NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|677481264|gb|KFQ70669|]
View 

Coiled-coil and C2 domain-containing protein 2A, partial [Phaethon lepturus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 51-300 1.61e-110

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


:

Pssm-ID: 465443  Cd Length: 255  Bit Score: 350.43  E-value: 1.61e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264    51 LKSIRESKTEVGRDKVSDNDKFKDMQEDE-SHLPSKIKFRDSVKKLKQKSTFQNDFPSTEEAYNFFTFNFDPEPES--IK 127
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEpfEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   128 PGARKKNELNEEEETGEEHVETHEDEQEEDETDE-DIRLV-KDDDLFIIGQTAEDFLVMKPAVCESYSEQLKKEKEFLFT 205
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEQEAEKMDeEELLVgDDEEDFLIDQTADDFLEVRPAEYESYHERLKKEKEILFV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   206 PSTLAVPISEKMPGNMQPRYLEDEGLYTGERPFVSQSNQNILENRILRQEQGKEWFGDDGKILALPNPIKQSSTRPPIFS 285
Cdd:pfam17661  161 PSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPIFS 240

                          250
                   ....*....|....*
gi 677481264   286 LEEGIAPELETVYRK 300
Cdd:pfam17661  241 LEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 561-735 1.98e-82

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


:

Pssm-ID: 464780  Cd Length: 174  Bit Score: 267.73  E-value: 1.98e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   561 PGEPALIPELVLSGNITPTELCPRAEVLRREDVKKRSTFIKVLFNSKEVSRTVTRPISSDFRVHFGQIFNLQIFNWPESL 640
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   641 KLQIYETTGMSSTTLLAEVFIPVPEPTILTGSAP-MEEIEFSSNQRVMLDHEGVGSGVsfSFEADGSKKMTLMTSGKVSN 719
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGV--PLEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 677481264   720 SVSWAVGEKGIPLIPP 735
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2 super family cl14603
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
 1016-1056 2.66e-04

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


The actual alignment was detected with superfamily member cd04018:

Pssm-ID: 472691 [Multi-domain]  Cd Length: 151  Bit Score: 43.01  E-value: 2.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 677481264 1016 NQVLVRPFVEVSFQ-RTVCRTTTAEGPNPNWNEELELPFRAP 1056
Cdd:cd04018    31 KKELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
 
Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 51-300 1.61e-110

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 350.43  E-value: 1.61e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264    51 LKSIRESKTEVGRDKVSDNDKFKDMQEDE-SHLPSKIKFRDSVKKLKQKSTFQNDFPSTEEAYNFFTFNFDPEPES--IK 127
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEpfEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   128 PGARKKNELNEEEETGEEHVETHEDEQEEDETDE-DIRLV-KDDDLFIIGQTAEDFLVMKPAVCESYSEQLKKEKEFLFT 205
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEQEAEKMDeEELLVgDDEEDFLIDQTADDFLEVRPAEYESYHERLKKEKEILFV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   206 PSTLAVPISEKMPGNMQPRYLEDEGLYTGERPFVSQSNQNILENRILRQEQGKEWFGDDGKILALPNPIKQSSTRPPIFS 285
Cdd:pfam17661  161 PSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPIFS 240

                          250
                   ....*....|....*
gi 677481264   286 LEEGIAPELETVYRK 300
Cdd:pfam17661  241 LEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 561-735 1.98e-82

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 267.73  E-value: 1.98e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   561 PGEPALIPELVLSGNITPTELCPRAEVLRREDVKKRSTFIKVLFNSKEVSRTVTRPISSDFRVHFGQIFNLQIFNWPESL 640
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   641 KLQIYETTGMSSTTLLAEVFIPVPEPTILTGSAP-MEEIEFSSNQRVMLDHEGVGSGVsfSFEADGSKKMTLMTSGKVSN 719
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGV--PLEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 677481264   720 SVSWAVGEKGIPLIPP 735
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2C_Ferlin cd04018
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ...
 1016-1056 2.66e-04

C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 175985 [Multi-domain]  Cd Length: 151  Bit Score: 43.01  E-value: 2.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 677481264 1016 NQVLVRPFVEVSFQ-RTVCRTTTAEGPNPNWNEELELPFRAP 1056
Cdd:cd04018    31 KKELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
C2 pfam00168
C2 domain;
1022-1126 2.83e-03

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 38.84  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264  1022 PFVEVSF--QRTVCRTTTAE-GPNPNWNEELELPFRAPNGdysthslqsvkDEVFINVFDevlhdaveDDRERGSEIhth 1098
Cdd:pfam00168   24 PYVKVYLldGKQKKKTKVVKnTLNPVWNETFTFSVPDPEN-----------AVLEIEVYD--------YDRFGRDDF--- 81

                           90       100
                   ....*....|....*....|....*...
gi 677481264  1099 verhwLGCVKIPFTTIYFQARIDGTFKV 1126
Cdd:pfam00168   82 -----IGEVRIPLSELDSGEGLDGWYPL 104
 
Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 51-300 1.61e-110

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 350.43  E-value: 1.61e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264    51 LKSIRESKTEVGRDKVSDNDKFKDMQEDE-SHLPSKIKFRDSVKKLKQKSTFQNDFPSTEEAYNFFTFNFDPEPES--IK 127
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEpfEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   128 PGARKKNELNEEEETGEEHVETHEDEQEEDETDE-DIRLV-KDDDLFIIGQTAEDFLVMKPAVCESYSEQLKKEKEFLFT 205
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEQEAEKMDeEELLVgDDEEDFLIDQTADDFLEVRPAEYESYHERLKKEKEILFV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   206 PSTLAVPISEKMPGNMQPRYLEDEGLYTGERPFVSQSNQNILENRILRQEQGKEWFGDDGKILALPNPIKQSSTRPPIFS 285
Cdd:pfam17661  161 PSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPIFS 240

                          250
                   ....*....|....*
gi 677481264   286 LEEGIAPELETVYRK 300
Cdd:pfam17661  241 LEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 561-735 1.98e-82

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 267.73  E-value: 1.98e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   561 PGEPALIPELVLSGNITPTELCPRAEVLRREDVKKRSTFIKVLFNSKEVSRTVTRPISSDFRVHFGQIFNLQIFNWPESL 640
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264   641 KLQIYETTGMSSTTLLAEVFIPVPEPTILTGSAP-MEEIEFSSNQRVMLDHEGVGSGVsfSFEADGSKKMTLMTSGKVSN 719
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGV--PLEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 677481264   720 SVSWAVGEKGIPLIPP 735
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2C_Ferlin cd04018
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ...
 1016-1056 2.66e-04

C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 175985 [Multi-domain]  Cd Length: 151  Bit Score: 43.01  E-value: 2.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 677481264 1016 NQVLVRPFVEVSFQ-RTVCRTTTAEGPNPNWNEELELPFRAP 1056
Cdd:cd04018    31 KKELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
C2 pfam00168
C2 domain;
1022-1126 2.83e-03

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 38.84  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 677481264  1022 PFVEVSF--QRTVCRTTTAE-GPNPNWNEELELPFRAPNGdysthslqsvkDEVFINVFDevlhdaveDDRERGSEIhth 1098
Cdd:pfam00168   24 PYVKVYLldGKQKKKTKVVKnTLNPVWNETFTFSVPDPEN-----------AVLEIEVYD--------YDRFGRDDF--- 81

                           90       100
                   ....*....|....*....|....*...
gi 677481264  1099 verhwLGCVKIPFTTIYFQARIDGTFKV 1126
Cdd:pfam00168   82 -----IGEVRIPLSELDSGEGLDGWYPL 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH