NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|687678231|emb|CDZ21912|]
View 

YhaV toxic endonuclease, subunit of PrlF-YhaV antitoxin-toxin complex [Escherichia coli]

Protein Classification

type II toxin-antitoxin system YhaV family toxin( domain architecture ID 10569416)

type II toxin-antitoxin (TA) system YhaV family toxin similar to Escherichia coli YhaV, which acts as a transcription factor and is the toxin component of the YhaV/PrlF TA system; YhaV causes reversible bacteriostasis that is counteracted by PrlF

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 12-143 1.16e-70

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


:

Pssm-ID: 431989  Cd Length: 138  Bit Score: 209.05  E-value: 1.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 687678231   12 LYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGsGKNKDWSRVKFGAg 91
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKDPEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLG-PKYKHWFRAKFGQ- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 687678231   92 RYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADW 143
Cdd:pfam11663  79 RYRLFFRYFSESKIIVYAWVNDENTLRKYGSKTDAYAVFTKMLERGNPPDDW 130
 
Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 12-143 1.16e-70

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


Pssm-ID: 431989  Cd Length: 138  Bit Score: 209.05  E-value: 1.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 687678231   12 LYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGsGKNKDWSRVKFGAg 91
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKDPEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLG-PKYKHWFRAKFGQ- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 687678231   92 RYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADW 143
Cdd:pfam11663  79 RYRLFFRYFSESKIIVYAWVNDENTLRKYGSKTDAYAVFTKMLERGNPPDDW 130
 
Name Accession Description Interval E-value
Toxin_YhaV pfam11663
Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible ...
 12-143 1.16e-70

Toxin with endonuclease activity, of toxin-antitoxin system; YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.


Pssm-ID: 431989  Cd Length: 138  Bit Score: 209.05  E-value: 1.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 687678231   12 LYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGsGKNKDWSRVKFGAg 91
Cdd:pfam11663   1 LFAHPLFLEQLEELIAAVERLKAKDPEDYVKHPAVKLLAAINKLIFDKIPQDPTASEYRQGGTLG-PKYKHWFRAKFGQ- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 687678231   92 RYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADW 143
Cdd:pfam11663  79 RYRLFFRYFSESKIIVYAWVNDENTLRKYGSKTDAYAVFTKMLERGNPPDDW 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH