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Conserved domains on  [gi|69219029|gb|AAZ04151|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Fruhstorferiola omei]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 2.72e-88

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 268.23  E-value: 2.72e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    1 MTNNSKKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   81 KYPMgweMEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSKFMFVIIISSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNKPSLILS 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330
                 ....*....|....*....
gi 69219029  321 MTVMISTMGLMSTSMLVYL 339
Cdd:MTH00160 317 FLSFISLFGLILSSLLFLL 335
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 2.72e-88

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 268.23  E-value: 2.72e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    1 MTNNSKKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   81 KYPMgweMEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSKFMFVIIISSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNKPSLILS 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330
                 ....*....|....*....
gi 69219029  321 MTVMISTMGLMSTSMLVYL 339
Cdd:MTH00160 317 FLSFISLFGLILSSLLFLL 335
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-270 4.37e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.13  E-value: 4.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    24 SNSWFGVWMGLEINLLSFIPMLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYPMGWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    89 EFIPSMVVSSSLLLKIGAAPFHFWFPEV-MGTSTWINCLMLMTWQKIAPMMVL-------SYCIQLSKFMFVIIISSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAyEGAPTPVSALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEM----YFIVYSLLSMIMVLLF-----KQMNLFFLNQIYSSTN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQaaifHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 69219029   232 MKTEIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENN 270
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-330 3.82e-12

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 66.90  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029     8 LLFLSTLmmGTILSISSNSWFGVWMGLEI-NLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:TIGR01770 107 LLLFALL--GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    79 --QMKYPMGWEMEFIPSMV-----VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIA---PMMVLSYCIQ--- 145
Cdd:TIGR01770 185 feDLLLFLSNGMLNISLLLlgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   146 ---LSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMVS--ENIWEM--YFIVYSLLSMIMVLLFKQM 218
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGtlEGIKAVlfYIFIYALMSLGAFGVLSLL 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   219 NLFFLNQIYSSTNMKTEIK------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRI 292
Cdd:TIGR01770 345 RSYKDEWIEYISDFAGLFKtnpilaILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 69219029   293 sfSALILSYSENSWSMINAFNKPSlilSMTVMISTMGL 330
Cdd:TIGR01770 425 --VKVMYFDKPERRIPSNPQSKAQ---SLLLSISALFI 457
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-292 1.11e-09

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 59.36  E-value: 1.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:COG1007 107 LLLFATL--GMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgsln 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  79 ------QMKYPMGWEMEFIPSMV-VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:COG1007 185 lagiaaALAAGGANSPLLLLGLVlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGL 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029 143 CIQLSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMV-SENIWE---MYFIVYSLlsmimvllfkqM 218
Cdd:COG1007 265 AADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029 219 NL---FFLNQIYSSTNMKTEIK-------------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLT 282
Cdd:COG1007 334 NLgafAVILLLSRKGGEAEEIEdlaglarrspllaLAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                       330
                ....*....|
gi 69219029 283 MITLYYYMRI 292
Cdd:COG1007 414 VISAYYYLRV 423
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 2.72e-88

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 268.23  E-value: 2.72e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    1 MTNNSKKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   81 KYPMgweMEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSKFMFVIIISSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNKPSLILS 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330
                 ....*....|....*....
gi 69219029  321 MTVMISTMGLMSTSMLVYL 339
Cdd:MTH00160 317 FLSFISLFGLILSSLLFLL 335
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 8-340 2.48e-50

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 170.88  E-value: 2.48e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    8 LLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYP---M 84
Cdd:MTH00041   7 IFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGswsI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   85 GWEMEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQL--SKFMFVIIISSIIIGA 162
Cdd:MTH00041  87 NGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLlnSNILILCGILSVLVGG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  163 LGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFL 242
Cdd:MTH00041 167 WGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFLFIL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  243 SLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMIN-----AFNKPSL 317
Cdd:MTH00041 247 SILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSwrnsgNITVYGV 326

                        330       340
                 ....*....|....*....|...
gi 69219029  318 ILSMTVMISTMGLMSTSMLVYLY 340
Cdd:MTH00041 327 ILSILSSISILGLLLIPLFLSFL 349
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 8-340 3.40e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 165.40  E-value: 3.40e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    8 LLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSIlLIQMKYPMGWE 87
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAI-IINLMYSGQWT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   88 MEFIP----SMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsYCIQLS---KFMFVIIISSIII 160
Cdd:MTH00105  86 ITKLTnptaSTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIL-YQISPSinpNLLLTLAILSILI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00105 165 GGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLI 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFS-ALILSYSENSWSMINAFN--KPSL 317
Cdd:MTH00105 245 LLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYStSLTMFPSTNNMKMKWQFEntKPMT 324

