NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|681104028|emb|CDZ74287|]
View 

Histidine kinase [Peptoniphilus sp. ING2-D1G]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-318 8.28e-44

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 152.75  E-value: 8.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  26 VVFFVVLYSRNINVSSIFYALLISFAVLFLCSLYFYGRYKLNYLSLIDFLNSDEINLKVDFSDPVYKLLAQGIRDYKIQK 105
Cdd:COG0642   13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 106 TNFISDDRKRLDEINK----FYTMWTHQIKTPIAALNLMLE-------DKNESDLKI---EVMKIEDYVNMLLAYYRNNS 171
Cdd:COG0642   93 LLLLLALLLLLEEANEaksrFLANVSHELRTPLTAIRGYLEllleeldEEQREYLETilrSADRLLRLINDLLDLSRLEA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 172 PTTDYSFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKYTKSG-EITI-ISAE 247
Cdd:COG0642  173 GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNLLSNAIKYTPEGgTVTVsVRRE 252
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 681104028 248 N---FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYtKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG0642  253 GdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-318 8.28e-44

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 152.75  E-value: 8.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  26 VVFFVVLYSRNINVSSIFYALLISFAVLFLCSLYFYGRYKLNYLSLIDFLNSDEINLKVDFSDPVYKLLAQGIRDYKIQK 105
Cdd:COG0642   13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 106 TNFISDDRKRLDEINK----FYTMWTHQIKTPIAALNLMLE-------DKNESDLKI---EVMKIEDYVNMLLAYYRNNS 171
Cdd:COG0642   93 LLLLLALLLLLEEANEaksrFLANVSHELRTPLTAIRGYLEllleeldEEQREYLETilrSADRLLRLINDLLDLSRLEA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 172 PTTDYSFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKYTKSG-EITI-ISAE 247
Cdd:COG0642  173 GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNLLSNAIKYTPEGgTVTVsVRRE 252
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 681104028 248 N---FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYtKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG0642  253 GdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
216-319 2.43e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 139.73  E-value: 2.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 216 SDSKWLEFIISQLISNSLKYTK-SGEITIISAEN----FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKSTGIGLNL 290
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKqGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80
                         90       100
                 ....*....|....*....|....*....
gi 681104028 291 VKSVADNLNIDIEVDSNVGEGTTVKLKFN 319
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
217-318 9.84e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.48  E-value: 9.84e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028   217 DSKWLEFIISQLISNSLKYTKS-GEITII----SAENFISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKSTGIGLNLV 291
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEgGRITVTlerdGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81
                           90       100
                   ....*....|....*....|....*..
gi 681104028   292 KSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
217-318 1.21e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.42  E-value: 1.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  217 DSKWLEFIISQLISNSLKYT-KSGEITI-ISAENF--ISIKDTGIGIEKSDLPRIFELGFTGYNGRiyTKSTGIGLNLVK 292
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAaKAGEITVtLSEGGEltLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIVR 79
                          90       100
                  ....*....|....*....|....*.
gi 681104028  293 SVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTL 105
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
113-316 3.41e-18

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 85.02  E-value: 3.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 113 RKRLDEINKFYTMWTHQIKTPIA--ALNLMLEdknesdlkiEVMKIEDYVNMLLAYYRNNSPttdySFSKVRLDDVIRSS 190
Cdd:PRK11360 402 RNPLTAIRGYVQIWRQQTSDPPSqeYLSVVLR---------EVDRLNKVIDQLLEFSRPRES----QWQPVSLNALVEEV 468
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 191 VRKYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLK-YTKSGEITI-----ISAENFISIKDTGIGIEKS 262
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINAVQaISARGKIRIrtwqySDGQVAVSIEDNGCGIDPE 548
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 681104028 263 DLPRIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKL 316
Cdd:PRK11360 549 LLKKIFDPFFT-------TKAkgTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
26-318 8.28e-44

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 152.75  E-value: 8.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  26 VVFFVVLYSRNINVSSIFYALLISFAVLFLCSLYFYGRYKLNYLSLIDFLNSDEINLKVDFSDPVYKLLAQGIRDYKIQK 105
Cdd:COG0642   13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 106 TNFISDDRKRLDEINK----FYTMWTHQIKTPIAALNLMLE-------DKNESDLKI---EVMKIEDYVNMLLAYYRNNS 171
Cdd:COG0642   93 LLLLLALLLLLEEANEaksrFLANVSHELRTPLTAIRGYLEllleeldEEQREYLETilrSADRLLRLINDLLDLSRLEA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 172 PTTDYSFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKYTKSG-EITI-ISAE 247
Cdd:COG0642  173 GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNLLSNAIKYTPEGgTVTVsVRRE 252
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 681104028 248 N---FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYtKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG0642  253 GdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
216-319 2.43e-41

