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Conserved domains on  [gi|678194766|gb|AIM49324|]
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beta-tubulin, partial [Psathyrella gordonii]

Protein Classification

FtsZ/tubulin family protein( domain architecture ID 3)

FtsZ/tubulin family protein may be involved in polymer formation, similar to the cell-division GTPase FtsZ or the tubulin-like filament-forming GTPase TubZ

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin_FtsZ_Cetz-like super family cl10017
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 1-117 2.81e-90

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


The actual alignment was detected with superfamily member cd02187:

Pssm-ID: 471962 [Multi-domain]  Cd Length: 425  Bit Score: 267.12  E-value: 2.81e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02187  140 GGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFCIDNEALYNICQRTLKLTQP 219

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd02187  220 TYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNL 256
 
Name Accession Description Interval E-value
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-117 2.81e-90

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 267.12  E-value: 2.81e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02187  140 GGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFCIDNEALYNICQRTLKLTQP 219

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd02187  220 TYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNL 256
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 1-117 8.24e-90

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 266.64  E-value: 8.24e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:PTZ00010 141 GGTGSGMGTLLISKLREEYPDRIMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADESMCIDNEALYDICFRTLKLTTP 220

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PTZ00010 221 TYGDLNHLVSAVMSGVTCCLRFPGQLNSDLRKLAVNL 257
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
 1-104 3.86e-38

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 126.83  E-value: 3.86e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766     1 GGTGAGMGTLLISKIREeYPDRMMctySVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLsTP 80
Cdd:smart00864  94 GGTGTGAAPVIAEIAKE-YGILTV---AVVTKPFSFEGVVRPYNAELGLEELREHVDSLIVIDNDALLDICGRKLPL-RP 168

                           90       100
                   ....*....|....*....|....
gi 678194766    81 TYGDLNHLVSIVMSGITTCLRFPG 104
Cdd:smart00864 169 AFKDANDLLAQAVSGITDLIRFPG 192
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-71 1.15e-24

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 92.28  E-value: 1.15e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 678194766    1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSpKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDIC 71
Cdd:pfam00091 120 GGTGSGAAPVIAEILKELYPGALTVAVVTFPF-GFSEGVVRPYNAILGLKELIEHSDSVIVIDNDALYDIC 189
 
Name Accession Description Interval E-value
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-117 2.81e-90

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 267.12  E-value: 2.81e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02187  140 GGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFCIDNEALYNICQRTLKLTQP 219

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd02187  220 TYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNL 256
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 1-117 8.24e-90

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 266.64  E-value: 8.24e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:PTZ00010 141 GGTGSGMGTLLISKLREEYPDRIMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADESMCIDNEALYDICFRTLKLTTP 220

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PTZ00010 221 TYGDLNHLVSAVMSGVTCCLRFPGQLNSDLRKLAVNL 257
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-117 2.28e-88

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 262.84  E-value: 2.28e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:PLN00220 141 GGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTP 220

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PLN00220 221 SFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNL 257
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 1-117 3.62e-47

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 154.10  E-value: 3.62e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSdTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd00286  102 GGTGSGLGPLLAERLKDEYPNRLVVTFSILPGPDEG-VIVYPYNAALTLKTLTEHADCLLLVDNEALYDICPRPLHIDAP 180

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd00286  181 AYDHINELVAQRLGSLTEALRFEGSLNVDLRELAENL 217
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 1-117 7.75e-45

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 149.27  E-value: 7.75e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFR---TLKL 77
Cdd:cd06059  102 GGTGSGLGSYLLELLEDEYPKVYRFTFSVFPSPDDDNVITSPYNSVLALNHLTEHADCVLPIDNEALYDICNRqpaTLDI 181

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 678194766  78 STPTYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd06059  182 DFPPFDDMNNLVAQLLSSLTSSLRFEGSLNVDLNEITTNL 221
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-116 1.71e-44

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 149.23  E-value: 1.71e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02186  142 GGTGSGLTSLLLERLSVDYGKKSKLEFSIYPSPQVSTSVVEPYNSVLTTHSLLEHSDCSILLDNEALYDICRRQLDIERP 221

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVN 116
Cdd:cd02186  222 TYTNLNRLIAQVVSSLTASLRFDGALNVDLNEFQTN 257
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 1-117 1.34e-41

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 142.15  E-value: 1.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:PTZ00335 143 GGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRNLDIERP 222

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PTZ00335 223 TYTNLNRLIAQVISSLTASLRFDGALNVDLTEFQTNL 259
PLN00221 PLN00221
tubulin alpha chain; Provisional
 1-117 3.55e-39

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 135.71  E-value: 3.55e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:PLN00221 143 GGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERP 222

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 678194766  81 TYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PLN00221 223 TYTNLNRLISQVISSLTASLRFDGALNVDITEFQTNL 259
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
 1-104 3.86e-38

