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Conserved domains on  [gi|694154657|gb|AIS61228|]
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GntR family transcriptional regulator [Listeria ivanovii subsp. londoniensis]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-231 5.56e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 227.05  E-value: 5.56e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   1 MLKYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDvENPDADVLqsm 80
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE-PKIEYPLS--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  81 QFMGFSEE--NKHKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGL-RMDIVA 157
Cdd:COG2188   80 RLTSFTEElrARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLlEEDLET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154657 158 SSIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHA 231
Cdd:COG2188  160 GSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-231 5.56e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 227.05  E-value: 5.56e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   1 MLKYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDvENPDADVLqsm 80
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE-PKIEYPLS--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  81 QFMGFSEE--NKHKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGL-RMDIVA 157
Cdd:COG2188   80 RLTSFTEElrARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLlEEDLET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154657 158 SSIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHA 231
Cdd:COG2188  160 GSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
PRK09764 PRK09764
GntR family transcriptional regulator;
3-235 9.49e-47

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 154.99  E-value: 9.49e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDvENPDADVLQsmqF 82
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE-ERVNYDIFQ---L 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  83 MGFSEENKHKNVS--SDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVASSI 160
Cdd:PRK09764  82 TSFDEKLSDRHVDthSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSK 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657 161 YTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR 235
Cdd:PRK09764 162 YHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQR 236
GntR_LSA1692 NF041547
GntR family transcriptional regulator, LSA1692 subfamily;
3-235 6.28e-40

GntR family transcriptional regulator, LSA1692 subfamily;


Pssm-ID: 469432 [Multi-domain]  Cd Length: 233  Bit Score: 137.26  E-value: 6.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVkdVENPDadvLQS--M 80
Cdd:NF041547   2 LYEEVADKIEKRIKDGVYGSHQKLPSEYDLAKEFEVSRLTIRKAIDLLIKQQVLVKDRGKGTYV--MAQQK---IQSgrG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  81 QFMGFSE--ENKHKNVSSDILKFE-IINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVA 157
Cdd:NF041547  77 GLQGFTEaaKAYGKTSHTKVLEFEeLTNYPEEVKEKLELEENEPVWHIERLRFWDDEPMTVEEIYIREKYLPELTEEDFE 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 694154657 158 SSIYTYIESVLgfSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR 235
Cdd:NF041547 157 GSLFELIEKKI--EIAYSHQEIEAVLVDEELSELLKVKVGSPLLLVHSVTYSVDGYPILYDTSYYRADKYTFKNTLYR 232
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-228 9.09e-39

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 131.26  E-value: 9.09e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657    91 HKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVASSIYTYIESVLGF 170
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694154657   171 SIQ---SAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYE 228
Cdd:smart00866  83 KIVrstRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 3-229 2.23e-37

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 130.56  E-value: 2.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657    3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENpdadvlqsMQF 82
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQ--------IEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   83 -----MGFSEENK--HKNVSSDILKFEIINPDEATLNKL-RISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMD 154
Cdd:TIGR02404  73 pisgiTSFKELNEtlGLDSKTEVVELDKEDPLPETLAQLtGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657  155 IVASSIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEF 229
Cdd:TIGR02404 153 IAEDSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKF 227
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-228 4.25e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.94  E-value: 4.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   91 HKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGL-RMDIVASSIYTYIESVLG 169
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLlEEDLEEGSLYDYLEERYG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 694154657  170 FSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYE 228
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-67 9.84e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.20  E-value: 9.84e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVK 67
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-231 5.56e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 227.05  E-value: 5.56e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   1 MLKYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDvENPDADVLqsm 80
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE-PKIEYPLS--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  81 QFMGFSEE--NKHKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGL-RMDIVA 157
Cdd:COG2188   80 RLTSFTEElrARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLlEEDLET 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154657 158 SSIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHA 231
Cdd:COG2188  160 GSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
PRK09764 PRK09764
GntR family transcriptional regulator;
3-235 9.49e-47

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 154.99  E-value: 9.49e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDvENPDADVLQsmqF 82
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE-ERVNYDIFQ---L 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  83 MGFSEENKHKNVS--SDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVASSI 160
Cdd:PRK09764  82 TSFDEKLSDRHVDthSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSK 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657 161 YTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR 235
Cdd:PRK09764 162 YHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQR 236
GntR_LSA1692 NF041547
GntR family transcriptional regulator, LSA1692 subfamily;
3-235 6.28e-40

GntR family transcriptional regulator, LSA1692 subfamily;


Pssm-ID: 469432 [Multi-domain]  Cd Length: 233  Bit Score: 137.26  E-value: 6.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVkdVENPDadvLQS--M 80
Cdd:NF041547   2 LYEEVADKIEKRIKDGVYGSHQKLPSEYDLAKEFEVSRLTIRKAIDLLIKQQVLVKDRGKGTYV--MAQQK---IQSgrG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  81 QFMGFSE--ENKHKNVSSDILKFE-IINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVA 157
Cdd:NF041547  77 GLQGFTEaaKAYGKTSHTKVLEFEeLTNYPEEVKEKLELEENEPVWHIERLRFWDDEPMTVEEIYIREKYLPELTEEDFE 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 694154657 158 SSIYTYIESVLgfSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR 235
Cdd:NF041547 157 GSLFELIEKKI--EIAYSHQEIEAVLVDEELSELLKVKVGSPLLLVHSVTYSVDGYPILYDTSYYRADKYTFKNTLYR 232
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-228 9.09e-39

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 131.26  E-value: 9.09e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657    91 HKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVASSIYTYIESVLGF 170
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694154657   171 SIQ---SAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYE 228
Cdd:smart00866  83 KIVrstRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 3-229 2.23e-37

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 130.56  E-value: 2.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657    3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENpdadvlqsMQF 82
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQ--------IEF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   83 -----MGFSEENK--HKNVSSDILKFEIINPDEATLNKL-RISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMD 154
Cdd:TIGR02404  73 pisgiTSFKELNEtlGLDSKTEVVELDKEDPLPETLAQLtGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKE 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657  155 IVASSIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEF 229
Cdd:TIGR02404 153 IAEDSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKF 227
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-228 4.25e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.94  E-value: 4.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   91 HKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGL-RMDIVASSIYTYIESVLG 169
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLlEEDLEEGSLYDYLEERYG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 694154657  170 FSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYE 228
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK11402 PRK11402
transcriptional regulator PhoB;
4-229 1.10e-27

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 105.69  E-value: 1.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVK--DVENPDADVLQSMQ 81
Cdd:PRK11402  11 YATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQsqKVENALLTVSGFTD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  82 FMgfseENKHKNVSSDILKFEIINPDEATlNKLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVAS-SI 160
Cdd:PRK11402  91 FG----VSQGKATKEKVIEQERVSAAPFC-EKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsST 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 694154657 161 YTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEF 229
Cdd:PRK11402 166 YQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-67 9.84e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.20  E-value: 9.84e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVK 67
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 4-229 3.38e-19

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 82.91  E-value: 3.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657    4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDveNPDADVLQSMQfm 83
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAA--RRIDYPLSART-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   84 GFSEENKHKNVSSDILKF----EIINPDEATLnkLRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVAS- 158
Cdd:TIGR02325  86 RFSQNLADQGREPTGELLlsdlEPASAELADA--LGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASg 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694154657  159 SIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLDNGQPFEYSNTKYRADKYEF 229
Cdd:TIGR02325 164 SITDALREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEF 234
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-66 4.76e-16

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 69.95  E-value: 4.76e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154657    3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFV 66
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-88 1.14e-15

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 73.43  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVenPDADVLQSMQFM 83
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREP--SPWALLDPLALL 86


                 ....*
gi 694154657  84 GFSEE 88
Cdd:COG2186   87 LALDD 91
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
4-88 1.23e-15

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 70.21  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPD---------- 73
Cdd:COG1725   12 YEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELleerreefle 91

                         90
                 ....*....|....*...
gi 694154657  74 ---ADVLQSMQFMGFSEE 88
Cdd:COG1725   92 ealRELVAEARRLGLSLE 109
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
7-66 2.03e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 68.37  E-value: 2.03e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657     7 IAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFV 66
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-107 3.28e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 71.01  E-value: 3.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPDADVLQSMQF 82
Cdd:COG1167   13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPAPRAAAA 92

                         90       100
                 ....*....|....*....|....*
gi 694154657  83 MGFSEENKHKNVSSDILKFEIINPD 107
Cdd:COG1167   93 VAAPALRRLLEAAPGVIDLGSGAPD 117
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-205 3.60e-13

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 66.49  E-value: 3.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPDAdvLQSMQFM 83
Cdd:PRK14999  14 YETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSA--LFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  84 GFSEENKHKNVSSDILKFEIINPDEATLNKLRISELDFVYHIIRVRKIDKKPHALEE-CFMPINLISGLRMDIVASSIYT 162
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDrCVNADIAVDYLTQDYRQTTPHA 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 694154657 163 YIESVLGFSiQSAHkTVSAVMPTDFEKEYLAIEDVTPILNIEQ 205
Cdd:PRK14999 172 YLSRIAPLT-EGEH-IVEAVRATAQECAWLTIKEHEPCLLIRR 212
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 3-229 2.64e-12

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 64.03  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   3 KYETIAFDLRKKiLSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFV--KDVENP-DADVLQS 79
Cdd:PRK10079  13 RYQEIAAKLEQE-LRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVlmRPYDYPlNAQARFS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657  80 MQFMgfsEENKHKnvSSDILkFEIINPDEATLNK-LRISELDFVYHIIRVRKIDKKPHALEECFMPINLISGLRMDIVAS 158
Cdd:PRK10079  92 QNLL---DQGSHP--TSEKL-LSVLRPASGHVADaLGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQRFDSG 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 694154657 159 SIYTYIESVLGFSIQSAHKTVSAVMPTDFEKEYLAIEDVTPILNIEQVAYLD-NGQPFEYSNTKYRADKYEF 229
Cdd:PRK10079 166 SLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDgESSPAEYSVSLTRADMIEF 237
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-69 1.37e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 56.08  E-value: 1.37e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694154657   5 ETIAFDLRKKILSGFYKQNDQLPlEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDV 69
Cdd:COG1802   14 EQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL 77
PRK10225 PRK10225
Uxu operon transcriptional regulator;
4-72 3.01e-09

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 55.80  E-value: 3.01e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENP 72
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGS 79
PRK11523 PRK11523
transcriptional regulator ExuR;
4-125 3.74e-08

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 52.54  E-value: 3.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154657   4 YETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFV-----KDVENPDADV-- 76
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsnqpRHQQAADNNMef 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 694154657  77 --------LQSMQFM--GFSEENKHKNVSSDILKFEIINPDEATLNKLRISELDFVYHI 125
Cdd:PRK11523  90 anygpfelLQARQLIesNIAEFAATQVTKQDIMKLMAIQEQARGEDCFRDSEWDLQFHV 148
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 7-67 1.26e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 47.84  E-value: 1.26e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694154657   7 IAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVK 67
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
5-68 2.26e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 47.32  E-value: 2.26e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154657   5 ETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKD 68
Cdd:PRK09464  13 DVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 9-74 1.50e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 39.26  E-value: 1.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 694154657   9 FD-LRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPDA 74
Cdd:PRK15481  11 FDsIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVA 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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