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 139.73  E-value: 2.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 216 SDSKWLEFIISQLISNSLKYTK-SGEITIISAEN----FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKSTGIGLNL 290
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKqGGKIEIYSETNeqgvVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80
                         90       100
                 ....*....|....*....|....*....
gi 681104028 291 VKSVADNLNIDIEVDSNVGEGTTVKLKFN 319
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
109-318 3.65e-37

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 133.11  E-value: 3.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 109 ISDDRKRLDEINKFYTMW----THQIKTPIAALNL---MLEDKNESD----------LKIEVMKIEDYVNMLLAYYRNNS 171
Cdd:COG2205    2 LEEALEELEELERLKSEFlanvSHELRTPLTSILGaaeLLLDEEDLSpeerrelleiIRESAERLLRLIEDLLDLSRLES 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 172 PTTDYSFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDL--KEAVVISDSKWLEFIISQLISNSLKYTKSG---EITIISA 246
Cdd:COG2205   82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPPGgtiTISARRE 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 681104028 247 ENF--ISIKDTGIGIEKSDLPRIFELGFTGYNGRiYTKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG2205  162 GDGvrISVSDNGPGIPEEELERIFERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
128-318 2.52e-30

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 118.50  E-value: 2.52e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIAALNL---MLEDKNESD-------LKI---EVMKIEDYVNMLLAYYRNNSPTTDYSFSKVRLDDVIRSSVRKY 194
Cdd:COG5002  174 HELRTPLTSIRGyleLLLDGAADDpeerreyLEIileEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEEL 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 195 ADVFIKNKIKIKVDLKE--AVVISDSKWLEFIISQLISNSLKYTKSGEITIISAEN-----FISIKDTGIGIEKSDLPRI 267
Cdd:COG5002  254 RPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREeddqvRISVRDTGIGIPEEDLPRI 333
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 681104028 268 FELGFTGYNGRIYTKS-TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG5002  334 FERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
217-318 9.84e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.48  E-value: 9.84e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028   217 DSKWLEFIISQLISNSLKYTKS-GEITII----SAENFISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKSTGIGLNLV 291
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEgGRITVTlerdGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81
                           90       100
                   ....*....|....*....|....*..
gi 681104028   292 KSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITL 108
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
156-314 2.16e-21

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 94.47  E-value: 2.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 156 IEDyvnmLLAYYRNNspTTDYSFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDlKEAVVISDSKWLEFIISQLISNSLKY 235
Cdd:COG4251  337 IDD----LLAYSRVG--RQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKY 409
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 236 TKSG-----EITIISAENF--ISIKDTGIGIEKSDLPRIFELgFTGYNGRIYTKSTGIGLNLVKSVADNLNIDIEVDSNV 308
Cdd:COG4251  410 SRPGeppriEIGAEREGGEwvFSVRDNGIGIDPEYAEKIFEI-FQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEP 488

                 ....*.
gi 681104028 309 GEGTTV 314
Cdd:COG4251  489 GEGATF 494
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
217-318 1.21e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.42  E-value: 1.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  217 DSKWLEFIISQLISNSLKYT-KSGEITI-ISAENF--ISIKDTGIGIEKSDLPRIFELGFTGYNGRiyTKSTGIGLNLVK 292
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAaKAGEITVtLSEGGEltLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIVR 79
                          90       100
                  ....*....|....*....|....*.
gi 681104028  293 SVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTL 105
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
127-318 1.39e-19

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 88.48  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 127 THQIKTPIAALNLMLE-------DKNESDLKI----------EVMKIEDYVNMLLAYYRNNSPTtdysFSKVRLDDVIRS 189
Cdd:COG5000  209 AHEIKNPLTPIQLSAErlrrklaDKLEEDREDleraldtiirQVDRLKRIVDEFLDFARLPEPQ----LEPVDLNELLRE 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 190 SVRKYADVFIKNKIKIKVDLKEA--VVISDSKWLEFIISQLISNSLKYTKS-GEITIISAEN----FISIKDTGIGIEKS 262
Cdd:COG5000  285 VLALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNAIEAIEEgGEIEVSTRREdgrvRIEVSDNGPGIPEE 364
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 681104028 263 DLPRIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG5000  365 VLERIFEPFFT-------TKPkgTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
224-316 5.36e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 81.00  E-value: 5.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYTKSGEITI-ISAENF--------ISIKDTGIGIEKSDLPRIFElGFT---GYNGRIYTkSTGIGLNLV 291
Cdd:cd16922    4 ILLNLLGNAIKFTEEGEVTLrVSLEEEeedgvqlrFSVEDTGIGIPEEQQARLFE-PFSqadSSTTRKYG-GTGLGLAIS 81
                         90       100
                 ....*....|....*....|....*
gi 681104028 292 KSVADNLNIDIEVDSNVGEGTTVKL 316
Cdd:cd16922   82 KKLVELMGGDISVESEPGQGSTFTF 106
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
128-318 1.42e-18