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 126.83  E-value: 3.86e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766     1 GGTGAGMGTLLISKIREeYPDRMMctySVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLsTP 80
Cdd:smart00864  94 GGTGTGAAPVIAEIAKE-YGILTV---AVVTKPFSFEGVVRPYNAELGLEELREHVDSLIVIDNDALLDICGRKLPL-RP 168

                           90       100
                   ....*....|....*....|....
gi 678194766    81 TYGDLNHLVSIVMSGITTCLRFPG 104
Cdd:smart00864 169 AFKDANDLLAQAVSGITDLIRFPG 192
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
 1-113 1.59e-37

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 130.74  E-value: 1.59e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSPK-VSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLST 79
Cdd:cd02188  141 GGTGSGMGSYLLERLSDRYPKKLIQTYSVFPNQEeSSDVVVQPYNSILTLKRLTLNADCVVVLDNTALNRIATDRLKIDN 220

                         90       100       110
                 ....*....|....*....|....*....|....
gi 678194766  80 PTYGDLNHLVSIVMSGITTCLRFPGQLNSDLRKL 113
Cdd:cd02188  221 PSFSQINSLISTVMSASTSTLRFPGYMNNDLVSL 254
PLN00222 PLN00222
tubulin gamma chain; Provisional
 1-110 1.23e-29

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 110.32  E-value: 1.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPS-PKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLST 79
Cdd:PLN00222 143 GGTGSGMGSYLLEALNDRYSKKLVQTYSVFPNqMETSDVVVQPYNSLLTLKRLTLNADCVVVLDNTALNRIAVDRLHLEN 222

                         90       100       110
                 ....*....|....*....|....*....|.
gi 678194766  80 PTYGDLNHLVSIVMSGITTCLRFPGQLNSDL 110
Cdd:PLN00222 223 PTFAQTNSLVSTVMSASTTTLRYPGYMNNDL 253
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-71 1.15e-24

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 92.28  E-value: 1.15e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 678194766    1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSpKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDIC 71
Cdd:pfam00091 120 GGTGSGAAPVIAEILKELYPGALTVAVVTFPF-GFSEGVVRPYNAILGLKELIEHSDSVIVIDNDALYDIC 189
PTZ00387 PTZ00387
epsilon tubulin; Provisional
 1-117 1.22e-23

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 93.64  E-value: 1.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSpKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLST- 79
Cdd:PTZ00387 142 GGTGSGLGTRILGMLEDEFPHVFRFCPVVFPS-AVDDVITSPYNSFFALRELIEHADCVLPLDNDALANIADSALSRKKk 220

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 678194766  80 --------------------PT------YGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:PTZ00387 221 klakgnikrgpqphkysvakPTetkklpYDKMNNIVAQLLSNLTSSMRFEGSLNVDINEITTNL 284
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
 1-117 3.81e-22

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 89.61  E-value: 3.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSpKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02190  147 GGTGSGLGSYILELLEDEFPDVYRFVTSVFPS-GDDDVITSPYNSVLALRELTEHADCVLPVENQALMDIVNKIKSSKDK 225

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 678194766  81 T----------------------YGDLNHLVSIVMSGITTCLRFPGQLNSDLRKLAVNM 117
Cdd:cd02190  226 GktgvlaainssgggqkkgkkkpFDDMNNIVANLLLNLTSSMRFEGSLNVDLNEITTNL 284
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-90 4.75e-19

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 80.77  E-value: 4.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678194766   1 GGTGAGMGTLLISKIREEYPDRMMCTYSVVPSpKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLSTP 80
Cdd:cd02189  135 GGTGSGLGSRVTELLRDEYPKAYLLNTVVWPY-SSGEVPVQNYNTLLTLSHLQESSDGILLFENDDLHKICSKLLGLKNP 213

                         90
                 ....*....|.
gi 678194766  81 -TYGDLNHLVS 90
Cdd:cd02189  214 vSFSDINRVIA 224
CetZ_tubulin-like cd02202
Cell-structure-related euryarchaeota tubulin/FtsZ homologs; CetZ proteins comprise a distinct ...
 1-69 1.21e-03

Cell-structure-related euryarchaeota tubulin/FtsZ homologs; CetZ proteins comprise a distinct tubulin/FtsZ family. The crystal structures of CetZ contain the FtsZ/tubulin superfamily fold and its family members have mosaic of tubulin-like and FtsZ-like amino acid residues. However, a recent study found that CetZ proteins (formerly annotated FtsZ type 2) are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276962 [Multi-domain]  Cd Length: 357  Bit Score: 36.84  E-value: 1.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 678194766   1 GGTGAGMGTLLISKIREEYPdrmMCTYSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYD 69
Cdd:cd02202  109 GGTGSGAAPVLAEELKERYD---KPVYALGVLPAAEEGGRYALNAARSLRSLVELADAVILFDNDAWRR 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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