|
Name |
Accession |
Description |
Interval |
E-value |
| GPI_EPT_2 |
cd16024 |
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ... |
66-335 |
1.94e-165 |
|
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293748 [Multi-domain] Cd Length: 274 Bit Score: 484.76 E-value: 1.94e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 66 FKRVVIVLIDALREDFVFSSNgrRFMPYTRHVVEKGSSHSFIAKARPPTVTMPRIKALTTGSIPGFIDVVMNLNSPVLLE 145
Cdd:cd16024 4 FDKLVFMVIDALRADFVFGPD--SNMPFTQSLINSGSALAFTAKAQPPTVTMPRIKALTTGSIPSFLDVVLNFASSLLEE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 146 DNLIWQAKSAGKRIIFYGDDTWVRLFPKHFMEQDGTTSFFVSDYTEVDNNVTRHLDSTLKRDDWDILILHYLGLDHIGHI 225
Cdd:cd16024 82 DNWLSQLKAAGKKIVFYGDDTWLKLFPGSFTRSDGTTSFFVSDFTEVDNNVTRHLDSELSRDDWDVLILHYLGLDHIGHL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 226 SGPHSSLIGPKLMEMDDIIKKIHASLisKESEGTLPNLLVVCGDHGMSETGSHGGSSEQEINTALVLISPAFRRKVGLER 305
Cdd:cd16024 162 EGPKSPLMPPKLKEMDDVIKRIYESL--EEQSSNNPTLLVVCGDHGMTDAGNHGGSSPGETSVPLLFISPKFSSKPSNAD 239
|
250 260 270
....*....|....*....|....*....|....*
gi 688584443 306 -----PAVVEQVDLAPTLALGLGLPISQNSVGRLI 335
Cdd:cd16024 240 gelsyYETVQQVDLAPTLALLLGLPIPKNSVGVLI 274
|
|
| PIGO_PIGG |
pfam19316 |
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the ... |
743-953 |
4.05e-16 |
|
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.
Pssm-ID: 437148 Cd Length: 423 Bit Score: 81.86 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 743 ARFVYVFVLGILFTGVKDLLRSQVMSSAVDSGRLksrgLWEVYSgvvLLVALLFRAHNLPTLacclLVQTIMAQFIwKKL 822
Cdd:pfam19316 205 ARVVFLGLALGAVYAVYRERARSRRARGGGSARL----LHELLT---LFLITQSRATNIPLF----LLFRLQLEFL-SSL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 823 HYDAAQTTIMHYWFGQAFFYFQGNSNNIGTVDISVGFVGLESYVEAPAIILTALSTYAGPLLWACHLLCYLSSQTDRvvn 902
Cdd:pfam19316 273 DLSPTEITTTSLLLQYASFFAFGGSNAISSVDLSNAYNGVSGYNVVAVGVLTFVSNWAGPIWWTSATNLLLLRKRRR--- 349
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688584443 903 glGHGSYCFALLRSIPAVF---YVVLV----TALRYHLFIWSVFSPKLLYE-----AMHTLIT 953
Cdd:pfam19316 350 --GEGRGVFFQHLALLTLFvaaSLVSVmaacTALRTHLFIWTVFSPKYLYTmawslGQHLLVN 410
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
67-325 |
1.38e-14 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 76.71 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 67 KRVVIVLIDALREDFVfssnGRRFMPYTRHVVEKGSSHsfiAKARP--PTVTMPRIKALTTGS------IPGF------I 132
Cdd:COG1524 24 KKVVLILVDGLRADLL----ERAHAPNLAALAARGVYA---RPLTSvfPSTTAPAHTTLLTGLypgehgIVGNgwydpeL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 133 DVVMNLNSPVLLEDNL--------IWQ-AKSAGKR--IIF---YGDDTWVRL-FPKHFmeqDGTTSFFVSDYTevDNNVT 197
Cdd:COG1524 97 GRVVNSLSWVEDGFGSnsllpvptIFErARAAGLTtaAVFwpsFEGSGLIDAaRPYPY---DGRKPLLGNPAA--DRWIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 198 RHLDSTLKRDDWDILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLiskESEGTLPN-LLVVCGDHGMSET- 275
Cdd:COG1524 172 AAALELLREGRPDLLLVYLPDLDYAGHRYGPDSPEYRAALREVDAALGRLLDAL---KARGLYEGtLVIVTADHGMVDVp 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 276 ------------------------------------------------------------------------------GS 277
