|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
2-348 |
9.39e-122 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 357.24 E-value: 9.39e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVECVKRGLdPLKAKLVVMSNADRAgglVLAASPMMKKIHrIKTTSRMYEVPTWDEE--IIIAPPRMKLY 79
Cdd:cd01700 1 ALVDCNSFYASCERVFRPL-LLGRPLVVLSNNDGC---VIARSPEAKALG-IKMGSPYFKVPDLLERhgVAVFSSNYALY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 80 LKVNAMIQAIFLRYVPKefFFPYSIDEAFLDVTGSHAlFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALDNAA 159
Cdd:cd01700 76 GDMSRRIMSILERFSPD--VEVYSIDESFLDLTGSLR-FGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 160 KHQ-TDGIANWRYENVPDTIWKIKELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHGIDYS 238
Cdd:cd01700 153 KKNpYGGVVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 239 KInERYVPVSKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYskysikSGFRHQLKID---- 314
Cdd:cd01700 233 PL-EEYPPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGT------SGFSRQPKYYsatn 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 694154654 315 ----ATSSNRELVGHFLTLFWK-YYENEAVRQVELSCGG 348
Cdd:cd01700 306 tlpyPTNDTREIVKAALRLLYAiYRPGYAYRKAGVMLSD 344
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
2-403 |
6.28e-100 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 303.85 E-value: 6.28e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVEcvkRGLDP-LKAK-LVVMSNADRAGGLVLAASPMMKKiHRIKTTSRMYEVPTWDEEIIIAPPRMKLY 79
Cdd:PRK03103 6 LLVDMQSFYASVE---KAANPeLKGRpVIVSGDPERRSGVVLAACPLAKA-YGVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 80 LKVNAMIQAIFLRYVPK-EfffPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALDNA 158
Cdd:PRK03103 82 IDVSLQITRILEDFTDLvE---PFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 159 AKHQTDGIANWRYENVPDTIWKiKELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHGIDYS 238
Cdd:PRK03103 159 AKKNPDGLFTLDKEDVPADLWP-LPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 239 KINERYVPVSKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKYSIKSGFRHQLKI-DATS 317
Cdd:PRK03103 238 PVTPHSLDRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQMTLpEPTN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 318 SNRELVGHFLTLFWKYYENEAVRQVELSCGGIIQKAGLQLNLFENPVQtvnQEQLDVTIDKIRARYGFKSMMHASSlLTG 397
Cdd:PRK03103 318 LAMEVYEAACKLFHRHWDGKPVRRVGVTLSNLVSDDVWQLSLFGDRER---KRSLGYVMDDIKNRFGPTAILRASS-LTE 393
|
....*.
gi 694154654 398 ATGLKR 403
Cdd:PRK03103 394 AGQAFE 399
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
2-346 |
1.11e-75 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 238.89 E-value: 1.11e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVECVKRGLdpLKAK-LVVMSNADRagGLVLAASPMMKK--IHrikttSRMyevPTWD-----EEIIIAP 73
Cdd:COG0389 4 LHVDMDAFYASVEQRDRPE--LRGKpVAVGGDNNR--GVVAAASYEARAfgVR-----SGM---PLFQarrlcPDLVVLP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 74 PRMKLYLKVNAMIQAIFLRYVPK-EfffPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSK 152
Cdd:COG0389 72 PDFELYRDVSRRVMAILERYTPLvE---PLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 153 LALDnAAKhqTDGIANWRYENVPDTIWKIKeLTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHS 232
Cdd:COG0389 149 IASD-LAK--PDGLTVIPPGEVAAFLAPLP-VEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 233 HGIDYSKINERYVPvsKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKYSIKSgfrHQLK 312
Cdd:COG0389 225 RGIDPRPVEPRRPR--KSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTT---RSRT 299
|
330 340 350
....*....|....*....|....*....|....*.
gi 694154654 313 ID-ATSSNRELVGHFLTLFWKYY-ENEAVRQVELSC 346
Cdd:COG0389 300 LPePTDDTAELLRAARELLERIYrPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
2-340 |
7.89e-64 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 208.14 E-value: 7.89e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVECVKrglDP-LKAK-LVVMSNADRagGLVLAASpmmkkihrikttsrmYEV---------PTWD---- 66
Cdd:cd03586 1 IHIDMDAFYASVEQRD---NPeLKGKpVAVGGSSDR--GVVSTAS---------------YEArkfgvrsamPIFQakkl 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 67 -EEIIIAPPRMKLYLKVNAMIQAIFLRYVPKefFFPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIG 145
Cdd:cd03586 61 cPNLIFVPPRFDKYREVSRQIMEILREYTPL--VEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 146 DNMLLSKLALDNaAKhqTDGIANWRYENVPDTIWKIKeLTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIG 225
Cdd:cd03586 139 PNKFLAKIASDL-NK--PNGLTVIPPEDVEEFLAPLP-VRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 226 EQLYYHSHGIDYSKINERYVPvsKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKYSIKS 305
Cdd:cd03586 215 RRLYELARGIDNRPVEPDRER--KSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRT 292
|
330 340 350
....*....|....*....|....*....|....*.
gi 694154654 306 gfrHQLKID-ATSSNRELVGHFLTLFWKYYENEAVR 340
Cdd:cd03586 293 ---RSRTLPePTDDAEDIYELALELLEELLDGRPIR 325
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
4-384 |
8.47e-49 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 170.98 E-value: 8.47e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 4 IDVKSFFASVECVKrglDP-LKAK-LVVMSNADRAGGLVLAASPMMKKiHRIKTTsrmyeVPTWDE-----EIIIAPPRM 76
Cdd:PRK01810 10 VDMNSFFASVEIAY---DPsLQGKpLAVAGNEKERKGIIVTCSYEARA-YGIRTT-----MPLWEAkrlcpQLIVRRPNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 77 KLYLKVNAMIQAIFLRYVPKefFFPYSIDEAFLDVTGSHALfGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALD 156
Cdd:PRK01810 81 DRYREASRQMFQILSEFTPL--VQPVSIDEGYLDITDCYAL-GSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 157 naaKHQTDGIANWRYENVPDTIWKIkELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHGID 236
Cdd:PRK01810 158 ---MKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGID 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 237 YSKINERYVPVSKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYskYSIKSGFRHQLKIDAT 316
Cdd:PRK01810 234 DRPVDPEAIYQFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRY--HDRRTITRSKTLKNPI 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 317 SSNRELVGHFLTLFWKYYENEAVRQVELSCGGIIQK--AGLQLNLFENPvQTVNQEQLDVTIDKIRARYG 384
Cdd:PRK01810 312 WEKRDIFQAASRLFKQHWNGDPVRLLGVTATDLEWKteAVKQLDLFSFE-EDAKEEPLLAVIDQINDKYG 380
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
2-298 |
7.88e-38 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 140.19 E-value: 7.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVECVKRGLdpLKAKLVVMSNADRAGGLVLAASPMMKKIHrIKTTSRMYE----VPtwdeEIIIAPPRMK 77
Cdd:cd00424 1 LHIDFDNFFASVEQLARPE--LKGRPVVVVPFNSDSTCVIACSYEARKYG-VKRGMPVREarkmCP----NLILVPARLD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 78 LYLKVNAMIQAIFLRYVPKEFffPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLF-VTVGIGDNMLLSKLALD 156
Cdd:cd00424 74 LYRRLSERLLSELEEVAPLVE--VASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGGItASIGIASNKLLAKLAAK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 157 nAAKhqTDGIANWRYENVPDTIWKIKeLTDMWGIGHRTAENLKRLGIFSVYALSQSPP-PLLKRRLGVIGEQLYYHSHGI 235
Cdd:cd00424 152 -YAK--PDGLTILDPEDLPGFLSKLP-LTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGI 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 694154654 236 DYSKINERyvPVSKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRY 298
Cdd:cd00424 228 DDEPLSPP--RPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRT 288
