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Conserved domains on  [gi|68215224|ref|NP_003956|]
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C-C chemokine receptor-like 2 isoform 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606903)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
39-311 1.46e-168

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


:

Pssm-ID: 320299  Cd Length: 279  Bit Score: 470.47  E-value: 1.46e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFV 112
Cdd:cd15171   1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAwhggslGNPTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPAD 192
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDC 272
Cdd:cd15171 161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 273 KSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15171 241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
 
Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
39-311 1.46e-168

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 470.47  E-value: 1.46e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFV 112
Cdd:cd15171   1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAwhggslGNPTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPAD 192
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDC 272
Cdd:cd15171 161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 273 KSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15171 241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
22-321 3.77e-44

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 154.55  E-value: 3.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   22 SDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKgLKRVENIYLLNLAVSNLCFLLTLPF-------- 93
Cdd:PHA03087  24 DEDYADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFqiyyyilf 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   94 -WAHagGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLPEFVVYKP 172
Cdd:PHA03087 103 qWSF--GEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNK-INTVKYGYIVSLVIWIISIIETTPILFVYTT 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  173 QMEDQKYKCAfsrtPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMR---KTLRFREQRYSLFKLVFAIMVVFLL 249
Cdd:PHA03087 180 KKDHETLICC----MFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILitlKGINKSKKNKKAIKLVLIIVILFVI 255
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68215224  250 MWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNT 321
Cdd:PHA03087 256 FWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTS 327
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
56-300 3.40e-43

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 149.76  E-value: 3.40e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224    56 NLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAH--------AGGDPMCKILIGLYFVGLYSETFFNCLLTV 126
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVyylnhgdwPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   127 QRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVvykpqMEDQKYKCAFSRTP--FLPADETFWKHFLTLKM 204
Cdd:pfam00001  82 DRYLA-IVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLL-----FGWTLTVPEGNVTVcfIDFPEDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   205 NISVLVLPLFIFTFLYVQMRKTLR----------FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKehfslSDCKS 274
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRksaskqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA-----LDCEL 230
                         250       260
                  ....*....|....*....|....*.
gi 68215224   275 SYNLDKSVHITKLIATTHCCINPLLY 300
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
39-311 1.46e-168

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 470.47  E-value: 1.46e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFV 112
Cdd:cd15171   1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAwhggslGNPTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPAD 192
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDC 272
Cdd:cd15171 161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 273 KSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15171 241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
39-311 1.28e-88

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 267.39  E-value: 1.28e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFV 112
Cdd:cd15184   1 RLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAanewvfGNAMCKLLTGLYHI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHkGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpFLPAD 192
Cdd:cd15184  81 GFFSGIFFIILLTIDRYLAIVH-AVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPH---FPPSQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL---RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd15184 157 YQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTLlrcRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 270 SDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15184 237 NNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
39-311 6.99e-77

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 237.42  E-value: 6.99e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH-------AGGDPMCKILIGLYF 111
Cdd:cd15185   1 QFLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHyvrwnnwVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSAR-RRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLP 190
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHA--VFALRaRTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLC----SPLYP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETF-WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF--REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15185 155 EDTEDsWKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRcpSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 268 SLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15185 235 FETDCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
39-311 6.10e-75

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 232.49  E-value: 6.10e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFV 112
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAadgwvfGSFLCKLVSALYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpFLPAD 192
Cdd:cd14984  81 NFYSGILFLACISIDRYLAIVHAVSALRA-RTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYD---YPEDT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF--REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKE-HFSL 269
Cdd:cd14984 157 ATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRarNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLlGIIS 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 270 SDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14984 237 RSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
39-311 3.69e-70

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 220.13  E-value: 3.69e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYF 111
Cdd:cd15183   1 TLLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKlkddwifGDAMCKFLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSAR-RRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLP 190
Cdd:cd15183  81 LGLYSEIFFIILLTIDRYLAIVHA--VFALRaRTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTC----SAHFP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETF-WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR--EQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15183 155 RKSLIrWKRFQALKLNLLGLILPLLVMIICYTGIINILLRRpnEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 268 SLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15183 235 FTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
40-311 2.41e-59

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 192.32  E-value: 2.41e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVG 113
Cdd:cd15187   2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLldqwvfGNAMCKIVSGAYYIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHkGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLPADE 193
Cdd:cd15187  82 FYSSMFFITLMSIDRYLAIVH-AVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQC----IPFYPGQG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR--FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSD 271
Cdd:cd15187 157 NSWKVFTNFEVNILGLLIPFSILIFCYHNILRNLRrcHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIIDG 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 272 CKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15187 237 CQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 1.20e-49

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 167.15  E-value: 1.20e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWA---HAG---GDPMCKILIGLYFVG 113
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWAsyhSSGwifGEILCKAVTSIFYIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKgnfFSARR--RVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQK-YKCAFSrtpflp 190
Cdd:cd15182  82 FYSSILFLTLMTIDRYLAVVHP---LSALRsrKLRYASLVSVAVWVISILASLPELILSTVMKSDEDgSLCEYS------ 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 adETFWKHFLTLKMNISVLVlPLFIFTFLYVQMRKTL-RFR-EQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFS 268
Cdd:cd15182 153 --SIKWKLGYYYQQNLFFLI-PLGIIVYCYVRILQTLmRTRtMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTI 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 269 LSdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15182 230 PI-CECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
40-311 1.33e-47

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 161.92  E-value: 1.33e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH------AGGDPMCKILIGLYFVG 113
Cdd:cd15186   2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHylinewGLHNAMCKLTTAFFFIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSARRrVPCGIITSVLAWVTAILATLPEFVVYKPQMEDqkykCafsrTPFLPAD- 192
Cdd:cd15186  82 FFGGIFFITVISIDRYLAIVLAANSMNNRT-VQHGVTISLGVWAAAILVAVPQFMFTKMKENE----C----LGDYPEVl 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF--REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd15186 153 QEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSckNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFP 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15186 233 SCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
40-311 1.47e-45

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 156.77  E-value: 1.47e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYF 111
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTanqydwpfGAFLCKVSSYVIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPEFVVYKPQM--EDQKYKCAFSRTPf 188
Cdd:cd14985  82 VNMFASIFLLTCMSVDRYLAIVHP--VASRRLRRRrQARVTCALIWVVACLLSLPTFLLRSLQAieNLNKTACIMLYPH- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 lpadeTFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRY--------SLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd14985 159 -----EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTgkngrkrrKSLKIIFALVVAFLVCWLPFHFFKFL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14985 234 DFLAQLGAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
41-311 8.39e-45

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 154.56  E-value: 8.39e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKY-KGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVG 113
Cdd:cd15188   3 LPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVawhwvfGSFLCKFVSTLYTIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNF--FSARRRvpcGIITSVLAWVTAILATLPEFVVYKPQ-MEDQKYKCafsrTPFLP 190
Cdd:cd15188  83 FYSGIFFVSCMSLDKYLEIVHAQSPhrLRTRRK---SLLVLVAVWVLSIALSVPDMVFVQTHhTNNGVWVC----HADYG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMR---KTLRFREQRYSLfKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15188 156 GHHTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIAcvlTRLRPPGQGRAL-RFVAALVVVFFVLWFPYNLTLFLHSLQDLH 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 268 SLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15188 235 VIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
22-321 3.77e-44

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 154.55  E-value: 3.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   22 SDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKgLKRVENIYLLNLAVSNLCFLLTLPF-------- 93
Cdd:PHA03087  24 DEDYADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFqiyyyilf 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   94 -WAHagGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLPEFVVYKP 172
Cdd:PHA03087 103 qWSF--GEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNK-INTVKYGYIVSLVIWIISIIETTPILFVYTT 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  173 QMEDQKYKCAfsrtPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMR---KTLRFREQRYSLFKLVFAIMVVFLL 249
Cdd:PHA03087 180 KKDHETLICC----MFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILitlKGINKSKKNKKAIKLVLIIVILFVI 255
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68215224  250 MWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNT 321
Cdd:PHA03087 256 FWLPFNVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTS 327
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
56-300 3.40e-43

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 149.76  E-value: 3.40e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224    56 NLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAH--------AGGDPMCKILIGLYFVGLYSETFFNCLLTV 126
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVyylnhgdwPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   127 QRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVvykpqMEDQKYKCAFSRTP--FLPADETFWKHFLTLKM 204
Cdd:pfam00001  82 DRYLA-IVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLL-----FGWTLTVPEGNVTVcfIDFPEDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   205 NISVLVLPLFIFTFLYVQMRKTLR----------FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKehfslSDCKS 274
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRksaskqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA-----LDCEL 230
                         250       260
                  ....*....|....*....|....*.
gi 68215224   275 SYNLDKSVHITKLIATTHCCINPLLY 300
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
40-311 1.95e-39

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 140.60  E-value: 1.95e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVG 113
Cdd:cd15180   2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAvhgwifGTGLCKLAGAVFKIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK--CafsrTPFLPA 191
Cdd:cd15180  82 FYCGIFLLACISFDRYLSIVHAVQMYS-RKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKteC----VHNFPQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFK---LVFAIMVVFLLMWAPYNIAFFLSTFKEHFS 268
Cdd:cd15180 157 SDTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGFQKQRairVIVAVVVVFFLCWTPYNIALLVDTLIDLSV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 269 LS-DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15180 237 LDrNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
41-310 2.00e-39

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 140.29  E-value: 2.00e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGL 114
Cdd:cd15173   3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAahewifGTVMCKITNGLYTINL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLH--KGNFFSARRRVpCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYkCAFSrtpfLPAD 192
Cdd:cd15173  83 YSSMLILTCITVDRFIVIVQatKAHNCHAKKMR-WGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKI-CSMV----YPPD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETfWKHFLTLKMNISVLvLPLFIFTFLYVQMRKTLRFRE--QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLs 270
Cdd:cd15173 157 AI-EVVVNIIQMTVGFF-LPLLAMIICYSVIIKTLLHAKgfQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTD- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 271 dcksSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd15173 234 ----STNFKYAILITEAIAYLHACLNPILYAFVGVKFRKN 269
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
42-311 2.23e-38

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 137.95  E-value: 2.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGLY 115
Cdd:cd15176   4 PVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAvngwvlGTAMCKITSALYTMNFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVfLHKGNFFSARRRVpcGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsRTPFLPADETF 195
Cdd:cd15176  84 CGMQFLACISVDRYVA-ITKATSRQFTGKH--CWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRC---LPVFPPSLVTS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR--FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL-SDC 272
Cdd:cd15176 158 AKATIQILEVLLGFVLPFLVMVFCYSRVARALSrtPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLiTDC 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 273 KSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15176 238 SMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFKSHI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-303 8.61e-38

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 136.26  E-value: 8.61e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHA-------GGDPMCKILIGLYFVGLY 115
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSlllgrwwFGDALCKLLGFLQSVSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVF---LHKGNFFSARRRvpcgIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrtpFLPAD 192
Cdd:cd00637  84 ASILTLTAISVDRYLAIvhpLRYRRRFTRRRA----KLLIALIWLLSLLLALPPLLGWGVYDYGGYCCC------CLCWP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF-----------------REQRYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd00637 154 DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrrrrRRRERKVTKTLLIVVVVFLLCWLPYF 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 68215224 256 IAFFLSTFKEHFslsdcksSYNLDKSVHITKLIATTHCCINPLLYAFL 303
Cdd:cd00637 234 ILLLLDVFGPDP-------SPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
46-302 1.27e-37

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 135.86  E-value: 1.27e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWA---HAG---GDPMCKILIGLYFVGLYSETF 119
Cdd:cd15178   8 VLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAvsvVKGwifGTFMCKLVSLLQEANFYSGIL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVlaWVTAILATLPEFV---VYKPqMEDQKYKCAFSrtpFLPADETFW 196
Cdd:cd15178  88 LLACISVDRYLAIVHATRALTQKRHLVKFVCAGV--WLLSLLLSLPALLnrdAFKP-PNSGRTVCYEN---LGNESADKW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLKMNISVLVLPLFIFTFLY-VQMRKTLRFRE-QRYSLFKLVFAIMVVFLLMWAPYNIAFFLST-FKEHFSLSDCK 273
Cdd:cd15178 162 RVVLRILRHTLGFLLPLVVMLFCYgFTIKTLLQTRSfQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTlMRTKLITETCE 241
                       250       260
                ....*....|....*....|....*....
gi 68215224 274 SSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15178 242 LRNHVDVALYVTQILGFLHSCINPVLYAF 270
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
39-311 2.47e-36

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 132.39  E-value: 2.47e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLY 110
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYyylnggwwPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQMED-QKYKCaFSRTPFL 189
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRK-RYAVGVCAGVWILVLVASVPLLLLRSTIAKEnNSTTC-FEFLSEW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PAdetfwkhfLTLKMNISVLV----LPLFIFTFLYVQMRKTLRFREQRYSL-------FKLVFAIMVVFLLMWAPYNIAF 258
Cdd:cd14982 159 LA--------SAAPIVLIALVvgflIPLLIILVCYSLIIRALRRRSKQSQKsvrkrkaLRMILIVLAVFLVCFLPYHVTR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 259 FLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14982 231 ILYLLVRLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
42-311 3.42e-36

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 132.20  E-value: 3.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGLY 115
Cdd:cd15175   4 PAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAakkwvfGEEMCKAVYCLYKMSFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFFSARRR-VPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLPADET 194
Cdd:cd15175  84 SGMLLLMCISIDRYFAIVQAASAHRHRSRaVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC----SIFTNNKQT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FwkhflTLKMNISVLVL----PLFIFTFLYVQMRKTLRFRE--QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFS 268
Cdd:cd15175 160 L-----SVKIQISQMVLgflvPLVVMSFCYSVIIKTLLQARnfEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKG 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 269 -LSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15175 235 nTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
42-311 5.57e-36

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 131.41  E-value: 5.57e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGLY 115
Cdd:cd15174   4 PPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAAssgwvfGTFLCKVVNSMYKINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGN-FFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpfLPADET 194
Cdd:cd15174  84 SCMLLLTCISVDRYIAIVQATKaHNSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMV----YPSNES 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWKHFLTLKMNISV-LVLPLFIFTFLYVQMRKTL--RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFK-EHFSLS 270
Cdd:cd15174 160 NRFKVAVLALKVTVgFFLPFVVMVICYTLIIHTLlqAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINaYNITIT 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15174 240 DCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
41-303 3.88e-35

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 129.48  E-value: 3.88e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGL 114
Cdd:cd15181   3 IPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESiagwvfGTFLCKLVGAIHKLNF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKGNFFSARR----RVPCGIItsvlaWVTAILATLPEFVVYKPQMEDQ--KYKCAFSRTPF 188
Cdd:cd15181  83 YCSSLLLACISVDRYLAIVHAIHSYRHRRlrsvHLTCGSI-----WLVCFLLSLPNLVFLEVETSTNanRTSCSFHQYGI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFWKHFLTlkmNISVLVLPLFIFTFLYVQMRKTLR---FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTF-K 264
Cdd:cd15181 158 HESNWWLTSRFLY---HVVGFFLPLLIMGYCYATIVVTLCqssRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLdD 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 265 EHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFL 303
Cdd:cd15181 235 LKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFI 273
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-311 4.96e-35

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 129.09  E-value: 4.96e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYF 111
Cdd:cd15192   2 MIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTameyhwpfGNFLCKIASALVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLP-----EFVVYKPQmedQKYKCAFsrt 186
Cdd:cd15192  82 FNLYASVFLLTCLSIDRYLAIVHPMKSRL-RRTLVVARVTCIVIWLLAGVASLPaiihrDVFFIENT---NITVCAF--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 pFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL-------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15192 155 -HYPSQNSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALkkayeiqRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTF 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 260 LSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15192 234 LDVLIQLKVIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
40-310 4.99e-34

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 126.41  E-value: 4.99e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH------AGGDPMCKILIGLYFVG 113
Cdd:cd15172   2 FVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVyeahqwIFGNFSCKLLRGIYAIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSAR-RRVPCGIITSVLAWVTAILATLPEFV---VYKPQMEDQkYKCAFSrtpfL 189
Cdd:cd15172  82 FYSGMLLLACISVDRYIAIVQATKSFRLRsRTLAYSKLICAAVWLLAILISLPTFIfseVYDFGLEEQ-YVCEPK----Y 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETF--WKhFLTLKMNISV-LVLPLFIFTFLYVQMRKTLRFRE--QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTfK 264
Cdd:cd15172 157 PKNSTAimWK-LLVLSLQVSLgFFIPLLVMIFCYSFIIKTLLQAQnsQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEA-I 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 68215224 265 EHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd15172 235 NLGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNY 280
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
42-303 1.81e-33

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 124.89  E-value: 1.81e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGLY 115
Cdd:cd15177   4 PCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETlqgwifGNAMCKLIQGLYAINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKgnfFSARRRVPC----GIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsRTPFLPA 191
Cdd:cd15177  84 SGFLFLTCISVDRYVVIVRA---TSAHRLRPKtlfySVLTSLIVWLLSILFALPQLIYSRVENRSELSSC---RMIFPEV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFRE--QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd15177 158 VSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARgwERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATL 237
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 270 SD-CKSSYNLDKSVHITKLIATTHCCINPLLYAFL 303
Cdd:cd15177 238 ELsCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFV 272
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
40-309 3.10e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 124.33  E-value: 3.10e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYllgywpfGEVMCKIVLSVDAY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGI-ITSVLAWVTAILATLPeFVVYK--PQMEDQKYKCAFSrtpfL 189
Cdd:cd14970  82 NMFTSIFCLTVMSVDRYLAVVHP--VKSLRFRTPRKAkLVSLCVWALSLVLGLP-VIIFArtLQEEGGTISCNLQ----W 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR---------FREQRYSLFK---LVFAIMVVFLLMWAPYNIa 257
Cdd:cd14970 155 PDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRssrnlstsgAREKRRARRKvtrLVLVVVAVFVVCWLPFHV- 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 258 fflstfkehFSLSDCKSSYNLDKSV----HITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd14970 234 ---------FQIVRLLIDPPETLTVvgvfLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-307 1.41e-32

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 122.55  E-value: 1.41e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYF 111
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATyysygynwLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLAWVTAILATLPEFVV--YKPQMEDQKYKCAFSrtpFL 189
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYP--LRSQRRRSWQARLVCLLVWVLACLSSLPTFYFrdTYYIEELGVNACIMA---FP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL-------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLST 262
Cdd:cd15191 157 NEKYAQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLlktkgfgKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDA 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 263 FKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15191 237 LARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHF 281
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
25-309 4.42e-32

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 122.32  E-value: 4.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   25 AEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVkYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------ 98
Cdd:PHA02834  15 EEECDFEMVNSDVNYFVIVFYILLFIFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDlnewif 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   99 GDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSarRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQK 178
Cdd:PHA02834  94 GEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKN--KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  179 YKCAFSrtpflPADETF-WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF--REQRYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:PHA02834 172 KQCIFN-----DYHENFsWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNckNKNKTRSIKIILTVVTFTVVFWVPFN 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224  256 IAFFLSTFKEhFSLSDCkSSYNLDK---SVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:PHA02834 247 IVLFINSLQS-VGLIDI-GCYHFKKivySIDIAELISFVHCCVNPIIYAFVGKNFKK 301
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
40-311 2.86e-31

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 119.10  E-value: 2.86e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVG 113
Cdd:cd15179   2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAaanwyfGNFLCKAVHVIYTVN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNffSAR-RRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLPAD 192
Cdd:cd15179  82 LYSSVLILAFISLDRYLAIVHATN--SQRpRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYIC----DRIYPED 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 E-TFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFRE--QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd15179 156 TfELWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKghQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEII 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 270 -SDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15179 236 kQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
48-329 9.26e-31

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 120.50  E-value: 9.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   48 VFVIGVLDNLLVVLILVkYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG------GDPMCKILIGLYFVGLYSETFFN 121
Cdd:PHA02638 108 IFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEfdqwifGDFMCKVISASYYIGFFSNMFLI 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  122 CLLTVQRYLVFLHKGNfFSARRRVPCGIITSVLAWVTAILATLPEF-------VVYKPQMEDQ---KYKCAFSRTPfLPA 191
Cdd:PHA02638 187 TLMSIDRYFAILYPIS-FQKYRTFNIGIILCIISWILSLIITSPAYfifeasnIIFSAQDSNEtisNYQCTLIEDN-EKN 264
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR--FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:PHA02638 265 NISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKqlKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATMYSFKGF 344
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224  270 SDCKSSY-----NLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCF-HLRSNTPLQPRGQS 329
Cdd:PHA02638 345 NSIISEHicgfiKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFrNIFTNAKFSFRKSS 410
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
41-309 1.75e-30

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 116.77  E-value: 1.75e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYFV 112
Cdd:cd15193   3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTalggqwlfGEGLCKLSSFIIAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYL--VFLHKGNFFSARRrvpCGIITSVLAWVTAILATLPEFVVYKPQMEDQkykCAFSRTPFLP 190
Cdd:cd15193  83 NRCSSILFLTGMSVDRYLavVKLLDSRPLRTRR---CALITCCIIWAVSLVLGIPSLVYRNLINESV---CVEDSSSRFF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTlkmnisvLVLPLFIFTFLYVQMRKTLR---------FREQRYSLfKLVFAIMVVFLLMWAPYNI--AFF 259
Cdd:cd15193 157 QGISLATLFLT-------FVLPLIVILFCYCSILVRLRrhfhgakrtGRRRRNSL-RIVFAIVTAFVLSWLPFNTlkAVR 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 68215224 260 LSTFKEHFSLSdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15193 229 LLLELGGGVLP-CHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
44-304 2.17e-29

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 114.08  E-value: 2.17e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHA--------GGDPMCKILIGLYFVGLY 115
Cdd:cd14987   6 FYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSlvqhnqwpMGEFTCKITHLIFSINLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsVLAWVTAILATLPEfvVYKPQMEDQKYKCAFSRTPFLPaDETF 195
Cdd:cd14987  86 GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIIC-VLVWLLAFVASLPD--TYFLKTVTSPSNNETYCRSFYP-EESF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVL--VLPLFIFTFLYVQMRKTLRFR--EQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKE-HFSLS 270
Cdd:cd14987 162 KEWLIGMELVSIVLgfVIPFPIIAVFYFLLARAISASsdQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFlHLIPF 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLD 304
Cdd:cd14987 242 SCQLENFLYAALHVTQCFSLVHCCVNPILYSFIN 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-309 1.39e-27

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 109.09  E-value: 1.39e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHA--------GGDPMCKILIGLYF 111
Cdd:cd15189   2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNilnqfnwpFGELLCRVVNGVIK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnfFSAR--RRVPCGIITSVLAWVTAILATLPEFVVYKPQM--EDQKYKCAFSrtp 187
Cdd:cd15189  82 VNLYTSIYLLVMISQDRYLALVKT---MAARrlRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLL--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 fLPADEtfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQrySLFK----------LVFAIMVVFLLMWAPYNIA 257
Cdd:cd15189 156 -YPHEA--WHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTREE--STRCedrndskataLVLAVTLLFLVCWGPYHFF 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 258 FFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15189 231 TFLDFLFDVGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
46-309 3.79e-27

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 108.08  E-value: 3.79e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL--CfLLTLPFWAHAG-------GDPMCKILIGLYFVGLYS 116
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLllC-LVSLPFTLIYTltknwpfGSILCKLVPSLQGVSIFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFV------VYKPQMEDQKYKCafsrtpflp 190
Cdd:cd15203  87 STLTLTAIAIDRYQLIVYP---TRPRMSKRHALLIIALIWILSLLLSLPLAIfqelsdVPIEILPYCGYFC--------- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 aDETFWKHFLTLKMNISVLVL----PLFIFTFLYVQMRKTLRFR-------------------EQRYSLFKLVFAIMVVF 247
Cdd:cd15203 155 -TESWPSSSSRLIYTISVLVLqfviPLLIISFCYFRISLKLRKRvkkkrgkrtlssrrrrselRRKRRTNRLLIAMVVVF 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68215224 248 LLMWAPYNIAFFLSTFKEHFSLSDCKSSYnldksVH-ITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15203 234 AVCWLPLNLFNLLRDFEPLPQIDGRHFYL-----IFlICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
48-309 2.20e-24

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 100.61  E-value: 2.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWA--------HAGGDPMCKILIGLYFVGLYSETF 119
Cdd:cd15381  10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAinisngfnWPFGEFLCKSVNAVIYMNLYSSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHKGNFfSARRRVPCGIITSVLAWVTAILATLPEFVvykpqMEDQKYKCAFSRTP-FLPADETFWKH 198
Cdd:cd15381  90 FLMMVSIDRYLALVKTMSS-GRMRRPACAKLNCLIIWMFGLLMSTPMIV-----FRTVMYFPEYNITAcVLDYPSEGWHV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLTLKMNISVLVLPLFIFTFLYVQMRKTLRFRE-QRYSLF-------KLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd15381 164 ALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKmQKFKEIqterkatVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLIS 243
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15381 244 GCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
40-315 6.68e-24

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 99.26  E-value: 6.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYlmnswpfGDVLCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVV--YKPQMEDQKYKCAFSrtpFLP 190
Cdd:cd15091  82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKII-NICIWLLSSSVGISAIVLggTKVREDVDSTECSLQ---FPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFIFTFLYVQM---RKTLRF----REQRYSL---FKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15091 158 DDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLMilrLKSVRLlsgsREKDRNLrriTRLVLVVVAVFVVCWTPIHIFILV 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 261 StfkehfSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSkylcRCF 315
Cdd:cd15091 238 E------ALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFK----RCF 282
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
40-309 6.79e-24

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 99.29  E-value: 6.79e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL----------TLPFWAHagGDPMCKILIGL 109
Cdd:cd15096   2 VVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVfcvpftatdyVLPTWPF--GDVWCKIVQYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLPEF----VVYKPQMEDQKYKCAF 183
Cdd:cd15096  80 VYVTAYASVYTLVLMSLDRYLAVVHpiTSMSIRTERNT---LIAIVGIWIVILVANIPVLflhgVVSYGFSSEAYSYCTF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 SRTPFlPADETFWKHFltlkmNISVLVLPLFIFTFLYVQMRKTLRF------------REQRYSLFKLVFAIMVVFLLMW 251
Cdd:cd15096 157 LTEVG-TAAQTFFTSF-----FLFSYLIPLTLICVLYMLMLRRLRRqkspggrrsaesQRGKRRVTRLVVVVVVVFAICW 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 252 APYNIAFFLstfkehfslsdckSSYNLDKSVHITKLI-------ATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15096 231 LPIHIILLL-------------KYYGVLPETVLYVVIqilsnclAYGNSCVNPILYAFLSQNFRK 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
46-307 8.01e-24

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 99.21  E-value: 8.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTL-----PFWAHagGDPMCKILIGLYFVGLY 115
Cdd:cd14993   8 VVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLlvslfCMPLTLlenvyRPWVF--GEVLCKAVPYLQGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLH--KGNFFSARRRVpCGIITSVlaWVTAILATLPEFVVYKpqmEDQKYKCAFSRTPFLPADE 193
Cdd:cd14993  86 ASVLTLVAISIDRYLAICYplKARRVSTKRRA-RIIIVAI--WVIAIIIMLPLLVVYE---LEEIISSEPGTITIYICTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TF----WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFRE------------------QRYSLFKLVFAIMVVFLLMW 251
Cdd:cd14993 160 DWpspeLRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKppgdrgsanstssrrilrSKKKVARMLIVVVVLFALSW 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 252 APYNIAFFLSTFkehFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd14993 240 LPYYVLSILLDF---GPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKF 292
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
46-307 1.10e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 98.12  E-value: 1.10e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LP------FWAH-AGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15001   7 VITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPlktaeyFSPTwSLGAFLCKAVAYLQLLSFICS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLPEFVVYKpQMEDQKYKCAFSRTPFLPADETF 195
Cdd:cd15001  87 VLTLTAISIERYYVILHpmKAKSFCTIGRA---RKVALLIWILSAILASPVLFGQG-LVRYESENGVTVYHCQKAWPSTL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFIFTFLYVqmrktlrfREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEhfslsDCKSS 275
Cdd:cd15001 163 YSRLYVVYLAIVIFFIPLIVMTFAYA--------RDTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDV-----ISTLH 229
                       250       260       270
                ....*....|....*....|....*....|...
gi 68215224 276 YNLDKSVHIT-KLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15001 230 TQALKYMRIAfHLLSYANSCINPIIYAFMSKNF 262
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
40-307 1.15e-23

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 98.72  E-value: 1.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYF 111
Cdd:cd15380   2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAEnirnqfnwPFGNFLCRVISGVIK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVVYKPQM--EDQKYKCAfsrtpfL 189
Cdd:cd15380  82 ANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVI-CLLIWVFGGLLSIPTFLFRSVKHvpDLNISACI------L 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR--EQRYSLFK--------LVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15380 155 LFPHEAWHFARRVELNIVGFLLPLAAIVFFNFHIIASLRERteESRKRCGGlkdtkatrLILTLVLMFLVCWTPYHFFAF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 68215224 260 LSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15380 235 LDFLFQVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLF 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
40-311 1.77e-22

