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Conserved domains on  [gi|694095094|ref|WP_032439674|]
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MULTISPECIES: EAL domain-containing protein [Klebsiella/Raoultella group]

Protein Classification

EAL domain-containing protein( domain architecture ID 10112612)

EAL domain-containing protein may act as a cyclic diguanylate phosphodiesterase

PubMed:  28186120|20691189|25447517

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjcC super family cl34845
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 1-268 7.81e-93

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4943:

Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 283.73  E-value: 7.81e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   1 MLLVTVSLL-SGLMIYILIMNRAELNSsLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFI 79
Cdd:COG4943  245 LLLLPLGLLlSLLLGLLVLRLLRRRLS-PRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVISPDIFI 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  80 PLSEREGLQEDVTLFVINHAIREFIHTAIQN-EIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQGGDF 158
Cdd:COG4943  324 PLAEQSGLISPLTRQVIEQVFRDLGDLLAADpDFHISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEITERGFIDP 403

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 159 EGMKIHIDKYKNHGVRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVE 238
Cdd:COG4943  404 AKARAVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNLDVVAEGVE 483

                        250       260       270
                 ....*....|....*....|....*....|
gi 694095094 239 TQEQVNYLKTFWPQsYAQGWYYSRALPLEE 268
Cdd:COG4943  484 TEEQADYLRARGVQ-YGQGWLFAKPLPAEE 512
 
Name Accession Description Interval E-value
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 1-268 7.81e-93

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 283.73  E-value: 7.81e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   1 MLLVTVSLL-SGLMIYILIMNRAELNSsLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFI 79
Cdd:COG4943  245 LLLLPLGLLlSLLLGLLVLRLLRRRLS-PRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVISPDIFI 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  80 PLSEREGLQEDVTLFVINHAIREFIHTAIQN-EIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQGGDF 158
Cdd:COG4943  324 PLAEQSGLISPLTRQVIEQVFRDLGDLLAADpDFHISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEITERGFIDP 403

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 159 EGMKIHIDKYKNHGVRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVE 238
Cdd:COG4943  404 AKARAVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNLDVVAEGVE 483

                        250       260       270
                 ....*....|....*....|....*....|
gi 694095094 239 TQEQVNYLKTFWPQsYAQGWYYSRALPLEE 268
Cdd:COG4943  484 TEEQADYLRARGVQ-YGQGWLFAKPLPAEE 512
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 30-268 1.12e-73

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 225.50  E-value: 1.12e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  30 ARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFI-HTAI 108
Cdd:cd01948    1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLArWQAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 109 QNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQ-GGDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNL 187
Cdd:cd01948   81 GPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESAlIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 188 NLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTfWPQSYAQGWYYSRALPLE 267
Cdd:cd01948  161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRE-LGCDYVQGYLFSRPLPAE 239


                 .
gi 694095094 268 E 268
Cdd:cd01948  240 E 240
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 34-268 3.75e-68

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 211.31  E-value: 3.75e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094    34 KALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHA---IREFIHTAIQN 110
Cdd:smart00052   6 QALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQAcqqLAEWQAQGPPP 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   111 eIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNLNL 189
Cdd:smart00052  86 -LLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLlDDDESAVATLQRLRELGVRIALDDFGTGYSSLSY 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 694095094   190 VAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFWPQsYAQGWYYSRALPLEE 268
Cdd:smart00052 165 LKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCD-YGQGYLFSRPLPLDD 242
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 30-263 5.36e-59

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 187.91  E-value: 5.36e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   30 ARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFIHTAIQ 109
Cdd:pfam00563   2 RALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  110 NEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNLN 188
Cdd:pfam00563  82 PDIKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLlARLEALREVLKRLRALGIRIALDDFGTGYSSLS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694095094  189 LVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTfWPQSYAQGWYYSRA 263
Cdd:pfam00563 162 YLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRE-LGCDLVQGYYFSKP 235
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 22-268 5.40e-39

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 144.91  E-value: 5.40e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  22 AELNSSLSARFV------KALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFV 95
Cdd:PRK11359 532 PAMNEMVKERLVlgaalkEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWV 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  96 INHAIREFI--HTAIQNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQGGDF-EGMKIHIDKYKNHG 172
Cdd:PRK11359 612 IAEACRQLAewRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMMEHdTEIFKRIQILRDMG 691

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 173 VRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFwPQ 252
Cdd:PRK11359 692 VGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKI-HC 770

                        250
                 ....*....|....*.
gi 694095094 253 SYAQGWYYSRALPLEE 268
Cdd:PRK11359 771 RVIQGYFFSRPLPAEE 786
 
Name Accession Description Interval E-value
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 1-268 7.81e-93

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 283.73  E-value: 7.81e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   1 MLLVTVSLL-SGLMIYILIMNRAELNSsLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFI 79
Cdd:COG4943  245 LLLLPLGLLlSLLLGLLVLRLLRRRLS-PRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVISPDIFI 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  80 PLSEREGLQEDVTLFVINHAIREFIHTAIQN-EIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQGGDF 158
Cdd:COG4943  324 PLAEQSGLISPLTRQVIEQVFRDLGDLLAADpDFHISINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEITERGFIDP 403

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 159 EGMKIHIDKYKNHGVRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVE 238
Cdd:COG4943  404 AKARAVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNLDVVAEGVE 483

                        250       260       270
                 ....*....|....*....|....*....|
gi 694095094 239 TQEQVNYLKTFWPQsYAQGWYYSRALPLEE 268
Cdd:COG4943  484 TEEQADYLRARGVQ-YGQGWLFAKPLPAEE 512
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 30-268 1.12e-73

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 225.50  E-value: 1.12e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  30 ARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFI-HTAI 108
Cdd:cd01948    1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLArWQAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 109 QNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQ-GGDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNL 187
Cdd:cd01948   81 GPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESAlIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 188 NLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTfWPQSYAQGWYYSRALPLE 267
Cdd:cd01948  161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRE-LGCDYVQGYLFSRPLPAE 239


                 .
gi 694095094 268 E 268
Cdd:cd01948  240 E 240
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 19-272 1.22e-69

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 225.05  E-value: 1.22e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  19 MNRAELNSSLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINH 98
Cdd:COG2200  320 EARARRRLALESELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWRHPDGGLISPAEFIPAAERSGLIVELDRWVLER 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  99 AIREFIHTAIQN-EIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVRFA 176
Cdd:COG2200  400 ALRQLARWPERGlDLRLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALlEDLEAAIELLARLRALGVRIA 479

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 177 IDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKtfwpQS--- 253
Cdd:COG2200  480 LDDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALR----ELgcd 555

                        250
                 ....*....|....*....
gi 694095094 254 YAQGWYYSRALPLEEARKL 272
Cdd:COG2200  556 YAQGYLFGRPLPLEELEAL 574
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 34-268 3.75e-68

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 211.31  E-value: 3.75e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094    34 KALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHA---IREFIHTAIQN 110
Cdd:smart00052   6 QALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQAcqqLAEWQAQGPPP 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   111 eIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNLNL 189
Cdd:smart00052  86 -LLISINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLlDDDESAVATLQRLRELGVRIALDDFGTGYSSLSY 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 694095094   190 VAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFWPQsYAQGWYYSRALPLEE 268
Cdd:smart00052 165 LKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCD-YGQGYLFSRPLPLDD 242
COG5001 COG5001
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ...
 19-272 5.90e-60

Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];


Pssm-ID: 444025 [Multi-domain]  Cd Length: 678  Bit Score: 201.54  E-value: 5.90e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  19 MN-RAELNSSLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVIN 97
Cdd:COG5001  416 MDeRARERLELEADLRRALERGELELHYQPQVDLATGRIVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLR 495

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  98 HAIREF--IHTAIQNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVR 174
Cdd:COG5001  496 EACRQLaaWQDAGLPDLRVAVNLSARQLRDPDLVDRVRRALAETGLPPSRLELEITESALlEDPEEALETLRALRALGVR 575

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 175 FAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTEslrydllPGLHEMFRSIAD-------KIVFEGVETQEQVNYLK 247
Cdd:COG5001  576 IALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAED-------PDDAAIVRAIIAlahslglEVVAEGVETEEQLEFLR 648

                        250       260
                 ....*....|....*....|....*
gi 694095094 248 TFWPQsYAQGWYYSRALPLEEARKL 272
Cdd:COG5001  649 ELGCD-YAQGYLFSRPLPAEELEAL 672
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 30-263 5.36e-59

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 187.91  E-value: 5.36e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   30 ARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFIHTAIQ 109
Cdd:pfam00563   2 RALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  110 NEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQG-GDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNLN 188
Cdd:pfam00563  82 PDIKLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLlARLEALREVLKRLRALGIRIALDDFGTGYSSLS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 694095094  189 LVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTfWPQSYAQGWYYSRA 263
Cdd:pfam00563 162 YLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRE-LGCDLVQGYYFSKP 235
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 22-268 5.40e-39

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 144.91  E-value: 5.40e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  22 AELNSSLSARFV------KALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFV 95
Cdd:PRK11359 532 PAMNEMVKERLVlgaalkEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWV 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  96 INHAIREFI--HTAIQNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERQGGDF-EGMKIHIDKYKNHG 172
Cdd:PRK11359 612 IAEACRQLAewRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMMEHdTEIFKRIQILRDMG 691

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 173 VRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFwPQ 252
Cdd:PRK11359 692 VGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKI-HC 770

                        250
                 ....*....|....*.
gi 694095094 253 SYAQGWYYSRALPLEE 268
Cdd:PRK11359 771 RVIQGYFFSRPLPAEE 786
PRK10551 PRK10551
cyclic di-GMP phosphodiesterase;
8-268 5.46e-37

cyclic di-GMP phosphodiesterase;


Pssm-ID: 182541 [Multi-domain]  Cd Length: 518  Bit Score: 137.05  E-value: 5.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   8 LLSGLMIYILIMNRAELNSSLSAR----FVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSE 83
Cdd:PRK10551 240 LLLGLLSGILVGLLCYYLLSLRMRpgkeILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFINYAE 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  84 REGLQEDVT--LFVI----NHAIREFIHTAIQneifLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITERqggd 157
Cdd:PRK10551 320 AQKLIVPLTqhLFELiardAAELQKVLPVGAK----LGINISPAHLHSDSFKADVQRLLASLPADHFQIVLEITER---- 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 158 feGMkihIDKYK---------NHGVRFAIDDFGTGYSNLNLVAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSI 228
Cdd:PRK10551 392 --DM---VQEEEatklfawlhSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRL 466

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 694095094 229 ADKIVFEGVETQEQVNYLKTFwPQSYAQGWYYSRALPLEE 268
Cdd:PRK10551 467 NMLTVAEGVETPEQARWLRER-GVNFLQGYWISRPLPLED 505
PRK11829 PRK11829
biofilm formation regulator HmsP; Provisional
 33-268 2.69e-32

biofilm formation regulator HmsP; Provisional


Pssm-ID: 183329 [Multi-domain]  Cd Length: 660  Bit Score: 125.05  E-value: 2.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  33 VKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFIHTAIQN-E 111
Cdd:PRK11829 411 LQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLEEACRILADWKARGvS 490

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 112 IFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITER-QGGDFEGMKIHIDKYKNHGVRFAIDDFGTGYSNLNLV 190
Cdd:PRK11829 491 LPLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETaQIQDLDEALRLLRELQGLGLLIALDDFGIGYSSLRYL 570

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 191 ---AALDVDEIKIDKSLTSAIGTESlrydllpGLHEMFRSIAD----KIVFEGVETQEQVNYLKTFWPQsYAQGWYYSRA 263
Cdd:PRK11829 571 nhlKSLPIHMIKLDKSFVKNLPEDD-------AIARIISCVSDvlkvRVMAEGVETEEQRQWLLEHGIQ-CGQGFLFSPP 642


                 ....*
gi 694095094 264 LPLEE 268
Cdd:PRK11829 643 LPRAE 647
PRK13561 PRK13561
putative diguanylate cyclase; Provisional
 19-273 8.26e-31

putative diguanylate cyclase; Provisional


Pssm-ID: 184143 [Multi-domain]  Cd Length: 651  Bit Score: 120.97  E-value: 8.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  19 MNRAELNSSLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINH 98
Cdd:PRK13561 392 MEAAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPEGLIDRIESCGLMVTVGHWVLEE 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  99 AIREFIHTAIQN-EIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITE-RQGGDFEGMKIHIDKYKNHGVRFA 176
Cdd:PRK13561 472 SCRLLAAWQERGiMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTEsRRIDDPHAAVAILRPLRNAGVRVA 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 177 IDDFGTGYSNLNLV---AALDVDEIKIDKSLTSAIGTESlryDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFwPQS 253
Cdd:PRK13561 552 LDDFGMGYAGLRQLqhmKSLPIDVLKIDKMFVDGLPEDD---SMVAAIIMLAQSLNLQVIAEGVETEAQRDWLLKA-GVG 627

                        250       260
                 ....*....|....*....|..
gi 694095094 254 YAQGWYYSRALPLE--EARKLT 273
Cdd:PRK13561 628 IAQGFLFARALPIEifEERYLE 649
PRK10060 PRK10060
cyclic di-GMP phosphodiesterase;
34-275 5.76e-22

cyclic di-GMP phosphodiesterase;


Pssm-ID: 236645 [Multi-domain]  Cd Length: 663  Bit Score: 95.13  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  34 KALKNEALSLVYQPIYRIeDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFIHTAIQNeIF 113
Cdd:PRK10060 415 KALENDQLVIHYQPKITW-RGEVRSLEALVRWQSPERGLIPPLEFISYAEESGLIVPLGRWVMLDVVRQVAKWRDKG-IN 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 114 LSVNINPSD---LDSEKFRDkLLGLISEYNIPYKTILLEITERQGGDFEGMKIH-IDKYKNHGVRFAIDDFGTGYSNLNL 189
Cdd:PRK10060 493 LRVAVNVSArqlADQTIFTA-LKQALQELNFEYCPIDVELTESCLIENEELALSvIQQFSQLGAQVHLDDFGTGYSSLSQ 571

