|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
33-1052 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 761.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:COG0841 31 RLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITSTSSEGSSSITVEFELGTDIDEALVDVQN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 113 EIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQ 190
Cdd:COG0841 111 AVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 191 NELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamsh 270
Cdd:COG0841 191 DKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFENIVI------------------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 271 vnqaspqqnsKASASNNIsgmptaKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFvde 349
Cdd:COG0841 246 ----------RTNDGSVV------RLGDVARVEDGaEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEEL--- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 350 NKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNIL 425
Cdd:COG0841 307 QASLpegvELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNIL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 426 TLGALTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFA 505
Cdd:COG0841 387 TLFALVLAIGIVVDDAIVVVENIERHM---EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 506 LAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQE----GLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATiVF 581
Cdd:COG0841 464 LTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRafnrGFDRLTRGYGRLLRWALRHRKLTLLVALALLALS-VL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 582 GGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPvdpTGSTNSMAIMVEYDN 661
Cdd:COG0841 543 LFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGG---GSGSNSGTIFVTLKP 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 662 ----DTPNFDVEAD-----KVIKHADGFKHPGewknQDLGTGAGnKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANV 732
Cdd:COG0841 620 wderDRSADEIIARlreklAKIPGARVFVFQP----PAGGLGSG-APIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDV 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 733 KSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTG 812
Cdd:COG0841 695 RSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDG 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 813 GTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVT-NKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLA 891
Cdd:COG0841 775 EMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLApGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLG 854
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 892 FAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQ 971
Cdd:COG0841 855 LAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLRE 934
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 972 QGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKR 1051
Cdd:COG0841 935 EGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRR 1014
|
.
gi 686208002 1052 F 1052
Cdd:COG0841 1015 L 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
33-1042 |
2.94e-176 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 542.27 E-value: 2.94e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:pfam00873 29 SLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSSITLTFELGTDIDIARQDVQN 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 113 EIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTK--VLNEQLIPKLQTVDGVQNAQLNGQTNREITLKF 188
Cdd:pfam00873 109 RLQLATPLlpEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLrdYADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 189 KQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsam 268
Cdd:pfam00873 189 DPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIV----------------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 269 sHVNQASPqqnskasasnnisgmptAKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRK---ID 344
Cdd:pfam00873 246 -KNQDGSP-----------------VRLRDVATVELGsELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKlaeLK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 345 TFVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNI 424
Cdd:pfam00873 308 PTFPQGVEIVVV--YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINT 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 425 LTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPF 504
Cdd:pfam00873 386 LTLGGLVLAIGLVVDDAIVVVENIERVL--EENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQF 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 505 ALAIAFSLLASLLVSITLVPALAATLfkkgVKRRNKQHQEGLGVVSTT--------YKKVLHWSLNHKWIVIILSTLILV 576
Cdd:pfam00873 464 AITIVLAILLSVLVALTLTPALCATL----LKPRREPKHGGFFRWFNRmfdrltrgYAKLLAKVLRHTAVVLLVALLLVV 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 577 ATiVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQySVGGSSPVDPTGSTNS--MA 654
Cdd:pfam00873 540 GS-VWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVF-AVTGFAFSGDNNGPNSgdAF 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 655 IMVEYDNDTPNFDVEADKVIKHADG--FKHPGEWKN-------QDLGTGAG-NKSVEVTVKGPSMDAIKSTVKDIEQKMK 724
Cdd:pfam00873 618 ISLKPWKERPGPEKSVQALIERLRKalKQIPGANVFlfqpiqlRGLGTISGfRSDLQVKIFGDDLDALDEARNQILAALA 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 725 QVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNN 804
Cdd:pfam00873 698 QLPGLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQ 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 805 ITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKI-NNLDKPNNVKVNIGGASDDI 883
Cdd:pfam00873 778 LYVRNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIaKQVKLPPGYGYTWTGQFEQE 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 884 NNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLI 963
Cdd:pfam00873 858 QLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMV 937
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 964 DrVIN--NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLF--GQDSSILisKGLAATVIGGLISSTLLTLVVVP 1039
Cdd:pfam00873 938 E-FANelREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALstGAGSELQ--QPLGIVVFGGLVTSTVLTLLVVP 1014
|
...
gi 686208002 1040 VIY 1042
Cdd:pfam00873 1015 VFY 1017
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1045 |
2.22e-153 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 482.61 E-value: 2.22e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 1 MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVK 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 81 NVKTQSIQNASIVTVEYENNTD-----------MDKAEEQLKKEIdkikfkdevgQPELrrnSMDAFP---VLAYSFSNK 146
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDiywarqlvlerLQQVREQLPAGV----------TPEL---GPISTGlgeIYQYTLESD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 147 EN--DLKKVTKVLNEQLIPKLQTVDGVqnAQLN--GQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFG 222
Cdd:COG3696 148 PGkySLMELRTLQDWVIRPQLRSVPGV--AEVNsfGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 223 DKDKSIVVDGQYQSVDAFKNIniPLTlaggqgqsqsqsdnkqnsamshvnqaspqqnskasasnNISGMPTaKLGDLADI 302
Cdd:COG3696 226 GQEYLVRGIGLIRSLEDIENI--VVK--------------------------------------TRNGTPV-LLRDVAEV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 303 TVG-DVRTSISKTNGK-DAVNLQITKAQDANTVQVAKDVQRKIDTfVDEN--KDFNVTKTMDTAKPVEKSLYTMVEKASL 378
Cdd:COG3696 265 RIGpAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAE-LKPSlpEGVKIVPFYDRSDLIDRAIHTVTKNLLE 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 379 GTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQ 458
Cdd:COG3696 344 GALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRRLEENRAA 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 459 LKGEN---LIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGV 535
Cdd:COG3696 424 GTPRErleVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRGKV 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 536 KrrnkqHQEG--LGVVSTTYKKVLHWSLNHKWIVIILSTLILVATiVFGGPRLGTSFISA---GDdkfLAITYTPKPGET 610
Cdd:COG3696 504 P-----EKENplVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLA-LALFPRLGSEFLPEldeGD---LLVMATLPPGIS 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 611 EQAVLNHAKDVEKYLKQKKHVKTIQYSVG-GSSPVDPTGSTNS--MAIMVEYDNDTPNFDVEA--DKVIKHADGFkhPG- 684
Cdd:COG3696 575 LEESVELGQQVERILKSFPEVESVVSRTGrAEDATDPMGVNMSetFVILKPRSEWRSGRTKEEliAEMREALEQI--PGv 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 685 --EWkNQ-------DLGTGAgnKSvEVTVK--GPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAA 753
Cdd:COG3696 653 nfNF-SQpiqmrvdELLSGV--RA-DVAVKifGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAA 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 754 ENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLT 833
Cdd:COG3696 729 RYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQIS 808
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 834 QEQGDYATTVSAKVTNKDVGGTTRQVMSKIN-NLDKPNNVKVNIGGASDDINNAMTQLA----------FAMLAAiiivy 902
Cdd:COG3696 809 RENGRRRIVVQANVRGRDLGSFVAEAQAKVAeQVKLPPGYYIEWGGQFENLQRATARLAivvplallliFLLLYL----- 883
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 903 lilviTFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIE 982
Cdd:COG3696 884 -----AFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIE 958
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686208002 983 AGGTRIRPILMTAIATIGALVPLLFGQD--SSILisKGLAATVIGGLISSTLLTLVVVPVIYEIL 1045
Cdd:COG3696 959 GALERLRPVLMTALVAALGLLPMALSTGpgSEVQ--RPLATVVIGGLITSTLLTLLVLPALYLLF 1021
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
33-1045 |
1.54e-142 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 453.32 E-value: 1.54e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKK 112
Cdd:NF033617 28 KLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTITLQFRLGTDLDVALSEVQA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 113 EIDKIKFK--DEVGQPELRR--NSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKF 188
Cdd:NF033617 108 AINAAQSLlpSEAPDPPVYRkaNSADT-PIMYIGLTSEEMPRGQLTDYAERVLAPKLSQINGVGSVDVSGGQRPAMRVWL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 189 KQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsam 268
Cdd:NF033617 187 DPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYEDLVI----------------------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 269 shvnqaspqqnskasaSNNISGMPTaKLGDLADITVG--DVRtSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTf 346
Cdd:NF033617 244 ----------------KYADNGAPV-RLGDVATVELGaeNVR-NRAWANGVPAVVLGINRQPGANPIEVADEIRALLPE- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 347 VDEN--KDFNVTKTMDTAKPVEKSLYTmVEKASLGTI-VAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLN 423
Cdd:NF033617 305 LQETlpKNIKVNVLYDRTRFIRASIDE-VESTLLEAVaLVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSIN 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 424 ILTLGALTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRP 503
Cdd:NF033617 384 LLTLMALVLAIGLVVDDAIVVVENIHRHI---EEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFRE 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 504 FALAIAFSLLASLLVSITLVPALAATLFKKGVK--RRNKQHQEGLGVVSTTYKKVLHWSLNHKWIViilstlILVATIVF 581
Cdd:NF033617 461 FAVTLAGAVIISGIVALTLTPMMCSRLLKANEKpgRFARAVDRFFDGLTARYGRGLKWVLKHRPLT------LVVALATL 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 582 GGPRLGTSFISAG----DDKFLAITYTPKP-GETEQAVLNHAKDVEK-YLKQKKHVKTIQYSVGGSSPVDPTGSTnsMAI 655
Cdd:NF033617 535 ALLPLLYVFIPKElapsEDRGVIFGMIQAPqSISLDYMSAKMRDVEKiLSSDPEVQSLTSFNGVGGNPGDNTGFG--IIN 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 656 MVEYDNDtpnfDVEADKVIKHADGF--KHPGE----WKNQDL--GTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVK 727
Cdd:NF033617 613 LKPWDER----DVSAQEIIDRLRPKlaKVPGMdlflFPLQDLpgGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSP 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 728 GLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITL 807
Cdd:NF033617 689 QFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYV 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 808 KKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAM 887
Cdd:NF033617 769 RSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEG 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 888 TQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDrVI 967
Cdd:NF033617 849 SSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVE-FA 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 968 NNEQ--QGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEIL 1045
Cdd:NF033617 928 NELQrhQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLL 1007
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1055 |
6.78e-94 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 322.48 E-value: 6.78e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 1 MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVK 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 81 NVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVG-QPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNE 159
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGvSPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 160 Q---------LIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVV 230
Cdd:TIGR00914 161 TdlrtiqdwiIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 231 DGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamshvnqaspqqnskasasNNISGMPTaKLGDLADITVG-DVRT 309
Cdd:TIGR00914 241 PGQVQSMDDIRNIVI----------------------------------------ATGEGVPI-RIRDVARVQIGkELRT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 310 SISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFvdeNKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAII 385
Cdd:TIGR00914 280 GAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETI---NKTLpegvEIVTTYDRSQLVDAAIATVKKNLLEGALLVIV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 386 VILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALtvAIGRVIDDSIVVVENIYRRLTDSEEQLkGENL- 464
Cdd:TIGR00914 357 ILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLt 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 465 -------IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKR 537
Cdd:TIGR00914 434 lkerlheVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVAE 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 538 RNKQHqegLGVVSTTYKKVLHWSLNHKwIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNH 617
Cdd:TIGR00914 514 KENRL---MRVLKRRYEPLLERVLAWP-AVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAM 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 618 AKDVEKYLKQKKHVKTIQYSVG----GSSPVDPTGSTNSmaIMVEYDNDTPN-FDVEADKVIKHADG----------FKH 682
Cdd:TIGR00914 590 QQTLEKLIKSFPEVARVFAKTGtaeiATDPMPPNASDTY--IILKPESQWPEgKKTKEDLIEEIQEAtvripgnnyeFTQ 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 683 PGEWKNQDLGTGAgNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQL 762
Cdd:TIGR00914 668 PIQMRFNELISGV-RSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDV 746
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 763 AMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGG-----TIKLGDIATLVKTTTPSKLTQEQG 837
Cdd:TIGR00914 747 QDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENG 826
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 838 DYATTVSAKVTNKDVGGTTRQVMSKINNLDK-PNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPF 916
Cdd:TIGR00914 827 KRRVVVSANVRGRDLGSFVDDAKKAIAEQVKlPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDAL 906
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 917 TILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAI 996
Cdd:TIGR00914 907 LVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTAL 986
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*....
gi 686208002 997 ATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEIlfTLKKRFTKR 1055
Cdd:TIGR00914 987 VASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRL--VHRRRHKGR 1043
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
15-1042 |
4.72e-82 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 288.94 E-value: 4.72e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 15 AIFLMVVLVvlggvYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASI-V 93
Cdd:TIGR00915 16 AIIIMLAGT-----LSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSDGSMtI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 94 TVEYENNTDMDKAEEQLKKEIDKI--KFKDEVGQPELR--RNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVD 169
Cdd:TIGR00915 91 TLTFEQGTDPDIAQVQVQNKLQLAtpLLPQEVQRQGVRveKASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDPLSRLE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 170 GVQNAQLNGqTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDK--------DKSIVVDGQYQSVDAFK 241
Cdd:TIGR00915 171 GVGDVQLFG-SQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAG--QLGGLpavpgqqlNATIIAQTRLQTPEQFE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 242 NINIpltlaggqgqsqsqsdnKQNSAMSHVnqaspqqnskasasnnisgmptaKLGDLADITVG-DVRTSISKTNGKDAV 320
Cdd:TIGR00915 248 NILL-----------------KVNTDGSQV-----------------------RLKDVARVELGgENYSISARFNGKPAS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 321 NLQITKAQDANTVQVAKDVQRKIDtfvDENKDF----NVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRT 396
Cdd:TIGR00915 288 GLAIKLATGANALDTAKAVKAELA---VLEPFFpqgmKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 397 TAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPI 476
Cdd:TIGR00915 365 TLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVM--AEEGLPPKEATRKSMGQIQGAL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 477 MSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG--------LGV 548
Cdd:TIGR00915 443 VGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIEKGEHHEKKGGffgwfnrmFDS 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 549 VSTTYKKVLHWSLNHKWIVIILSTLILVATiVFGGPRLGTSFISAGDDK-FLAITYTPkPGETEQAVLNHAKDVEKYL-- 625
Cdd:TIGR00915 523 STHGYENGVGKILRRRGRYLLVYVLLVGGM-VFLFVRLPTSFLPDEDQGvFMTIVQLP-AGATAERTQAVLAQVTKYLla 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 626 KQKKHVKTIqYSVGGSSpvdPTGSTNSMAIMVEY-----DNDTPNFDVEAdkVIKHAdgFKHPGEWKN-----------Q 689
Cdd:TIGR00915 601 KEKANVESV-FTVNGFS---FAGRGQNMGMAFIRlkdweERTGKENSVFA--IAGRA--TGHFMQIKDamviafvppaiL 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 690 DLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNEN 769
Cdd:TIGR00915 673 ELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTA 752
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 770 LPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTn 849
Cdd:TIGR00915 753 WGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAA- 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 850 kdVGGTTRQVMSKINNLDK--PNNVKVNIGGASDDINNAMTQ----------LAFAMLAAIiivylilvitFKGGLAPFT 917
Cdd:TIGR00915 832 --PGVSTGQAMAAMEAIAQklPPGFGFSWTGMSYEERLSGSQapalyalsllVVFLCLAAL----------YESWSIPVS 899
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 918 ILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIA 997
Cdd:TIGR00915 900 VMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLA 979
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*
gi 686208002 998 TIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIY 1042
Cdd:TIGR00915 980 FILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFY 1024
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
34-1055 |
4.13e-74 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 265.83 E-value: 4.13e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 34 LKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKE 113
Cdd:PRK10503 41 LPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 114 IDKIK--FKDEVGQPEL--RRNSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFK 189
Cdd:PRK10503 121 INAATnlLPSDLPNPPVysKVNPADP-PIMTLAVTSTAMPMTQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 190 QNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLtlaggqgqsqsqsdnkQNSAms 269
Cdd:PRK10503 200 AQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLIIAY----------------QNGA-- 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 270 hvnqaspqqnskasasnnisgmpTAKLGDLADITVGDVRTSISK-TNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVD 348
Cdd:PRK10503 262 -----------------------PIRLGDVATVEQGAENSWLGAwANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 349 E-NKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTL 427
Cdd:PRK10503 319 SlPKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 428 GALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGEnliISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALA 507
Cdd:PRK10503 399 MALTIATGFVVDDAIVVIENISRYIEKGEKPLAAA---LKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVT 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 508 IAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG----LGVVSTTYKKVLHWSLNHKWIV--IILSTLILVATIVF 581
Cdd:PRK10503 476 LAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRAsermFDRVIAAYGRGLAKVLNHPWLTlsVALSTLLLTVLLWI 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 582 GGPRlgtSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGgsspVDPTGST-NSMAIMVeyd 660
Cdd:PRK10503 556 FIPK---GFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVG----VDGTNPSlNSARLQI--- 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 661 NDTPnFDVEADKVIKHADGFKH-----PGE----WKNQDL--GTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGL 729
Cdd:PRK10503 626 NLKP-LDERDDRVQKVIARLQTavakvPGVdlylQPTQDLtiDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQL 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 730 ANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKK 809
Cdd:PRK10503 705 SDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTS 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 810 PTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVT-NKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMT 888
Cdd:PRK10503 785 SDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPdGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 889 QLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVIN 968
Cdd:PRK10503 865 STVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALA 944
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 969 NE-QQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYeILFT 1047
Cdd:PRK10503 945 AErEQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIY-LLFD 1023
|
....*...
gi 686208002 1048 LKKRFTKR 1055
Cdd:PRK10503 1024 RLALYTKS 1031
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
39-1055 |
1.94e-73 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 263.51 E-value: 1.94e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 39 LPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIK 118
Cdd:PRK10614 37 LPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 119 FKDEVG---QPELRR-NSMDAfPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELE 194
Cdd:PRK10614 117 SLLPSGmpsRPTYRKaNPSDA-PIMILTLTSDTYSQGQLYDFASTQLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 195 KYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIpltlaggqgqsqsqsdnkqnsamsHVNQA 274
Cdd:PRK10614 196 NQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLII------------------------HYNNG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 275 SPqqnskasasnnisgmptAKLGDLADIT--VGDVRTSiSKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTF---VDE 349
Cdd:PRK10614 252 AA-----------------VRLGDVATVTdsVQDVRNA-GMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELretIPA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 350 NKDFNVTKtmDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGA 429
Cdd:PRK10614 314 AIDLQIAQ--DRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 430 LTVAIGRVIDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIA 509
Cdd:PRK10614 392 LTIATGFVVDDAIVVLENISRHL---EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 510 FSLLASLLVSITLVPALAATLFkKGVKRRNKQHQEGLG----VVSTTYKKVLHWSLNH-KWI-VIILSTLILVATIVFGG 583
Cdd:PRK10614 469 VAIGISLLVSLTLTPMMCAWLL-KSSKPREQKRLRGFGrmlvALQQGYGRSLKWVLNHtRWVgVVLLGTIALNVWLYISI 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 584 PRlgtSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSspvdptgSTNSMAIMVEYdNDT 663
Cdd:PRK10614 548 PK---TFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGS-------RVNSGMMFITL-KPL 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 664 PNFDVEADKVIKHADG--FKHPGE----WKNQDLGTGA--GNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSD 735
Cdd:PRK10614 617 SERSETAQQVIDRLRVklAKEPGAnlflMAVQDIRVGGrqSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSD 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 736 LSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKE--NGKTVDVKVKQNKQTDWSedKLNNITLKKPTGG 813
Cdd:PRK10614 697 QQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQplNQYKVVMEVDPRYTQDIS--ALEKMFVINNEGK 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 814 TIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNkdvGGTTRQVMSKIN----NLDKPNNVKVNIGGASDDINNAMTQ 889
Cdd:PRK10614 775 AIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPT---GKSLSDASAAIEramtQLGVPSTVRGSFAGTAQVFQETMNS 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 890 LAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINN 969
Cdd:PRK10614 852 QLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEA 931
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 970 EQQG-MEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTL 1048
Cdd:PRK10614 932 QRNGnLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL 1011
|
....*..
gi 686208002 1049 KKRFTKR 1055
Cdd:PRK10614 1012 RLRFSRK 1018
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
30-1045 |
4.45e-68 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 247.83 E-value: 4.45e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 30 ASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQ 109
Cdd:PRK09579 28 AWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSIISIYARIGADSDRLFTE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 110 LKKEIDKIKFK--DEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLK 187
Cdd:PRK09579 108 LLAKANEVKNQlpQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPKLATLPGMAEAEILGNQVFAMRLW 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 188 FKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNIniPLtlaggqgqsqsqsdnkqnsa 267
Cdd:PRK09579 188 LDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFAAI--PV-------------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 268 mshvnqaspqqnskasasnNISGMPTAKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTF 346
Cdd:PRK09579 246 -------------------KTSGDSRVLLGDVARVEMGaENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPEL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 347 VDE-NKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNIL 425
Cdd:PRK09579 307 ESQlPPNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 426 TLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGEnliISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFA 505
Cdd:PRK09579 387 TLLAMVLAIGLVVDDAIVVVENIHRHIEEGKSPFDAA---LEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 506 LAIAFSLLASLLVSITLVPALAATLFK-----KGVKRRNKQHQEGLGVvstTYKKVLHWSLNHKWIVIILSTLILVATIV 580
Cdd:PRK09579 464 LTLAGAVIISGIVALTLSPMMCALLLRheenpSGLAHRLDRLFERLKQ---RYQRALHGTLNTRPVVLVFAVIVLALIPV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 581 FggPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKD-VEKYLK---------QKKHVKTIQYSVGGS--SPVDPTG 648
Cdd:PRK09579 541 L--LKFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDeFTPIFKsfpeyyssfQINGFNGVQSGIGGFllKPWNERE 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 649 STNsMAIMVEYD---NDTPNFDVEadkvikhadGFKHPGEwknqdLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQ 725
Cdd:PRK09579 619 RTQ-MELLPLVQaklEEIPGLQIF---------GFNLPSL-----PGTGEGLPFQFVINTANDYESLLQVAQRVKQRAQE 683
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 726 VKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNI 805
Cdd:PRK09579 684 SGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNY 763
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 806 TLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSA--KVTNKDVGGTTRQVMSKinnlDKPNNVKVNIGGASDDI 883
Cdd:PRK09579 764 YVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAIISGfpIVSMGEAIETVQQIARE----EAPEGFAFDYAGASRQY 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 884 NNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLI 963
Cdd:PRK09579 840 VQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIV 919
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 964 DRVIN-NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIY 1042
Cdd:PRK09579 920 EFANQlRHEQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIY 999
|
...
gi 686208002 1043 EIL 1045
Cdd:PRK09579 1000 TLL 1002
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
30-1051 |
3.79e-63 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 233.18 E-value: 3.79e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 30 ASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASI-VTVEYENNTDMDKAEE 108
Cdd:PRK10555 26 AIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGTGQAsVTLSFKAGTDPDEAVQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 109 QLKKEIDKI--KFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKK--VTKVLNEQLIPKLQTVDGVQNAQLNG-QTNRE 183
Cdd:PRK10555 106 QVQNQLQSAmrKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKqdIADYVASNIQDPLSRVNGVGDIDAYGsQYSMR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 184 ITLKfkQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDKDKsivVDGQyqSVDAFKNinipltlaggqgqsqsqsdnk 263
Cdd:PRK10555 186 IWLD--PAKLNSFQMTTKDVTDAIESQNAQIAVG--QLGGTPS---VDKQ--ALNATIN--------------------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 264 qnsAMSHVNqaSPQQNSKASASNNISGmPTAKLGDLADITVGDVR-TSISKTNGKDAVNLQITKAQDANTVQVAKDVQRK 342
Cdd:PRK10555 236 ---AQSLLQ--TPEQFRDITLRVNQDG-SEVTLGDVATVELGAEKyDYLSRFNGKPASGLGVKLASGANEMATAKLVLNR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 343 IDT---FVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSD 419
Cdd:PRK10555 310 LDElaqYFPHGLEYKVA--YETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFG 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 420 VSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGE 499
Cdd:PRK10555 388 YSINTLTMFAMVLAIGLLVDDAIVVVENVERIM--SEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGA 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 500 MFRPFALAIAFSLLASLLVSITLVPALAATLFK---KG---------------VKRRNKQHQEGLGvvsttykKVLHWSL 561
Cdd:PRK10555 466 IYRQFSITIVSAMVLSVLVAMILTPALCATLLKplkKGehhgqkgffgwfnrmFNRNAERYEKGVA-------KILHRSL 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 562 nhKWIVIILstlILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYL--KQKKHVKTIqYSVG 639
Cdd:PRK10555 539 --RWILIYV---LLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYftHEKDNVMSV-FATV 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 640 GSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHA-DGFKHPGEWKN--------QDLGTGAGNKSVEVTVKGPSMD 710
Cdd:PRK10555 613 GSGPGGNGQNVARMFIRLKDWDERDSKTGTSFAIIERAtKAFNKIKEARViassppaiSGLGSSAGFDMELQDHAGAGHD 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 711 AIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVK 790
Cdd:PRK10555 693 ALMAARNQLLALAAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQ 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 791 QNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNlDKPN 870
Cdd:PRK10555 773 AAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVK-QLPN 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 871 NVKVNIGGAS--DDINNAMTQLAFAM--------LAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIALLITGETI 940
Cdd:PRK10555 852 GFGLEWTAMSyqERLSGAQAPALYAIsllvvflcLAAL----------YESWSVPFSVMLVVPLGVIGALLATWMRGLEN 921
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 941 SVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLA 1020
Cdd:PRK10555 922 DVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVG 1001
|
1050 1060 1070
....*....|....*....|....*....|....
gi 686208002 1021 ATVIGGLISSTLLTLVVVPVIYEIL---FTLKKR 1051
Cdd:PRK10555 1002 TGVMGGMISATILAIFFVPLFFVLVrrrFPLKPR 1035
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
40-1055 |
6.87e-55 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 207.78 E-value: 6.87e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 40 PNVQNPVISVTTTMPGATPQSTQDEISSKID---NQVRSLAYVKnvKTQSIQNASIvTVEYENNTDMDKAEEQLKKEIDK 116
Cdd:PRK09577 36 PDIAPPVVSIYATYPGASAQVVEESVTALIEremNGAPGLLYTS--ATSSAGQASL-SLTFKQGVNADLAAVEVQNRLKT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 117 IkfkdEVGQPE-LRRN------SMDAFPvLAYSFSNKENDLKKVT--KVLNEQLIPKLQTVDGVQNAQLNGQtnrEITLK 187
Cdd:PRK09577 113 V----EARLPEpVRRDgiqvekAADNIQ-LIVSLTSDDGRLTGVElgEYASANVLQALRRVEGVGKVQFWGA---EYAMR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 188 FKQN--ELEKYGLTADDVENYLKTATRTTPLGlfQFGDK--------DKSIVVDGQYQSVDAFKNINIpltlaggqgqsq 257
Cdd:PRK09577 185 IWPDpvKLAALGLTASDIASAVRAHNARVTIG--DIGRSavpdsapiAATVFADAPLKTPEDFGAIAL------------ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 258 sqsdnkqnsamshvnqaspqqNSKASASnnisgmpTAKLGDLADITVGDVRTS-ISKTNGKDAVNLQITKAQDANTVQVA 336
Cdd:PRK09577 251 ---------------------RARADGS-------ALYLRDVARIEFGGNDYNyPSYVNGKTATGMGIKLAPGSNAVATE 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 337 KDVQRKID---TFVDENKDFNVTktMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALI 413
Cdd:PRK09577 303 KRVRATMDelsRYFPPGVKYQIP--YETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFG 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 414 ALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFV 493
Cdd:PRK09577 381 VMLAAGFSINVLTMFGMVLAIGILVDDAIVVVENVERLMV--EEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFF 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 494 SGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATL-----------------FKKGVKRRNKQHQEGLGVVsttYKKV 556
Cdd:PRK09577 459 GGAVGNIYRQFALSLAVSIGFSAFLALSLTPALCATLlkpvdgdhhekrgffgwFNRFVARSTQRYATRVGAI---LKRP 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 557 LHWslnhkwiVIILSTLILVATIVFggPRLGTSFISAGDD-KFLAITYTPKpGETEQAVLNHAKDVEKYLKQKKHVKTIq 635
Cdd:PRK09577 536 LRW-------LVVYGALTAAAALLF--TRLPTAFLPDEDQgNFMVMVIRPQ-GTPLAETMQSVREVESYLRRHEPVAYT- 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 636 YSVGGSSpVDPTGSTNSMaIMVEYDNDTPNFDVEA------DKVIKHADGFKHPGEWKNQ-----DLGTGAGNKSVEVTV 704
Cdd:PRK09577 605 FALGGFN-LYGEGPNGGM-IFVTLKDWKERKAARDhvqaivARINERFAGTPNTTVFAMNspalpDLGSTSGFDFRLQDR 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 705 KGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKT 784
Cdd:PRK09577 683 GGLGYAAFVAAREQLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQV 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 785 VDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAkvtNKDVGGTTRQVMSKIN 864
Cdd:PRK09577 763 RRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTING---SAAPGHSSGEAMAAIE 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 865 NLDK--PNNVKVNIGGAS--DDINNAMTQLAFAM--------LAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIA 932
Cdd:PRK09577 840 RIAAtlPAGIGYAWSGQSfeERLSGAQAPMLFALsvlvvflaLAAL----------YESWSIPFAVMLVVPLGVIGAVLG 909
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 933 LLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSS 1012
Cdd:PRK09577 910 VTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAA 989
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|...
gi 686208002 1013 ILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR 1055
Cdd:PRK09577 990 SGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVGRLFDVGPRR 1032
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
33-1055 |
6.49e-54 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 205.14 E-value: 6.49e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 33 KLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKID---NQVRSLAYVKNVKTQSiqNASIVTVEYENNTDMDKAEEQ 109
Cdd:PRK15127 29 KLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEqnmNGIDNLMYMSSNSDST--GTVQITLTFESGTDADIAQVQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 110 LKKEIDKIK--FKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKK--VTKVLNEQLIPKLQTVDGVQNAQLNGqTNREIT 185
Cdd:PRK15127 107 VQNKLQLAMplLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQedISDYVAANMKDPISRTSGVGDVQLFG-SQYAMR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 186 LKFKQNELEKYGLTADDVENYLKTATRTTPLGlfQFGDK--------DKSIVVDGQYQSVDAFKNInipltlaggqgqsq 257
Cdd:PRK15127 186 IWMNPNELNKFQLTPVDVINAIKAQNAQVAAG--QLGGTppvkgqqlNASIIAQTRLTSTEEFGKI-------------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 258 sqsdnkqnsaMSHVNQASPQqnskasasnnisgmptAKLGDLADITVG-DVRTSISKTNGKDAVNLQITKAQDAN---TV 333
Cdd:PRK15127 250 ----------LLKVNQDGSR----------------VRLRDVAKIELGgENYDIIAEFNGQPASGLGIKLATGANaldTA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 334 QVAKDVQRKIDTFVDENkdFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALI 413
Cdd:PRK15127 304 AAIRAELAKMEPFFPSG--LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 414 ALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLtdSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFV 493
Cdd:PRK15127 382 VLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM--AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFF 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 494 SGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEG-LGVVSTTYKKVLHW---SLNHkwivII 569
Cdd:PRK15127 460 GGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGfFGWFNRMFEKSTHHytdSVGN----IL 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 570 LST-------LILVATIVFGGPRLGTSFISAGDDK-FLAITYTPKPGETE--QAVLNHAKDVekYL-KQKKHVKTIqYSV 638
Cdd:PRK15127 536 RSTgrylvlyLIIVVGMAYLFVRLPSSFLPDEDQGvFLTMVQLPAGATQErtQKVLNEVTDY--YLtKEKNNVESV-FAV 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 639 GGSSpVDPTGSTNSMAIMVEYD-NDTPNFDVEADKVIKHADG------------FKHPGewkNQDLGTGAGNKSVEVTVK 705
Cdd:PRK15127 613 NGFG-FAGRGQNTGIAFVSLKDwADRPGEENKVEAITMRATRafsqikdamvfaFNLPA---IVELGTATGFDFELIDQA 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 706 GPSMDAIKSTVKDI-EQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKT 784
Cdd:PRK15127 689 GLGHEKLTQARNQLlGEAAKHPDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRV 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 785 VDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKIN 864
Cdd:PRK15127 769 KKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELA 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 865 NlDKPNNVKVNIGGASDDINNAMTQ----------LAFAMLAAIiivylilvitFKGGLAPFTILFSLPFTVIGVIIALL 934
Cdd:PRK15127 849 S-KLPTGVGYDWTGMSYQERLSGNQapalyaisliVVFLCLAAL----------YESWSIPFSVMLVVPLGVIGALLAAT 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 935 ITGETISVPSLIGMLMLIGIVVTNAIVLIDRVIN-NEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSI 1013
Cdd:PRK15127 918 FRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDlMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGS 997
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|..
gi 686208002 1014 LISKGLAATVIGGLISSTLLTLVVVPVIYEIlftLKKRFTKR 1055
Cdd:PRK15127 998 GAQNAVGTGVMGGMVTATVLAIFFVPVFFVV---VRRRFSRK 1036
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
329-1055 |
1.25e-29 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 126.90 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 329 DANTVQVAKDVQRKIDTFVDENKDFNVT----KTMDTAKPVEKSLYTMVekaSLGTIVAIIVILLFLRNIRTTAISIISI 404
Cdd:COG1033 176 DLDRKEVVAEIRAIIAKYEDPGVEVYLTgfpvLRGDIAEAIQSDLAIFF---PLALLLILLLLFLFFRSLRGVLLPLLVV 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 405 PLSLLMALIALKLSDVSLNILT--LGALTVAIGrvIDDSIVVVeNIYRrltdsEEQLKGEN---LIISATTEVFKPIMSS 479
Cdd:COG1033 253 LLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIG--IDYGIHLL-NRYR-----EERRKGLDkreALREALRKLGPPVLLT 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 480 TLVTIIVFLPLVFvSGSvgEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVsttYKKVLHW 559
Cdd:COG1033 325 SLTTAIGFLSLLF-SDI--PPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGRL---LAKLARF 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 560 SLNHKWIVIILSTLILVATIvFGGPRLGTSFisagddkflaitytpkpgeteqavlnhakDVEKYLKQK----KHVKTIQ 635
Cdd:COG1033 399 VLRRPKVILVVALVLAVVSL-YGISRLKVEY-----------------------------DFEDYLPEDspirQDLDFIE 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 636 YSVGGSSPVDptgstnsmaIMVEYDNDTPNFDVEADKVIkhadgfkhpgewknqdlgtgagnksvevtvkgpsmdaikst 715
Cdd:COG1033 449 ENFGGSDPLE---------VVVDTGEPDGLKDPEVLKEI----------------------------------------- 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 716 vKDIEQKMKQVKGLANVKSdLSQTYDQYEIKVDQNKAAENGISASQlamhlnENLPEKTVTTVKENGKTVDVKVKQNKQt 795
Cdd:COG1033 479 -DRLQDYLESLPEVGKVLS-LADLVKELNQALNEGDPKYYALPESR------ELLAQLLLLLSSPPGDDLSRFVDEDYS- 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 796 dwsedklnnitlkkptggtiklgdiatlvktttpskltqeqgdyATTVSAKVtnKDVGGTT-----RQVMSKINNLDKPN 870
Cdd:COG1033 550 --------------------------------------------AARVTVRL--KDLDSEEikalvEEVRAFLAENFPPD 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 871 NVKVNIGGAS---DDINNAMTQ-----------LAFAMLAAiiivylilviTFKGGLAPFTILFSLPFTVIGVIIALLIT 936
Cdd:COG1033 584 GVEVTLTGSAvlfAAINESVIEsqirslllallLIFLLLLL----------AFRSLRLGLISLIPNLLPILLTFGLMGLL 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 937 GETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFgqdSSILIS 1016
Cdd:COG1033 654 GIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF---SSFPPL 730
|
730 740 750
....*....|....*....|....*....|....*....
gi 686208002 1017 KGLAATVIGGLISSTLLTLVVVPViyeILFTLKKRFTKR 1055
Cdd:COG1033 731 ADFGLLLALGLLVALLAALLLLPA---LLLLLDPRIAKK 766
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-526 |
1.61e-27 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 120.59 E-value: 1.61e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 3 KKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNV 82
Cdd:COG0841 516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 83 KT-------QSIQNASIVTVEY----ENNTDMDKAEEQLKKEIDKIK-FKDEVGQPELRRNSMDAfpvlAYSFSNKENDL 150
Cdd:COG0841 596 FSvvgfsggGSGSNSGTIFVTLkpwdERDRSADEIIARLREKLAKIPgARVFVFQPPAGGLGSGA----PIEVQLQGDDL 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 151 KKVTKVLnEQLIPKLQTVDGVQNAQLNGQTNR-EITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIV 229
Cdd:COG0841 672 EELAAAA-EKLLAALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVR 750
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 230 V--DGQY-QSVDAFKNINIPltlaggqgqsqsqsdnkqnsamshvnqaspqqnskasasnNISGMPTAkLGDLADITVGD 306
Cdd:COG0841 751 VqaPEEDrNSPEDLENLYVR----------------------------------------TPDGEMVP-LSSVATIEEGT 789
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 307 VRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKID----------TFVDENKDFNvtKTMDTakpvekslytmvekA 376
Cdd:COG0841 790 GPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAelklppgvsiEFTGQAEEEQ--ESFSS--------------L 853
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 377 SLGTIVAIIVILLFL----RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIyrrl 452
Cdd:COG0841 854 GLAFLLALLLVYLVLaaqfESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA---- 929
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686208002 453 tdSEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPAL 526
Cdd:COG0841 930 --NQLREEGMSLreaILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVL 1004
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
320-538 |
3.90e-20 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 96.47 E-value: 3.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 320 VNLQITKAQDANTVQVAKDVQRKIDT-FVDENKDFNVT-------KTMDTakpVEKSLYTMvekaSLGTIVAIIVILLFL 391
Cdd:COG1033 553 VTVRLKDLDSEEIKALVEEVRAFLAEnFPPDGVEVTLTgsavlfaAINES---VIESQIRS----LLLALLLIFLLLLLA 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 392 -RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENiYRrltdsEEQLKGENL---IIS 467
Cdd:COG1033 626 fRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSR-YR-----EERRKGGDLeeaIRR 699
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686208002 468 ATTEVFKPIMSSTLVTIIVFLPLVFvsgSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRR 538
Cdd:COG1033 700 ALRTTGKAILFTSLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
99-540 |
2.45e-15 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 81.23 E-value: 2.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 99 NNTDMD---KAEEQLKKEIDKIKFKDEVgqpelrRNSMDAFPVLAYSFS------NKE---------------NDLKkvt 154
Cdd:COG3696 615 NMSETFvilKPRSEWRSGRTKEELIAEM------REALEQIPGVNFNFSqpiqmrVDEllsgvradvavkifgDDLD--- 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 155 kVLN---EQLIPKLQTVDGVQNAQLNGQTN-REITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVV 230
Cdd:COG3696 686 -VLRrlaEQIEAVLKTVPGAADVQVERVTGlPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVV 764
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 231 --DGQY-QSVDAFKNINIPLtlaggqgqsqsqsdnkqnsamshvnqaspqqnskasasnnisgmPTAK---LGDLADITV 304
Cdd:COG3696 765 rlPEELrDDPEAIRNLPIPT--------------------------------------------PSGAqvpLSQVADIEV 800
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 305 GDVRTSISKTNGKDAVnlqitkaqdanTVQVakDVQ-RKIDTFVDENKdfnvtktmdtAKpVEKSL-----YTMV----- 373
Cdd:COG3696 801 VEGPNQISRENGRRRI-----------VVQA--NVRgRDLGSFVAEAQ----------AK-VAEQVklppgYYIEwggqf 856
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 374 ---EKAS--LGTIV----AIIVILLFL--RNIRTTAISIISIPLSLLMALIALKLSDVSLNIltlgalTVAIGRV----- 437
Cdd:COG3696 857 enlQRATarLAIVVplalLLIFLLLYLafGSVRDALLILLNVPFALIGGVLALWLRGMPLSV------SAGVGFIalfgv 930
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 438 -IDDSIVVVENIYRRLtdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFvSGSVG-EMFRPFALAIAFSLLAS 515
Cdd:COG3696 931 aVLNGVVLVSYINQLR---AEGLDLREAIIEGALERLRPVLMTALVAALGLLPMAL-STGPGsEVQRPLATVVIGGLITS 1006
|
490 500
....*....|....*....|....*
gi 686208002 516 LLVSITLVPALAATLFKKGVKRRNK 540
Cdd:COG3696 1007 TLLTLLVLPALYLLFGRRRLRRAAA 1031
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
4-541 |
6.81e-15 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 79.80 E-value: 6.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 4 KLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISV-TTTMPGATP-QSTqdEISSKIDNQVRSLAYVKN 81
Cdd:TIGR00914 528 PLLERVLAWPAVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYqALRIPGTSLaQSV--AMQQTLEKLIKSFPEVAR 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 82 V--KTQSIQ--------NASIVTVEYE--------NNTDMDKAEEQLKKEIDKIKFKDEVGQP-ELRRNSMDA---FPVL 139
Cdd:TIGR00914 606 VfaKTGTAEiatdpmppNASDTYIILKpesqwpegKKTKEDLIEEIQEATVRIPGNNYEFTQPiQMRFNELISgvrSDVA 685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 140 AYSFSNKENDLKKVTKVLNEQLipklQTVDGVQNA---QLNGqtNREITLKFKQNELEKYGLTADDVENYLKTATRTTPL 216
Cdd:TIGR00914 686 VKVFGDDLDDLDATAEKISAVL----KGVPGAADVkveQTTG--LPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMS 759
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 217 GLFQFGDKDKSIVV---DGQYQSVDAFKNINIPLtlaggqgqsqsqsdnkqnsamshvnqasPQQNSKASASnnisgmpt 293
Cdd:TIGR00914 760 GETFEGDRRFDIVIrlpESLRESPQALRQLPIPL----------------------------PLSEDARKQF-------- 803
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 294 AKLGDLADITVGDVRTSISKTNGKDAVNLQITkAQDANTVQVAKDVQRKIDTFVDENKDFNVT--KTMDTAKPVEKSLYT 371
Cdd:TIGR00914 804 IPLSDVADLRVSPGPNQISRENGKRRVVVSAN-VRGRDLGSFVDDAKKAIAEQVKLPPGYWITwgGQFEQLQSATKRLQI 882
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 372 MVEKASLgtivaIIVILLFL--RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIy 449
Cdd:TIGR00914 883 VVPVTLL-----LIFVLLYAafGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFI- 956
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 450 RRLTDSEEQLKgENLIISATTEVfKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAAT 529
Cdd:TIGR00914 957 RKLLEEGPSLD-EAVYEGALTRV-RPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRL 1034
|
570
....*....|..
gi 686208002 530 LFKKGVKRRNKQ 541
Cdd:TIGR00914 1035 VHRRRHKGRKEH 1046
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
320-593 |
1.77e-13 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 74.80 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 320 VNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLF-LRNIRTTA 398
Cdd:COG2409 118 VTVTLDGDAGDEAAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLvFRSLVAAL 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 399 ISIISIPLSLL--MALIAL-----KLSDVSLNILTLgaLTVAIGrvIDDSIVVVeNIYRrltdsEEQLKGENL---IISA 468
Cdd:COG2409 198 LPLLTAGLAVGvaLGLLALlaaftDVSSFAPNLLTM--LGLGVG--IDYALFLV-SRYR-----EELRAGEDReeaVARA 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 469 TTEVFKPIMSSTLVTIIVFLPLVFVSGSvgeMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGV 548
Cdd:COG2409 268 VATAGRAVLFSGLTVAIALLGLLLAGLP---FLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRVFWPRRPRRRRAAAP 344
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 686208002 549 VSTTYKKVLHWSLNHKWIVIILSTLILVA-TIVFGGPRLGTSFISA 593
Cdd:COG2409 345 ESGFWRRLARAVVRRPVPVLVAAVAVLLAlALPALGLRLGLPDADS 390
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
4-526 |
3.66e-13 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 74.25 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 4 KLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVK 83
Cdd:pfam00873 518 KLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVF 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 84 TQ---------SIQNASIVTVEYENNTDMDKAE-------EQLKKEIDKIKFKDEVGQ--PELRRNSMDAFPVLAYSFSN 145
Cdd:pfam00873 598 AVtgfafsgdnNGPNSGDAFISLKPWKERPGPEksvqaliERLRKALKQIPGANVFLFqpIQLRGLGTISGFRSDLQVKI 677
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 146 KENDLKKVTKvLNEQLIPKLQTVDGVQNAQLNGQTN-REITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDK 224
Cdd:pfam00873 678 FGDDLDALDE-ARNQILAALAQLPGLSDVRSDGQEDqPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGR 756
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 225 DKSIVV--DGQY-QSVDAFKNINIPltlaggqgqsqsqsdnkqnsamshvnqaspqqnskasasNNISGMptAKLGDLAD 301
Cdd:pfam00873 757 VYDVVVqlPEDFrSSPEDIGQLYVR---------------------------------------NPYGKM--IPLSAFAK 795
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 302 ITVGDVRTSISKTNGKDAVNLQITKAQDANTVQvAKDVQRKIDTFVDENKDFNVTKTMDTAkpVEKSLYTMVEKASLGTI 381
Cdd:pfam00873 796 IEWGYGPPSINRYNGFRSIVISGNVAAGDSLGD-AMEAMAQIAKQVKLPPGYGYTWTGQFE--QEQLAGNSLPILIALAL 872
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 382 VAIIVILLFL-RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIyrrltDSEEQLK 460
Cdd:pfam00873 873 LVVFLVLAALyESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFA-----NELREQE 947
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686208002 461 GENL---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPAL 526
Cdd:pfam00873 948 GKSLeeaILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVF 1016
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
365-528 |
2.78e-10 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 64.63 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 365 VEKSLYTMVE---KASLGTIVAIIVILLF-LRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDD 440
Cdd:TIGR03480 703 ILESGDTVVGaflQAFIYALVAITVLLLLtLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDF 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 441 SIVVVENiYRRLTDSeeqlkgENLIISATTevfKPIMSSTLVTIIVFLPLVFVS----GSVGEMfrpFALAIAFSLLASL 516
Cdd:TIGR03480 783 GIYMVHR-WRNGVDS------GNLLQSSTA---RAVFFSALTTATAFGSLAVSShpgtASMGIL---LSLGLGLTLLCTL 849
|
170
....*....|..
gi 686208002 517 LVsitlVPALAA 528
Cdd:TIGR03480 850 IF----LPALLG 857
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
375-530 |
1.96e-09 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 60.38 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 375 KASLGTIVAIIVILLFL-RNIRTTAISIISIPLSLLMAL---------IALKLSDVSLNILTlgALTVAIGrvIDDSIVV 444
Cdd:pfam03176 146 LIEAVTLVVIFIILLIVyRSVVAALLPLLTVGLSLGAAQglvailahiLGIGLSTFALNLLV--VLLIAVG--TDYALFL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 445 VENiYRrltdsEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFvsgSVGEMFRPFALAIAFSLLASLLVSIT 521
Cdd:pfam03176 222 VSR-YR-----EELRAGEDReeaVIRAVRGTGKVVTAAGLTVAIAMLALSF---ARLPVFAQVGPTIAIGVLVDVLAALT 292
|
....*....
gi 686208002 522 LVPALAATL 530
Cdd:pfam03176 293 LLPALLALL 301
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
266-588 |
1.81e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 58.70 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 266 SAMSHVNQASPQQNSKASASNNISGMPTAKLGDL------ADITVG---------------DVRTSISKTNGKDAVNLQI 324
Cdd:TIGR00921 98 DIMRQIPGNFPLPVTMPEVRPLMSEYPRSKEMFLskdhtvAIIIVQlksdadykqvvpiynDVERSLERTNPPSGKFLDV 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 325 TkaqdaNTVQVAKDVQRKIdtfvdeNKDFNVTktmdtakpvekslytmvekASLGTIVAIIVILLFLRNIRTTAISIISI 404
Cdd:TIGR00921 178 T-----GSPAINYDIEREF------GKDMGTT-------------------MAISGILVVLVLLLDFKRWWRPLLPLVII 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 405 PLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYrrltdsEEQLKGENL---IISATTEVFKPIMSSTL 481
Cdd:TIGR00921 228 LFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE------EERDIGRAKgeaIVTAVRRTGRAVLIALL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 482 VTIIVFLPLvfvSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATL--FKKGVKRRNKQHQEGLGVVSTTYKKVLHW 559
Cdd:TIGR00921 302 TTSAGFAAL---ALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIdiGREKVKKEIIAIGGKSSEIEEELSKVLSI 378
|
330 340
....*....|....*....|....*....
gi 686208002 560 SLNHKWiVIILSTLILVATIVFGGPRLGT 588
Cdd:TIGR00921 379 TVRHPV-PALVAALIITGLGLYGAAGIKP 406
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
373-585 |
3.04e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.39 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 373 VEKASLGTIVAIIVILLFL-RNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSI-VVVENIYR 450
Cdd:COG4258 251 ISTIGLISLLGILLLLLLVfRSLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLGFGSSLIGVAVDYSLhYLTHRRAA 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 451 RLTDSEEQLKgenliisattEVFKPIMSSTLVTIIVFLPLVFvSGSvgEMFRPFALAIAFSLLASLLVSITLVPAlaatL 530
Cdd:COG4258 331 GEWDPRAALR----------RIWPTLLLGLLTTVLGYLALLF-SPF--PGLRQLGVFAAAGLLAAALTTLLWLPL----L 393
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 686208002 531 FKKGVKRRNKQHQEGLGVVsttykkVLHWSLNHKWIVIILSTLILVATIVFGGPR 585
Cdd:COG4258 394 LPRAAPRPPAPALALLARL------LARWPRRLRWLLALLAVLALASLLGLNRLK 442
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
378-526 |
3.23e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.38 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 378 LGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDV--SLNILTLGALTVAIGrvIDDSIVVVEniyrRLTDS 455
Cdd:TIGR00921 575 AGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIpsFLAMATTISIILGLG--MDYSIHLAE----RYFEE 648
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686208002 456 EEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFvsgSVGEMFRPFALAIAFSLLASLLVSITLVPAL 526
Cdd:TIGR00921 649 RKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLL---SHFPIMRNFGLVQGIGVLSSLTAALVVFPAL 716
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
378-525 |
5.06e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 5.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 378 LGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEE 457
Cdd:COG4258 647 LALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDKGELART 726
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686208002 458 QLkgeNLIISATTevfkpimsstlvTIIVFLPLVFVSGSVgemFRPFALAIAFSLLASLLVSITLVPA 525
Cdd:COG4258 727 LL---SILLAALT------------TLLGFGLLAFSSTPA---LRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
377-514 |
5.42e-06 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 50.60 E-value: 5.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 377 SLGTIVAIIVILLF--LRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVE--NIYRRl 452
Cdd:PRK09579 849 TFGLALAIIFLVLAaqFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEfaNQLRH- 927
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686208002 453 tdsEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSG-----------------SVGEMFRPFALAIAFSLLA 514
Cdd:PRK09579 928 ---EQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGagavsrfdiglviatgmSIGTLFTLFVLPCIYTLLA 1003
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
348-577 |
2.91e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 48.07 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 348 DENKDFNVTKTMDTAKPVE--KSLYTMVEKASLGTIVAIIVILLF-LRNIRTtaisIISIPLSLLMALI---ALKLSDV- 420
Cdd:TIGR03480 244 DEDHGVTVRLTGEVALSDEelATVSEGATVAGLLSFVLVLVLLWLaLRSPRL----VFAVLVTLIVGLIltaAFATLAVg 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 421 SLNILTLGALTVAIGRVIDDSIVVVENiYRrltdsEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPLVFVSGS- 496
Cdd:TIGR03480 320 HLNLISVAFAVLFIGLGVDFAIQFSLR-YR-----EERFRGGNHreaLSVAARRMGAALLLAALATAAGFFAFLPTDYKg 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 497 VGEMfrpfALAIAFSLLASLLVSITLVPALaATLFKKgvKRRNKqhqeglGVVSTTYKKVLHWSLNH-KWIVIIlsTLIL 575
Cdd:TIGR03480 394 VSEL----GIIAGTGMFIALFVTLTVLPAL-LRLLRP--PRRRK------PPGYATLAPLDAFLRRHrRPVLGV--TLIL 458
|
..
gi 686208002 576 VA 577
Cdd:TIGR03480 459 GI 460
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
375-520 |
3.15e-05 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 46.10 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 375 KASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVvvenIYRRLTD 454
Cdd:TIGR00916 51 IALLIGLVLVLLYMLLRYEWRGAIAAIAALVHDVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVV----IFDRIRE 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 455 SEEQLKGENL---IISATTEVFKPIMSSTLVTIIVFLPL-VFVSGSVgemfRPFALAIAFSLLASLLVSI 520
Cdd:TIGR00916 127 ELRKYKGRTFreaINLGINQTLSRIIDTNVTTLLAVLALyVFGGGAI----KGFALTLGIGVIAGTYSSI 192
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
381-592 |
9.55e-05 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 46.38 E-value: 9.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 381 IVAIIVILLF-LRNIRTT-AISIISIPLSLLMALIALklsdVSLN-ILTLG---ALTVAIGRVIDDSIVVVENIyrrltd 454
Cdd:PRK13024 273 IIGFALIFLFmLVYYGLPgLIANIALLLYIFLTLGAL----SSLGaVLTLPgiaGLVLGIGMAVDANVLIFERI------ 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 455 sEEQLKGENLIISATTEVFK----PIMSSTLVTIIV-FLPLVFVSGSVgemfRPFALAIAFSLLASLLVSITLVPALAAT 529
Cdd:PRK13024 343 -KEELRKGKSLKKAFKKGFKnafsTILDSNITTLIAaAILFFFGTGPV----KGFATTLIIGILASLFTAVFLTRLLLEL 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686208002 530 LFKKGVKRR--NKQHQEGLGVVSTTYKKVLHWSL--NHKWIVIILSTLILVATIVF--GGPRLGTSFIS 592
Cdd:PRK13024 418 LVKRGDKKPflFGVKKKKIHNINEGVTIFDRIDFvkKRKWFLIFSIVLVIAGIIIFfiFGLNLGIDFTG 486
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
855-1041 |
7.87e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 43.67 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 855 TTRQVMSKINNLDK-------PNNVKVNIGGA---SDDINNAM-TQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLP 923
Cdd:TIGR00921 149 DYKQVVPIYNDVERslertnpPSGKFLDVTGSpaiNYDIEREFgKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIIL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 924 FTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALV 1003
Cdd:TIGR00921 229 FGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFA 308
|
170 180 190
....*....|....*....|....*....|....*....
gi 686208002 1004 PLLFGQDSSIL-ISKGLAAtvigGLISSTLLTLVVVPVI 1041
Cdd:TIGR00921 309 ALALSEFPMVSeFGLGLVA----GLITAYLLTLLVLPAL 343
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
378-544 |
9.25e-04 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 43.57 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 378 LGTIVAIIVILLFLRNIRTTAISIIS-IPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVEniYRRLTDSE 456
Cdd:PRK10503 871 VAAVVAMYIVLGVLYESFIHPITILStLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMID--FALAAERE 948
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 457 EQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALaATLFKK--- 533
Cdd:PRK10503 949 QGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVI-YLLFDRlal 1027
|
170
....*....|.
gi 686208002 534 GVKRRNKQHQE 544
Cdd:PRK10503 1028 YTKSRFPRHEE 1038
|
|
| SecD_SecF |
pfam02355 |
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ... |
372-533 |
9.40e-04 |
|
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.
Pssm-ID: 280510 [Multi-domain] Cd Length: 189 Bit Score: 41.44 E-value: 9.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 372 MVEKASLGTIVAIIVIL--LFLRNIRTTAI-SIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENI 448
Cdd:pfam02355 29 LARKAVLALLFALLLILiyVGLRFEWRFALgAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSVNDTVVVFDRV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 449 YRRLTdseeQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAA 528
Cdd:pfam02355 109 RENLR----KKTRATLNEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVGVIVGTYSSIFIASPILL 184
|
....*
gi 686208002 529 TLFKK 533
Cdd:pfam02355 185 DLGER 189
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
348-518 |
2.03e-03 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 42.34 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 348 DENKDFNVTKTMDTAKPVekSLYTMVEKASLGTIVaIIVILLFlrnirttAISIISIPLslLMALIALKLSDVSLNILTL 427
Cdd:pfam02460 614 DQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIV-ITLICMF-------IVCFLFIPN--PPCVFVITLAIASIDIGVF 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686208002 428 GALT---------------VAIGRVIDDSIVVVENIYR-RLTDSEEQlkgenlIISATTEVFKPIMSSTLVTIIVFLPLV 491
Cdd:pfam02460 682 GFLSlwgvdldpismitiiMSIGFSVDFSAHIAYHFVRsRGDTPAER------VVDALEALGWPVFQGGLSTILGVLVLL 755
|
170 180
....*....|....*....|....*...
gi 686208002 492 FVSGSVGEMF-RPFALAIAFSLLASLLV 518
Cdd:pfam02460 756 FVPSYMVVVFfKTVFLVVAIGLLHGLFI 783
|
|
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