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Conserved domains on  [gi|692337410|gb|AIS11327|]
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RNA methyltransferase [Pseudomonas chlororaphis subsp. aurantiaca]

Protein Classification

RNA methyltransferase( domain architecture ID 11426243)

RNA methyltransferase such as Pseudomonas aeruginosa TrmJ, which is a tRNA:Cm32/Um32/Am32 methyltransferase involved in translational fidelity and the oxidative stress response

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 2-248 9.36e-134

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 376.76  E-value: 9.36e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   2 LQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA 81
Cdd:COG0565    1 LDNIRVVLVEPQHPGNIGAAARAMKNFGLSDLRLVNPRGWPDEEARAMASGADDVLENARVVDTLEEALADCDLVVGTTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  82 RDRRIPWPLLDPRESGVKVVQEAgQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMSW 161
Cdd:COG0565   81 RPRELRKPVLTPREAAEELLARA-AGGKVALVFGRERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 162 LAAEGQPSKVEkdevasprsDELATMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGILT 241
Cdd:COG0565  160 LEAPPLPPPPE---------PEPATAEELEGLYEHLEELLDAIGFLDPEKPEKLMRRLRRLFGRARLTEREVRTLRGILR 230


                 ....*..
gi 692337410 242 ETQKAAR 248
Cdd:COG0565  231 ALERRLK 237
 
Name Accession Description Interval E-value
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 2-248 9.36e-134

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 376.76  E-value: 9.36e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   2 LQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA 81
Cdd:COG0565    1 LDNIRVVLVEPQHPGNIGAAARAMKNFGLSDLRLVNPRGWPDEEARAMASGADDVLENARVVDTLEEALADCDLVVGTTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  82 RDRRIPWPLLDPRESGVKVVQEAgQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMSW 161
Cdd:COG0565   81 RPRELRKPVLTPREAAEELLARA-AGGKVALVFGRERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 162 LAAEGQPSKVEkdevasprsDELATMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGILT 241
Cdd:COG0565  160 LEAPPLPPPPE---------PEPATAEELEGLYEHLEELLDAIGFLDPEKPEKLMRRLRRLFGRARLTEREVRTLRGILR 230


                 ....*..
gi 692337410 242 ETQKAAR 248
Cdd:COG0565  231 ALERRLK 237
PRK15114 PRK15114
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional
 1-250 3.35e-110

tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional


Pssm-ID: 185069  Cd Length: 245  Bit Score: 317.47  E-value: 3.35e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   1 MLQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTS 80
Cdd:PRK15114   1 MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNATIVDTLDEALAGCSLVVGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  81 ARDRRIPWPLLDPRESGVKVVQEAGQgAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMS 160
Cdd:PRK15114  81 ARSRTLPWPMLDPRECGLKSVAEAAN-APVALVFGRERVGLTNDELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 161 WLAA-EGQPSKVEKDEVASPrsdelaTMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGI 239
Cdd:PRK15114 160 WLATqENGEPQVEHEETPYP------LVDDLERFYGHLEQTLLATGFIRENHPGQVMNKLRRLFTRARPESQELNILRGI 233

                        250
                 ....*....|.
gi 692337410 240 LTETQKAARGE 250
Cdd:PRK15114 234 LASIEQQNKGN 244
rRNA_methyl_1 TIGR00050
RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of ...
 2-245 6.09e-89

RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases, and is now characterized, in E. coli, as a tRNA:Cm32/Um32 methyltransferase. It may be named TrMet(Xm32), or TrmJ, according to the nomenclature style chosen [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272876 [Multi-domain]  Cd Length: 233  Bit Score: 263.11  E-value: 6.09e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410    2 LQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA 81
Cdd:TIGR00050   1 LENIRIVLVEPSHPGNIGSIARAMKNMGLTELRLVNPRVKLEEEAYALAAGARDILDNAKVVDTLDEALDDCDFVVGTSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   82 RDRRIPWPLLDPRESGVKVVQEAGQgaeIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMSW 161
Cdd:TIGR00050  81 RSRNLQRPMLTPRELAPKLVAEKGK---VALVFGREDSGLTNEELQKCHVLVSIPTSEEYPSLNLSHAVAVILYELRMAW 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  162 LAAegQPSKVEKdevasprsdELATMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGILT 241
Cdd:TIGR00050 158 LAQ--QENLSEM---------PYATVDDLELLLEHLEETLLSLGFIPEHKPRQVMRKFRRLYGRAGLEKRELHILRGILR 226


                  ....
gi 692337410  242 ETQK 245
Cdd:TIGR00050 227 SIEK 230
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 5-156 1.47e-75

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 226.22  E-value: 1.47e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHE-ADARASGATDILENAQVVATLEDALAGCTLVFGTSARD 83
Cdd:cd18093    1 IRVVLVEPQHPGNIGAVARAMKNFGLSDLRLVNPRCDDPEEaARALASGAEDVLENAKVYDTLEEALADCDLVVATTARP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692337410  84 RRIPWPLLDPRESgVKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYE 156
Cdd:cd18093   81 RGLRRPLLTPREL-AELLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTIPTNPEYPSLNLAQAVAIVLYE 152
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 4-155 9.16e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 129.57  E-value: 9.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410    4 NIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADAR--ASGATDILENAqVVATLEDALAGCTL----VF 77
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPKAIraSAGALFHLPLV-VVDNLEEALKDLKEagyaVV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 692337410   78 GTSARDRRIPWPLLDPResgvkvvqeagqgaeIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAY 155
Cdd:pfam00588  80 ATSLGGKSLYEIDFPKK---------------VALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
tRNAmeth_TrmJ_Sulfolob NF041077
tRNA (cytidine-2'-O-)-methyltransferase TrmJ;
5-225 4.77e-26

tRNA (cytidine-2'-O-)-methyltransferase TrmJ;


Pssm-ID: 469004  Cd Length: 229  Bit Score: 101.64  E-value: 4.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIfPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA--- 81
Cdd:NF041077   2 IRVVLVEPEGEYNVGFIARLCKNFEVDELYIVNPKC-DLNEALKFSAKGSEILEKAKIVNNFDDAIKDLDLKIATSSiad 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  82 ------RDRRIPWPLLDpresgvkvvqeAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAY 155
Cdd:NF041077  81 nkgdmlRKSIKPWEISD-----------LIGGKKVALIFGRESVGLTREEISKADFLLHIPANPEYPVLNLSHAVGIVLY 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 156 EVrmsWlaaegqPSKVEKDEVASPRSDELATMDE-LERFYEHL------EQTLVAID------FLDPEKPRHLMARLRRL 222
Cdd:NF041077 150 EI---W------KSRGNKSTKYNVSSESLKLIDKyVKTLYDLIkrsegdESMYIALKralikgIRDEEEARAVVRFLRKL 220


                 ...
gi 692337410 223 YGR 225
Cdd:NF041077 221 YMR 223
 
Name Accession Description Interval E-value
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 2-248 9.36e-134

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 376.76  E-value: 9.36e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   2 LQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA 81
Cdd:COG0565    1 LDNIRVVLVEPQHPGNIGAAARAMKNFGLSDLRLVNPRGWPDEEARAMASGADDVLENARVVDTLEEALADCDLVVGTTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  82 RDRRIPWPLLDPRESGVKVVQEAgQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMSW 161
Cdd:COG0565   81 RPRELRKPVLTPREAAEELLARA-AGGKVALVFGRERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 162 LAAEGQPSKVEkdevasprsDELATMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGILT 241
Cdd:COG0565  160 LEAPPLPPPPE---------PEPATAEELEGLYEHLEELLDAIGFLDPEKPEKLMRRLRRLFGRARLTEREVRTLRGILR 230


                 ....*..
gi 692337410 242 ETQKAAR 248
Cdd:COG0565  231 ALERRLK 237
PRK15114 PRK15114
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional
 1-250 3.35e-110

tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional


Pssm-ID: 185069  Cd Length: 245  Bit Score: 317.47  E-value: 3.35e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   1 MLQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTS 80
Cdd:PRK15114   1 MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNATIVDTLDEALAGCSLVVGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  81 ARDRRIPWPLLDPRESGVKVVQEAGQgAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMS 160
Cdd:PRK15114  81 ARSRTLPWPMLDPRECGLKSVAEAAN-APVALVFGRERVGLTNDELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 161 WLAA-EGQPSKVEKDEVASPrsdelaTMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGI 239
Cdd:PRK15114 160 WLATqENGEPQVEHEETPYP------LVDDLERFYGHLEQTLLATGFIRENHPGQVMNKLRRLFTRARPESQELNILRGI 233