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 190 VAALDVDEIKIDKSLTSAIGTESLRYDLLPGLHEMFRSIADKIVFEGVETQEQVNYLKTFwPQSYAQGWYYSRALP---- 265
Cdd:PRK10060 572 LARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKEDAFLTKN-GVNERQGFLFAKPMPavaf 650

                        250
                 ....*....|...
gi 694095094 266 ---LEEARKLTIR 275
Cdd:PRK10060 651 erwYKRYLKRKLI 663
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 27-204 8.58e-11

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 62.38  E-value: 8.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094   27 SLSARFVKALKNEALSLVYQPIYRIEDGQICGFEALLRWKDERLGNINPEVFIPLSEREGLQEDVTLFVINHAIREFIHT 106
Cdd:PRK09776  841 SLAEQWRMIKENQLMMLAHGVASPRIPEARNHWLISLRLWDPEGEIIDEGAFRPAAEDPALMHALDRRVIHEFFRQAAKA 920

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  107 AIQNEIFLSVNINPSDLDSEKFRDKLLGLISEYNIPYKTILLEITER--QGGDFEGMKIhIDKYKNHGVRFAIDDFGTGY 184
Cdd:PRK09776  921 VASKGLSIALPLSVAGLSSPTLLPFLLEQLENSPLPPRLLHLEITETalLNHAESASRL-VQKLRLAGCRVVLSDFGRGL 999

                         170       180
                  ....*....|....*....|
gi 694095094  185 SNLNLVAALDVDEIKIDKSL 204
Cdd:PRK09776 1000 SSFNYLKAFMADYLKLDGEL 1019
PRK11596 PRK11596
cyclic-di-GMP phosphodiesterase; Provisional
 45-275 1.02e-10

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183222 [Multi-domain]  Cd Length: 255  Bit Score: 60.40  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  45 YQPIYRIeDGQICGFEAL--LRWKDERLGNINPEVF---IPLSER-EGLQEDVTLFVINHAIreFIHtaiqNEIFLSVNI 118
Cdd:PRK11596  34 FQPIYRT-SGRLMAIELLtaVTHPSNPSQRLSPERYfaeITVSHRlDVVKEQLDLLAQWADF--FVR----HGLLASVNI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 119 NPSDLDSEKFRDKLLGLISEynIPYktILLEITERQGGDFEGMKIHIDKYknhgVRFAIDDFGTGYSNLNLVAALDVDEI 198
Cdd:PRK11596 107 DGPTLIALRQQPAILRLIER--LPW--LRFELVEHIRLPKDSPFASMCEF----GPLWLDDFGTGMANFSALSEVRYDYI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 199 KIDKSL-----TSAIGTeslryDLLPGLHEMFRSIADKIVFEGVETQEQvnylktfW------PQSYAQGWYYSRALPLE 267
Cdd:PRK11596 179 KVARELfimlrQSEEGR-----NLFSQLLHLMNRYCRGVIVEGVETPEE-------WrdvqrsPAFAAQGYFLSRPAPFE 246


                 ....*...
gi 694095094 268 EARKLTIR 275
Cdd:PRK11596 247 TLETLPLA 254
YuxH COG3434
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction ...
 46-273 2.07e-03

c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction mechanisms];


Pssm-ID: 442660 [Multi-domain]  Cd Length: 407  Bit Score: 39.02  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094  46 QPIYRiEDGQICGFEALLRwkdERLGNINPEVfiplserEGLQEDVTlfVINHAIREF-IHTAIQNEIFLsVNINPSDLD 124
Cdd:COG3434    9 QPILD-RDQRVVGYELLFR---SGLENSAPDV-------DGDQATAR--VLLNAFLEIgLDRLLGGKLAF-INFTEELLL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694095094 125 SEKFRDkllgliseynIPYKTILLEITERQGGDFEGMKIhIDKYKNHGVRFAIDDFGTGYSNLNLVAALDVdeIKIDksl 204
Cdd:COG3434   75 SDLPEL----------LPPERVVLEILEDVEPDEELLEA-LKELKEKGYRIALDDFVLDPEWDPLLPLADI--IKID--- 138

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 694095094 205 TSAIGTESLRyDLLPGLHEmfRSIadKIVFEGVETQEQVNYLKT--FwpqSYAQGWYYSRALPLeEARKLT 273
Cdd:COG3434  139 VLALDLEELA-ELVARLKR--YGI--KLLAEKVETREEFELCKElgF---DLFQGYFFSKPEIL-KGKKLP 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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