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 85.24  E-value: 1.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIAA-------LNLMLEDKNESD--------LKIEVMKIEDYVNMLLAYYRNNSPTtdysFSKVRLDDVIRSSVR 192
Cdd:COG4191  151 HEINNPLAAilgnaelLRRRLEDEPDPEelrealerILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALE 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 193 KYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNS---LKYTKSGEITIISAEN----FISIKDTGIGIEKSD 263
Cdd:COG4191  227 LLRPRLKARGIEVELDLPPDLppVLGDPGQLEQVLLNLLINAidaMEEGEGGRITISTRREgdyvVISVRDNGPGIPPEV 306
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 681104028 264 LPRIFELGFTgyngriyTKS----TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG4191  307 LERIFEPFFT-------TKPvgkgTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
113-316 3.41e-18

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 85.02  E-value: 3.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 113 RKRLDEINKFYTMWTHQIKTPIA--ALNLMLEdknesdlkiEVMKIEDYVNMLLAYYRNNSPttdySFSKVRLDDVIRSS 190
Cdd:PRK11360 402 RNPLTAIRGYVQIWRQQTSDPPSqeYLSVVLR---------EVDRLNKVIDQLLEFSRPRES----QWQPVSLNALVEEV 468
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 191 VRKYADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLK-YTKSGEITI-----ISAENFISIKDTGIGIEKS 262
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDNELppIWADPELLKQVLLNILINAVQaISARGKIRIrtwqySDGQVAVSIEDNGCGIDPE 548
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 681104028 263 DLPRIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKL 316
Cdd:PRK11360 549 LLKKIFDPFFT-------TKAkgTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
128-318 3.22e-15

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 75.27  E-value: 3.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIA----ALNLMLEDKNESDLK--IEVMK-----IEDYVNMLLAYYRNNSPttdySFSKVRLDDVIRSsVRKYAD 196
Cdd:COG3852  144 HEIRNPLTgirgAAQLLERELPDDELReyTQLIIeeadrLNNLVDRLLSFSRPRPP----EREPVNLHEVLER-VLELLR 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 197 VFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKY-TKSGEITIISAENF--------------ISIKDTGIGI 259
Cdd:COG3852  219 AEAPKNIRIVRDYDPSLpeVLGDPDQLIQVLLNLVRNAAEAmPEGGTITIRTRVERqvtlgglrprlyvrIEVIDNGPGI 298
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 681104028 260 EKSDLPRIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG3852  299 PEEILDRIFEPFFT-------TKEkgTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
128-318 6.30e-15

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 75.01  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIAAL----NLMLEDKN-ESDLKIEVM-----KIEDYVNMLLAYYRNnsptTDYSFSKVRLDDVIRSsvrkYADV 197
Cdd:COG5809  279 HEIRNPLTSLkgfiQLLKDTIDeEQKTYLDIMlseldRIESIISEFLVLAKP----QAIKYEPKDLNTLIEE----VIPL 350
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 198 F----IKNKIKIKVDL--KEAVVISDSKWLEFIISQLISNSLKYTKS-GEITI-ISAEN----FISIKDTGIGIEKSDLP 265
Cdd:COG5809  351 LqpqaLLKNVQIELELedDIPDILGDENQLKQVFINLLKNAIEAMPEgGNITIeTKAEDddkvVISVTDEGCGIPEERLK 430
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 681104028 266 RIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG5809  431 KLGEPFYT-------TKEkgTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
128-318 1.23e-13

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 71.30  E-value: 1.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIAA----LNLMLEDKNESDLKIEVM-----KIEDYVNMLLAYYRNNSpttdYSFSKVRLDDVIRSSVRKYADVF 198
Cdd:COG5805  296 HEIRNPLTSikgfLQLLQPGIEDKEEYFDIMlseldRIESIISEFLALAKPQA----VNKEKENINELIQDVVTLLETEA 371
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 199 IKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKYTKS-GEITIISAEN----FISIKDTGIGIEKSDLPRIFELG 271
Cdd:COG5805  372 ILHNIQIRLELLDEDpfIYCDENQIKQVFINLIKNAIEAMPNgGTITIHTEEEdnsvIIRVIDEGIGIPEERLKKLGEPF 451
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 681104028 272 FTgyngrIYTKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG5805  452 FT-----TKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
214-316 2.33e-13

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 70.74  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 214 VISDSKWLEFIISQLISNSLKYTKSGEITI-ISAENFIS----IKDTGIGIEKSDLPRIFELGF--TGYNGRIYTKSTGI 286
Cdd:PRK11091 392 VITDGTRLRQILWNLISNAVKFTQQGGVTVrVRYEEGDMltfeVEDSGIGIPEDELDKIFAMYYqvKDSHGGKPATGTGI 471
                         90       100       110
                 ....*....|....*....|....*....|
gi 681104028 287 GLNLVKSVADNLNIDIEVDSNVGEGTTVKL 316
Cdd:PRK11091 472 GLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
127-321 3.90e-12

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 66.79  E-value: 3.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 127 THQIKTPIAAL----NLMLEDKNESDLK-----I--EVMKIEDYVNMLLAYYRNNSPTTDYSFSKVRLDDVIRSSVRKYA 195
Cdd:PRK11100 264 THELKSPLAAIrgaaELLQEDPPPEDRArftgnIltQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEARE 343
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 196 DVFIKNKIKIKVDLKEAVVISDSKWLEFIISQLISNSLKYTKSG-EITIiSAEN-----FISIKDTGIGIEKSDLPRIFE 269
Cdd:PRK11100 344 AQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGgTITL-SAEVdgeqvALSVEDQGPGIPDYALPRIFE 422
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 270 lgftgyngRIYT--------KSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKFNNR 321
Cdd:PRK11100 423 --------RFYSlprpangrKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
177-318 4.16e-12

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 66.47  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 177 SFSKVRLDDVIRSSVRKYADVFIKNKIKIKVDLKE-------AVVISdskwleFIISQLISNSLKY----TKSGEITI-- 243
Cdd:COG3920  355 DWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDvelpadaAVPLG------LILNELVTNALKHaflsGEGGRIRVsw 428
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 681104028 244 -ISAENF-ISIKDTGIGieksdLPRIFELgftgyngriyTKSTGIGLNLVKSVADNLNIDIEVDSnvGEGTTVKLKF 318
Cdd:COG3920  429 rREDGRLrLTVSDNGVG-----LPEDVDP----------PARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITF 488
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
204-318 5.23e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 62.94  E-value: 5.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 204 KIKVDLKEAVVISDSKWLEF----IISQLISNSLKYTKSG-------EITIISAENF--ISIKDTGIGIEKSDLPRIFEL 270
Cdd:COG3290  261 GIDLTIDIDSDLPDLPLSDTdlvtILGNLLDNAIEAVEKLpeeerrvELSIRDDGDElvIEVEDSGPGIPEELLEKIFER 340
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 681104028 271 GFTgyngriyTKS---TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG3290  341 GFS-------TKLgegRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
214-318 3.27e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 56.65  E-value: 3.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 214 VISDSKWLEFIISQLISNSLKYTKSGEITIISAENF----ISIKDTGIGIEKSDLPRIFElgftgyngRIY------TKS 283
Cdd:cd16940    7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADdgavIRVEDNGPGIDEEELEALFE--------RFYrsdgqnYGG 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 681104028 284 TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:cd16940   79 SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
158-314 6.74e-10

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 60.08  E-value: 6.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 158 DYVNMLLAYYR-NNSPTTDYSFSkvRLDDVIRSSVRkyadVFIKNKIKIKVDL--KEAVVISDSKWLEFIISQLISNSLK 234
Cdd:PRK13837 501 LIIDQILAFGRkGERNTKPFDLS--ELVTEIAPLLR----VSLPPGVELDFDQdqEPAVVEGNPAELQQVLMNLCSNAAQ 574
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 235 -YTKSGEITI-----------------ISAENF--ISIKDTGIGIEKSDLPRIFELGFTGYNGriytkSTGIGLNLVKSV 294
Cdd:PRK13837 575 aMDGAGRVDIslsraklrapkvlshgvLPPGRYvlLRVSDTGAGIDEAVLPHIFEPFFTTRAG-----GTGLGLATVHGI 649
                        170       180
                 ....*....|....*....|
gi 681104028 295 ADNLNIDIEVDSNVGEGTTV 314
Cdd:PRK13837 650 VSAHAGYIDVQSTVGRGTRF 669
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
224-314 7.07e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 55.41  E-value: 7.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYTKSG---EITIISAEN----FISIKDTGIGIEKSDLPRIFELgFTGYNGRIYTKSTGIGLNLVKSVAD 296
Cdd:cd16921    4 VLTNLLGNAIKFRRPRrppRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGI-FQRLHSREEYEGTGVGLAIVRKIIE 82
                         90
                 ....*....|....*...
gi 681104028 297 NLNIDIEVDSNVGEGTTV 314
Cdd:cd16921   83 RHGGRIWLESEPGEGTTF 100
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
239-313 7.45e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 55.51  E-value: 7.45e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 681104028 239 GEITIISA----ENFISIKDTGIGIEKSDLPRIFELGFTgynGRIYTKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTT 313
Cdd:cd16943   23 GRITIRTWahvdQVLIEVEDTGSGIDPEILGRIFDPFFT---TKPVGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTR 98
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
225-321 8.10e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 55.67  E-value: 8.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 225 ISQLISNSLKYTK-SGEITI----ISAENFISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKS-TGIGLNLVKSVADNL 298
Cdd:cd16952    5 FSNLVSNAVKYTPpSDTITVrwsqEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVMSRH 84
                         90       100
                 ....*....|....*....|...
gi 681104028 299 NIDIEVDSNVGEGTTVKLKFNNR 321
Cdd:cd16952   85 DARLLIASELGKGSRFTCLFPSS 107
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
224-313 1.47e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 51.90  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYT-----KSGEITI-ISAEN---FISIKDTGIGIEKSDLPRIFELGFTgyngriyTKST---GIGLNLV 291
Cdd:cd16915    4 IVGNLIDNALDALaatgaPNKQVEVfLRDEGddlVIEVRDTGPGIAPELRDKVFERGVS-------TKGQgerGIGLALV 76
                         90       100
                 ....*....|....*....|..
gi 681104028 292 KSVADNLNIDIEVDSNVGEGTT 313
Cdd:cd16915   77 RQSVERLGGSITVESEPGGGTT 98
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
224-318 1.48e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 51.69  E-value: 1.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYTKSGEITIISAEN-----FISIKDTGIGIEKSDLPRIFELGFTGYNGRIYTKSTGIGLNLVKSVADNL 298
Cdd:cd16975    8 ALINIISNACQYAPEGGTVSISIYDeeeylYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKH 87
                         90       100
                 ....*....|....*....|
gi 681104028 299 NIDIEVDSNVGEGTTVKLKF 318
Cdd:cd16975   88 GGSLIIENSQKGGAEVTVKI 107
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
204-317 2.25e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 51.75  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 204 KIKVDLKEAVVIS--DSKWLEFIISQLISNSLKYTKSGEITIIS-----AENFISIKDTGIGIEKSDLPRIFELGFTGYN 276
Cdd:cd16947    2 QVEINIPDRPIYAnaNTEALQRILKNLISNAIKYGSDGKFLGMTlredeKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 681104028 277 GRIYT-KSTGIGLNLVKSVADNLNIDIEVDSNVGEGT--TVKLK 317
Cdd:cd16947   82 SRNSAkQGNGLGLTITKRLAESMGGSIYVNSKPYEKTvfTVTLK 125
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
224-313 2.29e-08

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 55.30  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSL---KYTKSGEITI-ISAEN---FISIKDTGIGIEKSDLPRIFELGFTgyngriyTKST--GIGLNLVKSV 294
Cdd:PRK11086 437 ILGNLIENALeavGGEEGGEISVsLHYRNgwlHCEVSDDGPGIAPDEIDAIFDKGYS-------TKGSnrGVGLYLVKQS 509
                         90
                 ....*....|....*....
gi 681104028 295 ADNLNIDIEVDSNVGEGTT 313
Cdd:PRK11086 510 VENLGGSIAVESEPGVGTQ 528
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
122-313 5.23e-08

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 53.86  E-value: 5.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 122 FYTMWTHQIKTPIAALNLMLEDKNESDLK-------IEVM-----KIEDYVNMLLAYYR-NNSPTTDysfskvrLDDVIR 188
Cdd:PRK11006 207 FFANVSHELRTPLTVLQGYLEMMQDQPLEgalrekaLHTMreqtqRMEGLVKQLLTLSKiEAAPTID-------LNEKVD 279
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 189 -----SSVRKYADVFIKNKIKIKVDLKEAV-VISDSKWLEFIISQLISNSLKYTKSG-EITI----ISAENFISIKDTGI 257
Cdd:PRK11006 280 vpmmlRVLEREAQTLSQGKHTITFEVDNSLkVFGNEDQLRSAISNLVYNAVNHTPEGtHITVrwqrVPQGAEFSVEDNGP 359
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 681104028 258 GIEKSDLPRIFElgftgyngRIY---------TKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTT 313
Cdd:PRK11006 360 GIAPEHIPRLTE--------RFYrvdkarsrqTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTR 416
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
128-308 1.49e-07

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 52.47  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 128 HQIKTPIAALNLMLE-----DKNESDLKiEVM--KIEDYVNM--------LLAYYRNNSPTTDysfsKVRLDdvIRSSVR 192
Cdd:PRK09835 271 HEIRTPITNLITQTEialsqSRSQKELE-DVLysNLEELTRMakmvsdmlFLAQADNNQLIPE----KKMLD--LADEVG 343
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 193 KYADVFI----KNKIKIKVDLKEAVVISDSKWLEFIISQLISNSLKYTKSGEITIIS----AENF-ISIKDTGIGIEKSD 263
Cdd:PRK09835 344 KVFDFFEawaeERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRcqevDHQVqLVVENPGTPIAPEH 423
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 681104028 264 LPRIFElgftgyngRIYT---------KSTGIGLNLVKSVADNLNIDIEVDSNV 308
Cdd:PRK09835 424 LPRLFD--------RFYRvdpsrqrkgEGSGIGLAIVKSIVVAHKGTVAVTSDA 469
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
120-324 6.19e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.89  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  120 NKFYTMWTHQIKTPIAALNLMLEDKNESDLKIEvMKIEdyvNMLLAYYRNNS--------------PTTDYSFSK--VRL 183
Cdd:PRK09959  713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKE-QRVE---AISLAYATGQSllgligeildvdkiESGNYQLQPqwVDI 788
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028  184 DDVIRSSVRKYADVFIKNKIKIKVDLK---EAVVISDSKWLEFIISQLISNSLKYTKSGEITIISA-----ENFISIK-- 253
Cdd:PRK09959  789 PTLVQNTCHSFGAIAASKSIALSCSSTfpdHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSlghidDNHAVIKmt 868
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 681104028  254 --DTGIGIEKSDLPRIFELGFTGYNGRIYTKStGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKFNNRILQ 324
Cdd:PRK09959  869 imDSGSGLSQEEQQQLFKRYSQTSAGRQQTGS-GLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQ 940
PRK15347 PRK15347
two component system sensor kinase;
224-317 6.33e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 50.80  E-value: 6.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYTKSGEI--TIISAEN--FISIKDTGIGIEKSDLPRIFElGFtgYNGRIYTKSTGIGLNLVKSVADNLN 299
Cdd:PRK15347 517 ILVNLLGNAVKFTETGGIrlRVKRHEQqlCFTVEDTGCGIDIQQQQQIFT-PF--YQADTHSQGTGLGLTIASSLAKMMG 593
                         90
                 ....*....|....*...
gi 681104028 300 IDIEVDSNVGEGTTVKLK 317
Cdd:PRK15347 594 GELTLFSTPGVGSCFSLV 611
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
217-311 7.42e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 47.07  E-value: 7.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 217 DSKWLEFIISQLISNSLKYTKSGEITIISAEN-----FISIKDTGIGIEKSDLPRIFELGFT---GYNGRiytKSTGIGL 288
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEAdtegiELLVFDEGSGIPDYALNRVFERFYSlprPHSGQ---KSTGLGL 77
                         90       100
                 ....*....|....*....|...
gi 681104028 289 NLVKSVADNLNIDIEVdSNVGEG 311
Cdd:cd16945   78 AFVQEVAQLHGGRITL-RNRPDG 99
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
122-322 9.20e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 50.29  E-value: 9.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 122 FYTMWTHQIKTPIAAL----NLMLEDKNESDLKIEVMKIEDYVNMLLAYYRNnspTTDYSF-----SKVRLDD------- 185
Cdd:PRK11466 447 FLAAMSHEIRTPLYGIlgtaQLLADNPALNAQRDDLRAITDSGESLLTILND---ILDYSAieaggKNVSVSDepfeprp 523
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 186 VIRSSVRKYADVFIKNKIKIKVDLKEAV---VISDSKWLEFIISQLISNSLKYTKSGEITIISAEN----FISIKDTGIG 258
Cdd:PRK11466 524 LLESTLQLMSGRVKGRPIRLATDIADDLptaLMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDgeqwLVEVEDSGCG 603
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 681104028 259 IEKSDLPRIFElGFTGYNGRiyTKSTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKFNNRI 322
Cdd:PRK11466 604 IDPAKLAEIFQ-PFVQVSGK--RGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRV 664
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
250-318 1.20e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 1.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 681104028 250 ISIKDTGIGIEKSDLPRIFELGFTgyngriyTK----STGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:cd16919   50 LEVSDTGSGMPAEVLRRAFEPFFT-------TKevgkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
224-311 2.31e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 45.52  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYTkSGEITIISAENF----ISIKDTGIGIEKSDLPRIFELGFTGYNGRiYTKSTGIGLNLVKSVADNLN 299
Cdd:cd16950    4 VLSNLVDNALRYG-GGWVEVSSDGEGnrtrIQVLDNGPGIAPEEVDELFQPFYRGDNAR-GTSGTGLGLAIVQRISDAHG 81
                         90
                 ....*....|..
gi 681104028 300 IDIEVDSNVGEG 311
Cdd:cd16950   82 GSLTLANRAGGG 93
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
221-311 2.59e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 49.20  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 221 LEFIISQLISNSLKYTKSGEITI-ISAENF---ISIKDTGIGIEKSDLPRIFELGF-TGYNGRIYTKSTGIGLNLVKSVA 295
Cdd:PRK10841 563 LQQVISNLLSNAIKFTDTGCIVLhVRVDGDylsFRVRDTGVGIPAKEVVRLFDPFFqVGTGVQRNFQGTGLGLAICEKLI 642
                         90
                 ....*....|....*.
gi 681104028 296 DNLNIDIEVDSNVGEG 311
Cdd:PRK10841 643 NMMDGDISVDSEPGMG 658
PRK13557 PRK13557
histidine kinase; Provisional
250-318 3.44e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 48.51  E-value: 3.44e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 681104028 250 ISIKDTGIGIEKSDLPRIFELGFTgyngriyTKS----TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFT-------TKEegkgTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
224-319 6.41e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 44.90  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 224 IISQLISNSLKYT----KSGEITI---ISAENF-ISIKDTGIGIEKSDLPRIFELGFTGyngriytkstGIGLNLVKSVA 295
Cdd:COG2172   38 AVSEAVTNAVRHAyggdPDGPVEVeleLDPDGLeIEVRDEGPGFDPEDLPDPYSTLAEG----------GRGLFLIRRLM 107
                         90       100
                 ....*....|....*....|....
gi 681104028 296 DnlniDIEVDSNVGeGTTVKLKFN 319
Cdd:COG2172  108 D----EVEYESDPG-GTTVRLVKR 126
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
250-316 1.77e-05