                        250
                 ....*....|.
gi 692337410 240 LTETQKAARGE 250
Cdd:PRK15114 234 LASIEQQNKGN 244
rRNA_methyl_1 TIGR00050
RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of ...
 2-245 6.09e-89

RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases, and is now characterized, in E. coli, as a tRNA:Cm32/Um32 methyltransferase. It may be named TrMet(Xm32), or TrmJ, according to the nomenclature style chosen [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272876 [Multi-domain]  Cd Length: 233  Bit Score: 263.11  E-value: 6.09e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410    2 LQNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA 81
Cdd:TIGR00050   1 LENIRIVLVEPSHPGNIGSIARAMKNMGLTELRLVNPRVKLEEEAYALAAGARDILDNAKVVDTLDEALDDCDFVVGTSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   82 RDRRIPWPLLDPRESGVKVVQEAGQgaeIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRMSW 161
Cdd:TIGR00050  81 RSRNLQRPMLTPRELAPKLVAEKGK---VALVFGREDSGLTNEELQKCHVLVSIPTSEEYPSLNLSHAVAVILYELRMAW 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  162 LAAegQPSKVEKdevasprsdELATMDELERFYEHLEQTLVAIDFLDPEKPRHLMARLRRLYGRSSVSRAEMNILRGILT 241
Cdd:TIGR00050 158 LAQ--QENLSEM---------PYATVDDLELLLEHLEETLLSLGFIPEHKPRQVMRKFRRLYGRAGLEKRELHILRGILR 226


                  ....
gi 692337410  242 ETQK 245
Cdd:TIGR00050 227 SIEK 230
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 5-156 1.47e-75

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 226.22  E-value: 1.47e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHE-ADARASGATDILENAQVVATLEDALAGCTLVFGTSARD 83
Cdd:cd18093    1 IRVVLVEPQHPGNIGAVARAMKNFGLSDLRLVNPRCDDPEEaARALASGAEDVLENAKVYDTLEEALADCDLVVATTARP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692337410  84 RRIPWPLLDPRESgVKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYE 156
Cdd:cd18093   81 RGLRRPLLTPREL-AELLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTIPTNPEYPSLNLAQAVAIVLYE 152
PRK10433 PRK10433
putative RNA methyltransferase; Provisional
 5-225 2.66e-39

putative RNA methyltransferase; Provisional


Pssm-ID: 236693  Cd Length: 228  Bit Score: 136.27  E-value: 2.66e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSARDR 84
Cdd:PRK10433   3 LTIILVAPARAENVGAAARAMKTMGFSELRIVDSQAHLEPAARWVAHGSGDILDNAKVFDTLAEALHDVDFTVATTARSR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  85 RIPWPLLDPRESgVKVVQEAGQG-AEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEvrmswLA 163
Cdd:PRK10433  83 AKFHYYATPAEL-VPLLEEKSSWmSHAALVFGREDSGLTNEELALADVLTGVPMAADYPSLNLGQAVMVYCYQ-----LA 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 692337410 164 AEGQPSKVeKDEVASPRSdelatmdeLERFYEHLEQTLVAIDFLDPEKPRH-LMARLRRLYGR 225
Cdd:PRK10433 157 GLMQQPAK-SDTTADEGQ--------LQALRQRAMRLLTTLGVADDEKLVDwLQQRLGLLEQR 210
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 4-155 9.16e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 129.57  E-value: 9.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410    4 NIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADAR--ASGATDILENAqVVATLEDALAGCTL----VF 77
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPKAIraSAGALFHLPLV-VVDNLEEALKDLKEagyaVV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 692337410   78 GTSARDRRIPWPLLDPResgvkvvqeagqgaeIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAY 155
Cdd:pfam00588  80 ATSLGGKSLYEIDFPKK---------------VALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 6-156 3.62e-27

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 102.30  E-value: 3.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   6 RVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARASGATDILENAQVVATLEDALA-----GCTLvFGTS 80
Cdd:cd18082    1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKslkeeGYPL-IGLE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 692337410  81 ARDRRIPWPLLDPRESGvkvvqeagqgaEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYE 156
Cdd:cd18082   80 LTDGSIPLSEFKFKKPK-----------KIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALYE 144
tRNAmeth_TrmJ_Sulfolob NF041077
tRNA (cytidine-2'-O-)-methyltransferase TrmJ;
5-225 4.77e-26

tRNA (cytidine-2'-O-)-methyltransferase TrmJ;


Pssm-ID: 469004  Cd Length: 229  Bit Score: 101.64  E-value: 4.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIfPSHEADARASGATDILENAQVVATLEDALAGCTLVFGTSA--- 81
Cdd:NF041077   2 IRVVLVEPEGEYNVGFIARLCKNFEVDELYIVNPKC-DLNEALKFSAKGSEILEKAKIVNNFDDAIKDLDLKIATSSiad 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  82 ------RDRRIPWPLLDpresgvkvvqeAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAY 155
Cdd:NF041077  81 nkgdmlRKSIKPWEISD-----------LIGGKKVALIFGRESVGLTREEISKADFLLHIPANPEYPVLNLSHAVGIVLY 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410 156 EVrmsWlaaegqPSKVEKDEVASPRSDELATMDE-LERFYEHL------EQTLVAID------FLDPEKPRHLMARLRRL 222
Cdd:NF041077 150 EI---W------KSRGNKSTKYNVSSESLKLIDKyVKTLYDLIkrsegdESMYIALKralikgIRDEEEARAVVRFLRKL 220


                 ...
gi 692337410 223 YGR 225
Cdd:NF041077 221 YMR 223
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 6-157 7.24e-11

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 58.62  E-value: 7.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   6 RVVLVNTSHPGNIGGAARAMKNMGlSRLVLVEPRIFPSHEADARASGAtDILENAQVV--ATLEDALAGCT--LVFGTSA 81
Cdd:cd18094    1 NIVLYEPEIPQNTGNIARTCAATG-ARLHLIEPLGFSLDDKRLKRAGL-DYWDHVDLTvhDSWEAFLEALPpgRLFLFTT 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 692337410  82 RDRRIPWplldpresgvkvvqEAGQGAEIALVFGREDSGLTNDELQRC-HFHVHIPSDPEFSSLNLATAVQVLAYEV 157
Cdd:cd18094   79 KGTKPYT--------------DFDFKPGDYLVFGRESTGLPEEILDAFpDRRLRIPMRPKVRSLNLSNSVAIVLYEA 141
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 7-156 1.02e-10

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 58.21  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARAS-GA---TDILENAQVVATLEDALAGCTLVFGTSAR 82
Cdd:cd18095    3 LVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASmGAlfrLPIIRVDDLEELLEELKEAGYKVVAADLD 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692337410  83 DRRIPWPLLDPREsgvkvvqeagqgaeIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYE 156
Cdd:cd18095   83 GGSSLYDLDLPKP--------------VALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYE 142
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 7-159 3.44e-09

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 54.12  E-value: 3.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARAS-GATDILEnaQVVATLEDALAgcTLvfgtsaRDRR 85
Cdd:cd18104    3 LVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASlGAVFTLP--VAEASSEETLA--WL------KENK 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692337410  86 IPWPLLDPRESgvKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVRM 159
Cdd:cd18104   73 IRILATTPKAE--KLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALR 144
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 7-158 6.22e-09

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 55.20  E-value: 6.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARAS-GAtdiLENAQV--VATLEDAL-----AGCTlVFG 78
Cdd:COG0566  118 LVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASaGA---LFHVPVarVTNLADALeelkeAGFW-VVG 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  79 TSARDRripwplldpresgvKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEVR 158
Cdd:COG0566  194 TDLDGE--------------ASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLYEAA 259
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 94-157 8.31e-09

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 52.77  E-value: 8.31e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692337410  94 RESGVKVVQEAGQGAE----------IALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEV 157
Cdd:cd18103   70 KEAGFWIYGADGEAEKslydvdltgpLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGIILYEI 143
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 5-157 1.08e-08

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 52.73  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   5 IRVVLVNTSHPGNIGGAARAMKNMGlSRLVLVEPRIFPSHEADARASGaTDILENAQVV-----ATLEDALAGCTLVFGT 79
Cdd:COG0219    2 LHIVLYEPEIPQNTGNIIRLCAATG-ARLHLIEPLGFSLDDKKLKRAG-LDYWELVDLTvhdswEAFLEALPGGRLFLFT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692337410  80 SARDRRIPwplldpresgvkvvqEAGQGAEIALVFGREDSGLTNDELQR-CHFHVHIPSDPEFSSLNLATAVQVLAYEV 157
Cdd:COG0219   80 TKGTKPYT---------------DVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEA 143
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 9-155 1.78e-08

