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Conserved domains on  [gi|691055927|ref|WP_032001238|]
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gamma-glutamyltransferase [Acinetobacter baumannii]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10001375)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

CATH:  3.60.20.40
Gene Ontology:  GO:0016787
SCOP:  4000420

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
92-651 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 440174  Cd Length: 507  Bit Score: 547.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAAN-EFYLi 170
Cdd:COG0405    1 MVATAHPLASQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATpDMYL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 171 rqniyDPNSPAPVpsarRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDA 250
Cdd:COG0405   80 -----DAGDEIPV----RGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 251 NAmATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQtvgddpaktpiTPSLMTLQDLSNYQ 330
Cdd:COG0405  151 GA-AAIFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQA-----------AGGLLTLEDLAAYR 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 331 VKKRDPICTTYRDrYYVCTMPPPSSgGIAVAQTLGILENFDMSLYPPKNPEneggvpdvmGVHLVSEAERLAYADRDKYV 410
Cdd:COG0405  219 AEWREPLSGTYRG-YTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDSAE---------YVHLLAEAMKLAFADRDRYL 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 411 ADTDFVALPAQGipsFIDKNYLKQRAALINPNQSMGVAPAGNFNTAAGvdttveHGTTQFTIVDAYGNVVSMTSTVESSM 490
Cdd:COG0405  288 GDPDFVDVPVEG---LLSPAYAAERAALIDPDRATPSPRPGDPTGPES------GDTTHLSVVDRDGNAVSLTQSIYGGF 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 491 GSFHMVD--GFLLSNQLTDFSANPydstGAPvaNRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTIIQYVVKTL 568
Cdd:COG0405  359 GSGVVVPgtGFLLNNRGDDFSLDP----GHP--NALAPGKRPRSTMSPTIVLKD---GKPVLVFGSPGGSRIPQTVLQVL 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 569 VGALDWNLNAQQATSLVNFGATNSKNTnidssnvqLSL-----VDLIEGLKAKGHGISNTAQTSG-ISMIMkvnINNQSK 642
Cdd:COG0405  430 LNVLDFGMNPQEAVDAPRWHHQGLPDT--------LELeprfpPAVIAALRARGHKVEVVPDWSGgAQAIL---RDPDGV 498

                 ....*....
gi 691055927 643 YAGGVDPRR 651
Cdd:COG0405  499 LEGAADPRR 507
 
Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
92-651 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 547.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAAN-EFYLi 170
Cdd:COG0405    1 MVATAHPLASQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATpDMYL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 171 rqniyDPNSPAPVpsarRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDA 250
Cdd:COG0405   80 -----DAGDEIPV----RGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 251 NAmATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQtvgddpaktpiTPSLMTLQDLSNYQ 330
Cdd:COG0405  151 GA-AAIFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQA-----------AGGLLTLEDLAAYR 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 331 VKKRDPICTTYRDrYYVCTMPPPSSgGIAVAQTLGILENFDMSLYPPKNPEneggvpdvmGVHLVSEAERLAYADRDKYV 410
Cdd:COG0405  219 AEWREPLSGTYRG-YTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDSAE---------YVHLLAEAMKLAFADRDRYL 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 411 ADTDFVALPAQGipsFIDKNYLKQRAALINPNQSMGVAPAGNFNTAAGvdttveHGTTQFTIVDAYGNVVSMTSTVESSM 490
Cdd:COG0405  288 GDPDFVDVPVEG---LLSPAYAAERAALIDPDRATPSPRPGDPTGPES------GDTTHLSVVDRDGNAVSLTQSIYGGF 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 491 GSFHMVD--GFLLSNQLTDFSANPydstGAPvaNRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTIIQYVVKTL 568
Cdd:COG0405  359 GSGVVVPgtGFLLNNRGDDFSLDP----GHP--NALAPGKRPRSTMSPTIVLKD---GKPVLVFGSPGGSRIPQTVLQVL 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 569 VGALDWNLNAQQATSLVNFGATNSKNTnidssnvqLSL-----VDLIEGLKAKGHGISNTAQTSG-ISMIMkvnINNQSK 642
Cdd:COG0405  430 LNVLDFGMNPQEAVDAPRWHHQGLPDT--------LELeprfpPAVIAALRARGHKVEVVPDWSGgAQAIL---RDPDGV 498

                 ....*....
gi 691055927 643 YAGGVDPRR 651
Cdd:COG0405  499 LEGAADPRR 507
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
105-653 1.10e-160

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 471.31  E-value: 1.10e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  105 CDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANEFYLirqniydpNSPAPVP 184
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMF--------DGKGDSK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  185 SARRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDANaMATYFYPDGSPR 264
Cdd:pfam01019  73 LSLTGGLAVGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPG-LRKIFLPTGRVL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  265 KVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQtvgddpaktpiTPSLMTLQDLSNYQVKKRDPICTTYrdR 344
Cdd:pfam01019 152 KAGELLKQPALAKTLELIAEEGPDAFYRGELAQQLVADLQA-----------NGGIITAEDLANYRVKIREPLSADY--G 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  345 YYVCTMPPPSSGGIAVAQTLGILENFDMSlyppknpeneGGVPDVMGVHLVSEAERLAYADRDKYVADTDFVALPAQGip 424
Cdd:pfam01019 219 GYTVYSPPPSSGGIALLQILNILEGFDLS----------SLLNSAEYLHLLIEAMKLAYADRTRYLGDPDFVPVPVEN-- 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  425 sFIDKNYLKQRAALINPNQSMGVAPAGNfntaagvdttvEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHMVD--GFLLS 502
Cdd:pfam01019 287 -LLSPEYAKERAKLINPNAAFPSSYAPE-----------DGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPgtGILLN 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  503 NQLTDFSANP--YDSTGAPVANRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTIIQYVVKTLVGALDWNLNAQQ 580
Cdd:pfam01019 355 NEMDDFSTPPgnAFGLDPSPANAIAPGKRPLSSMAPTIVLDD---GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQ 431
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691055927  581 ATSLVNFGATNSKNTNIDSSNVQlslvDLIEGLKAKGHGISNTAQTSGISMIMKVNINNqSKYAGGVDPRREG 653
Cdd:pfam01019 432 AVDAPRIHHQLPDVLEVEPGFPE----EVLAELEARGHKVKVVEDSSSVGAIQIVRRTG-GVLYAASDPRRDG 499
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
92-650 2.67e-113

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 349.84  E-value: 2.67e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927   92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANefylir 171
Cdd:TIGR00066   2 MVASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKAT------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  172 QNIYDPNSPAPVP-SARRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDA 250
Cdd:TIGR00066  76 RDMFLDKSGNPLPgKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  251 NAMATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVakagQTVGDDpaktpitPSLMTLQDLSNYQ 330
Cdd:TIGR00066 156 EDSKDIFNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESII----DTLQKN-------GGIMTKKDLAAYD 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  331 VKKRDPICTTYRdRYYVCTMPPPSSGGIAVAQTLGILENFDMSLYPPKNPENeggvpdvmgVHLVSEAERLAYADRDKYV 410
Cdd:TIGR00066 225 VEIRKPLSGDYR-GYQVYTTPPPSSGGIHLLQALNILENFDLSQYGDGSAET---------YQLLAEAMKLSYADRSRYL 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  411 ADTDFVALPAQGIpsfIDKNYLKQRAALINPNQsmgVAPAGNFNTAAGvDTTVEHGTTQFTIVDAYGNVVSMTSTVESSM 490
Cdd:TIGR00066 295 GDPEFVDVPLEEL---LDKRYAKELAQSIKINK---VDPKSTIYPGAY-QPNEGSQTTHFSVVDRDGNAVSLTTTINLEF 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  491 GSFHMVD--GFLLSNQLTDFSANPYDstgapvANRVEGGKRPRSTMAPTLVFKGTTPDefyMATGSPGGGTIIQYVVKTL 568
Cdd:TIGR00066 368 GSGVHAPdtGILLNNEMDDFSLKPGG------ANAVEPNKRPLSSMAPTIVLKDGKPD---LVVGSPGGSRIITTVLQTI 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  569 VGALDWNLNAQQATSLVNFgatnSKNTNIDSSNVQLSLV-DLIEGLKAKGHGISnTAQTSGISMIMKVNINNQSKYAGGV 647
Cdd:TIGR00066 439 VRHIDYGMPLAEAVSEPRI----HHQWLPDELRLEKGFPdDVLQLLKDMGHKVT-LKEVFPMGVVQAIRVDPEGWLYGVS 513