Cdd:COG1524 249 pdidlnrlrlagllavragesahlylkdgadaevrallglparvltreelaaghfgphrigdlvlvakpgwaldaplkGS 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 688584443 278 HGGSSEQEINTALVLISPAFRRKvglerpavVEQVDLAPTLALGLGLP 325
Cdd:COG1524 329 HGGLPDEEMRVPLLASGPGFRPG--------VRNVDVAPTIARLLGLP 368
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
69-275 |
2.04e-09 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 60.51 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 69 VVIVLIDALREDFVFSsngRRFMPYTRHVVEKGSShsfIAKARP--PTVTMPRIKALTTGSIPG--------FID----- 133
Cdd:pfam01663 1 LLVISLDGFRADYLDR---FELTPNLAALAKEGVS---APNLTPvfPTLTFPNHYTLVTGLYPGshgivgntFYDpktge 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 134 ----VVMNLNSPVLLEDNLIWQ-AKSAGKR--IIFYG----DDTWVRLFPKHFMEQD--GTTSFFVSDYTEVDNNVTRHL 200
Cdd:pfam01663 75 ylvfVISDPEDPRWWQGEPIWDtAAKAGVRaaALFWPgsevDYSTYYGTPPRYLKDDynNSVPFEDRVDTAVLQTWLDLP 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688584443 201 DSTLKRDDWDILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLisKESEGTLPNLLVVCGDHGMSET 275
Cdd:pfam01663 155 FADVAAERPDLLLVYLEEPDYAGHRYGPDSPEVEDALRRVDRAIGDLLEAL--DERGLFEDTNVIVVSDHGMTPV 227
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GPI_EPT_2 |
cd16024 |
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is ... |
66-335 |
1.94e-165 |
|
GPI ethanolamine phosphate transferase 2; PIG-G; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293748 [Multi-domain] Cd Length: 274 Bit Score: 484.76 E-value: 1.94e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 66 FKRVVIVLIDALREDFVFSSNgrRFMPYTRHVVEKGSSHSFIAKARPPTVTMPRIKALTTGSIPGFIDVVMNLNSPVLLE 145
Cdd:cd16024 4 FDKLVFMVIDALRADFVFGPD--SNMPFTQSLINSGSALAFTAKAQPPTVTMPRIKALTTGSIPSFLDVVLNFASSLLEE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 146 DNLIWQAKSAGKRIIFYGDDTWVRLFPKHFMEQDGTTSFFVSDYTEVDNNVTRHLDSTLKRDDWDILILHYLGLDHIGHI 225
Cdd:cd16024 82 DNWLSQLKAAGKKIVFYGDDTWLKLFPGSFTRSDGTTSFFVSDFTEVDNNVTRHLDSELSRDDWDVLILHYLGLDHIGHL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 226 SGPHSSLIGPKLMEMDDIIKKIHASLisKESEGTLPNLLVVCGDHGMSETGSHGGSSEQEINTALVLISPAFRRKVGLER 305
Cdd:cd16024 162 EGPKSPLMPPKLKEMDDVIKRIYESL--EEQSSNNPTLLVVCGDHGMTDAGNHGGSSPGETSVPLLFISPKFSSKPSNAD 239
|
250 260 270
....*....|....*....|....*....|....*
gi 688584443 306 -----PAVVEQVDLAPTLALGLGLPISQNSVGRLI 335
Cdd:cd16024 240 gelsyYETVQQVDLAPTLALLLGLPIPKNSVGVLI 274
|
|
| GPI_EPT_3 |
cd16023 |
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is ... |
66-335 |
3.44e-99 |
|
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293747 Cd Length: 289 Bit Score: 312.96 E-value: 3.44e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 66 FKRVVIVLIDALREDFVF-------SSNGRRF---MPYTRHVVEKGSSHSFIAK--ARPPTVTMPRIKALTTGSIPGFID 133
Cdd:cd16023 4 FDKVVLLLIDALRYDFVLpddenppSENSLYYhnkLPVLEELLKSQPNNSRLFKfiADPPTTTLQRLKGLTTGSLPTFID 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 134 VVMNLNSPVLLEDNLIWQAKSAGKRIIFYGDDTWVRLFPKHFMEQDGTTSFFVSDYTEVDNNVTRHLDSTLKR-DDWDIL 212