                        330       340
                 ....*....|....*....|...
gi 69219029  318 ILSMTVMISTMGLMSTSMLVYLY 340
Cdd:MTH00105 325 LLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 7-336 3.28e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 162.68  E-value: 3.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    7 KLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILlIQMKYPMGW 86
Cdd:MTH00112   6 KLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSST-TNAWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   87 EM----EFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQL--SKFMFVIIISSIII 160
Cdd:MTH00112  85 DItqltNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSlnPTLLLTLAILSTLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00112 165 GGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISF-SALILSYSENSWSMINAFNKP-SLI 318
Cdd:MTH00112 245 MLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYiSTITLPPNTTNMMMKWRTKPKkNTL 324

                        330
                 ....*....|....*...
gi 69219029  319 LSMTVMISTMGLMSTSML 336
Cdd:MTH00112 325 TATLTTLSTLLLPLSPMI 342
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 10-340 7.61e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 161.63  E-value: 7.61e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   10 FLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILL----------IQ 79
Cdd:MTH00070   9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTInawftgewtiMN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   80 MKYPMgwemefiPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsycIQLSK-----FMFVII 154
Cdd:MTH00070  89 MQTPL-------PTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALL---IQISHllnsnLLIIMG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  155 ISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKT 234
Cdd:MTH00070 159 LLSTLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  235 EIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFsALILSYS---ENSWSMINA 311
Cdd:MTH00070 239 TLTSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSY-AMSLTTSpntSNSKLYWRF 317

                        330       340
                 ....*....|....*....|....*....
gi 69219029  312 FNKPSLILSMTVMISTMGLMSTSMLVYLY 340
Cdd:MTH00070 318 KNKTNNLLSLTIILSLMLLPITPTILNLF 346
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-328 5.80e-45

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 156.37  E-value: 5.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    9 LFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMgwem 88
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYL---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   89 EFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSKFMFVIIISSIIIGALGGLNQ 168
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  169 TSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFLSLLSLG 248
Cdd:MTH00197 158 SNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  249 GLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNKPSLILSMTVMISTM 328
Cdd:MTH00197 238 GLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMMLPLL 317
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 8-339 2.29e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 152.82  E-value: 2.29e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    8 LLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMGWE 87
Cdd:MTH00200   7 PLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   88 MEFIPSMV---VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLS--YCIQLSKFMFVIIISSIIIGA 162
Cdd:MTH00200  87 SEMLGPLSetlILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLSVLVGG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  163 LGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFL 242
Cdd:MTH00200 167 WGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLGL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  243 SLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNK--PSLILS 320
Cdd:MTH00200 247 TLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKsnSNLLVG 326

                        330
                 ....*....|....*....
gi 69219029  321 MTVMISTMGLMSTSMLVYL 339
Cdd:MTH00200 327 LLLLLSILGLPLTPQLLFL 345
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 7-321 2.04e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 149.65  E-value: 2.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    7 KLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMGW 86
Cdd:MTH00144   6 NLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   87 EMEFIPsmvvsSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCI---QLSKFMFVIIISSIIIGAL 163
Cdd:MTH00144  86 SMSLLL-----LGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  164 GGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFlS 243
Cdd:MTH00144 161 GGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIIS-L 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 69219029  244 LLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILSYSENSWSMINAFNKPSLILSM 321
Cdd:MTH00144 240 LLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNL 317
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 8-300 1.03e-39

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 142.61  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    8 LLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMgwe 87
Cdd:MTH00011   9 FLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSL--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   88 MEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYC--IQLSKFMFVIIISSIIIGALGG 165
Cdd:MTH00011  86 LKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFtsHNILPMMTSMAAMSALAGGLGG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  166 LNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFLSLL 245
Cdd:MTH00011 166 MNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLL 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 69219029  246 SLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFSALILS 300
Cdd:MTH00011 246 SLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLS 300
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 9-336 4.13e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 138.78  E-value: 4.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    9 LFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSIL----------LI 78
Cdd:MTH00135   8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTtnawltgqwdIQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   79 QMKYPmgwemefIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsycIQL----SKFMFVII 154
Cdd:MTH00135  88 QMSHP-------LPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALI---LQIaptnPTLLITLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  155 ISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLNQIYSSTNMKT 234
Cdd:MTH00135 158 LTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  235 EIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRISFsALILSYSENSWSMINAFNK 314
Cdd:MTH00135 238 ALTALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSY-AMTLTISPNTLNGTTPWRL 316

                        330       340
                 ....*....|....*....|..
gi 69219029  315 PSLILSMTVMISTMglMSTSML 336
Cdd:MTH00135 317 PSTQLTLPLAISTT--ATLMLL 336
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-270 4.37e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.13  E-value: 4.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    24 SNSWFGVWMGLEINLLSFIPMLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYPMGWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    89 EFIPSMVVSSSLLLKIGAAPFHFWFPEV-MGTSTWINCLMLMTWQKIAPMMVL-------SYCIQLSKFMFVIIISSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAyEGAPTPVSALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   161 GALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEM----YFIVYSLLSMIMVLLF-----KQMNLFFLNQIYSSTN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQaaifHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 69219029   232 MKTEIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENN 270
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-292 3.94e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 81.23  E-value: 3.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   16 MGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMN-ESSIKYFIVQAMASTMLLFSI----------------LLI 78
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSaEAGLKYFVLGALSSGLFLFGCallcgttgglhlsyinLVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   79 QMKYPMGWEMEFIPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSKFMFVIIISSI 158
Cdd:MTH00196  84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  159 IIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMV----SENIWEMYFIVYSLLSM--IMVLLFKQMNLFFLNQIYSSTNM 232
Cdd:MTH00196 164 FVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIgsfeSIQASLVYLFIYIIMSIcvFSIILALNVYKNLIIEFSGLSRR 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  233 KTEIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRI 292
Cdd:MTH00196 244 LPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 16-292 7.81e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 71.97  E-value: 7.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   16 MGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMN-ESSIKYFIVQAMASTMLLFSILLIqmkYPMGWEMEF---- 90
Cdd:MTH00199 108 LGSLLLVSSINWLSIYLAIELQTLTLFILVALKRDSAYStEAGLKYFVLGAVSSGLFLFGCALL---YGLTGETSIqgin 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   91 ------IPSMVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSKFMFVIIISSIIIGALG 164
Cdd:MTH00199 185 siltgdVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  165 GLNQTSLRQLLAYSSTSHLGWMISSLMVSEN----IWEMYFIVYSLLSMIMVLLFKQMNLF--FLNQIYSSTNMKTEIKF 238
Cdd:MTH00199 265 ALNQTKIKRLLAYSGIGHMGFILFGVAIGSFesiqASLIYMIIYVIMSICSFSIILSLKLTkgLIVEVSGLSRKNPVIAL 344

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 69219029  239 MMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRI 292
Cdd:MTH00199 345 TLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-330 3.82e-12

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 66.90  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029     8 LLFLSTLmmGTILSISSNSWFGVWMGLEI-NLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:TIGR01770 107 LLLFALL--GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    79 --QMKYPMGWEMEFIPSMV-----VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIA---PMMVLSYCIQ--- 145
Cdd:TIGR01770 185 feDLLLFLSNGMLNISLLLlgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   146 ---LSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMVS--ENIWEM--YFIVYSLLSMIMVLLFKQM 218
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGtlEGIKAVlfYIFIYALMSLGAFGVLSLL 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   219 NLFFLNQIYSSTNMKTEIK------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRI 292
Cdd:TIGR01770 345 RSYKDEWIEYISDFAGLFKtnpilaILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 69219029   293 sfSALILSYSENSWSMINAFNKPSlilSMTVMISTMGL 330
Cdd:TIGR01770 425 --VKVMYFDKPERRIPSNPQSKAQ---SLLLSISALFI 457
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
8-292 3.02e-11

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 64.07  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029    8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:PRK05777 108 LVLFALL--GMMVMVSANDLLTLFLGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgsls 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   79 ------QMKYPMGWEMEFIPSMV-VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:PRK05777 186 fagiakALADGSGNSLLLLFGLVfLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafgGL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  143 CIQLSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFF 222
Cdd:PRK05777 266 SEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMTLGAFGVISLL 345

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 69219029  223 LNQIYSSTNMKT---------EIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLTMITLYYYMRI 292
Cdd:PRK05777 346 RRKGGEAESISDfaglskrspLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRV 424
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-292 1.11e-09

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 59.36  E-value: 1.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLA-NNKNMMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:COG1007 107 LLLFATL--GMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgsln 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  79 ------QMKYPMGWEMEFIPSMV-VSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:COG1007 185 lagiaaALAAGGANSPLLLLGLVlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGL 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029 143 CIQLSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLMV-SENIWE---MYFIVYSLlsmimvllfkqM 218
Cdd:COG1007 265 AADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029 219 NL---FFLNQIYSSTNMKTEIK-------------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTIMVMLT 282
Cdd:COG1007 334 NLgafAVILLLSRKGGEAEEIEdlaglarrspllaLAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                       330
                ....*....|
gi 69219029 283 MITLYYYMRI 292
Cdd:COG1007 414 VISAYYYLRV 423
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 16-187 1.60e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 56.02  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   16 MGTILSISSNSWFGVWMGLEINLLSFIPM---------LANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMGW 86
Cdd:MTH00198 199 LGGLLLIESANWLTIYLALEFQTLALFILagegsqpgsHFPSPGNTPPESGLKYWILGAMSSGFYLFGCALYFGFTGNEG 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   87 EMEFIPS-----------------MVVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSKF 149
Cdd:MTH00198 279 MLGTILSatlettnielrqgslgyLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKL 358

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 69219029  150 MFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMI 187
Cdd:MTH00198 359 LLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-187 1.78e-05

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 46.29  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  10 FLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNESSIKYFIVQAMASTMLLFSILLIQMKY------P 83
Cdd:COG0651 112 LFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATgtlnmaD 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  84 MGWEMEFIPSMVVSSSLLL-------KIGAAPFHFWFPEVMGT-STWINCLM--LMTwqKIAPMMVL---------SYCI 144
Cdd:COG0651 192 LAARLAELDPGLLLAAFALllvgfgiKAALFPLHFWLPDAYPAaPSPVSALLsgLLT--KVGVYAILrvltllfgaDPAL 269

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 69219029 145 QLSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMI 187
Cdd:COG0651 270 FLGTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYIL 312
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 55-193 7.27e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 41.24  E-value: 7.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   55 ESSIKYFIVQAMASTMLLFSILLIQMKY---PMGW---EMEFIPSMV-------VSSSLLLKIGAAPFHFWFPEVMGTS- 120
Cdd:PRK08376 172 EAGIKYMFVGSLASSMVLLGIALLYGQYgtlNMAYlavKMSENPTVVakialalFIAGLAMKSGAVPVHMWLPDAYPAAp 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  121 TWINCLMLMTWQ-KIAPMMVLSYCI--------QLSKFMFVIIISSIIIGALGGLNQTSLRQLLAYSSTSHLGWMISSLM 191
Cdd:PRK08376 252 SSISAMLLVIKQaGLYALARVLFSIygpainlaTVGWVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMLLGLG 331


                 ..
gi 69219029  192 VS 193
Cdd:PRK08376 332 VG 333
PRK12650 PRK12650
DUF4040 family protein;
108-192 2.74e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 39.64  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029  108 PFHFWFPEVMGTSTWINCLMLmtwqkiAPMMVLSYCIQLSKF-------------MFVIIISSIIIGALGGLNQTSLRQL 174
Cdd:PRK12650 226 PFHFWLPEAMAAITPVSAFLH------AAAVVKAGIYLLLRFspvfhdvavwnwlLIIVGMITALMGAVFAVQKTDLKKL 299

                         90
                 ....*....|....*...
gi 69219029  175 LAYSSTSHLGWMISSLMV 192
Cdd:PRK12650 300 TAYSTVSQLGWIVATIGV 317
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 14-224 4.26e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 38.31  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   14 LMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNMMMNessikYFIVQAMASTMLLFSILLIQMkypmgwemefips 93
Cdd:MTH00091   3 LSLLNFMSLNIFVWWSVFLLMTLLFVFLNKGMGSYSSLFNY-----FVLQESLGLLFLLFSFGYFQF------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219029   94 mvvsSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIqlSKFMFVIIISSIIIGALGGLNQTSLRQ 173
Cdd:MTH00091  65 ----LILMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFF--SKNFFFLLLFGLLICFFQMFLLKSYKN 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 69219029  174 LLAYSSTSHLGWMISSLMVSENIWEMYFIVYSLLSMIMVLLFKQMNLFFLN 224
Cdd:MTH00091 139 LLILSSTESFNWLILSFFFSFFNVFFLFFYYFLLMLFLIPKFNNVNKLNFV 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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