|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
3-429 |
0e+00 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 706.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:PRK15445 1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:PRK15445 81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:PRK15445 161 IVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:PRK15445 241 EPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAAT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:PRK15445 321 LGTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400
|
410 420
....*....|....*....|....*..
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLIIF 429
Cdd:PRK15445 401 YFKVGIIITLPVLLVTLLALALRLSLF 427
|
|
| 2a45 |
TIGR00935 |
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ... |
3-428 |
0e+00 |
|
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]
Pssm-ID: 213571 Cd Length: 426 Bit Score: 637.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:TIGR00935 1 ILAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:TIGR00935 81 HMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:TIGR00935 161 IVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:TIGR00935 241 EFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVAT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:TIGR00935 321 MGMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400
|
410 420
....*....|....*....|....*.
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLII 428
Cdd:TIGR00935 401 YFKVGIVITVPVLFITLAGLYLRLSI 426
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
4-423 |
1.63e-165 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 471.36 E-value: 1.63e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:cd01118 1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:cd01118 81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01118 161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01118 241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQsqttSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:cd01118 321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396
|
410 420
....*....|....*....|
gi 695599480 404 FKIGIIITIPVLFITLLGLY 423
Cdd:cd01118 397 LKVGLIVTPPVLVVTLAALI 416
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
1-427 |
1.60e-115 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 344.03 E-value: 1.60e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 1 MTILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNL 160
Cdd:COG1055 79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN---PVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 161 VNIVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDavNIREPKEAIKDKKLFNISWIVLTVLLVGYL 240
Cdd:COG1055 156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 241 ISEFINIPVSIIAGIIALIFVLLARkskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFS 320
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 321 SIMGMGFISAFLSSIMNNMPTVLIDAIAIgQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISW 400
Cdd:COG1055 310 AALLILWLSAILSAVVDNVPLVAALLPLI-PDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388
|
410 420
....*....|....*....|....*..
gi 695599480 401 GTYFKIGIIITIPVLFITLLGLYLTLI 427
Cdd:COG1055 389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB |
pfam02040 |
Arsenical pump membrane protein; |
4-426 |
9.82e-106 |
|
Arsenical pump membrane protein;
Pssm-ID: 460426 Cd Length: 423 Bit Score: 319.62 E-value: 9.82e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:pfam02040 1 LASFIFALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:pfam02040 81 MAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:pfam02040 161 NLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:pfam02040 241 FFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQAAAAGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400
|
410 420
....*....|....*....|...
gi 695599480 404 FKIGIIITIPVLFITLLGLYLTL 426
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
3-429 |
0e+00 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 706.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:PRK15445 1 LLAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:PRK15445 81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:PRK15445 161 IVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:PRK15445 241 EPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAAT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:PRK15445 321 LGTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400
|
410 420
....*....|....*....|....*..
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLIIF 429
Cdd:PRK15445 401 YFKVGIIITLPVLLVTLLALALRLSLF 427
|
|
| 2a45 |
TIGR00935 |
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ... |
3-428 |
0e+00 |
|
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]
Pssm-ID: 213571 Cd Length: 426 Bit Score: 637.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:TIGR00935 1 ILAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVN 162
Cdd:TIGR00935 81 HMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 163 IVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLIS 242
Cdd:TIGR00935 161 IVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 243 EFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSI 322
Cdd:TIGR00935 241 EFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVAT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:TIGR00935 321 MGMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGY 400
|
410 420
....*....|....*....|....*.
gi 695599480 403 YFKIGIIITIPVLFITLLGLYLTLII 428
Cdd:TIGR00935 401 YFKVGIVITVPVLFITLAGLYLRLSI 426
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
4-423 |
1.63e-165 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 471.36 E-value: 1.63e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:cd01118 1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:cd01118 81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01118 161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01118 241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQsqttSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:cd01118 321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396
|
410 420
....*....|....*....|
gi 695599480 404 FKIGIIITIPVLFITLLGLY 423
Cdd:cd01118 397 LKVGLIVTPPVLVVTLAALI 416
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
1-427 |
1.60e-115 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 344.03 E-value: 1.60e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 1 MTILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNL 160
Cdd:COG1055 79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLN---PVPFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 161 VNIVSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDavNIREPKEAIKDKKLFNISWIVLTVLLVGYL 240
Cdd:COG1055 156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 241 ISEFINIPVSIIAGIIALIFVLLARkskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFS 320
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 321 SIMGMGFISAFLSSIMNNMPTVLIDAIAIgQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISW 400
Cdd:COG1055 310 AALLILWLSAILSAVVDNVPLVAALLPLI-PDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388
|
410 420
....*....|....*....|....*..
gi 695599480 401 GTYFKIGIIITIPVLFITLLGLYLTLI 427
Cdd:COG1055 389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB |
pfam02040 |
Arsenical pump membrane protein; |
4-426 |
9.82e-106 |
|
Arsenical pump membrane protein;
Pssm-ID: 460426 Cd Length: 423 Bit Score: 319.62 E-value: 9.82e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 4 LAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGIVWNATLTFVAVILISLILDEIGFFEWSAIH 83
Cdd:pfam02040 1 LASFIFALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 84 MVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLPLIVSNLVNI 163
Cdd:pfam02040 81 MAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 164 VSADYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIREPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:pfam02040 161 NLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:pfam02040 241 FFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQAAAAGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTY 403
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400
|
410 420
....*....|....*....|...
gi 695599480 404 FKIGIIITIPVLFITLLGLYLTL 426
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
15-422 |
4.38e-70 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 226.75 E-value: 4.38e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 15 FVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASKGNGLK 94
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--AIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 95 MFvYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFGFV 174
Cdd:cd00625 79 LL-LLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP--PVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 175 EYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDA--VNIREPKEAIKDKKLFNISWIVLTVLLVGYLiseFINIPVSII 252
Cdd:cd00625 156 DFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDklTVLAEPLPARPLLKKFLLLALLLLLLFVLLF---FFLIPLGLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 253 AGIIALIFVLLARKSkaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFL 332
Cdd:cd00625 233 ALLGALLLLLLLVRG--LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 333 SSIMNNMPTVLIDAIAIGQSQTTSILkegmIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTYFKIGIIITI 412
Cdd:cd00625 311 SNFISNVPTVALLLPIAASLAPPEPA----WLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTL 386
|
410
....*....|
gi 695599480 413 PVLFITLLGL 422
Cdd:cd00625 387 LSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
13-365 |
3.02e-39 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 143.99 E-value: 3.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 13 LIFVIWQPkgLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASKGNG 92
Cdd:pfam03600 1 YVLIITEK--LPRDVVALLGAVLLVLLGVLTPEEALS--GIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 93 LKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFG 172
Cdd:pfam03600 77 RRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP---PSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 173 FVEYFSKMIIPNIFSLIAS-ILVLWLYFRKSIPRKFD--AVNIREPKEAIKDKKLFNISWIVLTVLLVGYlisefinipv 249
Cdd:pfam03600 154 FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEeeAELEELRKRAIKDKLLLAISALVLALVILGF---------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 250 sIIAGIIALIFVLLARKSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISsyGLFSSIMGMGFIS 329
Cdd:pfam03600 224 -LLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLS 300
|
330 340 350
....*....|....*....|....*....|....*.
gi 695599480 330 AFLSSIMNNMPTVLIDAIAIGQSQTTSILKEGMIYA 365
Cdd:pfam03600 301 ALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
9-424 |
2.84e-38 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 143.16 E-value: 2.84e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 9 FILTLIFVIWQPkgLDIGITALIGAVVAIITGVVSFSDVLE--VTGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVR 86
Cdd:cd01116 1 FIITYALIIFEK--VHRTVAALAGALWLVILGLATLSPDLEtiVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 87 ASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSA 166
Cdd:cd01116 79 ISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLN---PVPVLISEVIAANIGGAATLIGDPPNIMIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 167 DYFDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNIR---EPKEAIKDKKLFNISWIVLTVLLVGYLISE 243
Cdd:cd01116 156 SAAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALaelEPKYPIKDKVLLLKSLTILTLVIIGFVLHS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLLARKskaVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIM 323
Cdd:cd01116 236 PLGVSLGWIALLGALLLLLLADK---LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 324 GMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGT 402
Cdd:cd01116 313 LILWISALLSAFIDNIPVTATMIpIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWE 392
|
410 420
....*....|....*....|..
gi 695599480 403 YFKIGIIITIpvLFITLLGLYL 424
Cdd:cd01116 393 FLKVGFPIML--VSLILATVYL 412
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
29-420 |
9.16e-24 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 101.97 E-value: 9.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 29 ALIGAVVAIITGVVSFSDVLEVtgIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRaSKGNGLKMFVYIMFLGAIVAA 108
Cdd:cd01117 17 ALLGAALMLLFGVISLEDAPAA--IDLDTIILLFGLMVVSAALELSGFFDALGSRILV-KAGSPRRLLFLLVLLSGILSA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 109 FFANDGAALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLPLIVSNLVNIVSADYFDFGFVEYFSKMIIPNIFSL 188
Cdd:cd01117 94 LLTNDTACLVFTPIVLELARVAGLP---PIPLLLALATAANIGSAATPIGNPQNLLIASESGISFPFFLAAMAPLALLGL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 189 IASILVLWLYFRKSIPRKFDAVNIREPKEaIKDKKLFNISWIVLTVLLVGYLISEFINIPVSIIAGIIALIFVllarksk 268
Cdd:cd01117 171 LLLLILLLVLFPGELKGLPLDKATKEEGV-GARKLAVKLLVLILLLLVAFLALLGVIPLWTAALVAAVLLLLT------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 269 AVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSsimgmgFISAFLSSIMNNMPTVLIDAIA 348
Cdd:cd01117 243 RLKPRRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLLDSVLSLF------LVSIGLSQLISNVPAVLLLLPF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695599480 349 IGQSQTTSILkegmiyANVIGSDLGPKITPIGSLATLLWLHVLTQKGVKISWGTYFKIGIIITIPVLFITLL 420
Cdd:cd01117 317 LPSADEKDWL------LLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGIL 382
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
62-424 |
2.45e-16 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 79.81 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 62 VAVILISLILDEIGFFEWSAIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFP-- 139
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGsa 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 140 FIIASGFIADTTSLPLIVSNLVNIVSADYF------DFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVNI- 212
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLeeatgiPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 213 ---REPKEAIKDKKLFNISWIVLTVLLVgyLISEFINIPVSIIAGIIALIFVLLarksKAVHTKQVIKGAPWNIVLFSIG 289
Cdd:COG0471 161 reeLAELGPLSRREKIALAIFALTVLLW--ITGSLHGIPIAVVALLGAVLLLLT----GVLTWKDAYKSIPWGVLLLFGG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 290 MYLVVFGLKNVGITTLLGDVLTN-ISSYGLFSSIMGMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANV 367
Cdd:COG0471 235 GLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLpIAISLAQALGVNPLPLALAVA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 695599480 368 IGSDLGPkITPIGSLATLLwlhVLTQKGVKIswGTYFKIGIIITIPVLFITLLGLYL 424
Cdd:COG0471 315 FAASCAF-LLPVGTPPNAI---VYGSGYYKF--KDFLKVGLPLNLIGLVVLLLLGPL 365
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
10-424 |
2.90e-15 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 76.85 E-value: 2.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 10 ILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLevTGIVWNATLTFVAVILISLILDEIGFFEWSAIHMVRASK 89
Cdd:cd01115 3 ILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAF--SGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 90 GNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKAVFPFIIASGFIADTTSLpliVSNLVNIVSADYF 169
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTL---IGTPPNLVASGYL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 170 D------FGFVEYFSKMIIpnifSLIASILVLWLYFRKSIprkfdavnirepkeaikdkklfniswIVLTVLLVGYLISE 243
Cdd:cd01115 158 EslggqgFSFFEFTPIGLP----LLIIGLLYLWFIFRLAV--------------------------LIITIVLLAALAAI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 244 FINIPVSIIAGIIALIFVLlarkSKAVHTKQVIKGAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNI-SSYGLFSSI 322
Cdd:cd01115 208 TGLLPVSVAIAIGAIVLVF----GGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLlGGLPPFAIL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 323 MGMGFISAFLSSIMNNMPTVLIDA-IAIGQSQTTSILKEGMIYANVIGSDLgPKITPIGSLATLLwlhVLTQKGVKISwg 401
Cdd:cd01115 284 LLLCLLTLVLTNFISNTATAVLLApIALSIALSLGLPPEALLLAVAIGASC-AFMLPVGTPPNAI---VLGPGGYKFS-- 357
|
410 420
....*....|....*....|...
gi 695599480 402 TYFKIGIIITIPVLFITLLGLYL 424
Cdd:cd01115 358 DFAKVGLPLSILSLVVSVTMIPL 380
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
3-200 |
1.19e-09 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 59.40 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQP-KGLDIGITALIGAVVAIITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWSA 81
Cdd:COG0471 175 KIALAIFALTVLLWITGSlHGIPIAVVALLGAVLLLLTGVLTWKDAYK--SIPWGVLLLFGGGLALGAALEKTGLAAWLA 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 82 IHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGA-ALILTPIVLAMVRSLGFDkkaVFPFIIASGFIADTTSLpLIVSNL 160
Cdd:COG0471 253 DALLPLLGGLSPLLLLLLLALLTLLLTEFASNTAtAALLLPIAISLAQALGVN---PLPLALAVAFAASCAFL-LPVGTP 328
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 695599480 161 VNIV--SADYFDFGfvEYFSKMIIPNIFSLIASILVLWLYFR 200
Cdd:COG0471 329 PNAIvyGSGYYKFK--DFLKVGLPLNLIGLVVLLLLGPLWWP 368
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
1-344 |
3.86e-05 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 45.76 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 1 MTILAITIFILTLIF--VIWQPKGLDIGitALIGAVVAIITGVVSFSDV-----LEVTGIVWnatltfvAVILISLILDE 73
Cdd:PLN00136 11 LGSLAFGVFWMLAVFpsVPFLPIGRTAG--ALLSAVLMIVFHVISPDDAyasidLPILGLLF-------ATMVVGSYLKN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 74 IGFFEWSAIHMVRASKGnGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLGFDKKavfPFIIASGFIADTTSL 153
Cdd:PLN00136 82 AGMFKHLGRLLAWRSQG-GRDLLCRVCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAK---PFLLALASSANIGSS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 154 PLIVSNLVNIVSADYFDFGFVEYFSKmIIPNIFSLIA--SILVLWLYFR---------------------------KSIP 204
Cdd:PLN00136 158 ATPIGNPQNLVIAFNSKITFPKFLLG-ILPAMLAGMAvnMVMLLCMYWKdldggaelsvdgkqmeaveegrspasaKSTK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 205 RKFDAVNIREPK------------EAIKDK------------KLF--NISWIVLTVLLVGYLISefINIPVSIIAGIIAL 258
Cdd:PLN00136 237 QQSPALLQAGLNgdgngdmssmmsENISTKhpwfmqctehrrKLFlkSFAYVVTVGMVVAYMVG--LNMSWTAITTAIAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 259 IFVLLARKSKAVHTkqvikgAPWNIVLFSIGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFLSSIMNN 338
Cdd:PLN00136 315 VVVDFRDAEPCLDT------VSYSLLVFFSGMFITVSGFNKTGLPGAIWNFMAPYSKVNSVGGISVLSVIILLLSNLASN 388
|
....*.
gi 695599480 339 MPTVLI 344
Cdd:PLN00136 389 VPTVLL 394
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
3-131 |
5.99e-05 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 44.94 E-value: 5.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLI-FVIWQPKGLDIGITALIGAVVA-IITGVVSFSDVLEvtGIVWNATLTFVAVILISLILDEIGFFEWS 80
Cdd:cd01116 218 LKSLTILTLVIIgFVLHSPLGVSLGWIALLGALLLlLLADKLDFEDVLS--RVEWDTLLFFAGLFVLVGGLEELGIIEWI 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 695599480 81 AIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALILTPIVLAMVRSLG 131
Cdd:cd01116 296 AELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLG 346
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
4-380 |
2.44e-03 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 40.02 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 4 LAITIFILTLIFVIWQPKGLdiGITALIGA-VVAIITGVVSFSDVLEV-----TGIVWnatLTFVAVILiSLILDEIGFF 77
Cdd:TIGR00785 12 LLLAIFVAAIVGWILEPLPL--PVTALLAIpIIAVLLGVLSAFKFKNAlsgfaDPTIW---LFFGAFIL-ATALVKTGLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 78 EWSAIHMVRASKGNGLKMFVYIMFLGAIVAAFFANDGA--ALILTPIVLAMVRSLG----FDKKAVFPFIIASGFIAD-T 150
Cdd:TIGR00785 86 KRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTAraGGILLPIIKSLLPLLGskpeKSPRKIGKYLMLGIAYSAsI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 151 TSLPLIVSNLVNIVSADY------FDFGFVEYFSKMIIPNIFSLIASILVLWLYFRKSIPRKFDAVniREPKEAIKDKKL 224
Cdd:TIGR00785 166 GSSGFLTGSAPNALAAGIlskilgIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLKDEVD--LWAKEELEEMGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 225 FNISWIVLTVLLVGYLISEFINIPVSIIAGIIALIFVLLARKSKAVHTKQVIKG-APWNIVLFSIGMYLVVFGLKNVGIT 303
Cdd:TIGR00785 244 MSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNkVAWNTLILFGGLIGLAGGLKKSGFI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 304 TLLGDVLTNISSyGLFSSIMGMGFISAFLSSIMNNMP----TVLIDAIAIGQSQTTSILKEGMIYANVIGSDLGPKITPI 379
Cdd:TIGR00785 324 KWFSEKLVGILD-GLSPTIAVLVLVVLFYIILYFFASntahTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPY 402
|
.
gi 695599480 380 G 380
Cdd:TIGR00785 403 A 403
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
288-426 |
7.62e-03 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 38.21 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 288 IGMYLVVFGLKNVGITTLLGDVLTNISSYGLFSSIMGMGFISAFLSSIMNNMPTVLI------DAIAIGQSQTTSILKEG 361
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMmlpialSIAAALGSEKRSKFGSA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695599480 362 MIYANVIGSDLGPKITPIGSLATLLWLHVL-TQKGVKISWGTYFKIGIIITIPVLFITLLGLYLTL 426
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLeEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLL 146
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
3-130 |
8.68e-03 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 38.12 E-value: 8.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695599480 3 ILAITIFILTLIFVIWQPKGLDIGITALIGAVVAIITGVVSFSDVLEVTGiVWNATLTFVAVILISLILDEIGFFEWSAI 82
Cdd:pfam00939 271 ALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWKDIVKNKG-AWNTLIWLGGLIMLANGLERSGFIEWLGN 349
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 695599480 83 HMVRASKGNGLKMFVYIMFLGAIVAAFFANDGAALI--LTPIVLAMVRSL 130
Cdd:pfam00939 350 TLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTaaMLPIFAAVAQAI 399
|
|
|