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 51.88  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   9 LVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIfpsheadARASGATDilenaqvvatledalagctlvfgTSARDRRIPW 88
Cdd:cd18098    5 IENPKTPKNVGTLWRAAGCLGASFVFTIGARY-------KRRKQSTD-----------------------TSKAWRHIPL 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  89 -------PLLDPRESGVKVVQ-EAGQGAE----------IALVFGREDSGLTNDELQRCHFHVHIPSDpefSSLNLATAV 150
Cdd:cd18098   55 fhyddleDLAEPLPFGAVLVAvELTEGATplpdfkhpdrAVYLLGPEDGGLPQEVLARCHHVVYLPTR---GSLNVAVAG 131


                 ....*
gi 692337410 151 QVLAY 155
Cdd:cd18098  132 SIVLY 136
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 7-157 3.22e-08

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 51.41  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFPSHEADARAS-GATDILENAQVVATLEdALAGCtlvfgtSARDRR 85
Cdd:cd18097    3 VVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTAlGAEESVPWEHFEDTLE-AVRAL------KARGYT 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 692337410  86 IpWPLldPRESGVKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEV 157
Cdd:cd18097   76 I-IAL--ETTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYEL 144
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 106-156 3.14e-06

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 45.71  E-value: 3.14e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 692337410 106 QGAEIALVFGREDSGLTNDELQRCH----FHVHIPSDPEFSSLNLATAVQVLAYE 156
Cdd:cd18106   93 CSGPIVLVIGGETHGVSPEAYKLAHstggSRVHIPLANGVDSLNSAVAASILLFE 147
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 7-149 5.86e-05

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 41.82  E-value: 5.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPRIFpsheaDARASGATDILENAQVVATLEDALAGCTlvfgtsardrri 86
Cdd:cd18096    3 LVLHNVAKRHNIGTIVRSANAFGVKEVHLVGRRKF-----NPFGAMGTDRHVKFRHFDTLAEAKEYLK------------ 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 692337410  87 pwplldprESGVKVVQ-EAGQGAEI----------ALVFGREDSGLTNDELQRCHFHVHIPS-DPEFSSLNLATA 149
Cdd:cd18096   66 --------ERGIRLVGvEIVPGAEPiethpfpgdtAFVLGNEGTGLSDEQLAICDGFVYIPQyGSGTASLNVSVA 132
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 3-159 1.50e-04

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 41.30  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   3 QNIRVVLVNTSHPGNIGGAARAMKNMGLSRLVLVEPR--IFPSHEADARASGATDIlenaQVVATLEDALA-----GCTL 75
Cdd:cd18092   15 RDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKnkFKKNRGVAMGADKWLDV----HRHDSTEECLAalkeqGYRI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410  76 VfGTSARDRRIPWPLLDPRESgvkvvqeagqgaeIALVFGREDSGLTNDELQRCHFHVHIP----SDpefsSLNLATAVQ 151
Cdd:cd18092   91 V-ATSLSPDAVPLDELDYTRP-------------TALVFGNEKDGVSEEALAAADERVYIPmygfVE----SLNVSVAAA 152


                 ....*...
gi 692337410 152 VLAYEVRM 159
Cdd:cd18092  153 IILYELQR 160
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 101-156 3.76e-04

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 39.83  E-value: 3.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 692337410 101 VQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFS-SLNLATAVQVLAYE 156
Cdd:cd18109   84 LYEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGKGAeSLNVAVATAILLSE 140
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 7-157 2.20e-03

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 37.75  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692337410   7 VVLVNTSHPGNIGGAARAMKNMGLSRLVlvepriFPSHEADA------RASGATDILENAQVVATLEDALAgctlvFGTS 80
Cdd:cd18107    3 VLFDRPTSPGNLGTIIRSADALGAHGLV------VTGHAADVydpktiRASTGSLFSLPIVRVPSNRELED-----WVEA 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 692337410  81 ARDRRIPWPLLDPRESGVKVVQEAGQGAEIALVFGREDSGLTNDELQRCHFHVHIPSDPEFSSLNLATAVQVLAYEV 157
Cdd:cd18107   72 RKARGTPLQLVGTDEHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYEA 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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