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 95.21  E-value: 1.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYF 111
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHqfaidgqwYFGEVMCKIITALDA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPEFVVYKP-QMEDQKYKCAFSrtpFL 189
Cdd:cd15088  82 NNQFTSTYILTAMSVDRYLAVVHP--IRSTKYRTRfVAKLVNVGLWAASFLSILPVWVYSSLiYFPDGTTFCYVS---LP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWkhfLTLKMNISVLVLPLFIFTFLYVQMRKTL---------RFREQRY-SLFKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15088 157 SPDDLYW---FTIYHFILGFAVPLVVITVCYILILHRLargvapgnqSHGSSRTkRVTKMVILIVVVFIVCWLPFHVVQL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 260 L--------STFKEHFSLSDCKSSYNldksvhitkliatthCCINPLLYAFLDGTFSKYL 311
Cdd:cd15088 234 VnlamnrptLAFEVAYFLSICLGYAN---------------SCLNPFVYILVSENFRKRL 278
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
40-307 1.81e-22

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 95.14  E-value: 1.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYF 111
Cdd:cd15160   2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDytanhhnwTFGPLSCKVVGFFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFlpa 191
Cdd:cd15160  82 TNIYASIGFLCCIAVDRYLAVVHPLRFRG-LRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCYEKYPM--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 dETFWKHFLTLKMNISVLvLPLFIFTFLYVQMRKTLR-----FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEH 266
Cdd:cd15160 158 -EGWQASYNYARFLVGFL-IPLSLILFFYRRVLRAVRqspslEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIEL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 267 FSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15160 236 VQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDV 276
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-309 2.31e-22

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 94.84  E-value: 2.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15093   2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNalrhwpfGSVLCRLVLSVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNffSAR-RRVPCGIITSVLAWVTAILATLPEFVVYKP-QMEDQKYKCAFSrtpfLP 190
Cdd:cd15093  82 NMFTSIFCLTVMSVDRYLAVVHPIK--SARwRRPRVAKVVNLAVWVASLLVILPVVVFAGTrENQDGSSACNMQ----WP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFI----FTFLYVQMRKT------LRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15093 156 EPAAAWSAGFIIYTFVLGFLLPLLIiclcYLLIVIKVKSAglragwQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 261 STFKEHFSLSDCKSSYnldksvHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15093 236 NVFVQLPETPALVGVY------HFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
46-308 3.59e-22

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 94.75  E-value: 3.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL--CFLLTLP------FWAHAGGDPMCKILIGLYFVGLYSE 117
Cdd:cd14986   8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLvvAFFTVLTqiiweaTGEWVAGDVLCRIVKYLQVVGLFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIitsVLAWVTAILATLPEFVV-YKPQMEDQKYKCafsrtpflpadetfW 196
Cdd:cd14986  88 TYILVSMSLDRYQAIVKPMSSLKPRKRARLMI---VVAWVLSFLFSIPQLVIfVERELGDGVHQC--------------W 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLK--------MNISVLVLPLFIFTFLYVQMRKTL----------------------RFREQRYSLF--------K 238
Cdd:cd14986 151 SSFYTPWqrkvyitwLATYVFVIPLIILSYCYGRILRTIwirsrqktdrpiaptamscrsvSCVSSRVSLIsrakiktiK 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 239 LVFAIMVVFLLMWAPYNIAFFLSTFkehfslSDCKSsyNLDKSVHITKLIATTHCCINPLLYAFLDGTFS 308
Cdd:cd14986 231 MTLVIILAFILCWTPYFIVQLLDVY------AGMQQ--LENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
47-311 7.89e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 93.30  E-value: 7.89e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFW--------AHAGGDPMCKILIGLYFVGLYSET 118
Cdd:cd14988   9 VIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWmlevmldyTWLWGSFLCKFTHYFYFANMYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGNFF----SARRRVPCGIItsvlaWVTAILATLPEfVVYKPQMEDQKYKCAFSrTPFLPADEt 194
Cdd:cd14988  89 FFLTCLSVDRYLTLTSSSPFWqqhqHRIRRALCAGI-----WVLSAIIPLPE-VVHMQLLDGVEPMCLFL-APFETYDE- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 fWKHFLTLKMNISVLVLP---LFIFTFLYV-QMRKTLRFREQRYSLfkLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd14988 161 -WALAVSLLTLIIGFLIPfsiIAVFNVLTArYIRTAGRPESRRHCL--LIYAYILVFVVCWLPYHVTLLLLTLHGSHISL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14988 238 HCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
43-315 1.14e-21

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 93.14  E-value: 1.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVG 113
Cdd:cd15090   5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFqsvnylmgtWPF--GNILCKIVISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPcgiITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFsrtpFLPA 191
Cdd:cd15090  83 MFTSIFTLCTMSVDRYIAVCHpvKALDFRTPRNAK---IVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTL----TFSH 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMrkTLRFREQRY------------SLFKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15090 156 PSWYWENLLKICVFIFAFIMPVLIITVCYGLM--ILRLKSVRMlsgskekdrnlrRITRMVLVVVAVFIVCWTPIHIYVI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 260 LStfkehfSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSkylcRCF 315
Cdd:cd15090 234 IK------ALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK----RCF 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
44-307 1.52e-21

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 92.24  E-value: 1.52e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLyFVGLY 115
Cdd:cd14967   5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTllgywpfGPVLCRFWIAL-DVLCC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFN-CLLTVQRYLVF---LHKGNFFSARRrvpcGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPa 191
Cdd:cd14967  84 TASILNlCAISLDRYLAItrpLRYRQLMTKKR----ALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 detfwkhFLTLkMNISVLVLPLFIFTFLYVQMRKTLRfREQRysLFKLVFAIMVVFLLMWAPYNIAFFLSTFkehfslsd 271
Cdd:cd14967 159 -------YVLV-SSVISFFIPLLIMIVLYARIFRVAR-RELK--AAKTLAIIVGAFLLCWLPFFIIYLVSAF-------- 219
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 68215224 272 CKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd14967 220 CPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDF 255
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
39-311 2.28e-21

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 92.18  E-value: 2.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----WAHAG----GDPMCKILIGLY 110
Cdd:cd15921   1 LFYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLrltyYVLNShwpfGDIACRIILYVL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKGNFFS----ARRRVPCGIItsvlaWVTAILATLPEFVVYKPQMEDQKYKCAfsRT 186
Cdd:cd15921  81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRvqthSVAGIICGLI-----WILMGLASSPLLFAKSKQHDEGSTRCL--EL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFLPADETFWKHFLTLKMNisvLVLPLFIFTFLYVQMRKTL--------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAF 258
Cdd:cd15921 154 AHDAVDKLLLINYVTLPVG---FVVPFMTVIFCYIFIIKNLlkpspalgRTRPSRRKACALIIISLGIFLVCFLPYHIVR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 259 FLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15921 231 TIHLITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
39-311 2.80e-21

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 92.12  E-value: 2.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP----FWAHAG----GDPMCKILIGLY 110
Cdd:cd15158   1 QVYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPlrvvYYVHKGqwlfGDFLCRISSYAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYL--VF-LHKGNFFSARR-RVPCGIItsvlaWVTAILATLPeFVVYKPQM-EDQKYKCafsr 185
Cdd:cd15158  81 YVNLYCSIYFMTAMSFTRFLaiVFpVQNLNLVTVKKaRIVCVGI-----WIFVTLTSSP-FLMSGSHDtETNKTKC---- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 tpFLPADETFWKHFLtLKMNISVLV----LPLFIFTFLYVQMRKTL-----RFREQRYSLFKLVFAIMVV---FLLMWAP 253
Cdd:cd15158 151 --FEPPQSNQQLTKL-LVLNYISLVvgfiIPFLVILICYAMIIRTLlkntmKARKQQSSRKKAIRMIIIVllaFLVSFMP 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 254 YNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15158 228 YHIQRTIHLHFLSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-315 3.51e-21

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 91.47  E-value: 3.51e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15092   8 LIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFqgtdiflgfWPF--GNALCKTVIAIDYYNMFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpfLPADETFW 196
Cdd:cd15092  86 STFTLTAMSVDRYVAICHPIKALDVRTPHKAKVV-NVCIWALASVVGVPVMVMGSAQVEDEEIECLVE----IPTPQDYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-------FREQRYSL---FKLVFAIMVVFLLMWAPYNIaFFLSTfkeh 266
Cdd:cd15092 161 DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRgvrllsgSKEKDRNLrriTRLVLVVVAVFVGCWTPIQI-FVLAQ---- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 267 fSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSkylcRCF 315
Cdd:cd15092 236 -GLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFK----ACF 279
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
40-305 1.36e-20

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 89.92  E-value: 1.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHA--------GGDPMCKILIGLYF 111
Cdd:cd15194   2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKevvlgpwrSGSFLCKGSSYIIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVpCGIITSVLAWVTAILATLPEFVVYK-PQMEDQKYKCAFSRTPFlp 190
Cdd:cd15194  82 VNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKH-NAKVCCTCVWMLSCLLGLPTLLSRElKKYEEKEYCNEDAGTPS-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 adetfwKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL-----RFREQRYSL---FKLVFAIMVVFLLMWAPYNIAFFLST 262
Cdd:cd15194 159 ------KVIFSLVSLIVAFFLPLLSILTCYCTIIWKLchhyqKSGKHQKKLrksIKIVFIVVAAFVFSWMPFNLFKALAI 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 263 FKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDG 305
Cdd:cd15194 233 ASGLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDR 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
46-311 1.42e-20

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 89.96  E-value: 1.42e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---CFLLTLPFWAHA-----GGDPMCKIL-IGLYFVGLYS 116
Cdd:cd14969   8 SLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLlmsVVGYPLSFYSNLsgrwsFGDPGCVIYgFAVTFLGLVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETffncLLTV---QRYLVFLH-KGNFFSARRRVPCGIItsvLAWVTAILATLPEFV---VYKPQMedQKYKCAFSRTPFL 189
Cdd:cd14969  88 IS----TLAAlafERYLVIVRpLKAFRLSKRRALILIA---FIWLYGLFWALPPLFgwsSYVPEG--GGTSCSVDWYSKD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLR-------------------FREQRYslFKLVFAIMVVFLLM 250
Cdd:cd14969 159 PNSLSY-----IVSLFVFCFFLPLAIIIFCYYKIYRTLRkmskraarrknsaitkrtkKAEKKV--AKMVLVMIVAFLIA 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 251 WAPYNIAFFLSTFKEHFSLSdckssynlDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14969 232 WTPYAVVSLYVSFGGESTIP--------PLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
40-311 2.45e-20

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 89.49  E-value: 2.45e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGlKRVENIYLLNLAVSNLCFLLTLPF----WAHAG----GDPMCKILIGLYF 111
Cdd:cd15339   2 ILPSFIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVMPFlihqWARGGewvfGSPLCTIITSLDT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNfFSARRRVPCGIITSVLAWVTAILATLPEFVVYK-PQMEDQKYKCAFSRTpflP 190
Cdd:cd15339  81 CNQFACSAIMTAMSLDRYIALVHPFR-LTSLRTRSKTIRINLLVWAASFILVLPVWVYAKvIKFRDGLESCAFNLT---S 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWkhfLTLKMNISVLVLPL-FIFTF----------LYVQMRKTLRF-----REQRYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd15339 157 PDDVLW---YTLYQTITTFFFPLpLILICyililcytweMYRKNKKAGRYntsipRQRVMRLTKMVLVLVGVFLVSAAPY 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 255 NIAFFLstfkehfSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15339 234 HVIQLV-------NLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
48-309 2.51e-20

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 89.46  E-value: 2.51e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYSET 118
Cdd:cd15094  10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFlivtmilkyWPF--GAAMCKIYMVLTSINQFTSS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGNffSARRRVP-CGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCA--FSRTPFLPADETF 195
Cdd:cd15094  88 FTLTVMSADRYLAVCHPIR--SMRYRTPfIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTivWPDSSAVNGQKAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFiFTFLYVQMR------KTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHfsl 269
Cdd:cd15094 166 TLYTFLLGFAIPLLLISVF-YTLVILRLRtvgpknKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPP--- 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 270 SDCKSSYNLDKSVHITkLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15094 242 GTDMPKWEILMFLLLT-VLSYANSMVNPLLYAFLSENFRK 280
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
44-311 6.66e-20

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 87.74  E-value: 6.66e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLIlVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFVG 113
Cdd:cd14974   6 LYALIFLLGLPGNGLVIWV-AGFKMKRTVNTVWFLNLALADFLFCLFLPFlivyiamghhWPF--GSVLCKLNSFVISLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKgNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADE 193
Cdd:cd14974  83 MFASVFLLTAISLDRCLLVLHP-VWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDLRR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFwKHFLTLKMNISVLVLPLFIFTFLY----VQMRKTLRFREQRYslFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd14974 162 SR-HKALTVIRFLCGFLLPLLIIAICYsviaVKLRRKRLAKSSKP--LRVLLAVVVAFFLCWLPYHVFALLELVAAAGLP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 270 SdckssyNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14974 239 E------VVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-309 1.61e-19

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 87.51  E-value: 1.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  28 CDkYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLK-RVENIYLLNLAVSNLCFLLTLPFWA-------H-AG 98
Cdd:cd15190   1 CD-YTEWKPSYALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRrRSADTFIANLALADLTFVVTLPLWAvytalgyHwPF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  99 GDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVYKP--QMED 176
Cdd:cd15190  80 GSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVI-WLLAALLALPALILRTTsdLEGT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 177 QKYKCAFSRTPFLPAD-ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL-------RFREQ--RYSLFKLVFAIMVV 246
Cdd:cd15190 159 NKVICDMDYSGVVSNEsEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVarhfsklRRKEDkkKRRLLKIIITLVVT 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 247 FLLMWAPYNIaffLSTFKEHFSLSDCKSSYNLDKSVHITKLIAT----THCCINPLLYAFLDGTFSK 309
Cdd:cd15190 239 FALCWLPFHL---VKTLYALMYLGILPFSCGFDLFLMNAHPYATclayVNSCLNPFLYAFFDPRFRQ 302
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 2.68e-19

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 86.34  E-value: 2.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYflkkwyfGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLAWVTAILATLPEFVVYkpQMEDQKYKCAFSRTPFLPA- 191
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKP--LDTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMI--RLVTVEDKSGGSKRICLPTw 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVlPLFIFTFLYVQMRKTL-----------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd14999 157 SEESYKVYLTLLFSTSIVI-PGLVIGYLYIRLARKYwlsqaaasnssRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 261 STFKEHFSLSDcKSSYNLDksvHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14999 236 YLYSPSLSLSP-RTTTYVN---YLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
41-315 2.69e-19

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 86.54  E-value: 2.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYF 111
Cdd:cd15089   3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFqsakylmetWPF--GELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVVYKPQ-MEDQKYKCAFSrtpfLP 190
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLI-NICIWVLSSGVGVPIMVMAVTKtPRDGAVVCMLQ----FP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-------FREQRYSLFKLVFAIMVV---FLLMWAPYNIAFFL 260
Cdd:cd15089 156 SPSWYWDTVTKICVFIFAFVVPILVITVCYGLMILRLRsvrllsgSKEKDRNLRRITRMVLVVvaaFIICWTPIHIFVIV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 261 STFKEhfslSDCKSSYNLdKSVHITKLIATTHCCINPLLYAFLDGTFSkylcRCF 315
Cdd:cd15089 236 WTLVD----IDRRNPLVV-AALHLCIALGYANSSLNPVLYAFLDENFK----RCF 281
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
42-311 5.13e-19

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 85.54  E-value: 5.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFV 112
Cdd:cd15378   4 PTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMlvysysngqWLF--GDFLCKSNRYLLHA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLH--KGNFFSARRrvpCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLP 190
Cdd:cd15378  82 NLYSSILFLTFISIDRYLLIKYpfREHILQKKR---SAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLkmniSVLVLPLFIFTFLYVQMRKTLRFREQRYSL-------FKLVFAIMVVFLLMWAPYNIA--FFLS 261
Cdd:cd15378 159 TNSLIYSLFLTV----TGFLIPLCVMCFFYYKIALFLKNRNRQLANatsfekpLTLVILAVVIFSVLFTPYHVMrnVRIA 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 68215224 262 TFKEHFSLSDCKSSYnLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15378 235 SRLDSIGVSECTLII-IKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
40-311 7.73e-19

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 85.25  E-value: 7.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVE--NIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGL 109
Cdd:cd14976   2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTDLIFVLTLPFWAVEYaldfvwpfGTAMCKVVRYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNffSARRRVPCGI-ITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTP- 187
Cdd:cd14976  82 TKLNMYSSIFFLTALSVTRYIAVARALK--HGWIRKAFGAfATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRFPk 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 -FLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQM-----RKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd14976 160 nSSVTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLlrflqRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWS 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 262 TFKEhFSLSDCKSSYNL--DKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14976 240 ALIK-FDDVPFSDAFFAfqTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
48-311 1.80e-18

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 84.07  E-value: 1.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH-------AGGDPMCKILIGLYFVGLYSETFF 120
Cdd:cd15153  10 IFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHyyiqhtwPFGRFLCLLCFYLKYLNMYASICF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 121 NCLLTVQRYLVFLHKGNFFSARRRVPCGIitSVLAWVTAILATLPEFVVYKPQMEDQKYKCaFSRTPFLPADETFWKHFL 200
Cdd:cd15153  90 LTCISIQRCFFLLHPFKARDWKRRYDVGI--SAAVWIVVGLACLPFPLLRSKSLSNNNRSC-FADLGMKKLNFGAAIAMM 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 201 TLKmNISVLVLPLFIFTFLYVQMRKTLRFREQ-------RYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCK 273
Cdd:cd15153 167 TVA-ELFGFVIPLFIIAWCTWKTENSLRQRNKqqqstseKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESIITNCE 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 274 SSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15153 246 VSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
40-311 1.85e-18

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 84.26  E-value: 1.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL----------TLPFWAHagGDPMCKILIGL 109
Cdd:cd15095   2 LVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVccvpftaalyATPSWVF--GDFMCKFVNYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCG-IITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRtpf 188
Cdd:cd15095  80 MQVTVQATCLTLTALSVDRYYAIVHP--IRSLRFRTPRVaVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQTYCR--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 lpadETFW-KHFLTLKMNISVL---VLPLFIFTFLYVQMRKTL----------------RFREQRYSLFKLVFAIMVVFL 248
Cdd:cd15095 155 ----EVWPsKAFQKAYMIYTVLltyVIPLAIIAVCYGLILRRLwrrsvdgnnqseqlseRALRQKRKVTRMVIVVVVLFA 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 249 LMWAPYNIAFFLSTFkehfslsdcksSYNLDKSVHITKLIATTHC------CINPLLYAFLDGTFSKYL 311
Cdd:cd15095 231 ICWLPNHVLNLWQRF-----------DPNFPETYATYALKIAALClsyansAVNPFVYAFMGENFRKYF 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-309 1.99e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 84.06  E-value: 1.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL----------TLPFWAHagGDPMCKILIGL 109
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfcvpftatiyPLPGWVF--GDFMCKFVHYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPEFVVYK---PQMEDQKYkCAFSr 185
Cdd:cd14971  80 QQVSMHASIFTLVAMSLDRFLAVVYP--LRSLHIRTPrNALAASGCIWVVSLAVAAPVLALHRlrnYTPGNRTV-CSEA- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 TPFLPADETFWKHFLtlkmnISVLVLPLFIFTFLYVQMRKTL-----------RFREQRYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd14971 156 WPSRAHRRAFALCTF-----LFGYLLPLLLICVCYAAMLRHLwrvavrpvlseGSRRAKRKVTRLVLVVVVLFAACWGPI 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 255 NIAFFLSTF-KEHFSlsdcKSSYNLDKSVHitkLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd14971 231 HAILLLVALgPFPLT----YATYALRIWAH---CLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
41-307 4.31e-18

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 82.82  E-value: 4.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYFV 112
Cdd:cd15375   3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYyyingeswIFGEFMCKFIRFIFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCA-FSRTPflPA 191
Cdd:cd15375  83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKR-RWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLdFTSSD--NL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLtlkMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFK-----LVFAIMVVFLLMWAPYNIaffLSTFKEH 266
Cdd:cd15375 160 NTIWWYNWI---LTVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSASKqkarrLIILILLVFYVCFLPFHI---LRVVRIE 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 267 FSLsdCKSSYNLDKSVH----ITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15375 234 TRL--PPVSCCLKHQVHaiyiITRPLAALNTFGNLLLYVVSGDNF 276
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
46-315 6.07e-18

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 82.83  E-value: 6.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---WAHA----GGDPMCKILIGLYFVGLYSE 117
Cdd:cd15195   8 WVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMdavWNYTvewlAGDLMCRVMMFLKQFGMYLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItsvLAWVTAILATLPEFVVYK--PQMEDQKY--KCAFSRTPFLPADE 193
Cdd:cd15195  88 SFMLVVIALDRVFAILSPLSANQARKRVKIMLT---VAWVLSALCSIPQSFIFSvlRKMPEQPGfhQCVDFGSAPTKKQE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMnisvLVLPLFIFTFLY-------VQMRKTLR--------------FREQRYSLFKLVFAIMVVFLLMWA 252
Cdd:cd15195 165 RLYYFFTMILS----FVIPLIITVTCYllilfeiSKMAKRARdtpisnrrrsrtnsLERARMRTLRMTALIVLTFIVCWG 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68215224 253 PYNIAFFLSTFKEHFSLSDCKSsynldkSVHITKLIATTHCCINPLLYafldGTFSKYLCRCF 315
Cdd:cd15195 241 PYYVLGLWYWFDKESIKNLPPA------LSHIMFLLGYLNPCLHPIIY----GVFMKEIRNWI 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
46-309 1.02e-17

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 81.90  E-value: 1.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTL--------PFwahagGDPMCKILIGLYFV 112
Cdd:cd15207   8 SLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLlvgvfCMPFTLvdniltgwPF-----GDVMCKLSPLVQGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnfFSAR--RRVPCGIITSVlaWVTAILATLPEFVV--YKPQMEDQKYKCAFSrTPF 188
Cdd:cd15207  83 SVAASVFTLVAIAVDRYRAVVHP---TEPKltNRQAFVIIVAI--WVLALAIMIPQALVleVKEYQFFRGQTVHIC-VEF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADEtfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR-----------------EQRYSLFKLVFAIMVVFLLMW 251
Cdd:cd15207 157 WPSDE--YRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKpvpgggsasreaqaavsKKKVRVIKMLIVVVVLFALSW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 252 APYNIAFFLSTFKehfSLSDcKSSYNLDKSVH-ITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15207 235 LPLHTVTMLDDFG---NLSP-NQREVLYVYIYpIAHWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
40-309 1.14e-17

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 81.71  E-value: 1.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP---------FWAHagGDPMCKILIGLY 110
Cdd:cd15087   2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPiniaehllqQWPF--GELLCKLILSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHK-GNFFSARRRVPCGIITSVLAWVTAILATLPEFV---VYKPqmEDQKYKCAFSrt 186
Cdd:cd15087  80 HYNIFSSIYFLTVMSVDRYLVVLATvRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVfagVYSN--ELGRKSCVLS-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 pfLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR----------FREQRYSLFKLVFAIMVVFLLMWAPYNI 256
Cdd:cd15087 156 --FPSPESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRnmrlnsnakaLDKAKKKVTLMVLVVLAVCLFCWTPFHL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 257 AFF--LSTFKEHFSLSDCKSSYnldksvhITKLiATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15087 234 STVvaLTTDLPQTPLVIGISYF-------ITSL-SYANSCLNPFLYAFLDDSFRK 280
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
46-311 1.25e-17

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 81.97  E-value: 1.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVE-NIYLLNLAVSNLCF-LLTLPF---WAHA----GGDPMCKILIGLYFVGLYS 116
Cdd:cd15382   8 SVLFLIAAVGNLTVLLILLRNRRRKRSRvNILLMHLAIADLLVtFIMMPLeigWAATvawlAGDFLCRLMLFFRAFGLYL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsvlAWVTAILATLPEFVVYKPQmEDQKYK----C---AFSRTpfl 189
Cdd:cd15382  88 SSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAV---AWVISFLCSIPQSFIFHVE-SHPCVTwfsqCvtfNFFPS--- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWkhflTLKMNISVLVLPLFIFTFLYVQM-----RKT-------------LRFREQRYSLF--------KLVFAI 243
Cdd:cd15382 161 HDHELAY----NIFNMITMYALPLIIIVFCYSLIlceisRKSkekkedvseksssVRLRRSSVGLLerarsrtlKMTIVI 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 244 MVVFLLMWAPYNIAFFLSTFkehfslsDCKSSYNLDKSvhITKLI---ATTHCCINPLLYafldGTFSKYL 311
Cdd:cd15382 237 VLVFIICWTPYFIMSLWYWF-------DRESASKVDPR--IQKGLflfAVSNSCMNPIVY----GYFSIDL 294
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
40-307 1.47e-17

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 81.59  E-value: 1.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVV-LILVKYKGLKRVeNIYLLNLAVSNLCFLLTLPFWAHA--------GGDPMCKILIGLY 110
Cdd:cd15168   2 FLPIVYGVVFLVGLLLNSVVLyRFIFHLKPWNSS-AIYMFNLAVSDLLYLLSLPFLIYYyangdhwiFGDFMCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFL 189
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHP--LRSLGKLKKrHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTlkmnISVLVLPLFIFTFLYVQMRKTL--RFREQRYSLFK-----LVFAIMVVFLLMWAPYNI--AFFL 260
Cdd:cd15168 159 LNDYVIYSMVLT----GLGFLLPLLIILACYGLIVRALirKLGEGVTSALRrksirLVIIVLALFAVCFLPFHVtrTINL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 261 StFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15168 235 A-ARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKF 280
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
42-302 2.22e-17

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 80.91  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYFVG 113
Cdd:cd15157   4 PTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADyylmgshwVFGDIACRIMSYSLYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSARR----RVPCGIItsvlaWVTAILATLPEFVVYKPQMEDQKyKCafsrtpfl 189
Cdd:cd15157  84 MYCSIYFLTVLSIVRFLAIVHPFKLWKVTSikyaRILCAVI-----WIFVMAASSPLLSKGTSKYNSQT-KC-------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 pADETFWKHFLTLKMNISVLV----LPLFIFTFLYVQMRKTL--------RFREQRYSLFKLVFAIMVVFLLMWAPYNIa 257
Cdd:cd15157 150 -LDLHPSKIDKLLILNYIVLVvgfiLPFCTLSICYILIIKALlkprvpqsKLRVSHKKALLTIIITLILFLLCFLPYHI- 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 258 fFLSTFKEHFSLSDCKSsyNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15157 228 -LRTVHLMQWSEGQCNL--RLHKAVVITLCLAAANSCLDPLLYYF 269
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
46-308 2.88e-17

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 80.67  E-value: 2.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15156   8 SMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFrifyfvqrnWPF--GDLLCKISVTLFYTNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVVykpqMEDQKYKCAFSRTPFLPADETFW 196
Cdd:cd15156  86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIV-CAAVWLTVLAGSLPASFF----QSTNNQLNNNSETCFENFSSKTW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLT---LKMNISVLVLPLFIFTFLYVQMRKTL-------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEH 266
Cdd:cd15156 161 KTYLSkivIFIEIVGFFIPLILNVTCSTMVLKTLrrpntlsRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 267 FSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFS 308
Cdd:cd15156 241 QTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSETIQ 282
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
40-302 4.60e-17

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 80.09  E-value: 4.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP----FWAHAG----GDPMCKILIGLYF 111
Cdd:cd15159   2 LLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPgriaYYALGFdwpfGDWLCRLTALLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsVLAWVTAILATLPEFVVYKPQMEDQKYKC----AFSRTP 187
Cdd:cd15159  82 INTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYIC-VFVWVLVFLQTLPLLFMPMTKEMGGRITCmeypNFEKIK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FLPadetfwkhFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSL----------FKLVFAIMVVFLLMWAPYNIA 257
Cdd:cd15159 161 RLP--------LILLGACVIGFGVPVGIILFCYSQITLKLCRTAKENPLteksghhkkaCNVILLVLLVFVVCFSPYHLN 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 258 FFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15159 233 IIQFMIRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFF 277
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
44-310 7.60e-17

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 79.40  E-value: 7.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVlDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYFVG 113
Cdd:cd14992   7 LVVIILVSVV-GNFIVIAALARHKNLRGATNYFIASLAISDLLMaLFCTPFnftyvvslsWEY--GHFLCKIVNYLRTVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIITsvlAWVTAILATLPEFVVYKPQ-MEDQKYKCAFSRTPFLP 190
Cdd:cd14992  84 VYASSLTLTAIAFDRYFAIIHplKPRHRQSYTTTVIIIIT---IWVVSLLLAIPQLYYATTEvLFSVKNQEKIFCCQIPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFRE---------------QRYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd14992 161 VDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKvpgfsikeverkrlkCKRRVIKMLVCVVVLFVICWLPFH 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 256 IAFFLSTF-----KEHFSLSdckssynldkSVHITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd14992 241 LFFLLRDFfplimKEKHTLQ----------VYYFLHWIAMSNSMYNPIIYVTLNNNFRKN 290
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
48-302 1.43e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 78.69  E-value: 1.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLIlVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYFVGLYSETF 119
Cdd:cd15118  10 VSTLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYylasghtwELGTTFCRIHSSIFFLNMFVSGF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLhKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKP-QMEDQKYKCAFSRTPFLPADET---- 194
Cdd:cd15118  89 LLAAISLDRCLLVV-KPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDViERKDGRKLCYYNFALFSPSPDNnhpi 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 --FWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQR--YSLFKLVFAIMVVFLLMWAPYNIafflstfkehFSLS 270
Cdd:cd15118 168 ckQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRrpGRFVRLVVSVVVSFALCWAPYHI----------FSII 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 271 DCKSSYN------LDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15118 238 EVMAHNQhslrplVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
48-309 2.02e-16

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 77.97  E-value: 2.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFVGLYSETFF 120
Cdd:cd15973  10 VCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAalqhwpfGSAMCRTVLSVDGINMFTSVFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 121 NCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLP--EFVVYKPQmEDQKYKCAFSRTpflpadETFWK 197
Cdd:cd15973  90 LTVLSVDRYIAVVHP--LRAARYRRPtVAKMINICVWILSLLVISPiiIFADTATR-KGQAVACNLIWP------HPAWS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 HFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-------FREQRYS---LFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHf 267
Cdd:cd15973 161 AAFVIYTFLLGFLLPVLAIGLCYILIIGKMRavalkagWQQRRKSekkITRMVLMVVTVFVICWMPFYVVQLLNLFLPR- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 268 slsdckssynLDKSV-HITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15973 240 ----------LDATVnHASLILSYANSCANPILYGFLSDNFRR 272
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
46-311 2.30e-16

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 78.27  E-value: 2.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLIlVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15116   8 SVVFVLGVLGNGLVIFI-TGFKMKKTVNTVWFLNLAVADFLFTFFLPFsiaytamdfhWPF--GRFMCKLNSFLLFLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKgNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYK--PQMEDQKYKCaFSRTPFLPADE 193
Cdd:cd15116  85 TSVFLLTVISIDRCISVVFP-VWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDtaPSQNNNKIIC-FNNFSLSGDNS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLK----MNISVL----VLPLFIFTFLYVQMrkTLRFREQRYSL----FKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd15116 163 SPEVNQLRNMrhqvMTITRFllgfLIPFTIIICCYAAI--VLKLKRNRLAKsskpFKIIAAVIVTFFLCWAPYHILNLLE 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 68215224 262 TFKEHFslsdckSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15116 241 MEATRS------PASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
48-302 2.46e-16

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 77.88  E-value: 2.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH------AGGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15923  10 TFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHsyrresAGLQKLCNFVLSLYYINMYVSIFTI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLV----FLHKGNFFSARRRVPCGIItsvlaWVTAILATLPEFVVykpQMEDQKYKCaFSRTpflpadETFWK 197
Cdd:cd15923  90 TAISVDRYVAirypLRARELRSPRKAAVVCAVI-----WVLVVTISIPYFLL---DSSNEKTMC-FQRT------KQTES 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 HFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR----EQRYSLFKLVFAIMV---VFLLMWAPYNIAFFLSTFKEhfSLS 270
Cdd:cd15923 155 LKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRlddvGSRSETKQCIRVIMAnliVFIVCFLPVHVGFFVKFIVG--KSY 232
                       250       260       270
                ....*....|....*....|....*....|..
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15923 233 SCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYF 264
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
46-309 2.76e-16

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 77.70  E-value: 2.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTL-PF-----WAHA--GGDPMCKI--LIGLYFvGLY 115
Cdd:cd15074   8 TVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLaiisaFAHRwlFGDIGCVFygFCGFLF-GCC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFnCLLTVQRYLV--FLHKGNFFSARRrvpcGIITSVLAWVTAILATLPEFV---VYKPQMEDQKYKCAFSRTPFLP 190
Cdd:cd15074  87 SINTL-TAISIYRYLKicHPPYGPKLSRRH----VCIVIVAIWLYALFWAVAPLVgwgSYGPEPFGTSCSIDWTGASASV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTL---RFREQR------------YSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd15074 162 GGMSY-----IISIFIFCYLLPVLIIVFSYVKIIRKVkssRKRVAGfdsrskrqhkieRKVTKVAVLICAGFLIAWTPYA 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 256 IAFFLSTFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15074 237 VVSMWSAFGSPDSVPILASI--------LPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-309 2.90e-16

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 77.84  E-value: 2.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVE--NIYLLNLAVSNLCFLL----------TLPFWAHagGDPMCKILI 107
Cdd:cd15098   2 IVPVVFGLIFCLGVLGNSLVITVLARVKPGKRRSttNVFILNLSIADLFFLLfcvpfqatiySLPEWVF--GAFMCKFVH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 108 GLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRR----VPCGIItsvlaWVTAILATLPeFVVYKPQMEDQKYkcaf 183
Cdd:cd15098  80 YFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRrnalLGVLVI-----WVLSLAMASP-VAVHQDLVHHWTA---- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 srtpflpADETF---------WKHFLTLKMNISVLVLPLFIFTFLYVQ----MRKTLRFREQRYSLFK-----LVFAIMV 245
Cdd:cd15098 150 -------SNQTFcwenwpekqQKPVYVVCTFVFGYLLPLLLITFCYAKvlnhLHKKLKNMSKKSERSKkktaqTVLVVVV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68215224 246 VFLLMWAPYNIAFFLSTFKeHFSLSDckSSYNLDKSVHItklIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15098 223 VFGISWLPHHIIHLWVEFG-DFPLTQ--ASFVLRITAHC---LAYANSCVNPIIYAFLSENFRK 280
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
75-303 6.70e-16

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 76.74  E-value: 6.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  75 IYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVp 146
Cdd:cd15365  37 VYLFNLSLSDLLYIVILPLWIDYLwngdnwtlSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIR- 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 147 CGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPadetfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKT 226
Cdd:cd15365 116 TALSVSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKFPLED-----WQARLNLFRICLGYLLPLLIILFCYWKIYQA 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 227 LRFR-----EQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKsvhITKLIATTHCCINPLLYA 301
Cdd:cd15365 191 VRSNqatedQEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRNAKWLYTLYK---ITVALTSLNCIADPFLYC 267

                ..
gi 68215224 302 FL 303
Cdd:cd15365 268 FV 269
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
40-228 8.99e-16

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 76.56  E-value: 8.99e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT------LPFWAHAG---GDPMCKILIGLY 110
Cdd:cd14997   2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVcmpvalVETWAREPwllGEFMCKLVPFVE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIitsVLAWVTAILATLP-----EFVVYKPQMEDQKYKCaf 183
Cdd:cd14997  82 LTVAHASVLTILAISFERYYAICHplQAKYVCTKRRALVII---ALIWLLALLTSSPvlfitEFKEEDFNDGTPVAVC-- 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 68215224 184 sRTPFlpadETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR 228
Cdd:cd14997 157 -RTPA----DTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLV 196
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
44-309 9.07e-16

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 75.96  E-value: 9.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLIL-VKYKglKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFV 112
Cdd:cd15115   6 VLSLTFLLGVPGNGLVIWVAgLKMK--RTVNTIWFLNLAVADLLCCLSLPFsiahlllnghWPY--GRFLCKLLPSIIVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLhKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpFLPAd 192
Cdd:cd15115  82 NMFASVFTLTAISLDRFLLVI-KPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYD---FLVA- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 etfwkhfLTLKMNISVLVLPLFIFTFLYVQMRKTL---RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLStfkehfSL 269
Cdd:cd15115 157 -------ITITRAVFGFLLPLLIIAACYSFIAFRMqrgRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILS------LY 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 270 SDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15115 224 GDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
42-311 9.10e-16

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 76.37  E-value: 9.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYF 111
Cdd:cd15370   4 PIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLkiayhingnnWIY--GEALCKVLIGFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKP-QMEDQKYKCAFSRTPFLP 190
Cdd:cd15370  82 GNMYCSILFMTCLSVQRYWVIVNP--MSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTvFIPALDITTCHDVLPEQL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTlkMNISVLVLPLFIFTFLYVQMRKTLRFRE-------QRYSLFKLVFAIMVVFLLMWAPYNIAFFLstf 263
Cdd:cd15370 160 LVGDMFNYFLS--LAIGVFLFPAFLTAVAYVLMIRALKSSIndesiekKRKRAIKLIVTVLVMYLICFTPSNLLLVV--- 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 68215224 264 keHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15370 235 --HYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
46-311 1.46e-15

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 75.70  E-value: 1.46e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVE-NIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYFVGLYS 116
Cdd:cd15926   8 SVVCALGLVGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDFQFVLTLPFWAVENaldftwlfGKAMCKIVSYVTAMNMYA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFlhKGNFFSARRRVPCGI-ITSVLAWVTAILATLPEFVVYKPQMEDQKYKCaFSRTPFLPADETF 195
Cdd:cd15926  88 SVFFLTAMSVARYHSV--ASALKSKRRRGCCSAkWLCVLIWVLAILASLPNAIFSTTATVSNEELC-LVKFPDNRGNAQF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR-------EQRYSLFKLVFAIMVVFLLMWAPyNIAffLSTFKEHFS 268
Cdd:cd15926 165 WLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKnitgsstKRRSKVTKSVTIVVLSFFLCWLP-NQA--LTTWGILIK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 269 LSDCKSSYNLDKS----VHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15926 242 LNVVHFSYEYFTTqvyiFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
40-309 1.73e-15

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 75.61  E-value: 1.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15974   2 LIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNaisywpfGSFLCRLVMTVDGV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPEFVVYKPQMEDQkyKCAFSrtpfLPA 191
Cdd:cd15974  82 NQFTSIFCLTVMSIDRYLAVVHP--IKSTKWRRPrVAKLINATVWTLSFLVVLPVIIFSDVQPDLN--TCNIS----WPE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFIFTFLY-----------VQMRKTLRFREQRySLFKLVFAIMVVFLLMWAPYniaFFL 260
Cdd:cd15974 154 PVSVWSTAFIIYTAVLGFFGPLLVICLCYllivikvkssgLRVGSTKRRKSER-KVTRMVVIIVVVFVFCWLPF---YML 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHItklIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15974 230 NIVNLIVILPEEPAFVGVYFFVVV---LSYANSCANPILYGFLSDNFKQ 275
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
40-310 2.97e-15

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 75.00  E-value: 2.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL----------TLPFWAHagGDPMCKILIGL 109
Cdd:cd15927   2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtcvpftstiyTLDSWPF--GEFLCKLSEFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSaRRRVPCGIITSVLAWVTAILATLPE-----FVVYKPQMEDQKYKCAfs 184
Cdd:cd15927  80 KDTSIGVSVFTLTALSADRYFAIVNPMRKHR-SQATRRTLVTAASIWIVSILLAIPEaifshVVTFTLTDNQTIQICY-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 rtpflPADETFWKHFLTLKMNISVLV---LPLFIFTFLYVQMRKTL----------------RFREQRYSLFKLVFAIMV 245
Cdd:cd15927 157 -----PYPQELGPNYPKIMVLLRFLVyylIPLLIIGVFYVLMARHLirstrnigsgqnqaaqRQIEARKKVAKTVLAFVV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 246 VFLLMWAPYNIafFLSTFkeHFSLSDCKsSYNLdkSVHITKLIATTHC----CINPLLYAFLDGTFSKY 310
Cdd:cd15927 232 LFAVCWLPRHV--FMLWF--HFAPNGLV-DYNA--FWHVLKIVGFCLSfinsCVNPVALYLLSGSFRRH 293
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
46-307 3.16e-15

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 74.68  E-value: 3.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15389   8 SIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILItLLNTPFtlvrfvnstWVF--GKIMCHLSRFAQYCSVY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPeFVVYKP--QMEDQKYKCAFSRTPFLPADE 193
Cdd:cd15389  86 VSTLTLTAIALDRHRVILHP---LKPRITPCQGVVVIAIIWIMASCLSLP-HAIYQKlvEFEYSNERTRSRCLPSFPEPS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR--------EQRYSL-------FKLVFAIMVVFLLMWAPYNIAF 258
Cdd:cd15389 162 DLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRnaigdvttEQYVAQrrkkkktIKMLMLVVLLFAICWLPLNCYH 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 259 FLSTFKehfslsDCKSSYNLDKSVHitkLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15389 242 VLLSSH------PIRSNSALFFAFH---WLAMSSTCYNPFIYCWLNDSF 281
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
40-302 4.43e-15

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 74.41  E-value: 4.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYF 111
Cdd:cd15367   2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQyvlqhdnwTYSELLCKICGILLY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNfFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPa 191
Cdd:cd15367  82 ENIYISIGFLCCISVDRYLAVVHPFR-FHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCFEHYPIKA- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 detfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF-----REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEh 266
Cdd:cd15367 160 ----WEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKshgtqKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFE- 234
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 68215224 267 fslSDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15367 235 ---RDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF 267
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
46-302 5.22e-15

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 74.03  E-value: 5.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15154   8 SLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLriyyyanhyWPF--GNFLCQFSGSIFQMNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQmeDQKYKCAFSRTPFLPADETFW 196
Cdd:cd15154  86 SCLFLMCINVDRYLAIVHPLRFRHLRRP-KVARLLCLAVWALILGGSVPAAIVHSSS--DCLLHGEKVYRCFESFSDNDW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLKMNISVL--VLPLFIFTFLYVQMRKTL-RFRE----QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTF-KEHFS 268
Cdd:cd15154 163 KGLLPLVVLAEILgfLLPLAAVLYCSCRIFVELcRTQEpqqgRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLlRANLV 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 68215224 269 LSDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15154 243 EDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYF 276
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
51-309 5.54e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 74.07  E-value: 5.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  51 IGVLDNLLVVL-ILVKYKGLKR-VENIYLLNLAVSNLCFLLTLPFW-------AHAGGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15122  13 LGLPGNGFIIWsILWKMKARGRsVTCILILNLAVADGAVLLLTPFFitfltrkTWPFGQAVCKAVYYLCCLSMYASIFII 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVFLHKgnFFSARRRVPcGIITSVLA--WVTAILATLPEFVvYKPQMEDQKYKCAFSRtPFLPADETFWKHF 199
Cdd:cd15122  93 GLMSLDRCLAVTRP--YLAQSLRKK-ALVRKILLaiWLLALLLALPAFV-YRHVWKDEGMNDRICE-PCHASRGHAIFHY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 200 LTLKMNISVLVLPLFIFTFLYVQMR-KTLRFReQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKehfSLSDCKSSYNL 278
Cdd:cd15122 168 TFETLVAFVLPFGVILFSYSVILVRlKGARFR-RRARVEKLIAAIVVAFALLWVPYHVVNLLQVVA---NLAPGEVLEKL 243
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 279 DKSVHITKLIATT----HCCINPLLYAFLDGTFSK 309
Cdd:cd15122 244 GGAAKAARAGATAlaffSSSVNPLLYVFAAGDLIK 278
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
40-311 5.69e-15

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 74.02  E-value: 5.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENI--YLLNLAVSNLCFLLTLPFW----AHAGG----DPMCKILIGL 109
Cdd:cd15147   2 LFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWivyyHNEGNwilpKFLCNVAGCL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLH--KGNFFSARRRvpcGIITSVLAWVTAILATLPeFVVYKPQMEDQKYKCAFSRtp 187
Cdd:cd15147  82 FFINTYCSVAFLGVISYNRYQAVTRpiKTAQSTTRKR---GIIISVAIWVIIVASASY-FLFMDSTNTVKIDSGNFTR-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 flpADETFWKHFLTLKMNISVLVLPLFIFTFLYV-------------QMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd15147 156 ---CFEGYEKDNSKPVLIIHFIIIGLFFLVFLLIlvcnlviartllsQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPH 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 255 NI---AFFLSTFkEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15147 233 HVvqgPWTLAVL-QQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
48-309 8.67e-15

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 73.34  E-value: 8.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHA-------GGDPMCKILIGLYFVGLYSETFF 120
Cdd:cd15971  10 VCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQvalvhwpFGKAICRVVMTVDGINQFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 121 NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVYKPQMEDQKYKCafsrTPFLPADETFWKHFL 200
Cdd:cd15971  90 LTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAV-WGVSLLVILPIMIYAGVQTKHGRSSC----TIIWPGESSAWYTGF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 201 TLKMNISVLVLPLFIFTFLY-----------VQMRKTLRFREQRySLFKLVFAIMVVFLLMWAPYNIaFFLSTFKEHFSL 269
Cdd:cd15971 165 IIYTFILGFFVPLTIICLCYlfiiikvkssgIRVGSSKRKKSEK-KVTRMVSIVVAVFVFCWLPFYI-FNVSSVSVSISP 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 270 SDCkssynLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15971 243 TPG-----LKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
40-307 8.95e-15

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 73.60  E-value: 8.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILV--KYKGLKRVENIYLLNLAVSNLCFLL-TLPFWAHAG-------GDPMCKILIGL 109
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLfSVPFRAAAYskgswplGWFVCKTADWF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVlaWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFL 189
Cdd:cd15002  81 GHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASI--WVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMR----KTLRFREQRYS--LFKLVFAIMVVFLLMWAPYNIA-FFLST 262
Cdd:cd15002 159 HEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQrrgtKTQNLRNQIRSrkLTHMLLSVVLAFTILWLPEWVAwLWLIH 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 263 FKEHFSlsdckSSYNLDKSVhiTKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15002 239 IKSSGS-----SPPQLFNVL--AQLLAFSISSVNPIIFLLMSEEF 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
49-302 9.02e-15

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 73.52  E-value: 9.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLL---VVLILVKykglKRVEN-IYLLNLAVSNLCFLLTLPFWAHAGGDP------MCKILIGLYFVGLYSET 118
Cdd:cd15165  11 FVLGLLLNLMalwVFLFKIK----KWTEStIYMINLALNDLLLLLSLPFKMHSSKKQwplgrtLCSFLESLYFVNMYGSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKgnFFSARRRVP--CGIITSVLaWVTAILATLPEFVVYKPQMEdqKYKC--AFSrtpflpaDET 194
Cdd:cd15165  87 LIIVCISVDRYIAIRHP--FLAKRLRSPrkAAIVCLTI-WVFVWAGSIPIYSFHDKPTN--NTRCfhGFS-------NKT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 fWKHFLTLKMNISVLVLPLFIFTFLYVQ-------MRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15165 155 -WSKKVIVVVEEFGFLIPMAVMVFCSVQiirtlldMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKND 233
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 268 SLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15165 234 IINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYF 268
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
42-302 1.15e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 73.29  E-value: 1.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYFVG 113
Cdd:cd15366   4 PTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDyflhrdnwIHGPESCKLFGFIFYTN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFlpade 193
Cdd:cd15366  84 IYISIAFLCCISVDRYLAVAHPLRFAKV-RRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEKYPM----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF-----REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFS 268
Cdd:cd15366 158 EDWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGnvsteQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGK 237
                       250       260       270
                ....*....|....*....|....*....|....
gi 68215224 269 LSDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15366 238 PCDCGFEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
39-304 1.67e-14

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 72.80  E-value: 1.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLL-VVLILVKYKGLKRVeNIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILI 107
Cdd:cd15967   1 QFLPPVYILVFVVGLVGNVWgLKSLLANWKKLGNI-NVFVLNLGLADLLYLLTLPFlvvyylkgrkWIF--GQVFCKITR 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 108 GLYFVGLYSETFFNCLLTVQRYLVFLHKgnfFSARRRVPCG--IITSVLAWVTAILATLPEfvVYKPQMEDQKYKCafsr 185
Cdd:cd15967  78 FCFNLNLYGSIGFLTCISVYRYLAIVHP---MRVMGRITTThsVVISALVWLLVVIQSLPD--LFFSKTNSNGTKC---- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 tpFLPADETFWKHFLT--LKMNISVLVLPLFIFTFLYVQ----------MRKTLRFReqrysLFKLVFAIMVVFLLMWAP 253
Cdd:cd15967 149 --FDTTFNDYLESYLTysLGWTVTGFVIPLLIILGCYGHvvvvlcrnnnVDKGLKQR-----CLKLVIILIVLFSVCYIP 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 254 YNIAFFLSTFKEHFSLSdcKSSYNLDKSVHITKLIATTHCC----INPLLYAFLD 304
Cdd:cd15967 222 YHVFRNLNLLSRILQKQ--GSCTQWFRGIYIAHQVSRGLVClnsaLNPLVYLMGS 274
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
40-307 2.41e-14

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 72.09  E-value: 2.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVkYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGL 109
Cdd:cd15372   2 LVPSLYTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFkisyhflgnnWPF--GEGLCRVVTAF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVP-CGIITSVLAWVTAILATLPeFVVYKpqmedQKYKCAFSRTPF 188
Cdd:cd15372  79 FYGNMYCSVLLLMCISLDRYLAVVHP--FFARTLRSRrFALCMCTAIWLIAAALTLP-LTLQR-----QSYPLERLNITL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 ----LPADET---FWKHFLTLKmnISVLVLPLFIFTFLYVQMRKTLRFREQRYS-LFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15372 151 chdvLPLDEQdtyLFYYFACLA--VLGFLLPLVVILFCYGSVLHTLLRSGQRYGhAMKLTVLVLVSFVLCFTPSNLLLLL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 261 stfkeHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15372 229 -----HYSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEF 270
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
40-302 3.18e-14

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 71.74  E-value: 3.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHA-------GGDPMCKILIGLYFV 112
Cdd:cd14975   2 LGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFlatgtwdFGLAACKGCVYVCAV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLA-WVTAILATLPEF----VVYKPQMEDQKYkCAFSRTp 187
Cdd:cd14975  82 SMYASVFLITLMSLERFLAVSRP--FVSQGWRAKALAHKVLAIiWLLAVLLATPVIafrhVEETVENGMCKY-RHYSDG- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 flpadetfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL---RFREQRYSLfKLVFAIMVVFLLMWAPYNIAFFLSTFK 264
Cdd:cd14975 158 --------QLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLrrrRFRRRRRTG-RLIASVVVAFAACWLPYHVGNLLEVVS 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 265 EHFSLSdcKSSYNLDKSVHITKLIATT----HCCINPLLYAF 302
Cdd:cd14975 229 ELIGGS--KMAGTLGKVAEAGRPIAGAlaflSSSINPLLYAF 268
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
40-309 4.64e-14

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 71.48  E-value: 4.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15970   2 LISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTllrhwpfGSLLCRLVLSVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPC-GIITSVLAWVTAILATLPEFVVYKPQM-EDQKYKCAFsrtpFLP 190
Cdd:cd15970  82 NMFTSIYCLTVLSIDRYIAVVHP--IKAARYRRPTvAKMVNLGVWVFSILVILPIIIFSNTAPnSDGSVACNM----QMP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-------FREQRYSLFKLVFAIMV---VFLLMWAPYNIAFFL 260
Cdd:cd15970 156 EPSQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRvvalkagWQQRKRSERKITLMVMMvvtVFVICWMPFYVVQLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 261 STFKEHfslSDCKSSynldksvHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15970 236 SVFVGQ---HDATVS-------QLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
40-310 7.56e-14

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 70.94  E-value: 7.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGL 109
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFkiayhihgnnWIF--GEALCRLVTVA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVykpqmeDQKYKCAFSRT--- 186
Cdd:cd15162  80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRAR-RYALGTCLAIWLLALLVTLPLYLV------KQTIFLPALDIttc 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 -PFLPADET--FWKHFLtLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYS------LFKLVFAIMVVFLLMWAPYNIA 257
Cdd:cd15162 153 hDVLPEQLLvgDWFYYF-LSLAIVGFLIPFILTASCYVATIRTLAALEDENSekkkkrAIKLAATVLAIFIICFAPSNLL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 258 FFLstfkeHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd15162 232 LLA-----HYSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDH 279
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
46-311 7.57e-14

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 70.72  E-value: 7.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15155   8 SVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFkifynfnrhWPF--GDSLCKISGTAFLTNIYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVYKPQMEDQKYKCafsrtpFLPADETFW 196
Cdd:cd15155  86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGV-WILVLSGGISASLFSTTNVSNTSTTC------FEGFSKSIW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFL---TLKMNISVLVLPLFIFTFLYVQMRKTLR-------FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEH 266
Cdd:cd15155 159 KTYLskiTIFIEVVGFIIPLLLNLTCSSLVLRTLRkpatlsqIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRS 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 267 FSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15155 239 QAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
40-309 8.32e-14

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 70.61  E-value: 8.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLK---RVENIYLLNLAVSNLCFLLTLPFWAHA--------GGDPMCKILIG 108
Cdd:cd15338   2 IMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQllgngvwhFGETMCTLITA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 109 LYFVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPC-GIITSVLAWVTAILATLPEFVVYK-PQMEDQKYKCAFsRT 186
Cdd:cd15338  82 LDTNSQITSTYILTVMTLDRYLATVHP--IRSTKIRTPRvAVAVICLVWILSLLSITPVWMYAGlMPLPDGSVGCAL-LL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFlPADETFWkhfLTLKMNISVLVLPLFIFTFLYVQM------------RKTLRFREQRYSlfKLVFAIMVVFLLMWAPY 254
Cdd:cd15338 159 PN-PETDTYW---FTLYQFFLAFALPLVVICVVYFKIlqnmastvaplpQRSLRVRTKKVT--RMAVAICLAFFICWAPF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 255 NIAFFLstfkeHFSLSDCKSSYNLDKSVHITKLIATThcCINPLLYAFLDGTFSK 309
Cdd:cd15338 233 YILQLA-----HLSIDRPSLAFLYAYNVAISMGYANS--CINPFLYIMLSETFKR 280
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-315 9.39e-14

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 70.53  E-value: 9.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF----LLTLPFWAHAG----GDPMCKILIGLYFVGLYSETF 119
Cdd:cd15197  10 LFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVglinVLTDIIWRITVewraGDFACKVIRYLQVVVTYASTY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsvlAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpaDETFWKHF 199
Cdd:cd15197  90 VLVALSIDRYDAICHPMNFSQSGRQARVLICV---AWILSALFSIPMLIIFEKTGLSNGEVQCWILWP----EPWYWKVY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 200 LTLkMNISVLVLPLFIFTFLYVQMRKTL----------------RFREQRYS-----------LFKLVFAIMVVFLLMWA 252
Cdd:cd15197 163 MTI-VAFLVFFIPATIISICYIIIVRTIwkkskiqvtinkaglhDGSSRRSSsrgiiprakikTIKMTFVIVTVFIICWS 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68215224 253 PYniafFLSTFKEHFSLSDcKSSYNLDKSVHITKLiATTHCCINPLLYAFldgtFSKYLCRCF 315
Cdd:cd15197 242 PY----FVFDLLDVFGLLP-RSKTKIAAATFIQSL-APLNSAINPLIYCL----FSTHLCRPL 294
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
49-301 1.36e-13

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 70.11  E-value: 1.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLLVVLILVKYKglKRVEN---IYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15376  11 FLVAVLGNGLALWLFVTRE--RRPWHtgvVFSFNLAVSDLLYALSLPLlaayyyppknWRF--GEAACKLERFLFTCNLY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKgnfFSARRRVPCG--IITSVLAWVTAILATLPEFVVYKPQMEDQ-KYKCAFSrtpflpAD 192
Cdd:cd15376  87 GSIFFITCISLNRYLGIVHP---FFTRSHVRPKhaKLVSLAVWLLVAALSAPVLSFSHLEVERHnKTECLGT------AV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVL--VLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMV-VFLLMWA----PYNIAFFLSTFKE 265
Cdd:cd15376 158 DSRLPTYLPYSLFLAVVgcGLPFLLTLASYLAIVWAVLRSPGITTLEKRKVAALVaVVVALYAvsfvPYHILRNLNLYRR 237
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 68215224 266 HFSlSDCKSSYNLDKSVHITKLIATTHCCINPLLYA 301
Cdd:cd15376 238 LQW-LKAAASLRIYFAYQVTKGLVTLNMCIHPLLYM 272
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
39-311 2.00e-13

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 69.78  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGlKRVENIYLLNLAVSNLCFLLTLPFW----AHAGGDPM----CKILIGLY 110
Cdd:cd15924   1 QLFPVLYTVIFFAGILLNGLAMWIFFHIPS-KSSFIIYLKNTVVADLLMILTFPFKilsdAGLGPWQLrtfvCRVTSVLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHkgNFFSAR-RRVPCGIITSVLAWVTAILATLPEFVVYKPQM-EDQKYKCAFSRTPF 188
Cdd:cd15924  80 YFTMYTSIVFLGLISIDRYLKIVR--PFKTSFpKSVSFAKILSVVVWALMFLLSLPNMILTNQQPrEKNVKKCSFLKSEL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 lpadeTFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL------RFREQ---RYSLFKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15924 158 -----GLKWHEIVNYICQVIFWIVFLLMIVCYTAITKKVyrsyrrVFRSSssrRKKSNVKIFIIVAVFFVCFVPYHFARI 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 260 LSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15924 233 PYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
48-302 2.47e-13

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 69.21  E-value: 2.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVkYKGLKRVEN-IYLLNLAVSNLCFLLTLPFWAHA-----GGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15164  10 ILFFGLLFNVLALWVFC-CKMKKWTETrVYMINLAVADCCLLFSLPFVLYFlkhswPDDELCLVLQSIYFINRYMSIYII 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVF---LHKGNFFSARRRVpcgiITSVLAWVTAILatlpeFVVYKPQMEDQKYKCAFSRTPFLPadetfwkH 198
Cdd:cd15164  89 TAIAVDRYIAIkypLKAKSLRSPRKAA----LTCGLLWVLVII-----SVSLRLAWEEQEENFCFGKTSTRP-------S 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLTLKMNISVLVLPLFIFTFLYVQ------MRKTLRFREQRysLFK----LVFAIMVVFLLMWAPYNIAFFLSTFKEHFS 268
Cdd:cd15164 153 KRTLIFSLLGFFIPLIILSFCSIQvirslkKKKKTNPHEEK--LIQkaiyIVSANLIVFIVCFLPLHIGLLVRFVMESNK 230
                       250       260       270
                ....*....|....*....|....*....|....
gi 68215224 269 LSdCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15164 231 AS-CSLIQNIRNFIYVASCLANANCCLDAICYYF 263
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
41-300 2.49e-13

