Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 685304675    9 VMPKLISFLSSLLERVSESNDLTRRVTTQSQSVSvfeGLsRPPITIQ 55
Cdd:pfam13393  32 VMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLL---GL-RADITPQ 74

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685304675   12 KLISFLSSLLERVSESNDLTRRVTTQSQS----------VSVFEGLSRPPITIQSYLERIFKYANCSPSCFVVAYVYLDR 81
Cdd:pfam08613   2 KLIQMISGELDRLIANNDGTATASSDAQSplepsqlqspELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685304675   82 FTHR--QPSLPINSFNVHRLLITSVMVSAKFLDDRYYNNAYYAKVGGISTKEMNLLELDFLFGLGFDL 147
Cdd:pfam08613  82 LVKRcdSEAFVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAKVGGISLHELNHLEIDFLFLVDFDL 149

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685304675  50 PPITIQSYLERIFKYANCSPSCFVVAYVYLDRFTHRQPSLPINSFNVHRLLITSVMVSAKFLDDRYYNNAYYAKVGGIST 129
Cdd:cd20558    1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATINGFVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYAKVGGVSV 80

                         90       100
                 ....*....|....*....|.
gi 685304675 130 KEMNLLELDFLFGLGFDLNVT 150
Cdd:cd20558   81 SELNKLELEFLFLLDFDLHVS 101

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685304675  56 SYLERIFKYANCSPSCFVVAYVYLDRFTHRQPSLPINS-FNVHRLLITSVMVSAKFLDDRYYNNAYYAKVGGISTKEMNL 134
Cdd:cd20557    4 SFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGQeGSPYRLFLVALMLASKYLDDESYSNKSWAEISGLPVRELNA 83

                         90
                 ....*....|.
gi 685304675 135 LELDFLFGLGF 145
Cdd:cd20557   84 MEREFLEALDW 94

cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685304675  54 IQSYLERIFKYANCSPSCFVVAYVYLDRFTHRQPsLPINSFNVHRLLITSVMVSAKFLDDRYYNNAYYAKV-GGISTKEM 132
Cdd:cd20540    6 IYRFVLTLFSAAQLTAECAIVTLIYIERLIEYAE-IDLHPSNWRRIVLGALLLASKVWDDQAVWNVDFAKIlPILTVEDL 84

                         90
                 ....*....|...
gi 685304675 133 NLLELDFLFGLGF 145
Cdd:cd20540   85 NRLERSFLELLQF 97

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 685304675    9 VMPKLISFLSSLLERVSESNDLTRRVTTQSQSVSvfeGLsRPPITIQ 55
Cdd:pfam13393  32 VMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLL---GL-RADITPQ 74