                  ...
gi 691055927  648 DPR 650
Cdd:TIGR00066 514 DPR 516
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
58-587 8.73e-79

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 261.77  E-value: 8.73e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  58 SSVVVGSNQNGAPAAPEGAS-GYRLGNTVKY---ADKYMVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSS 133
Cdd:PRK09615  13 AALLSGSCFSAVAAPPAAPPvSYGVEEDVFHpvrAKQGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVTHPQAG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 134 TIAGSGFMMyYDAKTKQVTAYDGRETAPAAANefyliRQNIYDPNSPAPVPSARRSGRSIGVPGVMRLLEQAQKEHGKLK 213
Cdd:PRK09615  93 NLGGGGFML-LRTKNGNTTAIDFREMAPAKAT-----RDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 214 WNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDANAMATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTG 293
Cdd:PRK09615 167 LNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFYKG 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 294 PIAQAIVAKAGQTVGddpaktpitpsLMTLQDLSNYQVKKRDPICTTYRDrYYVCTMPPPSSGGIAVAQTLGILENFDMS 373
Cdd:PRK09615 247 TIADQIAQEMQKNGG-----------LITKEDLAAYKAVERTPISGDYRG-YQVYSMPPPSSGGIHIVQILNILENFDMK 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 374 LYppknpenEGGVPDVMGVhlVSEAERLAYADRDKYVADTDFVALPAQGIPSfidKNYLKQRAALINPNQSmgvAPAGNF 453
Cdd:PRK09615 315 KY-------GFGSADAMQI--MAEAEKYAYADRSEYLGDPDFVKVPWQALTN---KAYAKSIADQIDINKA---KPSSEI 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 454 NTAAgVDTTVEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHMV--DGFLLSNQLTDFSANP-----YDSTGAPvANRVEG 526
Cdd:PRK09615 380 RPGK-LAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAgnSGILLNNQMDDFSAKPgvpnvYGLVGGD-ANAVGP 457
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 691055927 527 GKRPRSTMAPTLVFK-GTTpdefYMATGSPGGGTIIQYVVKTLVGALDWNLNAQQATSLVNF 587
Cdd:PRK09615 458 NKRPLSSMSPTIVVKdGKT----WLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRF 515
 
Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
92-651 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 547.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAAN-EFYLi 170
Cdd:COG0405    1 MVATAHPLASQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATpDMYL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 171 rqniyDPNSPAPVpsarRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDA 250
Cdd:COG0405   80 -----DAGDEIPV----RGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 251 NAmATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQtvgddpaktpiTPSLMTLQDLSNYQ 330
Cdd:COG0405  151 GA-AAIFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQA-----------AGGLLTLEDLAAYR 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 331 VKKRDPICTTYRDrYYVCTMPPPSSgGIAVAQTLGILENFDMSLYPPKNPEneggvpdvmGVHLVSEAERLAYADRDKYV 410
Cdd:COG0405  219 AEWREPLSGTYRG-YTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDSAE---------YVHLLAEAMKLAFADRDRYL 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 411 ADTDFVALPAQGipsFIDKNYLKQRAALINPNQSMGVAPAGNFNTAAGvdttveHGTTQFTIVDAYGNVVSMTSTVESSM 490
Cdd:COG0405  288 GDPDFVDVPVEG---LLSPAYAAERAALIDPDRATPSPRPGDPTGPES------GDTTHLSVVDRDGNAVSLTQSIYGGF 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 491 GSFHMVD--GFLLSNQLTDFSANPydstGAPvaNRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTIIQYVVKTL 568
Cdd:COG0405  359 GSGVVVPgtGFLLNNRGDDFSLDP----GHP--NALAPGKRPRSTMSPTIVLKD---GKPVLVFGSPGGSRIPQTVLQVL 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 569 VGALDWNLNAQQATSLVNFGATNSKNTnidssnvqLSL-----VDLIEGLKAKGHGISNTAQTSG-ISMIMkvnINNQSK 642
Cdd:COG0405  430 LNVLDFGMNPQEAVDAPRWHHQGLPDT--------LELeprfpPAVIAALRARGHKVEVVPDWSGgAQAIL---RDPDGV 498