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 69.44  E-value: 2.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF--------WAHAGGDPMCKiliGLYFV 112
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdlyrlwryRPWRFGDLLCR---LMYFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 glySETFFNC------LLTVQRYLVFLHKgnfFSARRRVPCGIITSVLA--WVTAILATLPEFVVYKPQMEDQkykcAFS 184
Cdd:cd15928  80 ---SETCTYAsilhitALSVERYLAICHP---LRAKVLVTRGRVKLLIAviWAVAIVSAGPALVLVGVEHIQG----QQT 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPFLPADETFWKHFLTLKMNISV--LVLPLFIFTFLYVQMRKTLRFREQRY-------------SLFKLVFAIMVVFLL 249
Cdd:cd15928 150 PRGFECTVVNVSSGLLSVMLWVSTsfFFVPMVCLSLLYGLIGRALWDRRQRSrtagasrrdnnhrQTVRMLAVIVLAFVL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 250 MWAPYNIA--FFLSTFKEHFSLSDCKSSYNLDKSVhitklIATTHCCINPLLY 300
Cdd:cd15928 230 CWLPFHVGrvIFNHSRASTKHLHYVSQYFNLVSFV-----LFYLSAAINPILY 277
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
56-311 3.49e-13

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 68.84  E-value: 3.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  56 NLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF-----------WAHagGDPMCKILIGLYFVGLYSETffNCL 123
Cdd:cd15204  18 NLLLIAVLARYKKLRTLTNLLIANLALSDfLVAVFCLPFemdyyvvrqrsWTH--GDVLCAVVNYLRTVSLYVST--NAL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 124 L--TVQRYLVFLHKGNfFSARRRVPCGIItsVLAWVTAILATLPEfVVYKPQMEDQKYKCAFSRTPFlPADETFWKHFLT 201
Cdd:cd15204  94 LviAIDRYLVIVHPLK-PRMKRRTACVVI--ALVWVVSLLLAIPS-AVYSKTTPYANQGKIFCGQIW-PVDQQAYYKAYY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 202 LKMNISVLVLPLFIFTFLYVQMRKTLRFRE------------QRYSLFK--LVFAIMVVFLLMWAPYNIAFFLSTFkehF 267
Cdd:cd15204 169 LFLFVLEFVLPVLIMTLCYLRIVRKVWFRRvpgqqteqirrrLRRRRRKvrLLVVILTAFVLCWAPYYGYAIVRDF---F 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 268 SLSDCKSSYNLDkSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15204 246 PTLLSKEKLNTT-IFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
46-307 3.58e-13

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 68.93  E-value: 3.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CF------LLTLPFWAHagGDPMCKILIGLYFVGL 114
Cdd:cd15392   8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDIlmavfCVpfsfiaLLILQYWPF--GEFMCPVVNYLQAVSV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYK----PQMEDQKYKCAfsrtpflp 190
Cdd:cd15392  86 FVSAFTLVAISIDRYVAIMWP---LRPRMTKRQALLLIAVIWIFALATALPIAITSRlfedSNASCGQYICT-------- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 adETFWKHFLTLKMNISVL----VLPLFIFTFLY------VQMRKT---------LRFREQRYSLFKLVFAIMVVFLLMW 251
Cdd:cd15392 155 --ESWPSDTNRYIYSLVLMilqyFVPLAVLVFTYtrigivVWAKRTpgeaennrdQRMAESKRKLVKMMITVVAIFALCW 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 252 APYNIaffLSTFKEHFSlsdckSSYNLDKSVHI---TKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15392 233 LPLNI---LNLVGDHDE-----SIYSWPYIPYLwlaAHWLAMSHCCYNPFIYCWMNAKF 283
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
47-311 3.63e-13

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 68.65  E-value: 3.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILvKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH--------AGGDPMCKILIGLYFVGLYSET 118
Cdd:cd15120   9 VTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVhvlmdnhwAFGTVLCKVLNSTLSVGMFTSV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLA-WVTAILATLPEFVVYKPQMEDQ-KYKCAFS---RTPFLPADE 193
Cdd:cd15120  88 FLLTAISLDRYLLTLHP--VWSRQHRTNRWASAIVLGvWISAILLSIPYLAFRETRLDEKgKTICQNNyalSTNWESAEV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVL----VLPLFIFTFLYVQMrkTLRFREQRYSL----FKLVFAIMVVFLLMWAPYNIAFFLSTFKE 265
Cdd:cd15120 166 QASRQWIHVAMFVFRFllgfLLPFLIITFCYVRM--ALKMKERGLARsskpFKVMFTAVVSFFVCWLPYHLHSGLVLTRG 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 68215224 266 HFSLSdckssynLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15120 244 RPPSL-------TDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
44-309 4.12e-13

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 68.57  E-value: 4.12e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILigLYFVGL- 114
Cdd:cd15206   6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQllrnfifGEVMCKLI--PYFQAVs 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCL-LTVQRYLVFLH-----KGNFFSARRRVPCGIITSVLAWVTAILAtlpeFVVYKPQMEDQKYKCAFsrtpF 188
Cdd:cd15206  84 VSVSTFTLVaISLERYFAICHplksrVWQTLSHAYKVIAGIWLLSFLIMSPILV----FSNLIPMSRPGGHKCRE----V 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPAD--ETFWKHFLTLKMnisvLVLPLFIFTFLYVQMRKTLRFREQRysLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEh 266
Cdd:cd15206 156 WPNEiaEQAWYVFLDLML----LVIPGLVMSVAYGLISWTLLEAKKR--VIRMLFVIVVEFFICWTPLYVINTWKAFDP- 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 267 fslsDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15206 229 ----PSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
44-311 5.84e-13

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 68.20  E-value: 5.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLilVKYKGLKR-VENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFV 112
Cdd:cd15114   6 LYAVVFLVGVPGNALVAW--VTGFEAKRsVNAVWFLNLAVADLLCCLSLPIlavpiaqdghWPF--GAAACKLLPSLILL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLH---KGNFFSARR-RVPCGIitsvlAWVTAILATLPEFVVYKPQME--DQKYKCAFSRt 186
Cdd:cd15114  82 NMYASVLLLTAISADRCLLVLRpvwCQNHRRARLaWIACGA-----AWLLALLLTVPSFIYRRIHQEhfPEKTVCVVDY- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 pflpADETFWKHFLTLKMNISVLVLPLFIFTFLY--VQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFK 264
Cdd:cd15114 156 ----GGSTGVEWAVAIIRFLLGFLGPLVVIASCHgvLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAAS 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 265 EHFSLSDCkssyNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15114 232 APNSRLLA----NALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
46-311 5.89e-13

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 68.21  E-value: 5.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15152   8 TVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLrifyylnksWPF--GKFLCMFCFYLKYVNMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSARRRvpCGIITSVLAWVTAILATLPeFVVYKpQMEDQKYKCAFSRTPFLPADETFW 196
Cdd:cd15152  86 SIYFLVCISVRRCLYLIYPFRYNDCKRK--CDVYISIAGWLVVCVGCLP-FPLLR-QSQDTNPTCCFADLPLRNVGLTTS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLKmNISVLVLPLFIFtfLYVQMRKTLRFRE---------QRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15152 162 VIMLTIA-ELTGFVTPLLIV--LYCSWKTVMSLREktpvlqdlgEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSN 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 268 SLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15152 239 KIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
48-307 8.28e-13

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 67.54  E-value: 8.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---------CFLLTLPFWAHAggdPMCKILIGLYFVGLYSET 118
Cdd:cd14989  10 LFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLilvadslieVFNLNEKYYDIA---VLCTFMSLFLQINMYSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRY--LVFLHKGNFFSARR--RVPCGIItsvlaWVTAILATLPEFVVYKPQMEDQKYKCafsrtpFLPADET 194
Cdd:cd14989  87 FFLTWMSFDRYiaLAKVMKSSPLRTMQhaRLSCGLI-----WMASISATLLPFTAVQAQHTGEVHFC------FADVREI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWKHfLTLKMNISVLVLPLFIFTFLYVQMR--KTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTF-KEHFSLSD 271
Cdd:cd14989 156 QWLE-VTLGFIIPFSIIGLCYSLIVRVLVRaqKHRRLRPRRQKALRMILVVVLVFFICWLPENVFISIQLLqGTQEPSES 234
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 272 CKSSYNLDKSV--HITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd14989 235 YDESFRHNHPLtgHIVNLAAFSNSCLNPLIYSFLGETF 272
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
49-311 2.22e-12

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 66.30  E-value: 2.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLLVVLIlVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFVGLYSET 118
Cdd:cd15119  11 FVLGVPGNAIVIWV-TGFKWKKTVNTLWFLNLAIADFVFVLFLPLhityvaldfhWPF--GVWLCKINSFVAVLNMFASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGnfFSARRRVPC-GIITSVLAWVTAILATLPeFVVYKPQMEdqkykCAFSRTPFLPADETFWK 197
Cdd:cd15119  88 LFLTVISLDRYISLAHPV--WSHRYRTLKsALILCGIVWLSAAAISGP-ALYFRDTME-----LSINVTICFNNFHKHDG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 HFLTLKMNISVLVLPLFIFTFLYVQMRKT---LRFREQRYSL------FKLVFAIMVVFLLMWAPYNIaFFLSTFKEHfs 268
Cdd:cd15119 160 DLIVMRHTILVWVRFFFGFLFPLLTMVVCyslLAIKVKRRTLlisskfFWTISAVIVAFFVCWTPYHI-FSILELSIH-- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 269 lSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15119 237 -HSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
48-311 2.87e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 66.20  E-value: 2.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLyfVGLYSETF 119
Cdd:cd15083  10 IGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMcILNCPLMVISSfsgrwifGKTGCDMYGFS--GGLFGIMS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FN--CLLTVQRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVY-KPQMEDQKYKCAFSRTPFLPADETFw 196
Cdd:cd15083  88 INtlAAIAVDRYLV-ITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWsRYVLEGLLTSCSFDYLSRDDANRSY- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 khflTLKMNISVLVLPLFIFTFLYV-------------------QMRKTLRFREQR----YSLFKLVFAIMVVFLLMWAP 253
Cdd:cd15083 166 ----VICLLIFGFVLPLLIIIYCYSfifravrrhekamkemakrFSKSELSSPKARrqaeVKTAKIALLLVLLFCLAWTP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 254 YNIAFFLSTFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15083 242 YAVVALIGQFGYLEVLTPLATA--------IPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
46-313 2.90e-12

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 65.72  E-value: 2.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILV-KYKGLKRVeNIYLLNLAVSNL--CFLLTLPFWA------HAGGDPMCKILIGLYFVGLYS 116
Cdd:cd15196   8 ATILVLALFGNSCVLLVLYrRRRKLSRM-HLFILHLSVADLlvALFNVLPQLIwdityrFYGGDLLCRLVKYLQVVGMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHK-GNFFSARRRVPCGIItsvLAWVTAILATLPE-FVVYKPQMEDQKYKCAFSRTP--FLPAD 192
Cdd:cd15196  87 SSYVLVATAIDRYIAICHPlSSHRWTSRRVHLMVA---IAWVLSLLLSIPQlFIFSYQEVGSGVYDCWATFEPpwGLRAY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWkhfltlkmNISVLVLPLFIFTFLYVQMRKTLrfREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSdc 272
Cdd:cd15196 164 ITWF--------TVAVFVVPLIILAFCYGRICYVV--WRAKIKTVKLTLVVVACYIVCWTPFFVVQMWAAWDPTAPIE-- 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 273 kssynlDKSVHITKLIATTHCCINPLLYAFldgtFSKYLCR 313
Cdd:cd15196 232 ------GPAFVIIMLLASLNSCTNPWIYLA----FSGNLRR 262
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
40-300 3.22e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 66.22  E-value: 3.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-FLLTLPF------WAH--AGGDPMCKiLIGLY 110
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPVelynfwWQYpwAFGDGGCK-LYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFN-CLLTVQRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLPEFVVYKPQMEDqkyKCAFSRTP 187
Cdd:cd14979  81 FEACTYATVLTiVALSVERYVAICHplKAKTLVTKRRV---KRFILAIWLVSILCAIPILFLMGIQYLN---GPLPGPVP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 ------FLPADETFWKHFLTlkMNISVLVLPLFIFTFLYVQMRKTLRFR---------------------EQRYSLFKLV 240
Cdd:cd14979 155 dsavctLVVDRSTFKYVFQV--STFIFFVLPMFVISILYFRIGVKLRSMrnikkgtraqgtrnvelslsqQARRQVVKML 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68215224 241 FAIMVVFLLMWAPYNIA--FFLSTFKEHFSLSDCKSSYNLdksvhITKLIATTHCCINPLLY 300
Cdd:cd14979 233 GAVVIAFFVCWLPFHAQrlMFSYASKEDTFLFDFYQYLYP-----ISGILFYLSSAINPILY 289
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
48-311 3.36e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 65.93  E-value: 3.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC----------FLLTLPFWAHagGDPMCKILIGLYFVGLYSE 117
Cdd:cd15012   9 VFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCvgifcvlqnlSIYLIPSWPF--GEVLCRMYQFVHSLSYTAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLH----KGNFFSARRRVpcgiiTSVLAWVTAILATLPEFVVYKpQMEDQKYKCAFSRTPFLPADE 193
Cdd:cd15012  87 IGILVVISVERYIAILHplrcKQLLTAARLRV-----TIVTVWLTSAVYNTPYFVFSQ-TVEILVTQDGQEEEICVLDRE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL---RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSls 270
Cdd:cd15012 161 MFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLwksSSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYR-- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 271 dCKSSYNLDKSVhITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15012 239 -CDSNWNALLTP-LTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
40-300 5.79e-12

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 65.20  E-value: 5.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLlVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYF 111
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNA-IILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHlngnnwvfGETMCRIITITFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVpCGIITSVLAWVTAILATLPeFVVYKPQMEDQK---YKCAFSRTPF 188
Cdd:cd15371  81 GNMYCSILLLTCISINRYLAIVHPFIYRSLPKKT-YAVLICALVWTIVFLYMLP-FFILKQTYYLKElniTTCHDVLPEC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFWKHFLTlkMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLF-KLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15371 159 EQNSNFQFYYFIS--MAVFGFLIPLVITIFCYISIIRTLNAYEHKWFWYvKITALVLIIFTICFAPSNVILIIHHFNYYY 236
                       250       260       270
                ....*....|....*....|....*....|...
gi 68215224 268 SLSDckssyNLDKSVHITKLIATTHCCINPLLY 300
Cdd:cd15371 237 FNND-----NLYSIYLIALCLGSLNSCLDPFLY 264
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
40-309 8.01e-12

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 64.82  E-value: 8.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15972   2 LIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNalsywpfGSFMCRLVMTVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNffSAR-RRVPCGIITSVLAWVTAILATLPefVVYKPQMEDQKYKCAFSrtpfLPA 191
Cdd:cd15972  82 NQFTSIFCLTVMSVDRYLAVVHPIR--SSKwRKPPVAKTVNATVWALSFLVVLP--VVIFSGVPGGMGTCHIA----WPE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFI----FTFLYVQMRKT--------LRFREQRYSLFKLVFAIMVVFLLMWAPY---NI 256
Cdd:cd15972 154 PAQVWRAGFIIYTATLGFFCPLLViclcYLLIVVKVRSSgrrvratsTKRRGSERKVTRMVVIVVAAFVLCWLPFyalNI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 257 AFFLSTFKEHFSLSDCKSsynldksvhITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15972 234 VNLVCPLPEEPSLFGLYF---------FVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
49-256 8.11e-12

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 64.59  E-value: 8.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLLVVLILVKYKGLKRVEN-IYLLNLAVSNLCFLLTLPFWAHAGGDPM--------CKILIGLYFVGLYSETF 119
Cdd:cd15170  11 FLIGLPANLLAFYTFIRKVRRKPTPIdILLLNLTVSDLIFLLFLPFKMAEAASGMiwplpyflCPLSSFIFFSTIYISTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYL--VFLHKgnfFSARRRVPCGIITSVLAWVTAIL-ATLPEFVVYKPQMEDQ----KYKCAfsrtpflpad 192
Cdd:cd15170  91 FLTAISVERYLgvAFPIK---YKLRRRPLYAVIASVFFWVLAFShCSIVYIVEYHIDSENTsvtnNSRCY---------- 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 193 ETFWKHFLT------LKMNISVLVLPLFIFTFLYVQMRKTLRF-----REQRYSLFKLVFAIMVVFLLMWAPYNI 256
Cdd:cd15170 158 DNFTPEQLKillpvrLELFLVLFCIPFLITCFCYINFIRILSSlphisRQRKQRAIGLAVATLLNFIVCFAPYNI 232
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
41-311 8.76e-12

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 64.93  E-value: 8.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLY 110
Cdd:cd15377   3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPAlifyyfnktdWIF--GDAMCKLQRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKGNFFsARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTpflp 190
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPLKSL-GRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTT---- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFL-TLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFK----------LVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15377 156 SDEYLRSYFIySMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENnaplrrksiyLVIIVLTVFAVSYLPFHVMKT 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 260 LST-FKEHFSLSD-CKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15377 236 LNLrARLDFQTPAmCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
46-307 9.36e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 64.88  E-value: 9.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL---TLPFWAHAGGDPMCKILIGLYF-VGLYSETFFN 121
Cdd:cd15357   8 AVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfgmPLEVYEMWSNYPFLFGPVGCYFkTALFETVCFA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLL-----TVQRYLVFLH--KGNFFSARRRvpcGIITSVLAWVTAILATLPEFVVYKPQMEdqkykcAFSRTPFLPADET 194
Cdd:cd15357  88 SILsvttvSVERYVAILHpfRAKLNSTRER---ALKIIVVLWVLSVLFSIPNTSIHGIKLQ------YFPNGTLIPDSAT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 ------FWKHFLTLKM-NISVLVLPLFIFTFLYVQMRKTLR--------------FREQRYSLFKLVFAIMVVFLLMWAP 253
Cdd:cd15357 159 ctvvkpLWIYNLIIQItSLLFYVLPMGVISVLYYLMGLKLRgdksleademnvniQRPSRKSVTKMLFVLVLVFAICWAP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 254 YNIAFFLSTFKEHFSLSdCKSSYNLdksVH-ITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15357 239 FHVDRLFFSFVVEWTEP-LANVFNL---IHvVSGVFFYLSSAVNPIIYNLLSRRF 289
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
40-311 1.26e-11

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 64.12  E-value: 1.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVE-NIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLY 110
Cdd:cd15925   2 LVALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPiDVFVFNLALADFGFALTLPFWAVESaldfhwpfGGAMCKMVLTAT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLH------KGNFFSARrrvpcgiITSVLAWVTAILATLPEfVVYKPQMEDQKYKCAFS 184
Cdd:cd15925  82 VLNVYASVFLLTAMSVTRYWVVASaagpgtHLSTFWAK-------IITLALWAAALLATVPT-AIFATEGEVCGVELCLL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPflpadETFWKHFLTLKMNISVLVLPLFIFTFLYV------QMRKTLRFREQRYSLF-KLVFAIMVVFLLMWAPYNIA 257
Cdd:cd15925 154 KFP-----SNYWLGAYHLQRVVVAFVVPLGVITTSYLlllsflQQHKVNQNNRQRQSVIaRSVRLVVASFFLCWFPNHVV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 258 FFLSTFKEHFSLSDCKSSYNLDKSVH-ITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15925 229 TFWGVLVKFRAVPWNSTFYFIHTYVFpVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
46-311 1.46e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 64.07  E-value: 1.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15395   8 SAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFtfvytlmdhWVF--GEAMCKLNSMVQCISIT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIitsVLAWVTAILATLPeFVVYK---------PQMEDQKYKCAFSRT 186
Cdd:cd15395  86 VSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGI---AVIWVLAVLTSLP-FLIFQvltdepfknVNVSLDAYKGKYVCL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFLPADEtfwkhfLTLKMNISVLVL----PL-FIFT-----FLYVQMRKTL--RFREQRY------SLFKLVFAIMVVFL 248
Cdd:cd15395 162 DQFPSDT------IRLSYTTCLLVLqyfgPLcFIFIcylkiYIRLKRRNNMmdKMRDNKYrssetkRINIMLISIVVAFA 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 249 LMWAPYNIafFLSTFK-EHFSLSDCksSYNLDKSV-HITKLIATthcCINPLLYAFLDGTFSKYL 311
Cdd:cd15395 236 VCWLPLNI--FNAVFDwNHEAIATC--NHNLLFLIcHLTAMIST---CVNPIFYGFLNKNFQRDL 293
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
40-307 2.67e-11

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 63.29  E-value: 2.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGL 109
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFtfvravnntWIF--GLFMCHFSNFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYK--PQMEDQKYKCAFSRTP 187
Cdd:cd15202  80 QYCSVHVSAYTLTAIAVDRYQAIMHP---LKPRISKTKAKFIIAVIWTLALAFALPHAICSKleTFKYSEDIVRSLCLED 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FLPADETFWKhFLTLKMNISVLVLPLFIFTFLYVQMRKTL------------RFREQRYS---LFKLVFAIMVVFLLMWA 252
Cdd:cd15202 157 WPERADLFWK-YYDLALFILQYFLPLLVISFAYARVGIKLwasnmpgdatteRYFALRRKkkkVIKMLMVVVVLFALCWL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 253 PYNIAFFLSTFKEhfslsdcKSSYNLDKSVHI-TKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15202 236 PFNIYVLLLSSKP-------DYLIKTINAVYFaFHWLAMSSTCYNPFIYCWLNERF 284
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-256 2.98e-11

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 63.28  E-value: 2.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF-----WAHAG---GDPMCKILIGLYFV 112
Cdd:cd15132   3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFdlyrlWKSRPwifGEFLCRLYHYISEG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLV--FLHKGNFFSARRRVPCGIitsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSR----T 186
Cdd:cd15132  83 CTYATILHITALSIERYLAicFPLRAKVLVTRRRVKCVI---AALWAFALLSAGPFLFLVGVEQDNNIHPDDFSReckhT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFlpADETFWKHFLtLKMNISVLVLPLFIFTFLYVQMRKTL--------------RFREQRYSLfKLVFAIMVVFLLMWA 252
Cdd:cd15132 160 PY--AVSSGLLGIM-IWVTTTYFFLPMLCLSFLYGFIGRKLwkskndlrgpnaaaRERSHRQTV-RILAVVVLAFIICWL 235

                ....
gi 68215224 253 PYNI 256
Cdd:cd15132 236 PFHI 239
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
75-315 3.30e-11

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 64.06  E-value: 3.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224   75 IYLLNLAVSNLCFLLTLPF-----WAHAGGDPM-CKILIGLYF----VGLYSETffncLLTVQRYLVfLHKGNFFSARRR 144
Cdd:PHA03235  71 LYMTNLYLANLLTVFVLPFimlsnQGLLSGSVAgCKFASLLYYasctVGFATVA----LIAADRYRV-IHQRTRARSSAY 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  145 VPCGIITSvLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTP---FLPADETF-----WKHFLTLKMNISVLVLPLFIF 216
Cdd:PHA03235 146 RSTYKILG-LTWFASLICSGPAPVYTTVVAHDDVDPEAPGYETcviYFRADQVKtvlstFKVLLTLVWGIAPVVMMTWFY 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  217 TFLYVQMRKTLRFREQRYSLFklVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSyNLDKSVH-ITKLIATTHCCI 295
Cdd:PHA03235 225 TFFYRTLKRASYKKRSRTLTF--VCILLLSFLCLQTPFVAIMIFDSYATLIWPSDCEHI-NLRDAVStLSRLVPNLHCLL 301
                        250       260
                 ....*....|....*....|
gi 68215224  296 NPLLYAFLDGTFSKYLCRCF 315
Cdd:PHA03235 302 NPILYAFLGNDFLKRFRQCF 321
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
41-309 4.17e-11

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 62.51  E-value: 4.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF--WAHAGGDP--MCKILIGLYFVGLYS 116
Cdd:cd15920   3 LPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFrvAYQNTAGPlsFCKIVGAFFYLNMYA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLPeFVVYKPQMEDQKYKCAFSRTPFLPADETfw 196
Cdd:cd15920  83 SILFLSLISLDRYLKIIKPLQQFKI-HTVPWSSAASGGVWLLLLACMIP-FLFESRNEGPCDNKCFHFRSKGLTAGGI-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 kHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSL------FKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd15920 159 -NLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKkaskraIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVIS 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15920 238 SLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
40-314 4.94e-11

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 62.27  E-value: 4.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF----------LLTLPFWAHagGDPMCKILIGL 109
Cdd:cd15299   5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgvismnlfttYIIMNRWAL--GNLACDLWLSI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSvLAWVTAilatlpeFVVYKPQMEDQKYkcaFSRTPFL 189
Cdd:cd15299  83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIG-LAWVIS-------FVLWAPAILFWQY---FVGKRTV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHF----LTLKMNISVLVLPLFIFTFLYVQMRKTlRFREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFKE 265
Cdd:cd15299 152 PPDECFIQFLsepiITFGTAIAAFYLPVTIMTILYWRIYKE-TIKEKKAA--QTLSAILLAFIITWTPYNIMVLVNTFCD 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 266 hfslsDC--KSSYNLDksvhitKLIATTHCCINPLLYAFLDGTFSK-----YLCRC 314
Cdd:cd15299 229 -----SCipKTYWNLG------YWLCYINSTVNPVCYALCNKTFRTtfkmlLLCQC 273
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
44-307 5.33e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 62.65  E-value: 5.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKyKGLKRVENIYLLNLAVSNLCFLLT--LPFWAHAGGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSalPLFLLPYIADYSSSFLSYFYAYFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 -----------CLLTVQRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLPEFVVYK--PQMEDQKYKCAFSRT 186
Cdd:cd14978  85 ntfqtasvwltVALTVERYIAVCHplKARTWCTPRRA---RRVILIIIIFSLLLNLPRFFEYEvvECENCNNNSYYYVIP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFLPADETFWKHFLTLKMNISVLVLPLFIFTFL----YVQMRKTLRFREQRY--------------SLFKLVFAIMVVFL 248
Cdd:cd14978 162 TLLRQNETYLLKYYFWLYAIFVVLLPFILLLILnillIRALRKSKKRRRLLRrrrrllsrsqrrerRTTIMLIAVVIVFL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 249 LMWAPYNIAFFLSTFKEHFSLsdcksSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd14978 242 ICNLPAGILNILEAIFGESFL-----SPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKF 295
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
41-311 7.53e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 62.05  E-value: 7.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd14977   3 IMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLltkdwlfGDVMCKLVPFIQVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLhkgnffSARRRVPCGIITSVLA-----WVTAILATLPEFVVYK-PQMEDQK--YKCAFS 184
Cdd:cd14977  83 SLGVTVFSLCALSIDRYRAAV------NSMPMQTIGACLSTCVklaviWVGSVLLAVPEAVLSTvARESSLDnsSLTVCI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR-----------EQRYSLFKLVFAIMVVFLLMWAP 253
Cdd:cd14977 157 MKPSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAkeytrgtkkhmKQRRQLAKTVLCLVLVFAFCWLP 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 254 YNIAFFLSTFkeHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14977 237 EHISNILRAT--LYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
46-300 7.80e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 62.07  E-value: 7.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---CF-LLTLPFWAHA----GGDPMCKILIGLYFVGLYSE 117
Cdd:cd15384   8 AVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLlvtFFcIPSEAIWAYTvawlAGNTMCKLVKYLQVFGLYLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItsvLAWVTAILATLPEFVVY----KPQMEDqKYKCAFSRTPFLPADE 193
Cdd:cd15384  88 TYITVLISLDRCVAILYPMKRNQAPERVRRMVT---VAWILSPIFSIPQAVIFhverGPFVED-FHQCVTYGFYTAEWQE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMnisvLVLPLFIFTFLYVQMRKTLR-----------------------FREQRYSLFKLVFAIMVVFLLM 250
Cdd:cd15384 164 QLYNMLSLVFM----FPIPLVIMVTCYVLIFITLSkssrdfqgleiytrnrgpnrqrlFHKAKVKSLRMSAVIVTAFILC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 68215224 251 WAPYNIAFFLSTFKEHFSLSdckssynlDKSVHITKLIATTHCCINPLLY 300
Cdd:cd15384 240 WTPYYVIMIWFLFFNPYPLN--------DILFDVIFFFGMSNSCVNPLIY 281
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
43-305 7.83e-11

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 62.15  E-value: 7.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKY-KGLKR----VENIYLLNLAVS------NLCFLLTLPFWahaGGDPMCKILIGLYF 111
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTkKKASRmhlfIKHLSLADLVVAffqvlpQLCWDITYRFY---GPDFLCRIVKHLQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSvlAWVTAILATLPEFVVY---KPQMEDQKYKCafsrtpf 188
Cdd:cd15385  82 LGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGS--AWALSFILSTPQYFIFslsEIENGSGVYDC------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 lpadetfWKHFLTLK--------MNISVLVLPLFIFTFLY----------VQMRKTLRFREQRYSLF------------- 237
Cdd:cd15385 153 -------WANFIVPWgikayitwITISIFVVPVIILLTCYgficyniwrnIKCKTRRGLSDNALKNIllavcvssvktis 225
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 238 -------KLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDckssyNLDKSVHITKLIATTHCCINPLLYAFLDG 305
Cdd:cd15385 226 rakirtvKMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDE-----SENTAVTITALLASLNSCCNPWIYMFFSG 295
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
45-300 9.82e-11

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 61.82  E-value: 9.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  45 CSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP-----FWAHAG---GDPMCKILIGLYFVGLYS 116
Cdd:cd15131   7 CVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPldlyrLWQYRPwnfGDLLCKLFQFVSESCTYS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLV--FLHKGNFFSARRRVPCGIItsvLAWVTAILATLPEFVVYKPQMEDQKYKcaFSRTPFLPADET 194
Cdd:cd15131  87 TILNITALSVERYFAicFPLRAKVVVTKRRVKLVIL---VLWAVSFLSAGPIFVLVGVEHENGTNP--IDTNECKATEYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWKHFLTLKMNIS--VLVLPLFIFTFLYVQMRKTLRFREQRYSL-------------FKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15131 162 VRSGLLTIMVWVSsvFFFLPVFCLTVLYSLIGRKLWRRRRENIGpnashrdknnrqtVKMLAVVVFAFVLCWLPFHVGRY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 260 LstfkehFSLSDCKSSYNLDKSVHITKLIATT----HCCINPLLY 300
Cdd:cd15131 242 L------FSKSFEAGSLEIALISQYCNLVSFVlfylSAAINPILY 280
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
40-302 1.21e-10

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 61.55  E-value: 1.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGL 109
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFyipytltgkWPF--GKVFCKAWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVfLHKGNFFSAR---RRVPCGIITSvlaWVTAILATLPEFVVYKPQME---DQKYKCaf 183
Cdd:cd15048  80 DYTLCTASALTIVLISLDRYLS-VTKAVKYRAKqtkRRTVLLMALV---WILAFLLYGPAIIGWDLWTGysiVPTGDC-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 srtpflpaDETFWKHF-LTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRY---------------------SLFKLVF 241
Cdd:cd15048 154 --------EVEFFDHFyFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRplrsvpilpasqnpsrarsqrEQVKLRR 225
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 242 --------AIMV-VFLLMWAPYNIAFFLSTFkehfslsdCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15048 226 drkaakslAILVlVFLICWAPYTILTIIRSF--------CSGSCVDSYLYEFTFWLLWTNSAINPFLYAA 287
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
46-311 1.97e-10

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 60.90  E-value: 1.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVkYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15117   8 SSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAFCLFLPFsvvytalgfhWPF--GWFLCKLYSTLVVFNLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKgnfFSAR--RRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpFLPADE 193
Cdd:cd15117  85 ASVFLLTLISLDRCVSVLWP---VWARnhRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLN---FDPWNE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVL------------VLPLFIFTFLYVQMRKTLRFREQRYSL--FKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15117 159 TAEDPVLWLETVVQRLsaqvitrfvlgfLVPLVIIGGCYGLIAARLWREGWVHSSrpFRVLTAVVAAFFLCWFPFHLVSL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 260 LSTfkehFSLSDCKSSYN--LDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15117 239 LEL----VVILNQKEDLNplLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
44-307 2.35e-10

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 60.61  E-value: 2.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYFVG 113
Cdd:cd15391   6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMaLFCMPFtftqimlghWVF--PAPMCPIVLYVQLVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItsvLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADE 193
Cdd:cd15391  84 VTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIA---SIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TfWKHFLTLKMNISVLVLPLFIFTFLYV----------------QMRKTLRFREQRYSLFKLVFaIMVVFLLMWAPYNIA 257
Cdd:cd15391 161 T-SRSAYTVFVMLLTYIIPLLILTSTYGyvgfrlwnrtapgnadKGRDDMQIKSKRKVIKMLVF-VVLMFGICWLPLHLF 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 258 FFLSTFKEHFSlsdckssynlDKSVHITKL-------IATTHCCINPLLYAFLDGTF 307
Cdd:cd15391 239 NLVQDFSTVFR----------NMPQHTTRLiygachwIAMSNSFVNPIIYLFMNDSF 285
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
44-307 2.40e-10

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 60.48  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL-----TLPFWAHAG-----GDPMCKILIGLYFVG 113
Cdd:cd14995   6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVaaglpNEIESLLGPdswiyGYAGCLLITYLQYLG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIITsvlAWVTAILATLPEF--VVYKPQMEDQKY--KCAF--SR 185
Cdd:cd14995  86 INASSLSITAFTIERYIAICHpmKAQFICTVSRAKKIICF---VWIFTSLYCSPWLflLDLSIKHYGDDIvvRCGYkvSR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 TPFLP---ADETFWkhfltlkmnisvLVLPLFIFTFLYVQMRKTLrfREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLST 262
Cdd:cd14995 163 HYYLPiylADFVLF------------YVIPLLLAIVLYGLIGRIL--FSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNS 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 263 FkehfslsdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd14995 229 F--------ASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKF 265
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
50-311 3.09e-10

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 60.39  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC--FLLTLPFWAHAG------GDPMCKIL----IGLYFVGLYSE 117
Cdd:cd15390  12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLisAFNTVFNFTYLLyndwpfGLFYCKFSnfvaITTVAASVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TffncLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFV-----VYKPQMEDQKYKCAFSrtpfLPAD 192
Cdd:cd15390  92 M----AISIDRYIAIVHP---LRPRLSRRTTKIAIAVIWLASFLLALPQLLystteTYYYYTGSERTVCFIA----WPDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVL-VLPLFIFTFLYVQMRKTLRFRE------QRY--------SLFKLVFAIMVVFLLMWAPYNIA 257
Cdd:cd15390 161 PNSLQDFVYNIVLFVVTyFLPLIIMAVAYTRVGVELWGSKtigentPRQlesvrakrKVVKMMIVVVVIFAICWLPYHLY 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 258 FFLSTFKEhfslsdckSSYNLDKSVHI---TKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15390 241 FILTYLYP--------DINSWKYIQQIylaIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
40-305 8.96e-10

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 58.62  E-value: 8.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGL 109
Cdd:cd16001   2 LLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLlivnyamrdrWPF--GDFLCKLVRFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPfl 189
Cdd:cd16001  80 FYTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTR-RLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSP-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 padETFWKHFL-TLKMNISVLVLPLFIFTFLYVQMRKTLRFREQ--------RYSLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd16001 157 ---DNFGNYFPyGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEaagvgkaaRAKSIRTILLVCGLFALCFVPFHITRTI 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYaFLDG 305
Cdd:cd16001 234 YLFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLY-FLSG 277
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
40-309 9.74e-10

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 58.68  E-value: 9.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKY-KGLKRVENIYLLNLAVSNLCFLL-TLPFWAH-------AGGDPMCKILIGLY 110
Cdd:cd15097   2 IVPVVFSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILfCVPFQATiyslegwVFGSFLCKAVHFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSV-LAWVTAILATLPEFVVYKPQMEDQKYKCafsrtpfL 189
Cdd:cd15097  82 YLTMYASSFTLAAVSVDRYLAIRYP--LRSRELRTPRNAVAAIaLIWGLSLLFAGPYLSYYDLIDYANSTVC-------M 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVqmrKTLRF--------------REQRYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd15097 153 PGWEEARRKAMDTCTFAFGYLIPVLVVSLSYT---RTIKYlwtavdpleamsesKRAKRKVTKMIIIVTALFCLCWLPHH 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 256 iAFFLSTFKEHFSLSDCKSSYNLdksvhITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15097 230 -VVILCYLYGDFPFNQATYAFRL-----LSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
43-307 1.04e-09

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 58.43  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---CFLLTLPF-------WAHagGDPMCKiLIGLYFV 112
Cdd:cd15210   5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLlfcAFNLPLAAstflhqaWIH--GETLCR-VFPLLRY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFN-CLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpFLPA 191
Cdd:cd15210  82 GLVAVSLLTlVLITLNRYILIAHPSLYPRIYTR-RGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCS---ILRD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETfwKHFLTLKMNISVlVLPLFIFTFLYvqmrktlrFREQRYSLFKLVFAIMVVFLLMWAPYNIAfflstfkehfSLSD 271
Cdd:cd15210 158 KKG--RSPKTFLFVFGF-VLPCLVIIICY--------ARREDRRLTRMMLVIFLCFLVCYLPITLV----------NVFD 216
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 68215224 272 CKSSYnldKSVHITKLIAT-THCCINPLLYAFLDGTF 307
Cdd:cd15210 217 DEVAP---PVLHIIAYVLIwLSSCINPIIYVAMNRQY 250
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
41-309 1.06e-09

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 58.50  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF----------LLTLPFWAHagGDPMCKILIGLY 110
Cdd:cd15300   3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIgifsmnlytsYILMGYWAL--GSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSvLAWVTAilatlpeFVVYKPQMEDQKYkcaFSRTPFLP 190
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIG-LAWLIS-------FILWAPPILCWQY---FVGKRTVP 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADET----FWKHFLTLKMNISVLVLPLFIFTFLYVQM-RKTLRFREQRYSLFklvfAIMVVFLLMWAPYNIAFFLSTFke 265
Cdd:cd15300 150 ERECqiqfLSEPTITFGTAIAAFYIPVSVMTILYCRIyKETIKERKAAQTLS----AILLAFIITWTPYNIMVLVSTF-- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 266 hfsLSDCKSSynldKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15300 224 ---CSDCIPL----TLWHLGYWLCYVNSTVNPMCYALCNKTFRK 260
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
47-307 1.92e-09

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 57.80  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP---FWAHAG-----GDPMCKILIGLYFVGLYSET 118
Cdd:cd15161   9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPmrlVYHLSGnhwpfGEVPCRLAGFLFYLNMYASL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVYKPQMEDQKYKCafsrtpflpadETFWKH 198
Cdd:cd15161  89 YFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFL-WVIVTVAMAPLLVSPQTVEVNNTTVC-----------LQLYRE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLTLKMNISVLV---LPLFIFTFLYVQMRKTLR--FREQRY---SLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd15161 157 KASRGALVSLAVaftIPFVTTVTCYLLIIRSLRtgKREEKPlkdKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGA 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 68215224 271 DCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15161 237 SCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKF 273
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-305 2.02e-09

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 57.84  E-value: 2.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF--WAHAGGD------PMCKILIGLYF 111
Cdd:cd15373   2 LLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLlvYYYADENdwpfseALCKIVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLPE-FVVYKPQMEDqkykcafSRTPFLP 190
Cdd:cd15373  82 TNLYCSILFLLCISVHRFLGVCYPVRSLRW-LKVRYARIVSVVVWVIVLACQSPVlYFVTTSDKGG-------NITCHDT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLV--LPLFIFTFLYVQMRKTL--------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15373 154 SSPELFDQFVVYSSVMLVLLfcVPFVVILVCYALMVRKLlkpsagtsTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 261 STFKEHFSLSdCKSSYNLDKSVHITKLIATTHCCINPLLYaFLDG 305
Cdd:cd15373 234 YYSFRSMDLS-CGTLNAINLAYKVTRPLASANSCLDPILY-FLAG 276
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
46-302 2.21e-09

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 57.48  E-value: 2.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWA------H--AGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15364   8 SVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTiyvsnnHkwPWGSLACKITGYIFFCNIYIS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATlPEFVVYKPQMEDQKykcafsrTPF--LPADETF 195
Cdd:cd15364  88 ILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHS-PVFIMREGQTEGSH-------TCFetLQMDTQV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFIFT----FLYVQMRKTLRFReQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFkeHFSL-- 269
Cdd:cd15364 160 AGFYYARFCIGFAIPLAILIFTnyriFRSIQTSTSLTPH-QKAKVKYLAIAVIVIFLICFAPYHLVLLVRAI--AFSLyp 236
                       250       260       270
                ....*....|....*....|....*....|....
gi 68215224 270 -SDCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd15364 237 nGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVL 270
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
44-309 2.80e-09

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 57.48  E-value: 2.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WahAGGDPMCKILIGLYFVG 113
Cdd:cd15205   6 TYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFtllqnissnW--LGGAFMCKMVPFVQSTA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLH--KGNFFSARRRvpcGIITSVLAWVTAILATLPEFVVYKPQ-----MEDQKYKCAFSRT 186
Cdd:cd15205  84 VVTSILTMTCIAVERHQGIVHplKMKWQYTNRR---AFTMLGLVWIVSVIVGSPMLFVQQLEvkydfLYEKRHVCCLERW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 pflpADETFWKHFLTLKMNIsVLVLPLFIFTFLYVQ------------------------MRKTLRFREQRyslFKLVFA 242
Cdd:cd15205 161 ----YSPTQQKIYTTFILVI-LFLLPLTTMLFLYSRigyelwikkrvgdasvlqtihgieMSKISRKKKRA---VKMMVT 232
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 243 IMVVFLLMWAPYNIAFFLstfkehFSLSDCKSSYNlDKSVHIT----KLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15205 233 VVLLFAVCWAPFHVVHMM------IEYSNLENKYD-GVTIKLIfaivQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
46-311 2.81e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 57.33  E-value: 2.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-------LLTLP----FWAHagGDPMCKI--LIGLYFv 112
Cdd:cd15337   8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFsavngfpLKTISsfnkKWIW--GKVACELygFAGGIF- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFnCLLTVQRYLVFLHK-GNFFSARRRVPCGIItsVLAWVTAILATLPEFVVY-KPQMEDQKYKCAFSrtpFLP 190
Cdd:cd15337  85 GFMSITTL-AAISIDRYLVIAKPlEAMKKMTFKRAFIMI--IIIWLWSLLWSIPPFFGWgRYVPEGFQTSCTFD---YLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADetfWKHFL-TLKMNISVLVLPLFIFTFLYVQMRKTLRFREQ---------------------RYSLF--KLVFAIMVV 246
Cdd:cd15337 159 RD---LNNRLfILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKemtqtaksgmgkdtekndarkKAEIRiaKVAIILISL 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 247 FLLMWAPYNIAFFLSTFKEHFSLSDCKSsynldksvHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15337 236 FLLSWTPYAVVALLGQFGPAYWITPYVS--------ELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
50-309 2.84e-09

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 57.23  E-value: 2.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-----FLLTLPFWAHAG---GDPMCKI---LIGLYFVGlyseT 118
Cdd:cd15401  12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvavypYPLILLAIFHNGwtlGNIHCQIsgfLMGLSVIG----S 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFN-CLLTVQRYLVFLH--KGNFFSARRRVPCGIitsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadetf 195
Cdd:cd15401  88 VFNiTAIAINRYCYICHslRYDKLYNMKKTCCYV---CLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTV-------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 wKHFLTLKMNISVLVLPLFIFTFLY-------VQMRKTLR------FREQRYSLFKLVFAIMVVFLLMWAPYN-IAFFLS 261
Cdd:cd15401 157 -SSSYTITVVVVHFIVPLSIVTFCYlriwvlvIQVKHRVRqdskqkLKANDIRNFLTMFVVFVLFAVCWGPLNfIGLAVA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 68215224 262 TFKEHFSLSDCKSSYNLdksvhiTKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15401 236 INPLKVAPKIPEWLFVL------SYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
39-311 3.18e-09

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 57.16  E-value: 3.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVkYKGLKRVENIYLLNLAVSNLCFLLTLPF--WAHAGGDP------MCKILIGLY 110
Cdd:cd15149   1 RVIPVFYSLVFIVGILLNGVNFWIFF-YVPSNKSFIVYLKNIVFADLLMSLTFPFkiLSDVELGPwqlnviVCRYSAVIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLhKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVY-KPQMEDQKYKCAFsrtpfL 189
Cdd:cd15149  80 YLNMYVGIIFFGLIGFDRYYKIV-KPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTnQSFHEANYTKCAR-----L 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYS---------LFKLVFAIMVVFLLMWAPYNIA--- 257
Cdd:cd15149 154 KSELGIQWHKASNYICVSIFWVVFLLLIIFYVAISRKIYKSNQKFRrnstnmkakSSRNIFSILFVFFVCFVPYHALrip 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 258 FFLSTFKEHFSlsdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15149 234 YTLSQTGADYS---CQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-309 3.26e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 57.10  E-value: 3.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-----FLLTLPFWAHAG---GDPMCKI---LIGLYFVGlyseT 118
Cdd:cd15209  12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvaiypYPLILHAIFHNGwtlGQLHCQAsgfIMGLSVIG----S 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCL-LTVQRYLVFLHKGNF--FSARRRVPCGIitsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadetf 195
Cdd:cd15209  88 IFNITaIAINRYCYICHSLQYdrLYSLRNTCCYL---CLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTV-------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 wKHFLTLKMNISVLVLPLFIFTFLYV-------QMRKTLRfREQRYSL-------FKLVFAIMVVFLLMWAPYNIAFFLs 261
Cdd:cd15209 157 -STVYTITVVVIHFLLPLLIVSFCYLriwvlvlQVRQRVK-PDQRPKLkpadvrnFLTMFVVFVLFAVCWAPLNFIGLA- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 262 tfkehFSLSDCKSSYNLDKSVHITK-LIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15209 234 -----VAINPKEMAPKIPEWLFVASyFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-307 3.34e-09

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 57.25  E-value: 3.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-----LLTLPFWAHAG---GDPMCKIL----IGLYFVG 113
Cdd:cd16003   8 GFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMaafntLINFIYALHSEwyfGEAYCRFHnffpITSVFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETffncLLTVQRYLVFLH--KGNFFSARRRVPCGIItsvlaWVTAILATLPEFVVYKPQMEDQKYKC--AFSRTPfl 189
Cdd:cd16003  88 IYSMT----AIAVDRYMAIIDplKPRLSATATKVVIGSI-----WILAFLLAFPQCLYSKTKVMPGRTLCfvAWPGGP-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 paDETFWKHFLTLkmnISVLVLPLFIFTFLYVQMRKTL-----------RFREQ---RYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd16003 157 --DQHFTYHIIVI---VLVYCLPLLVMGITYTIVGITLwggeipgdtsdKYHEQlraKRKVVKMMIIVVLTFAICWLPYH 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 256 IAFFLSTFKEHFslsdckSSYNLDKSVHITKL-IATTHCCINPLLYAFLDGTF 307
Cdd:cd16003 232 IYFIVTGLYQQL------NRWKYIQQVYLASFwLAMSSTMYNPIIYCCLNKRF 278
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
40-311 5.07e-09

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 56.67  E-value: 5.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTLPF-WAHAG---GDPMCKILIGLY 110
Cdd:cd15394   2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMlmcatCVPLTLAYaFEPRGwvfGRFMCYFVFLMQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHkgnffSARRRVPCGIITSVLA--WVTAILATLPEFV--VYKPQMEDQKYKCafsrt 186
Cdd:cd15394  82 PVTVYVSVFTLTAIAVDRYYVTVY-----PLRRRISRRTCAYIVAaiWLLSCGLALPAAAhtYYVEFKGLDFSIC----- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 pflpadETFWKH------FLTLKMNISVLVLPLFIFTFLYVQMRKTLRFR---------------EQRYSLFKLVFAIMV 245
Cdd:cd15394 152 ------EEFWFGqekqrlAYACSTLLITYVLPLLAISLSYLRISVKLRNRvvpgsmtqsqaewdrARRRKTFRLLVVVVV 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 246 VFLLMWAPYNIAFFLSTFKEHFSlsdCKSSYNLDK-SVHitkLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15394 226 AFAICWLPLHIFNVIRDIDIDLI---DKQYFNLIQlLCH---WLAMSSACYNPFLYAWLHDSFRGEL 286
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
46-304 7.04e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 55.90  E-value: 7.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF--------WAHAGGDPMCKILIGLYFVGLYSE 117
Cdd:cd14964   6 SLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVlffllgltEASSRPQALCYLIYLLWYGANLAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVykpqmedqkyKCAFSRTPFLPADE--TF 195
Cdd:cd14964  86 IWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGC-WGVSLLLSIPPLVG----------KGAIPRYNTLTGSCylIC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRY------------SLFKLVFAIMVVFLLMWAPYNIAFFLstf 263
Cdd:cd14964 155 TTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIrsaaslntdknlKATKSLLILVITFLLCWLPFSIVFIL--- 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 68215224 264 keHFSLSDCKSSYNLdksVHITKLIATTHCCINPLLYAFLD 304
Cdd:cd14964 232 --HALVAAGQGLNLL---SILANLLAVLASTLNPFIYCLGN 267
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
39-309 9.60e-09

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 55.59  E-value: 9.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH-------AGGDPMCKILIGLYF 111
Cdd:cd15121   1 QLGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHflsgggwEFGSVVCKLCHYVCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKgnFFSARRRVPCGIITSVLA-WVTAILATLPEFVVYKPQMEDQKYKCAFSRTPfLP 190
Cdd:cd15121  81 VSMYASIFLITLMSMDRCLAVAKP--FLSQKMRTKRSVRALLLAiWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHP-SV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFwkHFLTLKMNISVLVLPLFIFTFLYVQMR-KTLRFREQRYSlFKLVFAIMVVFLLMWAPYNIAFFLSTFKehfSL 269
Cdd:cd15121 158 GHEAF--QYLFETITGFLLPFTAIVTCYSTIGRRlRSARFRRKRRT-NRLVVLIIATFALFWLPYHVVNLIQVAG---AL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 270 SDCKSSYNLDKSVHITKLIATT----HCCINPLLYAFLDGTFSK 309
Cdd:cd15121 232 QNQAGNASVLKAAKLARPNVTAlaflSSSVNPVLYAFAGGSLIR 275
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
46-311 1.06e-08

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 55.61  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPFWAHAG-------GDPMCKILIGLYFVGLYSE 117
Cdd:cd15396   8 SVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDvLVCVMCIPFTAVYTlmdhwifGETMCKLTSFVQSVSVSVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIitsVLAWVTAILATLPEFVVYkpQMEDQKYKCAFSRTPFLPADETFWK 197
Cdd:cd15396  88 IFSLVLIAIERYQLIVNPRGWKPSASHAYWGI---VLIWLFSLMISIPFLIFH--QLTDEPFRNLSSHSDFYKDKVVCIE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 HFLT----LKMNISVLVLPLF------------IFTFLYVQMRKTLRFREQRYSLFK------LVFAIMVVFLLMWAPYN 255
Cdd:cd15396 163 AWPSeterLIFTTSLLVFQYFvplgfificylkIFVCLKKRNSKIDRMRENESRLSEnkrintMLISIVVTFAACWLPLN 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 256 IafFLSTFK-EHFSLSDCksSYNLdkSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15396 243 I--FNVVFDwNHEVLMSC--HHNL--VFTLCHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
50-301 1.29e-08

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 55.13  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWA----HAG---GDPMCKILIGL-YFVGLYSETFF 120
Cdd:cd15073  12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVsIIGYPFSAasdlHGSwkfGYAGCQWYAFLnIFFGMASIGLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 121 NClLTVQRYLVFLHK--GNFFSARRRvpcgIITSVLAWVTAILATLPEFVVYkpqmedqkykCAFSRTPFLPADETFWKH 198
Cdd:cd15073  92 TV-VAVDRYLTICRPdlGRKMTTNTY----TVMILLAWTNAFFWAAMPLVGW----------ASYALDPTGATCTINWRK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 ----FLTLKMNISVL--VLPLFIFTFLYVQMRKTLR--------------FREQRySLFKLVFAIMVVFLLMWAPYNIAF 258
Cdd:cd15073 157 ndssFVSYTMSVIVVnfIVPLAVMFYCYYNVSRFVKkvlasdclesvnidWTDQN-DVTKMSVIMIVMFLVAWSPYSIVC 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 259 FLSTFKEHfslSDCKSSYNLdksvhITKLIATTHCCINPLLYA 301
Cdd:cd15073 236 LWASFGEP---KKIPPWMAI-----IPPLFAKSSTFYNPCIYV 270
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
40-309 1.57e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 55.03  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---CFLLTL-------PFWAHagGDPMCKILIGL 109
Cdd:cd15298   2 FIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLiigAFSMNLytvyiikGYWPL--GAVVCDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILATLP-----EFVVYKPQMEDQKYKCAFS 184
Cdd:cd15298  80 DYVVSNASVMNLLIISFDRYFC-VTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPailfwQFVVGKRTVPDNQCFIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPFLpadetfwkhflTLKMNISVLVLPLFIFTFLYVQMrKTLRFREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFk 264
Cdd:cd15298 159 SNPAV-----------TFGTAIAAFYLPVVIMTVLYIHI-SLASARERKVT--RTIFAILLAFILTWTPYNVMVLVNTF- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 265 ehfslsdCKSSYNlDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15298 224 -------CQSCIP-DTVWSIGYWLCYVNSTINPACYALCNATFKK 260
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
40-309 1.62e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 54.97  E-value: 1.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGvldNLLVVLILVKYKGLKRVENIYLLNLAVSNL----CFLLTLPFWAHAGGDPM----CKILIGLYF 111
Cdd:cd15297   5 LVAGSLSLVTIIG---NILVMVSIKVNRHLQTVNNYFLFSLACADLiigvFSMNLYTLYTVIGYWPLgpvvCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVlAWVTAilatlpeFVVYKPQMEDQKYKCAfSRTpfLPA 191
Cdd:cd15297  82 VVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAA-AWVLS-------FILWAPAILFWQFIVG-GRT--VPE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHF----LTLKMNISVLVLPLFIFTFLYVQMRKTlRFREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFkehf 267
Cdd:cd15297 151 GECYIQFFsnaaVTFGTAIAAFYLPVIIMTVLYWQISRA-SSREKKVT--RTILAILLAFIITWTPYNVMVLINTF---- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 268 sLSDCkssynLDKSV-HITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15297 224 -CASC-----IPNTVwTIGYWLCYINSTINPACYALCNATFKK 260
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
50-255 1.76e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 54.91  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-----FLLTLPFWAHAG---GDPMCKI---LIGLYFVGlyseT 118
Cdd:cd15402  12 VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVvaiypYPLVLTSIFHNGwnlGYLHCQIsgfLMGLSVIG----S 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCL-LTVQRYLVFLHKGNF---FSARRRVpCGIItsvLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadet 194
Cdd:cd15402  88 IFNITgIAINRYCYICHSLKYdklYSDKNSL-CYVL---LIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSV------- 156
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68215224 195 fwKHFLTLKMNISVLVLPLFIFTFLY-------VQMRKTL------RFREQRYSLFKLVFAIMVVFLLMWAPYN 255
Cdd:cd15402 157 --SSAYTIAVVFFHFILPIIIVTFCYlriwilvIQVRRRVkpdnkpKLKPHDFRNFVTMFVVFVLFAVCWAPLN 228
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
40-305 1.84e-08

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 54.81  E-value: 1.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP----FWAHAG----GDPMCKILIGLYF 111
Cdd:cd15374   2 LLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtliyYYADHNhwpfGVVACKIVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpa 191
Cdd:cd15374  82 ANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLIC-ASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 dETFwKHFLTLKMNISVLV--LPLFIFTFLYVQMRKTL----------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15374 157 -EEF-DHYVHYSSAVMVLLfgIPCLVIVVCYGLMARRLckprvgssrqQGPSSKKRSLKTIIMVLTVFAICFVPFHITRT 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 68215224 260 LSTFKEHFSlSDCKSSYNLDKSVHITKLIATTHCCINPLLYaFLDG 305
Cdd:cd15374 235 LYYVARLLK-ADCDTLNIINVTYKVTRPLASANSCLDPILY-FLAG 278
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
43-277 2.29e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 54.17  E-value: 2.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFV 112
Cdd:cd15323   5 AVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADiLVATLVMPFslanelmgyWYF--GQVWCNIYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFFSAR--RRVPcGIITSVlaWVTAILATLPEFVVYKPQMEDQKY-KCAFSrtpfl 189
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRtpRRVK-AIIVTV--WLISAVISFPPLISMYRDPEGDVYpQCKLN----- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 paDETFWkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVfaIMVVFLLMWAPYNIAFFL--------- 260
Cdd:cd15323 155 --DETWY----ILSSCIGSFFAPCLIMILVYIRIYRVAKAREKRFTFVLAV--VMGVFVVCWFPFFFSYSLygicreace 226
                       250       260
                ....*....|....*....|
gi 68215224 261 ---STFKEHFSLSDCKSSYN 277
Cdd:cd15323 227 vpePLFKFFFWIGYCNSSLN 246
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
50-256 2.61e-08

