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Conserved domains on  [gi|68643138|emb|CAI33438|]
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putative glycosyl transferase [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-157 3.75e-61

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


:

Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 185.90  E-value: 3.75e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138   1 MIFVTVGTHEQQFNRLIKEIDELKAEGVITSDVFIQVGFSDYQPRFCRWERFLSYDEMNNLMEEADIVITHGGPATFMNV 80
Cdd:COG5017   1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  81 IANGKRPVVVPRRKKFGEHVNDHQLDFCNRIVQEGYdLVVIEDIKKIREYL-------NPSSSIAVKSNNECFVQHFSNL 153
Cdd:COG5017  81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLGG-IIVVEDPADLEAALdealalkSPEPFSVPSPARGALVDFLRAF 159


                ....
gi 68643138 154 IAEL 157
Cdd:COG5017 160 ITEL 163
 
Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-157 3.75e-61

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 185.90  E-value: 3.75e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138   1 MIFVTVGTHEQQFNRLIKEIDELKAEGVITSDVFIQVGFSDYQPRFCRWERFLSYDEMNNLMEEADIVITHGGPATFMNV 80
Cdd:COG5017   1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  81 IANGKRPVVVPRRKKFGEHVNDHQLDFCNRIVQEGYdLVVIEDIKKIREYL-------NPSSSIAVKSNNECFVQHFSNL 153
Cdd:COG5017  81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLGG-IIVVEDPADLEAALdealalkSPEPFSVPSPARGALVDFLRAF 159


                ....
gi 68643138 154 IAEL 157
Cdd:COG5017 160 ITEL 163
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
2-132 1.47e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 120.32  E-value: 1.47e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138    2 IFVTVGTheQQFNRLIKEIDELkAEGVITSDVFIQVGFSDYQPRFCRWERFLsyDEMNNLMEEADIVITHGGPATFMNVI 81
Cdd:NF041548   1 IFVTVGT--TRFDSLIKAIDEL-IEGLIDYEVTFQIGDGKYIPKNGEYFDFL--EEIDEYYKKADLIITHAGAGTIYSLL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 68643138   82 ANGKRPVVVPRRkkfgEHVNDHQLDFCNRIVQEGYDLVV--IEDI-KKIREYLN 132
Cdd:NF041548  76 ELGKKVIVVPNL----ERVDDHQLDLAEYVEENGYALVCydLDELeDAIKEAEN 125
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 1-158 5.78e-23

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 88.92  E-value: 5.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138     1 MIFVTVGTHEQQ-FNRLIKEIDELKAEGVITSdVFIQVGFSDYQPRFCRWERF------LSY-DEMNNLMEEADIVITHG 72
Cdd:pfam04101   1 TILVTGGSQGARaLNELVLSVLPLLELKGELQ-VLHQTGKGDLEEVKIDYAELginyevFPFiDNMAEYIKAADLVISRA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138    73 GPATFMNVIANGKRPVVVPRRKKFGEHVNDHQLDFcnriVQEGYDLVVIED-------IKKIREYLNPSSSIAvkSNNEC 145
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKEL----VKAGAALVILQKeltpeklIEALLKLLLNPLRLA--EMAKA 153

                         170
                  ....*....|...
gi 68643138   146 FVQHFSNLIAELV 158
Cdd:pfam04101 154 SKASGFKDAAKRL 166
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
 56-143 1.58e-03

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 37.68  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  56 DEMNNLMEEADIVITHGGPATFMNVIANGKrPVVVPRRKKFGEHVNDhqldfcNRIVQEGYDLVV--IEDIKKIREYL-N 132
Cdd:cd17507 259 DDMNELMAASDLVITKPGGLTISEALARGL-PVIIYDPIPGQEEENA------DFLENNGAGIIArdPEELLEIVARLiD 331

                        90
                ....*....|.
gi 68643138 133 PSSSIAVKSNN 143
Cdd:cd17507 332 PPSLLRMMSEA 342
 
Name Accession Description Interval E-value
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
1-157 3.75e-61

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 185.90  E-value: 3.75e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138   1 MIFVTVGTHEQQFNRLIKEIDELKAEGVITSDVFIQVGFSDYQPRFCRWERFLSYDEMNNLMEEADIVITHGGPATFMNV 80
Cdd:COG5017   1 MIFVTVGTHQLPFDRLVRWVDELAAEGIIDEEVFVQTGHTTYVPRNAEAVPFLPPDEFQKLIAQARLVISHAGMGSILTA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  81 IANGKRPVVVPRRKKFGEHVNDHQLDFCNRIVQEGYdLVVIEDIKKIREYL-------NPSSSIAVKSNNECFVQHFSNL 153
Cdd:COG5017  81 LKLGKPFILVPRLARYGEHVDDHQLETARALEKLGG-IIVVEDPADLEAALdealalkSPEPFSVPSPARGALVDFLRAF 159


                ....
gi 68643138 154 IAEL 157
Cdd:COG5017 160 ITEL 163
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
2-132 1.47e-35

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 120.32  E-value: 1.47e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138    2 IFVTVGTheQQFNRLIKEIDELkAEGVITSDVFIQVGFSDYQPRFCRWERFLsyDEMNNLMEEADIVITHGGPATFMNVI 81
Cdd:NF041548   1 IFVTVGT--TRFDSLIKAIDEL-IEGLIDYEVTFQIGDGKYIPKNGEYFDFL--EEIDEYYKKADLIITHAGAGTIYSLL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 68643138   82 ANGKRPVVVPRRkkfgEHVNDHQLDFCNRIVQEGYDLVV--IEDI-KKIREYLN 132
Cdd:NF041548  76 ELGKKVIVVPNL----ERVDDHQLDLAEYVEENGYALVCydLDELeDAIKEAEN 125
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 1-158 5.78e-23

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 88.92  E-value: 5.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138     1 MIFVTVGTHEQQ-FNRLIKEIDELKAEGVITSdVFIQVGFSDYQPRFCRWERF------LSY-DEMNNLMEEADIVITHG 72
Cdd:pfam04101   1 TILVTGGSQGARaLNELVLSVLPLLELKGELQ-VLHQTGKGDLEEVKIDYAELginyevFPFiDNMAEYIKAADLVISRA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138    73 GPATFMNVIANGKRPVVVPRRKKFGEHVNDHQLDFcnriVQEGYDLVVIED-------IKKIREYLNPSSSIAvkSNNEC 145
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKEL----VKAGAALVILQKeltpeklIEALLKLLLNPLRLA--EMAKA 153

                         170
                  ....*....|...
gi 68643138   146 FVQHFSNLIAELV 158
Cdd:pfam04101 154 SKASGFKDAAKRL 166
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
2-116 1.69e-07

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 49.08  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138   2 IFVTVGTHEQQFNRLIKEIDE-LKAEGVitsDVFIQVG------FSDYQPRFcRWERFLSYDEmnnLMEEADIVITHGGP 74
Cdd:COG1819 123 VYVTLGTSANDRADLLRAVLEaLADLGV---RVVVTTGgldpaeLGPLPDNV-RVVDYVPQDA---LLPRADAVVHHGGA 195

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 68643138  75 ATFMNVIANGKRPVVVPrrkkfgeHVNDhQLDFCNRIVQEGY 116
Cdd:COG1819 196 GTTAEALRAGVPQVVVP-------FGGD-QPLNAARVERLGA 229
COG4671 COG4671
Predicted glycosyl transferase [General function prediction only];
48-92 3.46e-05

Predicted glycosyl transferase [General function prediction only];


Pssm-ID: 443708 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 3.46e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 68643138  48 RWERFLsyDEMNNLMEEADIVITHGGPATFMNVIANGKRPVVVPR 92
Cdd:COG4671 277 TVERFT--PDFEALLAAADLSVSMGGYNTVCEILSTGKPALIVPR 319
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
 56-143 1.58e-03

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 37.68  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  56 DEMNNLMEEADIVITHGGPATFMNVIANGKrPVVVPRRKKFGEHVNDhqldfcNRIVQEGYDLVV--IEDIKKIREYL-N 132
Cdd:cd17507 259 DDMNELMAASDLVITKPGGLTISEALARGL-PVIIYDPIPGQEEENA------DFLENNGAGIIArdPEELLEIVARLiD 331

                        90
                ....*....|.
gi 68643138 133 PSSSIAVKSNN 143
Cdd:cd17507 332 PPSLLRMMSEA 342
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 11-104 2.07e-03

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 37.19  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68643138  11 QQFNRLIKE-IDELKAEGVItsdVFIQVGFSDYQ------PRFCRWERFLSY-DEMNNLMEEADIVITHGGPATFMNVIA 82
Cdd:cd03785 194 RAINRAVPKaLPKLLERGIQ---VIHQTGKGDYDevkklyEDLGINVKVFPFiDDMAAAYAAADLVISRAGASTIAELTA 270

                        90       100
                ....*....|....*....|..
gi 68643138  83 NGKRPVVVPrrkkFGEHVNDHQ 104
Cdd:cd03785 271 AGKPAILIP----YPYAADDHQ 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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