COG0021  479 SLRAIPNLDVIRPADANETAAAWKLALERKDGPTALILSRQNLPTLDRTAAAA-EGVAKGAYVLADAEGTPDVILIATGS 557

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 579 EVGLALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSA 658
Cdd:COG0021  558 EVSLAVEAAELLAAEGIKVRVVSMPSWELFEAQDAAYRESVLPPAVRARVAVEAGVTDGWYKYVGLDGAVIGIDTFGASA 637

                        650       660
                 ....*....|....*....|..
gi 695721597 659 PSDIVLRELGMSVENIVDKYLE 680
Cdd:COG0021  638 PAKVLFEEFGFTVENVVAAAKE 659

tktlase_bact

TIGR00232

transketolase, bacterial and yeast; This model is designed to capture orthologs of bacterial ...

28-677

0e+00

Pssm-ID: 272974 [Multi-domain] Cd Length: 653 Bit Score: 933.36 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   28 VNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPkTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDVSMDD 107
Cdd:TIGR00232   4 ANAIRHLSMDAIQKAKSGHPGAPMGAAPIAEVLWTKFLKFNP-TNPKWINRDRFVLSNGHGSMLLYSLLHLTGYDLSIED 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  108 LKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEA 187
Cdd:TIGR00232  83 LKQFRQLHSKTPGHPEYGHTAGVEATTGPLGQGIANAVGMAIAEKTLAATFNKPGFEIVDHYTYVFVGDGCLQEGISYEV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  188 ASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTIIEIKTT 267
Cdd:TIGR00232 163 ASLAGHLKLGKLIVLYDSNRISIDGAVDGSFTEDVAKRFEAYGWEVLEVEDGHDLAAIDAAIEEAKASTDKPTLIEVKTT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  268 IGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLQDKGVKAENKWNEMFEAYKKEYSDLAQK 346
Cdd:TIGR00232 243 IGFGSPNkAGTHGVHGAPLGDEEVALTKKNLGWNYNPFEIPQEVYDHFKKTVKERGAKAEQEWNELFAAYKKKYPELAAE 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  347 FSDGFSNKVPNTLGDILPQY-GEDDSIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFqPESYEGRNIWF 425
Cdd:TIGR00232 323 FTRRLSGELPADWDKQLPEFkVKLQALATRKYSQNVLNAIANVLPELLGGSADLAPSNLTKWKGSGDL-HENPLGNYIHY 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  426 GVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPN 505
Cdd:TIGR00232 402 GVREFAMGAIMNGIALHGGFKPYGGTFLMFVDYARPAIRLAALMKLPVIYVYTHDSIGVGEDGPTHQPIEQLASLRAIPN 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  506 VQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPiskEKVFDGVEKGGYVVQGAENeADGILIATGSEVGLALK 585
Cdd:TIGR00232 482 LSVWRPCDGNETAAAWKYALESQDGPTALILSRQNLPQLE---ESSLEKVLKGGYVLKDSKG-PDLILIATGSEVQLAVE 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  586 AKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELkKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVLR 665
Cdd:TIGR00232 558 AAKKLAAENIKVRVVSMPSFDLFDKQDEEYRESVLPANV-TRLAIEAGAADEWYKYAGLVGAILGMDSFGESAPGDKLFE 636

                         650
                  ....*....|..
gi 695721597  666 ELGMSVENIVDK 677
Cdd:TIGR00232 637 EFGFTVENVVAK 648

PLN02790

transketolase

32-677

0e+00

transketolase

Pssm-ID: 215424 [Multi-domain] Cd Length: 654 Bit Score: 925.19 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  32 RTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKTHmNWVNRDRFVLSAGHGSALLYSLAHLAGYD-VSMDDLKN 110
Cdd:PLN02790   2 RFLAIDAVNKANSGHPGLPMGCAPMGHVLYDEVMKYNPKNP-YWFNRDRFVLSAGHGCMLQYALLHLAGYDsVQMEDLKQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 111 FREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEAASL 190
Cdd:PLN02790  81 FRQWGSRTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDHKIVDHYTYCILGDGCQMEGISNEAASL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 191 AGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFN-LEEIDKAIVQAKAESDKPTIIEIKTTIG 269
Cdd:PLN02790 161 AGHWGLGKLIVLYDDNHISIDGDTEIAFTEDVDKRYEALGWHTIWVKNGNTdYDEIRAAIKEAKAVTDKPTLIKVTTTIG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 270 YGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKEClQDKGVKAENKWNEMFEAYKKEYSDLAQKFS 348
Cdd:PLN02790 241 YGSPNkANSYSVHGAALGEKEVDATRKNLGWPYEPFHVPEDVKSHWSKH-TKEGAALEAEWNAKFAEYKKKYPEEAAELK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 349 DGFSNKVPNTLGDILPQYGEDDSI-ATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESYEGRNIWFGV 427
Cdd:PLN02790 320 SLISGELPSGWEKALPTFTPEDPAdATRNLSQKCLNALAKVLPGLIGGSADLASSNMTLLKDFGDFQKDTPEERNVRFGV 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 428 REFGMACAMNGIMLHG-GTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNV 506
Cdd:PLN02790 400 REHGMGAICNGIALHSsGLIPYCATFFVFTDYMRAAMRLSALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLASLRAMPNI 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 507 QVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKekvFDGVEKGGYVVQG--AENEADGILIATGSEVGLAL 584
Cdd:PLN02790 480 LMLRPADGNETAGAYKVAVTNRKRPTVLALSRQKVPNLPGTS---IEGVEKGGYVISDnsSGNKPDLILIGTGSELEIAA 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 585 KAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVL 664
Cdd:PLN02790 557 KAAKELRKEGKKVRVVSMVCWELFEEQSDEYKESVLPSSVTARVSVEAGSTFGWEKYVGSKGKVIGVDRFGASAPAGILY 636

                        650
                 ....*....|...
gi 695721597 665 RELGMSVENIVDK 677
Cdd:PLN02790 637 KEFGFTVENVVAA 649

PRK05899

transketolase; Reviewed

24-680

0e+00

transketolase; Reviewed

Pssm-ID: 235639 [Multi-domain] Cd Length: 586 Bit Score: 919.91 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  24 DQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDV 103
Cdd:PRK05899   8 LQLLANAIRVLSIDAVQKANSGHPGMPMGAADIAYVLWTRFLRHDPK-NPKWPNRDRFVLSAGHGSMLLYSLLHLAGYDL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 104 SMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGV 183
Cdd:PRK05899  87 SIDDLKNFRQLGSKTPGHPEYGHTPGVETTTGPLGQGLANAVGMALAEKYLAALFNRPGLDIVDHYTYVLCGDGDLMEGI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 184 ASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKAeSDKPTIIE 263
Cdd:PRK05899 167 SHEACSLAGHLKLGNLIVIYDDNRISIDGPTEGWFTEDVKKRFEAYGWHVIEV-DGHDVEAIDAAIEEAKA-STKPTLII 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 264 IKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWNYppftvpeevsqrfkeclqdkgvkaenkwnemfeaykkeysd 342
Cdd:PRK05899 245 AKTIIGKGAPNkEGTHKVHGAPLGAEEIAAAKKELGWDY----------------------------------------- 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 343 laqkfsdgfsnkvpntlgdilpqygeddsiatRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESYEGRN 422
Cdd:PRK05899 284 --------------------------------RKASGKALNALAKALPELVGGSADLAGSNNTKIKGSKDFAPEDYSGRY 331

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 423 IWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRT 502
Cdd:PRK05899 332 IHYGVREFAMAAIANGLALHGGFIPFGGTFLVFSDYARNAIRLAALMKLPVIYVFTHDSIGVGEDGPTHQPVEQLASLRA 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 503 IPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPisKEKVFDGVEKGGYVVqgaENEADGILIATGSEVGL 582
Cdd:PRK05899 412 IPNLTVIRPADANETAAAWKYALERKDGPSALVLTRQNLPVLE--RTAQEEGVAKGGYVL---RDDPDVILIATGSEVHL 486

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 583 ALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDI 662
Cdd:PRK05899 487 ALEAADELEAEGIKVRVVSMPSTELFDEQDAAYKESVLPAAVTARVAVEAGVADGWYKYVGLDGKVLGIDTFGASAPADE 566

                        650
                 ....*....|....*...
gi 695721597 663 VLRELGMSVENIVDKYLE 680
Cdd:PRK05899 567 LFKEFGFTVENIVAAAKE 584

PTZ00089

transketolase; Provisional

21-677

0e+00

transketolase; Provisional

Pssm-ID: 173383 [Multi-domain] Cd Length: 661 Bit Score: 847.04 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  21 DQVDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAG 100
Cdd:PTZ00089   3 GAIDEKCANEIRCLSADLVQKANSGHPGAPMGMAPIAHILWSEVMKYNPK-DPRWINRDRFVLSNGHASALLYSMLHLTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 101 YDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLM 180
Cdd:PTZ00089  82 YDLSMEDLKNFRQLGSRTPGHPERHITPGVEVTTGPLGQGIANAVGLAIAEKHLAAKFNRPGHPIFDNYVYVICGDGCLQ 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 181 EGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDG-FNLEEIDKAIVQAKAESDKP 259
Cdd:PTZ00089 162 EGVSQEALSLAGHLGLEKLIVLYDDNKITIDGNTDLSFTEDVEKKYEAYGWHVIEVDNGnTDFDGLRKAIEEAKKSKGKP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 260 TIIEIKTTIGYGSENQGTHKVHGSPLGEEGVAHAKEVYNWNypP---FTVPEEVSQRFKEcLQDKGVKAENKWNEMFEAY 336
Cdd:PTZ00089 242 KLIIVKTTIGYGSSKAGTEKVHGAPLGDEDIAQVKELFGLD--PekkFHVSEEVRQFFEQ-HVEKKKENYEAWKKRFAKY 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 337 KKEYSDLAQKFSDGFSNKVPNTLGDILPQYGEDDS-IATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQP 415
Cdd:PTZ00089 319 TAAFPKEAQAIERRFKGELPPGWEKKLPKYTTNDKaIATRKASENVLNPLFQILPELIGGSADLTPSNLTRPKEANDFTK 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 416 ESYEGRNIWFGVREFGMACAMNGIMLHGGTRIFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIE 495
Cdd:PTZ00089 399 ASPEGRYIRFGVREHAMCAIMNGIAAHGGFIPFGATFLNFYGYALGAVRLAALSHHPVIYVATHDSIGLGEDGPTHQPVE 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 496 QLASLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKekvFDGVEKGGYVVQGAENEADGILIA 575
Cdd:PTZ00089 479 TLALLRATPNLLVIRPADGTETSGAYALALANAKTPTILCLSRQNTPPLPGSS---IEGVLKGAYIVVDFTNSPQLILVA 555

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 576 TGSEVGLALKAKEELqKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHgvmIGIDEFG 655
Cdd:PTZ00089 556 SGSEVSLCVEAAKAL-SKELNVRVVSMPCWELFDQQSEEYQQSVLPSGGVPVLSVEAYVSFGWEKYSHVH---VGISGFG 631

                        650       660
                 ....*....|....*....|..
gi 695721597 656 MSAPSDIVLRELGMSVENIVDK 677
Cdd:PTZ00089 632 ASAPANALYKHFGFTVENVVEK 653

Transketolase_N

pfam00456

Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...

23-356

5.21e-177

Pssm-ID: 395366 [Multi-domain] Cd Length: 334 Bit Score: 507.31 E-value: 5.21e-177

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   23 VDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPkTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYD 102
Cdd:pfam00456   1 IDKRAVNAIRALAMDAVEKANSGHPGAPMGMAPIAEVLFKRFLKHNP-NDPKWINRDRFVLSNGHGSMLLYSLLHLTGYD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  103 VSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEG 182
Cdd:pfam00456  80 LSMEDLKSFRQLGSKTPGHPEFGHTAGVEVTTGPLGQGIANAVGMAIAERNLAATYNRPGFDIVDHYTYVFLGDGCLMEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  183 VASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTII 262
Cdd:pfam00456 160 VSSEASSLAGHLGLGNLIVFYDDNQISIDGETKISFTEDTAARFEAYGWHVIEVEDGHDVEAIAAAIEEAKAEKDKPTLI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  263 EIKTTIGYGSEN-QGTHKVHGSPLGEEGVAHAKEVYNWN-YPPFTVPEEVSQRFKECLQDkGVKAENKWNEMFEAYKKEY 340
Cdd:pfam00456 240 KCRTVIGYGSPNkQGTHDVHGAPLGADEVAALKQKLGWDpYKPFEIPAEVYDAWKEKVAE-GAKAEAEWNELFAAYKKAY 318

                         330
                  ....*....|....*.
gi 695721597  341 SDLAQKFSDGFSNKVP 356
Cdd:pfam00456 319 PELAAEFARRLSGELP 334

TPP_TK

cd02012

Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...

29-294

3.11e-137

Pssm-ID: 238970 [Multi-domain] Cd Length: 255 Bit Score: 402.27 E-value: 3.11e-137

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  29 NTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDvSMDDL 108
Cdd:cd02012    1 NRIRRLSIDMVQKAGSGHPGGSLSAADILAVLYFKVLKYDPA-DPKWPNRDRFVLSKGHASPALYAVLALAGYL-PEEDL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 109 KNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKkfnregypvmDHYTYALIGDGDLMEGVASEAA 188
Cdd:cd02012   79 KTFRQLGSRLPGHPEYGLTPGVEVTTGSLGQGLSVAVGMALAEKLLGF----------DYRVYVLLGDGELQEGSVWEAA 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 189 SLAGHLKLGKLIALYDSNGISLDGKTSA-SFTENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKAESDKPTIIEIKTT 267
Cdd:cd02012  149 SFAGHYKLDNLIAIVDSNRIQIDGPTDDiLFTEDLAKKFEAFGWNVIEV-DGHDVEEILAALEEAKKSKGKPTLIIAKTI 227

                        250       260
                 ....*....|....*....|....*...
gi 695721597 268 IGYGSEN-QGTHKVHGSPLGEEGVAHAK 294
Cdd:cd02012  228 KGKGVPFmENTAKWHGKPLGEEEVELAK 255

TktA1

COG3959

Transketolase, N-terminal subunit [Carbohydrate transport and metabolism];

31-288

1.31e-66

Transketolase, N-terminal subunit [Carbohydrate transport and metabolism];

Pssm-ID: 443159 [Multi-domain] Cd Length: 277 Bit Score: 220.33 E-value: 1.31e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  31 LRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKtHMNWVNRDRFVLSAGHGSALLYS-LAHlAGYdVSMDDLK 109
Cdd:COG3959   15 IRRDILRMIYAAGSGHPGGSLSAADILAALYFKVMNIDPK-NPDWPDRDRFILSKGHAAPALYAvLAE-KGY-FPKEELA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 110 NFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAmaeahLGKKFNREgypvmDHYTYALIGDGDLMEGVASEAAS 189
Cdd:COG3959   92 TFRKLGSRLQGHPDMKKTPGVEMSTGSLGQGLSVAVGMA-----LAAKLDGK-----DYRVYVLLGDGELQEGQVWEAAM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 190 LAGHLKLGKLIALYDSNGISLDGKTSASF-TENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKAESDKPTIIEIKTTI 268
Cdd:COG3959  162 AAAHYKLDNLIAIVDRNGLQIDGPTEDVMsLEPLAEKWEAFGWHVIEV-DGHDIEALLAALDEAKAVKGKPTVIIAHTVK 240

                        250       260
                 ....*....|....*....|.
gi 695721597 269 GYG-SENQGTHKVHGSPLGEE 288
Cdd:COG3959  241 GKGvSFMENRPKWHGKAPNDE 261

Transket_pyr

pfam02779

Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...

370-541

4.10e-60

Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.

Pssm-ID: 460692 [Multi-domain] Cd Length: 174 Bit Score: 199.31 E-value: 4.10e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  370 DSIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPEsyeGRNIWFGVREFGMACAMNGIMLHGG-TRIF 448
Cdd:pfam02779   1 KKIATRKASGEALAELAKRDPRVVGGGADLAGGTFTVTKGLLHPQGA---GRVIDTGIAEQAMVGFANGMALHGPlLPPV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  449 GSTFFVFSDYLKAAIR-LSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALET 527
Cdd:pfam02779  78 EATFSDFLNRADDAIRhGAALGKLPVPFVVTRDPIGVGEDGPTHQSVEDLAFLRAIPGLKVVRPSDAAETKGLLRAAIRR 157

                         170
                  ....*....|....*
gi 695721597  528 LD-KPTILVLSRQNL 541
Cdd:pfam02779 158 DGrKPVVLRLPRQLL 172

TPP_PYR_DXS_TK_like

cd07033

Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), ...

376-538

5.04e-60

Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and the beta subunits of the E1 component of the human pyruvate dehydrogenase complex (E1- PDHc), subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Like many TPP-dependent enzymes DXS and TK are homodimers having a PYR and a PP domain on the same subunit. TK has two active sites per dimer which lie between PYR and PP domains of different subunits. For DXS each active site is located at the interface of a PYR and a PP domain from the same subunit. E1-PDHc is an alpha2beta2 dimer-of-heterodimers having two active sites but having the PYR and PP domains arranged on separate subunits, the PYR domains on the beta subunits, the PP domains on the alpha subunits. DXS is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis, it catalyzes a transketolase-type condensation of pyruvate with D-glyceraldehyde-3-phosphate to form 1-deoxy-D-xylulose-5-phosphate (DXP) and carbon dioxide. TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. TK also plays a central role in the Calvin cycle in plants. PDHc catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. This subfamily includes the beta subunits of the E1 component of the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). ADC participates in the breakdown of acetoin. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate during the breakdown of branched chain amino acids.

Pssm-ID: 132916 [Multi-domain] Cd Length: 156 Bit Score: 198.43 E-value: 5.04e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 376 AASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGdfqpesYEGRNIWFGVREFGMACAMNGIMLHGgTRIFGSTFFVF 455
Cdd:cd07033    1 KAFGEALLELAKKDPRIVALSADLGGSTGLDKFAKK------FPDRFIDVGIAEQNMVGIAAGLALHG-LKPFVSTFSFF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 456 SDYLKAAIR-LSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALETlDKPTIL 534
Cdd:cd07033   74 LQRAYDQIRhDVALQNLPVKFVGTHAGISVGEDGPTHQGIEDIALLRAIPNMTVLRPADANETAAALEAALEY-DGPVYI 152


                 ....
gi 695721597 535 VLSR 538
Cdd:cd07033  153 RLPR 156

Transket_pyr

smart00861

Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...

423-541

6.81e-34

Pssm-ID: 214865 [Multi-domain] Cd Length: 136 Bit Score: 126.06 E-value: 6.81e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   423 IWFGVREFGMACAMNGIMLHGGtRIFGSTFFVFSDYLKAAIRLSAIQKLpVIYVLTHDS-VAVGKDGPTHEPIEQLASLR 501
Cdd:smart00861  18 IDTGIAEQAMVGFAAGLALHGL-RPVVEIFFTFFDRAKDQIRSAGASGN-VPVVFRHDGgGGVGEDGPTHHSIEDEALLR 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 695721597   502 TIPNVQVFRPADGNETSAAWKVALEtLDKPTILVLSRQNL 541
Cdd:smart00861  96 AIPGLKVVAPSDPAEAKGLLRAAIR-DDGPVVIRLERKSL 134

TktA2

COG3958

Transketolase, C-terminal subunit [Carbohydrate transport and metabolism];

370-677

3.39e-29

Transketolase, C-terminal subunit [Carbohydrate transport and metabolism];

Pssm-ID: 443158 [Multi-domain] Cd Length: 308 Bit Score: 118.27 E-value: 3.39e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 370 DSIATRAASQKAINALAKEVSSLWGGAADLASSNKTviageGDFQpESYEGRNIWFGVRE---FGMACAMNgimlHGGTR 446
Cdd:COG3958    2 EKKAMRDAFGEALVELAEEDPDIVVLDADLGGSTKL-----DKFA-KAFPDRFFNVGIAEqnmVGVAAGLA----LAGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 447 IFGSTFFVFSdYLKAA--IRLS-AIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKV 523
Cdd:COG3958   72 PFVSTFAPFL-TGRAYeqIRNDiAYPNLNVKIVGSHAGLSYGEDGATHQALEDIALMRALPNMTVIVPADAVETEAAVRA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 524 ALETlDKPTILVLSRQNLdtlpiskEKVFDGVEK----GGYVV-QGaeneADGILIATGSEVGLALKAKEELQKKGKDVI 598
Cdd:COG3958  151 AAEH-DGPVYLRLGRGAV-------PVVYDEDYEfeigKARVLrEG----KDVTIIATGIMVAEALEAAELLAKEGISAR 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 599 VVSLPS-----WERFEAQSEEYKNTVippelkkrmTIEAGTTYG-----WAKYAGDHG----VMIGI-DEFGMSAPSDIV 663
Cdd:COG3958  219 VINMHTikpldEEAILKAARKTGAVV---------TAEEHSIIGglgsaVAEVLAENYpvplRRIGVpDRFGESGSPEEL 289

                        330
                 ....*....|....
gi 695721597 664 LRELGMSVENIVDK 677
Cdd:COG3958  290 LEKYGLDAEGIVAA 303

dxs

TIGR00204

1-deoxy-D-xylulose-5-phosphate synthase; DXP synthase is a thiamine diphosphate-dependent ...

19-679

6.16e-19

1-deoxy-D-xylulose-5-phosphate synthase; DXP synthase is a thiamine diphosphate-dependent enzyme related to transketolase and the pyruvate dehydrogenase E1-beta subunit. By an acyloin condensation of pyruvate with glyceraldehyde 3-phosphate, it produces 1-deoxy-D-xylulose 5-phosphate, a precursor of thiamine diphosphate (TPP), pyridoxal phosphate, and the isoprenoid building block isopentenyl diphosphate (IPP). [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine, Biosynthesis of cofactors, prosthetic groups, and carriers, Thiamine]

Pssm-ID: 129308 [Multi-domain] Cd Length: 617 Bit Score: 90.99 E-value: 6.16e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   19 PYDQVDQLgVNTLRTLSIDAIQrANSGHPGLPMGAAPMAYVLwtrHLKIN-PKthmnwvnrDRFVLSAGHGSallYSLAH 97
Cdd:TIGR00204  14 SIDELEKL-CDELRRYLLESVS-ASGGHLASGLGTVELTVAL---HYVFNtPK--------DQFIWDVGHQA---YPHKL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597   98 LAGYDVSMDDLKNFRewksNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAeahlgkkFNREGypvMDHYTYALIGDG 177
Cdd:TIGR00204  78 LTGRREKFSTLRQKK----GLHGFPKRSESEYDVFSAGHSSTSISAGLGIAVA-------AEKKG---ADRKTVCVIGDG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  178 DLMEGVASEAASLAGHLKLGKLIALYDSN-GIS-------------LDGKTSASFTENV--------------------- 222
Cdd:TIGR00204 144 AITAGMAFEALNHAGDLKTDMIVILNDNEmSISenvgalsnhlaqlRSGSLYQSLRDGLkkifsklppiknylakrtees 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  223 -------GARFEAYGWQYILVEDGFNLEEIDKAIVQAKaESDKPTIIEIKTTIGYGSEnqgthKVHGSPLGEEGVahake 295
Cdd:TIGR00204 224 mkglvvpGTFFEELGFNYIGPVDGHDLLELIETLKNAK-KLKGPVFLHIQTKKGKGYK-----PAEKDPIGWHGV----- 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  296 vynwnyPPFTVpeevsqrfkeclqDKGVKAENKwnEMFEAYKKEYSDLAQKfsdgfsnkvpntlgdilpqygeddsiatr 375
Cdd:TIGR00204 293 ------GPFDL-------------STGCLPKSK--SALPSYSKIFSDTLCE----------------------------- 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  376 aasqkainaLAKEVSSLWGGAADLASSNKTViagegDFQPEsyegrniwFGVREFGMACA------MNGIMLHGGTRIFG 449
Cdd:TIGR00204 323 ---------LAKKDNKIVGITPAMPEGSGLD-----KFSRK--------FPDRYFDVAIAeqhavtFAAGMAIEGYKPFV 380

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  450 StffVFSDYLKAA----IRLSAIQKLPVIYVLTHDSVaVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVAL 525
Cdd:TIGR00204 381 A---IYSTFLQRAydqvVHDVCIQKLPVLFAIDRAGI-VGADGETHQGAFDISYLRCIPNMVIMAPSDENELRQMLYTGY 456

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  526 ETLDKPTILVLSRQN---------LDTLPISKEKVfdgVEKGGyvvqgaeneaDGILIATGSEVGLALKAKEELQKKGKD 596
Cdd:TIGR00204 457 HYDDGPIAVRYPRGNavgveltpePEKLPIGKSEV---LRKGE----------KILILGFGTLVPEALEVAESLNEKGIE 523

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  597 VIVVSLpsweRFEAQSEEYKNTVIPPELKKRMTIEAGTTYGW-----AKYAGDHGVM-----IGI-DEFGMSAPSDIVLR 665
Cdd:TIGR00204 524 ATVVDA----RFVKPLDEELILEIAASHEKLVTVEENAIMGGagsavLEFLMDQNKLvpvkrLGIpDFFIPHGTQEEVLA 599

                         730
                  ....*....|....
gi 695721597  666 ELGMSVENIVDKYL 679
Cdd:TIGR00204 600 ELGLDTAGMEAKIL 613

PRK05444

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

141-677

7.13e-17

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

Pssm-ID: 235470 [Multi-domain] Cd Length: 580 Bit Score: 84.36 E-value: 7.13e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 141 ISMAVGMAMAEAHLGKKfnregypvmDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDsNGISLDgktsasftE 220
Cdd:PRK05444 123 ISAALGMAKARDLKGGE---------DRKVVAVIGDGALTGGMAFEALNNAGDLKSDLIVILND-NEMSIS--------P 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 221 NVGA--------R----FEAYGWQYILVEDGFNLEEIDKAIVQAKaESDKPTIIEIKTTIGYG---SENQGThKVHGSpl 285
Cdd:PRK05444 185 NVGAlsnylarlRsstlFEELGFNYIGPIDGHDLDALIETLKNAK-DLKGPVLLHVVTKKGKGyapAEADPI-KYHGV-- 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 286 geegvahakevynwnyPPFTVpeevsqrfkeclqDKGVKaenkwnemfeayKKEYSDLAQKFSDGFSnkvpNTLGDILpq 365
Cdd:PRK05444 261 ----------------GKFDP-------------ETGEQ------------PKSSKPGKPSYTKVFG----ETLCELA-- 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 366 yGEDDSIAtraasqkAINALAKEVSSLwggaadlassnktviageGDFQ---PESYegrniwF--GVRE-----F--GMA 433
Cdd:PRK05444 294 -EKDPKIV-------AITAAMPEGTGL------------------VKFSkrfPDRY------FdvGIAEqhavtFaaGLA 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 434 CamngimlhGGTRIFG---STFF------VFSDYlkaairlsAIQKLPVIYVLthDSvA--VGKDGPTHEPIEQLASLRT 502
Cdd:PRK05444 342 T--------EGLKPVVaiySTFLqraydqVIHDV--------ALQNLPVTFAI--DR-AglVGADGPTHQGAFDLSYLRC 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 503 IPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVFDgVEKGGYVVQGaeneADGILIATGSEVGL 582
Cdd:PRK05444 403 IPNMVIMAPSDENELRQMLYTALAYDDGPIAIRYPRGNGVGVELPELEPLP-IGKGEVLREG----EDVAILAFGTMLAE 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 583 ALKAKEELqkkgKDVIVVSLpsweRF---------EAQSEEYKNTVippelkkrmTIEAGTTYGWA-----KYAGDHGVM 648
Cdd:PRK05444 478 ALKAAERL----ASATVVDA----RFvkpldeellLELAAKHDLVV---------TVEEGAIMGGFgsavlEFLADHGLD 540

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 695721597 649 -----IGI-DEFGMSAPSDIVLRELGMSVENIVDK 677
Cdd:PRK05444 541 vpvlnLGLpDEFIDHGSREELLAELGLDAEGIARR 575

Dxs

COG1154

Deoxyxylulose-5-phosphate synthase [Coenzyme transport and metabolism, Lipid transport and ...

467-680

1.96e-15

Deoxyxylulose-5-phosphate synthase [Coenzyme transport and metabolism, Lipid transport and metabolism]; Deoxyxylulose-5-phosphate synthase is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis

Pssm-ID: 440768 [Multi-domain] Cd Length: 623 Bit Score: 80.06 E-value: 1.96e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 467 AIQKLPVIYVLthDSvA--VGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALEtLDKPTIL---------V 535
Cdd:COG1154  406 ALQNLPVTFAI--DR-AglVGADGPTHHGVFDLSYLRCIPNMVIMAPKDENELRHMLYTALA-YDGPTAIryprgngpgV 481

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 536 LSRQNLDTLPISK-EKVFDGvekggyvvqgaeneADGILIATGSEVGLALKAKEELQKKGKDVIVVSLpsweRFeaqsee 614
Cdd:COG1154  482 ELPAELEPLPIGKgEVLREG--------------KDVAILAFGTMVAEALEAAERLAAEGISATVVDA----RF------ 537

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 615 ykntVIP--PELKKRM--------TIEAGTT---YGWA--KYAGDHGV-----MIGI-DEFGMSAPSDIVLRELGMSVEN 673
Cdd:COG1154  538 ----VKPldEELILELarehdlvvTVEEGVLaggFGSAvlEFLADAGLdvpvlRLGLpDRFIEHGSRAELLAELGLDAEG 613


                 ....*..
gi 695721597 674 IVDKYLE 680
Cdd:COG1154  614 IARAILE 620

TPP_DXS

cd02007

Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; ...

133-271

6.19e-15

Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS catalyzes a transketolase-type condensation of pyruvate with D-glyceraldehyde-3-phosphate to form 1-deoxy-D-xylulose-5-phosphate (DXP) and carbon dioxide. The formation of DXP leads to the formation of the terpene precursor IPP (isopentyl diphosphate) and to the formation of thiamine (vitamin B1) and pyridoxal (vitamin B6).

Pssm-ID: 238965 [Multi-domain] Cd Length: 195 Bit Score: 73.73 E-value: 6.19e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 133 TTGPLGQGISMAVGMAMAEAHLGKKFNregypvmdhyTYALIGDGDLMEGVASEAASLAGHLKlGKLIALYDSNGISLDg 212
Cdd:cd02007   73 GTGHSSTSISAALGMAVARDLKGKKRK----------VIAVIGDGALTGGMAFEALNNAGYLK-SNMIVILNDNEMSIS- 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695721597 213 ktsasftENVGAR---FEAYGWQYILVEDGFNLEEIDKAIVQAKaESDKPTIIEIKTTIGYG 271
Cdd:cd02007  141 -------PNVGTPgnlFEELGFRYIGPVDGHNIEALIKVLKEVK-DLKGPVLLHVVTKKGKG 194

PRK12571

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

141-676

7.63e-14

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

Pssm-ID: 183601 [Multi-domain] Cd Length: 641 Bit Score: 74.76 E-value: 7.63e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 141 ISMAVGMAMAEAhLGKKfnregypvmDHYTYALIGDGDLMEGVASEAASLAGHLKlGKLIALYDSNGISLDGKTSA---- 216
Cdd:PRK12571 125 ISAALGFAKARA-LGQP---------DGDVVAVIGDGSLTAGMAYEALNNAGAAD-RRLIVILNDNEMSIAPPVGAlaay 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 217 --------------SFTENVGAR-------------------------FEAYGWQYILVEDGFNLEEIDKAIVQAKAESD 257
Cdd:PRK12571 194 lstlrssdpfarlrAIAKGVEERlpgplrdgarrarelvtgmigggtlFEELGFTYVGPIDGHDMEALLSVLRAARARAD 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 258 KPTIIEIKTTIGYGsenqgthkvhgsplgeegvahakevynwnYPPftvpeevsqrfKECLQDKgvkaenkwnemFEAYK 337
Cdd:PRK12571 274 GPVLVHVVTEKGRG-----------------------------YAP-----------AEADEDK-----------YHAVG 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 338 KeysdlaqkfsdgfsnkvpntlgdILPQYGEDDSIATRAAS-----QKAINALAKEVSSLWGGAADLASSnktviAGEGD 412
Cdd:PRK12571 303 K-----------------------FDVVTGLQKKSAPSAPSytsvfGEELTKEAAEDSDIVAITAAMPLG-----TGLDK 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 413 FQpESYEGRNIWFGVRE-FGMACAMNgiMLHGGTRIFgstFFVFSDYLKAA----IRLSAIQKLPVIYVLTHDSVaVGKD 487
Cdd:PRK12571 355 LQ-KRFPNRVFDVGIAEqHAVTFAAG--LAAAGLKPF---CAVYSTFLQRGydqlLHDVALQNLPVRFVLDRAGL-VGAD 427

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 488 GPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVFDGVEKGGYVVQGaen 567
Cdd:PRK12571 428 GATHAGAFDLAFLTNLPNMTVMAPRDEAELRHMLRTAAAHDDGPIAVRFPRGEGVGVEIPAEGTILGIGKGRVPREG--- 504

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 568 eADGILIATGSEVGLALKAKEELQKKGKDVIVVSlPSW-----ERFEAQSEEYKNTVIppelkkrmTIEAGTTYGW---- 638
Cdd:PRK12571 505 -PDVAILSVGAHLHECLDAADLLEAEGISVTVAD-PRFvkpldEALTDLLVRHHIVVI--------VEEQGAMGGFgahv 574

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*..
gi 695721597 639 AKYAGDHGVM--------IGI-DEFGMSAPSDIVLRELGMSVENIVD 676
Cdd:PRK12571 575 LHHLADTGLLdgglklrtLGLpDRFIDHASREEMYAEAGLTAPDIAA 621

Transketolase_C

pfam02780

Transketolase, C-terminal domain; The C-terminal domain of transketolase has been proposed as ...

559-674

1.14e-13

Transketolase, C-terminal domain; The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site.

Pssm-ID: 460693 [Multi-domain] Cd Length: 124 Bit Score: 68.01 E-value: 1.14e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  559 GYVVQGAENEaDGILIATGSEVGLALKAKEELQKKGKDVIVVSLPSWERFEAQS-----EEYKNTVIPPELKKRMTIEAG 633
Cdd:pfam02780   1 GKAEILREGD-DVTIVAYGSMVEEALEAAELLAKEGISAEVVDLRTIKPLDKETilesvKKTGRLVTVEEAVPRGGFGSE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 695721597  634 TTYGWAKYAGDHG----VMIGIDEFGMSAPSDIVLRELGMSVENI 674
Cdd:pfam02780  80 VAAALAEEAFDGLdapvLRVGGPDFPEPGSADELEKLYGLTPEKI 124

TPP_enzymes

cd00568

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...

121-266

1.64e-12

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.

Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 66.12 E-value: 1.64e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 121 HPEYGCTDGVEATTGPLGQGISMAVGMAMAEAhlgkkfnregypvmDHYTYALIGDGDLMEGVAsEAASlAGHLKLgKLI 200
Cdd:cd00568   32 PLRRGRRFLTSTGFGAMGYGLPAAIGAALAAP--------------DRPVVCIAGDGGFMMTGQ-ELAT-AVRYGL-PVI 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695721597 201 ALYDSNGISLDGKTSAS------------FTENVGARFEAYGWQYILVEDgfnLEEIDKAIVQAKAeSDKPTIIEIKT 266
Cdd:cd00568   95 VVVFNNGGYGTIRMHQEafyggrvsgtdlSNPDFAALAEAYGAKGVRVED---PEDLEAALAEALA-AGGPALIEVKT 168

PRK12315

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

141-676

1.49e-10

1-deoxy-D-xylulose-5-phosphate synthase; Provisional

Pssm-ID: 237053 [Multi-domain] Cd Length: 581 Bit Score: 64.26 E-value: 1.49e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 141 ISMAVGMAMAEAHLGKKFNregypVMdhytyALIGDGDLMEGVASEAASLAGHLKlGKLIALYDSNGISLD--------- 211
Cdd:PRK12315 119 IALATGLAKARDLKGEKGN-----II-----AVIGDGSLSGGLALEGLNNAAELK-SNLIIIVNDNQMSIAenhgglykn 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 212 --------GKTSASFtenvgarFEAYGWQYILVEDGFNLEEIDKAIVQAKaESDKPTIIEIKTTIGYGSEnqgthkvhgs 283
Cdd:PRK12315 188 lkelrdtnGQSENNL-------FKAMGLDYRYVEDGNDIESLIEAFKEVK-DIDHPIVLHIHTLKGKGYQ---------- 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 284 PLGEEgvahaKEVYNWNYpPFTVpeevsqrfkECLQDKgvkaenkwnemFEAYKKEYSDLAQKFsdgfsnkvpntlgdIL 363
Cdd:PRK12315 250 PAEEN-----KEAFHWHM-PFDL---------ETGQSK-----------VPASGESYSSVTLDY--------------LL 289

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 364 PQYGEDDSIAtraasqkAINAlakevsslwggaadlasSNKTVIaGEGDFQPEsYEGRNIWFGVREfGMACAMNGIMLHG 443
Cdd:PRK12315 290 KKIKEGKPVV-------AINA-----------------AIPGVF-GLKEFRKK-YPDQYVDVGIAE-QESVAFASGIAAN 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 444 GTRIFgstFFVFSDYLKAAI-RLS---AIQKLPVIYVLTHDSVAvGKDgPTHEPIEQLASLRTIPNVQVFRPADGNETSA 519
Cdd:PRK12315 343 GARPV---IFVNSTFLQRAYdQLShdlAINNNPAVMIVFGGSIS-GND-VTHLGIFDIPMISNIPNLVYLAPTTKEELIA 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 520 AWKVALETLDKPtilVLSRQNLDTLPISKEKVFDGVEKGGYVVQGAENEAdgiLIATGSEVGLALKAKEELQKK-GKDVI 598
Cdd:PRK12315 418 MLEWALTQHEHP---VAIRVPEHGVESGPTVDTDYSTLKYEVTKAGEKVA---ILALGDFYELGEKVAKKLKEElGIDAT 491

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 599 VV-----SLPSWERFEAQSEEYKnTVIppelkkrmTIEAGTTYGW-----AKYAGDHGVMI---GID-EFGMSAPSDIVL 664
Cdd:PRK12315 492 LInpkfiTGLDEELLEKLKEDHE-LVV--------TLEDGILDGGfgekiARYYGNSDMKVlnyGAKkEFNDRVPVEELY 562

                        570
                 ....*....|..
gi 695721597 665 RELGMSVENIVD 676
Cdd:PRK12315 563 KRNHLTPEQIVE 574

TPP_E1_EcPDC_like

cd02017

Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...

38-236

5.29e-08

Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.

Pssm-ID: 238975 [Multi-domain] Cd Length: 386 Bit Score: 55.39 E-value: 5.29e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  38 AIQRANS------GHPGLPMGAAPMAYVLWTrHLKinpKTHMNWVNRDRfVLSAGHGSALLYSLAHLAGyDVSMDDLKNF 111
Cdd:cd02017   18 MVHRANKkdlgigGHIATFASAATLYEVGFN-HFF---RARGEGGGGDL-VYFQGHASPGIYARAFLEG-RLTEEQLDNF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 112 REWKSNtPGHPEY----GCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKfnreGYPVM-DHYTYALIGDGDLMEGVASE 186
Cdd:cd02017   92 RQEVGG-GGLSSYphpwLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDR----GLKDTsDQKVWAFLGDGEMDEPESLG 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695721597 187 AASLAGHLKLGKLIALYDSNGISLDGKTSASFT--ENVGARFEAYGWQYILV 236
Cdd:cd02017  167 AIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKiiQELEGIFRGAGWNVIKV 218

TPP_E1_PDC_ADC_BCADC

cd02000

Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...

132-266

1.44e-07

Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).

Pssm-ID: 238958 [Multi-domain] Cd Length: 293 Bit Score: 53.65 E-value: 1.44e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 132 ATTGPLGQGISMAVGMAMAEAHLGKkfnregypvmDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDsNGISLD 211
Cdd:cd02000  101 GGNGIVGGQVPLAAGAALALKYRGE----------DRVAVCFFGDGATNEGDFHEALNFAALWKLPVIFVCEN-NGYAIS 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695721597 212 GKTS-ASFTENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKA---ESDKPTIIEIKT 266
Cdd:cd02000  170 TPTSrQTAGTSIADRAAAYGIPGIRV-DGNDVLAVYEAAKEAVErarAGGGPTLIEAVT 227

TPP_BFDC

cd02002

Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ...

87-266

2.63e-05

Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.

Pssm-ID: 238960 [Multi-domain] Cd Length: 178 Bit Score: 45.28 E-value: 2.63e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  87 HGSALLYSLAHLAGYDVSMDD--LKNFREWKSNTPG---HPEYGCTdgveatTGPLGQGISMAVGMAMAEAhlgkkfnre 161
Cdd:cd02002    2 TPEYLAAALAAALPEDAIIVDeaVTNGLPLRDQLPLtrpGSYFTLR------GGGLGWGLPAAVGAALANP--------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 162 gypvmDHYTYALIGDGDLMEGVasEAASLAGHLKLGKLIALYDSNGISldgkTSASFTENVGA----------------- 224
Cdd:cd02002   67 -----DRKVVAIIGDGSFMYTI--QALWTAARYGLPVTVVILNNRGYG----ALRSFLKRVGPegpgenapdgldlldpg 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 695721597 225 -RF----EAYGWQYILVEDGfnlEEIDKAIVQAKAEsDKPTIIEIKT 266
Cdd:cd02002  136 iDFaaiaKAFGVEAERVETP---EELDEALREALAE-GGPALIEVVV 178

E1_dh

pfam00676

Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...

135-346

6.56e-04

Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.

Pssm-ID: 395548 [Multi-domain] Cd Length: 300 Bit Score: 42.31 E-value: 6.56e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  135 GPLGQGISMAVGMAMAEAHLGKKfnregypvmdHYTYALIGDGDLMEGVASEAASLAGHLKLgKLIALYDSN--GISLDG 212
Cdd:pfam00676 101 GILGAQVPLGAGIALAAKYRGKK----------EVAITLYGDGAANQGDFFEGLNFAALWKL-PVIFVCENNqyGISTPA 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597  213 KTSASfTENVGARFEAYGWQYILVeDGFNLEEIDKAIVQAKA---ESDKPTIIEIKTtigygsenqgtHKVHGSPLGEEG 289
Cdd:pfam00676 170 ERASA-STTYADRARGYGIPGLHV-DGMDPLAVYQASKFAAErarTGKGPFLIELVT-----------YRYGGHSMSDDP 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 695721597  290 VAH--AKEVYNWNYPPftvpeEVSQRFKECLQDKGVKAENKWNEMFEAYKKEYSDLAQK 346
Cdd:pfam00676 237 STYrtRDEYEEVRKKK-----DPIQRFKEHLVSKGVWSEEELKAIEKEVRKEVEEAFKK 290

AcoA

COG1071

TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and ...

133-267

8.36e-04

TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha is part of the Pathway/BioSystem: Pyruvate oxidation

Pssm-ID: 440689 [Multi-domain] Cd Length: 348 Bit Score: 42.05 E-value: 8.36e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 133 TTGPLGQGISMAVGMAMAEAHLGKkfnregypvmDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDsNG--ISl 210
Cdd:COG1071  125 GSGIVGGQLPHAVGAALAAKLRGE----------DEVAVAFFGDGATSEGDFHEALNFAAVWKLPVVFVCEN-NGyaIS- 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695721597 211 dgkTS---ASFTENVGARFEAYGWQYILVeDGFNLEE----IDKAIVQAKAEsDKPTIIEIKTT 267
Cdd:COG1071  193 ---TPverQTAVETIADRAAGYGIPGVRV-DGNDVLAvyaaVKEAVERARAG-EGPTLIEAKTY 251

PLN02234

1-deoxy-D-xylulose-5-phosphate synthase

134-271

2.53e-03

1-deoxy-D-xylulose-5-phosphate synthase

Pssm-ID: 177878 [Multi-domain] Cd Length: 641 Bit Score: 40.85 E-value: 2.53e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 134 TGPLGQGISMAVGMAMAEAHLGkkfnregypvMDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDSNGISLDGK 213
Cdd:PLN02234 176 TGHSSTTLSAGLGMAVGRDLKG----------MNNSVVSVIGDGAMTAGQAYEAMNNAGYLHSNMIVILNDNKQVSLPTA 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 214 TSASFTENVGA---------------------RFEAYGWQYILVEDGFNLEEIDKAIVQAKA-ESDKPTIIEIKTTIGYG 271
Cdd:PLN02234 246 NLDGPTQPVGAlscalsrlqsncgmiretsstLFEELGFHYVGPVDGHNIDDLVSILETLKStKTIGPVLIHVVTEKGRG 325

PLN02582

1-deoxy-D-xylulose-5-phosphate synthase

468-599

6.55e-03

1-deoxy-D-xylulose-5-phosphate synthase

Pssm-ID: 178194 [Multi-domain] Cd Length: 677 Bit Score: 39.88 E-value: 6.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 468 IQKLPVIYVLTHDSVaVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQN--LDTLP 545
Cdd:PLN02582 446 LQKLPVRFAMDRAGL-VGADGPTHCGAFDVTYMACLPNMVVMAPSDEAELFHMVATAAAIDDRPSCFRYPRGNgiGVQLP 524

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695721597 546 ISKEKVFDGVEKGGYVVQGAENEadgiLIATGSEVGLALKAKEELQKKGKDVIV 599
Cdd:PLN02582 525 PNNKGIPIEVGKGRILLEGERVA----LLGYGTAVQSCLAAASLLERHGLSATV 574

PLN02582

1-deoxy-D-xylulose-5-phosphate synthase

125-224

9.22e-03

1-deoxy-D-xylulose-5-phosphate synthase

Pssm-ID: 178194 [Multi-domain] Cd Length: 677 Bit Score: 39.11 E-value: 9.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695721597 125 GCTDGVEATTGPLGQG-----ISMAVGMAMAEAHLGKKFNregypvmdhyTYALIGDGDLMEGVASEAASLAGHLKLGKL 199
Cdd:PLN02582 129 GFTKRAESEYDCFGTGhssttISAGLGMAVGRDLKGKKNN----------VVAVIGDGAMTAGQAYEAMNNAGYLDSDMI 198

                         90       100
                 ....*....|....*....|....*
gi 695721597 200 IALYDSNGISLDGKTSASFTENVGA 224
Cdd:PLN02582 199 VILNDNKQVSLPTATLDGPAPPVGA 223

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01