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Conserved domains on  [gi|68800360|ref|NP_004941|]
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epiphycan precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-301 6.25e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 229
Cdd:COG4886 123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68800360 230 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 301
Cdd:COG4886 199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
121-145 4.37e-04

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 4.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 68800360    121 CTCISTTVYCDDHELDAIPP-LPKNT 145
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-301 6.25e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 229
Cdd:COG4886 123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68800360 230 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 301
Cdd:COG4886 199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
151-203 3.32e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 68800360   151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
126-317 1.86e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  126 TTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINkndfASLSD-LKRIDLTSNLISEIDE-------------DAFRKL 190
Cdd:PRK15370 202 TTLILDNNELKSLPEnLQGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPErlpsalqsldlfhNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  191 PQ-----LRELVLRDNKIRQLPE-LPTTLTFIDISNNRLgrkgikqEAFKDMY--DLHHLYLTDNNLDHIPLPLPENLRA 262
Cdd:PRK15370 278 PEnlpeeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSL-------TALPETLppGLKTLEAGENALTSLPASLPPELQV 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 68800360  263 LHLQNNNILEMHEDTFCNVKNLTYIRKALedIRLDGN-PINLSKTPQAYMCLPRLP 317
Cdd:PRK15370 351 LDVSKNQITVLPETLPPTITTLDVSRNAL--TNLPENlPAALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 153-301 1.37e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKINknDFASLSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKI----------RQLPELPTTLTFIDISNNR 222
Cdd:cd21340  56 NQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekltfdpRSLAALSNSLRVLNISGNN 131

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68800360 223 LGrkgikqeafkDMYDLHHLYltdnnldhiplplpeNLRALHLQNNNILEMhEDTFCNVKNLTYirkaLEDIRLDGNPI 301
Cdd:cd21340 132 ID----------SLEPLAPLR---------------NLEQLDASNNQISDL-EELLDLLSSWPS----LRELDLTGNPV 180
LRRNT smart00013
Leucine rich repeat N-terminal domain;
121-145 4.37e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 4.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 68800360    121 CTCISTTVYCDDHELDAIPP-LPKNT 145
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 121-142 5.28e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 5.28e-04
                          10        20
                  ....*....|....*....|...
gi 68800360   121 CTCISTTVYCDDHELDAIPP-LP 142
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-301 6.25e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 229
Cdd:COG4886 123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68800360 230 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 301
Cdd:COG4886 199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
151-203 3.32e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 68800360   151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
126-317 1.86e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  126 TTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINkndfASLSD-LKRIDLTSNLISEIDE-------------DAFRKL 190
Cdd:PRK15370 202 TTLILDNNELKSLPEnLQGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPErlpsalqsldlfhNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  191 PQ-----LRELVLRDNKIRQLPE-LPTTLTFIDISNNRLgrkgikqEAFKDMY--DLHHLYLTDNNLDHIPLPLPENLRA 262
Cdd:PRK15370 278 PEnlpeeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSL-------TALPETLppGLKTLEAGENALTSLPASLPPELQV 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 68800360  263 LHLQNNNILEMHEDTFCNVKNLTYIRKALedIRLDGN-PINLSKTPQAYMCLPRLP 317
Cdd:PRK15370 351 LDVSKNQITVLPETLPPTITTLDVSRNAL--TNLPENlPAALQIMQASRNNLVRLP 404
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-322 6.45e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 6.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKInKNDFASLSDLKRIDLTSNLISEIDEDaFRKLPQLRELVLRDNKIRQLPELP--TTLTFIDISNNRLgrKGIKQ 230
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQL--TDLPP 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 231 EAfkDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFcNVKNLTYIRKALEDIRLDGNPINLSKTPQAY 310
Cdd:COG4886 268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL-LILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                       170
                ....*....|..
gi 68800360 311 MCLPRLPVGSLV 322
Cdd:COG4886 345 SLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-301 2.45e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 155 IKKINKNDFASLSDLKRIDLTSNliseideDAFRKLPQLRELVLRDNKIRQLPEL---PTTLTFIDISNNRLGRKGikqE 231
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP---E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 232 AFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNILEMHEdTFCNVKNLTYIR----------------KALED 293
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDlsgnqltdlpeplanlTNLET 232


                ....*...
gi 68800360 294 IRLDGNPI 301
Cdd:COG4886 233 LDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
169-223 1.43e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 1.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360   169 LKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPE-----LPtTLTFIDISNNRL 223
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsgLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
211-270 9.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 9.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68800360   211 TTLTFIDISNNRLgrKGIKQEAFKDMYDLHHLYLTDNNLDHIPL----PLPeNLRALHLQNNNI 270
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 153-301 1.37e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 153 NRIKKINknDFASLSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKI----------RQLPELPTTLTFIDISNNR 222
Cdd:cd21340  56 NQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekltfdpRSLAALSNSLRVLNISGNN 131

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68800360 223 LGrkgikqeafkDMYDLHHLYltdnnldhiplplpeNLRALHLQNNNILEMhEDTFCNVKNLTYirkaLEDIRLDGNPI 301
Cdd:cd21340 132 ID----------SLEPLAPLR---------------NLEQLDASNNQISDL-EELLDLLSSWPS----LRELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 167-270 3.66e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 3.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 167 SDLKRIDLTSNLISEID----EDAFRKLPQLRELVLRDNKIRQ------LPELP--TTLTFIDISNNRLGRKGIKQ--EA 232
Cdd:cd00116 137 PALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDagiralAEGLKanCNLEVLDLNNNGLTDEGASAlaET 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 68800360 233 FKDMYDLHHLYLTDNNLDHIP--------LPLPENLRALHLQNNNI 270
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 162-249 2.90e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 2.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 162 DFASLSDLKRIDLTSNLISEID----EDAFRKLPQLRELVLRDNKIR---------QLPELPTTLTFIDISNNRLGRKGI 228
Cdd:cd00116 188 GLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTdagaaalasALLSPNISLLTLSLSCNDITDDGA 267

                        90       100
                ....*....|....*....|...
gi 68800360 229 KQ--EAFKDMYDLHHLYLTDNNL 249
Cdd:cd00116 268 KDlaEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 172-270 9.16e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 9.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 172 IDLTSNLISE--IDE--DAFRKLPQLRELVLRDNKI--RQLPEL------PTTLTFIDISNNRLGRKGIKQ--EAFKDMY 237
Cdd:COG5238 185 VYLGCNQIGDegIEElaEALTQNTTVTTLWLKRNPIgdEGAEILaealkgNKSLTTLDLSNNQIGDEGVIAlaEALKNNT 264

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 68800360 238 DLHHLYLTDNNLDH-------IPLPLPENLRALHLQNNNI 270
Cdd:COG5238 265 TVETLYLSGNQIGAegaialaKALQGNTTLTSLDLSVNRI 304
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
191-275 3.49e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  191 PQLRELVLRDNKIRQLPE-LPTTLTFIDISNNRLGrkgIKQEAFKDMydLHHLYLTDNNLDHIPLPLPENLRALHLQNNN 269
Cdd:PRK15370 325 PGLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPPT--ITTLDVSRNALTNLPENLPAALQIMQASRNN 399


                 ....*.
gi 68800360  270 ILEMHE 275
Cdd:PRK15370 400 LVRLPE 405
LRRNT smart00013
Leucine rich repeat N-terminal domain;
121-145 4.37e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 4.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 68800360    121 CTCISTTVYCDDHELDAIPP-LPKNT 145
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 121-142 5.28e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 5.28e-04
                          10        20
                  ....*....|....*....|...
gi 68800360   121 CTCISTTVYCDDHELDAIPP-LP 142
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 166-272 7.33e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360 166 LSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKIrqLPELP---------TTLTFIDISNNRLGRKG--IKQEAFK 234
Cdd:cd00116  58 LSLNETGRIPRGLQSLLQ--GLTKGCGLQELDLSDNAL--GPDGCgvlesllrsSSLQELKLNNNGLGDRGlrLLAKGLK 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 68800360 235 DMY-DLHHLYLTDNNLDHIP-------LPLPENLRALHLQNNNILE 272
Cdd:cd00116 134 DLPpALEKLVLGRNRLEGAScealakaLRANRDLKELNLANNGIGD 179
LRR_8 pfam13855
Leucine rich repeat;
239-301 8.63e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 8.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68800360   239 LHHLYLTDNNLDHIP------LPlpeNLRALHLQNNNILEMHEDTFCNVKNLTYirkaledIRLDGNPI 301
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgafkgLS---NLKVLDLSNNLLTTLSPGAFSGLPSLRY-------LDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-301 1.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68800360 239 LHHLYLTDNNLDHIP-LPLPENLRALHLQNNNILEMhedtfCNVKNLtyirKALEDIRLDGNPI 301
Cdd:cd21340  26 LKVLYLYDNKITKIEnLEFLTNLTHLYLQNNQIEKI-----ENLENL----VNLKKLYLGGNRI 80
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 162-268 1.21e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360  162 DFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIR-QLP-ELPT--TLTFIDISNNRLgrKGIKQEAFKDMY 237
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPdELSSckKLVSLDLSHNQL--SGQIPASFSEMP 547

                         90       100       110
                 ....*....|....*....|....*....|....
gi 68800360  238 DLHHLYLTDNNLD-HIPLPLP--ENLRALHLQNN 268
Cdd:PLN00113 548 VLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHN 581
LRR_9 pfam14580
Leucine-rich repeat;
194-287 6.95e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.05  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68800360   194 RELVLRDNKIRQLPELPTTL---TFIDISNNRLgrkgIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPE---NLRALHLQN 267
Cdd:pfam14580  22 RELDLRGYKIPIIENLGATLdqfDTIDFSDNEI----RKLDGFPLLRRLKTLLLNNNRICRIGEGLGEalpNLTELILTN 97

                          90       100
                  ....*....|....*....|.
gi 68800360   268 NNILEMHE-DTFCNVKNLTYI 287
Cdd:pfam14580  98 NNLQELGDlDPLASLKKLTFL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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