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Conserved domains on  [gi|695599480|ref|WP_032604223|]
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arsenite efflux transporter membrane subunit ArsB [Staphylococcus epidermidis]

Protein Classification

arsenic transporter( domain architecture ID 10794163)

arsenic transporter, an arsenical pump membrane protein, is involved in arsenical resistance and thought to form the channel of an arsenite pump

Gene Ontology:  GO:0005886|GO:0015105|GO:0046685
PubMed:  1688427
TCDB:  2.A.45

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
3-429 0e+00

arsenical efflux pump membrane protein ArsB;


:

Pssm-ID: 185342  Cd Length: 427  Bit Score: 706.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:PRK15445   1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:PRK15445  81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:PRK15445 161 IVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:PRK15445 241 EPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAAT 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:PRK15445 321 LGTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400

                        410       420
                 ....*....|....*....|....*..
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLIIF 429
Cdd:PRK15445 401 YFKVGIIITLPVLLVTLLALALRLSLF 427
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
3-429 0e+00

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 706.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:PRK15445   1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:PRK15445  81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:PRK15445 161 IVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:PRK15445 241 EPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAAT 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:PRK15445 321 LGTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400

                        410       420
                 ....*....|....*....|....*..
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLIIF 429
Cdd:PRK15445 401 YFKVGIIITLPVLLVTLLALALRLSLF 427
2a45 TIGR00935
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ...
 3-428 0e+00

arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]


Pssm-ID: 213571  Cd Length: 426  Bit Score: 637.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:TIGR00935   1 ILAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:TIGR00935  81 HMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:TIGR00935 161 IVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:TIGR00935 241 EFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVAT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:TIGR00935 321 MGMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400

                         410       420
                  ....*....|....*....|....*.
gi 695599480  403 YFKIGIIITIPVLFITLLGLYLTLII 428
Cdd:TIGR00935 401 YFKVGIVITVPVLFITLAGLYLRLSI 426
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 4-423 1.63e-165

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 471.36  E-value: 1.63e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:cd01118    1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:cd01118   81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01118  161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01118  241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQsqttSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:cd01118  321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396

                        410       420
                 ....*....|....*....|
gi 695599480 404 FKIGIIITIPVLFITLLGLY 423
Cdd:cd01118  397 LKVGLIVTPPVLVVTLAALI 416
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
1-427 1.60e-115

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 344.03  E-value: 1.60e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   1 MTILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:COG1055    1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNL 160
Cdd:COG1055   79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN---PVPFLIAIVFAANIGGAATPIGNP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 161 VNIVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDavNIREPKEAIKDKKLFNISWIVLTVLLVGYL 240
Cdd:COG1055  156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 241 ISEFINIPVSIIAGIIALIFVLLARkskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFS 320
Cdd:COG1055  234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 321 SIMGMGFISAFLSSIMNNMPTVLIDAIAIgQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISW 400
Cdd:COG1055  310 AALLILWLSAILSAVVDNVPLVAALLPLI-PDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388

                        410       420
                 ....*....|....*....|....*..
gi 695599480 401 GTYFKIGIIITIPVLFITLLGLYLTLI 427
Cdd:COG1055  389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
ArsB pfam02040
Arsenical pump membrane protein;
4-426 9.82e-106

Arsenical pump membrane protein;


Pssm-ID: 460426  Cd Length: 423  Bit Score: 319.62  E-value: 9.82e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:pfam02040   1 LASFIFALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:pfam02040  81 MAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:pfam02040 161 NLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:pfam02040 241 FFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQAAAAGGI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  324 GMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400

                         410       420
                  ....*....|....*....|...
gi 695599480  404 FKIGIIITIPVLFITLLGLYLTL 426
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
3-429 0e+00

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 706.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:PRK15445   1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:PRK15445  81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:PRK15445 161 IVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:PRK15445 241 EPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAAT 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:PRK15445 321 LGTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400

                        410       420
                 ....*....|....*....|....*..
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLIIF 429
Cdd:PRK15445 401 YFKVGIIITLPVLLVTLLALALRLSLF 427
2a45 TIGR00935
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ...
 3-428 0e+00

arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]


Pssm-ID: 213571  Cd Length: 426  Bit Score: 637.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:TIGR00935   1 ILAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:TIGR00935  81 HMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:TIGR00935 161 IVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:TIGR00935 241 EFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVAT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:TIGR00935 321 MGMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400

                         410       420
                  ....*....|....*....|....*.
gi 695599480  403 YFKIGIIITIPVLFITLLGLYLTLII 428
Cdd:TIGR00935 401 YFKVGIVITVPVLFITLAGLYLRLSI 426
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 4-423 1.63e-165

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 471.36  E-value: 1.63e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:cd01118    1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:cd01118   81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01118  161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01118  241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQsqttSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:cd01118  321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396

                        410       420
                 ....*....|....*....|
gi 695599480 404 FKIGIIITIPVLFITLLGLY 423
Cdd:cd01118  397 LKVGLIVTPPVLVVTLAALI 416
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
1-427 1.60e-115

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 344.03  E-value: 1.60e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   1 MTILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:COG1055    1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNL 160
Cdd:COG1055   79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN---PVPFLIAIVFAANIGGAATPIGNP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 161 VNIVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDavNIREPKEAIKDKKLFNISWIVLTVLLVGYL 240
Cdd:COG1055  156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 241 ISEFINIPVSIIAGIIALIFVLLARkskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFS 320
Cdd:COG1055  234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 321 SIMGMGFISAFLSSIMNNMPTVLIDAIAIgQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISW 400
Cdd:COG1055  310 AALLILWLSAILSAVVDNVPLVAALLPLI-PDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388

                        410       420
                 ....*....|....*....|....*..
gi 695599480 401 GTYFKIGIIITIPVLFITLLGLYLTLI 427
Cdd:COG1055  389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
ArsB pfam02040
Arsenical pump membrane protein;
4-426 9.82e-106

Arsenical pump membrane protein;


Pssm-ID: 460426  Cd Length: 423  Bit Score: 319.62  E-value: 9.82e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:pfam02040   1 LASFIFALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:pfam02040  81 MAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:pfam02040 161 NLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:pfam02040 241 FFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQAAAAGGI 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  324 GMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400

                         410       420
                  ....*....|....*....|...
gi 695599480  404 FKIGIIITIPVLFITLLGLYLTL 426
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 15-422 4.38e-70

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 226.75  E-value: 4.38e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  15 FVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASKGNGLK 94
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--AIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  95 MFvYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFGFV 174
Cdd:cd00625   79 LL-LLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP--PVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 175 EYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDA--VNIREPKEAIKDKKLFNISWIVLTVLLVGYLiseFINIPVSII 252
Cdd:cd00625  156 DFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDklTVLAEPLPARPLLKKFLLLALLLLLLFVLLF---FFLIPLGLI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 253 AGIIALIFVLLARKSkaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFL 332
Cdd:cd00625  233 ALLGALLLLLLLVRG--LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 333 SSIMNNMPTVLIDAIAIGQSQTTSILkegmIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTYFKIGIIITI 412
Cdd:cd00625  311 SNFISNVPTVALLLPIAASLAPPEPA----WLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTL 386

                        410
                 ....*....|
gi 695599480 413 PVLFITLLGL 422
Cdd:cd00625  387 LSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
13-365 3.02e-39

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 143.99  E-value: 3.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   13 LIFVIWQPkgLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASKGNG 92
Cdd:pfam03600   1 YVLIITEK--LPRDVVALLGAVLLVLLGVLTPEEALS--GIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   93 LKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFG 172
Cdd:pfam03600  77 RRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP---PSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  173 FVEYFSKMIIPNIFSLIAS-ILVLWLYFRKSIPRKFD--AVNIREPKEAIKDKKLFNISWIVLTVLLVGYlisefinipv 249
Cdd:pfam03600 154 FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEeeAELEELRKRAIKDKLLLAISALVLALVILGF---------- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  250 sIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISsyGLFSSIMGMGFIS 329
Cdd:pfam03600 224 -LLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLS 300

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 695599480  330 AFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYA 365
Cdd:pfam03600 301 ALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 9-424 2.84e-38

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 143.16  E-value: 2.84e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   9 FILTLIFVIWQPkgLDIGITALIGAVVAIITGVVSFSDVLE--VTGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVR 86
Cdd:cd01116    1 FIITYALIIFEK--VHRTVAALAGALWLVILGLATLSPDLEtiVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  87 ASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSA 166
Cdd:cd01116   79 ISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLN---PVPVLISEVIAANIGGAATLIGDPPNIMIG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 167 DYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIR---EPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01116  156 SAAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALaelEPKYPIKDKVLLLKSLTILTLVIIGFVLHS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01116  236 PLGVSLGWIALLGALLLLLLADK---LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVI 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:cd01116  313 LILWISALLSAFIDNIPVTATMIpIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWE 392

                        410       420
                 ....*....|....*....|..
gi 695599480 403 YFKIGIIITIpvLFITLLGLYL 424
Cdd:cd01116  393 FLKVGFPIML--VSLILATVYL 412
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 29-420 9.16e-24

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 101.97  E-value: 9.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  29 ALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRaSKGNGLKMFVYIMFLGAIVAA 108
Cdd:cd01117   17 ALLGAALMLLFGVISLEDAPAA--IDLDTIILLFGLMVVSAALELSGFFDALGSRILV-KAGSPRRLLFLLVLLSGILSA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 109 FFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFGFVEYFSKMIIPNIFSL 188
Cdd:cd01117   94 LLTNDTACLVFTPIVLELARVAGLP---PIPLLLALATAANIGSAATPIGNPQNLLIASESGISFPFFLAAMAPLALLGL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 189 IASILVLWLYFRKSIPRKFDAVNIREPKEaIKDKKLFNISWIVLTVLLVGYLISEFINIPVSIIAGIIALIFVllarksk 268
Cdd:cd01117  171 LLLLILLLVLFPGELKGLPLDKATKEEGV-GARKLAVKLLVLILLLLVAFLALLGVIPLWTAALVAAVLLLLT------- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 269 AVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSsimgmgFISAFLSSIMNNMPTVLIDAIA 348
Cdd:cd01117  243 RLKPRRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLLDSVLSLF------LVSIGLSQLISNVPAVLLLLPF 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695599480 349 IGQSQTTSILkegmiyANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTYFKIGIIITIPVLFITLL 420
Cdd:cd01117  317 LPSADEKDWL------LLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGIL 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
62-424 2.45e-16

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 79.81  E-value: 2.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  62 VAVILISLILDEIGFFEWSAIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFP-- 139
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGsa 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 140 FIIASGFIADTTSLPLIVSNLVNIVSADYF------DFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNI- 212
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLeeatgiPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVi 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 213 ---REPKEAIKDKKLFNISWIVLTVLLVgyLISEFINIPVSIIAGIIALIFVLLarksKAVHTKQVIKGAPWNIVLFSIG 289
Cdd:COG0471  161 reeLAELGPLSRREKIALAIFALTVLLW--ITGSLHGIPIAVVALLGAVLLLLT----GVLTWKDAYKSIPWGVLLLFGG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 290 MYLVVFGLKNVGITTLLGDVLTN-ISSYGLFSSIMGMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANV 367
Cdd:COG0471  235 GLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLpIAISLAQALGVNPLPLALAVA 314

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695599480 368 IGSDLGPkITPIGSLATLLwlhVLTQKGVKIswGTYFKIGIIITIPVLFITLLGLYL 424
Cdd:COG0471  315 FAASCAF-LLPVGTPPNAI---VYGSGYYKF--KDFLKVGLPLNLIGLVVLLLLGPL 365
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 10-424 2.90e-15

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 76.85  E-value: 2.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  10 ILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLevTGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASK 89
Cdd:cd01115    3 ILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAF--SGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  90 GNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLpliVSNLVNIVSADYF 169
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTL---IGTPPNLVASGYL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 170 D------FGFVEYFSKMIIpnifSLIASILVLWLYFRKSIprkfdavnirepkeaikdkklfniswIVLTVLLVGYLISE 243
Cdd:cd01115  158 EslggqgFSFFEFTPIGLP----LLIIGLLYLWFIFRLAV--------------------------LIITIVLLAALAAI 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLlarkSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNI-SSYGLFSSI 322
Cdd:cd01115  208 TGLLPVSVAIAIGAIVLVF----GGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLlGGLPPFAIL 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANVIGSDLgPKITPIGSLATLLwlhVLTQKGVKISwg 401
Cdd:cd01115  284 LLLCLLTLVLTNFISNTATAVLLApIALSIALSLGLPPEALLLAVAIGASC-AFMLPVGTPPNAI---VLGPGGYKFS-- 357

                        410       420
                 ....*....|....*....|...
gi 695599480 402 TYFKIGIIITIPVLFITLLGLYL 424
Cdd:cd01115  358 DFAKVGLPLSILSLVVSVTMIPL 380
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
3-200 1.19e-09

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 59.40  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   3 ILAITIFILTLIFVIWQP-KGLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSA 81
Cdd:COG0471  175 KIALAIFALTVLLWITGSlHGIPIAVVALLGAVLLLLTGVLTWKDAYK--SIPWGVLLLFGGGLALGAALEKTGLAAWLA 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  82 IHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGA-ALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLpLIVSNL 160
Cdd:COG0471  253 DALLPLLGGLSPLLLLLLLALLTLLLTEFASNTAtAALLLPIAISLAQALGVN---PLPLALAVAFAASCAFL-LPVGTP 328

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 695599480 161 VNIV--SADYFDFGfvEYFSKMIIPNIFSLIASILVLWLYFR 200
Cdd:COG0471  329 PNAIvyGSGYYKFK--DFLKVGLPLNLIGLVVLLLLGPLWWP 368
PLN00136 PLN00136
silicon transporter; Provisional
 1-344 3.86e-05

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 45.76  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   1 MTILAITIFILTLIF--VIWQPKGLDIGitALIGAVVAIITGVVSFSDV-----LEVTGIVWnatltfvAVILISLILDE 73
Cdd:PLN00136  11 LGSLAFGVFWMLAVFpsVPFLPIGRTAG--ALLSAVLMIVFHVISPDDAyasidLPILGLLF-------ATMVVGSYLKN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  74 IGFFEWSAIHMVRASKGnGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKavfPFIIASGFIADTTSL 153
Cdd:PLN00136  82 AGMFKHLGRLLAWRSQG-GRDLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAK---PFLLALASSANIGSS 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 154 PLIVSNLVNIVSADYFDFGFVEYFSKmIIPNIFSLIA--SILVLWLYFR---------------------------KSIP 204
Cdd:PLN00136 158 ATPIGNPQNLVIAFNSKITFPKFLLG-ILPAMLAGMAvnMVMLLCMYWKdldggaelsvdgkqmeaveegrspasaKSTK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 205 RKFDAVNIREPK------------EAIKDK------------KLF--NISWIVLTVLLVGYLISefINIPVSIIAGIIAL 258
Cdd:PLN00136 237 QQSPALLQAGLNgdgngdmssmmsENISTKhpwfmqctehrrKLFlkSFAYVVTVGMVVAYMVG--LNMSWTAITTAIAL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 259 IFVLLARKSKAVHTkqvikgAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFLSSIMNN 338
Cdd:PLN00136 315 VVVDFRDAEPCLDT------VSYSLLVFFSGMFITVSGFNKTGLPGAIWNFMAPYSKVNSVGGISVLSVIILLLSNLASN 388


                 ....*.
gi 695599480 339 MPTVLI 344
Cdd:PLN00136 389 VPTVLL 394
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 3-131 5.99e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 44.94  E-value: 5.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   3 ILAITIFILTLI-FVIWQPKGLDIGITALIGAVVA-IITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:cd01116  218 LKSLTILTLVIIgFVLHSPLGVSLGWIALLGALLLlLLADKLDFEDVLS--RVEWDTLLFFAGLFVLVGGLEELGIIEWI 295

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695599480  81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLG 131
Cdd:cd01116  296 AELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLG 346
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 4-380 2.44e-03

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 40.02  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    4 LAITIFILTLIFVIWQPKGLdiGITALIGA-VVAIITGVVSFSDVLEV-----TGIVWnatLTFVAVILiSLILDEIGFF 77
Cdd:TIGR00785  12 LLLAIFVAAIVGWILEPLPL--PVTALLAIpIIAVLLGVLSAFKFKNAlsgfaDPTIW---LFFGAFIL-ATALVKTGLG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480   78 EWSAIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGA--ALILTPIVLAMVRSLG----FDKKAVFPFIIASGFIAD-T 150
Cdd:TIGR00785  86 KRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTAraGGILLPIIKSLLPLLGskpeKSPRKIGKYLMLGIAYSAsI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  151 TSLPLIVSNLVNIVSADY------FDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVniREPKEAIKDKKL 224
Cdd:TIGR00785 166 GSSGFLTGSAPNALAAGIlskilgIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVD--LWAKEELEEMGP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  225 FNISWIVLTVLLVGYLISEFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKG-APWNIVLFSIGMYLVVFGLKNVGIT 303
Cdd:TIGR00785 244 MSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNkVAWNTLILFGGLIGLAGGLKKSGFI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480  304 TLLGDVLTNISSyGLFSSIMGMGFISAFLSSIMNNMP----TVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPI 379
Cdd:TIGR00785 324 KWFSEKLVGILD-GLSPTIAVLVLVVLFYIILYFFASntahTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPY 402


                  .
gi 695599480  380 G 380
Cdd:TIGR00785 403 A 403
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
288-426 7.62e-03

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 38.21  E-value: 7.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 288 IGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFLSSIMNNMPTVLI------DAIAIGQSQTTSILKEG 361
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMmlpialSIAAALGSEKRSKFGSA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695599480 362 MIYANVIGSDLGPKITPIGSLATLLWLHVL-TQKGVKISWGTYFKIGIIITIPVLFITLLGLYLTL 426
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLeEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLL 146
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 3-130 8.68e-03

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 38.12  E-value: 8.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480    3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGiVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:pfam00939 271 ALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWKDIVKNKG-AWNTLIWLGGLIMLANGLERSGFIEWLGN 349

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 695599480   83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALI--LTPIVLAMVRSL 130
Cdd:pfam00939 350 TLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTaaMLPIFAAVAQAI 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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