Cdd:cd16023 84 AGSNFASSAIVEDNLLKQLKLAGKRIVFMGDDTWTSLFPNQFDRSYPFPSFNVKDLDTVDNGVLKHLFPELQSeDDWDLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 213 ILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIhaslISKESEGTlpnLLVVCGDHGMSETGSHGGSSEQEINTALVL 292
Cdd:cd16023 164 IAHFLGVDHVGHRYGPNHPEMARKLTQMDQFIRDI----IERLDDDT---LLLVFGDHGMTETGDHGGDSDEEVDAALFA 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 688584443 293 ISPAFRRKVGLERPA----------VVEQVDLAPTLALGLGLPISQNSVGRLI 335
Cdd:cd16023 237 YSKRPFNNSDEPIESngpgdpskvrSVPQIDLVPTLSLLLGLPIPFSNLGTVI 289
|
|
| GPI_EPT |
cd16019 |
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in ... |
66-335 |
8.56e-80 |
|
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293743 [Multi-domain] Cd Length: 292 Bit Score: 261.14 E-value: 8.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 66 FKRVVIVLIDALREDFVFSSNGRR-FMPYTRHVVE-KGSSHSFIAKARPPTVTMPRIKALTTGSIPGFIDVVMNLNSPVL 143
Cdd:cd16019 4 YDKVVLIVIDGLRYDLAVNVNKQSsFFSFLQKLNEqPNNSFLALSFADPPTVTGPRLKALTTGNPPTFLDLISNFASSEI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 144 LEDNLIWQAKSAGKRIIFYGDDTWVRLFPKHFMEQDGTTSFFVSDYTEVDNNVTRHLDSTLK----RDDWDILILHYLGL 219
Cdd:cd16019 84 KEDNIIRQLKKNGKKILFYGDDTWLDLFPEIFTYKFTITSFNIRDMHDVDPIFYNHINDNLDeniyYDNWDFIILHFLGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 220 DHIGHISG-PHSSLIGPKLMEMDDIIKKIhaslISKESEGTlpnLLVVCGDHGMSETGSHGGSSEQEINTALVLISP--- 295
Cdd:cd16019 164 DHLGHKHNtTSSPELEKKLDQMDNLIRDI----YDRMDNDT---LLVVVSDHGMNNDGNHGGSSTEETSSFFFFISKkgf 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 688584443 296 ----------------AFRRKVGLERPAVVEQVDLAPTLALGLGLPISQNSVGRLI 335
Cdd:cd16019 237 fkkrpidqiekikqnnEQQKIDPSEYIRIIYQIDILPTICYLLGIPIPFNNIGIII 292
|
|
| GPI_EPT_1 |
cd16020 |
GPI ethanolamine phosphate transferase 1; PIG-N; Ethanolamine phosphate transferase is ... |
60-334 |
1.43e-25 |
|
GPI ethanolamine phosphate transferase 1; PIG-N; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293744 Cd Length: 294 Bit Score: 108.06 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 60 RAPAllfKRVVIVLIDALREDFVFSSNGRRfMPYTRHVVEK----GSSHSfiakaRPPTVTMPRIKALTTG------SI- 128
Cdd:cd16020 1 PPPA---KRLVVFVADGLRADTFFENNCSR-APFLRKIFLNqglwGISHT-----RVPTESRPGHVALFAGfyedpsAVt 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 129 ------PGFIDVVMNlNSpvllednliwqaksagKRIIFYGDDTWVRLFPK------HFMEQDGTTSFFVSDYTEVD--- 193
Cdd:cd16020 72 kgwkenPVEFDSVFN-RS----------------RRSWAWGSPDILPMFPKgatggkVLTYIYPEEDFDSTDASELDewv 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 194 -NNVTRHLDSTLKRDDWD------ILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLISKESEGTLPNLLVv 266
Cdd:cd16020 135 fDKVEEFLANASSNKTELlnqdglVFFLHLLGLDTNGHAHKPYSKEYLENIRYVDKGIEKTYPLIEEYFNDGRTAYIFT- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 267 cGDHGMSETGSHGGSSEQEINTALVL-----------ISPAFRRKVGLERPA--VVEQVDLAPTLALGLGLPISQNSVGR 333
Cdd:cd16020 214 -SDHGMTDWGSHGDGSPDETETPFIAwgagikhptpgRGPSFSANWGGLRLPrhDLDQADLAPLMSALLGLPPPVNSVGI 292
|
.
gi 688584443 334 L 334
Cdd:cd16020 293 L 293
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
67-323 |
6.09e-18 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 84.94 E-value: 6.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 67 KRVVIVLIDALREDFVfssNGRRFMPYTRHVVEKGSShsfIAKARP--PTVTMPRIKALTTGSIP---GFIDVVM---NL 138
Cdd:cd16018 1 PPLIVISIDGFRWDYL---DRAGLTPNLKRLAEEGVR---AKYVKPvfPTLTFPNHYSIVTGLYPeshGIVGNYFydpKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 139 NSPVLLEDNL----------IWQ-AKSAGKR--IIF--------YGDDTWVRLFPKHFMEQDGTTSFfvsdyTEVDNNVT 197
Cdd:cd16018 75 NEEFSDSDWVwdpwwiggepIWVtAEKAGLKtaSYFwpgsevaiIGYNPTPIPLGGYWQPYNDSFPF-----EERVDTIL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 198 RHLDstlkRDDWDILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLiskESEGTLPNL-LVVCGDHGMSETG 276
Cdd:cd16018 150 EWLD----LERPDLILLYFEEPDSAGHKYGPDSPEVNEALKRVDRRLGYLIEAL---KERGLLDDTnIIVVSDHGMTDVG 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 688584443 277 SHGGS-SEQEINTALVLISPAFRRKVGLERpavVEQVDLAPTLALGLG 323
Cdd:cd16018 223 THGYDnELPDMRAIFIARGPAFKKGKKLGP---FRNVDIYPLMCNLLG 267
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
67-319 |
3.36e-16 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 79.00 E-value: 3.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 67 KRVVIVLIDALREDFVF-SSNGRRFMPYTRhvVEKGSSHSFIAK-ARPPTVTMPRIKALTTGSIPGFIDVVmnlnspvll 144
Cdd:cd00016 1 KHVVLIVLDGLGADDLGkAGNPAPTTPNLK--RLASEGATFNFRsVSPPTSSAPNHAALLTGAYPTLHGYT--------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 145 ednlIWQAKSAGKRIIFYGDDTWVRLFPKHFMEQDGTTSFFvsdytevdnnvtrHLDSTLKRDD---WDILILHYLGLDH 221
Cdd:cd00016 70 ----GNGSADPELPSRAAGKDEDGPTIPELLKQAGYRTGVI-------------GLLKAIDETSkekPFVLFLHFDGPDG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 222 IGHISGPHSSLIGPKLMEMDD-IIKKIHASLISKESEGTlpnLLVVCGDHGMSETGSHG--------GSSEQEINTALVL 292
Cdd:cd00016 133 PGHAYGPNTPEYYDAVEEIDErIGKVLDALKKAGDADDT---VIIVTADHGGIDKGHGGdpkadgkaDKSHTGMRVPFIA 209
|
250 260
....*....|....*....|....*..
gi 688584443 293 ISPafRRKVGLERPAVVEQVDLAPTLA 319
Cdd:cd00016 210 YGP--GVKKGGVKHELISQYDIAPTLA 234
|
|
| PIGO_PIGG |
pfam19316 |
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the ... |
743-953 |
4.05e-16 |
|
GPI ethanolamine phosphate transferase membrane region; This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.
Pssm-ID: 437148 Cd Length: 423 Bit Score: 81.86 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 743 ARFVYVFVLGILFTGVKDLLRSQVMSSAVDSGRLksrgLWEVYSgvvLLVALLFRAHNLPTLacclLVQTIMAQFIwKKL 822
Cdd:pfam19316 205 ARVVFLGLALGAVYAVYRERARSRRARGGGSARL----LHELLT---LFLITQSRATNIPLF----LLFRLQLEFL-SSL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 823 HYDAAQTTIMHYWFGQAFFYFQGNSNNIGTVDISVGFVGLESYVEAPAIILTALSTYAGPLLWACHLLCYLSSQTDRvvn 902
Cdd:pfam19316 273 DLSPTEITTTSLLLQYASFFAFGGSNAISSVDLSNAYNGVSGYNVVAVGVLTFVSNWAGPIWWTSATNLLLLRKRRR--- 349
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688584443 903 glGHGSYCFALLRSIPAVF---YVVLV----TALRYHLFIWSVFSPKLLYE-----AMHTLIT 953
Cdd:pfam19316 350 --GEGRGVFFQHLALLTLFvaaSLVSVmaacTALRTHLFIWTVFSPKYLYTmawslGQHLLVN 410
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
67-325 |
1.38e-14 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 76.71 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 67 KRVVIVLIDALREDFVfssnGRRFMPYTRHVVEKGSSHsfiAKARP--PTVTMPRIKALTTGS------IPGF------I 132
Cdd:COG1524 24 KKVVLILVDGLRADLL----ERAHAPNLAALAARGVYA---RPLTSvfPSTTAPAHTTLLTGLypgehgIVGNgwydpeL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 133 DVVMNLNSPVLLEDNL--------IWQ-AKSAGKR--IIF---YGDDTWVRL-FPKHFmeqDGTTSFFVSDYTevDNNVT 197
Cdd:COG1524 97 GRVVNSLSWVEDGFGSnsllpvptIFErARAAGLTtaAVFwpsFEGSGLIDAaRPYPY---DGRKPLLGNPAA--DRWIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 198 RHLDSTLKRDDWDILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLiskESEGTLPN-LLVVCGDHGMSET- 275
Cdd:COG1524 172 AAALELLREGRPDLLLVYLPDLDYAGHRYGPDSPEYRAALREVDAALGRLLDAL---KARGLYEGtLVIVTADHGMVDVp 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 276 ------------------------------------------------------------------------------GS 277
Cdd:COG1524 249 pdidlnrlrlagllavragesahlylkdgadaevrallglparvltreelaaghfgphrigdlvlvakpgwaldaplkGS 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 688584443 278 HGGSSEQEINTALVLISPAFRRKvglerpavVEQVDLAPTLALGLGLP 325
Cdd:COG1524 329 HGGLPDEEMRVPLLASGPGFRPG--------VRNVDVAPTIARLLGLP 368
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
69-275 |
2.04e-09 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 60.51 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 69 VVIVLIDALREDFVFSsngRRFMPYTRHVVEKGSShsfIAKARP--PTVTMPRIKALTTGSIPG--------FID----- 133
Cdd:pfam01663 1 LLVISLDGFRADYLDR---FELTPNLAALAKEGVS---APNLTPvfPTLTFPNHYTLVTGLYPGshgivgntFYDpktge 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 134 ----VVMNLNSPVLLEDNLIWQ-AKSAGKR--IIFYG----DDTWVRLFPKHFMEQD--GTTSFFVSDYTEVDNNVTRHL 200
Cdd:pfam01663 75 ylvfVISDPEDPRWWQGEPIWDtAAKAGVRaaALFWPgsevDYSTYYGTPPRYLKDDynNSVPFEDRVDTAVLQTWLDLP 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688584443 201 DSTLKRDDWDILILHYLGLDHIGHISGPHSSLIGPKLMEMDDIIKKIHASLisKESEGTLPNLLVVCGDHGMSET 275
Cdd:pfam01663 155 FADVAAERPDLLLVYLEEPDYAGHRYGPDSPEVEDALRRVDRAIGDLLEAL--DERGLFEDTNVIVVSDHGMTPV 227
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
67-333 |
3.82e-09 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 58.71 E-value: 3.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 67 KRVVIVLIDALREDFV---------------FSSNGRRFmpyTRHVVekGSSHsfiakarpptvTMPRIKALTTGSIP-- 129
Cdd:cd16148 1 MNVILIVIDSLRADHLgcygydrvttpnldrLAAEGVVF---DNHYS--GSNP-----------TLPSRFSLFTGLYPfy 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 130 -GFIDVVMNLNSPVLLEdnliwQAKSAGKRIIFYGDDTWVRLFP------KHFMEQDGTTSFFVSDYTEVDNNVTRH--- 199
Cdd:cd16148 65 hGVWGGPLEPDDPTLAE-----ILRKAGYYTAAVSSNPHLFGGPgfdrgfDTFEDFRGQEGDPGEEGDERAERVTDRale 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 200 -LDSTLKRDDWdILILHYLGldhighisgPHssliGP-----KLMEMDDIIKKIHASLiskESEGTLPN-LLVVCGDHGM 272
Cdd:cd16148 140 wLDRNADDDPF-FLFLHYFD---------PH----EPylydaEVRYVDEQIGRLLDKL---KELGLLEDtLVIVTSDHGE 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688584443 273 S-----ETGSHGGS-SEQEINTALVLISPAFRRkvGLERPAVVEQVDLAPTLALGLGLPISQNSVGR 333
Cdd:cd16148 203 EfgehgLYWGHGSNlYDEQLHVPLIIRWPGKEP--GKRVDALVSHIDIAPTLLDLLGVEPPDYSDGR 267
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
239-325 |
9.51e-03 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 38.96 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688584443 239 EMDDIIKKIHASLiskESEGTLPNLLVV-CGDHGMSeTGSHGGSS------EQEINTALVLISPAfRRKVGLERPAVVEQ 311
Cdd:cd16022 139 AIDDQIGRILDAL---EELGLLDNTLIVfTSDHGDM-LGDHGLRGkkgslyEGGIRVPFIVRWPG-KIPAGQVSDALVSL 213
|
90
....*....|....*.
gi 688584443 312 VDLAPTL--ALGLGLP 325
Cdd:cd16022 214 LDLLPTLldLAGIEPP 229
|
|
| |
