|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
33-1052 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 761.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:COG0841 31 RLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITSTSSEGSSSITVEFELGTDIDEALVDVQN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 113 EIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQ 190
Cdd:COG0841 111 AVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 191 NELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamsd 270
Cdd:COG0841 191 DKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFENIVI------------------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 271 vnqaspqqnsKASAPNNIsgmptaKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFvde 349
Cdd:COG0841 246 ----------RTNDGSVV------RLGDVARVEDGaEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEEL--- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 350 NKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNIL 425
Cdd:COG0841 307 QASLpegvELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNIL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 426 TLGALTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFA 505
Cdd:COG0841 387 TLFALVLAIGIVVDDAIVVVENIERHM---EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 506 LAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQE----GLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATiVF 581
Cdd:COG0841 464 LTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRafnrGFDRLTRGYGRLLRWALRHRKLTLLVALALLALS-VL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 582 GGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPvdpTGSTNSMAIMVEYDN 661
Cdd:COG0841 543 LFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGG---GSGSNSGTIFVTLKP 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 662 ----DTPNFDVeADKIIKHVDGFkhPG---EWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKS 734
Cdd:COG0841 620 wderDRSADEI-IARLREKLAKI--PGarvFVFQPPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRS 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 735 DLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGT 814
Cdd:COG0841 697 DLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEM 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 815 IKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTD-KDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFA 893
Cdd:COG0841 777 VPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPgVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLA 856
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 894 MLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQG 973
Cdd:COG0841 857 FLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEG 936
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686251466 974 MEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRF 1052
Cdd:COG0841 937 MSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
33-1042 |
3.48e-176 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 542.27 E-value: 3.48e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:pfam00873 29 SLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSSITLTFELGTDIDIARQDVQN 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 113 EIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTK--VLNEQLIPKLQTVDGVQNAQLNGQTNREITLKF 188
Cdd:pfam00873 109 RLQLATPLlpEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLrdYADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 189 KQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsam 268
Cdd:pfam00873 189 DPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIV----------------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 269 sdvnqaspqqnskasapNNISGMPTaKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRK---ID 344
Cdd:pfam00873 246 -----------------KNQDGSPV-RLRDVATVELGsELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKlaeLK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 345 TFVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNI 424
Cdd:pfam00873 308 PTFPQGVEIVVV--YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINT 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 425 LTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPF 504
Cdd:pfam00873 386 LTLGGLVLAIGLVVDDAIVVVENIERVL--EENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQF 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 505 ALAIAFSLLASLLVSITLVPALAATLfkkgVKRRNKQHQEGLGVVSTT--------YKKVLHWSLNHKWIVIILSTLILV 576
Cdd:pfam00873 464 AITIVLAILLSVLVALTLTPALCATL----LKPRREPKHGGFFRWFNRmfdrltrgYAKLLAKVLRHTAVVLLVALLLVV 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 577 ATiVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQySVGGSSPVDPTGSTNS--MA 654
Cdd:pfam00873 540 GS-VWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVF-AVTGFAFSGDNNGPNSgdAF 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 655 IMVEYDNDTPNFDVEADKIIKHVDG--FKHPGEWKN-------QDLGTGAG-NKSVEVTVKGPSMDAIKSTVKDIEQKMK 724
Cdd:pfam00873 618 ISLKPWKERPGPEKSVQALIERLRKalKQIPGANVFlfqpiqlRGLGTISGfRSDLQVKIFGDDLDALDEARNQILAALA 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 725 QVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNN 804
Cdd:pfam00873 698 QLPGLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQ 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 805 ITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDKDVGGTTRQVMSKI-NNLDKPNNVKVNIGGASDDI 883
Cdd:pfam00873 778 LYVRNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIaKQVKLPPGYGYTWTGQFEQE 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 884 NNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLI 963
Cdd:pfam00873 858 QLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMV 937
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 964 DrVIN--NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLF--GQDSSILisKGLAATVIGGLISSTLLTLVVVP 1039
Cdd:pfam00873 938 E-FANelREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALstGAGSELQ--QPLGIVVFGGLVTSTVLTLLVVP 1014
|
...
gi 686251466 1040 VIY 1042
Cdd:pfam00873 1015 VFY 1017
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1045 |
6.42e-155 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 486.46 E-value: 6.42e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 1 MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVK 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 81 NVKTQSIQNASIVTVEYENNTD-----------MDKAEEQLKKEIdkikfkdevgQPELrrnSMDAFP---VLAYSFSNK 146
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDiywarqlvlerLQQVREQLPAGV----------TPEL---GPISTGlgeIYQYTLESD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 147 EN--DLKKVTKVLNEQLIPKLQTVDGVqnAQLN--GQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFG 222
Cdd:COG3696 148 PGkySLMELRTLQDWVIRPQLRSVPGV--AEVNsfGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 223 DKDKSIVVDGQYQSVDAFKNIniPLTlaggqgqsqsqsdnkqnsamsdvnqaspqqnskasapnNISGMPTaKLGDLADI 302
Cdd:COG3696 226 GQEYLVRGIGLIRSLEDIENI--VVK--------------------------------------TRNGTPV-LLRDVAEV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 303 TVG-DVRTSISKTNGK-DAVNLQITKAQDANTVQVAKDVQRKIDTfVDEN--KDFNVTKTMDTAKPVEKSLYTMVEKASL 378
Cdd:COG3696 265 RIGpAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAE-LKPSlpEGVKIVPFYDRSDLIDRAIHTVTKNLLE 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 379 GTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQ 458
Cdd:COG3696 344 GALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRRLEENRAA 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 459 LKGEN---LIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGV 535
Cdd:COG3696 424 GTPRErleVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRGKV 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 536 KrrnkqHQEG--LGVVSTTYKKVLHWSLNHKWIVIILSTLILVATiVFGGPRLGTSFISA---GDdkfLAITYTPKPGET 610
Cdd:COG3696 504 P-----EKENplVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLA-LALFPRLGSEFLPEldeGD---LLVMATLPPGIS 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 611 EQAVLNHAKDVEKYLKQKKHVKTIQYSVG-GSSPVDPTGSTNS--MAIMVEYDNDTPNFDVEA--DKIIKHVDGFkhPG- 684
Cdd:COG3696 575 LEESVELGQQVERILKSFPEVESVVSRTGrAEDATDPMGVNMSetFVILKPRSEWRSGRTKEEliAEMREALEQI--PGv 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 685 --EWkNQ-------DLGTGAgnKSvEVTVK--GPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAA 753
Cdd:COG3696 653 nfNF-SQpiqmrvdELLSGV--RA-DVAVKifGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAA 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 754 ENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLT 833
Cdd:COG3696 729 RYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQIS 808
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 834 QEQGDYATTVSAKVTDKDVGGTTRQVMSKIN-NLDKPNNVKVNIGGASDDINNAMTQLA----------FAMLAAiiivy 902
Cdd:COG3696 809 RENGRRRIVVQANVRGRDLGSFVAEAQAKVAeQVKLPPGYYIEWGGQFENLQRATARLAivvplallliFLLLYL----- 883
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 903 lilviTFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIE 982
Cdd:COG3696 884 -----AFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIE 958
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686251466 983 AGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEIL 1045
Cdd:COG3696 959 GALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLLF 1021
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
33-1045 |