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
70-286 |
9.05e-37 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 137.17 E-value: 9.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 70 IIAPPRMKLYLKVNAMIQAIFLRYVPK-EfffPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNM 148
Cdd:PRK02406 62 IFVPGRFDVYKEVSRQIREIFRRYTDLiE---PLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 149 LLSKLALDnaaKHQTDGIANWRYENVPDTiwkIKEL--TDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGE 226
Cdd:PRK02406 139 FLAKIASD---WNKPNGLFVITPEEVDAF---LATLpvEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGR 212
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694154654 227 QLYYHSHGIDYSKIN-ERyvpVSKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHH 286
Cdd:PRK02406 213 RLYERARGIDERPVKpDR---ERKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERAK 270
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
4-156 |
1.40e-36 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 130.77 E-value: 1.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 4 IDVKSFFASVEcvkRGLDP-LKAKLVVMSNADRaGGLVLAASPMMKKiHRIKTTSRMYEVPTWDEEIIIAPPRMKLYLKV 82
Cdd:pfam00817 1 IDMDAFFASVE---LLRDPeLKGKPVAVGGGNG-RGIVAAASYEARK-YGVRSGMPVFEAKKLCPNLIVVPPDLELYRRA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 694154654 83 NAMIQAIFLRYVPKEFFfPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALD 156
Cdd:pfam00817 76 SRKIFEILRRFSTPKVE-QASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-401 |
2.44e-33 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 128.95 E-value: 2.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 5 DVKSFFASVEcvKRgLDP-LKAKLVVMsnadrAGGLVLAASpMMKKIHRIKTTSRMYEVPTWDEEIIIAPPRMKLYLKVN 83
Cdd:PRK03858 10 DLDSFYASVE--QR-DDPaLRGRPVIV-----GGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 84 AMIQAIFLRYVPkeFFFPYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLAldnAAKHQT 163
Cdd:PRK03858 81 KAVFEVFRDTTP--LVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVA---SQVAKP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 164 DGIanwrYENVPDTiwkikELT--------DMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLG-VIGEQLYYHSHG 234
Cdd:PRK03858 156 DGL----LVVPPDR-----ELAflhplpvrRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGpAAGRHLHALAHN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 235 IDyskinERYVPVSK---SYGKSQILERDYHDPFEVAIVIREMAEEIAMRLR-KHHVNTTVVhIGIRYSKYSikSGFRHQ 310
Cdd:PRK03858 227 RD-----PRRVETGRrrrSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRaAGRTGRTVV-LRLRFDDFT--RATRSH 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 311 LKIDATSSN-------RELVGHFLTLFwkyyENEAVRQVELSCGGIIQKAGLQLNL-FENPVQTVnqeQLDVTIDKIRAR 382
Cdd:PRK03858 299 TLPRPTASTatllaaaRDLVAAAAPLI----AERGLTLVGFAVSNLDDDGAQQLELpFGLRRPGS---ALDAALDAVRDR 371
|
410
....*....|....*....
gi 694154654 383 YGFKSMMHAsSLLTGATGL 401
Cdd:PRK03858 372 FGNAAVTRA-VLLGRDPGL 389
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
4-301 |
9.92e-25 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 104.03 E-value: 9.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 4 IDVKSFFASVEcvKRGLDPLKAKLVVMSN-ADRagGLVLAASPMMKKiHRIKTTSRMYEVPTWDEEIIIAPPRMKLYLKV 82
Cdd:PRK14133 8 VDMDAFFASVE--QMDNPKLKGKPVIVGGiSER--GVVSTCSYEARK-YGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 83 NAMIQAIFLRYVPkeFFFPYSIDEAFLDVTGSHAlfgSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALDnaaKHQ 162
Cdd:PRK14133 83 SKNIFKILYEVTP--IVEPVSIDEAYLDITNIKE---EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASD---WNK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 163 TDGIANWRYENVPDtIWKIKELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHGIDyskinE 242
Cdd:PRK14133 155 PDGIKIITEDMIPD-ILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGID-----Y 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 694154654 243 RYVPVS---KSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKY 301
Cdd:PRK14133 229 REVEVSrerKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDF 290
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-323 |
2.51e-23 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 100.10 E-value: 2.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 1 MLCIDVKSFFASVECVKR----GL--------DPLKAKLVVM--SNADRAGGlVLAASPMmkkihriKTTSRmyEVPtwd 66
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRpelaGLpvivggngDPTEPRKVVTcaSYEARAFG-VRAGMPL-------RTAAR--RCP--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 67 eEIIIAPPRMKLYLKVNAMIQAIfLRYvpkeffFPYSI-----DEAFLDVTGSHAlfgstQEIAERIQADILRELRLFVT 141
Cdd:PRK03352 74 -DAVFLPSDPAAYDAASEEVMAT-LRD------LGVPVevwgwDEAFLGVDTDDP-----EALAEEIRAAVLERTGLSCS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 142 VGIGDNMLLSKLALD---NAAKHQTDGiANWryenvpdtiWKI---KELTDMWGIGHRTAENLKRLGIFSVYALSQSPPP 215
Cdd:PRK03352 141 VGIGDNKLRAKIATGfakPAGVFRLTD-ANW---------MAVmgdRPTDALWGVGPKTAKRLAALGITTVADLAAADPA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 216 LLKRRLG-VIGEQLYYHSHGIDYSKIN-ERYVPVSKSygKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVH 293
Cdd:PRK03352 211 ELAATFGpTTGPWLLLLARGGGDTEVSaEPWVPRSRS--REVTFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVA 288
|
330 340 350
....*....|....*....|....*....|
gi 694154654 294 IGIRYSKYSIKSgfrHQLKIDATSSNRELV 323
Cdd:PRK03352 289 VKVRTATFYTRT---KIRKLPEPTTDPDVI 315
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-284 |
7.11e-22 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 96.92 E-value: 7.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 4 IDVKSFFASVEcvKRGlDP-LKAKLVVMSNADRagGLVLAASpMMKKIHRIKTTSRMYEVPTWDEEIIIAPPRMKLYLKV 82
Cdd:PRK02794 41 IDCDAFYASVE--KRD-NPeLRDKPVIIGGGKR--GVVSTAC-YIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 83 NAMIQAIFLRYVPkeFFFPYSIDEAFLDVTGSHALFG-STQEIAERIQADILRELRLFVTVGIGDNMLLSKLA--LDNAA 159
Cdd:PRK02794 115 GREVRAMMQALTP--LVEPLSIDEAFLDLSGTERLHGaPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIAsdLDKPR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 160 KHQTDGIANWRyenvpdTIWKIKELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHGIDYSK 239
Cdd:PRK02794 193 GFSVIGRAEAL------AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRK 266
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 694154654 240 IN-ERYVpvsKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRK 284
Cdd:PRK02794 267 VSpDREA---KSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKA 309
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
2-285 |
1.13e-19 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 90.76 E-value: 1.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCIDVKSFFASVECVKRgldP-LKAKLVVMsnadraGGL----VLA-------------ASPMMKKIHRIKTTSrmyevp 63
Cdd:PRK03348 8 LHLDMDAFFASVEQLTR---PtLRGRPVLV------GGLggrgVVAgasyearvfgarsAMPMHQARRLVGNGA------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 64 twdeeiIIAPPRMKLYLKVNAMIQAIFLRYVPK-EfffPYSIDEAFLDVTGshaLFGST----QEIAERIQADILRELRL 138
Cdd:PRK03348 73 ------VVLPPRFVVYRAASRRVFDTLRELSPVvE---QLSFDEAFVEPAE---LAGASaeevEAFAERLRARVREETGL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 139 FVTVGIGDNMLLSKLALDNAakhQTDGIANwryenVP--DTIWKIKEL--TDMWGIGHRTAENLKRLGIFSVYALSQSPP 214
Cdd:PRK03348 141 PASVGAGSGKQIAKIASGLA---KPDGIRV-----VPpgEERELLAPLpvRRLWGIGPVTEEKLHRLGIETIGDLAALSE 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 694154654 215 PLLKRRLG-VIGEQLYYHSHGIDyskinERyvPVSKSYGKSQI-----LERDYHDPFEVAIVIREMAEEIAMRLRKH 285
Cdd:PRK03348 213 AEVANLLGaTVGPALHRLARGID-----DR--PVAERAEAKQIsaestFAVDLTTRAQLREAIERIAEHAHRRLLKD 282
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
2-413 |
4.02e-18 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 85.97 E-value: 4.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 2 LCiDVKSFFASVECVKRgldP-LKAK-LVVMSNADragGLVLAASPMMKKIHrIKTTSRMYEVPT--WDEEIIIAPPRMK 77
Cdd:PRK03609 4 LC-DVNSFYASCETVFR---PdLRGKpVVVLSNND---GCVIARSAEAKALG-IKMGDPWFKQKDlfRRCGVVCFSSNYE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 78 LYLKVNAMIQAIFLRYVPKefFFPYSIDEAFLDVTGSHALFGSTqEIAERIQADILRELRLFVTVGIGDNMLLSKLAlDN 157
Cdd:PRK03609 76 LYADMSNRVMSTLEELSPR--VEIYSIDEAFCDLTGVRNCRDLT-DFGREIRATVLQRTHLTVGVGIAQTKTLAKLA-NH 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 158 AAKH---QTDGIANWRYENVPDTIWKIKELTDMWGIGHRTAENLKRLGIFSVYALSQSPPPLLKRRLGVIGEQLYYHSHG 234
Cdd:PRK03609 152 AAKKwqrQTGGVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 235 IDYSKInERYVPV------SKSYGksqilER--DYHdpfEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKYSIKS- 305
Cdd:PRK03609 232 EPCLSL-EEFAPTkqeivcSRSFG-----ERitDYE---SMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEp 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 306 --GFRHQLKI-DATSSNRELVghfltlfwkyyeNEAVRQVE--LSCGGIIQKAGL-----------QLNLFENPVQTVNQ 369
Cdd:PRK03609 303 yyGNSASVKLlTPTQDSRDII------------AAATRALDaiWRDGHRYQKAGVmlgdffsqgvaQLNLFDDNAPRPGS 370
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 694154654 370 EQLDVTIDKIRARYGFKSMMHASSLLTGATGLKR---SDIYSTLSRD 413
Cdd:PRK03609 371 EQLMKVLDTLNAKSGKGTLYFAGQGIAQQWQMKRemlSPRYTTRWSD 417
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-203 |
1.10e-16 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 80.99 E-value: 1.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 1 MLCIDVKSFFASVECVkrgLDP-LKAKLVVM---SNADRAGGLVLAASPMMKKIHrIKTTSRMYEVPTWDEEIIIAPPRM 76
Cdd:PRK01216 3 ILFVDFDYFFAQVEEV---LNPsLKGKPVVVcvySGRFEDSGAVATANYEARKLG-IKAGMPIVEAKKILPNAVYLPMRK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 77 KLYLKVNAMIQAIFLRYVPK-EFffpYSIDEAFLDVTGSHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLAL 155
Cdd:PRK01216 79 EVYQQVSNRIMKLLREYSEKiEI---ASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 694154654 156 DNAakhQTDGIANWRYENVPDTIWKIKeLTDMWGIGHRTAENLKRLGI 203
Cdd:PRK01216 156 DMA---KPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGV 199
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
90-284 |
1.57e-16 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 80.82 E-value: 1.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 90 FLRYVPKEFFF------------PYSIDEAFLDVTG-SHALFGSTQEIAERIQADILRELRLFVTVGIGDNMLLSKLALD 156
Cdd:cd01701 121 FEAYEEVSLTFyeilasytdnieAVSCDEALIDITSlLEETYELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATR 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 157 NAakhQTDGIANWRYENVPDTIWKIKeLTDMWGIGHRTAENLKRLGIFSVYALSQSPPPL--LKRRLGVI-GEQLYYHSH 233
Cdd:cd01701 201 KA---KPDGQYHLSAEKVEEFLSQLK-VGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKekLQKVLGPKtGEKLYDYCR 276
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 694154654 234 GIDYSKINE----RYVPVSKSYGKSqilerdYHDPFEVAIVIREMAEEIAMRLRK 284
Cdd:cd01701 277 GIDDRPVTGekerKSVSAEINYGIR------FTNVDDVEQFLQRLSEELSKRLEE 325
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
248-353 |
4.86e-16 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 73.36 E-value: 4.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 248 SKSYGKSQILERDYHDPFEVAIVIREMAEEIAMRLRKHHVNTTVVHIGIRYSKYsikSGFRHQLKID-ATSSNRELVGHF 326
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDF---RTITRSVTLPsPTDDTDEIYRAA 77
|
90 100
....*....|....*....|....*..
gi 694154654 327 LTLFWKYYENEAVRQVELSCGGIIQKA 353
Cdd:pfam11799 78 LRLLRRLYRGRPVRLLGVSLSNLVPEG 104
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
4-333 |
2.14e-15 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 76.97 E-value: 2.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 4 IDVKSFFASVECVKRGL---DPLKA----KLVVMSNADRAGGL-----VLAASPMMKKIHRIKT-TSRMYEVpTWDEEII 70
Cdd:cd01702 3 IDMDAFFAQVEQVRLGLlrnDPVAVvqwnSIIAVSYAARAFGVtrfmtIDEAKKKCPDLILAHVaTYKKGED-EADYHEN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 71 IAPPRMKL----YLKVNAMIQAIFLRY---VPKEfffpySIDEAFLDVTGshalfgstqEIAERIQADILRELRLFVTVG 143
Cdd:cd01702 82 PSPARHKVsldpYRRASRKILNILKRFgdvVEKA-----SIDEAYLDLGS---------RIVEEIRQQVYDELGYTCSAG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 144 IGDNMLLSKLAldnAAKHQTDGIANWRYENVPDTIWKiKELTDMWGIGHRTAENLK-RLGIFSVYALSQ--SPPPLLKRR 220
Cdd:cd01702 148 IAHNKMLAKLA---SGMNKPNAQTILRNDAVASFLSS-LPITSIRGLGGKLGEEIIdLLGLPTEGDVAGfrSSESDLQEH 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 221 LGV-IGEQLYYHSHGIDYSKINERyvPVSKSYGKSQILERDYHDPFEVAIV-IREMAEEIAMRLRKHHVN------TTVV 292
Cdd:cd01702 224 FGEkLGEWLYNLLRGIDHEPVKPR--PLPKSMGSSKNFPGKTALSTEDVQHwLLVLASELNSRLEDDRYEnnrrpkTLVL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 694154654 293 HIG--IRYSKYSIKSGFR----HQLKIDATSSNRELVGHFLTLFWKY 333
Cdd:cd01702 302 SLRqrGDGVRRSRSCALPrydaQKIVKDAFKLIKAINEEGLGLAWNY 348
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
5-295 |
2.17e-08 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 55.55 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 5 DVKSFFASVECVKrglDP-LKAK--------LVVMSN--ADRAGglvlaaspmMKKIHRIKTTSRMyeVPtwdEEIIIAP 73
Cdd:cd01703 4 DLDCFYAQVEEIR---DPsLKSKplgiqqkyIVVTCNyeARRLG---------VKKLMSIKDAKEI--CP---DLVLVNG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 74 PRMKLYLKVNAMIQAIFLRYVPKEFFFPYSIDEAFLDVTGSHALFGStqEIAERIQADILRELRLFVTVGIGDNMLLSKL 153
Cdd:cd01703 67 EDLTPFRDMSKKVYRLLRSYSWNDRVERLGFDENFMDVTEMRLLVAS--HIAYEMRERIENELGLTCCAGIASNKLLAKL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 154 -ALDNAAKHQTDGIAnwryeNVPDTIWKIKELTDMW---GIGHRTAENLKRLGIFSVYALSQSP----------PPLLKR 219
Cdd:cd01703 145 vGSVNKPNQQTTLLP-----PSCADLMDFMDLHDLRkipGIGYKTAAKLEAHGISSVRDLQEFSnrnrqtvgaaPSLLEL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694154654 220 RLGV------IGEQLYYHSHGIDYSkineryvPVSKSYGK-SQILERD---YHDPFEVAIVIREMAEEIAMRLRKHHVNT 289
Cdd:cd01703 220 LLMVkefgegIGQRIWKLLFGRDTS-------PVKPASDFpQQISIEDsykKCSLEEIREARNKIEELLASLLERMKQDL 292
|
....*.
gi 694154654 290 TVVHIG 295
Cdd:cd01703 293 QEVKAG 298
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
171-203 |
3.00e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 40.84 E-value: 3.00e-05
10 20 30
....*....|....*....|....*....|...
gi 694154654 171 YENVPDTIWKIKeLTDMWGIGHRTAENLKRLGI 203
Cdd:pfam11798 1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
86-154 |
1.98e-04 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 43.14 E-value: 1.98e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 694154654 86 IQAIFLRYVPKEFFFPYsiDEAFLDVTGSHALFGSTQEIAERIQADiLRELRLFVTVGIGDNMLLSKLA 154
Cdd:cd03468 81 LALWLLRFTPLVALDGP--DGLLLDVTGCLHLFGGEDALAASLRAA-LATLGLSARAGIADTPGAAWLL 146
|
|
| |