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 45.93  E-value: 1.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 681104028 250 ISIKDTGIGIEKSDLPRIFELGFTgyngriyTKS--TGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKL 316
Cdd:PRK10364 383 ISVTDSGKGIAADQLEAIFTPYFT-------TKAegTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
PRK09303 PRK09303
histidine kinase;
194-311 3.35e-05

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 44.94  E-value: 3.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 194 YADVFIKNKIKIKVDLKEAV--VISDSKWLEFIISQLISNSLKYT-KSGEITII-----SAENFISIKDTGIGIEKSDLP 265
Cdd:PRK09303 244 LEKRWLAKSLEIQTDIPSDLpsVYADQERIRQVLLNLLDNAIKYTpEGGTITLSmlhrtTQKVQVSICDTGPGIPEEEQE 323
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 681104028 266 RIFE--------LGFTGYngriytkstGIGLNLVKSVADNLNIDIEVDSNVGEG 311
Cdd:PRK09303 324 RIFEdrvrlprdEGTEGY---------GIGLSVCRRIVRVHYGQIWVDSEPGQG 368
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
203-313 3.65e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 45.23  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 203 IKIKVDLKEAVvISDSKWLEFIISQLISNSLKYTKSGEITI------ISAENF---ISIKDTGIGIEKSDLPRIFElGFT 273
Cdd:PRK11107 392 LNIDPDVPDNV-IGDPLRLQQIITNLVGNAIKFTESGNIDIlvelraLSNTKVqleVQIRDTGIGISERQQSQLFQ-AFR 469
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 681104028 274 GYNGRIYTKSTGIGLNLV--KSVADNLNIDIEVDSNVGEGTT 313
Cdd:PRK11107 470 QADASISRRHGGTGLGLVitQKLVNEMGGDISFHSQPNRGST 511
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
250-313 7.67e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 41.23  E-value: 7.67e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 681104028 250 ISIKDTGIGIEKSDLPRIFELGFTgyngriyTKST--GIGLNLVKSVADNLNIDIEVDSNVGEGTT 313
Cdd:cd16920   40 ISVKDTGPGIAEEVAGQLFDPFYT-------TKSEglGMGLSICRSIIEAHGGRLSVESPAGGGAT 98
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
127-269 1.11e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 43.47  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 127 THQIKTPIAALNLMLEDKNE----------SDLKIEVMKIEDYVNML----------LAYYRnnspttdysfSKVRLDDV 186
Cdd:PRK10549 248 SHELRTPLAVLRGELEAIQDgvrkftpesvASLQAEVGTLTKLVDDLhqlslsdegaLAYRK----------TPVDLVPL 317
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 187 IRSSVRKYADVFIKNKIKIKVDLKE-AVVISDSKWLEFIISQLISNSLKYTKSGEITIISAE-----NFISIKDTGIGIE 260
Cdd:PRK10549 318 LEVAGGAFRERFASRGLTLQLSLPDsATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEqrdktLRLTFADSAPGVS 397

                 ....*....
gi 681104028 261 KSDLPRIFE 269
Cdd:PRK10549 398 DEQLQKLFE 406
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
217-318 3.41e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 39.37  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 217 DSKWLEFIISQLISNSLKYTKSGEITIISAENF-----ISIKDTGIGIEKSDLPRIFELGFTGYNGRIY-TKSTGIGLNL 290
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTpqevrLDVEDSAPGVSDDQLARLFERFYRVESSRNRaSGGSGLGLAI 80
                         90       100
                 ....*....|....*....|....*...
gi 681104028 291 VKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:cd16946   81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
155-318 8.15e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.77  E-value: 8.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 155 KIEDYVNMLLAYYRNNSPTTDysfSKVRLDDVIRSsVRKYadVFIK-----NKIKIKVDLKEAvvISDSKWLEFIISQLI 229
Cdd:COG2972  274 EAEEMLEALSKLLRYSLSKGD---ELVTLEEELEL-IKSY--LEIQklrfgDRLEVEIEIDEE--LLDLLIPKLILQPLV 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 230 SNSLKY-----TKSGEITI-ISAEN---FISIKDTGIGIEKSDLPRIFELGFTGYNGRiytkstGIGLNLVKS---VADN 297
Cdd:COG2972  346 ENAIEHgiepkEGGGTIRIsIRKEGdrlVITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLRNVRErlkLYYG 419
                        170       180
                 ....*....|....*....|.
gi 681104028 298 LNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG2972  420 EEYGLEIESEPGEGTTVTIRI 440
PRK13560 PRK13560
hypothetical protein; Provisional
173-318 8.24e-04