                 ....*....
gi 691055927 643 YAGGVDPRR 651
Cdd:COG0405  499 LEGAADPRR 507
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
105-653 1.10e-160

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 471.31  E-value: 1.10e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  105 CDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANEFYLirqniydpNSPAPVP 184
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMF--------DGKGDSK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  185 SARRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDANaMATYFYPDGSPR 264
Cdd:pfam01019  73 LSLTGGLAVGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPG-LRKIFLPTGRVL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  265 KVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQtvgddpaktpiTPSLMTLQDLSNYQVKKRDPICTTYrdR 344
Cdd:pfam01019 152 KAGELLKQPALAKTLELIAEEGPDAFYRGELAQQLVADLQA-----------NGGIITAEDLANYRVKIREPLSADY--G 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  345 YYVCTMPPPSSGGIAVAQTLGILENFDMSlyppknpeneGGVPDVMGVHLVSEAERLAYADRDKYVADTDFVALPAQGip 424
Cdd:pfam01019 219 GYTVYSPPPSSGGIALLQILNILEGFDLS----------SLLNSAEYLHLLIEAMKLAYADRTRYLGDPDFVPVPVEN-- 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  425 sFIDKNYLKQRAALINPNQSMGVAPAGNfntaagvdttvEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHMVD--GFLLS 502
Cdd:pfam01019 287 -LLSPEYAKERAKLINPNAAFPSSYAPE-----------DGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPgtGILLN 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  503 NQLTDFSANP--YDSTGAPVANRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTIIQYVVKTLVGALDWNLNAQQ 580
Cdd:pfam01019 355 NEMDDFSTPPgnAFGLDPSPANAIAPGKRPLSSMAPTIVLDD---GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQ 431
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691055927  581 ATSLVNFGATNSKNTNIDSSNVQlslvDLIEGLKAKGHGISNTAQTSGISMIMKVNINNqSKYAGGVDPRREG 653
Cdd:pfam01019 432 AVDAPRIHHQLPDVLEVEPGFPE----EVLAELEARGHKVKVVEDSSSVGAIQIVRRTG-GVLYAASDPRRDG 499
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
92-650 2.67e-113

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 349.84  E-value: 2.67e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927   92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANefylir 171
Cdd:TIGR00066   2 MVASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKAT------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  172 QNIYDPNSPAPVP-SARRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDA 250
Cdd:TIGR00066  76 RDMFLDKSGNPLPgKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  251 NAMATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVakagQTVGDDpaktpitPSLMTLQDLSNYQ 330
Cdd:TIGR00066 156 EDSKDIFNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESII----DTLQKN-------GGIMTKKDLAAYD 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  331 VKKRDPICTTYRdRYYVCTMPPPSSGGIAVAQTLGILENFDMSLYPPKNPENeggvpdvmgVHLVSEAERLAYADRDKYV 410
Cdd:TIGR00066 225 VEIRKPLSGDYR-GYQVYTTPPPSSGGIHLLQALNILENFDLSQYGDGSAET---------YQLLAEAMKLSYADRSRYL 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  411 ADTDFVALPAQGIpsfIDKNYLKQRAALINPNQsmgVAPAGNFNTAAGvDTTVEHGTTQFTIVDAYGNVVSMTSTVESSM 490
Cdd:TIGR00066 295 GDPEFVDVPLEEL---LDKRYAKELAQSIKINK---VDPKSTIYPGAY-QPNEGSQTTHFSVVDRDGNAVSLTTTINLEF 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  491 GSFHMVD--GFLLSNQLTDFSANPYDstgapvANRVEGGKRPRSTMAPTLVFKGTTPDefyMATGSPGGGTIIQYVVKTL 568
Cdd:TIGR00066 368 GSGVHAPdtGILLNNEMDDFSLKPGG------ANAVEPNKRPLSSMAPTIVLKDGKPD---LVVGSPGGSRIITTVLQTI 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  569 VGALDWNLNAQQATSLVNFgatnSKNTNIDSSNVQLSLV-DLIEGLKAKGHGISnTAQTSGISMIMKVNINNQSKYAGGV 647
Cdd:TIGR00066 439 VRHIDYGMPLAEAVSEPRI----HHQWLPDELRLEKGFPdDVLQLLKDMGHKVT-LKEVFPMGVVQAIRVDPEGWLYGVS 513

                  ...
gi 691055927  648 DPR 650
Cdd:TIGR00066 514 DPR 516
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
58-587 8.73e-79

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 261.77  E-value: 8.73e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  58 SSVVVGSNQNGAPAAPEGAS-GYRLGNTVKY---ADKYMVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSS 133
Cdd:PRK09615  13 AALLSGSCFSAVAAPPAAPPvSYGVEEDVFHpvrAKQGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVTHPQAG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 134 TIAGSGFMMyYDAKTKQVTAYDGRETAPAAANefyliRQNIYDPNSPAPVPSARRSGRSIGVPGVMRLLEQAQKEHGKLK 213
Cdd:PRK09615  93 NLGGGGFML-LRTKNGNTTAIDFREMAPAKAT-----RDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 214 WNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDANAMATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTG 293
Cdd:PRK09615 167 LNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFYKG 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 294 PIAQAIVAKAGQTVGddpaktpitpsLMTLQDLSNYQVKKRDPICTTYRDrYYVCTMPPPSSGGIAVAQTLGILENFDMS 373
Cdd:PRK09615 247 TIADQIAQEMQKNGG-----------LITKEDLAAYKAVERTPISGDYRG-YQVYSMPPPSSGGIHIVQILNILENFDMK 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 374 LYppknpenEGGVPDVMGVhlVSEAERLAYADRDKYVADTDFVALPAQGIPSfidKNYLKQRAALINPNQSmgvAPAGNF 453
Cdd:PRK09615 315 KY-------GFGSADAMQI--MAEAEKYAYADRSEYLGDPDFVKVPWQALTN---KAYAKSIADQIDINKA---KPSSEI 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 454 NTAAgVDTTVEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHMV--DGFLLSNQLTDFSANP-----YDSTGAPvANRVEG 526
Cdd:PRK09615 380 RPGK-LAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAgnSGILLNNQMDDFSAKPgvpnvYGLVGGD-ANAVGP 457
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 691055927 527 GKRPRSTMAPTLVFK-GTTpdefYMATGSPGGGTIIQYVVKTLVGALDWNLNAQQATSLVNF 587
Cdd:PRK09615 458 NKRPLSSMSPTIVVKdGKT----WLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRF 515
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
104-561 2.48e-49

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 181.43  E-value: 2.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 104 GCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAkTKQVTAYDGRETAPAAANEfylirqNIYDPNspapV 183
Cdd:PLN02198  47 GMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTLIKLA-NGEEIAYDSRETAPLSATE------NMYGGN----V 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 184 PSARRSGRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDaNAMATYFYPDGSP 263
Cdd:PLN02198 116 ELKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYLYMQMNATRSDILAD-KGLSDLFVSNGEL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 264 RKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQTVGddpaktpitpsLMTLQDLSNYQVKKRDPICTTYRD 343
Cdd:PLN02198 195 KKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRDIQKSGG-----------IITLKDLQSYRVKVKEPLSADILG 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 344 rYYVCTMPPPSSGGIAVAQTLGILENFDMslyppknPEnegGVPDVMGVHLVSEAERLAYADRDKyVADTDFVALpAQGI 423
Cdd:PLN02198 264 -YRVLGMPPPSSGGAAMMLILNILAQYGI-------PS---GVSGPLGVHRLIEALKHAFAVRMN-LGDPDFVDV-TKVV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 424 PSFIDKNYLKQRAALINPNQSMGvaP---AGNFNTAAgvdttvEHGTTQFTIVDAYGNVVSMTSTVESSMGSFHM--VDG 498
Cdd:PLN02198 331 SDMLSPKFAQDLKSKINDNKTFD--PkhyGGRWNQID------DHGTSHLSIIDSERNAVSMTSTINGYFGALMLspSTG 402
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 691055927 499 FLLSNQLTDFSAnPYDSTGAP------VANRVEGGKRPRSTMAPTLVFKGttpDEFYMATGSPGGGTII 561
Cdd:PLN02198 403 IVLNNEMDDFSI-PMKSGGNLdvpppaPANFIRPGKRPLSSMTPTIVLKD---GKVKAAVGASGGANII 467
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
92-653 5.69e-43

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 164.47  E-value: 5.69e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927  92 MVVANTPLAVKAGCDVLKAGGSAVDAAVAVQAVLGLVEPQSSTIAGSGFMMYYDAKTKQVTAYDGRETAPAAANefylir 171
Cdd:PLN02180  84 VVAADDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAAS------ 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 172 QNIYDPNSPAPVPSArrsgRSIGVPGVMRLLEQAQKEHGKLKWNQLFGEAIGLADNGFRIPGRLADAIASNASNLALDAn 251
Cdd:PLN02180 158 KDMYKNDASAKSLGA----LSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAMILKDP- 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 252 AMATYFYPDGSPRKVGETMTNKAYARTLEALASQGANALHTGPIAQAIVAKAGQTVGddpaktpitpsLMTLQDLSNYQV 331
Cdd:PLN02180 233 GLRSVFSRNGQVLKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKKAGG-----------IITMDDLRSYEV 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 332 KKRDPICTTYRDrYYVCTMPPPSSGGIAVAQTLGILENFDmSLYPPKNPEneggvpdvMGVHLVSEAERLAYADRDKyVA 411
Cdd:PLN02180 302 LVTDAMSVDVMG-YTIHGMPPPSGGTLGFSMVIDILDSYS-NLYTASGRE--------LGLHRLIEAMKHMFAARMD-LG 370
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 412 DTDFVALpAQGIPSFIDKNYLKQRAALINPNQSMgvAPAGNFNTAAGVDttvEHGTTQFTIVDAYGNVVSMTSTVESSMG 491
Cdd:PLN02180 371 DPEFVNI-TNAMNQMLSKAHAEEIQKRIFDNTTF--PPEYYLNRWSQLR---DQGTSHFCIVDADRNSVSMTSTVNYGFG 444
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 492 S--FHMVDGFLLSNQLTDFSA----NPYDSTGAPvANRVEGGKRPRSTMAPTLVfkgTTPDEFYMATGSPGGGTIIQYVV 565
Cdd:PLN02180 445 AgvLSPSTGIVLNNEMDDFSTpaeiTPDMLPPAP-TNFIEPNKRPLSSMTPLVI---TKDGEFVAALGGAGGMHIIPAVL 520
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691055927 566 KTLVGALDWNLNAQQA--------------TSLVNFGATNSKNTNIdSSNVQLSLVDLIEGLKAKGHG------ISNTAQ 625
Cdd:PLN02180 521 QVFLNCFVLNMKPKEAvesariyhrlipnvVSYENFTAINGDHIGV-SEDTKMFLAERGHELKALSGGaivqliVQSFKE 599
                        570       580       590
                 ....*....|....*....|....*....|....*
gi 691055927 626 TSGISMIMKV--NINNQSKYAGGV-----DPRREG 653
Cdd:PLN02180 600 EKEEEMIIEIgrKIGKKSKPLKGLltavcDPRKDG 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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