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Conserved domains on  [gi|676276012|gb|KFO30337|]
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DENN domain-containing protein 2C [Fukomys damarensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCAS2 pfam05700
Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic ...
 956-1158 4.38e-96

Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins. BCAS2 is a putative spliceosome associated protein.


:

Pssm-ID: 428593 [Multi-domain]  Cd Length: 204  Bit Score: 304.51  E-value: 4.38e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   956 VVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELP 1035
Cdd:pfam05700    1 EVHDSLPYIDDEYEDPGLREAADALIEEELRRSRPTPNYLPDLPPPPEPAFFSPLLAAELERVEAGQPLTALDLSRYELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012  1036 APSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNM 1115
Cdd:pfam05700   81 APPSGKRNDLEAWKEALDNAYAQLEHQRIRIENLELLQKYGANAWRLHNYQLEAILRRLEKELAETKEAIEEVNRQRKNA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 676276012  1116 QLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQQ 1158
Cdd:pfam05700  161 QTAAGGELRSLEEKWKELVSKNLEIEAACEALEAEILELKRQA 203
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 602-785 2.05e-76

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 249.80  E-value: 2.05e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   602 LPEVYCMVSRLGCFNLFSKILDEVEKRREMS--PALVCPFMRS-VMEAPFPAPGRTITVKsylPGAGDGSIELCRPLDSR 678
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISplPNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   679 L--EHVDFECLFKCLSVCHLVRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTP 756
Cdd:pfam02141   79 LplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTP 158

                          170       180
                   ....*....|....*....|....*....
gi 676276012   757 FLIGILSCSLPqLQDLPIEEVLIVDLCAD 785
Cdd:pfam02141  159 FIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 502-591 4.31e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.32  E-value: 4.31e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    502 EQQLFELFVVVSLQK--QPSGISYTPQVIQQFPSKDDhgykqskDTEERLKVIPKFCFPDSEDWQPTSE-LKSETFSFVL 578
Cdd:smart00800    1 PSRLFDYFVVVGLDSdtGPLGRSYKPEILQRYPEKDF-------EDFPLPDSIPLFCFPEGLDFVTQTSsKDPQFFSFVL 73

                            90
                    ....*....|...
gi 676276012    579 TGEDGSRWFGYCK 591
Cdd:smart00800   74 TDIDGSRRYGFCL 86
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 831-897 5.81e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 79.26  E-value: 5.81e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    831 NSLVSEAFVRFFVELVGHYS---LNVTVTERGERVFQREPFRKSHTSRSiRHFLDLFMETQMFAGFIQDR 897
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRnflRELRKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
BCAS2 pfam05700
Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic ...
 956-1158 4.38e-96

Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins. BCAS2 is a putative spliceosome associated protein.


Pssm-ID: 428593 [Multi-domain]  Cd Length: 204  Bit Score: 304.51  E-value: 4.38e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   956 VVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELP 1035
Cdd:pfam05700    1 EVHDSLPYIDDEYEDPGLREAADALIEEELRRSRPTPNYLPDLPPPPEPAFFSPLLAAELERVEAGQPLTALDLSRYELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012  1036 APSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNM 1115
Cdd:pfam05700   81 APPSGKRNDLEAWKEALDNAYAQLEHQRIRIENLELLQKYGANAWRLHNYQLEAILRRLEKELAETKEAIEEVNRQRKNA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 676276012  1116 QLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQQ 1158
Cdd:pfam05700  161 QTAAGGELRSLEEKWKELVSKNLEIEAACEALEAEILELKRQA 203
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 602-785 2.05e-76

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 249.80  E-value: 2.05e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   602 LPEVYCMVSRLGCFNLFSKILDEVEKRREMS--PALVCPFMRS-VMEAPFPAPGRTITVKsylPGAGDGSIELCRPLDSR 678
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISplPNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   679 L--EHVDFECLFKCLSVCHLVRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTP 756
Cdd:pfam02141   79 LplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTP 158

                          170       180
                   ....*....|....*....|....*....
gi 676276012   757 FLIGILSCSLPqLQDLPIEEVLIVDLCAD 785
Cdd:pfam02141  159 FIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 602-785 7.49e-72

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 237.09  E-value: 7.49e-72
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    602 LPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVCPFMRSVMEAPFPAPGRTITVKSYLPGagdGSIELCRPLDSRLEH 681
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    682 VDFEC--LFKCLSVCHLVRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLI 759
Cdd:smart00799   78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 676276012    760 GILSCSLPQLQDLPIEEVLIVDLCAD 785
Cdd:smart00799  158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 502-591 4.31e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.32  E-value: 4.31e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    502 EQQLFELFVVVSLQK--QPSGISYTPQVIQQFPSKDDhgykqskDTEERLKVIPKFCFPDSEDWQPTSE-LKSETFSFVL 578
Cdd:smart00800    1 PSRLFDYFVVVGLDSdtGPLGRSYKPEILQRYPEKDF-------EDFPLPDSIPLFCFPEGLDFVTQTSsKDPQFFSFVL 73

                            90
                    ....*....|...
gi 676276012    579 TGEDGSRWFGYCK 591
Cdd:smart00800   74 TDIDGSRRYGFCL 86
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 831-897 5.81e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 79.26  E-value: 5.81e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    831 NSLVSEAFVRFFVELVGHYS---LNVTVTERGERVFQREPFRKSHTSRSiRHFLDLFMETQMFAGFIQDR 897
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRnflRELRKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 525-590 2.09e-15

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 71.49  E-value: 2.09e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 676276012   525 PQVIQQFPSKDDHGYKQSKDteerlkvIPKFCFPDseDWQPTSELKSETFSFVLTGEDGSRWFGYC 590
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDG-------IPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGAC 57
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 863-911 1.31e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 60.29  E-value: 1.31e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 676276012   863 FQREPFRKSHTSRSiRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEVR 911
Cdd:pfam03455    1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Name Accession Description Interval E-value
BCAS2 pfam05700
Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic ...
 956-1158 4.38e-96

Breast carcinoma amplified sequence 2 (BCAS2); This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins. BCAS2 is a putative spliceosome associated protein.


Pssm-ID: 428593 [Multi-domain]  Cd Length: 204  Bit Score: 304.51  E-value: 4.38e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   956 VVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELP 1035
Cdd:pfam05700    1 EVHDSLPYIDDEYEDPGLREAADALIEEELRRSRPTPNYLPDLPPPPEPAFFSPLLAAELERVEAGQPLTALDLSRYELP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012  1036 APSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNM 1115
Cdd:pfam05700   81 APPSGKRNDLEAWKEALDNAYAQLEHQRIRIENLELLQKYGANAWRLHNYQLEAILRRLEKELAETKEAIEEVNRQRKNA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 676276012  1116 QLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQQ 1158
Cdd:pfam05700  161 QTAAGGELRSLEEKWKELVSKNLEIEAACEALEAEILELKRQA 203
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 602-785 2.05e-76

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 249.80  E-value: 2.05e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   602 LPEVYCMVSRLGCFNLFSKILDEVEKRREMS--PALVCPFMRS-VMEAPFPAPGRTITVKsylPGAGDGSIELCRPLDSR 678
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISplPNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012   679 L--EHVDFECLFKCLSVCHLVRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTP 756
Cdd:pfam02141   79 LplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTP 158

                          170       180
                   ....*....|....*....|....*....
gi 676276012   757 FLIGILSCSLPqLQDLPIEEVLIVDLCAD 785
Cdd:pfam02141  159 FIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 602-785 7.49e-72

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 237.09  E-value: 7.49e-72
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    602 LPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVCPFMRSVMEAPFPAPGRTITVKSYLPGagdGSIELCRPLDSRLEH 681
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    682 VDFEC--LFKCLSVCHLVRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLI 759
Cdd:smart00799   78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 676276012    760 GILSCSLPQLQDLPIEEVLIVDLCAD 785
Cdd:smart00799  158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 502-591 4.31e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.32  E-value: 4.31e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    502 EQQLFELFVVVSLQK--QPSGISYTPQVIQQFPSKDDhgykqskDTEERLKVIPKFCFPDSEDWQPTSE-LKSETFSFVL 578
Cdd:smart00800    1 PSRLFDYFVVVGLDSdtGPLGRSYKPEILQRYPEKDF-------EDFPLPDSIPLFCFPEGLDFVTQTSsKDPQFFSFVL 73

                            90
                    ....*....|...
gi 676276012    579 TGEDGSRWFGYCK 591
Cdd:smart00800   74 TDIDGSRRYGFCL 86
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 831-897 5.81e-18

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 79.26  E-value: 5.81e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 676276012    831 NSLVSEAFVRFFVELVGHYS---LNVTVTERGERVFQREPFRKSHTSRSiRHFLDLFMETQMFAGFIQDR 897
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRnflRELRKEPGPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 525-590 2.09e-15

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 71.49  E-value: 2.09e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 676276012   525 PQVIQQFPSKDDHGYKQSKDteerlkvIPKFCFPDseDWQPTSELKSETFSFVLTGEDGSRWFGYC 590
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDG-------IPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGAC 57
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 863-911 1.31e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 60.29  E-value: 1.31e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 676276012   863 FQREPFRKSHTSRSiRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEVR 911
Cdd:pfam03455    1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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