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 41.20  E-value: 8.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 173 TTDYSFskVRLDDVIRSSVRKYADVFI--KNKIKIKVDLKEAVV-ISDSKWLEFIISQLISNSLKY----TKSGEITIIS 245
Cdd:PRK13560 663 SEDLAD--IDFLDYIESLTAHLKNSFAidFGRIDCKIDADDGCLdIDKAIPCGLIISELLSNALKHafpdGAAGNIKVEI 740
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 681104028 246 AENF-----ISIKDTGIGieksdLPRIFElgftgyngriYTKSTGIGLNLVKSVADNLNIDIEVDSNvgEGTTVKLKF 318
Cdd:PRK13560 741 REQGdgmvnLCVADDGIG-----LPAGFD----------FRAAETLGLQLVCALVKQLDGEIALDSR--GGARFNIRF 801
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
217-292 2.05e-03

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 37.47  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 217 DSKWLEFIISQLISNSLKYTKSGEITIISAENF------ISIKDTGIGIEKSDLPRIFE-LGFTGYNGRIYTKSTGIGLN 289
Cdd:cd16925    1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrlnrflLTVSDSGPGIPPNLREEIFErFRQGDGSSTRAHGGTGLGLS 80

                 ...
gi 681104028 290 LVK 292
Cdd:cd16925   81 IVK 83
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
221-318 2.36e-03

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 37.35  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 221 LEFIISQLISNSLKYTKSGEITIIS------AENFISIKDTGIGIekSDLPRIFELGFTGyngriyTKSTGIGLNLVKSV 294
Cdd:cd16934   26 IATAVTELARNLLKHAGGGQVLLEVvaeggrVALEILAVDQGPGI--ADVDEALRDGFST------GGGLGLGLGGVRRL 97
                         90       100
                 ....*....|....*....|....
gi 681104028 295 ADNLNIdievDSNVGEGTTVKLKF 318
Cdd:cd16934   98 ADEFDL----HSAPGRGTVVVARK 117
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
124-319 3.61e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.90  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 124 TMWT--HQIKTPIAALN-------LMLEDKNESDLKIEVMKIEDYV---NMLLAYYRNNSPTTDYSFSKVRLDDVIRSSV 191
Cdd:COG4192  436 TMTSlaHELNQPLNAMSmylfsakKALEQENYAQLPTSLDKIEGLIermDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAW 515
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 192 RKYADVFIKNKIKIKVDlKEAVVISDSKWLEFIISQLISNSLK-YTKSGEITIISAEN----FISIKDTGIGIEksDLPR 266
Cdd:COG4192  516 ELVESRAKPQQITLHIP-DDLMVQGDQVLLEQVLVNLLVNALDaVATQPQISVDLLSNaenlRVAISDNGNGWP--LVDK 592
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 681104028 267 IFELGFTgyngriyTKST--GIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKFN 319
Cdd:COG4192  593 LFTPFTT-------TKEVglGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
231-318 4.58e-03

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 38.68  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 231 NSLKYTKSGEITII-----SAENFISIKDTGIGIEKSDLPrifelgfTGYngriYtkstgiGLNLVKSVADNLNIDIEVD 305
Cdd:PRK10935 482 NAIKHANASEIAVScvtnpDGEHTVSIRDDGIGIGELKEP-------EGH----Y------GLNIMQERAERLGGTLTIS 544
                         90
                 ....*....|...
gi 681104028 306 SNVGEGTTVKLKF 318
Cdd:PRK10935 545 QPPGGGTTVSLTF 557
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
183-318 5.79e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 37.68  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 183 LDDV-IRSSVRKYADVFIK-NKIKIKVDLK-EAVVISDSKWLEF--IISQLISNSLKYTKSGEITI-ISAEN---FISIK 253
Cdd:COG4585  120 LDDLgLAAALEELAERLLRaAGIRVELDVDgDPDRLPPEVELALyrIVQEALTNALKHAGATRVTVtLEVDDgelTLTVR 199
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 681104028 254 DTGIGIEKSDLPRifelgftgyngriytksTGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLKF 318
Cdd:COG4585  200 DDGVGFDPEAAPG-----------------GGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
239-317 9.72e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 36.41  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104028 239 GEITIiSAEN-----FISIKDTGIGIEKSDLPR------------------------IFELGF------TGYNGRiytks 283
Cdd:cd16916   70 GTITL-RAEHqgnqvVIEVSDDGRGIDREKIREkaierglitadeaatlsddevlnlIFAPGFstaeqvTDVSGR----- 143
                         90       100       110
                 ....*....|....*....|....*....|....
gi 681104028 284 tGIGLNLVKSVADNLNIDIEVDSNVGEGTTVKLK 317
Cdd:cd16916  144 -GVGMDVVKRSIESLGGTIEVESEPGQGTTFTIR 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH