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Conserved domains on  [gi|69122971|ref|NP_001012745|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-221 6.48e-29

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 108.56  E-value: 6.48e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971 142 NRQRSSTAMTVMADLGERM-------------------------------VRENVPIVPVVYSSfSSFYNTKKKFFTSGT 190
Cdd:COG0204  95 DRSKRRAALRALRQAVEALkageslvifpegtrspdgrllpfktgaarlaLEAGVPIVPVAIDG-TERALPKGFLPRPGK 173

                       170       180       190
                ....*....|....*....|....*....|.
gi 69122971 191 VTVQVLEAIPTSGLTAADVPALVDTCHRAMR 221
Cdd:COG0204 174 VTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-221 6.48e-29

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 108.56  E-value: 6.48e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971 142 NRQRSSTAMTVMADLGERM-------------------------------VRENVPIVPVVYSSfSSFYNTKKKFFTSGT 190
Cdd:COG0204  95 DRSKRRAALRALRQAVEALkageslvifpegtrspdgrllpfktgaarlaLEAGVPIVPVAIDG-TERALPKGFLPRPGK 173

                       170       180       190
                ....*....|....*....|....*....|.
gi 69122971 191 VTVQVLEAIPTSGLTAADVPALVDTCHRAMR 221
Cdd:COG0204 174 VTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-217 1.63e-27

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 103.89  E-value: 1.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  67 VRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRS 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971 147 STAMTVMADLGERM-------------------------------VRENVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQV 195
Cdd:cd07989  81 RSAREALREAIEALkegesvvifpegtrsrdgellpfksgafrlaKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRI 160

                       170       180
                ....*....|....*....|....
gi 69122971 196 LEAIPTSGL--TAADVPALVDTCH 217
Cdd:cd07989 161 GEPIPPEGLelAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-173 2.86e-19

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 80.79  E-value: 2.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971    77 RFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLP---ERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 69122971   154 ADLGERM-------------------------------VRENVPIVPVVYS 173
Cdd:pfam01553  81 EYLVELLregklvvifpegtrsregellpfkkgafrlaIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-168 2.21e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 64.68  E-value: 2.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971     92 CVIVSNHQSILDMMGLMEVLPE---RCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGeRMVRENVPIV 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-ELLKEGEWLL 79
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-168 1.97e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 59.67  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971    75 GLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELL---FLGPVGLIMylgGVFFINRqRSSTAMT 151
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKwipFFGIMLWLT---GAIFIDR-ENIRAIA 76

                          90
                  ....*....|....*..
gi 69122971   152 VMADLGERMVRENVPIV 168
Cdd:TIGR00530  77 TALKAAIEVLKQGRSIG 93
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 37-238 2.88e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 46.93  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971   37 CFTVSAVASLVCLLrhGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCV 116
Cdd:PRK15018  14 SILVCVFGSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  117 QIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADL----------------GER----------------MVREN 164
Cdd:PRK15018  92 TVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVvnhfkkrrisiwmfpeGTRsrgrgllpfktgafhaAIAAG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 69122971  165 VPIVPVVYSSFSSFYNTKKkfFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATA 238
Cdd:PRK15018 172 VPIIPVCVSTTSNKINLNR--LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAG 243
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-221 6.48e-29

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 108.56  E-value: 6.48e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971 142 NRQRSSTAMTVMADLGERM-------------------------------VRENVPIVPVVYSSfSSFYNTKKKFFTSGT 190
Cdd:COG0204  95 DRSKRRAALRALRQAVEALkageslvifpegtrspdgrllpfktgaarlaLEAGVPIVPVAIDG-TERALPKGFLPRPGK 173

                       170       180       190
                ....*....|....*....|....*....|.
gi 69122971 191 VTVQVLEAIPTSGLTAADVPALVDTCHRAMR 221
Cdd:COG0204 174 VTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-217 1.63e-27

