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Conserved domains on  [gi|6831692|sp|O95988|]
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RecName: Full=T-cell leukemia/lymphoma protein 1B; AltName: Full=Oncogene TCL-1B; Short=Oncogene TCL1B; AltName: Full=SYN-1; AltName: Full=Syncytiotrophoblast-specific protein; AltName: Full=TCL1/MTCP1-like protein 1

Protein Classification

TCL1_MTCP1 domain-containing protein( domain architecture ID 10486444)

TCL1_MTCP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-124 2.59e-61

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


:

Pssm-ID: 460358  Cd Length: 118  Bit Score: 183.75  E-value: 2.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6831692      1 MASEAS-VRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWarasqgsRYEPSITVHLWQMAVHTRELLSSGQM 79
Cdd:pfam01840   1 MAEEASfPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGW-------RIETQVTVHLWQMDVPPGEPMSPSQL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6831692     80 PFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQP 124
Cdd:pfam01840  74 TPSELPLMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-124 2.59e-61

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 183.75  E-value: 2.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6831692      1 MASEAS-VRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWarasqgsRYEPSITVHLWQMAVHTRELLSSGQM 79
Cdd:pfam01840   1 MAEEASfPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGW-------RIETQVTVHLWQMDVPPGEPMSPSQL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6831692     80 PFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQP 124
Cdd:pfam01840  74 TPSELPLMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Name Accession Description Interval E-value
TCL1_MTCP1 pfam01840
TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell ...
 1-124 2.59e-61

TCL1/MTCP1 family; Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.


Pssm-ID: 460358  Cd Length: 118  Bit Score: 183.75  E-value: 2.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6831692      1 MASEAS-VRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWarasqgsRYEPSITVHLWQMAVHTRELLSSGQM 79
Cdd:pfam01840   1 MAEEASfPHLPSPPDRLWIWRPGIYEDENGRTWLPVVVETSGSSRGW-------RIETQVTVHLWQMDVPPGEPMSPSQL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6831692     80 PFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQP 124
Cdd:pfam01840  74 TPSELPLMWQLYPGNRYRASDSRFWRIVDHIQIDGTEQLILELMP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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