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 54.47  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-----FLLTLPFWAHAG---GDPMCKI---LIGLYFVGlyseT 118
Cdd:cd15400  12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVvalypYPLVLVAIFHNGwalGEMHCKVsgfVMGLSVIG----S 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCL-LTVQRYLVFLHK---GNFFSARRRvpcgIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadet 194
Cdd:cd15400  88 IFNITgIAINRYCYICHSfayDKLYSRWNT----LLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTA------- 156
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 195 fwKHFLTLKMNISVLVLPLFIFTFLY-------VQMRK------TLRFREQRYSLFKLVFAIMVVFLLMWAPYNI 256
Cdd:cd15400 157 --SSSYTIAVVVIHFIVPITVVSFCYlriwvlvIQVRRkvksesKPRLKPSDFRNFLTMFVVFVIFAICWAPLNL 229
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
46-310 2.78e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 54.34  E-value: 2.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIG---VLDNLLVVLILVKYKGLKRVENIYLLNLAVSNlcFLLTL---PFWAHAG-------GDPMCKiligLY-F 111
Cdd:cd15336   5 SVILIIGitgMLGNALVIYAFCRSKKLRTPANYFIINLAVSD--FLMSLtqsPIFFVNSlhkrwifGEKGCE----LYaF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VG-LYSETFFNCLLT--VQRYLVFLHKGNFF--SARRRVpCGIItsVLAWVTAILATLPEFV---VYKPqmEDQKYKCAF 183
Cdd:cd15336  79 CGaLFGITSMITLLAisLDRYLVITKPLASIrwVSKKRA-MIII--LLVWLYSLAWSLPPLFgwsAYVP--EGLLTSCTW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 SRTPFLPADETFwkhflTLKMNISVLVLPLFIFTFLYV------------------QMRKTLRFREQR----YSLFKLVF 241
Cdd:cd15336 154 DYMTFTPSVRAY-----TMLLFCFVFFIPLGIIIYCYLfiflairstgrevqklgsQDRKEKAKQYQRmkneWKMAKIAF 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 242 AIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYAFldgTFSKY 310
Cdd:cd15336 229 VVILLFVLSWSPYACVALIAWAGYAHLLTPYMKS--------VPAVIAKASAIYNPIIYAI---THPKY 286
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
48-224 4.79e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 54.00  E-value: 4.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-FLLTLPF----------WAHagGDPMCKILIGLYFVGLYS 116
Cdd:cd15005  10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrSLACFPFvmasvrhgsgWIY--GALSCKVIAFLAVLFCFH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLHKgNFFSARRRVPCGIITSVLAWVTAILATLPE-FVVYKPQMEDQKYKCAFSRTPFLPADETF 195
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHH-RFYAKRMTFWTCLAVICMAWTLSVAMAFPPvFDVGTYTFIREEDQCTFEHRSYKANDTLG 166
                       170       180       190
                ....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVLV-LPLFIFTFLYVQMR 224
Cdd:cd15005 167 FMLVLAVVIAATHLVyLKLLIFLRHHRKMK 196
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
44-311 5.11e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 53.62  E-value: 5.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL--CFLLTLP--FW----AHAGGDPMCKILIGLYFVGLY 115
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLvvAFFQVLPqlVWditdRFRGPDVLCRLVKYLQVVGMF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRY------LVFLHKGnffSARRRVPCgiitsVLAWVTAILATLPEFVVykpqmedqkykcaFSRTPFL 189
Cdd:cd15388  86 ASSYMIVAMTFDRHqaicrpMVTFQKG---RARWNGPV-----CVAWAISLILSLPQVFI-------------FSKVEVA 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLT---LKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLF----------------------------- 237
Cdd:cd15388 145 PGVYECWACFIEpwgLKAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYlksqiivavvkkkqllssrassvaevska 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 238 -----KLVFAIMVVFLLMWAPyniaFFLSTFkehFSLSDCKSSYNLDKSVhITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15388 225 miktvKMTLVIVLVYVLCWAP----FFLVQL---WSVWDPKAPTEGATFT-ILMLLASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
40-307 5.29e-08

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 53.63  E-value: 5.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGL 109
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLliynyamrdrWLF--GDFMCRLVRFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFL 189
Cdd:cd15968  80 FYFNLYGSILFLTCISVHRYLGICHPMRPWHKETR-RAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPAL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHFLTlkmnISVLVLPLFIFTFLYVQMRKTL---------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15968 159 FPHYVPYGMALT----VSGFLLPFSIILWCYCLVVRTLcrtlgpaepPAQARRRKSIRTIVTVTLLFALCFLPFHITRTI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15968 235 YLAVRVTPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKF 281
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
41-311 5.74e-08

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 53.23  E-value: 5.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIGLY 110
Cdd:cd15368   3 LPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFqivyhiqrnhWIF--GKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRvPCGIITSVLAWVTAILATLP-EFVVYKPQMEDQKYKCAFS--RTP 187
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKK-RYAVAACIGMWLLVLTALSPlERTDLTYYVKELNITTCFDvlKWT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FLPADETfWKHFLtLKMNISVLVLPLFIFTFLYVQ-----MRKTLRF-REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd15368 160 MLPNIAA-WAAFL-FTLFILLFLIPFIITVYCYVLiilklVQTSERYgREQKRRAIYLALIVLLVFITCFAPNNFILLAH 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 262 TFKEHFslsdckssynLDKSV-HITKLIATTHC---CINPLLYAFLDGTFSKYL 311
Cdd:cd15368 238 MVSRLF----------YGKSLyHAYKLTLSLSClnsCLDPFIYYFASKEFRKKL 281
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-222 6.56e-08

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 53.16  E-value: 6.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LP-----------FWAHAggdpMCKILIGLYFVGL 114
Cdd:cd15208   9 LVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPatllvdvtetwFFGQV----LCKIIPYLQTVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItsvLAWVTAILATLPEFVVykpqMEDQKYKCAFSRTPFLPA-DE 193
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSIL---IIWIVSLLIMIPQAIV----MECSRVVPLANKTILLTVcDE 157
                       170       180       190
                ....*....|....*....|....*....|...
gi 68215224 194 TFWKHFLTLKMNISVLV----LPLFIFTFLYVQ 222
Cdd:cd15208 158 RWSDSIYQKVYHICFFLvtylLPLCLMILAYFQ 190
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
39-311 7.65e-08

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 52.83  E-value: 7.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIG 108
Cdd:cd14991   1 SILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFridyylrgehWIF--GEAWCRVNLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 109 LYFVGLYSETFFNCLLTVQRYLVFL---HKGNFFSARR--RVPCGIitsvlaWVTAILATLPEFVVYKPQMEDQKYKCAF 183
Cdd:cd14991  79 MLSVNRSASIAFLTAVALDRYFKVVhphHRVNRMSVKAaaGVAGLL------WALVLLLTLPLLLSTLLTVNSNKSSCHS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 SRTPFLPADETFWKHFLTLKMnisvLVLPLFIFTFLYVQMRKTLRFREQR------YSLFKLVFAIMVVFLLMWAPYNIA 257
Cdd:cd14991 153 FSSYTKPSLSIRWHNALFLLE----FFLPLGLIVFCSVRIACNLRIRQSLgkqarvQRAIRLVFLVVIVFVLCFLPSIIA 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 258 FFLSTFkeHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14991 229 GLLALV--FKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
40-307 7.71e-08

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 52.66  E-value: 7.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGvldNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF----------LLTLPFWAHagGDPMCKILIGL 109
Cdd:cd17790   5 ITTGILSLVTVTG---NLLVLISFKVNSELKTVNNYFLLSLACADLIIgafsmnlyttYILMGHWAL--GTVACDLWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAilatlpeFVVYKPQMEDQKYKCAfSRTpfL 189
Cdd:cd17790  80 DYVASNASVMNLLIISFDRYFS-ITRPLTYRAKRTPRRAAIMIGLAWLIS-------FVLWAPAILFWQYLVG-ERT--V 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFWKHF----LTLKMNISVLVLPLFIFTFLYVQM-RKTLRFREQRYSLFklvfAIMVVFLLMWAPYNIAFFLSTFk 264
Cdd:cd17790 149 LAGQCYIQFLsqpiITFGTAIAAFYLPVTIMIILYWRIyRETIKEKKAARTLS----AILLAFILTWTPYNIMVLVSTF- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 68215224 265 ehfsLSDC--KSSYNLDksvhitKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd17790 224 ----CKDCvpKTLWELG------YWLCYVNSTVNPMCYALCNKSF 258
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
40-307 8.85e-08

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 52.52  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGvldNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYF 111
Cdd:cd15301   5 IVAAVLSLVTVGG---NVMVMISFKIDKQLQTISNYFLFSLAVADFAIgVISMPLFTVYTalgywplGYEVCDTWLAIDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILaTLPEFVVYKPQMEDQKYkcafsrtpfLPA 191
Cdd:cd15301  82 LASNASVLNLLIISFDRYFS-VTRPLTYRARRTTKKAAVMIASAWIISLL-LWPPWIYSWPYIEGKRT---------VPA 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWK-----HFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYS--LFKLVFAIMVVFLLMWAPYNIAFFLSTFk 264
Cdd:cd15301 151 GTCYIQfletnPYVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQEskAAKTLSAILLAFIVTWTPYNVLVLIKAF- 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 265 ehFSLSDCKSSYNLDKSVHITKLIATthccINPLLYAFLDGTF 307
Cdd:cd15301 230 --FPCSDTIPTELWDFSYYLCYINST----INPLCYALCNAAF 266
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
48-301 1.25e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 52.19  E-value: 1.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAH-------AGGDPMCKI--LIGLYFvGlYSET 118
Cdd:cd15079  10 LGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYnsfyegwALGPLGCQIyaFLGSLS-G-IGSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKgnfFSARR--RVPCGIITsVLAWVTAILATLPEFVV----YKPqmEDQKYKCAFSrtpFLpaD 192
Cdd:cd15079  88 WTNAAIAYDRYNVIVKP---LNGNPltRGKALLLI-LFIWLYALPWALLPLLFgwgrYVP--EGFLTSCSFD---YL--T 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-----FREQ---------RYS-----------LFKLVFAIMVVF 247
Cdd:cd15079 157 RDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFahekaLREQakkmnvvslRSNadankqsaeirIAKVALTNVFLW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 248 LLMWAPYNIAFFLSTFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYA 301
Cdd:cd15079 237 FIAWTPYAVVALIGAFGNQSLLTPLVSM--------IPALFAKTAACYNPIVYA 282
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
41-311 1.28e-07

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 52.50  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHAGGdpMCKILIGLY 110
Cdd:cd14996   3 LPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFqaayflkgfyWKYQST--QCRIANFFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFN----CLLTVQRYLVFLHK---------------GNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYK 171
Cdd:cd14996  81 TLVIHVSMCVSililSWIAISRYATLMKHdsatqkqscyekifyGHFLKRFRQPKFARYLCIYIWGVVLCIIIPVVVYYS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 172 PQMEDQ-----------KYKCAFSRTPFLPADETFWKHFLTlkmnisVLVLPLFIFTFLYVQMRKTLRFREQRY--SLFK 238
Cdd:cd14996 161 VREADEdgeslcynrqvELGAKGSQIAGLIATTFFFLFFLV------VLLSYYSFVNHLRRIQKNTCISEKDLIyrSVKR 234
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68215224 239 LVFAIMVVFLLMWAPYNIafFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd14996 235 NILIIQALLVVCFLPYHI--FKPVFYVLHQREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
48-300 1.33e-07

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 51.98  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYSE 117
Cdd:cd15213  10 MIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDiMLSLVCMPFaavtiitgrWIF--GDIFCRISAMLYWFFVLEG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRrvpcGIITSVLAWVTAILATLP--------EFVVYKPQmedqkykCAFSRTPFl 189
Cdd:cd15213  88 VAILLIISVDRYLIIVQRQDKLNPHR----AKILIAVSWVLSFCVSFPplvgwgkyEFPPRAPQ-------CVLGYTES- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRysLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd15213 156 PADRIY-----VVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTR--AFTTILILFIGFSVCWLPYTVYSLLSVFSRYSSS 228
                       250       260       270
                ....*....|....*....|....*....|.
gi 68215224 270 SDCKSSYNLdksvhitkLIATTHCCINPLLY 300
Cdd:cd15213 229 FYVISTCLL--------WLSYLKSAFNPVIY 251
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-307 1.34e-07

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 52.15  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT---LPFWAHAGGDPMCKILIGLYFVGLYSETFfnCL- 123
Cdd:cd15133  10 IFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgmpLELYELWQNYPFLLGSGGCYFKTFLFETV--CLa 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 124 -------LTVQRYLVFLH--KGNFFSARRRVPcGIITSVlaWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLP---- 190
Cdd:cd15133  88 silnvtaLSVERYIAVVHplAARTCSTRPRVT-RVLGCV--WGVSMLCALPNTSLHGIKFLGSGVPASAQCTVRKPqaiy 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ---ADETFWKHFLTLKMNISVLVL----------PLFIFTFLYVQMRKTLRFREQ---RYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd15133 165 nmiPQHTGHLFFVLPMAVISVLYLlmalrlarerGLDATGAGSKIGTRTGQLLQHprtRAQVTKMLFILVVVFAICWAPF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 255 NIAFFLSTFKEHFSlSDCKSSYNLdksVH-ITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15133 245 HIDRLMWSFISDWT-DNLHEVFQY---VHiISGVFFYLSSAVNPILYNLMSTRF 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
50-309 1.52e-07

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 52.03  E-value: 1.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15393  12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFQFQAAllqrwvlPRFMCPFCPFVQVLSVNVSVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVFLHKGNFFSARRRVPcgiITSVLAWVTAILATLPEFVVYKpqMEDQKYKCAFSRTPF-LP--ADETFWKH 198
Cdd:cd15393  92 TVIAVDRYRAVIHPLKARCSKKSAK---IIILIIWILALLVALPVALALR--VEELTDKTNNGVKPFcLPvgPSDDWWKI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLTLKMNISVLVlPLFIFTFLYVQMRKTLRFREQ---------------RYSLFKLVFAIMVVFLLMWAPYNIAFFLSTF 263
Cdd:cd15393 167 YNLYLVCVQYFV-PLVIICYAYTRIAVKIWGTKApgnaqdvrddeilknKKKVIKMLIIVVALFALCWLPLQTYNLLNEI 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 264 KEhfslsdckssyNLDKSVHI------TKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15393 246 KP-----------EINKYKYIniiwfcSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
40-311 1.97e-07

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 51.69  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG--------GDPMCKILIGLYF 111
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHfsgndwlfGEAMCRVVTAAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPeFVVYKPQMEDQKYKCAFSRTpFLPA 191
Cdd:cd15369  82 CNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAI-WLLSIAGVVP-LLLSEQTIQIPDLGITTCHD-VLNE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DETFWKHFLTLKMNISVL-VLPLFIFTFLYVQMRKTLRF------REQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFK 264
Cdd:cd15369 159 QLLMGYYVYYFSIFSCLFfFVPLIITTVCYVSIIRCLSSssdvanSSKKTRALFMAVAVFCVFVICFGPTNVLLLAHYVR 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 265 EHFSlSDCKSSYnldKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15369 239 FAYT-STNDASY---FAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
39-311 2.52e-07

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 51.21  E-value: 2.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHagGDPMCKILIG 108
Cdd:cd15201   1 YVLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFrtdyylrgkhWKF--GDIPCRIVLF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 109 LYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLpeFVVYKP---QMEDQKYKCAFSR 185
Cdd:cd15201  79 MLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINS-ISVRKAAIIACGLWLLTIAMTV--YLLTKKhlfPRGNATQCESFNI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 TPFLPADETfWKHFltlkMNISVLVLPLFIFTFLYVQMRKTLRFRE-QRYSLFK----LVFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15201 156 CTGTDSSSN-WHEA----MFLLEFFLPLAIILYCSVRIIWQLRGRQlDRHAKIKravqFIMVVAIVFIICFLPSNVTRIA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15201 231 IWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
48-307 4.29e-07

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 50.53  E-value: 4.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF--WAHAGGDPM------CKILIGLYFVGLYSETF 119
Cdd:cd15167  10 IFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVkiAVDLGIAPWklkifhCQVTACLIYINMYLSII 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVV-YKPQMEDQKYKCAFSRTPFlpadETFWkH 198
Cdd:cd15167  90 FLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVV-WTLVLFIMVPNMAIpIKTIEEKPGVGCADFKTEF----GRHW-H 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLT------LKMNISVLVLplfIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVV---FLLMWAPYNIAFFLSTFKEHFSL 269
Cdd:cd15167 164 VLTnficmaIFLNFSAIIL---ISNFLVIRKLYRNKDSEEYRNARQALVNILLVtagYVICFVPYHIVRIPYTLSQSEVI 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 270 SDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15167 241 TDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAF 278
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 4.95e-07

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 50.58  E-value: 4.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGlKRVENIYLLNLAVSNLCFLLTLPFW----AHAGGDPM----CKILIGLYF 111
Cdd:cd15150   2 IFPLLYTVLFIVGLTMNGLAMRVFFQIPS-KSNFIIFLKNTVISDLLMILTFPFKilsdAKLGSWPLrgfvCQVTSVIFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIItSVLAWVTAILATLPEFVVY-KPQMEDQKYKCAFSRTPF-L 189
Cdd:cd15150  81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKIL-STVIWASMFALSLPNMILTnRQPTPKNVKKCSLLKSEFgL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADET--------FWKHFLTlkmnisVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKL-VFAIMVVFLLMWAPYNIAFFL 260
Cdd:cd15150 160 VWHEIvnyicqviFWVNFLI------VIVCYTLITKELYKSYKRTRGVGKVSRKKVNVkVFIIIAVFFICFVPFHFARIP 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 261 STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15150 234 YTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
46-300 6.82e-07

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 50.02  E-value: 6.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPF--------WAHAGGDPMCKILIGLYFVGLYS 116
Cdd:cd15134   8 GIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFelytiwqqYPWVFGEVFCKLRAFLSEMSSYA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETFFNCLLTVQRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLP-------EFVVYKPQMED---QKYKCAFS 184
Cdd:cd15134  88 SVLTITAFSVERYLAICHplRSHTMSKLSRA---IRIIIAIWIIAFVCALPfaiqtriVYLEYPPTSGEaleESAFCAML 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPFlpadetFWKHFLTLKMNIsVLVLPLFIFTFLYVQMRKTLRFRE-----------------QRYSLFKLVFAIMVVF 247
Cdd:cd15134 165 NEIP------PITPVFQLSTFL-FFIIPMIAIIVLYVLIGLQLRRSTllrrgqrsvsggrrssqSRRTVLRMLVAVVVAF 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 248 LLMWAPYNIAFFLSTFkeHFSLSDCKSSYNlDKSVHITKLIATTHCCINPLLY 300
Cdd:cd15134 238 FICWAPFHAQRLLTVY--AKNMTPPYLFIN-RILFYISGVLYYVSSTVNPILY 287
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
40-307 7.25e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 49.96  E-value: 7.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAH---AG----GDPMCKILIGLYf 111
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVaLLVMPLAIIyelSGywpfGEILCDVWISFD- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFN-CLLTVQRYLVFLHKgnFFSARRRVPCGIITSVL-AWVTAILATLPEFVVYKpQMEDQKYKCAFSrtpfl 189
Cdd:cd15329  81 VLLCTASILNlCAISVDRYLVITRP--LTYAVKRTPKRMALMIAiVWLLSALISIPPLFGWK-NKVNDPGVCQVS----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 padetfwKHFL-TLKMNISVLVLPLFIFTFLYVQMRKtLRFREQRYSlfKLVFAIMVVFLLMWAPYniaFFLSTFKEHFS 268
Cdd:cd15329 153 -------QDFGyQIYATFGAFYIPLIVMLVLYYKIYR-AAKSERKAI--KTLGIIMGAFTLCWLPF---FILALLRPFLK 219
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 68215224 269 LSDCksSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15329 220 PIKC--SCIPLWLSRLFLWLGYANSFLNPIIYAKFNREF 256
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 7.61e-07

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 49.95  E-value: 7.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAH-------AGGDPMCKILIGLYF 111
Cdd:cd15125   2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASryfyeewMFGTVGCKLIPVIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSArRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSR-TPFLP 190
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNPMDIQTS-SAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTAcIPYPQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLKMNISVLVlPLFIFTFLYVQMRKTL----------------RFREQRYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd15125 161 TDEMHPKIHSVLIFLVYFLI-PLAIISIYYYHIAKTLiksahnipgeysehskRQMETRKRLAKIVLVFVGLFAFCWFPN 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 255 NIAFFLSTfkehFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15125 240 HVLYMYRS----FNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
49-307 9.41e-07

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 49.79  E-value: 9.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPF----------WAHAGGdpMCKILIGLYFVGLYSET 118
Cdd:cd15199  11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFkayfylngnrWSLGGG--TCKALLFMLSLSRGVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLH---KGNFFSARRrvpcGIITSVLAWVTAILATLPEFVVYKPQmedqkykcAFSRTP-FLPADET 194
Cdd:cd15199  89 AFLTAVALDRYFRVVHprgKKNSLSLQA----APYISFLVWLLLVGLTIPTLLASQPK--------NFTECNsFSPKDDE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWKHFLTLKMNISVLVLPLFIFTFLYV----QMRKTLRFREQRYSLFK---LVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15199 157 DFSDTWQEAVFFLQFLLPFGLIVFCTVriirRLKKRLRDVGKQPKLQRamaLVTSVVVVFGFCFLPCFLARVLMLIFQNK 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 268 SLsdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15199 237 ES--CNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTF 274
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
40-309 1.14e-06

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 49.24  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGvldNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWA-------HAGGDPMCKILIGLYF 111
Cdd:cd15049   5 IATGSLSLVTVGG---NILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTvylvmgyWPLGPLLCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHKGNFFSAR--RRVPCGI----ITSVLAWVTAILAtLPEFVVYKPQMEDQKYkcafsr 185
Cdd:cd15049  82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRtpKRAILMIalawVISFVLWAPAILG-WQYFVGERTVPDGQCY------ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 TPFLpADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRfREQRysLFKLVFAIMVVFLLMWAPYNIAFFLSTFke 265
Cdd:cd15049 155 IQFL-DDPAI-----TFGTAIAAFYLPVLVMTILYWRIYRETA-RERK--AARTLSAILLAFIITWTPYNILVLVSTF-- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 266 hfslsdCKSSYNlDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15049 224 ------CAKCIP-DTLWSFGYWLCYINSTINPFCYALCNKTFRK 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
40-271 1.51e-06

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 48.88  E-value: 1.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGL 109
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFslvnelmgyWYF--GSVWCEIWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSAR--RRVPCGIITsvlAWVTAILATLPEFVVYKPQM--EDQKYKCAFSR 185
Cdd:cd15059  80 DVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRtpRRAKAMIAA---VWIISAVISLPPLFGWKDEQpwHGAEPQCELSD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 186 TP---FLPADETFWkhfltlkmnisvlvLPLFIFTFLYVQMRKTLRFREQRyslFKLVFAI-MVVFLLMWAPYNIAFFLS 261
Cdd:cd15059 157 DPgyvLFSSIGSFY--------------IPLLIMIIVYARIYRAAKRKERR---FTLVLGVvMGAFVLCWLPFFFTYPLV 219
                       250
                ....*....|
gi 68215224 262 TFKEHFSLSD 271
Cdd:cd15059 220 VVCKTCGVPE 229
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
44-307 1.81e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 48.71  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYFVGLY 115
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLcLFCMPFTLIPNllkdfifGSAVCKTATYFMGISVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLH--KGNFFSARRRVpCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTpFLPAD- 192
Cdd:cd15978  86 VSTFNLVAISLERYSAICKplKSRVWQTKSHA-LKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRL-LWPNDv 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 -ETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFkehfslsD 271
Cdd:cd15978 164 tQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRAF-------D 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 272 CKSSYNLDKSVHIT--KLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15978 237 TRSADRLLSGAPISfiHLLSYTSACVNPIIYCFMNKRF 274
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
40-312 2.08e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 48.58  E-value: 2.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL--CFLLT-LPFWAHAGGdpmcKILIGLYFVGLYS 116
Cdd:cd15086   2 VVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLlvCVLGTpFSFAASTQG----RWLIGEHGCRWYG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 etFFNCL-----------LTVQRYLVFLHKGNFFSARRRVPCGIITsvLAWVTAILATLPEFV---VYKPqmEDQKYKCA 182
Cdd:cd15086  78 --FANSLfgivslislavLSYERYCTLLRPTEADVSDYRKAWLGVG--GSWLYSLLWTLPPLLgwsSYGP--EGPGTTCS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 183 FSRTPFLPADETFwkhflTLKMNISVLVLPLFIFTFLYVQM-----------RKTLRFREQRYSLfkLVFAIMVVFLLMW 251
Cdd:cd15086 152 VQWTSRSANSISY-----IICLFIFCLLLPFLVMVYCYGRLlyaikqvgkinKSTARKREQHVLL--MVVTMVICYLLCW 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 252 APYNIAFFLSTFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYAFLDGTFskYLC 312
Cdd:cd15086 225 LPYGVMALLATFGKPGLVTPVASI--------VPSILAKSSTVVNPIIYVFMNKQF--YRC 275
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-265 2.63e-06

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 48.30  E-value: 2.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-----LLTLPFWAHAG---GDPMCKIL----IGLYFVG 113
Cdd:cd16004   8 SLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMaafntAFNFVYASHNDwyfGLEFCRFQnffpITAMFVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETffncLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRtpflpADE 193
Cdd:cd16004  88 IYSMT----AIAADRYMAIIHP---FKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAW-----PGD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWKHFLTLKMNISVLV--LPLFIFTFLYVQMRKTL------------RFREQRYSLFKLVFAIMVV---FLLMWAPYNI 256
Cdd:cd16004 156 SGGKHQLTYHLAVIVLIylLPLAVMFVTYSIIGITLwrsavpghqahgAYHRQLQAKKKFVKTMVVVvvtFAICWLPYHL 235

                ....*....
gi 68215224 257 AFFLSTFKE 265
Cdd:cd16004 236 YFILGSFNE 244
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
49-309 2.85e-06

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 48.13  E-value: 2.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIGVLDNLLVVLILVKYKGLKRVE-NIYLLNLAVSNLCF-LLTLPF---------WAhaGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15383  11 FVLSACSNLAVLWSATRNRRRKLSHvRILILHLAAADLLVtFVVMPLdaawnvtvqWY--AGDLACRLLMFLKLFAMYSS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRvpcGIITSVLAWVTAILATLPEFVVYKpqmedqkykcAFSRTP---------- 187
Cdd:cd15383  89 AFVTVVISLDRHAAILNPLAIGSARRR---NRIMLCAAWGLSALLALPQLFLFH----------TVTATPpvnftqcath 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 -FLPAD--ETFWK--HFLTLkmnisvLVLPLFIFTFLYV--------QMRKTL--------------RFREQRYSLFKLV 240
Cdd:cd15383 156 gSFPAHwqETLYNmfTFFCL------FLLPLLIMIFCYTrilleisrRMKEKKdsaknevalrsssdNIPKARMRTLKMT 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 241 FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNldksvHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15383 230 IVIVSSFIVCWTPYYLLGLWYWFSPEMLEQTVPESLS-----HILFLFGLLNACLDPLIYGLFTISFRR 293
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
40-311 3.02e-06

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 48.24  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGlKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDP--------MCKILIGLYF 111
Cdd:cd15151   2 VFPVLYTVLFLVGLILNSVAAWIFFHIPS-TSTFIVYLKNTLVADLIMTLMLPFKILSDSGLgpwqlrafVCRFSAVVFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLHK-GNFFSarRRVPCGIITSVLAWVTAILATLPEFVVY-KPQMEDQKYKCAFSRTPF- 188
Cdd:cd15151  81 ITMYISIILLGLISFDRYLKIVRPfGKSWV--QRVRFAKILSGAVWLVMFLLSVPNMILSnKPATPISVKKCASLKSPLg 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADET--------FWKHFLTLkmnisvLVLPLFIFTFLYVQMRKTLRFREQRYSLFKL-VFAIMVVFLLMWAPYNIAFF 259
Cdd:cd15151 159 LKWHEVvnyicqfiFWGVFALM------VLFYTIISKKVYESYKKSRSKDNKASKKTKAkVFIIVAVFFVCFAPFHFVRV 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 260 LSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15151 233 PYTLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
40-168 3.07e-06

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 47.95  E-value: 3.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVL-ILVKYKGLKRVeNIYLLNLAVSNLCFLLTLP----------FWAHagGDPMCKILIG 108
Cdd:cd15379   2 LLPLVYSVVFLLGLPLNAVVIGqIWATRQALSRT-TIYMLNLATADLLYVCSLPlliynytqkdYWPF--GDFTCRLVRF 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 109 LYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFV 168
Cdd:cd15379  79 QFYTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVCGAVWLVVIAQCLPTFV 138
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
43-307 4.38e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 47.87  E-value: 4.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL--TLP--FWA----HAGGDPMCKILIGLYFVGL 114
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLPqlIWEityrFQGPDLLCRAVKYLQVLSM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSvlAWVTAILATLPEFVVYKPQMEDQK---YKC-AFSRTPFLP 190
Cdd:cd15386  85 FASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGA--TWLLSCILSLPQVFIFSLREVDQGsgvLDCwADFGFPWGA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWkhfltlkMNISVLVLPLFIFTFLY----VQMRKTLRFREQ----------------RYS-----------LFKL 239
Cdd:cd15386 163 KAYITW-------TTLSIFVLPVAILIVCYslicYEICKNLKGKTQtsrsegggwrtqgmpsRVSsvrtisrakirTVKM 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 240 VFAIMVVFLLMWAPYNIAFFLSTFKEhfSLSDCKSSynlDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15386 236 TFVIVLAYIACWAPFFSVQMWSVWDE--NAPDEDSS---DFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
50-302 4.84e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 47.29  E-value: 4.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL--------CFLLTLPFwAHAGGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd14972  10 VFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLlagiafvfTFLSVLLV-SLTPSPATWLLRKGSLVLSLLASAYSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLvFLHKGNFFSARRRVPCGIITSVLAWVTAI-LATLPEFVvykpqmedqkYKCAFSRTPF-LPADETFWKHF 199
Cdd:cd14972  89 LAIAVDRYI-SIVHGLTYVNNVTNKRVKVLIALVWVWSVlLALLPVLG----------WNCVLCDQEScSPLGPGLPKSY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 200 LTLkmnISVLVL-PLFIFTFLYV----------------QMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLST 262
Cdd:cd14972 158 LVL---ILVFFFiALVIIVFLYVrifwclwrhanaiaarQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 263 FkehfslsdCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd14972 235 L--------CPSVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
44-311 5.23e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 47.50  E-value: 5.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYFVGLY 115
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLIPNlmgtfifGEVICKAVAYLMGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLhkgNFFSAR----RRVPCGIITSvlAWVTAILATLPEFVVYKPQMEDQKYKCAFS----RTP 187
Cdd:cd15979  86 VSTFSLVAIAIERYSAIC---NPLQSRvwqtRSHAYRVIAA--TWLLSGLIMIPYPVYSVTVPVPVGDRPRGHqcrhAWP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FLPADETFWKHFLTLkmnisVLVLPLFIFTFLY-VQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKE- 265
Cdd:cd15979 161 SAQVRQAWYVLLLLI-----LFFIPGVVMIVAYgLISRELYRGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWRAFDPl 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 68215224 266 --HFSLSDCKSSYnldksVHitkLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15979 236 saHRALSGAPISF-----IH---LLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-310 5.38e-06

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 47.52  E-value: 5.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-------------LPFWAHAGGDPMCKIL--IGLYFV 112
Cdd:cd15128  10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIdlpinvykllamdWPFGDQPFGQFLCKLVpfIQKASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLyseTFFN-CLLTVQRYLVFLhkgnffSARRRVPCGI-----ITSVLAWVTAILATLPEFVVYkpQMEDQKYKCAFSRT 186
Cdd:cd15128  90 GI---TVLNlCALSVDRYRAVA------SWSRIQGIGIpmwtaVEIVMIWMLSAVLAVPEAIGF--DMVRFNYKGVTLRT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFLPADETFWKHFLTLK---MNISVLVLPLFIFTFLYVQMRKTLRFRE-------------QRYSLFKLVFAIMVVFLLM 250
Cdd:cd15128 159 CLLRPETSFMKFYIDVKdwwLFGFYFCLPLVCTAIFYTLMTCEMLRKRngmlrialnehlkQRREVAKTVFCLVVIFALC 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 251 WAPYNIAFFLS-TFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd15128 239 WLPLHLSRILKlTVYDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNC 299
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
46-311 5.49e-06

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 47.22  E-value: 5.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAH-------AGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15123   8 AVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATryiadtwLFGRIGCKLLSFIQLTSVGVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLhKGNFFSARRRVPCGIITSVLAWVTAILATLPEFV---VYkpQMEDQKYKCAFSRTPFLPADET 194
Cdd:cd15123  88 VFTLTVLSADRYRAIV-KPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVfsdLY--SFRDPEKNTTFEACAPYPVSEK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTL----------------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAF 258
Cdd:cd15123 165 ILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLykstfnmpaeehsharKQIESRKRVAKTVLVLVALFAFCWLPNHILY 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 259 FLSTFKEHFSLSdcKSSYNLDKSVhITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15123 245 LYRSFTYHTSVD--SSAFHLIATI-FSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
43-277 6.03e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 46.86  E-value: 6.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFV 112
Cdd:cd15322   5 ILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFslanevmgyWYF--GKVWCEIYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIITsvlAWVTAILATLPEFVVYKPQMEDQKykcafsrTPFLP 190
Cdd:cd15322  83 FCTSSIVHLCAISLDRYWSITQaiEYNLKRTPRRIKCIIFI---VWVISAVISFPPLITIEKKSGQPE-------GPICK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWkhfLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRyslFKLVFAIMV-VFLLMWAPYNIAFFLST------- 262
Cdd:cd15322 153 INDEKW---YIISSCIGSFFAPCLIMVLVYIRIYQIAKNREKR---FTFVLAVVIgVFVICWFPFFFTYTLTAvcdcsvp 226
                       250
                ....*....|....*...
gi 68215224 263 ---FKEHFSLSDCKSSYN 277
Cdd:cd15322 227 etlFKFFFWFGYCNSSLN 244
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
46-301 6.17e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 47.10  E-value: 6.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAH-------AGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15062   8 GAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATlevlgywAFGRIFCDVWAAVDVLCCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFS--ARRRvpcGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadetf 195
Cdd:cd15062  88 IMSLCVISVDRYIGVRYPLNYPTivTARR---ATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVNEEP-------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 wkhFLTLKMNISVLVLPLFIFTFLYVQM-RKTLRFREQRYSLFKLvfAIMV-VFLLMWAPYNIAFFLSTFkehfsLSDCK 273
Cdd:cd15062 157 ---GYVLFSSLGSFYLPLAIILVMYCRVyVVAFKFSREKKAAKTL--GIVVgAFVLCWFPFFVVLPLGSL-----FSTLK 226
                       250       260
                ....*....|....*....|....*...
gi 68215224 274 SSYNLDKSVHitkLIATTHCCINPLLYA 301
Cdd:cd15062 227 PPEPVFKVVF---WLGYFNSCLNPIIYP 251
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
44-307 6.98e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 46.90  E-value: 6.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYFVGLY 115
Cdd:cd15330   6 FLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVsVLVLPMAALYQvlnkwtlGQVTCDLFIALDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSvLAWVTAILATLPEFVVYK-PQMEDQKYKCAFSRTPFLPADET 194
Cdd:cd15330  86 SSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLIS-LTWLIGFSISIPPMLGWRtPEDRSDPDACTISKDPGYTIYST 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FwkhfltlkmniSVLVLPLFIFTFLYVQMRKTLRfREQRysLFKLVFAIMVVFLLMWAPyniaFFLSTFKEHFSLSDCKS 274
Cdd:cd15330 165 F-----------GAFYIPLILMLVLYGRIFKAAA-RERK--TVKTLGIIMGTFILCWLP----FFIVALVLPFCESTCHM 226
                       250       260       270
                ....*....|....*....|....*....|...
gi 68215224 275 SYNLDKsvhITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15330 227 PELLGA---IINWLGYSNSLLNPIIYAYFNKDF 256
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
46-253 7.10e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.86  E-value: 7.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVK-YKGLKRvENIYLL--NLAVSNLC-FLLTLP--FWAHA------GGDPMCKILIGLY-FV 112
Cdd:cd14981   8 ALMFVFGVLGNLLALIVLARsSKSHKW-SVFYRLvaGLAITDLLgILLTSPvvLAVYAsnfewdGGQPLCDYFGFMMsFF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLySETFFNCLLTVQRYLVFLHKgNFFSARRRVPCGIITSVLAWVTAIL-ATLP-----EFVVYKP-----------QME 175
Cdd:cd14981  87 GL-SSLLIVCAMAVERFLAITHP-FFYNSHVKKRRARLMLGAVWAFALLiASLPllglgSYVLQYPgtwcfldfyskNTG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 176 DQKYKCAFSRTPFLPAdetfwkhFLTLKMNISVlvlplfIFTFLYV---QMRKTLRFREQRYS----LFKLVF--AIMVV 246
Cdd:cd14981 165 DAAYAYLYSILGLLIL-------LVTLLCNLLV------IITLLRMrrrKKRHRRSRRSARRQkrneIQMVVLllAITVV 231

                ....*..
gi 68215224 247 FLLMWAP 253
Cdd:cd14981 232 FSVCWLP 238
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-309 9.10e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 46.58  E-value: 9.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYfVGLYSETF 119
Cdd:cd15061  11 IFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVgVLVLPLaiirqllgyWPL--GSHLCDFWISLD-VLLCTASI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FN-CLLTVQRYLVFLHKGNFFSAR-RRVPCGIITSVlaWVTAILATLPEFVVYKPQMEDQKYKCAFSRTP---FLPADET 194
Cdd:cd15061  88 LNlCCISLDRYFAITYPLKYRTKRsRRLAITMILAV--WVISLLITSPPLVGPSWHGRRGLGSCYYTYDKgyrIYSSMGS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWkhfltlkmnisvlvLPLFIFTFLYVQMRKTLRfREQRYSlfKLVFAIMVVFLLMWAPyniaFFLSTFKEHFslSDCKS 274
Cdd:cd15061 166 FF--------------LPLLLMLFVYLRIFRVIA-KERKTA--KTLAIVVGCFIVCWLP----FFIMYLIEPF--CDCQF 222
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 275 SYNLDKSVhitKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15061 223 SEALSTAF---TWLGYFNSVINPFIYAFYNKDFRR 254
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
47-300 1.00e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 46.44  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVI-GVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAH-------AGGDPMCKILIGLYFVGLYSE 117
Cdd:cd15327   8 AIFILmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFSATlevlgfwAFGRVFCDIWAAVDVLCCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWK 197
Cdd:cd15327  88 ILSLCVISVDRYVGVKHSLKYPTIMTERKAGVIL-VLLWVSSMVISIGPLLGWKEPPPPDESICSITEEPGYALFSSLFS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 HFLTLkMNISVLVLPLFIFTFLYVQMRKTLRfreqryslfklVFAIMV-VFLLMWAPYniaFFLSTFKEHFSlsdckssy 276
Cdd:cd15327 167 FYLPL-MVILVMYFRVYVVALKFSREKKAAK-----------TLAIVVgVFILCWFPF---FFVLPLGSFFP-------- 223
                       250       260
                ....*....|....*....|....*..
gi 68215224 277 NLDKSVHITKLI---ATTHCCINPLLY 300
Cdd:cd15327 224 ALKPSEMVFKVIfwlGYFNSCVNPIIY 250
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
50-309 1.02e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 46.42  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWA-------HAGGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15325  12 LFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAifeilgyWAFGRVFCNIWAAVDVLCCTASIMSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVF---LHKGNFFSARRrvpcGIITSVLAWVTAILATL-PEFVVYKPQMEDQKYkCAFSRTP---FLPADET 194
Cdd:cd15325  92 CIISIDRYIGVsypLRYPSIMTERR----GLLALLCVWVLSLVISIgPLFGWKEPAPEDETI-CQITEEPgyaLFSALGS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 195 FWkhfltlkmnisvlvLPLFIFTFLYVQMR-KTLRF-REQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSdc 272
Cdd:cd15325 167 FY--------------LPLAIILVMYCRVYvVALKFsREKKAA--KTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPS-- 228
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 68215224 273 kssynlDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15325 229 ------DTVFKITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
44-309 1.17e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 46.27  E-value: 1.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFwaHAGGDPMCKILIGLYFVGLY------- 115
Cdd:cd15060   6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVaIFVLPL--NVAYFLLGKWLFGIHLCQMWltcdilc 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 -SETFFN-CLLTVQRYLVfLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYK--PQMEDQKYKCAFSRtpflpa 191
Cdd:cd15060  84 cTASILNlCAIALDRYWA-IHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNdwPENFTETTPCTLTE------ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 detfwKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRfREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFkehfslsd 271
Cdd:cd15060 157 -----EKGYVIYSSSGSFFIPLLIMTIVYVKIFIATS-KERRAA--RTLGIIMGVFVVCWLPFFLMYVILPF-------- 220
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 68215224 272 CKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15060 221 CETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
44-311 1.55e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 45.91  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC-FLLTLPF----------WAHagGDPMCkILIGLYFV 112
Cdd:cd15212   6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFafltlfsrpgWLF--GDRLC-LANGFFNA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GL-YSETFFNCLLTVQRYLVFLHKGNFFSARRRvpcGIITSVLAWVTAILATLPEFVVYKPQMEDQK---YKCAFsrtpF 188
Cdd:cd15212  83 CFgIVSTLTMTLISFDRYYAIVRQPQGKIGRRR---ALQLLAAAWLTALGFSLPWYLLASAPEYYEKlgfYHCLY----V 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQR-------------YSLFKL--VFAIMVVFLLM-WA 252
Cdd:cd15212 156 LHSGPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRvrpvttyahllrfYSEMRTatTVLIMIVFIICcWG 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 253 PYNIAFFLSTfkehfsLSDCKSSYNLDKSVhitKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15212 236 PYCLLGLVAA------AGGYQFPPLMDTVA---IWMAWANGAINPLIYAIRNPNISMLL 285
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
53-309 1.59e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 45.80  E-value: 1.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  53 VLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF----------WAHagGDPMCKILIGLYFVGLYSETFFN 121
Cdd:cd15053  15 VFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVaILVMPFavyvevnggkWYL--GPILCDIYIAMDVMCSTASIFNL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVFLH--KGNFFSARRRVpCGIITSVlaWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLpadetfwkhf 199
Cdd:cd15053  93 CAISIDRYIAVTQpiKYARQKNSKRV-LLTIAIV--WVVSAAIACPLLFGLNNVPYRDPEECRFYNPDFI---------- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 200 ltLKMNISVLVLPLFIFTFLYVQMRKTLRfREQRYSlfKLVFAIMVVFLLMWAPYniafflstFKEHFSLSDCKSSYNLD 279
Cdd:cd15053 160 --IYSSISSFYIPCIVMLLLYYRIFRALR-REKKAT--KTLAIVLGVFLFCWLPF--------FTLNILNAICPKLQNQS 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 280 KSVHITKLIATT-----HCCINPLLYAFLDGTFSK 309
Cdd:cd15053 227 CHVGPALFSLTTwlgyvNSFLNPIIYTIFNIEFRK 261
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
40-309 1.65e-05

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 45.97  E-value: 1.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFvIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGL 109
Cdd:cd15399   3 LILAYCSIIL-LGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFtlvytlldeWKF--GAVLCHLVPYA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRY-LVFLHKGNFFSARRrvpCGIITSVLAWVTAILAT-LPEFVVYKPQMEDQKYKCAFSRTP 187
Cdd:cd15399  80 QALAVHVSTVTLTVIALDRHrCIVYHLESKISKKI---SFLIIGLTWAASALLASpLAIFREYSVIEISPDFKIQACSEK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FlPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR-----------FREQRYSLFKLVFAIMVVFLLMWAPYNI 256
Cdd:cd15399 157 W-PNGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKnhvspgggndhYHQRRRKTTKMLVCVVVVFAVSWLPFHA 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 257 AFFLSTF-KEHFSLSDCKSSYNLdksVHItklIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15399 236 FQLASDIdSKVLDLKEYKLIYTI---FHV---IAMCSTFANPLLYGWMNNNYRT 283
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
47-307 2.01e-05

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 45.55  E-value: 2.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLP----FWAHAGGDPMCKIL-IGLYFVGLYSETFFN 121
Cdd:cd15163   9 LIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPtrivMYYSAGNCLTCSFVhIFSYFVNMYCSILFL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 CLLTVQRYLVFLHKGNffSARRRVP-CGIITSVLAWVTAILAT---LPEFVVYKpqmedqkyKCAFSRTPFLPADETFwk 197
Cdd:cd15163  89 TCICVDRYLAIVQVEA--SRRWRNPnYAKGICVFIWLFAIVVTfsiLTTAIKFA--------SCCLSKLFALTVFEFF-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 198 hfltlkmnisvlvLPLFIFTFLYVQMRKTL-------RFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLS 270
Cdd:cd15163 157 -------------LPLLIITFFTIRIMCALsrpglmhQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAVAFNPDIPHH 223
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 68215224 271 DCKSSYnldksvHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15163 224 TSLIVY------HVTVTLSSLNSCMDPIVYCFVTNNF 254
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
48-307 2.77e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 45.00  E-value: 2.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFwahaggdPMCKILIGLYF--------VGLYSET 118
Cdd:cd15052  10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVgLLVMPL-------SILTELFGGVWplplvlclLWVTLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFN-------CLLTVQRYLVF---LHKGNFFSaRRRVpcgIITSVLAWVTAILATLPEFVVYkpqMEDQkyKCAFSRTPF 188
Cdd:cd15052  83 LFCtasimhlCTISLDRYMAIrypLRTRRNKS-RTTV---FLKIAIVWLISIGISSPIPVLG---IIDT--TNVLNNGTC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRfREQRYS-LFKLVFAImvvFLLMWAPYNIAFFLSTFKEHf 267
Cdd:cd15052 154 VLFNPNF-----VIYGSIVAFFIPLLIMVVTYALTIRLLS-NEQKASkVLGIVFAV---FVICWCPFFITNILTGLCEE- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 68215224 268 slSDCKSSYNLDKSVHITKLIATThccINPLLYAFLDGTF 307
Cdd:cd15052 224 --CNCRISPWLLSVFVWLGYVSST---INPIIYTIFNKTF 258
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
40-311 3.70e-05

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 44.78  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGlKRVENIYLLNLAVSNLCFLLTLPF--WAHAGGDP------MCKILIGLYF 111
Cdd:cd15969   2 VFPVLYLIIFIGSILLNGLAVWIFFHIRN-KTSFIFYLKNIVIADLLMTLTFPFkiIQDSGLGPwnfnffLCRYTSVLFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLhKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQ-MEDQKYKCAFSRTPFlp 190
Cdd:cd15969  81 ASMYTSIVFLGLISLDRYLKVV-KPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQpTEDNIHDCSKLKSPL-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 adETFWkHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLF--------KLVFAIMVVFLLMWAPYNIAFFLST 262
Cdd:cd15969 158 --GVKW-HTAVSYINICIFVAVLVILIVCYISISRYIYKSSKQFISSssrtrkhnQSIRVVVAVFFVCFLPYHLCRIPFT 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 263 FKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15969 235 FSQLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
39-257 3.92e-05

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 44.73  E-value: 3.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVEN-IYLLNLAVSNLCFLLTLPF---WAHAGGDPMCKILIGLY---- 110
Cdd:cd14983   1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIkivEALSSAWTLPAVLCPLYnlah 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYL--VFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQM-EDQKYKCAFSRTP 187
Cdd:cd14983  81 FSTLYASTCFLTAISAGRYLgvAFPIK---YQLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGtLDINTPVGNSSTC 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 188 FLPADETFWKHFLTLKMNISVLV--LPLFIFTFLYVQ-----MRKTLRFREQRYSLfKLVFAIMVVFLLMWAPYNIA 257
Cdd:cd14983 158 YENFTPEQLALLAPVRLELSLVLffLPLAITAFCYVRcirilVRSRLHERRKRRAV-RVAVSTLLTFVVCFGPYNIS 233
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
99-309 4.29e-05

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 44.70  E-value: 4.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  99 GDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLaWVTAILATLPEFVVYKPQMEDQK 178
Cdd:cd15922  69 GQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGV-WLLLFVQGLPFFFVLKTSVIDGK 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 179 YKCAFSRTPFLPADETFWKHFLTlkmnISVLVLPLFIFTFLYV-------QMRKT-LRFREQRYSLFKLVFAIMVVFLLM 250
Cdd:cd15922 148 TKCLSIHQSELSLLYFVWNFVLL----ILGFLLPFGVSLTCYAllgasiaKMNSNnARGRAMKAKSLQMIGISLVIFIIC 223
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 68215224 251 WAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15922 224 FVPLHVTRTVGVVVKLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
44-311 4.32e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 44.43  E-value: 4.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL---TLPF---------WAHAGG--DPMCKILIGL 109
Cdd:cd15078   6 LIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLlgvTFTFmscvrgrwvFDVAGCvwDGFSNSLFGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSetffncLLTVQRYLVFLH-KGNFFSARRRVPCGIITSVLAWVTAILATLPEFVvykpqMEDQKYKCAFSRTPF 188
Cdd:cd15078  86 VSIMTLT------VLAYERYIRVVHaKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYT-----LEVHGLGCSFDWKSK 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFWKHFLtlkmnISVLVLPLFIFTFLY---------------VQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAP 253
Cdd:cd15078 155 DPNDTSFVLLFF-----LGCLVVPLGIMAYCYghilyeirmlrsvedLQTFQVIKILKYEKKVAKMCLLMISTFLICWMP 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 254 YNIAFFLSTFKehfslsdcKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15078 230 YAVVSLLVTSG--------YSKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
46-165 4.46e-05

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 44.68  E-value: 4.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWA--HAGGDP------MCKILIGLYFVGLYSE 117
Cdd:cd15148   8 SLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRIlyHVNNNQwtlgplLCKVVGNLFYMNMYIS 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 118 TFFNCLLTVQRYLvflhKGNFFSARRRV---PCGIITSVLAWVTAILATLP 165
Cdd:cd15148  88 IILLGFISLDRYL----KINRSSRRQKFltrKWSIVACGVLWAVALVGFVP 134
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-309 4.59e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 44.55  E-value: 4.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENI---YLLNLAVSNLCFLLT-LP------FWAH---AGGDPMCKil 106
Cdd:cd15130   2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILLLaMPvelynfIWVHhpwAFGDAGCR-- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 107 iGLYFVG---LYSETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIitsVLAWVTAILATLPEFVVYKPQMEDQKYKC 181
Cdd:cd15130  80 -GYYFLRdacTYATALNVASLSVERYLAICHpfKAKTLMSRSRTKKFI---SAIWLASALLAIPMLFTMGLQNESDDGTH 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 182 AFSRTPFLPADETFWKHFLTLKMNISvLVLPLFIFTFLYVQMRKTLrFREQRYSLfKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd15130 156 PGGLVCTPIVDTATLKVVIQVNTFMS-FLFPMLVTSILNTVIANKL-VQALRRGV-LVLRAVVIAFVVCWLPYHVRRLMF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 68215224 262 TFkehfsLSDCKSSYNLDKSVH----ITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15130 233 CY-----ISDEQWTTFLFDFYHyfymLTNALFYVSSAINPILYNLVSANFRQ 279
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
199-316 4.75e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 44.54  E-value: 4.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  199 FLTLKMNISVL--VLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFA--IMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKS 274
Cdd:PHA03234 194 FIAIKIVFCFIwgIFPTMIFSFFYVIFCKALHALTEKKHKKTLFFIriLILSFLCIQIPNIAILICEIAFLYIANNSCFG 273
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 68215224  275 SYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFH 316
Cdd:PHA03234 274 LAQREILQIIIRLMPEIHCFSNPLVYAFTGGDFRLRFTACFQ 315
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
48-307 5.47e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 44.04  E-value: 5.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN--LCFLLTLPFWAHAG------GDPMCKILIGLYFVGLYSETF 119
Cdd:cd15076  10 VFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGfiFCIFSVFPVFVASAqgyfffGRTVCALEAFVGSLAGLVTGW 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHK-GNF-FSARRrvpcGIITSVLAWVTAILATLPEFVVYKPQM-EDQKYKCAfsrTPFLPADETFW 196
Cdd:cd15076  90 SLAFLAFERYIVICKPfGNFrFGSKH----ALGAVVATWIIGIGVSLPPFFGWSRYIpEGLQCSCG---PDWYTVGTKYR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 KHFLTLKMNISVLVLPLFIFTFLYVQMRKTLR--FREQRYS---------LFKLVFAIMVVFLLMWAPYN-IAFFLSTFK 264
Cdd:cd15076 163 SEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRavAAQQQESastqkaereVSRMVVVMVGSFCLCYVPYAaLAMYMVNNR 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 68215224 265 EHfslsdckssyNLD-KSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15076 243 DH----------GLDlRLVTIPAFFSKSSCVYNPIIYCFMNKQF 276
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-307 6.15e-05

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 44.13  E-value: 6.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLL-TLPF---------WAHAGgdPMCKI--LIGLYFVGLY 115
Cdd:cd15977  10 IFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILiAIPInvikliaedWPFGV--HVCKLypFIQKASVGIT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFfnCLLTVQRYLVFLhkgnffSARRRVPCGI-----ITSVLAWVTAILATLPEFVVYkpQMEDQKYKCAFSRTPFLP 190
Cdd:cd15977  88 VLSL--CALSIDRYRAVA------SWSRIRGIGIpvwkaVEVTLIWAVAIIVAVPEAIAF--DMVEIDYRGQTLLVCMLP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETfwKHFLTLKMNISV-------LVLPLFIFTFLYVQM-------RKTLRF-----REQRYSLFKLVFAIMVVFLLMW 251
Cdd:cd15977 158 MEQT--SSFMRFYQDVKDwwlfgfyFCLPLACTGVFYTLMscemlsiKNGMRIalndhMKQRREVAKTVFCLVVIFALCW 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 252 APYNIA-FFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15977 236 LPLHLSrILKKTIYDVKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKF 292
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
47-300 8.22e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 43.73  E-value: 8.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  47 AVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAHAG-------GDPMCKILIGLYFVGLYSET 118
Cdd:cd15326   9 AFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEilgywvfGRIFCDIWAAVDVLCCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGNF--FSARRRVpcgIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPflpadetfw 196
Cdd:cd15326  89 LSLCAISIDRYIGVRHSLQYptIVTRKRA---ILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEITEEP--------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 197 khFLTLKMNISVLVLPLFIFTFLYVQMR-KTLRF-REQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFKEHfslsdcks 274
Cdd:cd15326 157 --FYALFSSLGSFYIPLIVILVMYCRVYiVALKFsREKKAA--KTLGIVVGMFILCWLPFFIALPLGSLFSH-------- 224
                       250       260
                ....*....|....*....|....*....
gi 68215224 275 synLDKSVHITKLI---ATTHCCINPLLY 300
Cdd:cd15326 225 ---LKPPETLFKIIfwlGYFNSCLNPIIY 250
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
41-309 1.03e-04

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 43.35  E-value: 1.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-LPFWAHAG-------GDPMCKILIGLYFV 112
Cdd:cd15124   3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYladewlfGRVGCKLIPFIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 113 GLYSETFFNCLLTVQRYLVFLHKGNFfSARRRVPCGIITSVLAWVTAILATLPE--FVVYKPQMEDQKYKCAFSRTPFLP 190
Cdd:cd15124  83 SVGVSVFTLTALSADRYKAIVRPMDI-QASNALMKICLKAALIWILSMLLAIPEavFSDLHPFYDKSTNKTFVSCAPYPH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKhFLTLKMNISVLVLPLFIFTFLYVQMRKTL----------------RFREQRYSLFKLVFAIMVVFLLMWAPY 254
Cdd:cd15124 162 SNELHPK-IHSMASFLIFYVIPLSIISVYYYFIAKNLirsaynlpvegnvhvrRQIESRKRLAKTVLVFVGLFAFCWLPN 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 255 NIAFFLSTFkeHFSLSDcKSSYNLDKSVhITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15124 241 HIIYLYRSY--HYSEVD-TSMLHFVSSI-CARILAFTNSCVNPFALYLLSKSFRK 291
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
46-309 1.20e-04

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 43.19  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15397   8 SLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDiLVCLVCLPFtvvytlmdyWIF--GEVLCKMTPFIQCMSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFfsaRRRVPCGIITSVLAWVTAILATLPeFVVYKpQMEDQKYKCAFSRTPFLpAD--- 192
Cdd:cd15397  86 VSILSLVLIALERHQLIINPTGW---KPSVSQAYLAVVVIWMLACFISLP-FLAFH-ILTDEPYKNLSHFFAPL-ADkav 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 193 --ETFWKHFLTLKMNISVLV----LPL-FIFT-----FLYVQMRKTLRFREQRYSLFK--------LVFAIMVVFLLMWA 252
Cdd:cd15397 160 ctESWPSEHHKLAYTTWLLLfqycLPLlFILVcylriYLRLRRRKDMLERRGEYNRRAghskrinvMLVSLVAAFALCWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 253 PYNIAFFLSTFkEHFSLSDCKssYNLDKSV-HITKLIATthcCINPLLYAFLDGTFSK 309
Cdd:cd15397 240 PLNVFNAIADW-NHEAIPHCQ--HNLIFSLcHLAAMAST---CVNPIIYGFLNSNFKK 291
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
43-168 1.23e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 43.24  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKrVENIYLLNLAVSNLCFLLTLPFWAH-------AGGDPMCKILIGLYFVGLY 115
Cdd:cd14994   6 FLYSVVLIGGVIGVILMSFLLVKMNTRS-VTTTAVINLIVVHSLFLLTVPFRIYyyasktwKFGMPLCKMVSAMIHIHMH 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNFFSARRRVPcGIITSVLAWVTAILATLPEFV 168
Cdd:cd14994  85 LTFLFYVIILVIRYLIFFQRKDKMEFYRKLH-AVAASAVVWVLVLLIVVPVFV 136
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
51-303 1.43e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 42.73  E-value: 1.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  51 IGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAG-------GDPMCKILIGLYFVGLYSETFFNCL 123
Cdd:cd15072  13 VGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSllrrwpyGSEGCQAHGFQGFFTALASICSSAA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 124 LTVQRYLVFLHKGNFFSARrrvpcGIITSVLAWV-TAILATLPEFVVYKPQMEDQKYKCA--FSRtpflpADETFWKHFL 200
Cdd:cd15072  93 IAWDRYHHYCTRSKLQWST-----AISLVLFVWLfSAFWAAMPLLGWGEYDYEPLGTCCTldYSK-----GDRNYVSYLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 201 TlkMNISVLVLPLFIFTFLYVQMRKTLRfREQRYSLFKLVFAIMvvFLLMWAPYNIAFFLSTFKEHFSLSDckssynldK 280
Cdd:cd15072 163 T--MAFFNFILPLFILLTSYSSIEQKLK-KEGHLRFNTGLPLLT--LLICWGPYAILALYAAITDVTSISP--------K 229
                       250       260
                ....*....|....*....|...
gi 68215224 281 SVHITKLIATTHCCINPLLYAFL 303
Cdd:cd15072 230 LRMVPALLAKTSPTINAILYALG 252
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
46-302 2.16e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 42.42  E-value: 2.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKR-VENIYLLNLAVSNLCF-LLTLPFWAhaggdpmCKILIGLYFVGLYSETFFN-- 121
Cdd:cd15057   8 YLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVaILVMPWAA-------VNEVAGYWPFGSFCDVWVSfd 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 -----------CLLTVQRYLVFlhkGNFFSARRRVPC--GIITSVLAWVTAILatlpefVVYKPQMEDQKYKCAFSRTPF 188
Cdd:cd15057  81 imcstasilnlCVISVDRYWAI---SSPFRYERRMTRrrAFIMIAVAWTLSAL------ISFIPVQLGWHRADDTSEALA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADETFWKHFLTLKMNISVLV----LPLFIFTFLYVQMRKTLRFREQRYS-------------------------LFKL 239
Cdd:cd15057 152 LYADPCQCDSSLNRTYAISSSLisfyIPVAIMIVTYTRIYRIARRQIRRIAaleraaqestnpdsslrsslrretkALKT 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68215224 240 VFAIMVVFLLMWAPYNIAFFLSTFkehfslsdCKSSYNLDKSVHITKLIATT-----HCCINPLLYAF 302
Cdd:cd15057 232 LSIIMGVFVCCWLPFFILNCVLPF--------CDLRTAQFPCVPDTTFIVFVwlgwaNSSLNPIIYAF 291
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
48-309 2.25e-04

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 42.57  E-value: 2.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTLPFWAHAG---GDPMCKILIGLYFVGLYSETF 119
Cdd:cd15980  10 IFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLlvgifCMPTTLLDNIIAGwpfGSTVCKMSGMVQGISVSASVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 120 FNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQmEDQKYKCAFS----RTPFLPADETf 195
Cdd:cd15980  90 TLVAIAVDRFRCIVYP---FKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQ-EEKNYRVVLGsqnkTSPVYWCRED- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISVL-----VLPLFIFTFLYVQMRKTL----------RFREQRYS-------LFKLVFAIMVVFLLMWAP 253
Cdd:cd15980 165 WPNQEMRKIYTTVLfaniyLAPLSLIVIMYARIGITLfktamphtgkHNQEQRHVvsrkkqkVIKMLLIVALLFILSWLP 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 254 YNIAFFLStfkEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15980 245 LWTLMMLS---DYANLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
42-314 3.77e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 41.81  E-value: 3.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  42 PSLCSAVFVIGVLD-NLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLP------FWAHAGGDP--MCKILIGLYF 111
Cdd:cd15305   3 PALLILIIIILTIGgNILVIMAVSLEKKLQNATNFFLMSLAVADmLVGILVMPvsliaiLYDYAWPLPryLCPIWISLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 112 VGLYSETFFNCLLTVQRYLVFLH--KGNFFSARRRvpcGIITSVLAWVTAILATLPefvvyKPQMEDQKYKCAFSRTPFL 189
Cdd:cd15305  83 LFSTASIMHLCAISLDRYVAIRNpiEHSRFNSRTK---AMMKIAAVWTISIGISMP-----IPVIGLQDDEKVFVNGTCV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 190 PADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRFR-----EQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFk 264
Cdd:cd15305 155 LNDENF-----VLIGSFVAFFIPLIIMVITYCLTIQVLQRQqainnERRAS--KVLGIVFFLFLIMWCPFFITNILSVL- 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 265 ehfslsdCKSSYN---LDKSVHITKLIATTHCCINPLLYAFLDGT----FSKYLcRC 314
Cdd:cd15305 227 -------CKEACDqklMEELLNVFVWVGYVSSGINPLVYTLFNKTyrraFSNYI-RC 275
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
48-256 4.05e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 41.74  E-value: 4.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL---CFLLTLPFWAHAG-----GDPMCKI------LIGLyfVG 113
Cdd:cd15077  10 LVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLivvCFGSTTAFYSFSQmyfvlGPLACKIegftatLGGM--VS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETffncLLTVQRYLVFLHK-GNFfsaRRRVPCGIITSVLAWVTAILATLPEFVVYKPQM-EDQKYKCAfsrTPFLPA 191
Cdd:cd15077  88 LWSLA----VVAFERFLVICKPlGNF---TFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIpEGLQCSCG---PDWYTT 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 192 DETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRF--REQRYS---------LFKLVFAIMVVFLLMWAPYNI 256
Cdd:cd15077 158 NNKWNNESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAvaKQQEQSastqkaereVTKMVVVMVLGFLVCWLPYAS 233
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
50-302 4.70e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 41.47  E-value: 4.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFwahaggdpmcKILIGLYF-VGLYSETFFNCLL--- 124
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPL----------AILISLGLpTNFHGCLFMACLVlvl 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 125 -----------TVQRYL-VFLHKGNFFSARRRVPCGIITsvLAWVTA-ILATLPEFVVYKP-----QMEDQKYKCAFsrT 186
Cdd:cd14968  82 tqssifsllaiAIDRYLaIKIPLRYKSLVTGRRAWGAIA--VCWVLSfLVGLTPMFGWNNGaplesGCGEGGIQCLF--E 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 187 PFLPAD-ETFWKHFLTlkmnisVLVlPLFIFTFLYV--------QMRKT-----LRFREQRYS----LFKLVFAIMVVFL 248
Cdd:cd14968 158 EVIPMDyMVYFNFFAC------VLV-PLLIMLVIYLrifrvirkQLRQIesllrSRRSRSTLQkevkAAKSLAIILFLFA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 249 LMWAPYNIAFFLSTFkehfslsdCKSSYNLDKSVHITKLIATTHCCINPLLYAF 302
Cdd:cd14968 231 LCWLPLHIINCITLF--------CPECKVPKILTYIAILLSHANSAVNPIVYAY 276
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
40-256 5.32e-04

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 41.31  E-value: 5.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  40 LVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTLPF-----WAHAGGdpMCKILIGL 109
Cdd:cd15296   2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFlvggfCIPLYIPYvltgrWKFGRG--LCKLWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAilatlpeFVVYKPQMEDQKYkcaFSRTPFL 189
Cdd:cd15296  80 DYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLKMVLVWVLA-------FLLYGPAIISWEY---IAGGSII 149
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 190 PADETFWKHFLTLKMNISVLVL----PLFIFTF----LYVQMRKTlRFREQRYSLFKLVFAIMV-VFLLMWAPYNI 256
Cdd:cd15296 150 PEGECYAEFFYNWYFLMTASTLefftPFISVTYfnlsIYLNIQKR-RFRLSRDKKVAKSLAIIVcVFGLCWAPYTL 224
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
48-267 5.65e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 40.98  E-value: 5.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPF---------WAHagGDPMCKILIGLYFVGLYSE 117
Cdd:cd15404  10 ILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLaVLNMPFalvtiittrWIF--GDAFCRVSAMFFWLFVMEG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKGNFFSARRrvpcGIITSVLAWVTAILATLPEFVVYKP-QMEDQKYKCAFSRTpflpaDETFW 196
Cdd:cd15404  88 VAILLIISIDRFLIIVQKQDKLNPYR----AKVLIAVSWAVSFCVAFPLAVGSPDlQIPSRAPQCVFGYT-----TNPGY 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68215224 197 KHFLTLKMNISVLVlPLFIFTFLYVQMRKTLRFREQRysLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHF 267
Cdd:cd15404 159 QAYVILIMLIFFFI-PFMVMLYSFMGILNTVRSFKTR--AFTTILILFIVFTVCWAPFTTYSLVATFNSHF 226
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
43-266 6.42e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 40.94  E-value: 6.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFWAHAG-------GDPMCKILIGLYfVGL 114
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEvldvwifGHTWCQIWLAVD-VWM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFN-CLLTVQRYLVFLHKGNFFS--ARRRVPCGIitsVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPF--L 189
Cdd:cd15063  84 CTASILNlCAISLDRYLAITRPIRYPSlmSTKRAKCLI---AGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPCtcE 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 190 PADETFWKHFLTLkmniSVLVLPLFIFTFLYVQMRKTLRfREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLSTFKEH 266
Cdd:cd15063 161 LTNGRGYVIYSAL----GSFYIPMLVMLFFYFRIYRAAR-METKAA--KTVAIIVGCFIFCWLPFFTVYLVRAFCED 230
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
48-254 6.60e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 40.91  E-value: 6.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT---LPFWAHAGGDPMCKILIGLYFVGLYSET--FFNC 122
Cdd:cd15358  10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgmpLELYEMWSNYPFLLGAGGCYFKTLLFETvcFASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 123 L----LTVQRYLVFLH--KGNFFSARRRVPCGIITsvlAWVTAILATLPEFVVYKPQmedqkYKCAFSRTPFL-PADETF 195
Cdd:cd15358  90 LnvtaLSVERYIAVVHplKAKYVVTRTHAKRVIGA---VWVVSILCSIPNTSLHGIF-----QLTVPCRGPVPdSATCML 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKMNISV-----LVLPLFIFTFLY----VQMRK-------------------TLRFREQ---RYSLFKLVFAIM 244
Cdd:cd15358 162 VKPRWMYNLIIQIttllfFFLPMGTISVLYlligLQLKRekmllvleakgskagdsyqHRRIQQEkrrRRQVTKMLFVLV 241
                       250
                ....*....|
gi 68215224 245 VVFLLMWAPY 254
Cdd:cd15358 242 VVFGICWAPF 251
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
56-311 8.06e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 40.82  E-value: 8.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  56 NLLVVLILVKYKGLKR-VENIYLLNLAVSNLCFLLTLPFWA--------HAGGD-----PMCkILIGLYFVGLYSETffn 121
Cdd:cd15104  17 NLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLAtdellsdgENTQKvlcllRMC-FVITSCAASVLSLA--- 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 122 cLLTVQRYLVF---LHKGNFFSARRRVPCgiitSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFsrtpflpaDETFWKH 198
Cdd:cd15104  93 -AIAFDRYLALkqpLRYKQIMTGKSAGAL----IAGLWLYSGLIGFLPLISPQFQQTSYKGKCSF--------FAAFHPR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 199 FLTLKMniSVLVLP-LFIFTFLYVQMRKT---------------LRFREQRY--SLFKLVFAIMVV---FLLMWAPYNIA 257
Cdd:cd15104 160 VLLVLS--CMVFFPaLLLFVFCYCDILKIarvhsraiykvehalARQIHPRRtlSDFKAARTVAVLigcFLLSWLPFQIT 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 68215224 258 FFLSTFkehfslsdCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15104 238 GLVQAL--------CDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
75-303 1.37e-03

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 39.93  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  75 IYLLNLAVSNLCFLL---------TLPFwaHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLhkgnF---FSAR 142
Cdd:cd14973  36 VYILNLAAADFLFLScqaiqsledLLGG--SLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVL----FpiwYRCH 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 143 RRVPCGIITSVLAWVTAILATLPEFvvykpqmedqkYKCAFSrtpFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQ 222
Cdd:cd14973 110 RPKHLSAVVCALLWALSLLLSVLES-----------YFCGFL---FWKFNESACRTFNFLSALLFLLLFLVMCVSSLTLL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 223 MRKTLRFREQRYS-LFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCkssynldksVHITKLIATTHCCINPLLYA 301
Cdd:cd14973 176 IRVQCSSQRRPPTrLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNYLFHTF---------HPISDLLSCVNSSANPIIYF 246

                ..
gi 68215224 302 FL 303
Cdd:cd14973 247 FV 248
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
56-313 1.66e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 39.82  E-value: 1.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  56 NLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLP------FWAHAGGDPMCKILIGLYFVGLYS--ETFFNCLLTV 126
Cdd:cd15306  18 NILVILAVSLEKKLQYATNYFLMSLAVADLLVgLFVMPialltiLFEAMWPLPLVLCPIWLFLDVLFStaSIMHLCAISL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 127 QRYLVFLH--KGNFFSARRRVpcgIITSVLAWVTAILATLPEFV--VYKPQMEDQKYKCAFSRTPFlpadetfwkHFLTL 202
Cdd:cd15306  98 DRYIAIKKpiQASQYNSRATA---FIKITVVWLISIGIAIPVPIkgIETDVDNPNNITCVLTKERF---------GDFIL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 203 KMNISVLVLPLFIFT---FLYVQ-MRKTLRFREQRYSlfKLVFAIMVVFLLMWAPyniaFFLSTFKEhfSLSDCKSSYNL 278
Cdd:cd15306 166 FGSLAAFFTPLAIMIvtyFLTIHaLRKQTITNEQRAS--KVLGIVFFLFLLMWCP----FFITNITS--VLCDSCNQTTL 237
                       250       260       270
                ....*....|....*....|....*....|....*
gi 68215224 279 DKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCR 313
Cdd:cd15306 238 QMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
44-307 1.71e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.53  E-value: 1.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF-LLTLPFwahaggdPMCKILIG--------LYFVGL 114
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLgFLVMPV-------SMLTILYGyrwplpskLCAVWI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFN-------CLLTVQRYLVF---LHKGNfFSARRRVPCGIITsvlAWVTAILATLPefvvyKPQMEDQKYKCAFS 184
Cdd:cd15304  79 YLDVLFStasimhlCAISLDRYIAIrnpIHHSR-FNSRTKAFLKIIA---VWTISVGISMP-----IPVFGLQDDSKVFK 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 185 RTPFLPADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLR---FREQRYSlfKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd15304 150 EGSCLLADENF-----VLIGSFVAFFIPLTIMVITYFLTIKSLQqsiSNEQKAS--KVLGIVFFLFVVMWCPFFITNVMA 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 262 TFkehfslsdCKSSYN---LDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15304 223 VI--------CKESCNevvIGGLLNVFVWIGYLSSAVNPLVYTLFNKTY 263
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
46-309 1.95e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 39.47  E-value: 1.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFVGLY 115
Cdd:cd15324   8 VVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADiLVATLVIPFslanevmgyWYF--GSTWCAFYLALDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLH--KGNFFSARRRVPCGIitsVLAWVTAILATLPEFVVYKpqmeDQKYKCafsrtpfLPADE 193
Cdd:cd15324  86 SSIVHLCAISLDRYWSVTKavSYNLKRTPKRIKRMI---AVVWVISAVISFPPLLMTK----HDEWEC-------LLNDE 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 194 TFWkhflTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVfaIMVVFLLMWAPYniaFFlsTFKEHfslSDCK 273
Cdd:cd15324 152 TWY----ILSSCTVSFFAPGLIMILVYCKIYRVAKMREKRFTFVLAV--VMGVFVLCWFPF---FF--TYSLH---AVCR 217
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 68215224 274 SSYNLDKSV-HITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15324 218 KRCGIPDALfNLFFWIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
46-307 2.31e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 39.11  E-value: 2.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  46 SAVFVIGVLDNLLVVLILVKYKGLKRVENI-YLLNLAVSNLCFLLTLPFWAHAGGD---------PMCKILIGLYFVGLY 115
Cdd:cd15919   8 SLLLCLGLPANILTVIILSQLVARRQKSSYnYLLALAAADILVLFFIVFVDFLLEDfilnkqmpqVLDKIIEVLEFSSIH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 116 SETFFNCLLTVQRYLVFLHKGNF----FSARRRvpcGIITSVlaWVTAILATLPEFvvYKPQMEDQKYKcafsrtpflpa 191
Cdd:cd15919  88 TSIWITVPLTIDRYIAVCHPLKYhtvsYPARTR---KVIVSV--YITCFLTSIPYY--WWPNIWIEDYT----------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 dETFWKHFLTLKMNISVLVLPLFIF----TFLYVQMRKTLRFREQRYSLFK---LVFAIMVVFLLMWAPYNIAFFLstfk 264
Cdd:cd15919 150 -STSMHHVLIWIHCFTVYLVPCSIFfvlnSIIVYKLRRKSNFRLRGYSTGKttaILFTITSIFAILWAPRIIMILY---- 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 68215224 265 eHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTF 307
Cdd:cd15919 225 -HLYVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRF 266
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
44-315 2.89e-03

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 39.07  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLT-------------LPFWAHAGGDPMCKILIGLY 110
Cdd:cd15975   6 LSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIdipinvykllaqkWPFDDSSFGVFLCKLVPFLQ 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHkgnfFSARRRVPCGIITSV---LAWVTAILATLPEFVVYkpQMEDQKYKCAFSRTP 187
Cdd:cd15975  86 KASVGITVLNLCALSVDRYRAVAS----WSRVQGIGIPLITAIeifSIWVLSFILAIPEAIGF--VMVPFEYNGEQYRTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 188 FLPADETFWKHFLTLK---MNISVLVLPLFIFTFLYVQM--------RKTLRFR-----EQRYSLFKLVFAIMVVFLLMW 251
Cdd:cd15975 160 MLNATTKFMNFYVDAKdwwLFGFYFCVPLACTAIFYTLMtcemlnrrKGSLRIAlsehlKQRREVAKTVFCLVVIFALCW 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 252 APYNIAFFL-STFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLdgtfSKYLCRCF 315
Cdd:cd15975 240 FPLHLSRILkKTVYNENDPRRCELLSFLLVMDYISINLATMNSCINPIALYFV----SKKFKNCF 300
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
49-265 4.20e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 38.27  E-value: 4.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  49 FVIgVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-----LCFLLTLPF-----WAHagGDPMCKILIGLYFVGLYSET 118
Cdd:cd15295  12 LVI-VLGNALVIIAFVVDKNLRHRSNYFFLNLAISDffvgaISIPLYIPYtltnrWDF--GRGLCVFWLVIDYLLCTASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 119 FFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKpQMEDQKYKCafsrtpflpADETFWKH 198
Cdd:cd15295  89 YNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVAVWVLAFLVHGPAILVSD-SWKTEDGEC---------EPEFFSNW 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68215224 199 FLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKE 265
Cdd:cd15295 159 YILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRDRKLAKSLAIILGTFAICWAPYSLFTIIRAACE 225
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
44-228 4.68e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 38.47  E-value: 4.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  44 LCSAVFVIGV--LDNLLVVLILVKYKGLKRVENIYLLNLAVSN-----LCFLLTL------PFWAHagGDPMCKILIGLY 110
Cdd:cd15218   4 LTSLGFIIGVsvVGNLLISILLVKDKTLHRAPYYFLLDLCCSDilrsaICFPFVFtsvkngSTWTY--GTLTCKVIAFLG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 111 FVGLYSETFFNCLLTVQRYLVFLHKgNFFSARRRVPCGIITSVLAWVTAILATLPEFV-VYKPQMEDQKYKCAFSRTPFL 189
Cdd:cd15218  82 VLSCFHTAFMLFCISVTRYLAIAHH-RFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLdVGTYSFIREEDQCTFQHRSFR 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 68215224 190 PADETFWKHFLTLKMNISVLVLPLFIFtflYVQMRKTLR 228
Cdd:cd15218 161 ANDSLGFMLLLALILLATQLVYLKLIF---FVHDRRKMK 196
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
43-309 6.04e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 38.01  E-value: 6.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  43 SLCSAVFVIGVL-DNLLVVLILVKYKGLKRVENIYLLNLAVSNLCF--------LLTLPFWAHAGGDPMCKILIGLYFVG 113
Cdd:cd15307   4 ALLALVLVLGTAaGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVavlvmplgILTLVKGHFPLSSEHCLTWICLDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 114 LYSETFFNCLLTVQRYLVFLHKGNF--FSARRRVPCGIitsVLAWVTAILATLPEFVVYKpqmeDQKYKCAFSRTPFLPA 191
Cdd:cd15307  84 CTASIMHLCTISVDRYLSLRYPMRFgrNKTRRRVTLKI---VFVWLLSIAMSLPLSLMYS----KDHASVLVNGTCQIPD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 192 DetfwkhFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLF--------KLVFAIMVVFLLMWAPYNIAFFLST- 262
Cdd:cd15307 157 P------VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIirleqkatKVLGVVFFTFVILWSPFFVLNLLPTv 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 68215224 263 ---FKEHFSlsdckssynlDKSVHITKLIATTHCCINPLLYAFLDGTFSK 309
Cdd:cd15307 231 caeCEERIS----------HWVFDVVTWLGYASSMVNPIFYTIFNKVFRQ 270
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
41-302 6.17e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 37.84  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIgvLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCflltlpfwahAGGDPMCKILI------------- 107
Cdd:cd15349   5 VLFICISVLII--LENLLVLLAILRRVRLRRWVYICLANIALSDLL----------TGTSYLVNICLsgertfrltpalw 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 108 ----GLYFVGLYSETFFNCLLTVQRY--LVFLHKGNFFSARRRVPCGIitsVLAWVTAILatlpefVVYKPQMeDQKYKC 181
Cdd:cd15349  73 flreGLLFTALAASTFSLLVTAVERYatMVRPVAENTATKTYRVYGMI---VLCWILAFL------IGFLPLL-GWNCLC 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 182 AFSR-TPFLPADETFWKHFLTLKMNISVL---VLPLFIFTFLYVQMRKTLRFREQRYS--LFKLVFAIMVVFLLMWAPYN 255
Cdd:cd15349 143 DFRScSSLLPLYSKSYILFCLVIFFIILLtiiGLYFAIYCLVRASGQRVISARSRRRSlrLLKTVLMILGAFMVCWGPLF 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 68215224 256 IAFFLSTFKEHFSlsdCKSSYNLDKSVhitkLIATTHCCINPLLYAF 302
Cdd:cd15349 223 ILLLVDFFCSSRS---CKPLFGMEWVL----ALAVLNSAINPLIYSF 262
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
39-311 7.02e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 37.85  E-value: 7.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTlpfwahAGGDPMCKILIGLYFVGL---- 114
Cdd:cd15082  14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLT------GGTISFLTNARGYFFLGVwacv 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 ---YSETFFN-------CLLTVQRYLVFLHK-GNFFSARRRVPCGIItsvLAWVTAILATLPefvvykPQMEDQKYKCAF 183
Cdd:cd15082  88 legFAVTFFGivalwslAVLAFERFFVICRPlGNIRLQGKHAALGLL---FVWTFSFIWTIP------PVLGWSSYTVSK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 184 SRTPFLP-------ADETFWKHFLTlkmniSVLVLPLFIFTFLYVQMRKTLR-----------FREQRYSLFKLVFAIMV 245
Cdd:cd15082 159 IGTTCEPnwysgnmHDHTYIITFFT-----TCFILPLGVIFVSYGKLLQKLRkvsntqgrlgnARKPERQVTRMVVVMIV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68215224 246 VFLLMWAPYNIAFFLSTfkehfslsDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15082 234 AFMVCWTPYAAFSILVT--------AHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
48-179 7.22e-03

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 37.88  E-value: 7.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL-----CFLLTL--------PFwahagGDPMCKILIGLYFVGL 114
Cdd:cd15981  10 IFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLlvgifCMPTTLvdnlitgwPF-----DNAMCKMSGLVQGMSV 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKY 179
Cdd:cd15981  85 SASVFTLVAIAVERFRCIVHP---FRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHF 146
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-310 7.29e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 37.52  E-value: 7.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  50 VIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNL----CFLLTLPFWAHAG----GDPMCkILIGL---YF--VGLYS 116
Cdd:cd15085  12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLmmalCGTTIVTVTNYEGyfylGDAFC-IFQGFavnYFgiVSLWS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 117 ETffncLLTVQRYLVFLHKGNFFSARRRVPCGIItsVLAWVTAIL-ATLPEFVVYKPQMEDQKYKCAfsrtpfLPADETF 195
Cdd:cd15085  91 LT----LLAYERYNVVCKPMGGLKLSTKRGYQGL--LFIWLFCLFwAVAPLFGWSSYGPEGVQTSCS------IGWEERS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 196 WKHFLTLKM-NISVLVLPLFIFTFLYVQMRKTLR-------------FREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLS 261
Cdd:cd15085 159 WSNYSYLILyFLMCFVIPVAIIGFSYGNVLRSLHklnkkieqqggknCPEEEERAVIMVLAMVIAFLICWLPYTVFALIV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 68215224 262 TFKEHFSLSDCKSSynldksvhITKLIATTHCCINPLLYAFLDGTFSKY 310
Cdd:cd15085 239 VVNPELSISPLAAT--------MPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
45-311 8.02e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 37.43  E-value: 8.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  45 CSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFVGL 114
Cdd:cd15317   7 LVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADfLLGLCVMPFsmirtvetcWYF--GDLFCKFHTGLDLLLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 115 YSETFFNCLLTVQRYLVFLHKgnffsarRRVPCGIITSVlAW----VTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLP 190
Cdd:cd15317  85 TTSIFHLCFIAIDRYYAVCDP-------LRYPSKITVQV-AWrfiaIGWLVPGIYTFGLIYTGANDEGLEEYSSEISCVG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 191 ADETFWKHFLTLkMNISVLVLPLFIFTFLYVQ--------------MRKTLRFREQRYSLF---------KLVFAIMVVF 247
Cdd:cd15317 157 GCQLLFNKIWVL-LDFLTFFIPCLIMIGLYAKiflvarrqarkiqnMEDKFRSSEENSSKAsasrerkaaKTLAIVMGIF 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68215224 248 LLMWAPYNIAFFLSTFKeHFSLSDCkssynldkSVHITKLIATTHCCINPLLYAFLDGTFSKYL 311
Cdd:cd15317 236 LFCWLPYFIDTIVDEYS-NFITPAI--------VFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
39-157 8.13e-03

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 37.68  E-value: 8.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  39 QLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVEN-IYLLNLAVSNLCFLLTLPF---WAHAGGD-----PMCKILIGL 109
Cdd:cd15169   1 QLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSlVYALNLGCSDLLLTVSLPLkavEALASGAwplpaSLCPVFAVA 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 68215224 110 YFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRrvPC---GIITSVLAWV 157
Cdd:cd15169  81 HFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRR--PCyswGVCAAIWALV 129
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
48-304 8.13e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 37.44  E-value: 8.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  48 VFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSN-LCFLLTLPF---------WAHagGDPMCKILIGLYFVGLYSE 117
Cdd:cd15398  10 ISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDiLVVLFCSPFtltcvlldqWIF--GEVMCHIVPFLQCVSVMVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 118 TFFNCLLTVQRYLVFLHKgnfFSARRRVPCGIITSVLAWVT--AILATLPEF-------VVYKPQMEDQKYKCAFSrtpf 188
Cdd:cd15398  88 TLMLMSIAIVRYHMIKHP---LSNHLTANHGYFLLGTVWTLgfTICSPLPVFhkivdlsETFNLESLKNKYLCIES---- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 189 LPADEtfWKHFLTLKMNISVLVLPLFIFTFLYVQMRKtlRFREQRYSLFKLVFAIMVvFLLMWAPYNIAFFLSTFK---- 264
Cdd:cd15398 161 WPSDS--YRIAFTISLLFVQYILPLVCLTVSHTSVCR--SVKRSRSVFYRLTIVILA-FAVSWMPLHLFHLVTDFNanli 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 68215224 265 --EHFSLSDCkssynldksvhITKLIATTHCCINPLLYAFLD 304
Cdd:cd15398 236 snRHFKLVYC-----------ICHLLGMLSCCLNPILYGFLN 266
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
41-311 9.18e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 37.53  E-value: 9.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  41 VPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLC---FLLTLPFWAHAG-----GDPMCKI------L 106
Cdd:cd15084  13 VAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLvtlFGSSVSFSNNIVgffvfGKTMCEFegfmvsL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 107 IGLyfVGLYSETffncLLTVQRYLVFLHK-GNFFSARRRvpcGIITSVLAWVTAILATLPEFV---VYKPqmEDQKYKCA 182
Cdd:cd15084  93 TGI--VGLWSLA----ILAFERYLVICKPmGDFRFQQRH---AVSGCAFTWGWSLLWTSPPLFgwsSYVP--EGLRTSCG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 183 FSRTPFLPADETFwkhflTLKMNISVLVLPLFIFTFLYVQMRKTLR--FREQRYS---------LFKLVFAIMVVFLLMW 251
Cdd:cd15084 162 PNWYTGGTNNNSY-----ILALFVTCFALPLSTIIFSYSNLLLTLRavAAQQKESettqraekeVTRMVIAMVMAFLICW 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68215224 252 APY-NIAFFLSTFKE---HFSLSDCKSSYNLDKSVHitkliatthcciNPLLYAFLDGTFSKYL 311
Cdd:cd15084 237 LPYaTFAMVVATNKDvviQPTLASLPSYFSKTATVY------------NPIIYVFMNKQFRSCL 288
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
75-302 9.90e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 37.38  E-value: 9.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224  75 IYLLNLAVSNLCFLL---------TLPFWAHAGGDPMCKILIGLYFVGLYSETFFncLLT---VQRYLVFLHKGNFFSAR 142
Cdd:cd15110  36 VYILHLAIADFTFLLcifilsimyIGPFNFSHSRDYVAMLIFIILFLFGYNTGLY--LLTaisVERCLSVLYPIWYRCHR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 143 RRVPCGIITSVLaWVTAILATLPEFVVYKPQMEDQKYKCAFSrtpflpadetfwkhFLTLKMNISVLVLPLFIF--TFLY 220
Cdd:cd15110 114 PKHQSAIVCGLL-WALSVLMTSLEYLMCIDEGFHVRNECRAV--------------LIFIGILTFLVFTPLMLIssLILF 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68215224 221 VQMRKTLRfREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKehfslsdcksSYNLDKSVHITKLIATTHCCINPLLY 300
Cdd:cd15110 179 IKVRCNSQ-RRHPGKLYIIIMLTVIFFLIFAMPMRVLLLLNYLH----------HSSFLFSNPVPFLLSTVNSSINPIVY 247

                ..
gi 68215224 301 AF 302
Cdd:cd15110 248 FL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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