7.35e-144 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 456.79 E-value: 7.35e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:NF033617 28 KLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTITLQFRLGTDLDVALSEVQA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 113 EIDKIKFK--DEVGQPELRR--NSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKF 188
Cdd:NF033617 108 AINAAQSLlpSEAPDPPVYRkaNSADT-PIMYIGLTSEEMPRGQLTDYAERVLAPKLSQINGVGSVDVSGGQRPAMRVWL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 189 KQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnKQNSam 268
Cdd:NF033617 187 DPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVI-----------------KYAD-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 269 sdvnqaspqqnskasapnniSGMPTaKLGDLADITVG--DVRtSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTf 346
Cdd:NF033617 248 --------------------NGAPV-RLGDVATVELGaeNVR-NRAWANGVPAVVLGINRQPGANPIEVADEIRALLPE- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 347 VDEN--KDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNI 424
Cdd:NF033617 305 LQETlpKNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 425 LTLGALTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPF 504
Cdd:NF033617 385 LTLMALVLAIGLVVDDAIVVVENIHRHI---EEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREF 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 505 ALAIAFSLLASLLVSITLVPALAATLFKKGVK--RRNKQHQEGLGVVSTTYKKVLHWSLNHKWIViilstlILVATIVFG 582
Cdd:NF033617 462 AVTLAGAVIISGIVALTLTPMMCSRLLKANEKpgRFARAVDRFFDGLTARYGRGLKWVLKHRPLT------LVVALATLA 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 583 GPRLGTSFISAG----DDKFLAITYTPKP-GETEQAVLNHAKDVEK-YLKQKKHVKTIQYSVGGSSPVDPTGSTnsMAIM 656
Cdd:NF033617 536 LLPLLYVFIPKElapsEDRGVIFGMIQAPqSISLDYMSAKMRDVEKiLSSDPEVQSLTSFNGVGGNPGDNTGFG--IINL 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 657 VEYDNDtpnfDVEADKIIKHVDGF--KHPGE----WKNQDL--GTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKG 728
Cdd:NF033617 614 KPWDER----DVSAQEIIDRLRPKlaKVPGMdlflFPLQDLpgGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQ 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 729 LANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLK 808
Cdd:NF033617 690 FADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVR 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 809 KPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMT 888
Cdd:NF033617 770 SNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGS 849
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 889 QLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDrVIN 968
Cdd:NF033617 850 SLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVE-FAN 928
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686251466 969 NEQ--QGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEIL 1045
Cdd:NF033617 929 ELQrhQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLL 1007
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1055 |
3.63e-94 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 323.25 E-value: 3.63e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 1 MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVK 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 81 NVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVG-QPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNE 159
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGvSPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 160 Q---------LIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVV 230
Cdd:TIGR00914 161 TdlrtiqdwiIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 231 DGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamsdvnqaspqqnskasapNNISGMPTaKLGDLADITVG-DVRT 309
Cdd:TIGR00914 241 PGQVQSMDDIRNIVI----------------------------------------ATGEGVPI-RIRDVARVQIGkELRT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 310 SISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFvdeNKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAII 385
Cdd:TIGR00914 280 GAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETI---NKTLpegvEIVTTYDRSQLVDAAIATVKKNLLEGALLVIV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 386 VILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALtvAIGRVIDDSIVVVENIYRRLTDSEEQLkGENL- 464
Cdd:TIGR00914 357 ILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLt 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 465 -------IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKR 537
Cdd:TIGR00914 434 lkerlheVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVAE 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 538 RNKQHqegLGVVSTTYKKVLHWSLNHKwIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNH 617
Cdd:TIGR00914 514 KENRL---MRVLKRRYEPLLERVLAWP-AVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAM 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 618 AKDVEKYLKQKKHVKTIQYSVG----GSSPVDPTGSTNSmaIMVEYDNDTPN-FDVEADKIIKHVDG----------FKH 682
Cdd:TIGR00914 590 QQTLEKLIKSFPEVARVFAKTGtaeiATDPMPPNASDTY--IILKPESQWPEgKKTKEDLIEEIQEAtvripgnnyeFTQ 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 683 PGEWKNQDLGTGAgNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQL 762
Cdd:TIGR00914 668 PIQMRFNELISGV-RSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDV 746
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 763 AMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGG-----TIKLGDIATLVKTTTPSKLTQEQG 837
Cdd:TIGR00914 747 QDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENG 826
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 838 DYATTVSAKVTDKDVGGTTRQVMSKINNLDK-PNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPF 916
Cdd:TIGR00914 827 KRRVVVSANVRGRDLGSFVDDAKKAIAEQVKlPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDAL 906
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 917 TILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAI 996
Cdd:TIGR00914 907 LVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTAL 986
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*....
gi 686251466 997 ATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEIlfTLKKRFTKR 1055
Cdd:TIGR00914 987 VASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRL--VHRRRHKGR 1043
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
15-1042 |
1.37e-81 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 287.40 E-value: 1.37e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 15 AIFLMVVLVvlggvYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASI-V 93
Cdd:TIGR00915 16 AIIIMLAGT-----LSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSDGSMtI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 94 TVEYENNTDMDKAEEQLKKEIDKI--KFKDEVGQPELR--RNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVD 169
Cdd:TIGR00915 91 TLTFEQGTDPDIAQVQVQNKLQLAtpLLPQEVQRQGVRveKASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDPLSRLE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 170 GVQNAQLNGqTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDK--------DKSIVVDGQYQSVDAFK 241
Cdd:TIGR00915 171 GVGDVQLFG-SQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAG--QLGGLpavpgqqlNATIIAQTRLQTPEQFE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 242 NINIpltlaggqgqsqsqsdnKQNSAMSDVnqaspqqnskasapnnisgmptaKLGDLADITVG-DVRTSISKTNGKDAV 320
Cdd:TIGR00915 248 NILL-----------------KVNTDGSQV-----------------------RLKDVARVELGgENYSISARFNGKPAS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 321 NLQITKAQDANTVQVAKDVQRKIDtfvDENKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRT 396
Cdd:TIGR00915 288 GLAIKLATGANALDTAKAVKAELA---VLEPFFpqgmKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 397 TAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPI 476
Cdd:TIGR00915 365 TLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVM--AEEGLPPKEATRKSMGQIQGAL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 477 MSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG--------LGV 548
Cdd:TIGR00915 443 VGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIEKGEHHEKKGGffgwfnrmFDS 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 549 VSTTYKKVLHWSLNHKWIVIILSTLILVATiVFGGPRLGTSFISAGDDK-FLAITYTPkPGETEQAVLNHAKDVEKYL-- 625
Cdd:TIGR00915 523 STHGYENGVGKILRRRGRYLLVYVLLVGGM-VFLFVRLPTSFLPDEDQGvFMTIVQLP-AGATAERTQAVLAQVTKYLla 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 626 KQKKHVKTIqYSVGGSSPvdpTGSTNSMAIMVEY-----DNDTPNFDVEAdkIIKHVdgFKHPGEWKN-----------Q 689
Cdd:TIGR00915 601 KEKANVESV-FTVNGFSF---AGRGQNMGMAFIRlkdweERTGKENSVFA--IAGRA--TGHFMQIKDamviafvppaiL 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 690 DLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNEN 769
Cdd:TIGR00915 673 ELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTA 752
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 770 LPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTd 849
Cdd:TIGR00915 753 WGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAA- 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 850 kdVGGTTRQVMSKINNLDK--PNNVKVNIGGASDDINNAMTQ----------LAFAMLAAIiivylilvitFKGGLAPFT 917
Cdd:TIGR00915 832 --PGVSTGQAMAAMEAIAQklPPGFGFSWTGMSYEERLSGSQapalyalsllVVFLCLAAL----------YESWSIPVS 899
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 918 ILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIA 997
Cdd:TIGR00915 900 VMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLA 979
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*
gi 686251466 998 TIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIY 1042
Cdd:TIGR00915 980 FILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFY 1024
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
34-1055 |
1.01e-74 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 267.75 E-value: 1.01e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 34 LKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKE 113
Cdd:PRK10503 41 LPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 114 IDKIK--FKDEVGQPEL--RRNSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFK 189
Cdd:PRK10503 121 INAATnlLPSDLPNPPVysKVNPADP-PIMTLAVTSTAMPMTQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 190 QNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLtlaggqgqsqsqsdnkqnsams 269
Cdd:PRK10503 200 AQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLIIAY---------------------- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 270 dvnqaspqqnsKASAPnnisgmptAKLGDLADITVGDVRTSISK-TNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVD 348
Cdd:PRK10503 258 -----------QNGAP--------IRLGDVATVEQGAENSWLGAwANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 349 E-NKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTL 427
Cdd:PRK10503 319 SlPKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 428 GALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGEnliISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALA 507
Cdd:PRK10503 399 MALTIATGFVVDDAIVVIENISRYIEKGEKPLAAA---LKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVT 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 508 IAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG----LGVVSTTYKKVLHWSLNHKWIV--IILSTLILVATIVF 581
Cdd:PRK10503 476 LAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRAsermFDRVIAAYGRGLAKVLNHPWLTlsVALSTLLLTVLLWI 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 582 GGPRlgtSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGgsspVDPTGST-NSMAIMVeyd 660
Cdd:PRK10503 556 FIPK---GFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVG----VDGTNPSlNSARLQI--- 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 661 NDTPnFDVEADKIIKHVDGFKH-----PGE----WKNQDL--GTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGL 729
Cdd:PRK10503 626 NLKP-LDERDDRVQKVIARLQTavakvPGVdlylQPTQDLtiDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQL 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 730 ANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKK 809
Cdd:PRK10503 705 SDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTS 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 810 PTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDK-DVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMT 888
Cdd:PRK10503 785 SDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGySLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 889 QLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVIN 968
Cdd:PRK10503 865 STVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALA 944
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 969 NE-QQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYeILFT 1047
Cdd:PRK10503 945 AErEQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIY-LLFD 1023
|
....*...
gi 686251466 1048 LKKRFTKR 1055
Cdd:PRK10503 1024 RLALYTKS 1031
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
39-1055 |
2.50e-72 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 260.43 E-value: 2.50e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 39 LPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIK 118
Cdd:PRK10614 37 LPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 119 FKDEVG---QPELRR-NSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELE 194
Cdd:PRK10614 117 SLLPSGmpsRPTYRKaNPSDA-PIMILTLTSDTYSQGQLYDFASTQLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 195 KYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamsDVNQA 274
Cdd:PRK10614 196 NQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLII------------------------HYNNG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 275 SPqqnskasapnnisgmptAKLGDLADIT--VGDVRTSiSKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTF---VDE 349
Cdd:PRK10614 252 AA-----------------VRLGDVATVTdsVQDVRNA-GMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELretIPA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 350 NKDFNVTKtmDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGA 429
Cdd:PRK10614 314 AIDLQIAQ--DRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 430 LTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIA 509
Cdd:PRK10614 392 LTIATGFVVDDAIVVLENISRHL---EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 510 FSLLASLLVSITLVPALAATLFkKGVKRRNKQHQEGLG----VVSTTYKKVLHWSLNH-KWI-VIILSTLILVATIVFGG 583
Cdd:PRK10614 469 VAIGISLLVSLTLTPMMCAWLL-KSSKPREQKRLRGFGrmlvALQQGYGRSLKWVLNHtRWVgVVLLGTIALNVWLYISI 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 584 PRlgtSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSspvdptgSTNSMAIMVEYdNDT 663
Cdd:PRK10614 548 PK---TFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGS-------RVNSGMMFITL-KPL 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 664 PNFDVEADKIIKHVDG--FKHPGE----WKNQDLGTGA--GNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSD 735
Cdd:PRK10614 617 SERSETAQQVIDRLRVklAKEPGAnlflMAVQDIRVGGrqSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSD 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 736 LSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKE--NGKTVDVKVKQNKQTDWSedKLNNITLKKPTGG 813
Cdd:PRK10614 697 QQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQplNQYKVVMEVDPRYTQDIS--ALEKMFVINNEGK 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 814 TIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDkdvGGTTRQVMSKIN----NLDKPNNVKVNIGGASDDINNAMTQ 889
Cdd:PRK10614 775 AIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPT---GKSLSDASAAIEramtQLGVPSTVRGSFAGTAQVFQETMNS 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 890 LAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINN 969
Cdd:PRK10614 852 QLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEA 931
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 970 EQQG-MEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTL 1048
Cdd:PRK10614 932 QRNGnLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL 1011
|
....*..
gi 686251466 1049 KKRFTKR 1055
Cdd:PRK10614 1012 RLRFSRK 1018
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
30-1045 |
6.92e-69 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 250.14 E-value: 6.92e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 30 ASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQ 109
Cdd:PRK09579 28 AWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSIISIYARIGADSDRLFTE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 110 LKKEIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLK 187
Cdd:PRK09579 108 LLAKANEVKNQlpQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPKLATLPGMAEAEILGNQVFAMRLW 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 188 FKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFkninipltlaggqgqsqsqsdnkqnsa 267
Cdd:PRK09579 188 LDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAF--------------------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 268 msdvnqaspqqnskASAPNNISGMPTAKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTF 346
Cdd:PRK09579 241 --------------AAIPVKTSGDSRVLLGDVARVEMGaENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPEL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 347 VDE-NKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNIL 425
Cdd:PRK09579 307 ESQlPPNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 426 TLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGEnliISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFA 505
Cdd:PRK09579 387 TLLAMVLAIGLVVDDAIVVVENIHRHIEEGKSPFDAA---LEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 506 LAIAFSLLASLLVSITLVPALAATLFK-----KGVKRRNKQHQEGLGVvstTYKKVLHWSLNHKWIVIILSTLILVATIV 580
Cdd:PRK09579 464 LTLAGAVIISGIVALTLSPMMCALLLRheenpSGLAHRLDRLFERLKQ---RYQRALHGTLNTRPVVLVFAVIVLALIPV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 581 FggPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKD-VEKYLK---------QKKHVKTIQYSVGGS--SPVDPTG 648
Cdd:PRK09579 541 L--LKFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDeFTPIFKsfpeyyssfQINGFNGVQSGIGGFllKPWNERE 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 649 STNsMAIMveydndtPNFDVEADKIIK-HVDGFKHPGEwknqdLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVK 727
Cdd:PRK09579 619 RTQ-MELL-------PLVQAKLEEIPGlQIFGFNLPSL-----PGTGEGLPFQFVINTANDYESLLQVAQRVKQRAQESG 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 728 GLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITL 807
Cdd:PRK09579 686 KFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYV 765
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 808 KKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSA--KVTDKDVGGTTRQVMSKinnlDKPNNVKVNIGGASDDINN 885
Cdd:PRK09579 766 KNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAIISGfpIVSMGEAIETVQQIARE----EAPEGFAFDYAGASRQYVQ 841
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 886 AMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDR 965
Cdd:PRK09579 842 EGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEF 921
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 966 VIN-NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEI 1044
Cdd:PRK09579 922 ANQlRHEQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTL 1001
|
.
gi 686251466 1045 L 1045
Cdd:PRK09579 1002 L 1002
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
30-1051 |
1.35e-62 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 231.64 E-value: 1.35e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 30 ASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASI-VTVEYENNTDMDKAEE 108
Cdd:PRK10555 26 AIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQAsVTLSFKAGTDPDEAVQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 109 QLKKEIDKI--KFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKK--VTKVLNEQLIPKLQTVDGVQNAQLNG-QTNRE 183
Cdd:PRK10555 106 QVQNQLQSAmrKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKqdIADYVASNIQDPLSRVNGVGDIDAYGsQYSMR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 184 ITLKfkQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDKDKsivVDGQyqSVDAFKNinipltlaggqgqsqsqsdnk 263
Cdd:PRK10555 186 IWLD--PAKLNSFQMTTKDVTDAIESQNAQIAVG--QLGGTPS---VDKQ--ALNATIN--------------------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 264 qnsAMSDVNqaSPQQNSKASAPNNISGmPTAKLGDLADITVGDVR-TSISKTNGKDAVNLQITKAQDANTVQVAKDVQRK 342
Cdd:PRK10555 236 ---AQSLLQ--TPEQFRDITLRVNQDG-SEVTLGDVATVELGAEKyDYLSRFNGKPASGLGVKLASGANEMATAKLVLNR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 343 IDT---FVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSD 419
Cdd:PRK10555 310 LDElaqYFPHGLEYKVA--YETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFG 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 420 VSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGE 499
Cdd:PRK10555 388 YSINTLTMFAMVLAIGLLVDDAIVVVENVERIM--SEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGA 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 500 MFRPFALAIAFSLLASLLVSITLVPALAATLFK---KG---------------VKRRNKQHQEGLGvvsttykKVLHWSL 561
Cdd:PRK10555 466 IYRQFSITIVSAMVLSVLVAMILTPALCATLLKplkKGehhgqkgffgwfnrmFNRNAERYEKGVA-------KILHRSL 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 562 nhKWIVIILstlILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYL--KQKKHVKTIQYSVG 639
Cdd:PRK10555 539 --RWILIYV---LLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYftHEKDNVMSVFATVG 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 640 GSspvdPTGSTNSMAIMV----EYDNDTPNFDVEADKIIKHVDGFKHPGEWKN--------QDLGTGAGNKSVEVTVKGP 707
Cdd:PRK10555 614 SG----PGGNGQNVARMFirlkDWDERDSKTGTSFAIIERATKAFNKIKEARViassppaiSGLGSSAGFDMELQDHAGA 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 708 SMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDV 787
Cdd:PRK10555 690 GHDALMAARNQLLALAAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKV 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 788 KVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDKDVGGTTRQVMSKINNlD 867
Cdd:PRK10555 770 YVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVK-Q 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 868 KPNNVKVNIGGAS--DDINNAMTQLAFAM--------LAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIALLITG 937
Cdd:PRK10555 849 LPNGFGLEWTAMSyqERLSGAQAPALYAIsllvvflcLAAL----------YESWSVPFSVMLVVPLGVIGALLATWMRG 918
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 938 ETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISK 1017
Cdd:PRK10555 919 LENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQH 998
|
1050 1060 1070
....*....|....*....|....*....|....*..
gi 686251466 1018 GLAATVIGGLISSTLLTLVVVPVIYEIL---FTLKKR 1051
Cdd:PRK10555 999 AVGTGVMGGMISATILAIFFVPLFFVLVrrrFPLKPR 1035
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
40-1055 |
1.88e-55 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 209.71 E-value: 1.88e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 40 PNVQNPVISVTTTMPGATPQSTQDEISSKID---NQVRSLAYVKnvKTQSIQNASIvTVEYENNTDMDKAEEQLKKEIDK 116
Cdd:PRK09577 36 PDIAPPVVSIYATYPGASAQVVEESVTALIEremNGAPGLLYTS--ATSSAGQASL-SLTFKQGVNADLAAVEVQNRLKT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 117 IkfkdEVGQPE-LRRN------SMDAFPvLAYSFSNKENDLKKVT--KVLNEQLIPKLQTVDGVQNAQLNGQtnrEITLK 187
Cdd:PRK09577 113 V----EARLPEpVRRDgiqvekAADNIQ-LIVSLTSDDGRLTGVElgEYASANVLQALRRVEGVGKVQFWGA---EYAMR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 188 FKQN--ELEKYGLTADDVENYLKT-ATRTTplglfqFGDKDKSIVVDgqyqsvdafkniNIPLTLaggqgqsqsqsdnkq 264
Cdd:PRK09577 185 IWPDpvKLAALGLTASDIASAVRAhNARVT------IGDIGRSAVPD------------SAPIAA--------------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 265 nSAMSDVNQASPQQNSKASAPNNISGmPTAKLGDLADITVGDVRTS-ISKTNGKDAVNLQITKAQDANTVQVAKDVQRKI 343
Cdd:PRK09577 232 -TVFADAPLKTPEDFGAIALRARADG-SALYLRDVARIEFGGNDYNyPSYVNGKTATGMGIKLAPGSNAVATEKRVRATM 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 344 D---TFVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDV 420
Cdd:PRK09577 310 DelsRYFPPGVKYQIP--YETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGF 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 421 SLNILTLGALTVAIGRVIDDSIVVVENIYRRLTdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEM 500
Cdd:PRK09577 388 SINVLTMFGMVLAIGILVDDAIVVVENVERLMV--EEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 501 FRPFALAIAFSLLASLLVSITLVPALAATL-----------------FKKGVKRRNKQHQEGLGVVsttYKKVLHWslnh 563
Cdd:PRK09577 466 YRQFALSLAVSIGFSAFLALSLTPALCATLlkpvdgdhhekrgffgwFNRFVARSTQRYATRVGAI---LKRPLRW---- 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 564 kwiVIILSTLILVATIVFggPRLGTSFISAGDD-KFLAITYTPKpGETEQAVLNHAKDVEKYLKQKKHVKTIqYSVGGSS 642
Cdd:PRK09577 539 ---LVVYGALTAAAALLF--TRLPTAFLPDEDQgNFMVMVIRPQ-GTPLAETMQSVREVESYLRRHEPVAYT-FALGGFN 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 643 pVDPTGSTNSMAIMVEYD-NDTPNFDVEADKIIKHVDgfKHPGEWKNQ-----------DLGTGAGNKSVEVTVKGPSMD 710
Cdd:PRK09577 612 -LYGEGPNGGMIFVTLKDwKERKAARDHVQAIVARIN--ERFAGTPNTtvfamnspalpDLGSTSGFDFRLQDRGGLGYA 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 711 AIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVK 790
Cdd:PRK09577 689 AFVAAREQLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQ 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 791 QNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDKDVGGTTRQVMSKINNlDKPN 870
Cdd:PRK09577 769 ADGRHRLDPDDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAA-TLPA 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 871 NVKVNIGGAS--DDINNAMTQLAFAM--------LAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIALLITGETI 940
Cdd:PRK09577 848 GIGYAWSGQSfeERLSGAQAPMLFALsvlvvflaLAAL----------YESWSIPFAVMLVVPLGVIGAVLGVTLRGMPN 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 941 SVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLA 1020
Cdd:PRK09577 918 DIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIG 997
|
1050 1060 1070
....*....|....*....|....*....|....*
gi 686251466 1021 ATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR 1055
Cdd:PRK09577 998 TGVLGGVITATVLAVFLVPLFFVVVGRLFDVGPRR 1032
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
33-1055 |
9.43e-54 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 204.37 E-value: 9.43e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKID---NQVRSLAYVKNVKTQSiqNASIVTVEYENNTDMDKAEEQ 109
Cdd:PRK15127 29 KLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEqnmNGIDNLMYMSSNSDST--GTVQITLTFESGTDADIAQVQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 110 LKKEIDKIK--FKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKK--VTKVLNEQLIPKLQTVDGVQNAQLNGqTNREIT 185
Cdd:PRK15127 107 VQNKLQLAMplLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQedISDYVAANMKDPISRTSGVGDVQLFG-SQYAMR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 186 LKFKQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDK--------DKSIVVDGQYQSVDAFKNInipltlaggqgqsq 257
Cdd:PRK15127 186 IWMNPNELNKFQLTPVDVINAIKAQNAQVAAG--QLGGTppvkgqqlNASIIAQTRLTSTEEFGKI-------------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 258 sqsdnkqnsaMSDVNQASPQqnskasapnnisgmptAKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDAN---TV 333
Cdd:PRK15127 250 ----------LLKVNQDGSR----------------VRLRDVAKIELGgENYDIIAEFNGQPASGLGIKLATGANaldTA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 334 QVAKDVQRKIDTFVDENkdFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALI 413
Cdd:PRK15127 304 AAIRAELAKMEPFFPSG--LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 414 ALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFV 493
Cdd:PRK15127 382 VLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM--AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFF 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 494 SGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG-LGVVSTTYKKVLHW---SLNHkwivII 569
Cdd:PRK15127 460 GGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGfFGWFNRMFEKSTHHytdSVGN----IL 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 570 LST-------LILVATIVFGGPRLGTSFISAGDDK-FLAITYTPKPGETE--QAVLNHAKDVekYL-KQKKHVKTIqYSV 638
Cdd:PRK15127 536 RSTgrylvlyLIIVVGMAYLFVRLPSSFLPDEDQGvFLTMVQLPAGATQErtQKVLNEVTDY--YLtKEKNNVESV-FAV 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 639 GGSSpVDPTGSTNSMAIMVEYD-NDTPNFDVEADKI----------IKH--VDGFKHPGewkNQDLGTGAGNKSVEVTVK 705
Cdd:PRK15127 613 NGFG-FAGRGQNTGIAFVSLKDwADRPGEENKVEAItmratrafsqIKDamVFAFNLPA---IVELGTATGFDFELIDQA 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 706 GPSMDAIKSTVKDI-EQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKT 784
Cdd:PRK15127 689 GLGHEKLTQARNQLlGEAAKHPDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRV 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 785 VDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTDKDVGGTTRQVMSKIN 864
Cdd:PRK15127 769 KKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELA 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 865 NlDKPNNVKVNIGGASDDINNAMTQ----------LAFAMLAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIALL 934
Cdd:PRK15127 849 S-KLPTGVGYDWTGMSYQERLSGNQapalyaisliVVFLCLAAL----------YESWSIPFSVMLVVPLGVIGALLAAT 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 935 ITGETISVPSLIGMLMLIGIVVTNAIVLIDRVIN-NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSI 1013
Cdd:PRK15127 918 FRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDlMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGS 997
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|..
gi 686251466 1014 LISKGLAATVIGGLISSTLLTLVVVPVIYEIlftLKKRFTKR 1055
Cdd:PRK15127 998 GAQNAVGTGVMGGMVTATVLAIFFVPVFFVV---VRRRFSRK 1036
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
329-1055 |
1.87e-29 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 126.13 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 329 DANTVQVAKDVQRKIDTFVDENKDFNVT----KTMDTAKPVEKSLYTMVekaSLGTIVAIIVILLFLRNIRTTAISIISI 404
Cdd:COG1033 176 DLDRKEVVAEIRAIIAKYEDPGVEVYLTgfpvLRGDIAEAIQSDLAIFF---PLALLLILLLLFLFFRSLRGVLLPLLVV 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 405 PLSLLMALIALKLSDVSLNILT--LGALTVAIGrvIDDSIVVVeNIYRrltdsEEQLKGEN---LIISATTEVFKPIMSS 479
Cdd:COG1033 253 LLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIG--IDYGIHLL-NRYR-----EERRKGLDkreALREALRKLGPPVLLT 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 480 TLVTIIVFLPLVFvSGSvgEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVsttYKKVLHW 559
Cdd:COG1033 325 SLTTAIGFLSLLF-SDI--PPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGRL---LAKLARF 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 560 SLNHKWIVIILSTLILVATIvFGGPRLGTSFisagddkflaitytpkpgeteqavlnhakDVEKYLKQK----KHVKTIQ 635
Cdd:COG1033 399 VLRRPKVILVVALVLAVVSL-YGISRLKVEY-----------------------------DFEDYLPEDspirQDLDFIE 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 636 YSVGGSSPVDptgstnsmaIMVEYDNDTPNFDVEADKiikhvdgfkhpgewknqdlgtgagnksvevtvkgpsmdaiksT 715
Cdd:COG1033 449 ENFGGSDPLE---------VVVDTGEPDGLKDPEVLK------------------------------------------E 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 716 VKDIEQKMKQVKGLANVKSdLSQTYDQYEIKVDQNKAAENGISASQlamhlnENLPEKTVTTVKENGKTVDVKVKQNKQt 795
Cdd:COG1033 478 IDRLQDYLESLPEVGKVLS-LADLVKELNQALNEGDPKYYALPESR------ELLAQLLLLLSSPPGDDLSRFVDEDYS- 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 796 dwsedklnnitlkkptggtiklgdiatlvktttpskltqeqgdyATTVSAKVtdKDVGGTT-----RQVMSKINNLDKPN 870
Cdd:COG1033 550 --------------------------------------------AARVTVRL--KDLDSEEikalvEEVRAFLAENFPPD 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 871 NVKVNIGGAS---DDINNAMTQ-----------LAFAMLAAiiivylilviTFKGGLAPFTILFSLPFTVIGVIIALLIT 936
Cdd:COG1033 584 GVEVTLTGSAvlfAAINESVIEsqirslllallLIFLLLLL----------AFRSLRLGLISLIPNLLPILLTFGLMGLL 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 937 GETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFgqdSSILIS 1016
Cdd:COG1033 654 GIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF---SSFPPL 730
|
730 740 750
....*....|....*....|....*....|....*....
gi 686251466 1017 KGLAATVIGGLISSTLLTLVVVPViyeILFTLKKRFTKR 1055
Cdd:COG1033 731 ADFGLLLALGLLVALLAALLLLPA---LLLLLDPRIAKK 766
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-526 |
1.79e-27 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 120.59 E-value: 1.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 3 KKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNV 82
Cdd:COG0841 516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 83 KT-------QSIQNASIVTVEY----ENNTDMDKAEEQLKKEIDKIK-FKDEVGQPELRRNSMDAfpvlAYSFSNKENDL 150
Cdd:COG0841 596 FSvvgfsggGSGSNSGTIFVTLkpwdERDRSADEIIARLREKLAKIPgARVFVFQPPAGGLGSGA----PIEVQLQGDDL 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 151 KKVTKVLnEQLIPKLQTVDGVQNAQLNGQTNR-EITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIV 229
Cdd:COG0841 672 EELAAAA-EKLLAALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVR 750
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 230 V--DGQY-QSVDAFKNINIPltlaggqgqsqsqsdnkqnsamsdvnqaspqqnskasapnNISGMPTAkLGDLADITVGD 306
Cdd:COG0841 751 VqaPEEDrNSPEDLENLYVR----------------------------------------TPDGEMVP-LSSVATIEEGT 789
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 307 VRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKID----------TFVDENKDFNvtKTMDTakpvekslytmvekA 376
Cdd:COG0841 790 GPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAelklppgvsiEFTGQAEEEQ--ESFSS--------------L 853
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 377 SLGTIVAIIVILLFL----RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIyrrl 452
Cdd:COG0841 854 GLAFLLALLLVYLVLaaqfESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA---- 929
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686251466 453 tdSEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPAL 526
Cdd:COG0841 930 --NQLREEGMSLreaILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVL 1004
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
320-538 |
4.15e-20 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 96.47 E-value: 4.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 320 VNLQITKAQDANTVQVAKDVQRKIDT-FVDENKDFNVT-------KTMDTakpVEKSLYTMvekaSLGTIVAIIVILLFL 391
Cdd:COG1033 553 VTVRLKDLDSEEIKALVEEVRAFLAEnFPPDGVEVTLTgsavlfaAINES---VIESQIRS----LLLALLLIFLLLLLA 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 392 -RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENiYRrltdsEEQLKGENL---IIS 467
Cdd:COG1033 626 fRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSR-YR-----EERRKGGDLeeaIRR 699
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686251466 468 ATTEVFKPIMSSTLVTIIVFLPLVFvsgSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRR 538
Cdd:COG1033 700 ALRTTGKAILFTSLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
99-540 |
1.17e-15 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 82.38 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 99 NNTDMD---KAEEQLKKEIDKIKFKDEVgqpelrRNSMDAFPVLAYSFS------NKE---------------NDLKkvt 154
Cdd:COG3696 615 NMSETFvilKPRSEWRSGRTKEELIAEM------REALEQIPGVNFNFSqpiqmrVDEllsgvradvavkifgDDLD--- 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 155 kVLN---EQLIPKLQTVDGVQNAQLNGQTN-REITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVV 230
Cdd:COG3696 686 -VLRrlaEQIEAVLKTVPGAADVQVERVTGlPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVV 764
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 231 ---DGQYQSVDAFKNINIPLtlaggqgqsqsqsdnkqnsamsdvnqaspqqNSKASAPnnisgmptakLGDLADITVGDV 307
Cdd:COG3696 765 rlpEELRDDPEAIRNLPIPT-------------------------------PSGAQVP----------LSQVADIEVVEG 803
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 308 RTSISKTNGKDAVNLQITkAQDANTVQVAKDVQRKIDTFVDenkdfnvtktmdtakpveksL---YTMV--------EKA 376
Cdd:COG3696 804 PNQISRENGRRRIVVQAN-VRGRDLGSFVAEAQAKVAEQVK--------------------LppgYYIEwggqfenlQRA 862
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 377 S--LGTIV----AIIVILLFL--RNIRTTAISIISIPLSLLMALIALKLSDVSLNIltlgalTVAIGRV------IDDSI 442
Cdd:COG3696 863 TarLAIVVplalLLIFLLLYLafGSVRDALLILLNVPFALIGGVLALWLRGMPLSV------SAGVGFIalfgvaVLNGV 936
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 443 VVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFvSGSVG-EMFRPFALAIAFSLLASLLVSIT 521
Cdd:COG3696 937 VLVSYINQLR---AEGLDLREAIIEGALERLRPVLMTALVAALGLLPMAL-STGPGsEVQRPLATVVIGGLITSTLLTLL 1012
|
490
....*....|....*....
gi 686251466 522 LVPALAATLFKKGVKRRNK 540
Cdd:COG3696 1013 VLPALYLLFGRRRLRRAAA 1031
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
4-541 |
3.04e-15 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 80.96 E-value: 3.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 4 KLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISV-TTTMPGATP-QSTqdEISSKIDNQVRSLAYVKN 81
Cdd:TIGR00914 528 PLLERVLAWPAVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYqALRIPGTSLaQSV--AMQQTLEKLIKSFPEVAR 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 82 V--KTQSIQ--------NASIVTVEYE--------NNTDMDKAEEQLKKEIDKIKFKDEVGQP-ELRRNSMDA---FPVL 139
Cdd:TIGR00914 606 VfaKTGTAEiatdpmppNASDTYIILKpesqwpegKKTKEDLIEEIQEATVRIPGNNYEFTQPiQMRFNELISgvrSDVA 685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 140 AYSFSNKENDLKKVTKVLNEQLipklQTVDGVQNA---QLNGqtNREITLKFKQNELEKYGLTADDVENYLKTATRTTPL 216
Cdd:TIGR00914 686 VKVFGDDLDDLDATAEKISAVL----KGVPGAADVkveQTTG--LPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMS 759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 217 GLFQFGDKDKSIVV---DGQYQSVDAFKNINIPLTLAGGQGqsqsqsdnkqnsamsdvnqaspqqnsKASAPnnisgmpt 293
Cdd:TIGR00914 760 GETFEGDRRFDIVIrlpESLRESPQALRQLPIPLPLSEDAR--------------------------KQFIP-------- 805
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 294 akLGDLADITVGDVRTSISKTNGKDAVNLQITkAQDANTVQVAKDVQRKIDTFVDENKDFNVT--KTMDTAKPVEKSLYT 371
Cdd:TIGR00914 806 --LSDVADLRVSPGPNQISRENGKRRVVVSAN-VRGRDLGSFVDDAKKAIAEQVKLPPGYWITwgGQFEQLQSATKRLQI 882
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 372 MVEKASLgtivaIIVILLFL--RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIy 449
Cdd:TIGR00914 883 VVPVTLL-----LIFVLLYAafGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFI- 956
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 450 RRLTDSEEQLKgENLIISATTEVfKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAAT 529
Cdd:TIGR00914 957 RKLLEEGPSLD-EAVYEGALTRV-RPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRL 1034
|
570
....*....|..
gi 686251466 530 LFKKGVKRRNKQ 541
Cdd:TIGR00914 1035 VHRRRHKGRKEH 1046
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
320-593 |
1.83e-13 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 74.80 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 320 VNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLF-LRNIRTTA 398
Cdd:COG2409 118 VTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLvFRSLVAAL 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 399 ISIISIPLSLL--MALIAL-----KLSDVSLNILTLgaLTVAIGrvIDDSIVVVeNIYRrltdsEEQLKGENL---IISA 468
Cdd:COG2409 198 LPLLTAGLAVGvaLGLLALlaaftDVSSFAPNLLTM--LGLGVG--IDYALFLV-SRYR-----EELRAGEDReeaVARA 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 469 TTEVFKPIMSSTLVTIIVFLPLVFVSGSvgeMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGV 548
Cdd:COG2409 268 VATAGRAVLFSGLTVAIALLGLLLAGLP---FLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRVFWPRRPRRRRAAAP 344
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 686251466 549 VSTTYKKVLHWSLNHKWIVIILSTLILVA-TIVFGGPRLGTSFISA 593
Cdd:COG2409 345 ESGFWRRLARAVVRRPVPVLVAAVAVLLAlALPALGLRLGLPDADS 390
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
4-526 |
3.48e-13 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 74.25 E-value: 3.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 4 KLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVK 83
Cdd:pfam00873 518 KLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVF 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 84 TQ---------SIQNASIVTVEYENNTDMDKAE-------EQLKKEIDKIKFKDEVGQ--PELRRNSMDAFPVLAYSFSN 145
Cdd:pfam00873 598 AVtgfafsgdnNGPNSGDAFISLKPWKERPGPEksvqaliERLRKALKQIPGANVFLFqpIQLRGLGTISGFRSDLQVKI 677
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 146 KENDLKKVTKvLNEQLIPKLQTVDGVQNAQLNGQTN-REITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDK 224
Cdd:pfam00873 678 FGDDLDALDE-ARNQILAALAQLPGLSDVRSDGQEDqPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGR 756
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 225 DKSIVVdgqyQSVDAFKNinipltlaggqgqsqsqsdnkqnsamsdvnqaSPQQNSKASAPNNISGMptAKLGDLADITV 304
Cdd:pfam00873 757 VYDVVV----QLPEDFRS--------------------------------SPEDIGQLYVRNPYGKM--IPLSAFAKIEW 798
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 305 GDVRTSISKTNGKDAVNLQITKAQDANTVQvAKDVQRKIDTFVDENKDFNVTKTMDTAkpVEKSLYTMVEKASLGTIVAI 384
Cdd:pfam00873 799 GYGPPSINRYNGFRSIVISGNVAAGDSLGD-AMEAMAQIAKQVKLPPGYGYTWTGQFE--QEQLAGNSLPILIALALLVV 875
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 385 IVILLFL-RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIyrrltDSEEQLKGEN 463
Cdd:pfam00873 876 FLVLAALyESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFA-----NELREQEGKS 950
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686251466 464 L---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPAL 526
Cdd:pfam00873 951 LeeaILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVF 1016
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
365-528 |
2.80e-10 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 64.63 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 365 VEKSLYTMVE---KASLGTIVAIIVILLF-LRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDD 440
Cdd:TIGR03480 703 ILESGDTVVGaflQAFIYALVAITVLLLLtLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDF 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 441 SIVVVENiYRRLTDSeeqlkgENLIISATTevfKPIMSSTLVTIIVFLPLVFVS----GSVGEMfrpFALAIAFSLLASL 516
Cdd:TIGR03480 783 GIYMVHR-WRNGVDS------GNLLQSSTA---RAVFFSALTTATAFGSLAVSShpgtASMGIL---LSLGLGLTLLCTL 849
|
170
....*....|..
gi 686251466 517 LVsitlVPALAA 528
Cdd:TIGR03480 850 IF----LPALLG 857
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
375-530 |
2.03e-09 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 60.38 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 375 KASLGTIVAIIVILLFL-RNIRTTAISIISIPLSLLMAL---------IALKLSDVSLNILTlgALTVAIGrvIDDSIVV 444
Cdd:pfam03176 146 LIEAVTLVVIFIILLIVyRSVVAALLPLLTVGLSLGAAQglvailahiLGIGLSTFALNLLV--VLLIAVG--TDYALFL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 445 VENiYRrltdsEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFvsgSVGEMFRPFALAIAFSLLASLLVSIT 521
Cdd:pfam03176 222 VSR-YR-----EELRAGEDReeaVIRAVRGTGKVVTAAGLTVAIAMLALSF---ARLPVFAQVGPTIAIGVLVDVLAALT 292
|
....*....
gi 686251466 522 LVPALAATL 530
Cdd:pfam03176 293 LLPALLALL 301
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
306-588 |
2.09e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 58.31 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 306 DVRTSISKTNGKDAVNLQITkaqdaNTVQVAKDVQRKIdtfvdeNKDFNVTktmdtakpvekslytmvekASLGTIVAII 385
Cdd:TIGR00921 159 DVERSLERTNPPSGKFLDVT-----GSPAINYDIEREF------GKDMGTT-------------------MAISGILVVL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 386 VILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYrrltdsEEQLKGENL- 464
Cdd:TIGR00921 209 VLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE------EERDIGRAKg 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 465 --IISATTEVFKPIMSSTLVTIIVFLPLvfvSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATL--FKKGVKRRNK 540
Cdd:TIGR00921 283 eaIVTAVRRTGRAVLIALLTTSAGFAAL---ALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIdiGREKVKKEII 359
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 686251466 541 QHQEGLGVVSTTYKKVLHWSLNHKWiVIILSTLILVATIVFGGPRLGT 588
Cdd:TIGR00921 360 AIGGKSSEIEEELSKVLSITVRHPV-PALVAALIITGLGLYGAAGIKP 406
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
266-1042 |
5.77e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 53.69 E-value: 5.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 266 SAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLaditVGDVRTSISKTNGKDAVNLQitkaqdaNTVQVAKDVQRKIDt 345
Cdd:TIGR00921 98 DIMRQIPGNFPLPVTMPEVRPLMSEYPRSKEMFL----SKDHTVAIIIVQLKSDADYK-------QVVPIYNDVERSLE- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 346 FVDENKDFNVTKTMDTA---KPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSL 422
Cdd:TIGR00921 166 RTNPPSGKFLDVTGSPAinyDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 423 NILTLGALTVAIGRVIDDSIVVVENIYrrltdsEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLvfvSGSVGE 499
Cdd:TIGR00921 246 YATTLLAVPMLIGVGIDYGIQTLNRYE------EERDIGRAKgeaIVTAVRRTGRAVLIALLTTSAGFAAL---ALSEFP 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 500 MFRPFALAIAFSLLASLLVSITLVPALAATL--FKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWiVIILSTLILVA 577
Cdd:TIGR00921 317 MVSEFGLGLVAGLITAYLLTLLVLPALLQSIdiGREKVKKEIIAIGGKSSEIEEELSKVLSITVRHPV-PALVAALIITG 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 578 TIVFGGPRLGTsfisagddkflaitytpkpgETeqavlnhakDVEKYLKQK----KHVKTIQYSVGGSSpvdptgstNSM 653
Cdd:TIGR00921 396 LGLYGAAGIKP--------------------EV---------NIEKFIPQDlpslQARKVIESHMGGSH--------DFA 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 654 AIMVEYDndtpnfDVEADKIIKHVDGFKhpgewknqdlgtgagnksvevtvkgpsmdaikstvkdieQKMKQVKGLANVk 733
Cdd:TIGR00921 439 TILVKAD------DVRDPELVRFMDELS---------------------------------------RDIKATGVAARV- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 734 sdlsqtYDQYEIkVDQNKAAENGISASQLAMhlnENLPEKTVTTVKEngktvdvkvkqnkqtdwsedklnnitlkkptGG 813
Cdd:TIGR00921 473 ------FGAPSI-IDLVKEVEGLPAPERSAL---EPIPEDEEGGYIS-------------------------------GG 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 814 TIKLGDIATLVKTTTPskltQEQGDYattvsakvtdkdvggttrqVMSKINNLDKPNNVKVNIGGAS---DDINNAMTQ- 889
Cdd:TIGR00921 512 QIKVAVIQVQLKQGEP----KVQGRK-------------------ILRDVQHEHPPPGVKVGVTGLPvafAEMHELVNEg 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 890 LAFAMLAAIIIVYLILVITFKGGLAPFTILFSLpFTVIGVIIALLITGETISVPSLIGML-MLIGIVVTNAIVLIDRVIN 968
Cdd:TIGR00921 569 MRRMTIAGAILVLMILLAVFRNPIKAVFPLIAI-GSGILWAIGLMGLRGIPSFLAMATTIsIILGLGMDYSIHLAERYFE 647
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686251466 969 nEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQdSSILISKGLAATVigGLISSTLLTLVVVPVIY 1042
Cdd:TIGR00921 648 -ERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSH-FPIMRNFGLVQGI--GVLSSLTAALVVFPALL 717
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
373-585 |
2.89e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.39 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 373 VEKASLGTIVAIIVILLFL-RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSI-VVVENIYR 450
Cdd:COG4258 251 ISTIGLISLLGILLLLLLVfRSLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLGFGSSLIGVAVDYSLhYLTHRRAA 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 451 RLTDSEEQLKgenliisattEVFKPIMSSTLVTIIVFLPLVFvSGSvgEMFRPFALAIAFSLLASLLVSITLVPAlaatL 530
Cdd:COG4258 331 GEWDPRAALR----------RIWPTLLLGLLTTVLGYLALLF-SPF--PGLRQLGVFAAAGLLAAALTTLLWLPL----L 393
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 686251466 531 FKKGVKRRNKQHQEGLGVVsttykkVLHWSLNHKWIVIILSTLILVATIVFGGPR 585
Cdd:COG4258 394 LPRAAPRPPAPALALLARL------LARWPRRLRWLLALLAVLALASLLGLNRLK 442
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
378-525 |
4.98e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 378 LGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEE 457
Cdd:COG4258 647 LALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDKGELART 726
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686251466 458 QLkgeNLIISATTevfkpimsstlvTIIVFLPLVFVSGSVgemFRPFALAIAFSLLASLLVSITLVPA 525
Cdd:COG4258 727 LL---SILLAALT------------TLLGFGLLAFSSTPA---LRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
377-514 |
5.51e-06 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 50.60 E-value: 5.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 377 SLGTIVAIIVILLF--LRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVE--NIYRRl 452
Cdd:PRK09579 849 TFGLALAIIFLVLAaqFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEfaNQLRH- 927
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686251466 453 tdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSG-----------------SVGEMFRPFALAIAFSLLA 514
Cdd:PRK09579 928 ---EQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGagavsrfdiglviatgmSIGTLFTLFVLPCIYTLLA 1003
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
348-577 |
2.96e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 48.07 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 348 DENKDFNVTKTMDTAKPVE--KSLYTMVEKASLGTIVAIIVILLF-LRNIRTtaisIISIPLSLLMALI---ALKLSDV- 420
Cdd:TIGR03480 244 DEDHGVTVRLTGEVALSDEelATVSEGATVAGLLSFVLVLVLLWLaLRSPRL----VFAVLVTLIVGLIltaAFATLAVg 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 421 SLNILTLGALTVAIGRVIDDSIVVVENiYRrltdsEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGS- 496
Cdd:TIGR03480 320 HLNLISVAFAVLFIGLGVDFAIQFSLR-YR-----EERFRGGNHreaLSVAARRMGAALLLAALATAAGFFAFLPTDYKg 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 497 VGEMfrpfALAIAFSLLASLLVSITLVPALaATLFKKgvKRRNKqhqeglGVVSTTYKKVLHWSLNH-KWIVIIlsTLIL 575
Cdd:TIGR03480 394 VSEL----GIIAGTGMFIALFVTLTVLPAL-LRLLRP--PRRRK------PPGYATLAPLDAFLRRHrRPVLGV--TLIL 458
|
..
gi 686251466 576 VA 577
Cdd:TIGR03480 459 GI 460
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
375-520 |
3.21e-05 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 45.71 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 375 KASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVvvenIYRRLTD 454
Cdd:TIGR00916 51 IALLIGLVLVLLYMLLRYEWRGAIAAIAALVHDVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVV----IFDRIRE 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 455 SEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPL-VFVSGSVgemfRPFALAIAFSLLASLLVSI 520
Cdd:TIGR00916 127 ELRKYKGRTFreaINLGINQTLSRIIDTNVTTLLAVLALyVFGGGAI----KGFALTLGIGVIAGTYSSI 192
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
381-592 |
1.01e-04 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 46.38 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 381 IVAIIVILLF-LRNIRTT-AISIISIPLSLLMALIALklsdVSLN-ILTLG---ALTVAIGRVIDDSIVVVENIyrrltd 454
Cdd:PRK13024 273 IIGFALIFLFmLVYYGLPgLIANIALLLYIFLTLGAL----SSLGaVLTLPgiaGLVLGIGMAVDANVLIFERI------ 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 455 sEEQLKGENLIISATTEVFK----PIMSSTLVTIIV-FLPLVFVSGSVgemfRPFALAIAFSLLASLLVSITLVPALAAT 529
Cdd:PRK13024 343 -KEELRKGKSLKKAFKKGFKnafsTILDSNITTLIAaAILFFFGTGPV----KGFATTLIIGILASLFTAVFLTRLLLEL 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686251466 530 LFKKGVKRR--NKQHQEGLGVVSTTYKKVLHWSL--NHKWIVIILSTLILVATIVF--GGPRLGTSFIS 592
Cdd:PRK13024 418 LVKRGDKKPflFGVKKKKIHNINEGVTIFDRIDFvkKRKWFLIFSIVLVIAGIIIFfiFGLNLGIDFTG 486
|
|
| SecD_SecF |
pfam02355 |
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ... |
372-533 |
9.66e-04 |
|
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.
Pssm-ID: 280510 [Multi-domain] Cd Length: 189 Bit Score: 41.44 E-value: 9.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 372 MVEKASLGTIVAIIVIL--LFLRNIRTTAI-SIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENI 448
Cdd:pfam02355 29 LARKAVLALLFALLLILiyVGLRFEWRFALgAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSVNDTVVVFDRV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 449 YRRLTdseeQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAA 528
Cdd:pfam02355 109 RENLR----KKTRATLNEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVGVIVGTYSSIFIASPILL 184
|
....*
gi 686251466 529 TLFKK 533
Cdd:pfam02355 185 DLGER 189
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
378-544 |
9.98e-04 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 43.18 E-value: 9.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 378 LGTIVAIIVILLFLRNIRTTAISIIS-IPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVEniYRRLTDSE 456
Cdd:PRK10503 871 VAAVVAMYIVLGVLYESFIHPITILStLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMID--FALAAERE 948
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 457 EQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALaATLFKK--- 533
Cdd:PRK10503 949 QGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVI-YLLFDRlal 1027
|
170
....*....|.
gi 686251466 534 GVKRRNKQHQE 544
Cdd:PRK10503 1028 YTKSRFPRHEE 1038
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
348-518 |
2.10e-03 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 41.96 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 348 DENKDFNVTKTMDTAKPVekSLYTMVEKASLGTIVaIIVILLFlrnirttAISIISIPLslLMALIALKLSDVSLNILTL 427
Cdd:pfam02460 614 DQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIV-ITLICMF-------IVCFLFIPN--PPCVFVITLAIASIDIGVF 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686251466 428 GALT---------------VAIGRVIDDSIVVVENIYR-RLTDSEEQlkgenlIISATTEVFKPIMSSTLVTIIVFLPLV 491
Cdd:pfam02460 682 GFLSlwgvdldpismitiiMSIGFSVDFSAHIAYHFVRsRGDTPAER------VVDALEALGWPVFQGGLSTILGVLVLL 755
|
170 180
....*....|....*....|....*...
gi 686251466 492 FVSGSVGEMF-RPFALAIAFSLLASLLV 518
Cdd:pfam02460 756 FVPSYMVVVFfKTVFLVVAIGLLHGLFI 783
|
|
| |