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 103.89  E-value: 1.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  67 VRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRS 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971 147 STAMTVMADLGERM-------------------------------VRENVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQV 195
Cdd:cd07989  81 RSAREALREAIEALkegesvvifpegtrsrdgellpfksgafrlaKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRI 160

                       170       180
                ....*....|....*....|....
gi 69122971 196 LEAIPTSGL--TAADVPALVDTCH 217
Cdd:cd07989 161 GEPIPPEGLelAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-173 2.86e-19

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 80.79  E-value: 2.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971    77 RFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLP---ERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 69122971   154 ADLGERM-------------------------------VRENVPIVPVVYS 173
Cdd:pfam01553  81 EYLVELLregklvvifpegtrsregellpfkkgafrlaIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-168 2.21e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 64.68  E-value: 2.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971     92 CVIVSNHQSILDMMGLMEVLPE---RCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGeRMVRENVPIV 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-ELLKEGEWLL 79
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-168 1.97e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 59.67  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971    75 GLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELL---FLGPVGLIMylgGVFFINRqRSSTAMT 151
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKwipFFGIMLWLT---GAIFIDR-ENIRAIA 76

                          90
                  ....*....|....*..
gi 69122971   152 VMADLGERMVRENVPIV 168
Cdd:TIGR00530  77 TALKAAIEVLKQGRSIG 93
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 37-238 2.88e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 46.93  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971   37 CFTVSAVASLVCLLrhGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCV 116
Cdd:PRK15018  14 SILVCVFGSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  117 QIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADL----------------GER----------------MVREN 164
Cdd:PRK15018  92 TVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVvnhfkkrrisiwmfpeGTRsrgrgllpfktgafhaAIAAG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 69122971  165 VPIVPVVYSSFSSFYNTKKkfFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATA 238
Cdd:PRK15018 172 VPIIPVCVSTTSNKINLNR--LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAG 243
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 70-144 7.33e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 45.31  E-value: 7.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  70 FKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVL-------PERCvqIAKRELLFLGPVGLIMYLGGVFFIN 142
Cdd:cd07990   4 FEWLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLAdrfgrlgRLKI--VLKDSLKYPPLGGWGWQLGEFIFLK 81


                ..
gi 69122971 143 RQ 144
Cdd:cd07990  82 RK 83
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 63-147 1.73e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 38.36  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  63 IGWFVRSFKYFY--GLRFEVRDPRrlqearpcVIVSNHQSILDMMGLMEVLPerCVQIAKRELLFLGPVGLIM-YLGGVF 139
Cdd:cd07991   3 VLLFAFGFYVIKvhGKPDPPEAPR--------IIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILrALGCIF 72


                ....*...
gi 69122971 140 FinrQRSS 147
Cdd:cd07991  73 V---DRSE 77
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 70-168 2.98e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 37.39  E-value: 2.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971  70 FKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLM----EVLPERCVQIAKRELLFLGPVgliMYLGGVFFINRQR 145
Cdd:cd06551   6 LNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFllleRGLRRDVYGLMDEELLERYPF---FTRLGAFSVDRDS 82

                        90       100
                ....*....|....*....|...
gi 69122971 146 SSTAMTVMADLGERMVRENVPIV 168
Cdd:cd06551  83 PRSAAKSLKYVARLLSKPGSVVW 105
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 65-167 7.68e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 36.63  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69122971   65 WFVRSFKYFYGLRFEVRDPRRLQEArPCVIVSNHQSILDMMGLMEVlpERCVQIAKRELLFLGP-VGLIMYLGGVFFINR 143
Cdd:PLN02901  26 WATLSTSPFYKIEVEGLENLPSPDE-PAVYVSNHQSFLDIYTLFHL--GRPFKFISKTSIFLIPiIGWAMYMTGHIPLKR 102

                         90       100
                 ....*....|....*....|....
gi 69122971  144 QRSSTAMTVMADLGErMVRENVPI 167
Cdd:PLN02901 103 MDRRSQLECLKRCME-LLKKGASV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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